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WO2009048027A1 - 免疫関連遺伝子の多型の検出用プローブおよびその用途 - Google Patents

免疫関連遺伝子の多型の検出用プローブおよびその用途 Download PDF

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Publication number
WO2009048027A1
WO2009048027A1 PCT/JP2008/068090 JP2008068090W WO2009048027A1 WO 2009048027 A1 WO2009048027 A1 WO 2009048027A1 JP 2008068090 W JP2008068090 W JP 2008068090W WO 2009048027 A1 WO2009048027 A1 WO 2009048027A1
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WO
WIPO (PCT)
Prior art keywords
probe
seq
gene
polymorphism
detect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/068090
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English (en)
French (fr)
Inventor
Mitsuharu Hirai
Satoshi Majima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arkray Inc
Original Assignee
Arkray Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray Inc filed Critical Arkray Inc
Priority to KR1020097005150A priority Critical patent/KR101192008B1/ko
Priority to EP08837768A priority patent/EP2130917A4/en
Priority to JP2009504927A priority patent/JP5290957B2/ja
Priority to CN2008800116369A priority patent/CN101652478B/zh
Priority to US12/594,519 priority patent/US9157118B2/en
Publication of WO2009048027A1 publication Critical patent/WO2009048027A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/107—Temperature of melting, i.e. Tm
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

　一塩基のみが異なる多型を判別することが可能な多型の検出用プローブを提供する。 　配列番号４、２３、３０、４７、５７および６４からなる群から選択された少なくとも一つのオリゴヌクレオチドを、Ｔｍ解析におけるプローブとして使用する。これらのプローブを用いたＴｍ解析によれば、抗体医薬等の薬効に影響するＦＣＧＲ３Ａ遺伝子、ＦＣＧＲ２Ａ遺伝子、ＩＬ－１０遺伝子、ＴＮＦα遺伝子およびＴＮＦβ遺伝子の特定の多型を簡便に検出できる。また、これらのプローブによれば、反応系に二種類以上の前記プローブを共存させることによって、同一反応系において二種類以上の多型を検出できる。
PCT/JP2008/068090 2007-10-09 2008-10-03 免疫関連遺伝子の多型の検出用プローブおよびその用途 Ceased WO2009048027A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020097005150A KR101192008B1 (ko) 2007-10-09 2008-10-03 면역 관련 유전자의 다형의 검출용 프로브 및 그 용도
EP08837768A EP2130917A4 (en) 2007-10-09 2008-10-03 PROBE FOR DETECTING POLYMORPHISM IN A GENE INVOLVED IN IMMUNITY AND USE THEREOF
JP2009504927A JP5290957B2 (ja) 2007-10-09 2008-10-03 免疫関連遺伝子の多型の検出用プローブおよびその用途
CN2008800116369A CN101652478B (zh) 2007-10-09 2008-10-03 免疫相关基因的多态性的检测用探针及其用途
US12/594,519 US9157118B2 (en) 2007-10-09 2008-10-03 Probes for detecting immune-related gene polymorphisms and applications of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-263713 2007-10-09
JP2007263713 2007-10-09

Publications (1)

Publication Number Publication Date
WO2009048027A1 true WO2009048027A1 (ja) 2009-04-16

Family

ID=40549173

Family Applications (1)

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PCT/JP2008/068090 Ceased WO2009048027A1 (ja) 2007-10-09 2008-10-03 免疫関連遺伝子の多型の検出用プローブおよびその用途

Country Status (6)

Country Link
US (1) US9157118B2 (ja)
EP (1) EP2130917A4 (ja)
JP (1) JP5290957B2 (ja)
KR (1) KR101192008B1 (ja)
CN (1) CN101652478B (ja)
WO (1) WO2009048027A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120124029A (ko) * 2011-05-02 2012-11-12 아크레이 가부시키가이샤 다형 검출용 프로브, 다형 검출 방법, 약효 판정 방법 및 다형 검출용 시약 키트

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012061814A1 (en) * 2010-11-05 2012-05-10 Transgenomic, Inc. Pcr primers and methods for rapid and specific genotyping
CN103276078B (zh) * 2013-05-28 2014-11-05 中国人民解放军第三军医大学第三附属医院 细胞因子基因snp遗传标记检测试剂盒及其使用方法
CA3012815C (en) * 2016-02-09 2021-09-28 Eiken Kagaku Kabushiki Kaisha Method for detecting target nucleic acid and nucleic acid probe used therein
JP7025342B2 (ja) * 2016-10-26 2022-02-24 栄研化学株式会社 標的塩基配列を検出する方法、プローブを設計および製造する方法ならびにキット
CN106399582B (zh) * 2016-12-20 2019-12-24 上海杏园瑞民生物工程有限公司 一种检测与结直肠癌靶向用药西妥昔单抗治疗敏感性相关基因的多态性的试剂盒及其应用
WO2019013613A2 (es) * 2017-07-09 2019-01-17 Hakken Enterprise Sa De Cv Métodos y kits para determinar el riesgo de cáncer
CN108330180A (zh) * 2017-10-25 2018-07-27 广州和康医疗技术有限公司 一种对fcgr3a位点进行基因型检测的方法及试剂盒

Citations (1)

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WO2005123947A1 (en) 2004-06-15 2005-12-29 Universite Francois Rabelais Methods of assessing susceptibility to drug-induced thrombocytopenia

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WO2005118854A1 (en) 2004-06-01 2005-12-15 Centre Hospitalier Regional Et Universitaire De Tours Fcgr3a gebotype and methods for evaluating treatment response to non-depleting antibodies
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GB0510790D0 (en) * 2005-05-26 2005-06-29 Syngenta Crop Protection Ag Anti-CD16 binding molecules
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"Dai 28 Kai Annual Meeting of the Molecular Biology Society of Japan Koen Yoshishu", 2005, article YUKARI KUREBAYASHI ET AL.: "Zenjido Idenshi Kaiseki Sochi o Mochiita Hito CYP2C19 no Iden Takei Kaiseki to Shinki Kaiseki System o Mochiita Databese no Kaihat", pages: 742, XP008116988 *
BUILLAUME CARTRON ET AL., BLOOD, vol. 99, no. 3, 1 February 2002 (2002-02-01)
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HATJIHARISSI E. ET AL: "Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the Fc?gamma? RIIIa-158 V/V and V/F polymorphism.", BLOOD, vol. 110, no. 7, 1 October 2007 (2007-10-01), pages 2561 - 2564, XP008117815 *
JUN'YA KURODA ET AL.: "Shinki Jinsokuten Totsuzen Hen'i Kenshutsuho ni yoru Zoketsuki Shuyo no Tailor-made Chiryo Senryaku", THE JOURNAL OF THE JAPAN SOCIETY FOR CANCER THERAPY, vol. 42, no. 2, September 2007 (2007-09-01), pages 311, XP008117824 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120124029A (ko) * 2011-05-02 2012-11-12 아크레이 가부시키가이샤 다형 검출용 프로브, 다형 검출 방법, 약효 판정 방법 및 다형 검출용 시약 키트
KR101581388B1 (ko) 2011-05-02 2015-12-30 아크레이 가부시키가이샤 다형 검출용 프로브, 다형 검출 방법, 약효 판정 방법 및 다형 검출용 시약 키트

Also Published As

Publication number Publication date
KR20090052353A (ko) 2009-05-25
US9157118B2 (en) 2015-10-13
JP5290957B2 (ja) 2013-09-18
EP2130917A4 (en) 2010-09-01
CN101652478A (zh) 2010-02-17
CN101652478B (zh) 2013-03-27
US20100047806A1 (en) 2010-02-25
JPWO2009048027A1 (ja) 2011-02-17
EP2130917A1 (en) 2009-12-09
KR101192008B1 (ko) 2012-11-02

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