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EP2146760B1 - Remplissage de réservoir, gestion des bulles d'air, et systèmes et procédés d'administration de milieu de perfusion associés - Google Patents

Remplissage de réservoir, gestion des bulles d'air, et systèmes et procédés d'administration de milieu de perfusion associés Download PDF

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Publication number
EP2146760B1
EP2146760B1 EP07814386.4A EP07814386A EP2146760B1 EP 2146760 B1 EP2146760 B1 EP 2146760B1 EP 07814386 A EP07814386 A EP 07814386A EP 2146760 B1 EP2146760 B1 EP 2146760B1
Authority
EP
European Patent Office
Prior art keywords
reservoir
bubble trap
volume
plunger
fluidic medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07814386.4A
Other languages
German (de)
English (en)
Other versions
EP2146760A2 (fr
Inventor
Julian D. Kavazov
Sheldon B. Moberg
Benjamin Shen
Truong Gia Luan
Ian B. Hanson
Arsen Ibranyan
Mike Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Minimed Inc
Original Assignee
Medtronic Minimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Minimed Inc filed Critical Medtronic Minimed Inc
Publication of EP2146760A2 publication Critical patent/EP2146760A2/fr
Application granted granted Critical
Publication of EP2146760B1 publication Critical patent/EP2146760B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1413—Modular systems comprising interconnecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs

Definitions

  • Embodiments of the present invention relate to reservoir filling, bubble management, and infusion medium delivery systems.
  • certain chronic diseases may be treated by delivering a medication or other substance to the body of a patient.
  • diabetes is a chronic disease that is commonly treated by delivering defined amounts of insulin to a patient at appropriate times.
  • manually operated syringes and insulin pens have been employed for delivering insulin to a patient.
  • modern systems have been designed to include programmable pumps for delivering controlled amounts of medication to a patient.
  • External pump type delivery devices include devices designed for use in a stationary location, such as a hospital, a clinic, or the like, and further include devices configured for ambulatory or portable use, such as devices that are designed to be carried by a patient, or the like.
  • External pump type delivery devices may be connected in fluid flow communication to a patient or user, for example, through a suitable hollow tubing.
  • the hollow tubing may be connected to a hollow needle that is designed to pierce the skin of the patient and to deliver a fluidic medium there-through. Alternatively, the hollow tubing may be connected directly to the patient as through a cannula, or the like.
  • pump type delivery devices can be significantly more convenient to a patient, in that doses of insulin may be calculated and delivered automatically to a patient at any time during the day or night.
  • insulin pumps may be automatically controlled to provide appropriate doses of a fluidic medium at appropriate times of need, based on sensed or monitored levels of blood glucose.
  • pump type delivery devices have become an important aspect of modern medical treatments of various types of medical conditions, such as diabetes, and the like. As pump technologies improve and doctors and patients become more familiar with such devices, external medical infusion pump treatments are expected to increase in popularity and are expected to increase substantially in number over the next decade.
  • Described arrangements relate to reservoir filling, bubble management, and infusion medium delivery systems.
  • Various embodiments of the present invention are directed to limiting a presence of air bubbles in a fluidic medium expelled from a reservoir.
  • a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir.
  • a plunger head within a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir.
  • a reservoir is vibrated so as to shake air bubbles free in a fluidic medium being filled into the reservoir.
  • a system in accordance with another embodiment of the present invention includes a reservoir.
  • the reservoir includes a body portion, a port, and a bubble trap portion.
  • the body portion has an interior volume for containing a fluidic medium.
  • the port is in fluid flow communication with the interior volume.
  • the bubble trap portion has a volume within the interior of the reservoir in fluid flow communication with the interior volume for trapping air bubbles that are in the fluidic medium as the fluidic medium is being expelled from the interior volume.
  • the port is located to a particular side of the interior volume
  • the bubble trap portion is located to the particular side of the interior volume.
  • the bubble trap portion has a first portion that extends from the body portion away from the interior volume, and a second portion that returns back toward the interior volume.
  • the body portion and the bubble trap portion are a single seamless unit.
  • the bubble trap portion has a first portion that extends from the body portion away from the interior volume, and a second portion that extends from the first portion toward the interior volume.
  • the bubble trap portion includes a curved surface, and the curved surface has a first end region, a second end region, and a middle region between the first end region and the second end region.
  • the first end region and the second end region are closer to the interior volume than the middle region.
  • the first end region is in contact with the body portion, and the second end region is located adjacent to the interior volume of the body portion.
  • the bubble trap portion is shaped approximately as a semi-toroid. Also, in various arrangements, a surface of the bubble trap portion that is in contact with the fluidic medium when the fluidic medium is in the volume of the bubble trap portion is approximately U-shaped. In some arrangements, the bubble trap portion includes a first surface that defines an edge of the volume of the bubble trap portion, and a second surface that defines another edge of the volume of the bubble trap portion, where the second surface is positioned at an angle with respect to the first surface. In further embodiments, the angle between the first surface and the second surface is less than 90 degrees. Also, in further arrangements, the first surface is planar with respect to an inner surface of the body portion.
  • the port is located to a particular side of the interior volume, and a first portion of the bubble trap portion extends from the body portion to the particular side.
  • the first portion is curved, and a second portion of the bubble trap portion extends from an end of the first portion toward the interior volume.
  • the reservoir is shaped such that in order for the fluidic medium to flow from the volume of the bubble trap portion to the port, the fluidic medium must flow through the interior volume.
  • the reservoir further includes a channel that leads from the interior volume to the port, and the bubble trap portion encircles at least a portion of the channel.
  • the system further includes a plunger head having a plunger body portion and a plunger protruding portion, where the plunger head is moveable within the reservoir.
  • a contour of the plunger protruding portion substantially matches an inner contour of the bubble trap portion.
  • the plunger protruding portion has a size such that when the plunger head is fully advanced within the reservoir the plunger protruding portion fills at least 80% of the volume of the bubble trap portion.
  • the plunger protruding portion fills less than 98% of the volume of the bubble trap portion when the plunger head is fully advanced within the reservoir, so that one or more air pockets for holding air exist between the plunger protruding portion and an inner surface of the bubble trap portion when the plunger head is fully advanced within the reservoir.
  • the plunger protruding portion extends at least partially into the volume of the bubble trap portion when the plunger head is sufficiently advanced within the reservoir.
  • the system further includes a plunger head moveable within the reservoir, where the plunger head has a relief for receiving at least a portion of a needle when the plunger head is sufficiently advanced within the reservoir and the portion of the needle is inserted into the reservoir.
  • the reservoir includes at least one of a hydrophobic material and a hydrophilic material on at least part of a surface of the bubble trap portion.
  • the reservoir includes a material for shunting air bubbles in the fluidic medium away from the port and toward the volume of the bubble trap portion when the fluidic medium is being expelled from the interior volume.
  • the system further includes a plunger head moveable within the reservoir, a drive device including a linkage portion and a motor for moving the linkage portion, and a plunger arm connected to the plunger head, where the plunger arm has a mating portion for mating with the linkage portion of the drive device.
  • the system includes a disposable housing for housing the reservoir and for being secured to a user, and a durable housing for housing the motor of the drive device, where the durable housing is configured to be selectively engaged with and disengaged from the disposable housing.
  • FIG. 1 illustrates a generalized representation of a system 10 in accordance with the described arrangements.
  • the system 10 includes a delivery device 12.
  • the system 10 may further include a sensing device 14, a command control device (CCD) 16, and a computer 18.
  • the delivery device 12 and the sensing device 14 may be secured at desired locations on the body 5 of a patient or user 7.
  • the locations at which the delivery device 12 and the sensing device 14 are secured to the body 5 of the user 7 in FIG. 1 are provided only as representative, non-limiting, examples.
  • the delivery device 12 is configured to deliver a fluidic medium to the body 5 of the user 7.
  • the fluidic medium includes a liquid, a fluid, a gel, or the like.
  • the fluidic medium includes a medicine or a drug for treating a disease or a medical condition.
  • the fluidic medium may include insulin for treating diabetes, or may include a drug for treating pain, cancer, a pulmonary disorder, HIV, or the like.
  • the fluidic medium includes a nutritional supplement, a dye, a tracing medium, a saline medium, a hydration medium, or the like.
  • the sensing device 14 includes a sensor, a monitor, or the like, for providing sensor data or monitor data.
  • the sensing device 14 may be configured to sense a condition of the user 7.
  • the sensing device 14 may include electronics and enzymes reactive to a biological condition, such as a blood glucose level, or the like, of the user 7.
  • the sensing device 14 may be secured to the body 5 of the user 7 or embedded in the body 5 of the user 7 at a location that is remote from the location at which the delivery device 12 is secured to the body 5 of the user 7.
  • the sensing device 14 may be incorporated within the delivery device 12.
  • Each of the delivery device 12, the sensing device 14, the CCD 16, and the computer 18 may include transmitter, receiver, or transceiver electronics that allow for communication with other components of the system 10.
  • the sensing device 14 may be configured to transmit sensor data or monitor data to the delivery device 12.
  • the sensing device 14 may also be configured to communicate with the CCD 16.
  • the delivery device 12 may include electronics and software that are configured to analyze sensor data and to deliver the fluidic medium to the body 5 of the user 7 based on the sensor data and/or preprogrammed delivery routines.
  • the CCD 16 and the computer 18 may include electronics and other components configured to perform processing, delivery routine storage, and to control the delivery device 12. By including control functions in the CCD 16 and/or the computer 18, the delivery device 12 may be made with more simplified electronics. However, in some arrangements, the delivery device 12 may include all control functions, and may operate without the CCD 16 and the computer 18. In various embodiments, the CCD 16 may be a portable electronic device. Also, in various arrangements, the delivery device 12 and/or the sensing device 14 may be configured to transmit data to the CCD 16 and/or the computer 18 for display or processing of the data by the CCD 16 and/or the computer 18.
  • FIG. 2 illustrates an example of the system 10.
  • the system 10 in accordance with the arrangement illustrated in FIG. 2 includes the delivery device 12 and the sensing device 14.
  • the delivery device 12 includes a disposable housing 20, a durable housing 30, and a reservoir 40.
  • the delivery device 12 may further include an infusion path 50.
  • a disposable portion of the delivery device 12 may include the disposable housing 20 and the reservoir 40.
  • the disposable portion of the delivery device 12 may be recommended for disposal after a specified number of uses.
  • a durable portion of the delivery device 12 may include the durable housing 30, electronics (not shown in FIG. 2 ), a drive device having a motor and drive linkage (not shown in FIG. 2 ), and the like. Elements of the durable housing portion of the delivery device 12 are typically not contaminated from contact with the user or the fluidic medium during normal operation of the delivery device 12 and, thus, may be retained for re-use with replaced disposable portions of the delivery device 12.
  • the disposable housing 20 supports the reservoir 40 and has a bottom surface (facing downward and into the page in FIG. 2 ) that is configured to secure to the body of a user.
  • An adhesive may be employed at an interface between the bottom surface of the disposable housing 20 and the skin of a user, so as to adhere the disposable housing 20 to the skin of the user.
  • the adhesive may be provided on the bottom surface of the disposable housing 20, with a peelable cover layer covering the adhesive material. In this manner, the cover layer may be peeled off to expose the adhesive material, and the adhesive side of the disposable housing 20 may be placed against the skin of the user.
  • the reservoir 40 is configured for containing or holding a fluidic medium, such as, but not limited to insulin.
  • the reservoir 40 includes a hollow interior volume for receiving the fluidic medium, such as, but not limited to, a cylinder-shaped volume, a tubular-shaped volume, or the like.
  • the reservoir 40 may be provided as a cartridge or canister for containing a fluidic medium.
  • the reservoir 40 is able to be refilled with a fluidic medium.
  • the reservoir 40 may be supported by the disposable housing 20 in any suitable manner.
  • the disposable housing 20 may be provided with projections or struts (not shown), or a trough feature (not shown), for holding the reservoir 40.
  • the reservoir 40 may be supported by the disposable housing 20 in a manner that allows the reservoir 40 to be removed from the disposable housing 20 and replaced with another reservoir.
  • the reservoir 40 may be secured to the disposable housing 20 by a suitable adhesive, a strap, or other coupling structure.
  • the reservoir 40 includes a port 41 for allowing a fluidic medium to flow into and/or flow out of the interior volume of the reservoir 40.
  • the infusion path 50 includes a connector 56, a tube 54, and a needle apparatus 52.
  • the connector 56 of the infusion path 50 may be connectable to the port 41 of the reservoir 40.
  • the disposable housing 20 is configured with an opening near the port 41 of the reservoir 40 for allowing the connector 56 of the infusion path 50 to be selectively connected to and disconnected from the port 41 of the reservoir 40.
  • the port 41 of the reservoir 40 is covered with or supports a septum (not shown in FIG. 2 ), such as a self-sealing septum, or the like.
  • the septum may be configured to prevent a fluidic medium from flowing out of the reservoir 40 through the port 41 when the septum is not pierced.
  • the connector 56 of , the infusion path 50 includes a needle for piercing the septum covering the port 41 of the reservoir 40 so as to allow the fluidic medium to flow out of the interior volume of the reservoir 40. Examples of needle/septum connectors can be found in U.S. Patent Application US 2003/125672 published 3 July 2003 , entitled "Reservoir Connector".
  • the needle apparatus 52 of the infusion path 50 includes a needle that is able to puncture the skin of a user.
  • the tube 54 connects the connector 56 with the needle apparatus 52 and is hollow, such that the infusion path 50 is able to provide a path to allow for the delivery of a fluidic medium from the reservoir 40 to the body of a user.
  • the durable housing 30 of the delivery device 12 includes a housing shell configured to mate with and secure to the disposable housing 20.
  • the durable housing 30 and the disposable housing 20 may be provided with correspondingly shaped grooves, notches, tabs, or other suitable features, that allow the two parts to easily connect together, by manually pressing the two housings together, by twist or threaded connection, or other suitable manner of connecting the parts that is well known in the mechanical arts.
  • the durable housing 30 and the disposable housing 20 may be connected to each other using a twist action.
  • the durable housing 30 and the disposable housing 20 may be configured to be separable from each other when a sufficient force is applied to disconnect the two housings from each other.
  • the disposable housing 20 and the durable housing 30 may be snapped together by friction fitting.
  • a suitable seal such as an o-ring seal, may be placed along a peripheral edge of the durable housing 30 and/or the disposable housing 20, so as to provide a seal against water entering between the durable housing 30 and the disposable housing 20.
  • the durable housing 30 of the delivery device 12 may support a drive device (not shown in FIG. 2 ), including a motor and a drive device linkage portion, for applying a force to the fluidic medium within the reservoir 40 to force the fluidic medium out of the reservoir 40 and into an infusion path, such as the infusion path 50, for delivery to a user.
  • a drive device (not shown in FIG. 2 ), including a motor and a drive device linkage portion, for applying a force to the fluidic medium within the reservoir 40 to force the fluidic medium out of the reservoir 40 and into an infusion path, such as the infusion path 50, for delivery to a user.
  • an electrically driven motor may be mounted within the durable housing 30 with appropriate linkage for operatively coupling the motor to a plunger arm (not shown in FIG. 2 ) connected to a plunger head (not shown in FIG. 2 ) that is within the reservoir 40 and to drive the plunger head in a direction to force the fluidic medium out of the port 41 of the reservoir 40 and to the user.
  • the motor may be controllable to reverse direction so as to move the plunger arm and the plunger head to cause fluid to be drawn into the reservoir 40 from a patient.
  • the motor may be arranged within the durable housing 30 and the reservoir 40 may be correspondingly arranged on the disposable housing 20, such that the operable engagement of the motor with the plunger head, through the appropriate linkage, occurs automatically upon the user connecting the durable housing 30 with the disposable housing 20 of the delivery device 12. Further examples of linkage and control structures may be found in U.S. Patent Application US 2001/ 41869 published 15 November 2001 , entitled "Control Tabs for Infusion Devices and Methods of Using the Same".
  • the durable housing 30 and the disposable housing 20 may be made of suitably rigid materials that maintain their shape, yet provide sufficient flexibility and resilience to effectively connect together and disconnect, as described above.
  • the material of the disposable housing 20 may be selected for suitable compatibility with skin.
  • the disposable housing 20 and the durable housing 30 of the delivery device 12 may be made of any suitable plastic, metal, composite material, or the like.
  • the disposable housing 20 may be made of the same type of material or a different material relative to the durable housing 30.
  • the disposable housing 20 and the durable housing 30 may be manufactured by injection molding or other molding processes, machining processes, or combinations thereof.
  • the disposable housing 20 may be made of a relatively flexible material, such as a flexible silicone, plastic, rubber, synthetic rubber, or the like.
  • a relatively flexible material such as a flexible silicone, plastic, rubber, synthetic rubber, or the like.
  • the delivery device 12 is connected to the sensing device 14 through a connection element 16 of the sensing device 14.
  • the sensing device 14 may include a sensor 15 that includes any suitable biological or environmental sensing device, depending upon a nature of a treatment to be administered by the delivery device 12.
  • the sensor 15 may include a blood glucose sensor, or the like.
  • the sensor 15 may be an external sensor that secures to the skin of a user or, in other arrangements, may be an implantable sensor that is located in an implant site within the body of the user. In further alternatives, the sensor may be included with as a part or along side the infusion cannula and/or needle, such as for example as shown in U.S. Patent Application US 2006/253085 published 9 November 2006 , entitled "Dual Insertion Set".
  • the sensor 15 is an external sensor having a disposable needle pad that includes a needle for piercing the skin of the user and enzymes and/or electronics reactive to a biological condition, such as blood glucose level or the like, of the user.
  • the delivery device 12 may be provided with sensor data from the sensor 15 secured to the user at a site remote from the location at which the delivery device 12 is secured to the user.
  • FIG. 2 While the arrangement shown in FIG. 2 includes a sensor 15 connected by the connection element 16 for providing sensor data to sensor electronics (not shown in FIG. 2 ) located within the durable housing 30 of the delivery device 12, other arrangements may employ a sensor 15 located within the delivery device 12. Yet other arrangements may employ a sensor 15 having a transmitter for communicating sensor data by a wireless communication link with receiver electronics (not shown in FIG. 2 ) located within the durable housing 30 of the delivery device 12.
  • a wireless connection between the sensor 15 and the receiver electronics within the durable housing 30 of the delivery device 12 may include a radio frequency (RF) connection, an optical connection, or another suitable wireless communication link. Further arrangements need not employ the sensing device 14 and, instead, may provide fluidic medium delivery functions without the use of sensor data.
  • RF radio frequency
  • the disposable elements may be arranged on the disposable housing 20, while durable elements may be arranged within a separable durable housing 30.
  • the disposable housing 20 may be separated from the durable housing 30, so that the disposable housing 20 may be disposed of in a proper manner.
  • the durable housing 30 may then be mated with a new (unused) disposable housing 20 for further delivery operation with a user.
  • FIG. 3 illustrates an example of the delivery device 12.
  • the delivery device 12 of the arrangement of FIG. 3 is similar to the delivery device 12 of the arrangement of FIG 2 . While the delivery device 12 in the arrangement illustrated in FIG. 2 provides for the durable housing 30 to cover the reservoir 40, the delivery device 12 in the arrangement of FIG. 3 provides for the durable housing 30 to secure to the disposable housing 20 without covering the reservoir 40.
  • the delivery device 12 of the arrangement illustrated in FIG. 3 includes the disposable housing 20, and the disposable housing 20 in accordance with the arrangement illustrated in FIG. 3 includes a base 21 and a reservoir retaining portion 24. In one arrangement, the base 21 and reservoir retaining portion 24 may be formed as a single, unitary structure.
  • the base 21 of the disposable housing 20 is configured to be secured to the body of a user.
  • the reservoir retaining portion 24 of the disposable housing 20 is configured to house the reservoir 40.
  • the reservoir retaining portion 24 of the disposable housing 20 may be configured to have an opening to allow for the port 41 of the reservoir 40 to be accessed from outside of the reservoir retaining portion 24 while the reservoir 40 is housed in the reservoir retaining portion 24.
  • the durable housing 30 may be configured to be attachable to and detachable from the base 21 of the disposable housing 20.
  • the delivery device 12 in the arrangement illustrated in FIG. 3 includes a plunger arm 60 that is connected to or that is connectable to a plunger head (not shown in FIG. 3 ) within the reservoir 40.
  • FIG. 4 illustrates another view of the delivery device 12 of the embodiment of FIG. 3 .
  • the delivery device 12 of the embodiment illustrated in FIG. 4 includes the disposable housing 20, the durable housing 30, and the infusion path 50.
  • the disposable housing 20 in the embodiment of FIG. 4 includes the base 21, the reservoir retaining portion 24, and a peelable cover layer 25.
  • the peelable cover layer 25 may cover an adhesive material on the bottom surface 22 of the base 21.
  • the peelable cover layer 25 may be configured to be peelable by a user to expose the adhesive material on the bottom surface 22 of the base 21. In some embodiments, there may be multiple adhesive layers on the bottom surface 22 of the base 21 that are separated by peelable layers.
  • the infusion path 50 illustrated in FIG. 4 includes the needle 58 rather than the connector 56, the tube 54, and the needle apparatus 52 as shown in the embodiment of FIG. 2 .
  • the base 21 of the disposable housing 20 may be provided with an opening or pierceable wall in alignment with a tip of the needle 58, to allow the needle 58 to pass through the base 21 and into the skin of a user under the base 21, when extended. In this manner, the needle 58 may be used to pierce the skin of the user and deliver a fluidic medium to the user.
  • the needle 58 may be extended through a hollow cannula (not shown in FIG. 4 ), such that upon piercing the skin of the user with the needle 58, an end of the hollow cannula is guided through the skin of the user by the needle 58. Thereafter, the needle 58 may be removed, leaving the hollow cannula in place, with one end of the cannula located within the body of the user and the other end of the cannula in fluid flow connection with the fluidic medium within the reservoir 40, to convey pumped infusion media from the reservoir 40 to the body of the user.
  • FIG. 5A illustrates a durable portion 8 of the delivery device 12 (refer to FIG. 3 ).
  • FIG. 5B illustrates a section view of the durable portion 8.
  • FIG. 5C illustrates another section view of the durable portion 8.
  • the durable portion 8 includes the durable housing 30, and a drive device 80.
  • the drive device 80 includes a motor 84 and a drive device linkage portion 82.
  • the durable housing 30 may include an interior volume for housing the motor 84, the drive device linkage portion 82, other electronic circuitry, and a power source (not shown in FIGs. 5A, 5B, and 5C ). Also the durable housing 30 may be configured with an opening 32 for receiving a plunger arm 60 (refer to FIG. 3 ). Also, in various embodiments, the durable housing 30 may include one or more connection members 34, such as tabs, insertion holes, or the like, for connecting with the base 21 of the disposable housing 20 (refer to FIG. 3 ).
  • FIG. 6A illustrates a disposable portion 9 of the delivery device 12 (refer to FIG. 3 ).
  • FIG. 6B illustrates a section view of the disposable portion 9.
  • FIG. 6C illustrates another section view of the disposable portion 9.
  • the disposable portion 9 includes the disposable housing 20, the reservoir 40, the plunger arm 60, and a plunger head 70.
  • the disposable housing 20 includes the base 21 and the reservoir retaining portion 24.
  • the base 21 includes a top surface 23 having one or more connection members 26, such as tabs, grooves, or the like, for allowing connections with the one or more connection members 34 of arrangements of the durable housing 30 (refer to FIG. 5B ).
  • the reservoir 40 is housed within the reservoir retaining portion 24 of the disposable housing 20, and the reservoir 40 is configured to hold a fluidic medium.
  • the plunger head 70 is disposed at least partially within the reservoir 40 and is moveable within the reservoir 40 to allow the fluidic medium to fill into the reservoir 40 and to force the fluidic medium out of the reservoir 40.
  • the plunger arm 60 is connected to or is connectable to the plunger head 70.
  • a portion of the plunger arm 60 extends to outside of the reservoir retaining portion 24 of the disposable housing 20.
  • the plunger arm 60 has a mating portion for mating with the drive device linkage portion 82 of the drive device 80 (refer to FIG. 5C ).
  • the durable housing 30 may be snap fitted onto the disposable housing 20, whereupon the drive device linkage portion 82 automatically engages the mating portion of the plunger arm 60.
  • the motor 84 may be controlled to drive the drive device linkage portion 82 and, thus, move the plunger arm 60 to cause the plunger head 70 to move within the reservoir 40.
  • the plunger head 70 may be moved within the reservoir 40 to force the fluidic medium from the reservoir 40 and into the infusion path, so as to deliver the fluidic medium to the body of the user.
  • the reservoir 40 may be refilled with a fluidic medium.
  • the reservoir 40 may be refilled while remaining within the reservoir retaining portion 24 (refer to FIG. 6B ) of the disposable housing 20.
  • the reservoir 40 may be replaced with a new reservoir (not shown), while the disposable housing 20 may be re-used with the new reservoir. In such arrangements, the new reservoir may be inserted into the disposable portion 9.
  • the delivery device 12 includes reservoir status circuitry (not shown), and the reservoir 40 includes reservoir circuitry (not shown).
  • the reservoir circuitry stores information such as, but not limited to, at least one of (i) an identification string identifying the reservoir 40; (ii) a manufacturer of the reservoir 40; (iii) contents of the reservoir 40; and (iv) an amount of contents in the reservoir 40.
  • the delivery device 12 includes the reservoir status circuitry (not shown), and the reservoir status circuitry is configured to read data from the reservoir circuitry when the reservoir 40 is inserted into the disposable portion 9.
  • the reservoir status circuitry is further configured to store data to the reservoir circuitry after at least some of the contents of the reservoir 40 have been transferred out of the reservoir 40, so as to update information in the reservoir circuitry related to an amount of contents still remaining in the reservoir 40.
  • the reservoir status circuitry is configured to store data to the reservoir circuitry, so as to update information in the reservoir circuitry related to an amount of contents still remaining in the reservoir 40, when the reservoir 40 is inserted into the disposable portion 9.
  • the delivery device 12 includes the reservoir status circuitry (not shown) and the reservoir 40 includes the reservoir circuitry (not shown), and the reservoir status circuitry selectively inhibits use of the delivery device 12 or selectively provides a warning signal based on information read by the reservoir status circuitry from the reservoir circuitry.
  • FIGS. 9A , 10A , 11A , 12A , and 12C illustrate systems in accordance with various embodiments of the present invention that include reservoirs with geometries that allow for capturing air bubbles so as to reduce a number of air bubbles that are delivered with a fluidic medium.
  • Such systems allow for air bubble management since they have bubble trapping shapes and, by reducing a number of air bubbles that are delivered with a fluidic medium, such systems may be able to improve a delivery accuracy when attempting to deliver a specified volume of the fluidic medium.
  • Such systems provide reservoir geometries that allow for capturing a greater amount of air bubbles than with standard reservoir geometries, so that the captured air bubbles remain in the reservoir and are not dispensed with the fluidic medium.
  • the systems in FIGS. 9A , 10A , 11A , 12A , and 12C may include similar elements as elements of embodiments of the delivery device 12 (refer to FIGS. 2 and 3 ), in which case the reservoirs in those systems would correspond to the reservoir 40 (refer to FIGS. 2 , 3 , and 6C ).
  • reservoirs of the systems in FIGS. 9A , 10A , 11A , 12A , and 12C may be made of a material, such as but not limited to a suitable metal, plastic, ceramic, glass, composite material, or the like.
  • the plunger heads of the systems in those figures may be made of a suitably rigid material such as, but not limited to, metal, plastic, ceramic, glass, composite material, or the like.
  • the plunger heads in those systems may be made of a compressible material such as, but not limited to, an elastically compressible plastic, rubber, silicone, or the like.
  • FIG. 9A illustrates a cross-sectional view of a system 200 in accordance with an embodiment of the present invention.
  • the system 200 includes a reservoir 210, a plunger head 220, and a plunger arm 230.
  • the reservoir 210 includes a body portion 211, a bubble trap portion 212, and a port 217.
  • the reservoir 210 has an outer surface 213 and an inner surface 214.
  • the inner surface 214 of the reservoir 210 defines a hollow interior of the reservoir 210, and the hollow interior of the reservoir 210 is able to contain a fluidic medium.
  • the port 217 of the reservoir 210 allows for the fluidic medium to be filled into or expelled from the hollow interior of the reservoir 210.
  • the body portion 211 of the reservoir 210 may have any suitable shape, such as but not limited to, a cylinder shape, a tube shape, a barrel shape, a spherical shape, a shape with a rectangular cross-section, or the like.
  • the plunger head 220 is located within the reservoir 210, and is moveable in an axial direction of the reservoir 210, to expand or contract a volume of the reservoir 210 in which a fluidic medium may be contained.
  • the plunger head 220 is connected to the plunger arm 230, such that movement of the plunger arm 230 in the axial direction of the reservoir 210 causes movement of the plunger head 220 in the axial direction of the reservoir 210.
  • the plunger head 220 includes a plunger body portion 221 and a plunger protruding portion 222.
  • the plunger head 220 further includes one or more O-rings 225 that surround a portion of the plunger body portion 221.
  • the one or more O-rings 225 may be made of any suitable material, such as but not limited to, rubber, plastic, composite material, or the like.
  • the bubble trap portion 212 of the reservoir 210 is shaped to have a volume 216 within an interior of the reservoir 210, such that air bubbles in a fluidic medium may be trapped in the volume 216 when the fluidic medium is expelled from the reservoir 210 through the port 217.
  • an interior surface of the bubble trap portion 212 is curved or angled near the port 217, so as to define the volume 216.
  • the bubble trap portion 212 extends from the body portion 211 of the reservoir 210 past a point 218 of the reservoir 210 where a fluidic medium from an interior volume of the body portion 211 is able to move into an area or channel 272 of the reservoir 210 that leads to the port 217.
  • the reservoir 210 is shaped such that as the plunger head 220 is advanced within the reservoir 210, a fluidic medium is able to pass through the port 217 while air bubbles in the reservoir 210 collect in the volume 216 defined by a curved or angled surface of the bubble trap portion 212 of the reservoir 210.
  • a geometry of the reservoir 210 allows for decreasing an amount of air bubbles that are delivered with a fluidic medium as compared with traditional reservoir geometries.
  • the bubble trap portion 212 of the reservoir 210 is curved outward from an interior volume defined by the body portion 211, and a fluidic medium is able to pass directly from the interior volume defined by the body portion 211 to the port 217.
  • a surface 215 of the bubble trap portion 212 of the reservoir 210 includes a surface finish or material such that air bubbles substantially do no stick to the surface 215 and are shunted away from the port 217 toward the volume 216.
  • a surface finish or material includes a hydrophobic material, a hydrophilic material, or other suitable material.
  • the plunger body portion 221 is shaped such that a contour of the plunger body portion 221 substantially matches or is substantially the same as an inner contour of the body portion 211 of the reservoir 210.
  • the plunger body portion 221 has a diameter that is slightly smaller than a diameter of the inner surface of the body portion 211 of the reservoir 210, such that the plunger head 220 is able to slide within the reservoir 210.
  • an O-ring 225 on the plunger body portion 221 is in contact with the inner surface of the body portion 211 of the reservoir 210 when the plunger head 220 is within the reservoir 210.
  • the plunger protruding portion 222 is shaped such that a contour of the plunger protruding portion 222 substantially matches or is substantially the same as an inner contour of the bubble trap portion 212 of the reservoir 210. In some embodiments, the plunger protruding portion 222 is curved and protrudes from the plunger body portion 221. In various embodiments, the plunger protruding portion 222 has a size that is slightly smaller than a region defined by the inner surface of the bubble trap portion 212 of the reservoir 210, such that the plunger protruding portion 222 is able to slide within the volume 216 of the reservoir 210, and such that a space for a dead volume of air is left when the plunger head 220 is fully advanced within the reservoir 210. Thus, in various embodiments, the geometry of the reservoir 210 and the plunger head 220 allow for capturing air bubbles in a volume 216 of the bubble trap portion 212 when a fluidic medium is being expelled from the port 217 of the reservoir 210.
  • the plunger protruding portion 222 has a size such that when the plunger head 220 is fully advanced within the reservoir 210, the plunger protruding portion 222 fills at least 80% of the volume 216 of the bubble trap portion 212. Also, in various embodiments, the plunger protruding portion 222 fills less than 98% of the volume 216 of the bubble trap portion 212 when the plunger head 220 is fully advanced within the reservoir 210, so that one or more air pockets for holding air exist between the plunger protruding portion 222 and an inner surface of the bubble trap portion 212 when the plunger head 220 is fully advanced within the reservoir 210. In some embodiments, the plunger protruding portion 222 extends at least partially into the volume 216 of the bubble trap portion 212 when the plunger head 220 is sufficiently advanced within the reservoir 210.
  • FIG. 9B illustrates a cross-sectional view of the reservoir 210 in accordance with an embodiment of the present invention.
  • FIG. 9B is shaded to highlight various features of the reservoir 210.
  • the reservoir 210 includes the body portion 211, the bubble trap portion 212, and the port 217.
  • the body portion 211 has an interior volume 270 for containing a fluidic medium.
  • the port 217 is in fluid flow communication with the interior volume 270 of the body portion 211.
  • the bubble trap portion 212 has the volume 216 in fluid flow communication with the interior volume 270 of the body portion 211 for trapping air bubbles that are in the fluidic medium as the fluidic medium is being expelled from the interior volume 270.
  • the port 217 is located to a particular side of the interior volume 270
  • the bubble trap portion 212 is located to the particular side of the interior volume 270.
  • the bubble trap portion 212 has a first portion 281 that extends from the body portion 211 away from the interior volume 270, and a second portion 282 that returns back toward the interior volume 270.
  • the body portion 211 and the bubble trap portion 212 are formed together as a single seamless unit.
  • the first portion 281 of the bubble trap portion 212 extends from the body portion 211 away from the interior volume 270 and the second portion 282 of the bubble trap portion 212 extends from the first portion 281 toward the interior volume 270.
  • the bubble trap portion 212 includes a curved surface 283 having a first end region 284, a second end region 285, and a middle region 286 between the first end region 284 and the second end region 285.
  • the first end region 284 and the second end region 285 are closer to the interior volume 270 of the body portion 211 than the middle region 286 is to the interior volume 270.
  • the first end region 284 is in contact with the body portion 211, and the second end region 285 is located adjacent to the interior volume 270 of the body portion 211.
  • the curved surface 283 of the bubble trap portion 212 is in contact with the fluidic medium when the fluidic medium is in the volume 216 of the bubble trap portion 212. In further embodiments, the curved surface 283 is approximately U-shaped. FIG. 9B illustrates a cross-sectional view, but in three-dimensions the bubble trap portion 212 may be shaped, for example, approximately as a semi-toroid.
  • the reservoir 210 is shaped such that in order for a fluidic medium to flow from the volume 216 of the bubble trap portion 212 to the port 217, the fluidic medium must flow through the interior volume 270 of the body portion 211.
  • the reservoir 210 includes the channel 272 that leads from the interior volume 270 of the body portion 211 to the port 217, and the bubble trap portion 212 encircles at least a portion of the channel 272.
  • FIG. 10A illustrates a cross-sectional view of a system 300 in accordance with an embodiment of the present invention.
  • the system 300 includes a reservoir 310, a plunger head 320, and a plunger arm 330.
  • the reservoir 310 includes a body portion 311, a bubble trap portion 312, and a port 317.
  • the reservoir 310 has an outer surface 313 and an inner surface 314.
  • the inner surface 314 of the reservoir 310 defines a hollow interior of the reservoir 310, and the hollow interior of the reservoir 310 is able to contain a fluidic medium.
  • the port 317 of the reservoir 310 allows for the fluidic medium to be filled into or expelled from the hollow interior of the reservoir 310.
  • the body portion 311 of the reservoir 310 may have any suitable shape, such as but not limited to, a cylinder shape, a tube shape, a barrel shape, a spherical shape, a shape with a rectangular cross-section, or the like.
  • the plunger head 320 is located within the reservoir 310, and is moveable in an axial direction of the reservoir 310, to expand or contract a volume of the reservoir 310 in which a fluidic medium may be contained.
  • the plunger head 320 is connected to the plunger arm 330, such that movement of the plunger arm 330 in the axial direction of the reservoir 310 causes movement of the plunger head 320 in the axial direction of the reservoir 310.
  • the plunger head 320 includes a plunger body portion 321 and a plunger protruding portion 322.
  • the plunger head 320 further includes one or more O-rings 325 that surround a portion of the plunger body portion 321.
  • the bubble trap portion 312 of the reservoir 310 is shaped so as to form a volume 316 within an interior of the reservoir 310, such that air bubbles in a fluidic medium may be trapped in the volume 316 of the bubble trap portion 312 when the fluidic medium is expelled from the reservoir 310 through the port 317.
  • an interior surface of the bubble trap portion 312 is angled at a substantially straight angle near the port 317, so as to define the volume 316.
  • the bubble trap portion 312 extends from the body portion 311 of the reservoir 310 past a point 318 of the reservoir 310 where a fluidic medium from an interior volume of the body portion 311 is able to move into an area or channel 372 of the reservoir 310 that leads to the port 317.
  • the reservoir 310 is shaped such that as the plunger head 320 is advanced within the reservoir 310, a fluidic medium is able to pass through the port 317 while air bubbles in the reservoir 310 collect in the volume 316 defined by a substantially straight angled surface of the bubble trap portion 312 of the reservoir 310.
  • a geometry of the reservoir 310 may allow for decreasing an amount of air bubbles that are delivered with a fluidic medium as compared with traditional reservoir geometries.
  • the bubble trap portion 312 of the reservoir 310 is angled outward from an interior region of the reservoir 310 defined by the body portion 311, and a fluidic medium is able to pass directly from the interior region of the reservoir 310 defined by the body portion 311 to the port 317.
  • a surface 315 of the bubble trap portion 312 of the reservoir 310 includes a surface finish or material such that air bubbles substantially do no stick to the surface 315 and are shunted away from the port 317 toward the volume 316.
  • the plunger body portion 321 is shaped such that a contour of the plunger body portion 321 substantially matches or is substantially the same as a contour of an inner surface of the body portion 311 of the reservoir 310.
  • the plunger body portion 321 has a diameter that is slightly smaller than a diameter of the inner surface of the body portion 311 of the reservoir 310, such that the plunger head 320 is able to slide within the reservoir 310.
  • the one or more O-rings 325 on the plunger body portion 321 are in contact with the inner surface of the body portion 311 of the reservoir 310 when the plunger head 320 is within the reservoir 310.
  • the plunger protruding portion 322 is shaped such that a contour of the plunger protruding portion 322 substantially matches or is substantially the same as an inner contour of the bubble trap portion 312 of the reservoir 310. In some embodiments, the plunger protruding portion 322 is angled from the plunger body portion 321 at a substantially straight angle and protrudes from the plunger body portion 321.
  • the plunger protruding portion 322 has a size that is slightly smaller than a region defined by the inner surface of the bubble trap portion 312 of the reservoir 310, such that the plunger protruding portion 322 is able to slide within the volume 316 of the bubble trap portion 312, and such that a space for a dead volume of air is left when the plunger head 320 is fully advanced within the reservoir 310.
  • the geometry of the reservoir 310 and the plunger head 320 allow for capturing air bubbles in a volume 316 of the bubble trap portion 312 when a fluidic medium is being expelled from the port 317 of the reservoir 310.
  • the plunger protruding portion 322 has a size such that when the plunger head 320 is fully advanced within the reservoir 310, the plunger protruding portion 322 fills at least 80% of the volume 316 of the bubble trap portion 312. Also, in various embodiments, the plunger protruding portion 322 fills less than 98% of the volume 316 of the bubble trap portion 312 when the plunger head 320 is fully advanced within the reservoir 310, so that one or more air pockets for holding air exist between the plunger protruding portion 322 and an inner surface of the bubble trap portion 312 when the plunger head 320 is fully advanced within the reservoir 310. In some embodiments, the plunger protruding portion 322 extends at least partially into the volume 316 of the bubble trap portion 312 when the plunger head 320 is sufficiently advanced within the reservoir 310.
  • FIG. 10B illustrates a cross-sectional view of the reservoir 310 in accordance with an embodiment of the present invention.
  • FIG. 10B is shaded to highlight various features of the reservoir 310.
  • the reservoir 310 includes the body portion 311, the bubble trap portion 312, and the port 317.
  • the body portion 311 has an interior volume 370 for containing a fluidic medium.
  • the port 317 is in fluid flow communication with the interior volume 370 of the body portion 311.
  • the bubble trap portion 312 has the volume 316 in fluid flow communication with the interior volume 370 of the body portion 311 for trapping air bubbles that are in the fluidic medium as the fluidic medium is being expelled from the interior volume 370.
  • the port 317 is located to a particular side of the interior volume 370
  • the bubble trap portion 312 is located to the particular side of the interior volume 370.
  • the bubble trap portion 312 has a first portion 381 that extends from the body portion 311 away from the interior volume 370, and a second portion 382 that returns back toward the interior volume 370.
  • the body portion 311 and the bubble trap portion 312 are formed together as a single seamless unit.
  • the first portion 381 of the bubble trap portion 312 extends from the body portion 311 away from the interior volume 370 and the second portion 382 of the bubble trap portion 312 extends from the first portion 381 toward the interior volume 370.
  • the reservoir 310 is shaped such that in order for a fluidic medium to flow from the volume 316 of the bubble trap portion 312 to the port 317, the fluidic medium must flow through the interior volume 370 of the body portion 311.
  • the reservoir 310 includes the channel 372 that leads from the interior volume 370 of the body portion 311 to the port 317, and the bubble trap portion 312 encircles at least a portion of the channel 372.
  • the bubble trap portion 312 includes a first surface 383 that defines an edge of the volume 316 of the bubble trap portion 312, and a second surface 384 that defines another edge of the volume 316 of the bubble trap portion 312, where the second surface 384 is positioned at an angle with respect to the first surface 383. In some embodiments, the angle between the first surface 383 and the second surface 384 is less than 90 degrees. Also, in some embodiments, the first surface 383 is planar with respect to an inner surface of the body portion 311 of the reservoir 310. In various embodiments, the port 317 is located to a particular side of the interior volume 370 and the first portion 381 of the bubble trap portion 312 extends from the body portion 311 to the particular side.
  • FIG. 11A illustrates a cross-sectional view of a system 400 in accordance with an embodiment of the present invention.
  • the system 400 includes a reservoir 410, a plunger head 420, and a plunger arm 430.
  • the reservoir 410 includes a body portion 411, a bubble trap portion 412, and a port 417.
  • the reservoir 410 has an outer surface 413 and an inner surface 414.
  • the inner surface 414 of the reservoir 410 defines a hollow interior of the reservoir 410, and the hollow interior of the reservoir 410 is able to contain a fluidic medium.
  • the port 417 of the reservoir 410 allows for the fluidic medium to be filled into or expelled from the hollow interior of the reservoir 410.
  • the body portion 411 of the reservoir 410 may have any suitable shape, such as but not limited to, a cylinder shape, a tube shape, a barrel shape, a spherical shape, a shape with a rectangular cross-section, or the like.
  • the plunger head 420 is located within the reservoir 410, and is moveable in an axial direction of the reservoir 410, to expand or contract a volume of the reservoir 410 in which a fluidic medium may be contained.
  • the plunger head 420 is connected to the plunger arm 430, such that movement of the plunger arm 430 in the axial direction of the reservoir 410 causes movement of the plunger head 420 in the axial direction of the reservoir 410.
  • the plunger head 420 includes a plunger body portion 421 and a plunger protruding portion 422.
  • the plunger head 420 further includes one or more O-rings 425 that surround a portion of the plunger body portion 421.
  • the bubble trap portion 412 of the reservoir 410 is shaped so as to form a volume 416 within an interior of the reservoir 410, such that air bubbles in a fluidic medium may be trapped in the volume 416 of the bubble trap portion 412 when the fluidic medium is expelled from the reservoir 410 through the port 417.
  • the reservoir 410 is shaped such that as the plunger head 420 is advanced within the reservoir 410, a fluidic medium is able to pass through the port 417 while air bubbles in the reservoir 410 collect in the volume 416 of the reservoir 410.
  • Such a geometry of the reservoir 410 may allow for decreasing an amount of air bubbles that are delivered with a fluidic medium as compared with traditional reservoir geometries.
  • the plunger body portion 421 is shaped such that a contour of an outer surface of the plunger body portion 421 substantially matches or is substantially the same as a contour of an inner surface of the body portion 411 of the reservoir 410.
  • the plunger body portion 421 has a diameter that is slightly smaller than a diameter of the inner surface of the body portion 411 of the reservoir 410, such that the plunger head 420 is able to slide within the reservoir 410.
  • the one or more O-rings 425 on the plunger body portion 421 are in contact with the inner surface of the body portion 411 of the reservoir 410 when the plunger head 420 is within the reservoir 410.
  • the plunger protruding portion 422 is shaped such that a contour of an outer surface of the plunger protruding portion 422 substantially matches or is substantially the same as a contour of an inner surface of the bubble trap portion 412 of the reservoir 410.
  • FIG. 11B illustrates a cross-sectional view of the reservoir 410 in accordance with an embodiment of the present invention.
  • FIG. 11B is shaded to highlight various features of the reservoir 410.
  • the reservoir 410 includes the body portion 411, the bubble trap portion 412, and the port 417.
  • the body portion 411 has an interior volume 470 for containing a fluidic medium.
  • the port 417 is in fluid flow communication with the interior volume 470 of the body portion 411.
  • the bubble trap portion 412 has the volume 416 in fluid flow communication with the interior volume 470 of the body portion 411 for trapping air bubbles that are in the fluidic medium as the fluidic medium is being expelled from the interior volume 470.
  • the port 417 is located to a particular side of the interior volume 470
  • the bubble trap portion 412 is located to the particular side of the interior volume 470.
  • the bubble trap portion 412 has a first portion 481 that extends from the body portion 411 away from the interior volume 470, and a second portion 482 that returns back toward the interior volume 470.
  • the body portion 411 and the bubble trap portion 412 are formed together as a single seamless unit.
  • the first portion 481 of the bubble trap portion 412 extends from the body portion 411 away from the interior volume 470 and the second portion 482 of the bubble trap portion 412 extends from the first portion 481 toward the interior volume 470.
  • the bubble trap portion 412 includes a curved surface 483. In some embodiments, the curved surface 483 of the bubble trap portion 412 is in contact with the fluidic medium when the fluidic medium is in the volume 416 of the bubble trap portion 412. In various embodiments, the reservoir 410 is shaped such that in order for a fluidic medium to flow from the volume 416 of the bubble trap portion 412 to the port 417, the fluidic medium must flow through the interior volume 470 of the body portion 411. In some embodiments, the reservoir 410 includes a channel 472 that leads from the interior volume 470 of the body portion 411 to the port 417, and the bubble trap portion 412 encircles at least a portion of the channel 472.
  • the plunger protruding portion 422 is shaped such that a contour of the plunger protruding portion 422 substantially matches or is substantially the same as an inner contour of the bubble trap portion 412 of the reservoir 410.
  • the plunger protruding portion 422 is at least partially curved and protrudes from the plunger body portion 421.
  • the plunger protruding porting includes a surface that is substantially parallel to an inner surface of the body portion 411 of the reservoir 410.
  • the plunger protruding portion 422 has a size that is slightly smaller than a region defined by the inner surface of the bubble trap portion 412 of the reservoir 410, such that the plunger protruding portion 422 is able to slide within the volume 416 of the reservoir 410, and such that a space for a dead volume of air is left when the plunger head 420 is fully advanced within the reservoir 410.
  • the geometry of the reservoir 410 and the plunger head 420 allow for capturing air bubbles in a volume 416 of the bubble trap portion 412 when a fluidic medium is being expelled from the port 417 of the reservoir 410.
  • the plunger protruding portion 422 has a size such that when the plunger head 420 is fully advanced within the reservoir 410, the plunger protruding portion 422 fills at least 80% of the volume 416 of the bubble trap portion 412. Also, in various embodiments, the plunger protruding portion 422 fills less than 98% of the volume 416 of the bubble trap portion 412 when the plunger head 420 is fully advanced within the reservoir 410, so that one or more air pockets for holding air exist between the plunger protruding portion 422 and an inner surface of the bubble trap portion 412 when the plunger head 420 is fully advanced within the reservoir 410. In some embodiments, the plunger protruding portion 422 extends at least partially into the volume 416 of the bubble trap portion 412 when the plunger head 420 is sufficiently advanced within the reservoir 410.
  • FIG. 12A illustrates a cross-sectional view of a system 500 in accordance with an embodiment of the present invention.
  • the system 500 includes a reservoir 510, a plunger head 520, and a plunger arm 530.
  • the system 500 further includes a needle 550.
  • the reservoir 510 is similar to the reservoir 210 of the system 200 (refer to FIG. 9A ), and includes a body portion 511 and a bubble trap portion 512.
  • the bubble trap portion 512 defines a volume 516 for trapping air bubbles.
  • the reservoir 510 has an air trap geometry that allows for capturing air bubbles.
  • the plunger head 520 is similar to the plunger head 220 of the system 200 (refer to FIG. 9A ).
  • the plunger head 520 includes a plunger body portion 521 and a plunger protruding portion 522.
  • the plunger head 520 further includes a depression or relief 523 for allowing at least a portion of the needle 550 to be inserted into an interior of the reservoir 510 when the plunger head 520 is fully advanced within the reservoir 510.
  • the plunger head 520 has the relief 523 for receiving at least a portion of the needle 550 when the plunger head 520 is sufficiently advanced within the reservoir 510 and the portion of the needle 550 is inserted into the reservoir 510.
  • the reservoir 510 is shaped to trap air bubbles.
  • the reservoir 510 and the plunger head 520 are shaped so as to minimize a delivery of air bubbles when a fluidic medium is expelled from the reservoir 510.
  • FIG. 12B illustrates a cross-sectional view of the reservoir 510 in accordance with an embodiment of the present invention.
  • FIG. 12B is shaded to highlight various features of the reservoir 510.
  • the reservoir 510 includes the body portion 511, the bubble trap portion 512, and a port 517.
  • the body portion 511 has an interior volume 570 for containing a fluidic medium.
  • the port 517 is in fluid flow communication with the interior volume 570 of the body portion 511.
  • the bubble trap portion 512 has the volume 516 in fluid flow communication with the interior volume 570 of the body portion 511 for trapping air bubbles that are in the fluidic medium as the fluidic medium is being expelled from the interior volume 570.
  • the port 517 is located to a particular side of the interior volume 570
  • the bubble trap portion 512 is located to the particular side of the interior volume 570.
  • the bubble trap portion 512 has a first portion 581 that extends from the body portion 511 away from the interior volume 570, and a second portion 582 that returns back toward the interior volume 570.
  • the body portion 511 and the bubble trap portion 512 are formed together as a single seamless unit.
  • the first portion 581 of the bubble trap portion 512 extends from the body portion 511 away from the interior volume 570 and the second portion 582 of the bubble trap portion 512 extends from the first portion 581 toward the interior volume 570.
  • the bubble trap portion 512 includes a curved surface 583 having a first end region 584, a second end region 585, and a middle region 586 between the first end region 584 and the second end region 585.
  • the first end region 584 and the second end region 585 are closer to the interior volume 570 of the body portion 511 than the middle region 586 is to the interior volume 570.
  • the first end region 584 is in contact with the body portion 511, and the second end region 585 is located adjacent to the interior volume 570 of the body portion 511.
  • the curved surface 583 of the bubble trap portion 512 is in contact with the fluidic medium when the fluidic medium is in the volume 516 of the bubble trap portion 512. In further embodiments, the curved surface 583 is approximately U-shaped. FIG. 9B illustrates a cross-sectional view, but in three-dimensions the bubble trap portion 512 may be shaped, for example, approximately as a semi-toroid.
  • the reservoir 510 is shaped such that in order for a fluidic medium to flow from the volume 516 of the bubble trap portion 512 to the port 517, the fluidic medium must flow through the interior volume 570 of the body portion 511.
  • the reservoir 510 includes a channel 572 that leads from the interior volume 570 of the body portion 511 to the port 517, and the bubble trap portion 512 encircles at least a portion of the channel 572.
  • FIG. 12C illustrates a cross-sectional view of the system 500 of FIG. 12A in accordance with another embodiment of the present invention.
  • the system 500 further includes a plug 560.
  • the plug 560 is located between an interior surface 515 of the bubble trap portion 512 of the reservoir 510 and a location of the reservoir where a fluidic medium is able to be expelled from the reservoir.
  • the plug 560 may comprise, for example, a hydrophilic material or a hydrophobic material, that will substantially keep air bubbles from being dispensed through a port 517 of the reservoir 510.
  • the plug 560 shunts air bubbles in a fluidic medium away from the port 517 of the reservoir 510 and toward the volume 516 of the bubble trap portion 512 when the fluidic medium is being expelled from an interior volume of the body portion 511 of the reservoir 510.

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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (11)

  1. Un dispositif d'administration de milieu de perfusion (200), comprenant :
    un réservoir (210) comprenant :
    une partie de corps (211) ayant un volume intérieur pour contenir un milieu fluidique ;
    un orifice (217) en communication d'écoulement de fluide avec le volume intérieur ;
    une partie de débulleur (212) ayant une surface intérieure étant courbée ou inclinée près de l'orifice (217) de façon à définir un volume (216) étant en communication d'écoulement de fluide avec le volume intérieur conçu pour piéger des bulles d'air qui se trouvent dans le milieu fluidique à mesure que le milieu fluidique est expulsé à partir du volume intérieur ; et
    un canal (272) qui conduit du volume intérieur à l'orifice (217) ;
    une tête de piston (220) située à l'intérieur du réservoir (210) et mobile dans une direction axiale du réservoir (210) pour dilater ou contracter un volume du réservoir (210) ;
    dans lequel la partie de débulleur (212) encercle au moins une partie du canal (272).
  2. Dispositif selon la revendication 1, dans lequel la partie de débulleur est formée approximativement en tant que demi-tore.
  3. Dispositif selon la revendication 1, dans lequel une surface de la partie de débulleur (212) qui est en contact avec le milieu fluidique lorsque le milieu fluidique est dans le volume (216) de la partie de débulleur (212) est approximativement en forme de U.
  4. Dispositif selon la revendication 1, dans lequel la partie de débulleur (212) comprend une première surface qui définit un bord du volume de la partie de débulleur, et une seconde surface qui définit un autre bord du volume de la partie de débulleur, où la seconde surface est positionnée selon un angle par rapport à la première surface.
  5. Dispositif selon la revendication 4, dans lequel l'angle entre la première surface et la seconde surface est inférieur à 90 degrés.
  6. Dispositif selon la revendication 4, dans lequel la première surface est plane par rapport à une surface interne de la partie de corps (211).
  7. Dispositif selon la revendication 1, ladite partie de corps (211) et ladite partie de débulleur (212) ayant été formées ensemble comme une seule unité homogène.
  8. Dispositif selon la revendication 1, dans lequel ledit réservoir (210) est formé de sorte que pour que le milieu fluidique s'écoule du volume (216) de la partie de débulleur (212) vers l'orifice (217), le milieu fluidique doit circuler à travers le volume intérieur (270).
  9. Dispositif selon la revendication 1, dans lequel la tête de piston (220) a une partie de corps de piston (221) et une partie en saillie de piston (222).
  10. Dispositif selon la revendication 9, dans lequel un contour de la partie en saillie de piston (222) correspond sensiblement à un contour interne de la partie de débulleur (212).
  11. Dispositif selon la revendication 9, dans lequel la partie en saillie de piston (222) s'étend au moins partiellement dans le volume (216) de la partie de débulleur (212) lorsque la tête de piston (220) est suffisamment avancée à l'intérieur du réservoir (210).
EP07814386.4A 2007-04-30 2007-08-23 Remplissage de réservoir, gestion des bulles d'air, et systèmes et procédés d'administration de milieu de perfusion associés Active EP2146760B1 (fr)

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JP2010525868A (ja) 2010-07-29
CA2685474A1 (fr) 2008-11-13
US8083716B2 (en) 2011-12-27
US8025658B2 (en) 2011-09-27
US20090198215A1 (en) 2009-08-06
US20090198191A1 (en) 2009-08-06
CA2685474C (fr) 2014-07-08
EP2146760A2 (fr) 2010-01-27
JP5102350B2 (ja) 2012-12-19
DK2146760T3 (en) 2019-01-28
US20080269681A1 (en) 2008-10-30
WO2008136845A2 (fr) 2008-11-13
US9522225B2 (en) 2016-12-20

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