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WO2008120766A1 - Analgesic composition - Google Patents

Analgesic composition Download PDF

Info

Publication number
WO2008120766A1
WO2008120766A1 PCT/JP2008/056240 JP2008056240W WO2008120766A1 WO 2008120766 A1 WO2008120766 A1 WO 2008120766A1 JP 2008056240 W JP2008056240 W JP 2008056240W WO 2008120766 A1 WO2008120766 A1 WO 2008120766A1
Authority
WO
WIPO (PCT)
Prior art keywords
analgesic
analgesic composition
composition
agent
compared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056240
Other languages
French (fr)
Japanese (ja)
Inventor
Manabu Nozaki
Shigeki Sawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Kobayashi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co Ltd filed Critical Kobayashi Pharmaceutical Co Ltd
Publication of WO2008120766A1 publication Critical patent/WO2008120766A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

[PROBLEMS] To provide an analgesic composition which is more safe compared to a conventional analgesic agent and exhibits an analgesic activity at the same or higher level compared to a conventional analgesic agent. [MEANS FOR SOLVING PROBLEMS] Disclosed is an analgesic composition comprising vitamin B12 as an active ingredient. Preferably, the analgesic composition additionally contains folic acid.
PCT/JP2008/056240 2007-03-30 2008-03-28 Analgesic composition Ceased WO2008120766A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-091794 2007-03-30
JP2007091794A JP5241127B2 (en) 2007-03-30 2007-03-30 Analgesic composition

Publications (1)

Publication Number Publication Date
WO2008120766A1 true WO2008120766A1 (en) 2008-10-09

Family

ID=39808346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056240 Ceased WO2008120766A1 (en) 2007-03-30 2008-03-28 Analgesic composition

Country Status (2)

Country Link
JP (1) JP5241127B2 (en)
WO (1) WO2008120766A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7026457B2 (en) * 2016-07-07 2022-02-28 第一三共ヘルスケア株式会社 Oral pharmaceutical composition containing loxoprofen or a salt thereof and vitamins B12
JP7499027B2 (en) * 2019-12-27 2024-06-13 小林製薬株式会社 Internal pharmaceutical composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050028A1 (en) * 1999-02-24 2000-08-31 Andrew Peter Worsley Compositions for the treatment of pain
WO2000056404A1 (en) * 1999-03-24 2000-09-28 Kilgowan Limited Formulations for treatment of pain comprising vitamin b12 and phenylanine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050028A1 (en) * 1999-02-24 2000-08-31 Andrew Peter Worsley Compositions for the treatment of pain
WO2000056404A1 (en) * 1999-03-24 2000-09-28 Kilgowan Limited Formulations for treatment of pain comprising vitamin b12 and phenylanine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRUGGEMANN G. ET AL.: "Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae", KLIN. WOCHENSCHR., vol. 68, no. 2, 1990, pages 116 - 120 *
GLUECK C.J. ET AL.: "Stromelysin-1 5A/6A and eNOS T-768C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease", CLIN. APPL. THROMB. HEMOST., vol. 12, no. 4, 2006, pages 427 - 439 *
O'SHAUGHNESSY J.A. ET AL.: "Phase II study of pemetrexed in patients pretreated with an anthracycline, a taxane, and capecitabine for advanced breast cancer", CLIN. BREAST CANCER, vol. 6, no. 2, 2005, pages 143 - 149 *

Also Published As

Publication number Publication date
JP5241127B2 (en) 2013-07-17
JP2008247823A (en) 2008-10-16

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