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WO2008013962A3 - Method and mixture for in-vivo photochemical cross-linking of collagen - Google Patents

Method and mixture for in-vivo photochemical cross-linking of collagen Download PDF

Info

Publication number
WO2008013962A3
WO2008013962A3 PCT/US2007/016952 US2007016952W WO2008013962A3 WO 2008013962 A3 WO2008013962 A3 WO 2008013962A3 US 2007016952 W US2007016952 W US 2007016952W WO 2008013962 A3 WO2008013962 A3 WO 2008013962A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
photochemical cross
vivo
irradiated
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/016952
Other languages
French (fr)
Other versions
WO2008013962A2 (en
WO2008013962A9 (en
Inventor
Susanna Grafe
Wolfgang Neuberger
Danilo Castro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ceramoptec Industries Inc
Original Assignee
Ceramoptec Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/880,973 external-priority patent/US20090028926A1/en
Application filed by Ceramoptec Industries Inc filed Critical Ceramoptec Industries Inc
Priority to US12/227,079 priority Critical patent/US8263557B2/en
Priority to EP07810866A priority patent/EP2068622A4/en
Publication of WO2008013962A2 publication Critical patent/WO2008013962A2/en
Publication of WO2008013962A9 publication Critical patent/WO2008013962A9/en
Publication of WO2008013962A3 publication Critical patent/WO2008013962A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
PCT/US2007/016952 2006-07-28 2007-07-27 Method and mixture for in-vivo photochemical cross-linking of collagen Ceased WO2008013962A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/227,079 US8263557B2 (en) 2006-07-28 2007-07-27 Method and mixture for in vivo photochemical cross-linking of collagen
EP07810866A EP2068622A4 (en) 2006-07-28 2007-07-27 METHOD AND MIXTURE FOR PHOTOCHEMICAL IN-VIVO NETWORKING OF COLLAGEN

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US83405906P 2006-07-28 2006-07-28
US60/834,059 2006-07-28
US11/880,973 2007-07-25
US11/880,973 US20090028926A1 (en) 2007-07-25 2007-07-25 Method and mixture for in vivo photochemical cross-linking of collagen

Publications (3)

Publication Number Publication Date
WO2008013962A2 WO2008013962A2 (en) 2008-01-31
WO2008013962A9 WO2008013962A9 (en) 2008-03-27
WO2008013962A3 true WO2008013962A3 (en) 2008-12-18

Family

ID=38982115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/016952 Ceased WO2008013962A2 (en) 2006-07-28 2007-07-27 Method and mixture for in-vivo photochemical cross-linking of collagen

Country Status (2)

Country Link
EP (1) EP2068622A4 (en)
WO (1) WO2008013962A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2380239T3 (en) 2005-11-09 2012-05-09 Klox Technologies Inc. Compositions and procedures for teeth whitening
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
NZ631218A (en) 2008-11-07 2016-03-31 Klox Technologies Inc Combination of an oxidant and a photoactivator for the healing of wounds
HRP20171797T1 (en) 2009-07-17 2018-01-26 Klox Technologies Inc. ANTIBACTERIAL ORAL PREPARATION
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
MX351267B (en) 2012-09-14 2017-10-06 Valeant Pharmaceuticals Int Inc Compositions and methods for teeth whitening.
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
JP6932304B2 (en) 2013-07-03 2021-09-08 広東科洛克生物医薬集団有限公司 A bio-light composition for treating wounds, including a chromophore and a gelling agent
CN113663129A (en) 2013-12-03 2021-11-19 康奈尔大学 Method of repairing annulus and collagen gel composition
CN106413766A (en) 2014-04-01 2017-02-15 克洛克斯科技公司 Tissue filler compositions and methods of use
WO2016065488A1 (en) 2014-10-31 2016-05-06 Klox Technologies Inc. Photoactivatable fibers and fabric media
CN116099049B (en) * 2023-01-20 2025-01-24 广州希倍医疗科技有限公司 A preparation method of modified collagen scaffold and its product and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5913884A (en) * 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
US20050175657A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20060099268A1 (en) * 2004-09-14 2006-05-11 University Of Hong Kong Photochemically crosslinked collagen scaffolds and methods for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552452A (en) * 1993-03-15 1996-09-03 Arch Development Corp. Organic tissue glue for closure of wounds
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5913884A (en) * 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
US20050175657A1 (en) * 2003-11-10 2005-08-11 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20060099268A1 (en) * 2004-09-14 2006-05-11 University Of Hong Kong Photochemically crosslinked collagen scaffolds and methods for their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2068622A4 *

Also Published As

Publication number Publication date
WO2008013962A2 (en) 2008-01-31
EP2068622A4 (en) 2012-10-10
EP2068622A2 (en) 2009-06-17
WO2008013962A9 (en) 2008-03-27

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