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WO2008126104A3 - Novel process for preparation of adapalene - Google Patents

Novel process for preparation of adapalene Download PDF

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Publication number
WO2008126104A3
WO2008126104A3 PCT/IN2008/000236 IN2008000236W WO2008126104A3 WO 2008126104 A3 WO2008126104 A3 WO 2008126104A3 IN 2008000236 W IN2008000236 W IN 2008000236W WO 2008126104 A3 WO2008126104 A3 WO 2008126104A3
Authority
WO
WIPO (PCT)
Prior art keywords
adapalene
preparation
novel process
adamantyl
employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000236
Other languages
French (fr)
Other versions
WO2008126104A2 (en
Inventor
Ketan Dhansukhlal Vyas
Ranjeet Nair
Pravin Nalawade
Ulhas Digambar Patil
Aditi Milind Panandikar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indoco Remedies Ltd
Original Assignee
Indoco Remedies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indoco Remedies Ltd filed Critical Indoco Remedies Ltd
Publication of WO2008126104A2 publication Critical patent/WO2008126104A2/en
Publication of WO2008126104A3 publication Critical patent/WO2008126104A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Disclosed herein is a process for the preparation of the adamantyl derivative 6-[3-(l- Adamantyl) - 4 - methoxy phenyl] - 2 - naphthoic acid known as adapalene employing a novel intermediate 3 - Adamantyl - 4 - methoxyphenyl potassium trifluoroborate.
PCT/IN2008/000236 2007-04-11 2008-04-09 Novel process for preparation of adapalene Ceased WO2008126104A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN720/MUM/2007 2007-04-11
IN720MU2007 2007-04-11

Publications (2)

Publication Number Publication Date
WO2008126104A2 WO2008126104A2 (en) 2008-10-23
WO2008126104A3 true WO2008126104A3 (en) 2009-07-30

Family

ID=39864464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000236 Ceased WO2008126104A2 (en) 2007-04-11 2008-04-09 Novel process for preparation of adapalene

Country Status (1)

Country Link
WO (1) WO2008126104A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112724011B (en) * 2019-10-28 2024-04-05 广东东阳光药业股份有限公司 A method for refining adapalene
CN112479867B (en) * 2020-12-30 2024-03-29 武汉诺安药业有限公司 Chemical preparation method for micronization of adapalene

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1696100A (en) * 2005-06-01 2005-11-16 吴光彦 Now short cutting method for synthcsizing Adpalin dryg trcatubg acnc
WO2006108717A2 (en) * 2005-04-08 2006-10-19 Galderma Research & Development New method for the preparation of 6-(3-(1-adamantyl)-4-methoxphenyl)-2-naphthoic acid
CN1872829A (en) * 2006-04-18 2006-12-06 江苏中丹化工集团公司 Method for preparing Adapalene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108717A2 (en) * 2005-04-08 2006-10-19 Galderma Research & Development New method for the preparation of 6-(3-(1-adamantyl)-4-methoxphenyl)-2-naphthoic acid
CN1696100A (en) * 2005-06-01 2005-11-16 吴光彦 Now short cutting method for synthcsizing Adpalin dryg trcatubg acnc
CN1872829A (en) * 2006-04-18 2006-12-06 江苏中丹化工集团公司 Method for preparing Adapalene

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CASREACT [online] STN; MOLANDER, GARY A. ET AL.: "Efficient Ligandless Palladium-Catalyzed Suzuki Reactions of Potassium Aryltrifluorobora", Database accession no. 137:46793 *
DATABASE CASREACT [online] STN; VEDEJS, E. ET AL.: "Conversion of Arylboronic Acids into Potassium Aryltrifluoroborates: Convenient Precursors of Arylboron Difluoride Lewis Acids", Database accession no. 123:143956 *
JOURNAL OF ORGANIC CHEMISTRY, vol. 60, no. 10, 1995, pages 3020 - 3027 *
ORGANIC LETTERS, vol. 4, no. 11, 2002, pages 1867 - 1870 *

Also Published As

Publication number Publication date
WO2008126104A2 (en) 2008-10-23

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