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WO2008015696A3 - Process for preparing ciclesonide - Google Patents

Process for preparing ciclesonide Download PDF

Info

Publication number
WO2008015696A3
WO2008015696A3 PCT/IN2007/000206 IN2007000206W WO2008015696A3 WO 2008015696 A3 WO2008015696 A3 WO 2008015696A3 IN 2007000206 W IN2007000206 W IN 2007000206W WO 2008015696 A3 WO2008015696 A3 WO 2008015696A3
Authority
WO
WIPO (PCT)
Prior art keywords
ciclesonide
preparing
preparing ciclesonide
enriching
enantiomeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000206
Other languages
French (fr)
Other versions
WO2008015696A2 (en
Inventor
Sanjog Ramdharane
Manoj Kumar Singh
Gautam Pal
Malav Gautambhai Shah
Soumitra Banerjee
Ashish Kumar Sarkar
Anant Kumar Manilal Patel
Virendra Kumar Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zydus Lifesciences Ltd
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of WO2008015696A2 publication Critical patent/WO2008015696A2/en
Publication of WO2008015696A3 publication Critical patent/WO2008015696A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

A process for enantiomeric enriching the (R)-Ciclesonide is enclosed. The process comprises providing mixture of (R)-Ciclesonide: (S)-Ciclesonide to chromatography using a chiral stationary phase.
PCT/IN2007/000206 2006-05-23 2007-05-22 Process for preparing ciclesonide Ceased WO2008015696A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN785MU2006 2006-05-23
IN785/MUM/2006 2006-05-23
IN1093MU2006 2006-07-10
IN1093/MUM/2006 2006-07-10
IN1196MU2006 2006-07-28
IN1196/MUM/2006 2006-07-28

Publications (2)

Publication Number Publication Date
WO2008015696A2 WO2008015696A2 (en) 2008-02-07
WO2008015696A3 true WO2008015696A3 (en) 2008-05-29

Family

ID=38997576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000206 Ceased WO2008015696A2 (en) 2006-05-23 2007-05-22 Process for preparing ciclesonide

Country Status (1)

Country Link
WO (1) WO2008015696A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090078329A (en) 2006-09-19 2009-07-17 씨아이피엘에이 엘티디. Process for preparing ciclesonide and its crystalline form
MX2010009303A (en) * 2008-03-13 2010-12-02 Farmabios Spa Process for the preparation of pregnane derivatives.
US20100120733A1 (en) * 2008-11-07 2010-05-13 Auspex Pharmaceuticals, Inc. Steroid modulators of glucocorticoid receptor
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
CN106883283B (en) * 2015-12-15 2021-02-02 天津金耀集团有限公司 Ciclesonide monohydrate, crystal form and preparation method thereof
BR112018074922B1 (en) 2016-06-02 2022-10-25 Abbvie Inc GLUCOCORTICOID RECEPTOR AGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING SUCH COMPOUNDS AND THERAPEUTIC USE THEREOF
CN107778343A (en) * 2016-08-30 2018-03-09 天津太平洋制药有限公司 A kind of preparation method of ciclesonide
KR20200095477A (en) 2017-12-01 2020-08-10 애브비 인코포레이티드 Glucocorticoid receptor agonists and immunoconjugates thereof
CN109293730A (en) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 A kind of preparation method of ciclesonide
CN113117653B (en) * 2021-04-19 2022-03-25 中国科学院兰州化学物理研究所 Preparation and application of carboxylic acid modified cyclodextrin chiral chromatographic stationary phase material

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129535A1 (en) * 1990-09-07 1992-03-12 Elmu Sa Novel PREGNA-1,4-DIEN-3,20-DION-16-17-ACETAL-21-ESTERS, METHOD FOR THE PREPARATION, COMPOSITION, AND METHODS OF TREATMENT
WO1994022899A1 (en) * 1993-04-02 1994-10-13 Byk Gulden Lomberg Chemische Fabrik Gmbh New prednisolone derivates
WO1995024416A1 (en) * 1994-03-09 1995-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel silyl compounds and their use
WO1998009982A1 (en) * 1996-09-03 1998-03-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives
WO2002038584A1 (en) * 2000-11-10 2002-05-16 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
DE10055820C1 (en) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Preparation of 16,17-cyclohexylmethylene-dioxy-pregnadiene derivative, useful as glucocorticoid, by reacting 16,17-ketal with cyclohexylaldehyde to give high epimeric purity
WO2004085460A1 (en) * 2003-03-27 2004-10-07 Altana Pharma Ag Process for preparing crystalline ciclesonide with defined particle size
CN1699395A (en) * 2005-06-21 2005-11-23 浙江仙琚制药股份有限公司 One-pot preparation of prednisolone derivatives
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129535A1 (en) * 1990-09-07 1992-03-12 Elmu Sa Novel PREGNA-1,4-DIEN-3,20-DION-16-17-ACETAL-21-ESTERS, METHOD FOR THE PREPARATION, COMPOSITION, AND METHODS OF TREATMENT
WO1994022899A1 (en) * 1993-04-02 1994-10-13 Byk Gulden Lomberg Chemische Fabrik Gmbh New prednisolone derivates
WO1995024416A1 (en) * 1994-03-09 1995-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel silyl compounds and their use
WO1998009982A1 (en) * 1996-09-03 1998-03-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives
WO2002038584A1 (en) * 2000-11-10 2002-05-16 Altana Pharma Ag Process for the production of 16,17-[(cyclohexylmethylen)bis(oxy)]-11,21-dihydroxy-pregna-1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation
DE10055820C1 (en) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Preparation of 16,17-cyclohexylmethylene-dioxy-pregnadiene derivative, useful as glucocorticoid, by reacting 16,17-ketal with cyclohexylaldehyde to give high epimeric purity
WO2004085460A1 (en) * 2003-03-27 2004-10-07 Altana Pharma Ag Process for preparing crystalline ciclesonide with defined particle size
CN1699395A (en) * 2005-06-21 2005-11-23 浙江仙琚制药股份有限公司 One-pot preparation of prednisolone derivatives
US20070117974A1 (en) * 2005-06-21 2007-05-24 Zhejiang Xianju Pharmaceutical Co., Ltd. One-pot processes for preparing prednisolone derivatives
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GADZALA-KOPCIUCH, R. ET AL: "Silicon dioxide surfaces with aryl interaction sites for chromatographic applications", MATERIALS CHEMISTRY AND PHYSICS , VOLUME DATE 2005, 89(2-3), 228-237 CODEN: MCHPDR; ISSN: 0254-0584, 2004, XP002474702 *

Also Published As

Publication number Publication date
WO2008015696A2 (en) 2008-02-07

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