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WO2008038050A3 - Réduction des alpha-halocétones - Google Patents

Réduction des alpha-halocétones Download PDF

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Publication number
WO2008038050A3
WO2008038050A3 PCT/GB2007/050590 GB2007050590W WO2008038050A3 WO 2008038050 A3 WO2008038050 A3 WO 2008038050A3 GB 2007050590 W GB2007050590 W GB 2007050590W WO 2008038050 A3 WO2008038050 A3 WO 2008038050A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
halo
reduction
ketones
halo ketones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2007/050590
Other languages
English (en)
Other versions
WO2008038050A2 (fr
Inventor
Jonathan Wiffen
Brian Adger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALMAC SCIENCES Ltd
Original Assignee
ALMAC SCIENCES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALMAC SCIENCES Ltd filed Critical ALMAC SCIENCES Ltd
Publication of WO2008038050A2 publication Critical patent/WO2008038050A2/fr
Publication of WO2008038050A3 publication Critical patent/WO2008038050A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/222—Phenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention se rapporte à un procédé de réduction des alpha-halocétones en alcools alpha-halo. Elle concerne plus spécifiquement l'utilisation d'enzymes isolées pour la réduction d'alpha-alocétones en alcools alpha-halo correspondants. L'alcool alpha-halo est obtenu à partir de la cétone correspondante de manière stéréosélective avec un rendement correct. La réaction est conduite en présence d'une enzyme isolée ou d'une cellule au repos.
PCT/GB2007/050590 2006-09-29 2007-09-28 Réduction des alpha-halocétones Ceased WO2008038050A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0619240.5 2006-09-29
GB0619240A GB0619240D0 (en) 2006-09-29 2006-09-29 Reduction of alpha-halo ketones

Publications (2)

Publication Number Publication Date
WO2008038050A2 WO2008038050A2 (fr) 2008-04-03
WO2008038050A3 true WO2008038050A3 (fr) 2008-06-26

Family

ID=37434924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/050590 Ceased WO2008038050A2 (fr) 2006-09-29 2007-09-28 Réduction des alpha-halocétones

Country Status (2)

Country Link
GB (1) GB0619240D0 (fr)
WO (1) WO2008038050A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2446025B1 (fr) 2009-06-22 2018-08-08 Codexis, Inc. Voie stéréosélective à médiation par une cétoréductase vers des alpha chloroalcools
WO2011100265A2 (fr) 2010-02-10 2011-08-18 Codexis, Inc. Procédés utilisant des acide aminé déshydrogénases et un système de régénération de cofacteur à base de cétoréductase
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
WO2017001907A1 (fr) * 2015-06-29 2017-01-05 Teva Pharmaceuticals International Gmbh Procédés biocatalytiques de préparation de vilantérol
CN113185429B (zh) * 2021-04-12 2023-06-06 江苏海洋大学 一种抗hiv蛋白酶抑制剂中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0779366A1 (fr) * 1995-06-19 1997-06-18 Kaneka Corporation Procede pour produire des derives 1-halo-3-amino-4-phenyl-2-butanol optiquement actifs
USH1893H (en) * 1996-07-23 2000-10-03 Bristol-Myers Squibb Company Enzymatic reduction method for the preparation of halohydrins
WO2006013801A1 (fr) * 2004-08-06 2006-02-09 Kaneka Corporation Nouvelle carbonyl réductase, gène de celle-ci et procédé d'utilisation de celle-ci
WO2006061137A1 (fr) * 2004-12-09 2006-06-15 Wacker Chemie Ag Gdh mutante ayant une stabilité chimique améliorée
WO2006127180A1 (fr) * 2005-05-25 2006-11-30 Bristol-Myers Squibb Company Procede pour preparer du butane (2r,3s)-1,2-epoxy-3-(protege)amino-4-substitue et des intermediaires de celui-ci

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0779366A1 (fr) * 1995-06-19 1997-06-18 Kaneka Corporation Procede pour produire des derives 1-halo-3-amino-4-phenyl-2-butanol optiquement actifs
USH1893H (en) * 1996-07-23 2000-10-03 Bristol-Myers Squibb Company Enzymatic reduction method for the preparation of halohydrins
WO2006013801A1 (fr) * 2004-08-06 2006-02-09 Kaneka Corporation Nouvelle carbonyl réductase, gène de celle-ci et procédé d'utilisation de celle-ci
EP1792986A1 (fr) * 2004-08-06 2007-06-06 Kaneka Corporation Nouvelle carbonyl reductase, gene de celle-ci et procede d'utilisation de celle-ci
WO2006061137A1 (fr) * 2004-12-09 2006-06-15 Wacker Chemie Ag Gdh mutante ayant une stabilité chimique améliorée
WO2006127180A1 (fr) * 2005-05-25 2006-11-30 Bristol-Myers Squibb Company Procede pour preparer du butane (2r,3s)-1,2-epoxy-3-(protege)amino-4-substitue et des intermediaires de celui-ci

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 14 October 2003 (2003-10-14), KATAOKA ET AL.: "Conjugated polyketone reductase from Candida parapsilosis", XP002465384, retrieved from STN accession no. 2003:804796 *
KALUZNA ET AL: "Ketoreductases: stereoselective catalysts for the facile synthesis of chiral alcohols", TETRAHEDRON: ASYMMETRY, PERGAMON, OXFORD, GB, vol. 16, no. 22, 14 November 2005 (2005-11-14), pages 3682 - 3689, XP005180018, ISSN: 0957-4166 *
PATEL R N ET AL: "Diastereoselective microbial reduction of (S)-[3-chloro-2-oxo-1-(phen ylmethyl)propyl]carbamic acid, 1,1-dimethylethyl ester", TETRAHEDRON: ASYMMETRY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 14, no. 20, 17 October 2003 (2003-10-17), pages 3105 - 3109, XP004464019, ISSN: 0957-4166 *
PATEL R N: "BIOCATALYTIC SYNTHESIS OF CHIRAL INTERMEDIATES FOR ANTIVIRAL AND ANTIHYPERTENSIVE DRUGS", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, AOCS PRESS, CHAMPAIGN, IL, US, vol. 76, no. 11, 1999, pages 1275 - 1281, XP002946859, ISSN: 0003-021X *

Also Published As

Publication number Publication date
GB0619240D0 (en) 2006-11-08
WO2008038050A2 (fr) 2008-04-03

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