[go: up one dir, main page]

WO2009069764A1 - Agent analgésique opioïde - Google Patents

Agent analgésique opioïde Download PDF

Info

Publication number
WO2009069764A1
WO2009069764A1 PCT/JP2008/071689 JP2008071689W WO2009069764A1 WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1 JP 2008071689 W JP2008071689 W JP 2008071689W WO 2009069764 A1 WO2009069764 A1 WO 2009069764A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
analgesic
analgesic agent
opioid analgesic
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/071689
Other languages
English (en)
Japanese (ja)
Inventor
Hiromitsu Takayama
Mariko Kitajima
Syunji Horie
Kenjiro Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiba University NUC
JOSAI UNIV CORP
Original Assignee
Chiba University NUC
JOSAI UNIV CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiba University NUC, JOSAI UNIV CORP filed Critical Chiba University NUC
Priority to JP2009543879A priority Critical patent/JP5308352B2/ja
Publication of WO2009069764A1 publication Critical patent/WO2009069764A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention vise à proposer un composé doté d'une activité analgésique ; une composition pharmaceutique et un agent analgésique, dont chacun comprend le composé ; un procédé de traitement analgésique utilisant le composé ; et l'utilisation du composé dans un traitement analgésique. L'invention porte sur un composé représenté par la formule (I) ou un sel de celui-ci. (I) dans laquelle R1 représente un atome d'hydrogène ou un atome d'halogène ; R2, R3, R4 et R5 représentent indépendamment un atome d'hydrogène, un groupe hydroxy, un groupe alcoxy qui peut avoir un substituant ou similaire ; et R6 représente un groupe alcoxycarbonyle qui peut avoir un substituant ou un groupe carboxy.
PCT/JP2008/071689 2007-11-30 2008-11-28 Agent analgésique opioïde Ceased WO2009069764A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009543879A JP5308352B2 (ja) 2007-11-30 2008-11-28 オピオイド鎮痛剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007310939 2007-11-30
JP2007-310939 2007-11-30

Publications (1)

Publication Number Publication Date
WO2009069764A1 true WO2009069764A1 (fr) 2009-06-04

Family

ID=40678653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071689 Ceased WO2009069764A1 (fr) 2007-11-30 2008-11-28 Agent analgésique opioïde

Country Status (2)

Country Link
JP (1) JP5308352B2 (fr)
WO (1) WO2009069764A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (ja) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ アロディニア、痛覚過敏、自発痛及び幻肢痛の処置
CN103588669A (zh) * 2013-10-28 2014-02-19 史克勇 一种具有缓解癌性疼痛活性的化合物
CN104016879A (zh) * 2014-05-30 2014-09-03 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用
WO2015064573A1 (fr) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 Analgésique opioïde

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09291091A (ja) * 1996-04-25 1997-11-11 Soyaku Gijutsu Kenkyusho:Kk インドールアルカロイド誘導体、その製造方法及び抗ウイルス剤
US8247428B2 (en) * 2007-11-08 2012-08-21 National University Corporation Chiba University Indole alkaloid derivatives having opioid receptor agonistic effect, and therapeutic compositions and methods relating to same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERLEM,D. ET AL.: "Photochemical oxidation of tertiary amines and alkaloids.XI. Sensitized photooxidation of corynantheidine. Transformation of corynantheine-type derivatives into sarpagine-type derivatives", TETRAHEDRON, vol. 38, no. 2, 1982, pages 271 - 278 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013543378A (ja) * 2010-10-01 2013-12-05 エヌエスジーン・アクティーゼルスカブ アロディニア、痛覚過敏、自発痛及び幻肢痛の処置
CN103588669A (zh) * 2013-10-28 2014-02-19 史克勇 一种具有缓解癌性疼痛活性的化合物
WO2015064573A1 (fr) * 2013-10-29 2015-05-07 国立大学法人 千葉大学 Analgésique opioïde
JPWO2015064573A1 (ja) * 2013-10-29 2017-03-09 国立大学法人 千葉大学 オピオイド鎮痛剤
CN104016879A (zh) * 2014-05-30 2014-09-03 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用
CN104016879B (zh) * 2014-05-30 2016-02-24 西安交通大学 具有抗肿瘤活性的联苯酰胺化合物及其制备方法和应用

Also Published As

Publication number Publication date
JP5308352B2 (ja) 2013-10-09
JPWO2009069764A1 (ja) 2011-04-21

Similar Documents

Publication Publication Date Title
WO2008099874A1 (fr) Composition pharmaceutique comportant un dérivé de pyrazine et procédé d'utilisation d'un dérivé de pyrazine en combinaison
WO2010021680A3 (fr) Inhibiteurs de la bêta-sécrétase
WO2008104175A3 (fr) Nouveaux inhibiteurs de la phosphodiestérase
TW200740776A (en) N-phenylbenzotriazolyl c-kit inhibitors
EP2288260A4 (fr) Composés triazolopyridine inhibiteurs de jak kinase et procédés
MX336271B (es) Compuestos de triazolopiridina inhibidores de jak y los metodos.
MX2010009736A (es) Compuesto heterociclico.
TNSN08407A1 (en) Organic compounds
WO2007138472A3 (fr) Dérivés de la triazolopyridazine
MX2009011997A (es) Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.
GEP20125537B (en) Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
WO2009026176A3 (fr) Composés de flavononol anti-infectieux et leurs procédés d'utilisation
TN2012000152A1 (en) Spiropiperidine compounds and pharmaceutical use thereof for treating diabetes
WO2005075425A3 (fr) Derives de bisaryluree
WO2008126831A1 (fr) Atropisomère de dérivé de pyrrole
MY145795A (en) Pyrazoline compounds
EP2639229A3 (fr) Dérivé de thiazole et son utilisation en tant qu'inhibiteur VAP-1
WO2008126901A1 (fr) Composé hétérocyclique contenant de l'azote et composition pharmaceutique le contenant
WO2009018065A3 (fr) Nouveaux activateurs de glucokinase et procédés pour les utiliser
ATE446089T1 (de) 2-benzoyl-imidazopyridin-derivate, herstellungsverfahren und ihre verwendung für therapeutika
WO2009041663A1 (fr) Agent destiné à la prévention et/ou au traitement de maladies cutanées
WO2008114812A1 (fr) Inhibiteur de jak
MX2010009756A (es) Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y proceso para preparacion de los mismos.
WO2008139845A1 (fr) Nouveau dérivé amide
WO2009069764A1 (fr) Agent analgésique opioïde

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08853495

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009543879

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08853495

Country of ref document: EP

Kind code of ref document: A1