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WO2008139855A1 - Lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire - Google Patents

Lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire Download PDF

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Publication number
WO2008139855A1
WO2008139855A1 PCT/JP2008/057773 JP2008057773W WO2008139855A1 WO 2008139855 A1 WO2008139855 A1 WO 2008139855A1 JP 2008057773 W JP2008057773 W JP 2008057773W WO 2008139855 A1 WO2008139855 A1 WO 2008139855A1
Authority
WO
WIPO (PCT)
Prior art keywords
acyl group
lower acyl
lipid containing
polyamidoamine dendron
containing lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/057773
Other languages
English (en)
Japanese (ja)
Inventor
Kenji Kono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katayama Chemical Industries Co Ltd
Osaka Metropolitan University
Original Assignee
Osaka Prefecture University PUC
Katayama Chemical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka Prefecture University PUC, Katayama Chemical Industries Co Ltd filed Critical Osaka Prefecture University PUC
Publication of WO2008139855A1 publication Critical patent/WO2008139855A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)

Abstract

La présente invention concerne un lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire, qui est obtenu en substituant un ou des groupes amino dans un lipide portant des dendrimères polyamidoamine avec un groupe acyle de faible poids moléculaire ayant de 3 à 6 atomes de carbone. L'invention concerne également un procédé de production d'un tel lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire.
PCT/JP2008/057773 2007-05-08 2008-04-22 Lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire Ceased WO2008139855A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007123446 2007-05-08
JP2007-123446 2007-05-08

Publications (1)

Publication Number Publication Date
WO2008139855A1 true WO2008139855A1 (fr) 2008-11-20

Family

ID=40002072

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/057773 Ceased WO2008139855A1 (fr) 2007-05-08 2008-04-22 Lipide portant des dendrimères polyamidoamine contenant un groupe acyle de faible poids moléculaire

Country Status (2)

Country Link
JP (1) JP5446119B2 (fr)
WO (1) WO2008139855A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2428566A4 (fr) * 2009-05-07 2012-12-12 Public University Corp Osaka Prefecture University Composition d'agent de transfert de gène contenant un dendrimère de polyamidoamine
WO2013172358A1 (fr) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 Composé fonctionnel, assemblage moléculaire contenant un composé fonctionnel, composition contenant un assemblage moléculaire, trousse et utilisation de l'assemblage moléculaire, de la composition ou du trousse

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2691443B1 (fr) 2011-03-28 2021-02-17 Massachusetts Institute of Technology Lipomères conjugués et utilisations associées
MX363734B (es) * 2011-10-27 2019-03-29 Massachusetts Inst Technology Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505899A (ja) * 1993-01-22 1996-06-25 ザ・ダウ・ケミカル・カンパニー 吸収材、ゲルおよび金属イオン担体として用いる構造化コポリマー類
JP2004159504A (ja) * 2002-11-08 2004-06-10 Kansai Tlo Kk ポリアミドアミンデンドロンを含む遺伝子導入剤組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08505899A (ja) * 1993-01-22 1996-06-25 ザ・ダウ・ケミカル・カンパニー 吸収材、ゲルおよび金属イオン担体として用いる構造化コポリマー類
JP2004159504A (ja) * 2002-11-08 2004-06-10 Kansai Tlo Kk ポリアミドアミンデンドロンを含む遺伝子導入剤組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
TOSHINARI TAKAHASHI ET AL.: "Preparation of Efficient Gene Carriers Using a Polyamidoamine Dendron-Bearing Lipid: Improvement of Serum Resistance", BIOCONJUGATE CHEMISTRY, vol. 16, 27 August 2005 (2005-08-27), pages 1160 - 1165 *
TOSHINARI TAKAHASHI ET AL.: "Synthesis of Novel Cationic Lipids Having Polyamidoamine Dendrons and Their Transfection Activity", BIOCONJUGATE CHEMISTRY, vol. 14, 22 May 2003 (2003-05-22), pages 764 - 773, XP001170956, DOI: doi:10.1021/bc025663f *
YASUHIRO HABA ET AL.: "Control of Temperature-Sensitive Properties of Poly(amidoamine) Dendrimers Using peripheral Modification with Various Alkylamide Groups", MACROMOLECULES, vol. 39, 7 September 2006 (2006-09-07), pages 7451 - 7453 *
YASUHIRO HABA ET AL.: "Rendering Poly(amidoamine) or Poly(propyleneimine) Dendrimers Temperature Sensitive", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, 15 September 2004 (2004-09-15), pages 12760 - 12761 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2428566A4 (fr) * 2009-05-07 2012-12-12 Public University Corp Osaka Prefecture University Composition d'agent de transfert de gène contenant un dendrimère de polyamidoamine
US8557875B2 (en) 2009-05-07 2013-10-15 Public University Corporation Osaka Prefecture University Gene transfer agent composition containing polyamidoamine dendron
WO2013172358A1 (fr) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 Composé fonctionnel, assemblage moléculaire contenant un composé fonctionnel, composition contenant un assemblage moléculaire, trousse et utilisation de l'assemblage moléculaire, de la composition ou du trousse

Also Published As

Publication number Publication date
JP5446119B2 (ja) 2014-03-19
JP2008303210A (ja) 2008-12-18

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