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WO2008117775A1 - Taxanes having oxetane ring structure - Google Patents

Taxanes having oxetane ring structure Download PDF

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Publication number
WO2008117775A1
WO2008117775A1 PCT/JP2008/055428 JP2008055428W WO2008117775A1 WO 2008117775 A1 WO2008117775 A1 WO 2008117775A1 JP 2008055428 W JP2008055428 W JP 2008055428W WO 2008117775 A1 WO2008117775 A1 WO 2008117775A1
Authority
WO
WIPO (PCT)
Prior art keywords
taxanes
ring structure
oxetane ring
cancer
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/055428
Other languages
French (fr)
Japanese (ja)
Inventor
Kouichi Uoto
Yasuyuki Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of WO2008117775A1 publication Critical patent/WO2008117775A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides novel extremely safe taxane anticancer agents having high antitumor activity. Taxanes having oxetane ring structure which are represented by the general formula (1); drugs containing the taxanes; pharmaceutical compositions containing the taxanes; and a method of treatment of cancer with the taxanes. (1)
PCT/JP2008/055428 2007-03-27 2008-03-24 Taxanes having oxetane ring structure Ceased WO2008117775A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-081742 2007-03-27
JP2007081742 2007-03-27

Publications (1)

Publication Number Publication Date
WO2008117775A1 true WO2008117775A1 (en) 2008-10-02

Family

ID=39788510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055428 Ceased WO2008117775A1 (en) 2007-03-27 2008-03-24 Taxanes having oxetane ring structure

Country Status (2)

Country Link
TW (1) TW200901967A (en)
WO (1) WO2008117775A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07233159A (en) * 1993-12-20 1995-09-05 Dai Ichi Seiyaku Co Ltd Taxol derivative
JPH08503219A (en) * 1992-11-13 1996-04-09 フロリダ・ステート・ユニバーシティー Taxane having alkyl-substituted side chain and pharmaceutical composition containing the same
JPH0912578A (en) * 1995-04-28 1997-01-14 Dai Ichi Seiyaku Co Ltd Pentacyclic compound
WO1999037631A1 (en) * 1998-01-26 1999-07-29 Hanmi Pharmaceutical Co., Ltd. Novel taxaneterpine compounds
WO2007049575A1 (en) * 2005-10-25 2007-05-03 Daiichi Sankyo Company, Limited Taxane compound with azetidine ring structure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503219A (en) * 1992-11-13 1996-04-09 フロリダ・ステート・ユニバーシティー Taxane having alkyl-substituted side chain and pharmaceutical composition containing the same
JPH07233159A (en) * 1993-12-20 1995-09-05 Dai Ichi Seiyaku Co Ltd Taxol derivative
JPH0912578A (en) * 1995-04-28 1997-01-14 Dai Ichi Seiyaku Co Ltd Pentacyclic compound
WO1999037631A1 (en) * 1998-01-26 1999-07-29 Hanmi Pharmaceutical Co., Ltd. Novel taxaneterpine compounds
WO2007049575A1 (en) * 2005-10-25 2007-05-03 Daiichi Sankyo Company, Limited Taxane compound with azetidine ring structure

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHU Q. ET AL.: "Comparative molecular field analysis of a serious of paclitaxel analogs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 26, 1997, pages 4319 - 4328 *

Also Published As

Publication number Publication date
TW200901967A (en) 2009-01-16

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