[go: up one dir, main page]

WO2013188546A3 - Procédés pour la biosynthèse de 1,3-butadiène - Google Patents

Procédés pour la biosynthèse de 1,3-butadiène Download PDF

Info

Publication number
WO2013188546A3
WO2013188546A3 PCT/US2013/045430 US2013045430W WO2013188546A3 WO 2013188546 A3 WO2013188546 A3 WO 2013188546A3 US 2013045430 W US2013045430 W US 2013045430W WO 2013188546 A3 WO2013188546 A3 WO 2013188546A3
Authority
WO
WIPO (PCT)
Prior art keywords
butadiene
biosynthesizing
methods
pathways
dehydratases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/045430
Other languages
English (en)
Other versions
WO2013188546A2 (fr
Inventor
Paul S. Pearlman
Changlin Chen
Adriana BOTES
Alex van Eck CONRADIE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INVISTA TECHNOLOGIES SÀRL
Invista Technologies SARL USA
Original Assignee
INVISTA TECHNOLOGIES SÀRL
Invista Technologies SARL USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/042757 external-priority patent/WO2012174439A2/fr
Priority claimed from PCT/US2012/067463 external-priority patent/WO2013082542A2/fr
Application filed by INVISTA TECHNOLOGIES SÀRL, Invista Technologies SARL USA filed Critical INVISTA TECHNOLOGIES SÀRL
Priority to IN309DEN2015 priority Critical patent/IN2015DN00309A/en
Priority to EP13739305.4A priority patent/EP2861745A2/fr
Priority to JP2015517396A priority patent/JP2015519083A/ja
Priority to CN201380043586.3A priority patent/CN104769119A/zh
Publication of WO2013188546A2 publication Critical patent/WO2013188546A2/fr
Publication of WO2013188546A3 publication Critical patent/WO2013188546A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01127—Linalool dehydratase (4.2.1.127)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des voies biochimiques de fabrication de butadiène par la formation de deux groupes vinyle dans un substrat de synthèse de butadiène. Ces voies selon l'invention reposent sur des enzymes telles que la mévalonate diphosphate décarboxylase, l'isoprène synthase et les déshydratases pour l'étape enzymatique finale.
PCT/US2013/045430 2011-06-17 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène Ceased WO2013188546A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IN309DEN2015 IN2015DN00309A (fr) 2011-06-17 2013-06-12
EP13739305.4A EP2861745A2 (fr) 2012-06-15 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène
JP2015517396A JP2015519083A (ja) 2012-06-15 2013-06-12 １，３−ブタジエンを生合成するための方法
CN201380043586.3A CN104769119A (zh) 2012-06-15 2013-06-12 生物合成1,3丁二烯的方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US2012/042757 2012-06-15
PCT/US2012/042757 WO2012174439A2 (fr) 2011-06-17 2012-06-15 Procédés d'obtention de molécules à quatre carbones
USPCT/US2012/067463 2012-11-30
PCT/US2012/067463 WO2013082542A2 (fr) 2011-12-02 2012-11-30 Procédés de biosynthèse du 1,3-butadiène

Publications (2)

Publication Number Publication Date
WO2013188546A2 WO2013188546A2 (fr) 2013-12-19
WO2013188546A3 true WO2013188546A3 (fr) 2014-03-27

Family

ID=48803595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/045430 Ceased WO2013188546A2 (fr) 2011-06-17 2013-06-12 Procédés pour la biosynthèse de 1,3-butadiène

Country Status (3)

Country Link
EP (1) EP2861745A2 (fr)
CN (1) CN104769119A (fr)
WO (1) WO2013188546A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9777295B2 (en) 2012-11-28 2017-10-03 Invista North America S.A.R.L. Methods for biosynthesis of isobutene
US10533193B2 (en) 2013-08-05 2020-01-14 Invista North America S.A.R.L. Methods for biosynthesis of isobutene

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107254492A (zh) 2011-06-17 2017-10-17 英威达技术有限责任公司 产生1,3‑丁二烯的方法
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN104321434A (zh) * 2011-12-02 2015-01-28 英威达技术有限责任公司 生物合成1,3丁二烯的方法
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN105683385A (zh) 2013-08-05 2016-06-15 英威达技术有限责任公司 用于生物合成异戊二烯的方法
US20170152531A1 (en) 2014-06-16 2017-06-01 North America S.A.R.L. Process for producing glutarate and glutaric acid methyl ester
CN107075464A (zh) * 2014-09-03 2017-08-18 环球生物能源公司 从乙酰‑coa产生烯烃的重组微生物
US20160201097A1 (en) * 2014-12-22 2016-07-14 Invista North America S.á.r.l. Materials and Methods of Producing 7-Carbon Monomers
CN107849101A (zh) * 2015-02-27 2018-03-27 英威达技术有限责任公司 新的多肽及其用途
US9220742B1 (en) 2015-02-27 2015-12-29 Invista North America S.A.R.L. Mutant polypeptides and uses thereof
KR20170134682A (ko) 2015-04-09 2017-12-06 게노마티카 인코포레이티드 향상된 크로틸 알코올 생성을 위한 유전자조작 미생물 및 방법
CA2985231A1 (fr) * 2015-06-04 2016-12-08 Bioamber Inc. Production d'origine biologique d'acrylates et de dicarboxylates en c4 alpha-substitues fonctionnalises
WO2017006183A1 (fr) * 2015-07-08 2017-01-12 Conradie Alex Van Eck Procédés et cellules hôtes pour améliorer la production de 1,3-butanediol
EP3333263B1 (fr) * 2015-08-03 2021-12-29 Riken Variant de diphosphomévalonate décarboxylase et procédé de fabrication d'un composé oléfinique l'utilisant
CA2996728A1 (fr) * 2015-08-28 2017-03-09 Universitaet Des Saarlandes Moyens et procedes pour la production de composes organiques
WO2017068385A1 (fr) * 2015-10-23 2017-04-27 Metabolic Explorer Micro-organisme modifié pour l'assimilation d'acide lévulinique
CN105237420B (zh) * 2015-11-06 2017-09-12 安徽赛诺制药有限公司 L‑苏氨酸合成工艺
WO2018013701A1 (fr) 2016-07-12 2018-01-18 Braskem S.A. Formation d'alcènes par déshydratation enzymatique d'alcanols
WO2019006257A1 (fr) 2017-06-30 2019-01-03 Invista North America .S.A.R.L. Procédés, hôtes synthétiques et réactifs pour la biosynthèse d'hydrocarbures
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN110241103B (zh) * 2019-07-04 2021-01-19 江西邦泰绿色生物合成生态产业园发展有限公司 一种生物酶法生产异戊二烯的方法
CN111334514B (zh) * 2020-02-26 2021-06-22 广西大学 应用花生AhGSNOR基因提高植物耐铝性的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (fr) * 2008-06-17 2009-12-23 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de fumarate, malate, et acrylate
WO2011140171A2 (fr) * 2010-05-05 2011-11-10 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de butadiène
US20120021478A1 (en) * 2010-07-26 2012-01-26 Osterhout Robin E Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
WO2013082542A2 (fr) * 2011-12-02 2013-06-06 Invista North America S.A.R.L. Procédés de biosynthèse du 1,3-butadiène

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703455B2 (en) * 2012-08-29 2014-04-22 Scientist of Fourtune, S.A. Production of volatile dienes by enzymatic dehydration of light alkenols

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (fr) * 2008-06-17 2009-12-23 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de fumarate, malate, et acrylate
WO2011140171A2 (fr) * 2010-05-05 2011-11-10 Genomatica, Inc. Micro-organismes et procédés pour la biosynthèse de butadiène
US20110300597A1 (en) * 2010-05-05 2011-12-08 Burk Mark J Microorganisms and methods for the biosynthesis of butadiene
US20120021478A1 (en) * 2010-07-26 2012-01-26 Osterhout Robin E Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
WO2013082542A2 (fr) * 2011-12-02 2013-06-06 Invista North America S.A.R.L. Procédés de biosynthèse du 1,3-butadiène

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2861745A2 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9777295B2 (en) 2012-11-28 2017-10-03 Invista North America S.A.R.L. Methods for biosynthesis of isobutene
US10533193B2 (en) 2013-08-05 2020-01-14 Invista North America S.A.R.L. Methods for biosynthesis of isobutene

Also Published As

Publication number Publication date
EP2861745A2 (fr) 2015-04-22
WO2013188546A2 (fr) 2013-12-19
CN104769119A (zh) 2015-07-08

Similar Documents

Publication Publication Date Title
WO2013188546A3 (fr) Procédés pour la biosynthèse de 1,3-butadiène
WO2013082542A3 (fr) Procédés de biosynthèse du 1,3-butadiène
IN2015DN00309A (fr)
WO2012058494A3 (fr) Variantes d'isoprène synthase pour l'augmentation de la production d'isoprène
HK1215053A1 (zh) 用作生物合成罗汉果化合物的方法及材料
WO2015021045A3 (fr) Méthodes de biosynthèse d'isoprène
AU2012353654A8 (en) Modified microorganisms and methods of making butadiene using same
HK1201071A1 (en) Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
WO2010127304A3 (fr) Procédés de séquençage
WO2008142318A3 (fr) Genes codant pour la z,z-farnesyl diphosphate synthase et une sesquiterpene synthase a produits multiples et leurs utilisations
GB0906322D0 (en) Immobilized product tolerant microorganisms
WO2010014632A3 (fr) Procédés et compositions permettant d'améliorer la production de certains produits dans des micro-organismes
WO2008153712A3 (fr) Procede d'introduction d'acides nucleiques dans des cellules fongiques
WO2010014631A3 (fr) Procédés et compositions permettant d'améliorer la production de certains produits dans des micro-organismes
MY157798A (en) Ethanol production in non-recombination hosts
WO2008063849A3 (fr) Thérapie de la sclérose en plaque
WO2012050931A3 (fr) Production d'alpha-oléfines en utilisant des polycétides synthases
WO2011074954A3 (fr) Valencène synthase
WO2009075554A3 (fr) Procédé et système permettant de fournir des informations sur les brevets
WO2010015657A3 (fr) Nouveaux alcoxypyrazoles
EP3272860A4 (fr) Mutant de pyruvate déshydrogénase, micro-organisme le comprenant, et procédé de production d'acide l-aminé faisant appel audit micro-organisme
WO2010093182A3 (fr) Microorganisme permettant de produire des l-acides aminés et procédé de production de l-acides aminés l'utilisant
WO2015004211A3 (fr) Variantes de mévalonate diphosphate décarboxylase
WO2016175901A3 (fr) Matériels et méthodes de production de synthase de monomères à 6 carbones
WO2012021678A3 (fr) Bactéries isolées, procédés d'utilisation et procédés d'isolement

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13739305

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2015517396

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: IDP00201500187

Country of ref document: ID

Ref document number: 2013739305

Country of ref document: EP

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112014031349

Country of ref document: BR

REG Reference to national code

Ref country code: BR

Ref legal event code: B01E

Ref document number: 112014031349

Country of ref document: BR

ENPW Started to enter national phase and was withdrawn or failed for other reasons

Ref document number: 112014031349

Country of ref document: BR