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WO2008114577A3 - 抗菌性ペプチド - Google Patents

抗菌性ペプチド Download PDF

Info

Publication number
WO2008114577A3
WO2008114577A3 PCT/JP2008/053211 JP2008053211W WO2008114577A3 WO 2008114577 A3 WO2008114577 A3 WO 2008114577A3 JP 2008053211 W JP2008053211 W JP 2008053211W WO 2008114577 A3 WO2008114577 A3 WO 2008114577A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
integer
gly
amino acid
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053211
Other languages
English (en)
French (fr)
Other versions
WO2008114577A2 (ja
Inventor
Masao Tanihara
Keiko Ida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nara Institute of Science and Technology NUC
PHG Corp
Original Assignee
Nara Institute of Science and Technology NUC
PHG Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nara Institute of Science and Technology NUC, PHG Corp filed Critical Nara Institute of Science and Technology NUC
Priority to JP2009505105A priority Critical patent/JP5354206B2/ja
Publication of WO2008114577A2 publication Critical patent/WO2008114577A2/ja
Publication of WO2008114577A3 publication Critical patent/WO2008114577A3/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)

Abstract

安定性が高く、優れた抗菌性活性を有するペプチド又はその塩を提供する。 以下の（１）又は（２）で表されるペプチド又はその塩； （１）下記一般式（I）で表されるアミノ酸配列からなるペプチド (Pro Hyp Gly)n-｛(Lys X Gly)m-(Pro Hyp Gly)l-(Lys X Gly)p｝α-(Pro Hyp Gly)r　　（I） （ここで、式（I）中、ｎは１～６の整数であり、ｍは１～４の整数であり、ｌは０～７の整数であり、ｐは１～４の整数であり、ｒは１～６の整数であり、αは１～６の整数である。 Ｘは、Ｉｌｅ、Ｌｅｕ及びＨｙｐから選択されるいずれかのアミノ酸残基であり、 ｍ＋ｐ個のＸは、それぞれ同一又は異なっていてもよい。 ｎ＋ｍ＋ｌ＋ｐ＋ｒ＝４～１５である。 但し、ｌ＝０の時、ｍ＋ｐ≧２を満たし、 α≧２のときｍ＝１、ｌ＝０、ｐ＝１を満たす。） （２）一般式（I）で表されるアミノ酸配列において、Lys、Gly及びX以外の１～３個のアミノ酸残基が置換、欠失若しくは付加されたアミノ酸配列からなり、かつ抗菌活性を有するペプチド。
PCT/JP2008/053211 2007-02-26 2008-02-25 抗菌性ペプチド Ceased WO2008114577A2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009505105A JP5354206B2 (ja) 2007-02-26 2008-02-25 抗菌性ペプチド

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-045490 2007-02-26
JP2007045490 2007-02-26

Publications (2)

Publication Number Publication Date
WO2008114577A2 WO2008114577A2 (ja) 2008-09-25
WO2008114577A3 true WO2008114577A3 (ja) 2008-11-27

Family

ID=39766594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053211 Ceased WO2008114577A2 (ja) 2007-02-26 2008-02-25 抗菌性ペプチド

Country Status (2)

Country Link
JP (1) JP5354206B2 (ja)
WO (1) WO2008114577A2 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015091760A (ja) * 2012-01-23 2015-05-14 学校法人早稲田大学 コラーゲン様ペプチドからなる薬物担体
CN110079531B (zh) * 2019-04-26 2022-09-20 安阳工学院 一种抗菌肽及其应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11215983A (ja) * 1998-01-30 1999-08-10 Agriculture Forestry And Fisheries Technical Information Society ペプチドを有効成分とする抗真菌剤
JPH11335396A (ja) * 1998-03-25 1999-12-07 Seikagaku Kogyo Co Ltd 新規抗菌性ペプチド
JP2000319300A (ja) * 1999-05-14 2000-11-21 Meiji Milk Prod Co Ltd 抗菌性ペプチド
JP2003321500A (ja) * 2002-02-28 2003-11-11 Sentomedo:Kk 新規なポリペプチドおよびその製造方法
JP2005060550A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 被膜形成組成物
JP2005206542A (ja) * 2004-01-23 2005-08-04 Masao Tanihara 新規なポリペプチド及びその製造方法
JP2006045214A (ja) * 2004-07-06 2006-02-16 Juntendo 抗菌性ペプチド
WO2007010623A1 (ja) * 2005-07-22 2007-01-25 Phg Corporation 新規なポリペプチド及びその製造方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11215983A (ja) * 1998-01-30 1999-08-10 Agriculture Forestry And Fisheries Technical Information Society ペプチドを有効成分とする抗真菌剤
JPH11335396A (ja) * 1998-03-25 1999-12-07 Seikagaku Kogyo Co Ltd 新規抗菌性ペプチド
JP2000319300A (ja) * 1999-05-14 2000-11-21 Meiji Milk Prod Co Ltd 抗菌性ペプチド
JP2003321500A (ja) * 2002-02-28 2003-11-11 Sentomedo:Kk 新規なポリペプチドおよびその製造方法
JP2005060550A (ja) * 2003-08-13 2005-03-10 Masao Tanihara 被膜形成組成物
JP2005206542A (ja) * 2004-01-23 2005-08-04 Masao Tanihara 新規なポリペプチド及びその製造方法
JP2006045214A (ja) * 2004-07-06 2006-02-16 Juntendo 抗菌性ペプチド
WO2007010623A1 (ja) * 2005-07-22 2007-01-25 Phg Corporation 新規なポリペプチド及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TANIHARA M. ET AL.: "Sanju Rasen Kozo o Keisei suru Kokinsei Peptide no Sekkei to Gosei", DAI 127 PROCEEDINGS OF THE ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2007 (2007-03-05), pages 79 + ABSTR. NO. 28P1-PM040 *

Also Published As

Publication number Publication date
WO2008114577A2 (ja) 2008-09-25
JP5354206B2 (ja) 2013-11-27
JPWO2008114577A1 (ja) 2010-07-01

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