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WO2012046030A3 - Phosphodiesterase inhibitors - Google Patents

Phosphodiesterase inhibitors Download PDF

Info

Publication number
WO2012046030A3
WO2012046030A3 PCT/GB2011/051872 GB2011051872W WO2012046030A3 WO 2012046030 A3 WO2012046030 A3 WO 2012046030A3 GB 2011051872 W GB2011051872 W GB 2011051872W WO 2012046030 A3 WO2012046030 A3 WO 2012046030A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphodiesterase inhibitors
compounds
novel
variety
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2011/051872
Other languages
French (fr)
Other versions
WO2012046030A2 (en
Inventor
Sylvie Gomez Bateman
Ilona Jurkiewicz
Gesine Johanna Hermann
Ian Timothy William Matthews
Jonathan Peter Kirby
Elena Hernández LÓPEZ
Manisha Samar Kulkarni
Peter Edwards
William Richard King
Howard Christopher Thomas
Mark Richard Thursz
Israel Conesa Lerma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIOTECH PHARMACEUTICALS Ltd
Original Assignee
RIOTECH PHARMACEUTICALS Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIOTECH PHARMACEUTICALS Ltd filed Critical RIOTECH PHARMACEUTICALS Ltd
Publication of WO2012046030A2 publication Critical patent/WO2012046030A2/en
Publication of WO2012046030A3 publication Critical patent/WO2012046030A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel 2'5' –phosphodiesterase inhibitory compounds, to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of a variety of medical conditions.
PCT/GB2011/051872 2010-10-07 2011-10-03 Phosphodiesterase inhibitors Ceased WO2012046030A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39075910P 2010-10-07 2010-10-07
US61/390,759 2010-10-07
GB1016880.5 2010-10-07
GBGB1016880.5A GB201016880D0 (en) 2010-10-07 2010-10-07 Phosphodiesterase inhibitors

Publications (2)

Publication Number Publication Date
WO2012046030A2 WO2012046030A2 (en) 2012-04-12
WO2012046030A3 true WO2012046030A3 (en) 2012-08-09

Family

ID=43243648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/051872 Ceased WO2012046030A2 (en) 2010-10-07 2011-10-03 Phosphodiesterase inhibitors

Country Status (2)

Country Link
GB (1) GB201016880D0 (en)
WO (1) WO2012046030A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
JP5992054B2 (en) 2011-11-29 2016-09-14 ノバルティス アーゲー Pyrazolopyrrolidine compound
US8815926B2 (en) 2012-01-26 2014-08-26 Novartis Ag Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases
EP2855483B1 (en) 2012-05-24 2017-10-25 Novartis AG Pyrrolopyrrolidinone compounds
US9403827B2 (en) 2013-01-22 2016-08-02 Novartis Ag Substituted purinone compounds
EP2948453B1 (en) 2013-01-22 2017-08-02 Novartis AG Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
CN103819476B (en) * 2013-03-05 2016-08-17 中国人民解放军第二军医大学 Pyrrolidone pyrazole compound and the purposes as medicine thereof
US8975417B2 (en) * 2013-05-27 2015-03-10 Novartis Ag Pyrazolopyrrolidine derivatives and their use in the treatment of disease
WO2014191894A1 (en) 2013-05-27 2014-12-04 Novartis Ag Imidazopyrrolidinone derivatives and their use in the treatment of disease
KR20160012197A (en) 2013-05-28 2016-02-02 노파르티스 아게 Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
US9624247B2 (en) 2013-05-28 2017-04-18 Novartis Ag Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease
EP3071571A1 (en) 2013-11-21 2016-09-28 Novartis AG Pyrrolopyrrolone derivatives and their use as bet inhibitors
CN104876936B (en) * 2015-05-25 2018-01-30 中国人民解放军第二军医大学 The preparation of pyrrolones and pyrazole compound and the purposes as medicine
WO2019126431A1 (en) * 2017-12-22 2019-06-27 Chemocentryx, Inc. DIARYL SUBSTITUTED 5,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS
JP7413346B2 (en) * 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative
CN112142742B (en) * 2019-06-26 2022-01-07 香港理工大学深圳研究院 CTCF transcription factor inhibitor and application thereof
EP4281452A4 (en) * 2021-01-21 2024-11-06 Beijing Tiantan Hospital FPR1 MODULATORS AND METHODS OF USE THEREOF
EP4281453A4 (en) * 2021-01-21 2024-11-06 Biofront Therapeutics (Beijing) Co., Ltd. FPR1 MODULATORS AND METHODS OF USE THEREOF
GB202100976D0 (en) 2021-01-25 2021-03-10 Riotech Pharmaceuticals Ltd Treatment

Citations (5)

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WO1995019362A1 (en) * 1994-01-14 1995-07-20 Pfizer Inc. Dihydro pyrazolopyrroles
RU2320661C2 (en) * 2006-03-15 2008-03-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию Российской Федерации" (ГОУ ВПО ПГФА Росздрава) 1,4,5,6-tetrahydro-6-oxo-5-(2-piperazinoethyl)-4-phenyl-3-(4-chlorophenyl)pyrrolo[3.4-c]pyrazole dihydrochloride eliciting hypotensive and anti-coagulant activity
EP2143713A1 (en) * 2007-03-30 2010-01-13 Shionogi&Co., Ltd. Novel pyrrolinone derivative and medicinal composition containing the same
WO2010035727A1 (en) * 2008-09-25 2010-04-01 塩野義製薬株式会社 Novel pyrrolinone derivative and medicinal composition containing same
CA2686584A1 (en) * 2009-11-27 2011-05-27 Institut Pasteur Plasmodium proteases inhibitors and in silico screening methods for identifying the same

Family Cites Families (3)

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US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019362A1 (en) * 1994-01-14 1995-07-20 Pfizer Inc. Dihydro pyrazolopyrroles
RU2320661C2 (en) * 2006-03-15 2008-03-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию Российской Федерации" (ГОУ ВПО ПГФА Росздрава) 1,4,5,6-tetrahydro-6-oxo-5-(2-piperazinoethyl)-4-phenyl-3-(4-chlorophenyl)pyrrolo[3.4-c]pyrazole dihydrochloride eliciting hypotensive and anti-coagulant activity
EP2143713A1 (en) * 2007-03-30 2010-01-13 Shionogi&Co., Ltd. Novel pyrrolinone derivative and medicinal composition containing the same
WO2010035727A1 (en) * 2008-09-25 2010-04-01 塩野義製薬株式会社 Novel pyrrolinone derivative and medicinal composition containing same
CA2686584A1 (en) * 2009-11-27 2011-05-27 Institut Pasteur Plasmodium proteases inhibitors and in silico screening methods for identifying the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDREICHIKOV YU S ET AL: "Oxalyl derivatives of methyl ketones. XLIV. Synthesis of 4-aroyltetrahydro-1,5-diphenyl-2,3-pyrrolediones and their reaction with amines and hydrazine", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, CONSULTANTS BUREAU, US, vol. 22, no. 8, 1 January 1986 (1986-01-01), pages 1572 - 1577, XP009159741, ISSN: 1070-4280 *
GEIN V L ET AL: "Three-Component Condensation of Methyl Acylpyruvates with Aromatic Aldehydes and Ethylenediamine. Chemical Properties of the Products", RUSSIAN JOURNAL OF GENERAL CHEMISTRY, NAUKA/INTERPERIODICA, MO, vol. 75, no. 2, 1 February 2005 (2005-02-01), pages 254 - 260, XP019300997, ISSN: 1608-3350 *
M. DOHRN ET AL: "Über Pyrazo-pyrrolidone", BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1 January 1931 (1931-01-01), pages 2863 - 2865, XP055028210, Retrieved from the Internet <URL:http://onlinelibrary.wiley.com/store/10.1002/cber.19310641121/asset/19310641121_ftp.pdf?v=1&t=h2n9zorp&s=dc6066345bc10cad17cf507e10cf44518131328f> [retrieved on 20120525] *
V. L. GEIN ET AL: "Three-component reaction of methyl 2,4-dioxo-4-phenylbutanoate and methyl 2,4-dioxopentanoate with aromatic aldehydes and propane-1,2-diamine and chemical properties of the products", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 46, no. 6, 1 June 2010 (2010-06-01), pages 875 - 883, XP055028199, ISSN: 1070-4280, DOI: 10.1134/S1070428010060163 *

Also Published As

Publication number Publication date
WO2012046030A2 (en) 2012-04-12
GB201016880D0 (en) 2010-11-17

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