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WO2008093063A3 - Auto-injecteur - Google Patents

Auto-injecteur Download PDF

Info

Publication number
WO2008093063A3
WO2008093063A3 PCT/GB2008/000287 GB2008000287W WO2008093063A3 WO 2008093063 A3 WO2008093063 A3 WO 2008093063A3 GB 2008000287 W GB2008000287 W GB 2008000287W WO 2008093063 A3 WO2008093063 A3 WO 2008093063A3
Authority
WO
WIPO (PCT)
Prior art keywords
auto injector
outlet portion
adaptor
needle
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/000287
Other languages
English (en)
Other versions
WO2008093063A2 (fr
Inventor
David Drake
Douglas Ivan Jennings
Stuart David Cooper
Timothy Donald Barrow-Williams
Joseph Peter Corrigan
Rosalind Trudy Lee
David Whitaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PA Knowledge Ltd
Original Assignee
PA Knowledge Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0701964A external-priority patent/GB2446778A/en
Priority claimed from GB0715035A external-priority patent/GB0715035D0/en
Application filed by PA Knowledge Ltd filed Critical PA Knowledge Ltd
Priority to JP2009547751A priority Critical patent/JP2010527248A/ja
Priority to US12/525,348 priority patent/US20100036319A1/en
Priority to EP20080701958 priority patent/EP2121083A2/fr
Publication of WO2008093063A2 publication Critical patent/WO2008093063A2/fr
Publication of WO2008093063A3 publication Critical patent/WO2008093063A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
    • A61M2005/3247—Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un auto-injecteur qui comprend : un boîtier; une partie de sortie avec une aiguille mobile par rapport au boîtier; un contenant à l'intérieur du boîtier pour contenir un médicament; et un mécanisme de déploiement actionnable configuré pour déployer la partie de sortie par le déplacement de la partie de sortie par rapport au boîtier et pour éjecter un médicament contenu dans le contenant par la partie de sortie. L'auto-injecteur est configuré pour stocker un volume de fluide et comprend un mécanisme de remplissage configuré pour expulser le volume de fluide à partir de la partie de sortie et, par la suite, pour aspirer le médicament à travers la partie de sortie et dans le contenant. Un adaptateur s'ajuste sur l'auto-injecteur de façon à recouvrir l'aiguille et comprend un élément de perforation configuré pour perforer un flacon, l'élément de perforation assurant une communication de fluide à l'aiguille. L'auto-injecteur et l'adaptateur sont proposés en tant que partie d'un ensemble d'auto-injecteur conjointement avec un flacon contenant une substance qui, en combinaison avec le liquide, forme le médicament et un logement configuré pour recevoir le flacon, l'auto-injecteur et l'adaptateur.
PCT/GB2008/000287 2007-02-01 2008-01-28 Auto-injecteur Ceased WO2008093063A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009547751A JP2010527248A (ja) 2007-02-01 2008-01-28 自動注入器及び自動注入器の針を覆うアダプタ
US12/525,348 US20100036319A1 (en) 2007-02-01 2008-01-28 Auto injector
EP20080701958 EP2121083A2 (fr) 2007-02-01 2008-01-28 Auto-injecteur

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0701964.9 2007-02-01
GB0701964A GB2446778A (en) 2007-02-01 2007-02-01 Syringe adaptor
GB0715035A GB0715035D0 (en) 2007-08-02 2007-08-02 Auto injector
GB0715035.2 2007-08-02

Publications (2)

Publication Number Publication Date
WO2008093063A2 WO2008093063A2 (fr) 2008-08-07
WO2008093063A3 true WO2008093063A3 (fr) 2008-10-30

Family

ID=39311520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000287 Ceased WO2008093063A2 (fr) 2007-02-01 2008-01-28 Auto-injecteur

Country Status (3)

Country Link
EP (1) EP2121083A2 (fr)
JP (1) JP2010527248A (fr)
WO (1) WO2008093063A2 (fr)

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GB2414775B (en) 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414409B (en) 2004-05-28 2009-11-18 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414401B (en) 2004-05-28 2009-06-17 Cilag Ag Int Injection device
GB2427826B (en) 2005-04-06 2010-08-25 Cilag Ag Int Injection device comprising a locking mechanism associated with integrally formed biasing means
GB2424835B (en) 2005-04-06 2010-06-09 Cilag Ag Int Injection device (modified trigger)
GB2425062B (en) 2005-04-06 2010-07-21 Cilag Ag Int Injection device
GB2424836B (en) 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
GB2424838B (en) 2005-04-06 2011-02-23 Cilag Ag Int Injection device (adaptable drive)
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US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
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US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
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CA2778105C (fr) * 2009-10-23 2019-04-02 Amgen Inc. Adaptateur de fiole et systeme
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JP6139697B2 (ja) * 2012-12-21 2017-05-31 ケアベイ・ヨーロッパ・リミテッドＣａｒｅｂａｙ Ｅｕｒｏｐｅ Ｌｉｍｉｔｅｄ 薬剤送達装置
WO2014143815A2 (fr) 2013-03-15 2014-09-18 Amgen Inc. Boîte à médicament, autoinjecteur et système d'autoinjecteur
US10092703B2 (en) 2013-03-15 2018-10-09 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
GB2517896B (en) 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
GB2534619B (en) * 2015-06-22 2017-06-07 C-Major Ltd A module for a sharps retraction device
WO2017102760A1 (fr) 2015-12-14 2017-06-22 F. Hoffmann-La Roche Ag Dispositif d'administration médical
JP7233360B2 (ja) * 2016-08-19 2023-03-06 ベクトン・ディキンソン・アンド・カンパニー ボトルに取り付けるアダプターアセンブリ
AU2021393208A1 (en) * 2020-12-01 2023-07-06 Takeda Pharmaceutical Company Limited Fluid delivery system container and method of use

Citations (12)

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Publication number Priority date Publication date Assignee Title
US2150738A (en) * 1937-10-29 1939-03-14 Leonld A Dunajeff Hypodermic syringe
DE3604826A1 (de) * 1985-02-14 1986-10-16 Technische Hochschule Karl-Marx-Stadt, DDR 9010 Karl-Marx-Stadt Vorrichtung mit tagesmedikamentdepot zur schmerzarmen injektion
US5584819A (en) * 1995-03-13 1996-12-17 Kopfer; Rudolph J. Nested blunt/sharp injection assembly
WO2000025846A2 (fr) * 1998-10-30 2000-05-11 Immunex Corporation Procede et appareil de manipulation de seringue et de flacon a utiliser pour des injections
WO2000062839A2 (fr) * 1999-04-16 2000-10-26 Becton Dickinson And Company Injecteur de type stylo avec caracteristique de combinaison de substances automatisee
DE20013662U1 (de) * 2000-08-08 2001-03-15 Adamaszek, Franz-Heinz, 70193 Stuttgart Etui für Dosier- und automatisches Injektionsgerät
GB2359754A (en) * 2000-03-03 2001-09-05 Nmt Group Plc Needle sheath
US20020173752A1 (en) * 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
WO2003047663A2 (fr) * 2001-11-30 2003-06-12 Elan Pharma International Limited Injecteur automatique
WO2005025636A2 (fr) * 2003-09-17 2005-03-24 Dali Medical Devices Ltd. Dispositif d'injection automatique
US20050137523A1 (en) * 2003-12-22 2005-06-23 Wyatt Philip W. Medicament administration apparatus
WO2005115510A1 (fr) * 2004-05-28 2005-12-08 Cilag Gmbh International Dispositif d'injection

Patent Citations (12)

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Publication number Priority date Publication date Assignee Title
US2150738A (en) * 1937-10-29 1939-03-14 Leonld A Dunajeff Hypodermic syringe
DE3604826A1 (de) * 1985-02-14 1986-10-16 Technische Hochschule Karl-Marx-Stadt, DDR 9010 Karl-Marx-Stadt Vorrichtung mit tagesmedikamentdepot zur schmerzarmen injektion
US5584819A (en) * 1995-03-13 1996-12-17 Kopfer; Rudolph J. Nested blunt/sharp injection assembly
WO2000025846A2 (fr) * 1998-10-30 2000-05-11 Immunex Corporation Procede et appareil de manipulation de seringue et de flacon a utiliser pour des injections
WO2000062839A2 (fr) * 1999-04-16 2000-10-26 Becton Dickinson And Company Injecteur de type stylo avec caracteristique de combinaison de substances automatisee
US20020173752A1 (en) * 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
GB2359754A (en) * 2000-03-03 2001-09-05 Nmt Group Plc Needle sheath
DE20013662U1 (de) * 2000-08-08 2001-03-15 Adamaszek, Franz-Heinz, 70193 Stuttgart Etui für Dosier- und automatisches Injektionsgerät
WO2003047663A2 (fr) * 2001-11-30 2003-06-12 Elan Pharma International Limited Injecteur automatique
WO2005025636A2 (fr) * 2003-09-17 2005-03-24 Dali Medical Devices Ltd. Dispositif d'injection automatique
US20050137523A1 (en) * 2003-12-22 2005-06-23 Wyatt Philip W. Medicament administration apparatus
WO2005115510A1 (fr) * 2004-05-28 2005-12-08 Cilag Gmbh International Dispositif d'injection

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EP2121083A2 (fr) 2009-11-25
JP2010527248A (ja) 2010-08-12

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