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WO2008151777A2 - Dépôt de nicotine, notamment conçu pour une cigarette sans fumée, et procédé de fabrication correspondant - Google Patents

Dépôt de nicotine, notamment conçu pour une cigarette sans fumée, et procédé de fabrication correspondant Download PDF

Info

Publication number
WO2008151777A2
WO2008151777A2 PCT/EP2008/004631 EP2008004631W WO2008151777A2 WO 2008151777 A2 WO2008151777 A2 WO 2008151777A2 EP 2008004631 W EP2008004631 W EP 2008004631W WO 2008151777 A2 WO2008151777 A2 WO 2008151777A2
Authority
WO
WIPO (PCT)
Prior art keywords
nicotine
depot
container
smoke
solid substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/004631
Other languages
German (de)
English (en)
Other versions
WO2008151777A3 (fr
Inventor
Dirk Kieslich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bel Air International Corp
Original Assignee
Bel Air International Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bel Air International Corp filed Critical Bel Air International Corp
Publication of WO2008151777A2 publication Critical patent/WO2008151777A2/fr
Publication of WO2008151777A3 publication Critical patent/WO2008151777A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/20—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
    • A24F42/60—Constructional details

Definitions

  • Nicotine depot in particular for a smoke-free cigarette, and process for its preparation
  • the invention relates to a nicotine depot, in particular for a smokeless cigarette, comprising a depot container, wherein the depot container (a) 0.01 mg to 50 mg nicotine, (b) a carrier substance and optionally (c) contains a solid substrate.
  • the invention further relates to a method for producing the nicotine depot and its use for a smokeless cigarette.
  • the invention relates to a smokeless cigarette containing the nicotine depot according to the invention.
  • cigarettes usually consist of tobacco wrapped in paper or a tobacco leaf and a filter element attached to the mouthpiece.
  • tobacco burns out and releases nicotine, which is carried along by the smoke to be inhaled by the smoker.
  • tobacco In the combustion of tobacco other substances are released or produced in addition to nicotine, which are often harmful to health, such as tar, arsenic and cadmium compounds and carcinogenic compounds such as hydrazine, chrysene, formaldehyde, Nietrosamine and the like.
  • the invention thus relates to a nicotine depot comprising a depot container, wherein the depot container (a) 0.01 mg to 20 mg of nicotine,
  • (c) contains a solid substrate.
  • the invention likewise provides a process for producing a nicotine depot comprising a depot container, wherein the depot container
  • (c) contains a solid substrate, comprising the steps of (1) providing a depot container,
  • the depot container of the nicotine depot according to the invention comprises in a preferred embodiment a gas-impermeable material.
  • suitable materials are plastics, metals, glass, wood and / or cardboard.
  • the gas impermeability is preferably ensured by a gas impermeable coating.
  • a storage container made of wood or cardboard can be coated with wax or a varnish.
  • suitable metals are aluminum, iron, steel, copper, nickel, zinc and / or tin.
  • suitable plastics are thermoplastic
  • Plastics such as polyethylene, polypropylene and / or polystyrene.
  • cardboard coated with wax is used as the depot container, wherein in particular the wax layer is applied to the container inside.
  • the storage containers are preferably cylindrical and usually adapted to the dimensions of conventional cigarettes.
  • the storage containers preferably have a length of from 10 mm to 80, more preferably from 20 to 60 mm, even more preferably from 25 to 50 mm.
  • the depot containers also have a cross section of 5 to 10 mm, more preferably 6 to 8 mm.
  • the depot container is biodegradable.
  • the nicotine depots according to the invention contain nicotine (constituent (a)) in an amount of 0.01 mg to 20 mg.
  • nicotine stands for (S) -3- [N-methyl-2-pyrrolidyl] -pyridine. Nicotine has the following structure:
  • the nicotine depots of the invention contain nicotine in an amount of from 0.1 to 10 mg, more preferably from 0.2 to 5 mg, even more preferably from 0.3 to 4 mg, most preferably from 0.4 to 3 mg , in particular from 0.5 to 2 mg.
  • the nicotine depots according to the invention also contain a carrier substance (component (b)).
  • a carrier substance usually organic compounds, preferably having a molecular weight of less than 500 g / mol, more preferably less than 200 g / mol are suitable.
  • nicotine is soluble in the vehicle, in particular the amount of nicotine used is completely soluble in the amount of vehicle used.
  • a carrier substance may comprise both a pure substance and a mixture of substances.
  • the carrier is already present at low temperatures, such as at room temperature, which is usually at 21 0 C, at least partially in its gas phase.
  • the proportion of the gas phase at a temperature of 21 ° C can be up to 90%.
  • the proportion is in a range of 10 to 80%, preferably 30 to 60%, particularly preferably at least 50%.
  • the carrier should also be in their Gas phase to be suitable to take the nicotine in sufficient quantity so that the user can take the desired predetermined amount of nicotine upon inhalation of the gaseous carrier substance.
  • the carrier substance has a boiling point of 0 ° C to 200 0 C, more preferably from 30 0 C to 120 0 C, in particular from 50 0 C to 80 0 C.
  • the carrier substance is preferably pharmaceutically acceptable. Furthermore, the carrier substance is preferably low in odor.
  • suitable carrier substances are water, alcohols (in particular primary alcohols), esters, ethers, aldehydes, ketones, hydrocarbons and mixtures thereof.
  • water, methanol, ethanol, propanol (in particular isopropanol), ethyl acetate, diethyl ether, acetaldehyde, aldol, paraldehyde, acetone, pentane, hexane, octane and mixtures thereof may preferably be used as the carrier substance.
  • ethanol or a mixture of ethanol and water are used as the carrier.
  • a mixture of ethanol and water comprises 10 to 99% by weight of ethanol, more preferably 50 to 98% by weight of ethanol, even more preferably 60 to 97% by weight of ethanol, in particular 70 to 96% by weight. of ethanol.
  • the nicotine depots according to the invention contain the carrier substance (b) usually in an amount of from 0.01 mg to 50 mg, preferably from 0.1 mg to 10 mg, more preferably from 0.2 to 5 mg, even more preferably from 0.3 to 3 mg and especially from 0.5 to 2 mg.
  • the nicotine depots according to the invention also optionally contain a solid substrate (component (c)).
  • the solid substrate is preferably a substance or a mixture of substances which can at least partially adsorb and / or absorb the carrier substance.
  • the substrate may be, for example, fibers, nonwovens or (e.g., platelet or powdered) fillers.
  • the substrate is biodegradable.
  • suitable fibers are glass fibers, mineral fibers, natural fibers (such as cotton, wool, flax, jute or sisal), modified natural fibers (such as cellulose acetate fibers), and / or synthetic fibers such as polyamide fibers, polyester fibers, polyethylene fibers, polypropylene fibers, carbon fibers or polyurethane fibers act.
  • natural fibers such as cotton, wool, flax, jute or sisal
  • modified natural fibers such as cellulose acetate fibers
  • synthetic fibers such as polyamide fibers, polyester fibers, polyethylene fibers, polypropylene fibers, carbon fibers or polyurethane fibers act.
  • suitable fillers are so-called glass flakes or mineral substances such as silicates (for example zeolites, mica or mica). Also possible are sintered porous bodies of metals, minerals or plastics as a solid substrate (c).
  • the solid substrate (c) may contain a nonwoven fabric.
  • Nonwoven fabric is understood as meaning a layer, a nonwoven and / or a batt of directionally arranged or randomly located fibers, solidified by friction and / or cohesion and / or adhesion.
  • a material is to be considered as "nonwoven fabric 1" for the purposes of this application, if more than 50%, in particular 60 to 90%, of the mass of its fibrous constituent consists of fibers with a length to diameter ratio of more than 300, in particular more than 500.
  • the individual fibers have a diameter of 50 .mu.m to 0.1 .mu.m, preferably from 10 .mu.m to 0.5 .mu.m, in particular from 7 .mu.m to 0.5 .mu.m.
  • the nonwovens (ii) have a thickness of 0.01 to 5 millimeters (mm), more preferably from 0.1 to 2 mm, particularly preferably from 0.2 to 1, 5 mm, in particular from 0.3 up to 1 mm, measured according to ISO 9073-2.
  • the nonwovens (ii) have a basis weight of from 20 to 500 g / m 2 , more preferably from 50 to 250 g / m 2 , particularly preferably from 90 to 160 g / m 2 , measured to ISO 9073-1 on.
  • solid substrate (c) it is also possible to use products which have been woven, knitted, tufted, stitched together with binding yarns or filaments or felted by wet-rolling.
  • the amount of solid substrate used usually depends on the size of the depot container.
  • the solid substrate (c) is usually used in an amount such that it fills the volume of the depot container at 10 to 100%, preferably at 20 to 90%.
  • the nicotine depots according to the invention can be prepared by a process comprising the following steps: (1) providing a depot container, (2) optionally introducing a solid substrate,
  • the introduction of nicotine (a) and carrier (b) is preferably carried out by spraying or dropping.
  • the closure of the depot container is preferably carried out by closing with a gas-impermeable film.
  • a gas-impermeable film This is preferably a plastic film or a metal foil.
  • the storage container can also be made by spraying a paint system, the paint system forms a gas-impermeable layer after curing. This is preferably a biodegradable paint system.
  • the paint system is preferably curable by UV irradiation.
  • the invention furthermore relates to the use of the nicotine depot according to the invention for a smoke-free cigarette.
  • the nicotine depots according to the invention are here preferably used as disposable nicotine depots.
  • the subject of the invention is smokeless cigarette with a sleeve-shaped cigarette body and a Nicotindepot variouser located in the cigarette body, wherein the Nicotindepot actuallyer (a) 0.01 mg to 20 mg of nicotine, (b) a carrier substance, and optionally (c) contains a solid substrate.
  • the nicotine depot used is a disposable depot, which can be replaced after delivery of the nicotine by a corresponding Nicotine depot.
  • Example 1 Preparation of a nicotine depot
  • Example 2 Use of the nicotine depot in a smokeless cigarette
  • the amount of nicotine in "smoke condensates” was determined on the basis of ISO 4387 and ISO 10315. To this end, a nicotine depot produced according to Example 1 was tested in the smoking machine LM 1 (Borgwaldt-KC) Two smoke ducts with 30 strokes each were carried out. A Nicotindragging in the performed trains gave a total nicotine amount of 0.6 mg.

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

La présente invention concerne un dépôt de nicotine, notamment conçu pour une cigarette sans fumée, lequel dépôt comprend un réservoir de dépôt qui contient (a) 0,01 mg à 50 mg de nicotine, (b) une substance de support, et éventuellement (c) un substrat solide. L'invention concerne également un procédé de fabrication du dépôt de nicotine et son utilisation pour une cigarette sans fumée. En outre, l'invention concerne une cigarette sans fumée contenant ledit dépôt de nicotine.
PCT/EP2008/004631 2007-06-11 2008-06-10 Dépôt de nicotine, notamment conçu pour une cigarette sans fumée, et procédé de fabrication correspondant Ceased WO2008151777A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007026853A DE102007026853A1 (de) 2007-06-11 2007-06-11 Nicotindepot, insbesondere für eine rauchfreie Zigarette, sowie Verfahren zu dessen Herstellung
DE102007026853.1 2007-06-11

Publications (2)

Publication Number Publication Date
WO2008151777A2 true WO2008151777A2 (fr) 2008-12-18
WO2008151777A3 WO2008151777A3 (fr) 2009-02-12

Family

ID=40030234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/004631 Ceased WO2008151777A2 (fr) 2007-06-11 2008-06-10 Dépôt de nicotine, notamment conçu pour une cigarette sans fumée, et procédé de fabrication correspondant

Country Status (2)

Country Link
DE (1) DE102007026853A1 (fr)
WO (1) WO2008151777A2 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013037517A3 (fr) * 2011-09-14 2013-07-25 Mueller Christian Utilisation d'un produit fibreux résistant à la chaleur comme produit support dans des pipes à eau et inhalateurs
CN107874324A (zh) * 2018-01-07 2018-04-06 张宇 一种尼古丁纸质纤维素载体及制作方法
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH069497B2 (ja) * 1988-04-28 1994-02-09 大日精化工業株式会社 煙草成形体、その製造方法及びかぎ煙草
US6024097A (en) * 1992-02-20 2000-02-15 J Mom Trust Product for assisting a smoker in giving up the habit
BE1010444A5 (nl) * 1996-07-29 1998-08-04 Daele Johan Van Inrichting en werkwijze voor het inhaleren van nicotine.
DE10321379A1 (de) 2003-05-12 2004-12-30 Nicstic Ag Rauchfreie-Zigarette

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
US12041968B2 (en) 2011-09-06 2024-07-23 Nicoventures Trading Limited Heating smokeable material
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
WO2013037517A3 (fr) * 2011-09-14 2013-07-25 Mueller Christian Utilisation d'un produit fibreux résistant à la chaleur comme produit support dans des pipes à eau et inhalateurs
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US10638792B2 (en) 2013-03-15 2020-05-05 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
US10912331B2 (en) 2013-12-23 2021-02-09 Juul Labs, Inc. Vaporization device systems and methods
US10201190B2 (en) 2013-12-23 2019-02-12 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US10104915B2 (en) 2013-12-23 2018-10-23 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
US10111470B2 (en) 2013-12-23 2018-10-30 Juul Labs, Inc. Vaporizer apparatus
US10117466B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10117465B2 (en) 2013-12-23 2018-11-06 Juul Labs, Inc. Vaporization device systems and methods
US10070669B2 (en) 2013-12-23 2018-09-11 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10058130B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Cartridge for use with a vaporizer device
US10045567B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10264823B2 (en) 2013-12-23 2019-04-23 Juul Labs, Inc. Vaporization device systems and methods
US10058124B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US10701975B2 (en) 2013-12-23 2020-07-07 Juul Labs, Inc. Vaporization device systems and methods
US10045568B2 (en) 2013-12-23 2018-08-14 Juul Labs, Inc. Vaporization device systems and methods
US11752283B2 (en) 2013-12-23 2023-09-12 Juul Labs, Inc. Vaporization device systems and methods
US10667560B2 (en) 2013-12-23 2020-06-02 Juul Labs, Inc. Vaporizer apparatus
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
US10512282B2 (en) 2014-12-05 2019-12-24 Juul Labs, Inc. Calibrated dose control
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US12016393B2 (en) 2015-10-30 2024-06-25 Nicoventures Trading Limited Apparatus for heating smokable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US12219986B2 (en) 2015-10-30 2025-02-11 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US10865001B2 (en) 2016-02-11 2020-12-15 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
USD929036S1 (en) 2016-06-16 2021-08-24 Pax Labs, Inc. Vaporizer cartridge and device assembly
USD913583S1 (en) 2016-06-16 2021-03-16 Pax Labs, Inc. Vaporizer device
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
CN107874324A (zh) * 2018-01-07 2018-04-06 张宇 一种尼古丁纸质纤维素载体及制作方法

Also Published As

Publication number Publication date
DE102007026853A1 (de) 2009-01-08
WO2008151777A3 (fr) 2009-02-12

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