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WO2008120070A3 - 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic action, a method for its production and a pharmaceutical composition based thereon - Google Patents

2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic action, a method for its production and a pharmaceutical composition based thereon Download PDF

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Publication number
WO2008120070A3
WO2008120070A3 PCT/IB2008/000727 IB2008000727W WO2008120070A3 WO 2008120070 A3 WO2008120070 A3 WO 2008120070A3 IB 2008000727 W IB2008000727 W IB 2008000727W WO 2008120070 A3 WO2008120070 A3 WO 2008120070A3
Authority
WO
WIPO (PCT)
Prior art keywords
thioctate
trimethylammonium
hydroxyethyl
hepatoprotective
choline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/000727
Other languages
French (fr)
Other versions
WO2008120070A2 (en
Inventor
Ivan Ivanovych Novik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU =GALYCHFARM=
TOVARYSTVO Z OBMEZHENOYU VIDPOVIDALNISTYU =INSTYTUT FITO-HIMICHNYH TEHNOLOGIJ=
VIDKRYTE AKTSIONERNE TOVARYSTVO =KYIVMEDPREPARAT=
AKTSIONERNE TOVARYSTVO VIDKRYT
TOVARYSTVO Z OBMEZHENOYU VIDPO
VIDKRYTE AKTSIONERNE TOVARYSTV
Original Assignee
AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU =GALYCHFARM=
TOVARYSTVO Z OBMEZHENOYU VIDPOVIDALNISTYU =INSTYTUT FITO-HIMICHNYH TEHNOLOGIJ=
VIDKRYTE AKTSIONERNE TOVARYSTVO =KYIVMEDPREPARAT=
AKTSIONERNE TOVARYSTVO VIDKRYT
TOVARYSTVO Z OBMEZHENOYU VIDPO
VIDKRYTE AKTSIONERNE TOVARYSTV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU =GALYCHFARM=, TOVARYSTVO Z OBMEZHENOYU VIDPOVIDALNISTYU =INSTYTUT FITO-HIMICHNYH TEHNOLOGIJ=, VIDKRYTE AKTSIONERNE TOVARYSTVO =KYIVMEDPREPARAT=, AKTSIONERNE TOVARYSTVO VIDKRYT, TOVARYSTVO Z OBMEZHENOYU VIDPO, VIDKRYTE AKTSIONERNE TOVARYSTV filed Critical AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU =GALYCHFARM=
Publication of WO2008120070A2 publication Critical patent/WO2008120070A2/en
Publication of WO2008120070A3 publication Critical patent/WO2008120070A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to medicine and chemical and pharmaceutical industry, and more particularly to a new physiologically active substance 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic activity, to a method for producing said substance, and to pharmaceutical compositions based thereon. The technical result of implementing the invention is a new physiologically active chemical substance 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic activity, a method for producing the same which method ensures a higher level and a wider spectrum of specific activity while simplifying, and shortening the duration of the manufacturing process, and pharmaceutical compositions based on the new physiologically active substance 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) in various dosage forms the use whereof results in a diversified range of hepatoprotective drugs.
PCT/IB2008/000727 2007-03-30 2008-03-17 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic action, a method for its production and a pharmaceutical composition based thereon Ceased WO2008120070A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
UAA200703481 2007-03-30
UAA200703481A UA86441C2 (en) 2007-03-30 2007-03-30 (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it

Publications (2)

Publication Number Publication Date
WO2008120070A2 WO2008120070A2 (en) 2008-10-09
WO2008120070A3 true WO2008120070A3 (en) 2008-12-31

Family

ID=39808755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/000727 Ceased WO2008120070A2 (en) 2007-03-30 2008-03-17 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic action, a method for its production and a pharmaceutical composition based thereon

Country Status (2)

Country Link
UA (1) UA86441C2 (en)
WO (1) WO2008120070A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US7914815B2 (en) 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US8147816B2 (en) 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
US8697109B2 (en) 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US8647612B2 (en) 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
US9044439B2 (en) 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
EP2821405B1 (en) 2009-06-15 2016-04-13 Encore Health, LLC Choline esters for treating presbyopia and cataract
WO2010147957A2 (en) 2009-06-15 2010-12-23 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
BR112016020181A8 (en) 2014-03-03 2021-06-29 Encore Vision Inc choline ester lipoic acid compositions and methods of use.
MX2020008173A (en) * 2018-02-05 2020-09-25 Cellix Bio Private Ltd Combination of an antimuscarinic or an anticholinergic agent and lipoic acid and uses thereof.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1077039A (en) * 1965-10-21 1967-07-26 Henry Eugene Jean Marie Meunie A choline derivative and therapeutic compositions containing it
WO1999055331A1 (en) * 1998-04-25 1999-11-04 Skw Trostberg Aktiengesellschaft Use of alpha lipoic acid to reduce appetite and/or body weight

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1077039A (en) * 1965-10-21 1967-07-26 Henry Eugene Jean Marie Meunie A choline derivative and therapeutic compositions containing it
WO1999055331A1 (en) * 1998-04-25 1999-11-04 Skw Trostberg Aktiengesellschaft Use of alpha lipoic acid to reduce appetite and/or body weight

Also Published As

Publication number Publication date
UA86441C2 (en) 2009-04-27
WO2008120070A2 (en) 2008-10-09

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