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WO2008038744A1 - Composition bactéricide - Google Patents

Composition bactéricide Download PDF

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Publication number
WO2008038744A1
WO2008038744A1 PCT/JP2007/068901 JP2007068901W WO2008038744A1 WO 2008038744 A1 WO2008038744 A1 WO 2008038744A1 JP 2007068901 W JP2007068901 W JP 2007068901W WO 2008038744 A1 WO2008038744 A1 WO 2008038744A1
Authority
WO
WIPO (PCT)
Prior art keywords
disinfectant
acid
composition according
weight
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/068901
Other languages
English (en)
Japanese (ja)
Inventor
Katsuhiko Asamori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Publication of WO2008038744A1 publication Critical patent/WO2008038744A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A61L2/186—Peroxide solutions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps

Definitions

  • the present invention relates to a disinfectant composition and a disinfecting method using the same.
  • sodium hypochlorite is an oxygen-based disinfectant such as hydrogen peroxide and hydrogen peroxide in water.
  • Percarbonates, perborates, etc. that generate water are mainly used.
  • these fungicides have various problems.
  • sodium hypochlorite is corrosive to metals, has a handling problem of generating chlorine gas when mixed with acidic substances, and also generates carcinogenic trihalomethanes in the environment. have.
  • Hydrogen peroxide needs to act for a long time at a high concentration in order to obtain a high degree of bactericidal effect.
  • a high bactericidal ability is obtained by using an organic acid in combination with hydrogen peroxide as a bactericidal component.
  • Acetic acid is selected as the organic acid to be used in terms of stability and bactericidal effect, but there are still problems when the irritating odor and the BOD (biochemical oxygen demand) of the wastewater are high.
  • JP-A6-71269 discloses a sterilization method that can disinfect general bacteria in a relatively short time of about 30 minutes by heating a hydrogen peroxide solution of 0.1% or less to 30-60 ° C. It has been done.
  • JP-A 11-76380 discloses a disinfectant cleaning agent for medical equipment comprising hydrogen peroxide, an organic acid, an organic peracid and a stabilizer.
  • US4557898 discloses a composition for sterilizing spores by adding various additives to hydrogen peroxide.
  • JP-A8-225418 discloses a disinfectant comprising silver, an inorganic acid, an organic stabilizer and hydrogen peroxide.
  • the present invention comprises (A) an active oxygen compound (hereinafter referred to as component (A)), (B) an inorganic acid (hereinafter referred to as component (B)), and (C) a nitrate (hereinafter referred to as component (C)).
  • component (A) an active oxygen compound
  • component (B) an inorganic acid
  • component (C) a nitrate
  • component (C) a disinfectant composition that does not contain silver nitrate.
  • the present invention provides a fungicide composition obtained by blending (A) an active oxygen compound, (B) an inorganic acid, and (C) a nitrate, but not containing silver nitrate.
  • the present invention provides a bactericidal product comprising the bactericidal composition as one agent, a bactericidal method comprising bringing the bactericidal composition or the bactericidal product into contact with an object, or the composition Or provide the use of the above product as a disinfectant.
  • JP—A6—71269 is not effective enough when higher bactericidal power is required, such as sterilization of spores.
  • J P-Al-76380 contains organic peracids, so it does not solve the problems of irritating odor and BOD in waste water.
  • heating to about 50 ° C can increase the spore kill rate, but the problem is that the hydrogen peroxide concentration is quite high.
  • JP P-A8-225418 Disinfectant contains silver nitrate and has poor stability.
  • the present invention provides an excellent bactericidal effect against spore bacteria, and can provide a bactericidal composition having a low BOD, for example, capable of killing spore bacteria at a concentration of 10 6 cfuZmL or more. It is providing the sterilization method using such a disinfectant composition.
  • a bactericidal composition having a high bactericidal effect against spore bacteria and capable of killing spore bacteria having a concentration of, for example, 10 6 cfuZmL or more can be obtained.
  • the fungicidal composition of the present invention contains a relatively low concentration of hydrogen peroxide, and further has a reduced BOD component.
  • the present invention has no irritating odor, low BOD, and hydrogen peroxide.
  • a fungicide composition having a reduced concentration of active oxygen compound such as is provided. It also has excellent storage stability.
  • the microorganisms can be sterilized from various objects other than foods and human bodies in which various microorganisms exist.
  • various microorganisms exist for bacteria, enterococcus, Salmonella, Staphylococcus aureus, Pseudomonas aeruginosa, and fungi, black koujikapi, candida, and the like.
  • bacterial spores such as Bacillus subtilis that exhibit strong resistance to fungicides and heat resistance
  • fungal spores such as Aspergillus niger and Candida are targeted.
  • Bacterial spores are dormant cells produced in an environment that is not suitable for growth, and have multiple layered outer shells outside the cells, which are highly resistant to drugs and heat.
  • the fungicidal composition of the present invention provides a high bactericidal effect against these spores.
  • Examples of the active oxygen compound of the present invention include hydrogen peroxide or a compound that generates hydrogen peroxide in water, and hydrogen peroxide is preferable.
  • compounds that generate hydrogen peroxide in water solid compounds such as percarbonate, perborate, in particular sodium percarbonate, sodium perborate, and powdery solids and aqueous hydrogen peroxide solutions are used. it can.
  • Component (A) is effective for sterilization and protein removal.
  • inorganic acids examples include hydrochloric acid, sulfuric acid, nitric acid and phosphoric acid.
  • hydrochloric acid, sulfur The acid, nitric acid and phosphoric acid can be used alone or in combination.
  • Component (B) is effective for sterilization and scale removal.
  • nitrates include alkali metal salts of nitric acid such as sodium nitrate and potassium nitrate, and alkaline earth metal salts of nitric acid such as magnesium nitrate and calcium nitrate, and these can be used alone or in combination. Of these, sodium nitrate, potassium nitrate and magnesium nitrate are preferred.
  • Component (C) is effective for sterilization and fungicidal action. In particular, by coexisting the (A) component and the (B) component with the (C) component, a synergistic effect is obtained in the bactericidal action, and the total of the (A) component, (B) component, and (C) component The amount used can be reduced. However, silver nitrate is not used in the present invention.
  • the fungicide composition of the present invention preferably contains 2 to 20% by weight, more preferably 4 to 10% by weight, particularly 4 to 8% by weight of the component (A) as a high-concentration fungicide composition.
  • the component (B) is preferably contained in an amount of 2 to 20% by weight, more preferably 4 to 15% by weight, and particularly preferably 6 to 12% by weight.
  • the component (C) is preferably contained in an amount of 1 to 20% by weight, more preferably 1 to 10% by weight, and particularly preferably 1 to 5% by weight. Within these ranges, it is easy to handle and excellent in stability.
  • the disinfectant composition of the present invention is obtained by appropriately diluting the disinfectant composition having a high concentration as described above with water, and further heating the disinfectant composition to 35 ° C or more and 70 ° C or less to contact the object. Can be sterilized and washed.
  • the high-concentration fungicide composition is used by diluting 10 to 150 times.
  • the diluting solution of the fungicide composition of the present invention comprises (A) component in an amount of 0.05 to 2.0% by weight, further 0.1 to 1.0% by weight, particularly 0.2 to 0.5%. It is preferable to contain it by weight. Further, the component (B) is preferably contained in an amount of 0.05 to 1.0% by weight, more preferably 0.1 to 0.8% by weight, particularly preferably 0.2 to 0.5% by weight. The component (C) is preferably contained in an amount of 0.02 to 2.0% by weight, more preferably 0.05 to 1.0% by weight, and particularly preferably 0.1 to 0.5% by weight. Within these ranges, a better sterilizing effect can be obtained, the load of wastewater treatment can be reduced, and the economic efficiency can be improved. In addition, when the component (A) and the component (B) are within these ranges, the influence on the apparatus members is small. A composition containing the components (A) to (C) at this concentration can be directly used for sterilization and washing.
  • the disinfectant composition of the present invention can be used for food processing equipment and medical equipment.
  • Medical devices include: artificial dialysis machines (including peripheral devices), endoscopes and other endoscopic instruments such as biopsy forceps, scissors, tweezers, forceps, needle holders, colposcope , Retractors, serpentine tubes, tubes, catheters, carts, etc.
  • the fungicide composition of the present invention is suitable for use in an artificial permeation apparatus.
  • the disinfectant composition of the present invention is preferably used for disinfecting and cleaning an artificial hemodialysis machine.
  • an artificial hemodialysis machine in addition to sterilization, it is required to remove calcium carbonate derived from the dialysate composition and to wash away protein stains removed from the blood by dialysis.
  • endoscopes sterilization and removal of protein stains are required, and the fungicide composition of the present invention It becomes the target of adaptation of things.
  • the calcium carbonate can be removed by the action of the inorganic acid contained in the fungicide composition of the present invention.
  • the active oxygen compound contained therein and further an organic acid [hereinafter referred to as component (D) It can be removed by the action of
  • the component (D) of the present invention citrate, malic acid, tartaric acid, lactic acid, darconic acid, glycolic acid, thioglycolic acid, malonic acid, succinic acid, glutaric acid, maleic acid, crotonic acid, pyruvic acid And mandelic acid.
  • the content of the component (D) is preferably 0.1 to 2% by weight, more preferably 0.2 to 2% by weight, and particularly preferably 0.4 to 1% by weight in a high-concentration fungicide composition. . Within these ranges, it is easy to handle and excellent in stability.
  • the content of the component (D) is 0.02 to 0.2% by weight, more preferably 0.03 to 0.15% by weight, particularly 0.05 to 0.1% by weight in the diluted solution at the time of use. It is preferable because it has excellent protein removability and has little influence on the stability of component (A), especially hydrogen peroxide.
  • the weight ratio of the component (A) to the component (B) is (B) Z (A) 0.1-5, further 0.5-3, In particular, it is preferably 1 to 2,
  • the weight ratio of the component (A) to the component (C) is preferably 0.1 to 5, more preferably 0.2 to 2, and particularly preferably 0.5 to 1 in terms of (C) Z (A).
  • the disinfectant composition of the present invention can be a liquid composition containing the above components (A) to (C) and other components such as the component (D) and water.
  • components other than the component (D) surfactants that do not affect the stability of hydrogen peroxide (especially nonionic surfactants), antifungal agents, hydrogen peroxide stabilizers, etc. It is done.
  • Antifungal agents include aminotril (methylenephosphonic acid) and its salts, 1-hydroxyethylidene-1,1-diphosphonic acid and its salts, ethylenediaminetetra (methylenephosphonic acid) and its salts, and ethylene triamine pens. (Methylene phosphonic acid) and salts thereof.
  • the disinfectant composition of the present invention is subjected to a disinfecting method for bringing the composition into contact with an object at a temperature of 35 ° C. or higher and 70 ° C. or lower.
  • Bacillus subtilis ATC C 6051 is pre-cultured on SCD agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) for 4 weeks at 30 ° C, and then the appropriate amount of the colony formed on the agar medium is scraped off. Suspension in 1 mL of sterile water and microscopic examination confirmed the formation of bacterial spores (hereinafter referred to as spores). This suspension was subjected to centrifugal washing twice, and then adjusted to a bacterial concentration of 10 8 to 10 9 cfu no mL with an appropriate amount of sterile water.
  • 0.111111 ⁇ of this spore suspension was inoculated into 1.9 mL of the sterilizing solution in Table 1 and allowed to act under the sterilizing conditions in Table 1.
  • 0.1 mL of this sterilizing solution was added to 1 mL of SCDLP medium (manufactured by Nippon Pharmaceutical Co., Ltd.) containing 1% by weight of sodium thiosulfate to inactivate the sterilizing solution.
  • the balance of the sterilizing solution in Table 1 is water.
  • Black Aspergillus niger (As pergillusniger I F06341) was pre-cultured on potato dextrose agar (manufactured by Nippon Pharmaceutical Co., Ltd.) at 25 ° C for 4 weeks.
  • the bacterial cells generated on the medium were scraped and suspended uniformly in about 5 mL of sterile water using a glass homogenizer. This suspension was washed twice by centrifugation and then adjusted to a bacterial concentration of 10 7 to 10 8 cf mL with an appropriate amount of sterilized water.
  • 0.1 mL of this spore suspension was inoculated into 1.9 mL of the sterilizing solution shown in Table 2, and allowed to act under the sterilizing conditions shown in Table 2. Immediately thereafter, 0.1 mL of this sterilizing solution was added to 1 mL of SCDLP medium (manufactured by Nippon Pharmaceutical Co., Ltd.) containing 1% sodium thiosulfate to inactivate the sterilizing solution. Spread 0.2 mL of this inactivation solution on a 9 cm diameter potato dextro agar medium, incubate at 25 ° C for 72 hours, and count the number of colonies formed on the medium. The number of remaining viable bacteria was measured. The results are shown in Table 2. The balance of the bactericidal solution in Table 2 is water.
  • a part of the line was replaced with a silicon tube contaminated under the following conditions, the line was assembled in a loop shape so that it could be circulated via a pump, and the sterilizing solution in Table 3 was circulated at the specified temperature. After circulation for a predetermined time, the contaminated silicon tube was removed and the internal contamination degree was evaluated.
  • the circulation conditions of the sterilizing solution were as follows: a circulation time of 40 minutes, a circulation temperature of 40 ° C, and a circulation flow rate of 500 mL. The results are shown in Table 3.
  • the balance of the sterilizing solution in Table 3 is water.
  • a standard dialysis solution (Fuso Yakuhin Kogyo Co., Ltd., Kindly Solution AF-1) was filled in a silicon tube with an inner diameter of 6 mm, and left standing for 3 days. After confirming the precipitation of calcium carbonate, the dialysate was discarded. Further, about 2 mL of horse blood was added to the inner surface of the same silicone tube, and the horse blood was heat-degraded and fixed by placing it horizontally at 60 ° C for 2 hours.
  • the silicone tube was removed, and approximately 5 cm including the blood stain was cut vertically, and the protein adhesion state was visually evaluated by amide black staining.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition bactéricide composée (A) d'un composé d'oxygène actif, (B) d'un acide minéral, (C) et d'un sel de nitrate (autre que le nitrate d'argent).
PCT/JP2007/068901 2006-09-29 2007-09-20 Composition bactéricide Ceased WO2008038744A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-267188 2006-09-29
JP2006267188A JP4963055B2 (ja) 2006-09-29 2006-09-29 殺菌剤組成物

Publications (1)

Publication Number Publication Date
WO2008038744A1 true WO2008038744A1 (fr) 2008-04-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/068901 Ceased WO2008038744A1 (fr) 2006-09-29 2007-09-20 Composition bactéricide

Country Status (3)

Country Link
JP (1) JP4963055B2 (fr)
TW (1) TW200820998A (fr)
WO (1) WO2008038744A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095231A1 (fr) * 2009-02-19 2010-08-26 サラヤ株式会社 Composition acide contenant un oxydant à action anticorrosion sur l'aluminium et son utilisation
CN105836860B (zh) * 2016-05-30 2019-03-15 柴海林 一种稳定型双氧水消毒剂及其在饮用水消毒中的应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6731290B2 (ja) * 2015-06-16 2020-07-29 シーバイエス株式会社 粉末殺菌洗浄剤組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03278837A (ja) * 1990-03-27 1991-12-10 Tome Sangyo Kk 過酸化水素分解触媒およびそれを用いたコンタクトレンズの消毒方法
JP2002532398A (ja) * 1998-12-14 2002-10-02 ヴィロックス テクノロジーズ インコーポレーテッド 高活性を有する過酸化水素系消毒薬
JP2003121805A (ja) * 2001-10-10 2003-04-23 Tomey Corp コンタクトレンズの洗浄及び消毒方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH673225A5 (fr) * 1986-04-22 1990-02-28 Sanosil Ag
JP3237222B2 (ja) * 1992-08-26 2001-12-10 栗田工業株式会社 殺菌方法
JP2006206535A (ja) * 2005-01-31 2006-08-10 Osaka Sasaki Chemical Co Ltd 医療機器用洗浄消毒剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03278837A (ja) * 1990-03-27 1991-12-10 Tome Sangyo Kk 過酸化水素分解触媒およびそれを用いたコンタクトレンズの消毒方法
JP2002532398A (ja) * 1998-12-14 2002-10-02 ヴィロックス テクノロジーズ インコーポレーテッド 高活性を有する過酸化水素系消毒薬
JP2003121805A (ja) * 2001-10-10 2003-04-23 Tomey Corp コンタクトレンズの洗浄及び消毒方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010095231A1 (fr) * 2009-02-19 2010-08-26 サラヤ株式会社 Composition acide contenant un oxydant à action anticorrosion sur l'aluminium et son utilisation
US8574632B2 (en) 2009-02-19 2013-11-05 Saraya Co., Ltd. Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof
US10736323B2 (en) 2009-02-19 2020-08-11 Saraya Co., Ltd. Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof
CN105836860B (zh) * 2016-05-30 2019-03-15 柴海林 一种稳定型双氧水消毒剂及其在饮用水消毒中的应用

Also Published As

Publication number Publication date
JP2008088062A (ja) 2008-04-17
TW200820998A (en) 2008-05-16
JP4963055B2 (ja) 2012-06-27

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