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WO2009048073A1 - Method of coating granules - Google Patents

Method of coating granules Download PDF

Info

Publication number
WO2009048073A1
WO2009048073A1 PCT/JP2008/068291 JP2008068291W WO2009048073A1 WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1 JP 2008068291 W JP2008068291 W JP 2008068291W WO 2009048073 A1 WO2009048073 A1 WO 2009048073A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
coating
organic solvent
active substance
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/068291
Other languages
French (fr)
Japanese (ja)
Inventor
Muneo Nonomura
Yusuke Murakawa
Naoki Nagahara
Hiroshi Fukada
Tetsuro Tabata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of WO2009048073A1 publication Critical patent/WO2009048073A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

It is intended to provide a coating method wherein the elution profile of the principle agent from granules containing a physiologically active substance is controlled by coating cores containing the physiologically active substance by spraying thereto a coating solution which contains a water-insoluble polymer, an organic solvent having a boiling point of 50oC or higher and water and in which the content ratio by weight of the organic solvent to the water is about 89/11 to about 50/50.
PCT/JP2008/068291 2007-10-09 2008-10-08 Method of coating granules Ceased WO2009048073A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007263185 2007-10-09
JP2007-263185 2007-10-09

Publications (1)

Publication Number Publication Date
WO2009048073A1 true WO2009048073A1 (en) 2009-04-16

Family

ID=40549217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068291 Ceased WO2009048073A1 (en) 2007-10-09 2008-10-08 Method of coating granules

Country Status (1)

Country Link
WO (1) WO2009048073A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010280589A (en) * 2009-06-03 2010-12-16 Ohara Yakuhin Kogyo Kk Method for producing particles containing bioactive substance
JP2012046454A (en) * 2010-08-27 2012-03-08 Lion Corp Tablet for internal use and method for producing the same
WO2018045103A1 (en) * 2016-08-30 2018-03-08 Allergan, Inc. Method of manufacturing coated beads
US11078085B2 (en) 2016-05-26 2021-08-03 Allergan, Inc. Production of rounded salt particles
WO2023209606A1 (en) * 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021405A (en) * 1988-03-31 1990-01-05 Tanabe Seiyaku Co Ltd Preparation of release control type and production thereof
JPH05194225A (en) * 1991-11-07 1993-08-03 Yoshitomi Pharmaceut Ind Ltd Stabilized anti-ulcer drug-containing preparation
WO1994010983A1 (en) * 1992-11-06 1994-05-26 Hisamitsu Pharmaceutical Co., Inc. Peroral pharmaceutical preparation releasable in lower digestive tract
JPH08109126A (en) * 1994-10-07 1996-04-30 Amano Pharmaceut Co Ltd Impact resistant enteric coated granules and tablets containing the same
JPH08259446A (en) * 1995-01-24 1996-10-08 Mitsui Toatsu Chem Inc Long-acting pharmaceutical preparation
JPH09295933A (en) * 1996-03-07 1997-11-18 Takeda Chem Ind Ltd Composition for controlling release purpose
JPH10231242A (en) * 1997-02-20 1998-09-02 Taiyo Yakuhin Kogyo Kk Long-acting diclofenac sodium composition
JP2002363080A (en) * 2001-06-08 2002-12-18 Towa Yakuhin Kk Method for producing stable oral anti-ulcer preparation
JP2007519741A (en) * 2004-01-29 2007-07-19 ヤマノウチ・ファーマ・テクノロジーズ・インク Gastrointestinal specific multiple drug release system

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH021405A (en) * 1988-03-31 1990-01-05 Tanabe Seiyaku Co Ltd Preparation of release control type and production thereof
JPH05194225A (en) * 1991-11-07 1993-08-03 Yoshitomi Pharmaceut Ind Ltd Stabilized anti-ulcer drug-containing preparation
WO1994010983A1 (en) * 1992-11-06 1994-05-26 Hisamitsu Pharmaceutical Co., Inc. Peroral pharmaceutical preparation releasable in lower digestive tract
JPH08109126A (en) * 1994-10-07 1996-04-30 Amano Pharmaceut Co Ltd Impact resistant enteric coated granules and tablets containing the same
JPH08259446A (en) * 1995-01-24 1996-10-08 Mitsui Toatsu Chem Inc Long-acting pharmaceutical preparation
JPH09295933A (en) * 1996-03-07 1997-11-18 Takeda Chem Ind Ltd Composition for controlling release purpose
JPH10231242A (en) * 1997-02-20 1998-09-02 Taiyo Yakuhin Kogyo Kk Long-acting diclofenac sodium composition
JP2002363080A (en) * 2001-06-08 2002-12-18 Towa Yakuhin Kk Method for producing stable oral anti-ulcer preparation
JP2007519741A (en) * 2004-01-29 2007-07-19 ヤマノウチ・ファーマ・テクノロジーズ・インク Gastrointestinal specific multiple drug release system

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010280589A (en) * 2009-06-03 2010-12-16 Ohara Yakuhin Kogyo Kk Method for producing particles containing bioactive substance
JP2012046454A (en) * 2010-08-27 2012-03-08 Lion Corp Tablet for internal use and method for producing the same
US11078085B2 (en) 2016-05-26 2021-08-03 Allergan, Inc. Production of rounded salt particles
WO2018045103A1 (en) * 2016-08-30 2018-03-08 Allergan, Inc. Method of manufacturing coated beads
WO2023209606A1 (en) * 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres

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