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WO2008036420A3 - 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents - Google Patents

9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents Download PDF

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Publication number
WO2008036420A3
WO2008036420A3 PCT/US2007/020611 US2007020611W WO2008036420A3 WO 2008036420 A3 WO2008036420 A3 WO 2008036420A3 US 2007020611 W US2007020611 W US 2007020611W WO 2008036420 A3 WO2008036420 A3 WO 2008036420A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compounds
provides
isothiazolo
diones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/020611
Other languages
French (fr)
Other versions
WO2008036420A2 (en
Inventor
Barton James Bradbury
Qiuping Wang
Jason Allan Wiles
Akihiro Hashimoto
Edlaine Lucien
Godwin Clarence Gilroy Pais
Ha Young Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achillion Pharmaceuticals Inc
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of WO2008036420A2 publication Critical patent/WO2008036420A2/en
Publication of WO2008036420A3 publication Critical patent/WO2008036420A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides compounds and salts of Formula (I) and Formula (II); which possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula (I) and Formula (II). The variables R2, R3, R5, R6, R7, A8 and R9 are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula (I) or Formula (II) and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
PCT/US2007/020611 2006-09-21 2007-09-21 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents Ceased WO2008036420A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82640806P 2006-09-21 2006-09-21
US60/826,408 2006-09-21

Publications (2)

Publication Number Publication Date
WO2008036420A2 WO2008036420A2 (en) 2008-03-27
WO2008036420A3 true WO2008036420A3 (en) 2008-05-22

Family

ID=39092054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020611 Ceased WO2008036420A2 (en) 2006-09-21 2007-09-21 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Country Status (1)

Country Link
WO (1) WO2008036420A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
KR102763706B1 (en) 2015-12-10 2025-02-07 노파르티스 아게 Novel methods and intermediates

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227088A1 (en) * 1985-12-23 1987-07-01 Abbott Laboratories Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives
WO2005019228A1 (en) * 2003-08-12 2005-03-03 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
WO2006084053A1 (en) * 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227088A1 (en) * 1985-12-23 1987-07-01 Abbott Laboratories Isoxazolo-naphthyridine, isoxazolo quinoline, isothiazolonaphthyridine, and isothiazoloquinoline derivatives
WO2005019228A1 (en) * 2003-08-12 2005-03-03 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
WO2006084053A1 (en) * 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
WO2006089054A1 (en) * 2005-02-16 2006-08-24 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents

Also Published As

Publication number Publication date
WO2008036420A2 (en) 2008-03-27

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