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WO2008149802A1 - アンドログラホリドを有効成分とする抗疲労剤及び経口組成物 - Google Patents

アンドログラホリドを有効成分とする抗疲労剤及び経口組成物 Download PDF

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Publication number
WO2008149802A1
WO2008149802A1 PCT/JP2008/060011 JP2008060011W WO2008149802A1 WO 2008149802 A1 WO2008149802 A1 WO 2008149802A1 JP 2008060011 W JP2008060011 W JP 2008060011W WO 2008149802 A1 WO2008149802 A1 WO 2008149802A1
Authority
WO
WIPO (PCT)
Prior art keywords
fatigue
andrographolide
oral composition
active ingredient
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/060011
Other languages
English (en)
French (fr)
Inventor
Sumio Asami
Kayo Saito
Akifumi Maeda
Norifumi Tateishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Holdings Ltd
Suntory Ltd
Original Assignee
Suntory Holdings Ltd
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Holdings Ltd, Suntory Ltd filed Critical Suntory Holdings Ltd
Priority to EP08777022A priority Critical patent/EP2153831A4/en
Priority to KR1020097025270A priority patent/KR101444497B1/ko
Priority to AU2008258958A priority patent/AU2008258958B2/en
Priority to JP2009517839A priority patent/JP5714227B2/ja
Priority to CN2008800178539A priority patent/CN101742999B/zh
Priority to US12/602,006 priority patent/US8507547B2/en
Publication of WO2008149802A1 publication Critical patent/WO2008149802A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Furan Compounds (AREA)

Abstract

　ヒトや動物等に対して安全で、日常的に継続摂取が可能であり、抗疲労作用を有する、疲労に関連する疾患又は状態の予防又は処置に有効である組成物を提供することを目的とする。本発明は、アンドログラホリドを、所望によりα-リポ酸と共に有効成分として含有する抗疲労剤、並びにアンドログラホリド及びα-リポ酸を含む新規経口組成物を提供する。本発明は、慢性疲労症候群、過労、肉体的疲労、精神的疲労及び臓器疲労の予防又は処置のために有用である。
PCT/JP2008/060011 2007-05-31 2008-05-30 アンドログラホリドを有効成分とする抗疲労剤及び経口組成物 Ceased WO2008149802A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08777022A EP2153831A4 (en) 2007-05-31 2008-05-30 ANTIERMÜDUNGSMITTEL AND ORAL COMPOSITION, BOTH WITH ANDROGRAPHOLIDE AS ACTIVE INGREDIENTS
KR1020097025270A KR101444497B1 (ko) 2007-05-31 2008-05-30 안드로그라폴라이드를 유효 성분으로 하는 항피로제 및 경구 조성물
AU2008258958A AU2008258958B2 (en) 2007-05-31 2008-05-30 Anti-fatigue Agents and Oral Compositions Containing Andrographolide as Active Ingredient
JP2009517839A JP5714227B2 (ja) 2007-05-31 2008-05-30 アンドログラホリドを有効成分とする抗疲労剤及び経口組成物
CN2008800178539A CN101742999B (zh) 2007-05-31 2008-05-30 以穿心莲内酯为有效成分的抗疲劳剂及口服组合物
US12/602,006 US8507547B2 (en) 2007-05-31 2008-05-30 Anti-fatigue agents and oral compositions containing andrographolide as active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007144623 2007-05-31
JP2007-144623 2007-05-31

Publications (1)

Publication Number Publication Date
WO2008149802A1 true WO2008149802A1 (ja) 2008-12-11

Family

ID=40093620

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060011 Ceased WO2008149802A1 (ja) 2007-05-31 2008-05-30 アンドログラホリドを有効成分とする抗疲労剤及び経口組成物

Country Status (9)

Country Link
US (1) US8507547B2 (ja)
EP (1) EP2153831A4 (ja)
JP (1) JP5714227B2 (ja)
KR (1) KR101444497B1 (ja)
CN (1) CN101742999B (ja)
AU (1) AU2008258958B2 (ja)
SG (1) SG184715A1 (ja)
TW (1) TWI487520B (ja)
WO (1) WO2008149802A1 (ja)

Cited By (2)

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JP2014522817A (ja) * 2011-06-24 2014-09-08 ケー−パックス・ファーマシューティカルズ・インコーポレイテッド 慢性疲労の治療用の組成物および方法
JP2020158418A (ja) * 2019-03-26 2020-10-01 小林製薬株式会社 体力低下抑制用の医薬組成物

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US11318949B2 (en) * 2010-06-07 2022-05-03 Affectiva, Inc. In-vehicle drowsiness analysis using blink rate
CN102617527A (zh) * 2012-03-01 2012-08-01 湖北荷普药业股份有限公司 穿琥宁或炎琥宁的制备方法
US20130248557A1 (en) * 2012-03-21 2013-09-26 Cole Alexander Egger Dry Powdered Comestibles and Serving Methods Therefor
CN103478703A (zh) * 2012-06-12 2014-01-01 孔徐生 一种抗疲劳的保健品及其制备方法
CN105639366A (zh) * 2014-11-24 2016-06-08 王慎君 一种抗疲劳饮料及其制备方法
US11986458B1 (en) * 2018-05-11 2024-05-21 HP Ingredients Corp. Natural and synthetic andrographolides compounds for the treatment of skeletal muscular dystrophies
US20220030923A1 (en) * 2020-07-17 2022-02-03 Northern Innovations Holding Corp. Caffeine and Alpha Lipoic Acid Compositions for Enhanced Sensory Effects
US20220151937A1 (en) * 2020-11-18 2022-05-19 NapJitsu, Inc. Composition for nap promotion
KR102482196B1 (ko) * 2021-01-14 2022-12-29 바이오스펙트럼 주식회사 천심련 추출물 또는 안드로그라폴라이드를 유효성분으로 포함하는 일주기 리듬 장애 예방 또는 개선을 위한 조성물
IT202100019619A1 (it) * 2021-07-23 2023-01-23 Apalasol S R L Uso di una formulazione a base acquosa per potenziare le prestazioni sportive e olfattive degli animali

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522817A (ja) * 2011-06-24 2014-09-08 ケー−パックス・ファーマシューティカルズ・インコーポレイテッド 慢性疲労の治療用の組成物および方法
JP2017149760A (ja) * 2011-06-24 2017-08-31 ケー−パックス・ファーマシューティカルズ・インコーポレイテッド 慢性疲労の治療用の組成物および方法
JP2019147826A (ja) * 2011-06-24 2019-09-05 ケー−パックス・ファーマシューティカルズ・インコーポレイテッド 慢性疲労の治療用の組成物および方法
JP2020158418A (ja) * 2019-03-26 2020-10-01 小林製薬株式会社 体力低下抑制用の医薬組成物

Also Published As

Publication number Publication date
TWI487520B (zh) 2015-06-11
AU2008258958B2 (en) 2013-05-16
CN101742999A (zh) 2010-06-16
SG184715A1 (en) 2012-10-30
EP2153831A4 (en) 2010-12-15
US20100144866A1 (en) 2010-06-10
TW200913988A (en) 2009-04-01
JP5714227B2 (ja) 2015-05-07
EP2153831A1 (en) 2010-02-17
KR101444497B1 (ko) 2014-09-24
CN101742999B (zh) 2013-01-09
JPWO2008149802A1 (ja) 2010-08-26
KR20100017603A (ko) 2010-02-16
AU2008258958A1 (en) 2008-12-11
US8507547B2 (en) 2013-08-13

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