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WO2009067600A3 - Biaryl pde4 inhibitors for treating inflammation - Google Patents

Biaryl pde4 inhibitors for treating inflammation Download PDF

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Publication number
WO2009067600A3
WO2009067600A3 PCT/US2008/084193 US2008084193W WO2009067600A3 WO 2009067600 A3 WO2009067600 A3 WO 2009067600A3 US 2008084193 W US2008084193 W US 2008084193W WO 2009067600 A3 WO2009067600 A3 WO 2009067600A3
Authority
WO
WIPO (PCT)
Prior art keywords
pde4 inhibitors
treating inflammation
biaryl
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/084193
Other languages
French (fr)
Other versions
WO2009067600A2 (en
Inventor
Jasbir Singh
Mark E Gurney
Alex Burgin
Vincent Sandanayaka
Alexander Kiselyov
Adalie Motta
Gary Schultz
Georgeta Hategan
Timothy Hagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Decode Genetics ehf
Original Assignee
Decode Genetics ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decode Genetics ehf filed Critical Decode Genetics ehf
Priority to AU2008326381A priority Critical patent/AU2008326381B2/en
Priority to JP2010535064A priority patent/JP2011505341A/en
Priority to EP08851045A priority patent/EP2222638A2/en
Priority to CA2722582A priority patent/CA2722582A1/en
Priority to PCT/US2008/084193 priority patent/WO2009067600A2/en
Priority to CN2008801251758A priority patent/CN102089279A/en
Publication of WO2009067600A2 publication Critical patent/WO2009067600A2/en
Publication of WO2009067600A3 publication Critical patent/WO2009067600A3/en
Priority to IL205881A priority patent/IL205881A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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Abstract

The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: (formula should be inserted here). A particular embodiment is (a second formula should be inserted here)
PCT/US2008/084193 2007-11-21 2008-11-20 Biaryl pde4 inhibitors for treating inflammation Ceased WO2009067600A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2008326381A AU2008326381B2 (en) 2007-11-21 2008-11-20 Biaryl PDE4 inhibitors for treating inflammation
JP2010535064A JP2011505341A (en) 2007-11-21 2008-11-20 Biaryl PDE4 inhibitors to treat inflammatory, cardiovascular and CNS disorders
EP08851045A EP2222638A2 (en) 2007-11-21 2008-11-20 Biaryl pde4 inhibitors for treating inflammation
CA2722582A CA2722582A1 (en) 2007-11-21 2008-11-20 Biaryl pde4 inhibitors for treating inflammation
PCT/US2008/084193 WO2009067600A2 (en) 2007-11-21 2008-11-20 Biaryl pde4 inhibitors for treating inflammation
CN2008801251758A CN102089279A (en) 2007-11-21 2008-11-20 Biaryl PDE4 inhibitors for treating inflammation
IL205881A IL205881A0 (en) 2008-11-20 2010-05-20 Biaryl pde4 inhibitors for treating inflammation

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US98955107P 2007-11-21 2007-11-21
US60/989,551 2007-11-21
PCT/US2008/084193 WO2009067600A2 (en) 2007-11-21 2008-11-20 Biaryl pde4 inhibitors for treating inflammation

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SRINIVASARAO ARULANANDA BABU, MAKOTO YASUDA, AND AKIO BABA: "In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe2SiH with Carboxylic Acids: Direct Chemo- and Regioselective Friedel?Crafts Acylation of Aromatic Ethers", ORGANIC LETTERS, vol. 9, no. 3, 12 January 2007 (2007-01-12), pages 405 - 408, XP002517831 *

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JP2011505341A (en) 2011-02-24
CA2722582A1 (en) 2009-05-28
AU2008326381A1 (en) 2009-05-28
AU2008326381B2 (en) 2014-10-23
CN102089279A (en) 2011-06-08
WO2009067600A2 (en) 2009-05-28

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