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WO2011095990A3 - Process for the purification of prostaglandins and analogues thereof - Google Patents

Process for the purification of prostaglandins and analogues thereof Download PDF

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Publication number
WO2011095990A3
WO2011095990A3 PCT/IN2011/000076 IN2011000076W WO2011095990A3 WO 2011095990 A3 WO2011095990 A3 WO 2011095990A3 IN 2011000076 W IN2011000076 W IN 2011000076W WO 2011095990 A3 WO2011095990 A3 WO 2011095990A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostaglandins
analogues
purification
formula
prostaglandin derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2011/000076
Other languages
French (fr)
Other versions
WO2011095990A2 (en
Inventor
Mohan Anand Chandavarkar
Ramakrishnan Ramachandran Iyer
Vikas Vasant Nawathye
Gajanan Jalindar Chavan
Sandeep Laxman Nawale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHACHAD KALPESH CHINTAMANI
FDC Ltd
Original Assignee
CHACHAD KALPESH CHINTAMANI
FDC Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHACHAD KALPESH CHINTAMANI, FDC Ltd filed Critical CHACHAD KALPESH CHINTAMANI
Publication of WO2011095990A2 publication Critical patent/WO2011095990A2/en
Publication of WO2011095990A3 publication Critical patent/WO2011095990A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses a process for purification of prostaglandins of formula (1) into enantiomerically pure isomer of formula (2) by reverse phase preparative HPLC, and converting said isomer into prostaglandin derivative of formula (3). The prostaglandin derivative in this invention relates to PGF2α analogues
PCT/IN2011/000076 2010-02-03 2011-02-02 Process for the purification of prostaglandins and analogues thereof Ceased WO2011095990A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN283/MUM/2010 2010-02-03
IN283MU2010 2010-02-03

Publications (2)

Publication Number Publication Date
WO2011095990A2 WO2011095990A2 (en) 2011-08-11
WO2011095990A3 true WO2011095990A3 (en) 2012-01-12

Family

ID=44247901

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000076 Ceased WO2011095990A2 (en) 2010-02-03 2011-02-02 Process for the purification of prostaglandins and analogues thereof

Country Status (1)

Country Link
WO (1) WO2011095990A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103543216A (en) * 2012-07-17 2014-01-29 上海信谊药厂有限公司 Method for determining impurities in latanoprost eye drops
TWI435752B (en) * 2012-08-15 2014-05-01 Everlight Chem Ind Corp Method of purification of prostaglandins including fluorine atoms by preparative hplc
CN104297352B (en) * 2013-07-16 2017-11-07 天津金耀集团有限公司 A kind of travoprost content and the analysis method about material
US9115109B2 (en) * 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
HU231214B1 (en) 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. New process for preparing high purity prostaglandins
CN112209863A (en) * 2020-07-07 2021-01-12 浙江尖峰药业有限公司 Large-scale preparation method of tafluprost
EP4261206B1 (en) * 2020-12-23 2025-08-27 Kyowa Pharma Chemical Co., Ltd. Method for separating geometrical isomer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155973A1 (en) * 2005-12-30 2007-07-05 Everlight Usa, Inc. Novel intermediate compound for the preparation of prostaglandin F analogue
WO2008081191A1 (en) * 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962312A (en) 1972-09-21 1976-06-08 Ono Pharmaceutical Company 9,11,15-Trihydroxy prost-5-enoic acid analogues
EP0569046B1 (en) 1988-09-06 2002-11-13 Pharmacia Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US7166730B2 (en) 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
JP2004535465A (en) 2001-07-17 2004-11-25 ファルマシア・アンド・アップジョン・カンパニー Latanoprost synthesis method and intermediate
PL212658B1 (en) 2005-04-18 2012-11-30 Inst Farmaceutyczny Method for obtaining the derivatives of 13,14-dihydro-PGF₂α

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155973A1 (en) * 2005-12-30 2007-07-05 Everlight Usa, Inc. Novel intermediate compound for the preparation of prostaglandin F analogue
WO2008081191A1 (en) * 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUZZETTA ANDREW: "Reverse Phase HPLC Basics for LC/MS", INTERNET CITATION, 22 July 2001 (2001-07-22), pages 1 - 9, XP002556091, Retrieved from the Internet <URL:http://ionsource.com/tutorial/chromatography/rphplc.htm> [retrieved on 20091118] *

Also Published As

Publication number Publication date
WO2011095990A2 (en) 2011-08-11

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