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WO2008117775A1 - オキセタン環構造を有するタキサン化合物 - Google Patents

オキセタン環構造を有するタキサン化合物 Download PDF

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Publication number
WO2008117775A1
WO2008117775A1 PCT/JP2008/055428 JP2008055428W WO2008117775A1 WO 2008117775 A1 WO2008117775 A1 WO 2008117775A1 JP 2008055428 W JP2008055428 W JP 2008055428W WO 2008117775 A1 WO2008117775 A1 WO 2008117775A1
Authority
WO
WIPO (PCT)
Prior art keywords
taxanes
ring structure
oxetane ring
cancer
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/055428
Other languages
English (en)
French (fr)
Inventor
Kouichi Uoto
Yasuyuki Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of WO2008117775A1 publication Critical patent/WO2008117775A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

高い抗腫瘍活性を有し、かつ、安全性の高い新規タキサン系抗癌剤を提供すること。 下記一般式（１）で表されるオキセタン環構造を有するタキサン化合物、ならびに、一般式（１）で表される化合物を含む医薬、一般式（１）で表される化合物を含む医薬組成物、および一般式（１）で表される化合物を用いる癌の治療方法等を提供する。
PCT/JP2008/055428 2007-03-27 2008-03-24 オキセタン環構造を有するタキサン化合物 Ceased WO2008117775A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-081742 2007-03-27
JP2007081742 2007-03-27

Publications (1)

Publication Number Publication Date
WO2008117775A1 true WO2008117775A1 (ja) 2008-10-02

Family

ID=39788510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055428 Ceased WO2008117775A1 (ja) 2007-03-27 2008-03-24 オキセタン環構造を有するタキサン化合物

Country Status (2)

Country Link
TW (1) TW200901967A (ja)
WO (1) WO2008117775A1 (ja)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07233159A (ja) * 1993-12-20 1995-09-05 Dai Ichi Seiyaku Co Ltd タキソール誘導体
JPH08503219A (ja) * 1992-11-13 1996-04-09 フロリダ・ステート・ユニバーシティー アルキル置換側鎖を有するタキサンおよびそれを含有する薬剤組成物
JPH0912578A (ja) * 1995-04-28 1997-01-14 Dai Ichi Seiyaku Co Ltd 五環性化合物
WO1999037631A1 (en) * 1998-01-26 1999-07-29 Hanmi Pharmaceutical Co., Ltd. Novel taxaneterpine compounds
WO2007049575A1 (ja) * 2005-10-25 2007-05-03 Daiichi Sankyo Company, Limited アゼチジン環構造を有するタキサン化合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503219A (ja) * 1992-11-13 1996-04-09 フロリダ・ステート・ユニバーシティー アルキル置換側鎖を有するタキサンおよびそれを含有する薬剤組成物
JPH07233159A (ja) * 1993-12-20 1995-09-05 Dai Ichi Seiyaku Co Ltd タキソール誘導体
JPH0912578A (ja) * 1995-04-28 1997-01-14 Dai Ichi Seiyaku Co Ltd 五環性化合物
WO1999037631A1 (en) * 1998-01-26 1999-07-29 Hanmi Pharmaceutical Co., Ltd. Novel taxaneterpine compounds
WO2007049575A1 (ja) * 2005-10-25 2007-05-03 Daiichi Sankyo Company, Limited アゼチジン環構造を有するタキサン化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHU Q. ET AL.: "Comparative molecular field analysis of a serious of paclitaxel analogs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 26, 1997, pages 4319 - 4328 *

Also Published As

Publication number Publication date
TW200901967A (en) 2009-01-16

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