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WO2008093647A1 - マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法 - Google Patents

マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法 Download PDF

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Publication number
WO2008093647A1
WO2008093647A1 PCT/JP2008/051227 JP2008051227W WO2008093647A1 WO 2008093647 A1 WO2008093647 A1 WO 2008093647A1 JP 2008051227 W JP2008051227 W JP 2008051227W WO 2008093647 A1 WO2008093647 A1 WO 2008093647A1
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Prior art keywords
microarray
organic molecule
interaction
active substance
immobilized
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Ceased
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PCT/JP2008/051227
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English (en)
French (fr)
Inventor
Masato Oikawa
Makoto Sasaki
Yuichi Ogawa
Shin'ichiro Hayashi
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Tohoku University NUC
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Tohoku University NUC
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Priority to JP2008556090A priority Critical patent/JPWO2008093647A1/ja
Publication of WO2008093647A1 publication Critical patent/WO2008093647A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

　固体基板上に固定化された有機分子が多様な方向に存在することを可能とし、有機分子と作用物質との込み入った相互作用を検出することを可能とし、また、方向性に制限がかからないことから構造活性相関の解析をも可能とし、しかも、その製造は簡便、かつ安価に実現することのできる新しい有機分子固定化マイクロアレイとその製造方法並びにこれを用いた作用物質と有機分子との相互作用の検出方法を提供する。 　作用物質との相互作用を検出するための有機分子を固定化したマイクロアレイであって、Ａ：基板にはＢ：有機担体が分子間力相互作用により固定化されていると共に、Ｂ：有機担体にはＣ：有機分子が固定化されているマイクロアレイとする。好適な態様では、このマイクロアレイを用いてテラヘルツ（ＴＨｚ）波の透過、反射および干渉の少なくともいずれかの測定により分析する。
PCT/JP2008/051227 2007-01-31 2008-01-28 マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法 Ceased WO2008093647A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556090A JPWO2008093647A1 (ja) 2007-01-31 2008-01-28 マイクロアレイとその製造方法並びに有機分子と作用物質との相互作用の検出方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-022396 2007-01-31
JP2007022380 2007-01-31
JP2007-022380 2007-01-31
JP2007022396 2007-01-31

Publications (1)

Publication Number Publication Date
WO2008093647A1 true WO2008093647A1 (ja) 2008-08-07

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JP (1) JPWO2008093647A1 (ja)
WO (1) WO2008093647A1 (ja)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010190837A (ja) * 2009-02-20 2010-09-02 Kurabo Ind Ltd ｌｏｇＰの決定方法、および該方法に使用される二相系溶媒
JP2010249564A (ja) * 2009-04-13 2010-11-04 Nippon Telegr & Teleph Corp <Ntt> 溶解性分光測定方法及び溶解性分光測定装置
JP2011506673A (ja) * 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物
JP2011112548A (ja) * 2009-11-27 2011-06-09 Sony Corp 生体サンプル解析方法、生体サンプル解析装置及び生体サンプル解析プログラム
WO2011125355A1 (ja) * 2010-04-01 2011-10-13 株式会社村田製作所 被測定物の特性の測定方法、および、それに用いられるセンシングデバイス
CN108398400A (zh) * 2018-01-18 2018-08-14 河南工业大学 利用太赫兹成像无损检测小麦中脂肪酸含量的方法
JP2020511652A (ja) * 2016-12-01 2020-04-16 ユニバーシティ・オブ・ソウル・インダストリー・コーオパレイション・ファウンデイションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｓｅｏｕｌ Ｉｎｄｕｓｔｒｙ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ テラヘルツ波を用いたｄｎａ分析方法およびｄｎａ分析装置
WO2020080576A1 (ko) * 2018-10-18 2020-04-23 연세대학교 산학협력단 분자 간 상호작용에 의한 흡광도 변화 예측 방법
CN111366555A (zh) * 2020-02-27 2020-07-03 浙江大学 一种耕地土壤中农膜残留的检测方法
WO2022029135A1 (en) * 2020-08-03 2022-02-10 Jt International Sa Measurement method and tag arranged in a smoking article or smoking articles packaging

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11201971A (ja) * 1997-11-09 1999-07-30 Bayer Corp 流体試料中の分析対象物を検出する方法
JP2005233955A (ja) * 2004-02-16 2005-09-02 Samsung Electronics Co Ltd 生体分子を固体基板上に非共有的に固定化する方法及びそれによって製造されるマイクロアレイ
JP2005283143A (ja) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd バイオセンサー
JP2006084422A (ja) * 2004-09-17 2006-03-30 Pentax Corp 透過画像生成方法及び透過画像生成装置
WO2006137824A2 (en) * 2004-08-04 2006-12-28 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11201971A (ja) * 1997-11-09 1999-07-30 Bayer Corp 流体試料中の分析対象物を検出する方法
JP2005233955A (ja) * 2004-02-16 2005-09-02 Samsung Electronics Co Ltd 生体分子を固体基板上に非共有的に固定化する方法及びそれによって製造されるマイクロアレイ
JP2005283143A (ja) * 2004-03-26 2005-10-13 Fuji Photo Film Co Ltd バイオセンサー
WO2006137824A2 (en) * 2004-08-04 2006-12-28 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation
JP2006084422A (ja) * 2004-09-17 2006-03-30 Pentax Corp 透過画像生成方法及び透過画像生成装置

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9791450B2 (en) 2007-12-14 2017-10-17 Biotium, Inc. Fluorescent compounds
JP2011506673A (ja) * 2007-12-14 2011-03-03 バイオティウム， インコーポレイテッド 蛍光性化合物
US9097667B2 (en) 2007-12-14 2015-08-04 Biotium, Inc. Fluorescent compounds
JP2015172199A (ja) * 2007-12-14 2015-10-01 バイオティウム， インコーポレイテッド 蛍光性化合物
JP2010190837A (ja) * 2009-02-20 2010-09-02 Kurabo Ind Ltd ｌｏｇＰの決定方法、および該方法に使用される二相系溶媒
JP2010249564A (ja) * 2009-04-13 2010-11-04 Nippon Telegr & Teleph Corp <Ntt> 溶解性分光測定方法及び溶解性分光測定装置
JP2011112548A (ja) * 2009-11-27 2011-06-09 Sony Corp 生体サンプル解析方法、生体サンプル解析装置及び生体サンプル解析プログラム
WO2011125355A1 (ja) * 2010-04-01 2011-10-13 株式会社村田製作所 被測定物の特性の測定方法、および、それに用いられるセンシングデバイス
JP5859955B2 (ja) * 2010-04-01 2016-02-16 株式会社村田製作所 被測定物の特性の測定方法、および、それに用いられるセンシングデバイス
JP2020511652A (ja) * 2016-12-01 2020-04-16 ユニバーシティ・オブ・ソウル・インダストリー・コーオパレイション・ファウンデイションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｓｅｏｕｌ Ｉｎｄｕｓｔｒｙ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ テラヘルツ波を用いたｄｎａ分析方法およびｄｎａ分析装置
CN108398400A (zh) * 2018-01-18 2018-08-14 河南工业大学 利用太赫兹成像无损检测小麦中脂肪酸含量的方法
CN108398400B (zh) * 2018-01-18 2020-12-22 河南工业大学 利用太赫兹成像无损检测小麦中脂肪酸含量的方法
WO2020080576A1 (ko) * 2018-10-18 2020-04-23 연세대학교 산학협력단 분자 간 상호작용에 의한 흡광도 변화 예측 방법
CN111366555A (zh) * 2020-02-27 2020-07-03 浙江大学 一种耕地土壤中农膜残留的检测方法
CN111366555B (zh) * 2020-02-27 2021-01-26 浙江大学 一种耕地土壤中农膜残留的检测方法
WO2022029135A1 (en) * 2020-08-03 2022-02-10 Jt International Sa Measurement method and tag arranged in a smoking article or smoking articles packaging

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