[go: up one dir, main page]

WO2008013962A3 - Procédé et mélange pour la réticulation photochimique in vivo du collagène - Google Patents

Procédé et mélange pour la réticulation photochimique in vivo du collagène Download PDF

Info

Publication number
WO2008013962A3
WO2008013962A3 PCT/US2007/016952 US2007016952W WO2008013962A3 WO 2008013962 A3 WO2008013962 A3 WO 2008013962A3 US 2007016952 W US2007016952 W US 2007016952W WO 2008013962 A3 WO2008013962 A3 WO 2008013962A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
photochemical cross
vivo
irradiated
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/016952
Other languages
English (en)
Other versions
WO2008013962A9 (fr
WO2008013962A2 (fr
Inventor
Susanna Grafe
Wolfgang Neuberger
Danilo Castro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ceramoptec Industries Inc
Original Assignee
Ceramoptec Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/880,973 external-priority patent/US20090028926A1/en
Application filed by Ceramoptec Industries Inc filed Critical Ceramoptec Industries Inc
Priority to US12/227,079 priority Critical patent/US8263557B2/en
Priority to EP07810866A priority patent/EP2068622A4/fr
Publication of WO2008013962A2 publication Critical patent/WO2008013962A2/fr
Publication of WO2008013962A9 publication Critical patent/WO2008013962A9/fr
Publication of WO2008013962A3 publication Critical patent/WO2008013962A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé et une composition pour la réticulation photochimique du collagène par un agent photoactif in vivo. Le procédé comprend l'administration locale à une zone de traitement d'une formulation photoactive non toxique de la composition avec le collagène, suivie par une irradiation avec une longueur d'onde appropriée. Dans l'un des modes de réalisation, la mTHPC formulée en liposomes est ajoutée au collagène et est irradiée par un laser de 652 nm, conduisant à la production d'échafaudages efficaces de collagène ayant une microstructure renforcée et stabilisée, permettant ainsi d'améliorer les propriétés physico-chimiques de l'échafaudage de collagène. Elle améliore la thermostabilité, la propriété mécanique et le rapport de gonflement de l'échafaudage nouvellement formé. Un collagène photochimiquement réticulé présente un effet antimicrobien, lorsqu'il est irradié par une longueur d'onde appropriée, il désinfecte le site de traitement et réfrène la croissance microbienne.
PCT/US2007/016952 2006-07-28 2007-07-27 Procédé et mélange pour la réticulation photochimique in vivo du collagène Ceased WO2008013962A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/227,079 US8263557B2 (en) 2006-07-28 2007-07-27 Method and mixture for in vivo photochemical cross-linking of collagen
EP07810866A EP2068622A4 (fr) 2006-07-28 2007-07-27 Procédé et mélange pour la réticulation photochimique in vivo du collagène

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83405906P 2006-07-28 2006-07-28
US60/834,059 2006-07-28
US11/880,973 2007-07-25
US11/880,973 US20090028926A1 (en) 2007-07-25 2007-07-25 Method and mixture for in vivo photochemical cross-linking of collagen

Publications (3)

Publication Number Publication Date
WO2008013962A2 WO2008013962A2 (fr) 2008-01-31
WO2008013962A9 WO2008013962A9 (fr) 2008-03-27
WO2008013962A3 true WO2008013962A3 (fr) 2008-12-18

Family

ID=38982115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016952 Ceased WO2008013962A2 (fr) 2006-07-28 2007-07-27 Procédé et mélange pour la réticulation photochimique in vivo du collagène

Country Status (2)

Country Link
EP (1) EP2068622A4 (fr)
WO (1) WO2008013962A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0618475B1 (pt) 2005-11-09 2016-10-11 Klox Technologies Inc composição, método para branqueamento de dentes e kit
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
SG10201703078QA (en) 2008-11-07 2017-05-30 Klox Technologies Inc Combination of an oxidant and a photoactivator for the healing of wounds
WO2011006263A1 (fr) 2009-07-17 2011-01-20 Klox Technologies Inc. Composition orale antibactérienne
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
KR20150082189A (ko) 2012-09-14 2015-07-15 밸리언트 파마슈티컬즈 인터내셔널, 인코퍼레이션 치아미백용 조성물 및 치아미백 방법
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
US10881736B2 (en) 2013-07-03 2021-01-05 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
EP3076902B1 (fr) * 2013-12-03 2025-02-05 Cornell University Procédé pour réparer un espace annulaire, et composition de gel de collagène
KR20160140716A (ko) 2014-04-01 2016-12-07 클록스 테크놀로지스 인크. 조직 필러 조성물 및 사용 방법
JP2018500468A (ja) 2014-10-31 2018-01-11 クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 光活性性の繊維および織物媒体
CN116099049B (zh) * 2023-01-20 2025-01-24 广州希倍医疗科技有限公司 一种改性胶原蛋白支架的制备方法及其产品和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5913884A (en) * 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
US20050175657A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20060099268A1 (en) * 2004-09-14 2006-05-11 University Of Hong Kong Photochemically crosslinked collagen scaffolds and methods for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552452A (en) * 1993-03-15 1996-09-03 Arch Development Corp. Organic tissue glue for closure of wounds
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5913884A (en) * 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
US20050175657A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20060099268A1 (en) * 2004-09-14 2006-05-11 University Of Hong Kong Photochemically crosslinked collagen scaffolds and methods for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2068622A4 *

Also Published As

Publication number Publication date
EP2068622A2 (fr) 2009-06-17
WO2008013962A9 (fr) 2008-03-27
EP2068622A4 (fr) 2012-10-10
WO2008013962A2 (fr) 2008-01-31

Similar Documents

Publication Publication Date Title
WO2008013962A3 (fr) Procédé et mélange pour la réticulation photochimique in vivo du collagène
JP6932304B2 (ja) 発色団およびゲル化剤を含む、創傷を治療するための生体光組成物
WO2008129740A1 (fr) Procédé de contrôle de la pousse de cheveu, et appareil associé au procédé
DE602004019495D1 (de) Infrarot-Strahlung absorbierende Artikel und Methode zu deren Herstellung
WO2006037080A8 (fr) Gel seche sous ultraviolet et procede de production correspondant
BRPI0510599A (pt) compostos, processo para a preparação dos mesmos, composição farmacêutica, uso de um composto, e método para o tratamento e a profilaxia de doenças
MXPA03007665A (es) Polimeros dendriticos novedosos y sus usos biomedicos.
CN101233844A (zh) 一种水性清洁杀菌凝胶
NZ616957A (en) Hemostatic compositions and therapeutic regimens
JP6768525B2 (ja) 熱硬化性生体光組成物およびその使用
ATE415410T1 (de) Pharmazeutische zusammensetzung zur behandlung von psoriasis und anderen hautkrankheiten
BRPI0405732A (pt) Formulações tópicas para tratamento de rosácea
JP5933178B2 (ja) キトサンカルボキシアルキルアミドのヒドロゲル、その調製方法、並びに、無水生成物、皮膚科組成物および美容用組成物
ATE489936T1 (de) Zusammensetzung mit mindestens einem c-glycosid- derivat und mindestens einer hyaluronsäure sowie ihre kosmetische anwendung
Yaron et al. In situ light‐activated materials for skin wound healing and repair: A narrative review
WO2011107283A3 (fr) Formulations à base de taurolidine et procédé de production correspondant
WO2008011473A3 (fr) Compositions et leurs utilisations liées à l'hbxip
AR062140A1 (es) Metodo y mezcla para entrecruzamiento fotoquimico in vivo de colageno
WO2006124686A3 (fr) Modulation de l'expression de stat 6 pour le traitement de l'hyperreactivite bronchique
RU2004103782A (ru) Способ фиксации свободных и перемещенных кожных трансплантаток к подлежащим тканям при пластической хирургии в орбитальной и параорбитальной областях
US20090171262A1 (en) Method and Mixture for In Vivo Photochemical Cross-Linking of Collagen
EP2456465B1 (fr) Système de matériau contenant de l'endoperoxyde avec adaptation de sa désintégration, et ses utilisations
CN115054567B (zh) 一种皮肤创口修护凝胶及其使用方法和应用
DE502006004378D1 (de) Reizlinderndes hustenmittel enthaltend extrakte aus isländischem moos und malve sowie zinkverbindungen
EA200401588A1 (ru) Средство для лечения болезней суставов

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07810866

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12227079

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007810866

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU