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WO2008031888A3 - Condensed pyrimidinones active on glutamatergic receptors - Google Patents

Condensed pyrimidinones active on glutamatergic receptors Download PDF

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Publication number
WO2008031888A3
WO2008031888A3 PCT/EP2007/059721 EP2007059721W WO2008031888A3 WO 2008031888 A3 WO2008031888 A3 WO 2008031888A3 EP 2007059721 W EP2007059721 W EP 2007059721W WO 2008031888 A3 WO2008031888 A3 WO 2008031888A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyrimidinones
condensed
active
glutamatergic receptors
glutamatergic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/059721
Other languages
French (fr)
Other versions
WO2008031888A2 (en
Inventor
Giuseppe Campiani
Stefania Butini
Caterina Fattorusso
Sandra Gemma
Coccone Salvatore Sanna
Marianna Borriello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2008031888A2 publication Critical patent/WO2008031888A2/en
Publication of WO2008031888A3 publication Critical patent/WO2008031888A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a compound of Formula (I) process for its preparation and uses thereof.
PCT/EP2007/059721 2006-09-15 2007-09-14 Condensed pyrimidinones active on glutamatergic receptors Ceased WO2008031888A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2006A000491 2006-09-15
IT000491A ITRM20060491A1 (en) 2006-09-15 2006-09-15 ACTIVE COMPOUNDS ON GLUTAMATERGIC RECEIVERS

Publications (2)

Publication Number Publication Date
WO2008031888A2 WO2008031888A2 (en) 2008-03-20
WO2008031888A3 true WO2008031888A3 (en) 2008-12-18

Family

ID=39092726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/059721 Ceased WO2008031888A2 (en) 2006-09-15 2007-09-14 Condensed pyrimidinones active on glutamatergic receptors

Country Status (2)

Country Link
IT (1) ITRM20060491A1 (en)
WO (1) WO2008031888A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015003881A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicyclic derivatives
CN106470974B (en) 2014-04-17 2019-07-16 韩国巴斯德研究所 Compounds used to treat viral infections
CN112028839B (en) * 2020-09-30 2022-04-12 中国海洋大学 Synthetic method of medicine intermediate cycloparaffin pyrimidine diketone compound

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0884310A1 (en) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazolin-4-one ampa antagonists
EP0884316A1 (en) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazoline-4-one AMPA antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0884310A1 (en) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazolin-4-one ampa antagonists
EP0884316A1 (en) * 1997-06-09 1998-12-16 Pfizer Products Inc. Quinazoline-4-one AMPA antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GIUSEPPE CAMPIANI ET AL.: "1-H-cyclopentapyrimidine-2,4(1H,3H)-dione Derivative (S)-CPW399 as a novel,Potent, and Subtype-selective AMPA Receptor Full Agonist with Partial Desensitization Properties", JOURNAL OF MEDICINAL CHEMISTRY., vol. 44, no. 26, 17 November 2001 (2001-11-17), USAMERICAN CHEMICAL SOCIETY., pages 4501 - 4504, XP002486751 *
KOTAKE Y ET AL: "SYNTHESIS AND ANTITUMOR ACTIVITIES OF NOVEL 6-5 FUSED RING HETEROCYCLE ANTIFOLATES: N-Ä4ÄOMEGA-(2-AMINO-4-SUBSTITUTED-6,7- DIHYDROCYCLOPENTAÄDÜPYRIMIDIN-5-YL)ALKYLÜBENZOYLÜ-L-GLUTAMIC ACIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 37, no. 11, 1 January 1994 (1994-01-01), pages 1616 - 1624, XP002927773, ISSN: 0022-2623 *
LEES G J: "PHARMACOLOGY OF AMPA/KAINATE RECEPTOR LIGANDS AND THEIR THERAPEUTIC POTENTIAL IN NEUROLOGICAL AND PSYCHIATRIC DISORDERS", DRUGS, ADIS INTERNATIONAL LTD, vol. 59, no. 1, 1 January 2000 (2000-01-01), pages 33 - 78, XP009043409, ISSN: 0012-6667 *

Also Published As

Publication number Publication date
ITRM20060491A1 (en) 2008-03-16
WO2008031888A2 (en) 2008-03-20

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