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WO2009047669A2 - Dentifrice activé par la lumière et brosse à dents à projection de lumière associée - Google Patents

Dentifrice activé par la lumière et brosse à dents à projection de lumière associée Download PDF

Info

Publication number
WO2009047669A2
WO2009047669A2 PCT/IB2008/054000 IB2008054000W WO2009047669A2 WO 2009047669 A2 WO2009047669 A2 WO 2009047669A2 IB 2008054000 W IB2008054000 W IB 2008054000W WO 2009047669 A2 WO2009047669 A2 WO 2009047669A2
Authority
WO
WIPO (PCT)
Prior art keywords
light
dentifrice
tio
tin
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/054000
Other languages
English (en)
Other versions
WO2009047669A3 (fr
Inventor
Yukiko Furukawa
Bart Gottenbos
Jozef Johannes Maria Janssen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
US Philips Corp
Original Assignee
Koninklijke Philips Electronics NV
US Philips Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV, US Philips Corp filed Critical Koninklijke Philips Electronics NV
Publication of WO2009047669A2 publication Critical patent/WO2009047669A2/fr
Anticipated expiration legal-status Critical
Publication of WO2009047669A3 publication Critical patent/WO2009047669A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0016—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means
    • A46B15/0034—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means with a source of radiation, e.g. UV, IR, LASER, X-ray for irradiating the teeth and associated surfaces
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B15/00—Other brushes; Brushes with additional arrangements
    • A46B15/0002—Arrangements for enhancing monitoring or controlling the brushing process
    • A46B15/0016—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means
    • A46B15/0036—Arrangements for enhancing monitoring or controlling the brushing process with enhancing means with a lighting means, e.g. laser, bulb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B2200/00—Brushes characterized by their functions, uses or applications
    • A46B2200/10—For human or animal care
    • A46B2200/1066—Toothbrush for cleaning the teeth or dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Definitions

  • This invention relates generally to dentifrices and more specifically concerns a light- activated dentifrice for killing oral bacteria and the combination of such a dentifrice with a light irradiating toothbrush.
  • Titanium Oxide (TiO 2 ) is one example of such a material.
  • UV light ultraviolet
  • An oral care combination which comprises: a treatment device having a source of light in the visible spectrum, safe for use in the mouth, and capable of activating photocatalysts to kill oral bacteria; and a dentifrice for use with the treatment device, comprising as one ingredient thereof photoactive particles comprising a core substantially of titanium nitride (TiN) and a shell of titanium oxide (TiO 2 ), wherein the relative amounts of TiN and TiO 2 in the active particles are such that the light activates the TiO 2 to the extent that substantially more than 50% of the oral bacteria coming into contact with the dentifrice and exposed to the light for a selected time are killed.
  • a treatment device having a source of light in the visible spectrum, safe for use in the mouth, and capable of activating photocatalysts to kill oral bacteria
  • a dentifrice for use with the treatment device comprising as one ingredient thereof photoactive particles comprising a core substantially of titanium nitride (TiN) and a shell of titanium oxide (TiO
  • a dentifrice which comprises: a mixture comprising a liquid medium and a powder comprising particles having a core of titanium nitride (TiN) and an outer shell of titanium oxide (TiO 2 ), the particles responding to light in the visible spectrum to kill oral bacteria when the mixture is used in the mouth.
  • a method for making a powder for use in a dentifrice for killing oral bacterial irradiated by light in the visible spectrum, longer in wavelength than ultraviolet light comprising the steps of: oxidizing a particle of original TiN material sufficiently to produce an end particle comprising a core of TiN and a shell of
  • FIG. 1 is an elevational view of a treatment device/toothbrush capable of emitting visible light in combination with a particular dentifrice in a conventional dentifrice tube.
  • Figure 2 is an elevational view showing a treatment device/toothbrush arrangement capable of emitting visible light for activating a particular dentifrice which is stored in the device/toothbrush itself.
  • Figure 3 is a diagram illustrating the effectiveness of two dentifrice embodiments in killing oral bacteria.
  • Figure 4 is a top plan view of a portion of a mouthguard using the particular dentifrice and visible light sources.
  • Figure 5 is a diagram of a particle used in the dentifrice.
  • Titanium Oxide (TiO 2 ) is known to function as a photocatalyst under ultraviolet light (UV). Under UV irradiation, it acts as a strong oxidant and can oxidize organic material directly. Further, as TiO 2 is exposed to UV light, it becomes increasingly hydrophilic and can be used in a number of general cleaning applications, as well as for killing bacteria, including oral bacteria. Hence, TiO 2 could be used as a component in oral care compositions such as toothpaste, mouthwash and whitening coatings for teeth.
  • the actual use of TiO 2 in oral care is extremely limited, because, as noted above, it requires the use of ultraviolet light, which is subject to safety concerns, including the possibility of inducing oral cancers with extended use. Heretofore, visible light, which is safe for use in the mouth, could not be used to activate TiO 2 .
  • a dentifrice powder is used for oral care applications which comprises particles 13 which have a titanium nitride (TiN) core 15 and a TiO 2 shell 17 around the TiN core.
  • TiN titanium nitride
  • Such a particle can be readily produced by partially oxidizing a TiN particle to produce an outer shell of TiO 2 around a remaining inner core of TiN.
  • the individual particles comprise 4% TiN and 96% TiO 2 by weight.
  • the particles of this embodiment absorb light having wavelengths less than 550nm, which is higher than the wavelength of ultraviolet light, which is less than 400nm.
  • the particles of another embodiment comprise 84% TiN and 16% TiO 2 which absorb visible light having wavelengths less than 850nm. Both of the above particles, but especially the higher TiN content embodiment, absorb a wide range of visible light having wavelengths greater than 400nm. Both of the above powder particles, when used in a dentifrice, have been shown to be effective in killing bacteria when irradiated with visible light at the wavelengths noted above. In one dentifrice arrangement, the powder particles are used in a water suspension with a powder concentration of 5-100mg/l. Different powder mixtures can, however, be used.
  • FIG. 1 shows an oral treatment device 10.
  • Treatment device 10 includes a light source 12 which can be located in a head portion 14, or in a handle portion 16. In the handle embodiment, light proceeds through a light pipe to and then out from head portion 14. On-off button 24 controls the operation of light source 12.
  • Treatment device 10 can include bristles 18 for scrubbing of the teeth, if desired. Bristles, however, are not necessary for effective operation of the treatment device.
  • Device 10 can be a manual toothbrush, or it could be a power toothbrush which provides a desired motion to the toothbrush head portion, including, for instance, lateral
  • the user applies a desired amount of dentifrice to a section of teeth.
  • the user can use the brush to scrub the teeth, if desired.
  • the light source is then actuated by operation of switch 24.
  • the light irradiates the dentifrice to kill the oral bacteria.
  • the visible light produced by the light source is advantageously absorbed by the TiN core and then transferred to the TiO 2 shell, activating the TiO 2 material, which produces the desired killing effect on the oral bacteria.
  • the present particle arrangement results in the TiO 2 being activated by the use of visible light. Since the light is in the visible spectrum, using dental approved LEDs, no harm is done to the user.
  • Figure 2 shows another treatment device embodiment 30, in which a source of dentifrice 32 is contained within handle 34 of the device.
  • a source of dentifrice 32 is contained within handle 34 of the device.
  • the dentifrice is directed to the teeth through openings 38 in the head portion 40 of the treatment device.
  • the embodiment of Figure 2 can use light activation alone, or bristles could be provided on the head portion for scrubbing of the teeth, with the toothbrush being manually or power operated.
  • the light source is actuated by on-off button switch 42.
  • Motion can be provided to the head portion 40 by a motor/driver 44, controlled by a button witch 46.
  • the time of light exposure to produce the desired killing rates could be 2 seconds per tooth, and several minutes, up to 10 or even 15 minutes, for the whole mouth, although 2-5 minutes would be more typical.
  • Figures 1 and 2 show hand-held treatment device embodiments, another useful embodiment could be in the form of a fully illuminating mouthguard, which treats all of the teeth at the same time.
  • the dentifrice composition with the TiNVTiO 2 particles could be positioned in the mouthguard before use.
  • This embodiment is illustrated in Figure 4, which shows a mouthguard portion 50, i.e. a lower half of a full mouthguard, with a light source 52 and an on-off control button 54.
  • the light source 54 is connected via a light pipe or similar element 56 to a plurality of light outlets 58-58 in the body of the mouthguard.
  • the entire mouth could be treated in a very short time, e.g. 2 minutes or less, depending on the arrangement of light sources in the mouthguard.
  • the light source could also be located away from the mouthguard itself, with the light proceeding through a flexible light tube to the mouthguard.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dentistry (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Brushes (AREA)

Abstract

L'invention concerne une combinaison d'un dispositif de traitement (10) comportant une source de lumière située dans une partie d'extrémité de tête, laquelle émet une lumière comprise dans la plage de la lumière visible, à utiliser à l'intérieur de la bouche avec un dentifrice (21) qui comprend un mélange constitué d'un milieu liquide et d'une poudre comprenant des particules (13) présentant un noyau en nitrure de titane (TiN) (15) avec une enveloppe extérieure en oxyde de titane (TiO2) (17). Le mélange, lorsqu'il est appliqué aux dents et qu'il est éclairé par la source de lumière dans la bouche, a pour conséquence l'activation du TiO2, ce par quoi jusqu'à 90 %, et plus, des bactéries buccales en contact avec le dentifrice et exposées à la lumière sont tuées au cours d'une période de temps donnée.
PCT/IB2008/054000 2007-10-08 2008-10-01 Dentifrice activé par la lumière et brosse à dents à projection de lumière associée Ceased WO2009047669A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97829007P 2007-10-08 2007-10-08
US60/978,290 2007-10-08

Publications (2)

Publication Number Publication Date
WO2009047669A2 true WO2009047669A2 (fr) 2009-04-16
WO2009047669A3 WO2009047669A3 (fr) 2010-09-30

Family

ID=40549669

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/054000 Ceased WO2009047669A2 (fr) 2007-10-08 2008-10-01 Dentifrice activé par la lumière et brosse à dents à projection de lumière associée

Country Status (1)

Country Link
WO (1) WO2009047669A2 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011084746A1 (fr) * 2009-12-21 2011-07-14 Colgate-Palmolive Company Kit contenant des colorants photosensibilisants
EP2545805A1 (fr) * 2011-07-11 2013-01-16 SRI France Ensemble pour un dispositif de dégraissage d'une pièce mécanique
USD723282S1 (en) 2014-03-17 2015-03-03 Gosmile, Inc. Toothbrush head
USD776936S1 (en) 2015-06-23 2017-01-24 Gosmile, Llc Toothbrush head
USD778061S1 (en) 2015-06-23 2017-02-07 Gosmile, Llc. Toothbrush
WO2017030768A1 (fr) * 2015-08-18 2017-02-23 L'oreal Applicateur de formulation photo-activable
USD787189S1 (en) 2014-03-17 2017-05-23 Gosmile, Llc Toothbrush
US10405638B2 (en) 2015-08-18 2019-09-10 L'oreal Connected photo-activatable formulation applicator
US10702055B2 (en) 2015-12-28 2020-07-07 Colgate-Palmolive Company Light emitting oral care implement
US11147984B2 (en) 2020-03-19 2021-10-19 Know Bio, Llc Illumination devices for inducing biological effects
US11524173B2 (en) 2015-07-28 2022-12-13 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US11654294B2 (en) 2021-03-15 2023-05-23 Know Bio, Llc Intranasal illumination devices
US11986666B2 (en) 2020-03-19 2024-05-21 Know Bio, Llc Illumination devices for inducing biological effects
US12011611B2 (en) 2020-03-19 2024-06-18 Know Bio, Llc Illumination devices for inducing biological effects
US12029914B2 (en) 2015-07-28 2024-07-09 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12115384B2 (en) 2021-03-15 2024-10-15 Know Bio, Llc Devices and methods for illuminating tissue to induce biological effects
US12347337B2 (en) 2020-12-10 2025-07-01 Know Bio, Llc Enhanced testing and characterization techniques for phototherapeutic light treatments
US12447354B2 (en) 2020-03-19 2025-10-21 Know Bio, Llc Illumination devices for inducing biological effects

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6011411A (ja) * 1983-06-30 1985-01-21 Yoshinori Nakagawa 歯磨剤
ATE398439T1 (de) * 2003-03-10 2008-07-15 G C Dental Ind Corp Kit mit dentalem bleichmittel und verfahren zum bleichen von zähnen

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102652028A (zh) * 2009-12-21 2012-08-29 高露洁-棕榄公司 含有光敏染料的试剂盒
AU2010339766B2 (en) * 2009-12-21 2013-03-14 Colgate-Palmolive Company Kit containing photosensitizing dyes
US9211420B2 (en) 2009-12-21 2015-12-15 Colgate-Palmolive Company Kit containing photosensitizing dyes
WO2011084746A1 (fr) * 2009-12-21 2011-07-14 Colgate-Palmolive Company Kit contenant des colorants photosensibilisants
EP2545805A1 (fr) * 2011-07-11 2013-01-16 SRI France Ensemble pour un dispositif de dégraissage d'une pièce mécanique
FR2977774A1 (fr) * 2011-07-11 2013-01-18 Sri France Ensemble pour un dispositif de degraissage d'une piece mecanique
USD787189S1 (en) 2014-03-17 2017-05-23 Gosmile, Llc Toothbrush
USD723282S1 (en) 2014-03-17 2015-03-03 Gosmile, Inc. Toothbrush head
USD776936S1 (en) 2015-06-23 2017-01-24 Gosmile, Llc Toothbrush head
USD778061S1 (en) 2015-06-23 2017-02-07 Gosmile, Llc. Toothbrush
US12029914B2 (en) 2015-07-28 2024-07-09 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12440697B2 (en) 2015-07-28 2025-10-14 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US11524173B2 (en) 2015-07-28 2022-12-13 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US11617895B2 (en) 2015-07-28 2023-04-04 Know Bio, Llc Systems and methods for phototherapeutic modulation of nitric oxide
US12397169B2 (en) 2015-07-28 2025-08-26 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12179035B2 (en) 2015-07-28 2024-12-31 Know Bio, Llc Phototherapeutic light for treatment of pathogens
US12109429B2 (en) 2015-07-28 2024-10-08 Know Bio, Llc Phototherapeutic light for treatment of pathogens
WO2017030768A1 (fr) * 2015-08-18 2017-02-23 L'oreal Applicateur de formulation photo-activable
US10405638B2 (en) 2015-08-18 2019-09-10 L'oreal Connected photo-activatable formulation applicator
US10842241B2 (en) 2015-08-18 2020-11-24 L'oreal Photo-activatable formulation applicator
US11457719B2 (en) 2015-08-18 2022-10-04 L'oreal Connected photo-activatable formulation applicator
US10034530B2 (en) 2015-08-18 2018-07-31 L'oreal Photo-activatable formulation applicator
US10702055B2 (en) 2015-12-28 2020-07-07 Colgate-Palmolive Company Light emitting oral care implement
US11752359B2 (en) 2020-03-19 2023-09-12 Know Bio, Llc Illumination devices for inducing biological effects
US12011611B2 (en) 2020-03-19 2024-06-18 Know Bio, Llc Illumination devices for inducing biological effects
US11986666B2 (en) 2020-03-19 2024-05-21 Know Bio, Llc Illumination devices for inducing biological effects
US11684798B2 (en) 2020-03-19 2023-06-27 Know Bio, Llc Illumination devices for inducing biological effects
US12390657B2 (en) 2020-03-19 2025-08-19 Know Bio, Llc Illumination devices for inducing biological effects
US11147984B2 (en) 2020-03-19 2021-10-19 Know Bio, Llc Illumination devices for inducing biological effects
US12447354B2 (en) 2020-03-19 2025-10-21 Know Bio, Llc Illumination devices for inducing biological effects
US12347337B2 (en) 2020-12-10 2025-07-01 Know Bio, Llc Enhanced testing and characterization techniques for phototherapeutic light treatments
US12115384B2 (en) 2021-03-15 2024-10-15 Know Bio, Llc Devices and methods for illuminating tissue to induce biological effects
US11654294B2 (en) 2021-03-15 2023-05-23 Know Bio, Llc Intranasal illumination devices

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