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WO2008149201A3 - Stable pharmaceutical composition - Google Patents

Stable pharmaceutical composition Download PDF

Info

Publication number
WO2008149201A3
WO2008149201A3 PCT/IB2008/001421 IB2008001421W WO2008149201A3 WO 2008149201 A3 WO2008149201 A3 WO 2008149201A3 IB 2008001421 W IB2008001421 W IB 2008001421W WO 2008149201 A3 WO2008149201 A3 WO 2008149201A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
stable pharmaceutical
pharmaceutically acceptable
acceptable salt
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2008/001421
Other languages
French (fr)
Other versions
WO2008149201A2 (en
Inventor
Manjusha Ambadas Joshi
Sachin Pundalik Kolhe
Pankaj Umakant Attarde
Nishid Ashok Gangwal
Satish Ramanlal Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emcure Pharmaceuticals Ltd
Original Assignee
Emcure Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emcure Pharmaceuticals Ltd filed Critical Emcure Pharmaceuticals Ltd
Publication of WO2008149201A2 publication Critical patent/WO2008149201A2/en
Publication of WO2008149201A3 publication Critical patent/WO2008149201A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a stable pharmaceutical composition comprising therapeutically effective amounts of amlodipine or its pharmaceutically acceptable salt and benazepril or its pharmaceutically acceptable salt and at least one pharmaceutically acceptable carrier wherein the stability of the composition is achieved by an effective stabilizing amount of a buffering agent.
PCT/IB2008/001421 2007-06-06 2008-06-04 Stable pharmaceutical composition Ceased WO2008149201A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1080MU2007 2007-06-06
IN1080/MUM/2007 2007-06-06

Publications (2)

Publication Number Publication Date
WO2008149201A2 WO2008149201A2 (en) 2008-12-11
WO2008149201A3 true WO2008149201A3 (en) 2009-01-29

Family

ID=39924939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001421 Ceased WO2008149201A2 (en) 2007-06-06 2008-06-04 Stable pharmaceutical composition

Country Status (1)

Country Link
WO (1) WO2008149201A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102058872B (en) * 2009-11-17 2013-12-25 北京万全阳光医学技术有限公司 Medicinal composition containing Lysinopril and amlodipine besilate and preparation method thereof
WO2014122585A1 (en) * 2013-02-08 2014-08-14 Wockhardt Limited A stable pharmaceutical composition of amlodipine and benazepril or salts thereof
WO2024163030A1 (en) * 2023-02-03 2024-08-08 Brillian Pharma Inc. Amlodipine freeze-dried compositions and uses thereof
CN117538461B (en) * 2024-01-10 2024-03-26 地奥集团成都药业股份有限公司 Detection method of related substances of benazepril hydrochloride tablets

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0795327A1 (en) * 1996-03-13 1997-09-17 Pfizer Inc. Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
WO2006097943A2 (en) * 2005-03-15 2006-09-21 Lupin Limited Pharmaceutical compositions of amlodipine and benazepril
US20070071811A1 (en) * 2005-09-28 2007-03-29 Mali Kadosh Stable combinations of amlodipine besylate and benazepril hydrochloride

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0795327A1 (en) * 1996-03-13 1997-09-17 Pfizer Inc. Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
WO2006097943A2 (en) * 2005-03-15 2006-09-21 Lupin Limited Pharmaceutical compositions of amlodipine and benazepril
US20070071811A1 (en) * 2005-09-28 2007-03-29 Mali Kadosh Stable combinations of amlodipine besylate and benazepril hydrochloride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FAULKNER M A ET AL: "AMLODIPINE/BENAZEPRIL: FIXED DOSE COMBINATION THERAPY FOR HYPERTENSION", EXPERT OPINION ON PHARMACOTHERAPY, ASHLEY, LONDON, vol. 2, no. 1, 1 January 2001 (2001-01-01), pages 165 - 178, XP008017494, ISSN: 1465-6566 *

Also Published As

Publication number Publication date
WO2008149201A2 (en) 2008-12-11

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