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WO2008117899A1 - Dispositif d'hémofiltration de type coulissant - Google Patents

Dispositif d'hémofiltration de type coulissant Download PDF

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Publication number
WO2008117899A1
WO2008117899A1 PCT/KR2007/001460 KR2007001460W WO2008117899A1 WO 2008117899 A1 WO2008117899 A1 WO 2008117899A1 KR 2007001460 W KR2007001460 W KR 2007001460W WO 2008117899 A1 WO2008117899 A1 WO 2008117899A1
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WO
WIPO (PCT)
Prior art keywords
blood
hemofiltration
excretion
bag
replacement fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2007/001460
Other languages
English (en)
Inventor
Jong-Weon Choi
Byoung-Goo Min
Jung-Chan Lee
Ki-Ho Yoon
Seung-Min Lee
Dae-Seok Choi
Seong-Wook Choi
Woo-Hyun Kang
Jeong-Chul Kim
Kyoung-Kap Lee
Ji-Hyun Kim
Young-Min Yun
Yong-Soon Won
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BHK
Original Assignee
BHK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BHK filed Critical BHK
Publication of WO2008117899A1 publication Critical patent/WO2008117899A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3401—Cassettes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362262—Details of incorporated reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362263—Details of incorporated filters
    • A61M1/362264—Details of incorporated filters the filter being a blood filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222—Details related to the interface between cassette and machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36224—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with sensing means or components thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A61M2205/126—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters with incorporated membrane filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/15—Detection of leaks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback

Definitions

  • the present invention relates to a slide type hemofiltration device, and more particularly, to a hemofiltration device, with which a patient can observe the process of blood filtration, and a slide cover, with an operation panel and a display mounted thereon, configured to slide to open/close the device.
  • Kidney transplantation or renal transplantation is a method of transplanting a diseased kidney of a patient with a donor's kidney, which completely replaces the function of the patient's kidney.
  • the number of donors is much smaller than that needed, and even when transplantation is carried out, side effects such as rejection may occur. Accordingly, the majority of chronic renal failure patients are treated using renal replacement therapy.
  • Renal replacement therapy is generally divided into hemodialysis, hemofiltration and peritoneal dialysis.
  • Hemodialysis is a method of using a counter current flow between blood and clean dialysate across a semi-permeable membrane, and can remove waste products from the blood by diffusing the waste products into the dialysate when kidneys are incapable of doing so.
  • Hemofiltration is a method of removing waste products from the blood when excretion passes through a semipermeable membrane by ultra- filtration due to hydrostatic pressure of the blood, and adds replacement fluid to the filtered blood before it is returned to the patient.
  • Peritoneal dialysis is a method of instilling dialysate into the abdominal cavity so that waste products diffuse to the dialysate from the blood in capillary vessels of the peritoneal membrane.
  • a hemodialysis device for hemodialysis includes a water purifier, supplying a large amount of purified water, a dialysate-forming unit including a pump, a heat exchanger and a dialysate concentration sensor to convert the purified water into dialysate, a pump regulating the amount of blood and the dialysate, a blood pressure sensor measuring the blood pressure in a blood line, a blood leakage sensor detecting blood leakage, a bubble sensor detecting bubbles in the blood line, a tube clamp interrupting the flow of blood in the blood line, a syringe pump injecting anticoagulant, and etc.
  • Hemodialysis is known as the most efficient of several renal replacement therapies.
  • a hemofiltration device includes a pump, which regulates the quantity of blood, replacement fluid and excretion, a blood pressure sensor, a blood leakage sensor, a bubble sensor, a tube clamp, a syringe pump, balances measuring replacement liquid and excretion, etc.
  • Hemofiltration can remove waste products having high molecular weight better than hemodialysis. Since this method does not require large water purifying equipment, treatment can be enabled even if only a small quantity of replacement fluid is prepared in a sterilized package. Furthermore, the hemofiltration device is smaller and simpler than the hemodialysis device, and thus can be advantageously utilized for home care therapy.
  • This type of hemofiltration device can be embodied as various constructions and structures.
  • FIG. 1 is a front perspective view of a conventional hemofiltration device
  • FIGS. 2 to 4 are stepwise side elevation views illustrating a process of mounting a hemofiltration cartridge in the conventional hemofiltration device.
  • the hemofiltration device shown in FIGS. 1 to 4 is a hemofiltration machine
  • the hemofiltration machine includes a machine body 10, in which a driving source for blood filtration and sensors are fitted, and a cover 20 coupled to one face of the body 10 to open or close the face.
  • a hemofiltration cartridge 30, in which filters, chambers and tubes used in hemofiltration are fitted, is mounted between the machine body 10 and the cover 20.
  • the hemofiltration cartridge 30 is configured to filter blood from a patient, return the filtered blood to the patient by adding replacement fluid to the blood, and discharge excretion produced during hemofiltration.
  • the hemofiltration cartridge 30 is manufactured as a disposable part, which is discarded after carrying out blood filtration one time, and thus a new one is used for every hemofiltration session. As an advantageous effect, patients can undergo treatment using the hemofiltration device without the worry of infection.
  • the hemofiltration cartridge 30 is mounted according to the following process:
  • the hemofiltration cartridge 30 can be easily replaced by an average person who is not professional medical personnel, and thus the hemofiltration device can be advantageously used for home care.
  • the hemofiltration device cannot measure, in real time, the quantity of replacement fluid and excretion, so that adjustment of the quantity of fluid may cause a problem.
  • the status of blood flowing in blood lines cannot be observed from the outside. Since the hemofiltration cartridge 30 is completely inserted between the body 10 and the cover 20, a patient cannot observe whether or not blood, replacement fluid, excretion and so on are properly flowing. The patient cannot determine the status of these fluids by himself/herself, but must totally depend on sensors to determine the status. Accordingly, when any of the sensors is not properly operating, a severe problem can occur.
  • the present invention has been made to solve the foregoing problems with the prior art, and therefore the present invention is directed to a hemofiltration device, with which a patient can observe, with the naked eye, the status of blood during hemofiltration, and a sufficient area can be ensured to mount a hemofiltration cartridge, and which can be installed and used in a small area.
  • a hemofiltration device which includes a body having a driving unit, which supplies power necessary for blood filtration; a cover slidably coupled to a face of the body to open or close the face; and a hemofiltration cartridge having a blood filter and mounted on the face of the body, which is opened by a sliding movement of the cover.
  • the cover may have a vertically slidable structure, which is mounted on the front face of the body.
  • the cover may include an operation panel for operating the body and a display displaying the process of blood filtration.
  • the hemofiltration cartridge may include a mounting panel, which is mounted on the face of the body, and chambers and tubes, which are mounted on the mounting panel to guide the flow of blood, replacement fluid and excretion.
  • a mounting area may be provided between the face of the body and the hemofiltration cartridge, the chambers and the tubes may be disposed in the mounting area, and the mounting panel may be made of transparent material to expose the chambers and the tubes.
  • the hemofiltration cartridge may include a blood bag having an internal channel splitting into two branch channels, the blood bag may include inlet-side blood diaphragms at inlet sides of the branch channels and outlet- side blood diaphragms at outlet sides of the branch channels, and the driving unit may include a dual pulse blood pump applying alternating pressure to the two branch channels of the blood bag.
  • the body may include a replacement fluid bag hanger, on which a replacement fluid bag filled with replacement fluid is hung, and an excretion bag hanger, on which an excretion bag filled with excretion is hung, the replacement fluid bag hanger may be additionally provided with a replacement fluid balance to measure the weight of the replacement fluid bag, and the excretion bag hanger may be additionally provided with an excretion balance to measure the weight of the excretion bag.
  • the patient can observe, with the naked eye, the status of blood during hemofiltration, and sufficient area is ensured for the mounting of a hemofiltration cartridge. Furthermore, the hemofiltration device can be installed and used even in a small area.
  • FIG. 1 is a front perspective view of a conventional hemofiltration device
  • FIGS. 2 to 4 are stepwise side elevation views illustrating a process of mounting a hemofiltration cartridge in the conventional hemofiltration device
  • FIG. 5 is a front perspective view of a hemofiltration device according to the present invention.
  • FIG. 6 is a front elevation view of the body and the cover of the hemofiltration device according to the present invention.
  • FIG. 7 is a front perspective view of the hemofiltration device according to the present invention, in which the cover is closed.
  • FIG. 8 is an exploded perspective view of the hemofiltration device according to the present invention.
  • FIG. 5 is a front perspective view of a hemofiltration device according to the present invention
  • FIG. 6 is a front elevation view of the body and the cover of the hemofiltration device according to the present invention.
  • the hemofiltration device of the present invention is configured to filter blood from a patient, thereby discharging excretion during blood filtration, and dilute the filtered blood with replacement fluid before returning the blood to the patient.
  • the hemofiltration device of the present invention includes a device body 100, a cover 200 and a hemofiltration cartridge 300.
  • the device body 100 supplies power necessary for blood filtration, and measures the hydrostatic pressure and status of blood, excretion and replacement fluid.
  • the cover 200 is configured to slide along and couple to one face of the body 100, thereby opening/closing the face.
  • the hemofiltration cartridge 300 is mounted on the face of the body 100, which is opened or closed through the sliding of the cover 200, and has a blood filter 350 to remove impurities and waste products from the blood.
  • the body 100 has a recessed mounting area 106 (i.e., the front area in this embodiment), on which the cartridge 300 is mounted.
  • the body 100 also includes, in the mounting area 106, a driving unit 110, supplying power necessary for blood filtration, and a sensor unit 120 measuring the hydrostatic pressure and status of blood, excretion and replacement fluid and other components used for blood filtration (see FIG. 8).
  • a driving unit 110 supplying power necessary for blood filtration
  • a sensor unit 120 measuring the hydrostatic pressure and status of blood, excretion and replacement fluid and other components used for blood filtration.
  • the replacement fluid bag hanger 102 is additionally provided with a replacement fluid balance (not shown) to measure the weight of the replacement fluid bag 400 in order to determine, in real time, the amount of replacement fluid, which dilutes blood.
  • the excretion bag hanger 104 is additionally provided with an excretion balance (not shown) to measure the weight of the excretion bag 500 in order to determine, in real time, the amount of excretion, which is collected in the excretion bag 500.
  • the replacement fluid balance and the excretion balance may include a weight detecting device, such as a load cell, which can convert weight into a digital signal.
  • the cover 200 is slidably coupled to one face of the body 100 to open/close the mounting area of the hemofiltration cartridge 300, and is provided, on the outer face thereof, with an operation panel 210, which is used to operate respective components, and a display 220, which outputs various data related to blood filtration.
  • the cover 200 does not protrude forwards, but slides upwards and downwards along one side of the body 100, as shown in FIG. 5.
  • the hemofiltration device of the present invention can be easily used in a small mounting area.
  • the cover 200 is configured to slide upwards to open one face of the body 100, on which the cartridge 300 is mounted.
  • the cover 200 can be configured to slide downwards to open the face of the body 100, on which the cartridge 300 is mounted.
  • the body 100 is supported on a stand 600 in this embodiment, the body 100 can also be seated on a floor or a table. Accordingly, it may be advantageous to open the face of the body 100, on which the cartridge 300 is mounted, by sliding the cover 200 upwards as shown in FIG. 5.
  • the hemofiltration cartridge 300 serves to filter blood from a patient and dilute fil tered blood with replacement fluid before returning the blood to the patient while discharging excretion produced during blood filtration.
  • the hemofiltration cartridge 300 is manufactured as a disposable part, which is discarded after blood filtration is performed once in order to prevent infection.
  • the hemofiltration cartridge 300 includes a mounting panel 310, which is mounted on one side of the body 100, and various chambers and tubes, which guide the flow of blood, replacement fluid and excretion.
  • the chambers and the tubes are coupled to the rear side of the mounting panel 310 so as to be located within the mounting area 106 of the body 100, and the mounting panel 310 is made of transparent material such as transparent plastic so that the patient can observe the flowing status of blood.
  • the patient can observe, with the naked eye, blood, replacement fluid, excretion and so on, which flow along the chambers and the tubes.
  • blood For example, it is possible to observe, with the naked eye, whether or not blood is normally flowing in and out, replacement fluid is being properly supplied, or excretion is being normally discharged. It is also possible to observe whether or not bubbles are present in the flow of blood or foreign materials have been introduced into the blood. Since the flow of blood, replacement fluid and excretion can be observed with the naked eye, it is possible to recognize whether or not blood, replacement fluid and excretion are properly flowing even if sensors are not properly operating. This as a result can prevent various accidents, which otherwise may occur during blood filtration.
  • the front side of the cover 200, on which the operation panel 210 and the display 220 are mounted is oriented in the same direction as the front side of the body 100, on which the hemofiltration cartridge 300 is mounted, so that the patient can observe various data on the display 220 and observe, with the naked eye, the flow of blood, replacement fluid, extract and so on while manipulating the operation panel 210.
  • the patient can be reassured since he/she can see various data on the display 220 and the flow of blood, replacement fluid, excretion and so on during blood filtration.
  • FIG. 7 is a front perspective view of the hemofiltration device according to the present invention, in which the cover is closed.
  • the cover 200 can slide downwards so that the rear side of the cover 200 overlaps the front side of the body 100, thereby preventing foreign materials from entering the mounting area of the hemofiltration cartridge 300 when the device is not used.
  • the cover 200 which slides downwards as above, can reduce the total volume of the hemofiltration device, thereby facilitating the carriage and storage of the device.
  • FIG. 8 is an exploded perspective view of the hemofiltration device according to the present invention.
  • the hemofiltration cartridge 300 includes an artery blood tube
  • the mounting panel 310 is provided with an artery blood port 311, a replacement fluid port 312, an excretion port 313 and a vein blood port 314, through which the tubes can pass.
  • the hemofiltration cartridge 300 also includes a blood bag 330, an artery blood drop chamber 340, a blood filter 350 and a vein blood drop chamber 360.
  • the blood bag 330 has an internal channel, which splits into two branch channels, and is provided, at inlet and outlet sides of the branch channels, with inlet- side blood diaphragms 331 and outlet-side blood diaphragms 332 to prevent backflow.
  • the artery blood drop chamber 340 receives blood through the blood bag 330 and stores a predetermined amount of the received blood.
  • the blood filter 350 filters the blood supplied through the artery blood drop chamber 340, and the vein blood drop chamber 360 receives the blood filtered by the blood filter 350.
  • various tubes and chambers including the blood bag 330 are illustrated as being separated from the mounting panel 310 in order to more clearly express the shape of the tubes and chambers including the blood bag 330.
  • the tubes and the chambers including the blood bag 330 are mounted to the rear side of the mounting panel 310 and used as disposable parts together with the mounting panel.
  • the driving unit 110 which supplies power necessary for blood filtration
  • the sensor unit 120 which measures the hydrostatic pressure and status of blood, excretion and replacement fluid, and other components, which are used for blood filtration.
  • the driving unit 110 includes a dual pulse blood pump 111, which applies alternating pressure to the two branch channels of the blood bag 330 to carry blood from the patient to the blood filter 350 as a pulsatile blood flow similar to an actual blood flow.
  • the driving unit 110 also includes a replacement fluid pump 112, which applies pressure to the replacement fluid bag 322 so that replacement fluid can be properly supplied, and an extract pump 113, which applies pressure to the extraction bag 322 so that extraction can be properly discharged.
  • the dual pulse blood pump 111 presses a first one of the branch channels of the blood bag 330
  • the pressure of blood in the first branch channel of the blood bag 330 increases.
  • the inlet-side blood diaphragm 331 and the outlet-side blood diaphragm 332 in the blood bag 330 allow blood to flow only in a forward direction but not in a reverse direction, so that blood in the first branch channel is supplied through the outlet-side blood diaphragm 332 to the artery blood drop chamber 340.
  • the use of the dual pulse blood pump 111 makes it possible to carry blood as a pulsatile blood flow similar to the actual flow of blood in the body, thereby advantageously improving the performance and the stability of the blood filter 350.
  • the dual pulse blood pump 111 is disclosed in some documents, such as Korean
  • Patent No. 0382887 titled “Dual Pulse Heart Lung Machine”
  • Korean Patent No. 0678512 titled “Dual Pulse Heart Lung Machine and Operating Method Thereof”
  • Korean Patent Publication No. 10-2004-0026193 titled “Hemodialysis Device Using Pulse Pump,” all of which were filed by the present applicant.
  • the sensor unit 120 includes a blood sensor 121 detecting the pressure of blood supplied through the artery blood tube 321, a pre-filter pressure sensor 122 detecting the pressure of blood within the artery blood drop chamber 340, a return pressure sensor 123 detecting the pressure of blood within the vein blood drop chamber 360, a bubble sensor 124 detecting the occurrence of bubbles in filtered blood before the blood is returned to the patient, a pressure sensor 125 measuring the pressure of excretion, which is discharged through the excretion tube 323, and an excretion sensor 126 detecting the presence of blood in the excretion.
  • the bubble sensor 124 When bubbles are present in the blood to be supplied to the patient, the bubble sensor 124 immediately interrupts the operation of the dual pulse blood pump 111 and closes the vein blood tube 324 using a tube clamp in the vein blood tube 324, so that bubbles do not enter the patient. The bubble sensor 124 also generates an alarm indicating that bubbles are formed in the blood.
  • the excretion sensor 126 When blood leakage into the excretion is detected, the excretion sensor 126 immediately interrupts the operation of the pump, closes the blood line using a tube clamp, and generates an alarm.
  • the sensor unit 120 may be configured to compare the amount of excretion and the amount of replacement fluid, which are actually measured by the balances, with a predetermined value of net ultra-filtration and a value calculated through treatment time, so that the amount of moisture inside the body can be constantly balanced.
  • the hemofiltration device of the present invention can also be provided with an anticoagulant injection part 130, which continuously injects anticoagulant into the blood bag 330 in order to prevent blood from coagulating in the artery blood tube 321, the vein blood tube 324 or the blood filter 350 during blood filtration.
  • the blood sensor 121 detects the flow rate and the pressure of the blood.
  • the blood flows to the blood bag 330, and is then carried to the artery drop chamber 340 by the dual pulse blood pump 111.
  • the pre-filter pressure sensor 122 detects the pressure of the blood carried into the artery blood drop chamber 340 in order to determine whether or not the blood pressure is in a normal range.
  • the blood After it is discharged from the artery blood drop chamber 240, the blood enters the blood filter 350, which discharges a portion of the excretion according to predetermined conditions but sends the remaining portion of the blood to the vein blood drop chamber 360.
  • replacement fluid is introduced from the replacement fluid bag 400 through the replacement fluid port 312 into the vein blood drop chamber 360, thereby mixing with the blood.
  • the blood passes through the bubble sensor 124, which detects bubbles in the blood, and finally through the tube clamp 140 before returning to the patient through the vein blood portion 314.
  • the excretion discharged from the blood filter 350 passes through the excretion sensor 126, which measures the pressure of the excretion, and is carried through the excretion port 313 by the excretion pump 113 to be collected in the excretion bag 500.
  • the hemofiltration cartridge 300 which filters blood using the blood filter 350 and adds replacement fluid to the filtered blood before returning it to the patient, has substantially the same construction and operation as the hemofiltration cartridge of the conventional hemofiltration device, and thus a detailed description thereof will be omitted.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un dispositif d'hémofiltration comportant un corps comprenant une unité de commande, qui fournit l'énergie nécessaire à la filtration sanguine ; un couvercle couplé en coulissement à une face du corps pour ouvrir et fermer la face ; et une cartouche d'hémofiltration comprenant un filtre sanguin et montée sur la face du corps, qui est ouverte par un mouvement du couvercle. Un patient peut observer, à l'œil nu, l'état du sang lors de l'hémofiltration, et une surface suffisante est prévue pour le montage de la cartouche d'hémofiltration. Le dispositif d'hémofiltration peut être installé et utilisé dans une zone restreinte.
PCT/KR2007/001460 2007-03-23 2007-03-26 Dispositif d'hémofiltration de type coulissant Ceased WO2008117899A1 (fr)

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KR10-2007-0028738 2007-03-23
KR1020070028738A KR100827496B1 (ko) 2007-03-23 2007-03-23 슬라이드형 혈액여과장치

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CN105413002A (zh) * 2014-09-17 2016-03-23 B·布莱恩·阿维图姆股份公司 透析机
IT202100000521A1 (it) * 2021-01-13 2022-07-13 Medica S P A Dispositivo per diuresi artificiale

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KR101039058B1 (ko) 2008-01-15 2011-06-07 최종원 혈액여과장치
KR102182592B1 (ko) * 2020-03-10 2020-11-24 이건형 실린더 펌프

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US5629871A (en) * 1995-06-07 1997-05-13 Cobe Laboratories, Inc. Wear trend analysis technique for components of a dialysis machine
US6890315B1 (en) * 2000-05-23 2005-05-10 Chf Solutions, Inc. Method and apparatus for vein fluid removal in heart failure
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CN105413002A (zh) * 2014-09-17 2016-03-23 B·布莱恩·阿维图姆股份公司 透析机
EP2997987A1 (fr) * 2014-09-17 2016-03-23 B. Braun Avitum AG Machine de dialyse
US9827360B2 (en) 2014-09-17 2017-11-28 B. Braun Avitum Ag Dialysis machine
IT202100000521A1 (it) * 2021-01-13 2022-07-13 Medica S P A Dispositivo per diuresi artificiale
WO2022153210A3 (fr) * 2021-01-13 2022-08-25 Medica S.P.A. Dispositif de diurèse artificielle

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