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WO2008117123A3 - Procédé perfectionné pour préparer la forme polymorphe i du chlorhydrate de donépézil - Google Patents

Procédé perfectionné pour préparer la forme polymorphe i du chlorhydrate de donépézil Download PDF

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Publication number
WO2008117123A3
WO2008117123A3 PCT/IB2007/004566 IB2007004566W WO2008117123A3 WO 2008117123 A3 WO2008117123 A3 WO 2008117123A3 IB 2007004566 W IB2007004566 W IB 2007004566W WO 2008117123 A3 WO2008117123 A3 WO 2008117123A3
Authority
WO
WIPO (PCT)
Prior art keywords
donepezil hydrochloride
polymorphic form
hydrochloride polymorphic
preparing donepezil
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/004566
Other languages
English (en)
Other versions
WO2008117123A2 (fr
Inventor
Madrid Nuria Soldevilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Publication of WO2008117123A2 publication Critical patent/WO2008117123A2/fr
Publication of WO2008117123A3 publication Critical patent/WO2008117123A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention porte sur des procédés perfectionnés pour la préparation de la Forme polymorphe I de chlorhydrate du 2,3- dihydro-5,6-diméthoxy-2-[[ 1 -(phénylméthyl)-4-pipéridinyl]méthyl- 1H-indén- 1 -one (à savoir le chlorhydrate de donépézil).
PCT/IB2007/004566 2006-10-16 2007-10-16 Procédé perfectionné pour préparer la forme polymorphe i du chlorhydrate de donépézil Ceased WO2008117123A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85175706P 2006-10-16 2006-10-16
US60/851,757 2006-10-16
US92919507P 2007-06-18 2007-06-18
US60/929,195 2007-06-18

Publications (2)

Publication Number Publication Date
WO2008117123A2 WO2008117123A2 (fr) 2008-10-02
WO2008117123A3 true WO2008117123A3 (fr) 2008-12-04

Family

ID=39712458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004566 Ceased WO2008117123A2 (fr) 2006-10-16 2007-10-16 Procédé perfectionné pour préparer la forme polymorphe i du chlorhydrate de donépézil

Country Status (2)

Country Link
AR (1) AR063319A1 (fr)
WO (1) WO2008117123A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060752B (zh) * 2011-01-24 2013-03-13 上海右手医药科技开发有限公司 高纯度盐酸多奈哌齐无水i晶型的生产方法及其产品
CN103694164B (zh) * 2014-01-23 2015-08-12 天津大学 一种盐酸多奈哌齐新晶型及制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046526A1 (fr) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Polymorphes stables d'hydrochlorure de 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-piperidine), dit hydrochlorure de donepezil et procede pour leur production
WO2006090263A1 (fr) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Chlorhydrate de donepezil de formule i stable et son procede de preparation et d'utilisation dans des compositions pharmaceutiques
WO2007072087A2 (fr) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Nouveau procédé pour la production de chlorhydrate de donépézil polymorphe (i) extrêmement pur
WO2007119118A2 (fr) * 2005-11-14 2007-10-25 Medichem S.A. Synthèse améliorée et préparations d'intermédiaires et de nouveaux polymorphes correspondants utilisés dans la production de chlorhydrate de donépézil

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046526A1 (fr) * 1996-06-07 1997-12-11 Eisai Co., Ltd. Polymorphes stables d'hydrochlorure de 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl-piperidine), dit hydrochlorure de donepezil et procede pour leur production
WO2006090263A1 (fr) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Chlorhydrate de donepezil de formule i stable et son procede de preparation et d'utilisation dans des compositions pharmaceutiques
WO2007119118A2 (fr) * 2005-11-14 2007-10-25 Medichem S.A. Synthèse améliorée et préparations d'intermédiaires et de nouveaux polymorphes correspondants utilisés dans la production de chlorhydrate de donépézil
WO2007072087A2 (fr) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Nouveau procédé pour la production de chlorhydrate de donépézil polymorphe (i) extrêmement pur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUGIMOTO, H. ET AL.: "Donepezil Hydrochloride (E2020) and Other Acetlycholinesterase Inhibitors", CURRENT MEDICINAL CHEMISTRY, vol. 7, 2000, pages 303 - 339, XP002497889 *

Also Published As

Publication number Publication date
WO2008117123A2 (fr) 2008-10-02
AR063319A1 (es) 2009-01-21

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