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WO2008087367A3 - Substituted (phenylthiazolyl)-phenyl-propan-1-one and (phenyloxazodyl)-phenyl-propan-1-one derivatives, preparations and uses of same - Google Patents

Substituted (phenylthiazolyl)-phenyl-propan-1-one and (phenyloxazodyl)-phenyl-propan-1-one derivatives, preparations and uses of same Download PDF

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Publication number
WO2008087367A3
WO2008087367A3 PCT/FR2007/052635 FR2007052635W WO2008087367A3 WO 2008087367 A3 WO2008087367 A3 WO 2008087367A3 FR 2007052635 W FR2007052635 W FR 2007052635W WO 2008087367 A3 WO2008087367 A3 WO 2008087367A3
Authority
WO
WIPO (PCT)
Prior art keywords
propan
phenyl
phenylthiazolyl
substituted
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2007/052635
Other languages
French (fr)
Other versions
WO2008087367A2 (en
Inventor
Jean-Francois Delhomel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genfit SA
Original Assignee
Genfit SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit SA filed Critical Genfit SA
Publication of WO2008087367A2 publication Critical patent/WO2008087367A2/en
Publication of WO2008087367A3 publication Critical patent/WO2008087367A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to substituted (phenylthiazolyl)-phenyl-propan-1-one and phenyloxazolyl)-phenyl-propan-1-one derivative compounds, pharmaceutical compositions comprising same, and therapeutic uses thereof, especially in the fields of human and animal health.
PCT/FR2007/052635 2006-12-29 2007-12-28 Substituted (phenylthiazolyl)-phenyl-propan-1-one and (phenyloxazodyl)-phenyl-propan-1-one derivatives, preparations and uses of same Ceased WO2008087367A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0656065 2006-12-29
FR0656065A FR2910893A1 (en) 2006-12-29 2006-12-29 New Phenylthiazolyl/phenyloxazolyl derivatives are peroxisome proliferator-activated receptor agonist useful to treat e.g. diabetic, dyslipidemia, cardiovascular disease, hypertension, inflammatory diseases and cerebral ischaemia

Publications (2)

Publication Number Publication Date
WO2008087367A2 WO2008087367A2 (en) 2008-07-24
WO2008087367A3 true WO2008087367A3 (en) 2008-11-06

Family

ID=38257586

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2007/052635 Ceased WO2008087367A2 (en) 2006-12-29 2007-12-28 Substituted (phenylthiazolyl)-phenyl-propan-1-one and (phenyloxazodyl)-phenyl-propan-1-one derivatives, preparations and uses of same

Country Status (2)

Country Link
FR (1) FR2910893A1 (en)
WO (1) WO2008087367A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009002514A1 (en) * 2009-04-21 2010-10-28 Evonik Degussa Gmbh Process for the preparation of substituted 1,4-quinone methides
CA2770494A1 (en) * 2009-08-14 2011-02-17 Ronald Barbaras Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013186089A2 (en) 2012-06-14 2013-12-19 Basf Se Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests
CN103588767B (en) * 2013-11-20 2016-01-20 苏州明锐医药科技有限公司 The preparation method of Da Lafeini
US12053445B2 (en) 2016-03-31 2024-08-06 Genfit Methods of treatment of cholestatic diseases
CN108658908B (en) 2017-07-31 2019-05-10 广州必贝特医药技术有限公司 1,3- bis- replaces ketene compounds and its application
WO2021169769A1 (en) * 2020-02-28 2021-09-02 四川科伦博泰生物医药股份有限公司 Aromatic compound and pharmaceutical composition and use thereof
US20240216313A1 (en) 2021-05-11 2024-07-04 Genfit Elafibranor derivatives agonists of ppar for use in the treatment of sepsis
AU2022274304A1 (en) 2021-05-11 2023-10-26 Genfit Ppar-agonists for use in the treatment of liver failure

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002050048A1 (en) * 2000-12-20 2002-06-27 Glaxo Group Limited Thia- and oxazoles and their use as ppars activators
WO2002059098A1 (en) * 2000-12-20 2002-08-01 Glaxo Group Limited Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
EP1310494A1 (en) * 2000-08-11 2003-05-14 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
EP1371650A1 (en) * 2001-03-23 2003-12-17 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor
EP1424330A1 (en) * 2001-08-10 2004-06-02 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-responsive receptor delta
EP1666472A1 (en) * 2003-09-22 2006-06-07 Ono Pharmaceutical Co., Ltd. Phenylacetic acid derivative, process for producing the same, and use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1310494A1 (en) * 2000-08-11 2003-05-14 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
WO2002050048A1 (en) * 2000-12-20 2002-06-27 Glaxo Group Limited Thia- and oxazoles and their use as ppars activators
WO2002059098A1 (en) * 2000-12-20 2002-08-01 Glaxo Group Limited Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors
EP1371650A1 (en) * 2001-03-23 2003-12-17 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor
EP1424330A1 (en) * 2001-08-10 2004-06-02 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-responsive receptor delta
EP1666472A1 (en) * 2003-09-22 2006-06-07 Ono Pharmaceutical Co., Ltd. Phenylacetic acid derivative, process for producing the same, and use

Also Published As

Publication number Publication date
WO2008087367A2 (en) 2008-07-24
FR2910893A1 (en) 2008-07-04

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