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WO2009048073A1 - Procédé d'enrobage de granules - Google Patents

Procédé d'enrobage de granules Download PDF

Info

Publication number
WO2009048073A1
WO2009048073A1 PCT/JP2008/068291 JP2008068291W WO2009048073A1 WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1 JP 2008068291 W JP2008068291 W JP 2008068291W WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
coating
organic solvent
active substance
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/068291
Other languages
English (en)
Japanese (ja)
Inventor
Muneo Nonomura
Yusuke Murakawa
Naoki Nagahara
Hiroshi Fukada
Tetsuro Tabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of WO2009048073A1 publication Critical patent/WO2009048073A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Cette invention concerne un procédé d'enrobage dans lequel le profil d'élution de l'agent principal des granules contenant une substance physiologiquement active est contrôlé en recouvrant des noyaux contenant la substance physiologiquement active par pulvérisation d'une solution d'enrobage qui contient un polymère insoluble dans l'eau, un solvant organique ayant un point d'ébullition d'au moins 50 °C et de l'eau où le rapport des teneurs en poids du solvant organique sur l'eau vaut environ 89/11 à environ 50/50.
PCT/JP2008/068291 2007-10-09 2008-10-08 Procédé d'enrobage de granules Ceased WO2009048073A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007263185 2007-10-09
JP2007-263185 2007-10-09

Publications (1)

Publication Number Publication Date
WO2009048073A1 true WO2009048073A1 (fr) 2009-04-16

Family

ID=40549217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068291 Ceased WO2009048073A1 (fr) 2007-10-09 2008-10-08 Procédé d'enrobage de granules

Country Status (1)

Country Link
WO (1) WO2009048073A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010280589A (ja) * 2009-06-03 2010-12-16 Ohara Yakuhin Kogyo Kk 生理活性物質含有粒子の製造方法
JP2012046454A (ja) * 2010-08-27 2012-03-08 Lion Corp 内服用錠剤およびその製造方法
WO2018045103A1 (fr) * 2016-08-30 2018-03-08 Allergan, Inc. Procédé de fabrication de billes enrobées
US11078085B2 (en) 2016-05-26 2021-08-03 Allergan, Inc. Production of rounded salt particles
WO2023209606A1 (fr) * 2022-04-29 2023-11-02 Illumina Cambridge Limited Procédés et systèmes d'encapsulation de microsphères lyophilisées

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021405A (ja) * 1988-03-31 1990-01-05 Tanabe Seiyaku Co Ltd 放出制御型製剤およびその製法
JPH05194225A (ja) * 1991-11-07 1993-08-03 Yoshitomi Pharmaceut Ind Ltd 安定化された抗潰瘍剤含有製剤
WO1994010983A1 (fr) * 1992-11-06 1994-05-26 Hisamitsu Pharmaceutical Co., Inc. Preparation pharmaceutique perorale liberable dans le tube digestif inferieur
JPH08109126A (ja) * 1994-10-07 1996-04-30 Amano Pharmaceut Co Ltd 耐衝撃性腸溶性顆粒剤およびこれを含有する錠剤
JPH08259446A (ja) * 1995-01-24 1996-10-08 Mitsui Toatsu Chem Inc 持効性医薬製剤
JPH09295933A (ja) * 1996-03-07 1997-11-18 Takeda Chem Ind Ltd 放出制御組成物
JPH10231242A (ja) * 1997-02-20 1998-09-02 Taiyo Yakuhin Kogyo Kk 持続性ジクロフェナクナトリウム組成物
JP2002363080A (ja) * 2001-06-08 2002-12-18 Towa Yakuhin Kk 安定な内服用抗潰瘍製剤の製造法
JP2007519741A (ja) * 2004-01-29 2007-07-19 ヤマノウチ・ファーマ・テクノロジーズ・インク 胃腸特異的複数薬物放出システム

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021405A (ja) * 1988-03-31 1990-01-05 Tanabe Seiyaku Co Ltd 放出制御型製剤およびその製法
JPH05194225A (ja) * 1991-11-07 1993-08-03 Yoshitomi Pharmaceut Ind Ltd 安定化された抗潰瘍剤含有製剤
WO1994010983A1 (fr) * 1992-11-06 1994-05-26 Hisamitsu Pharmaceutical Co., Inc. Preparation pharmaceutique perorale liberable dans le tube digestif inferieur
JPH08109126A (ja) * 1994-10-07 1996-04-30 Amano Pharmaceut Co Ltd 耐衝撃性腸溶性顆粒剤およびこれを含有する錠剤
JPH08259446A (ja) * 1995-01-24 1996-10-08 Mitsui Toatsu Chem Inc 持効性医薬製剤
JPH09295933A (ja) * 1996-03-07 1997-11-18 Takeda Chem Ind Ltd 放出制御組成物
JPH10231242A (ja) * 1997-02-20 1998-09-02 Taiyo Yakuhin Kogyo Kk 持続性ジクロフェナクナトリウム組成物
JP2002363080A (ja) * 2001-06-08 2002-12-18 Towa Yakuhin Kk 安定な内服用抗潰瘍製剤の製造法
JP2007519741A (ja) * 2004-01-29 2007-07-19 ヤマノウチ・ファーマ・テクノロジーズ・インク 胃腸特異的複数薬物放出システム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010280589A (ja) * 2009-06-03 2010-12-16 Ohara Yakuhin Kogyo Kk 生理活性物質含有粒子の製造方法
JP2012046454A (ja) * 2010-08-27 2012-03-08 Lion Corp 内服用錠剤およびその製造方法
US11078085B2 (en) 2016-05-26 2021-08-03 Allergan, Inc. Production of rounded salt particles
WO2018045103A1 (fr) * 2016-08-30 2018-03-08 Allergan, Inc. Procédé de fabrication de billes enrobées
WO2023209606A1 (fr) * 2022-04-29 2023-11-02 Illumina Cambridge Limited Procédés et systèmes d'encapsulation de microsphères lyophilisées

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