[go: up one dir, main page]

WO2008089452A3 - Procédés de modification de développement de l'infarctus du myocarde - Google Patents

Procédés de modification de développement de l'infarctus du myocarde Download PDF

Info

Publication number
WO2008089452A3
WO2008089452A3 PCT/US2008/051505 US2008051505W WO2008089452A3 WO 2008089452 A3 WO2008089452 A3 WO 2008089452A3 US 2008051505 W US2008051505 W US 2008051505W WO 2008089452 A3 WO2008089452 A3 WO 2008089452A3
Authority
WO
WIPO (PCT)
Prior art keywords
different
bioscaffolding
mixture
modifying
components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/051505
Other languages
English (en)
Other versions
WO2008089452A2 (fr
Inventor
Eugene T Michal
Shubhayu Basu
Alexander J Sheehy
Francis G Spinale
Rupak Mukherjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Cardiovascular Systems Inc
Original Assignee
Abbott Cardiovascular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Cardiovascular Systems Inc filed Critical Abbott Cardiovascular Systems Inc
Priority to JP2009546553A priority Critical patent/JP5542449B2/ja
Priority to EP08727952.7A priority patent/EP2109469B1/fr
Publication of WO2008089452A2 publication Critical patent/WO2008089452A2/fr
Anticipated expiration legal-status Critical
Publication of WO2008089452A3 publication Critical patent/WO2008089452A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)

Abstract

L'invention concerne une bioarmature qui peut être formée dans une région de post-infarctus du myocarde suffisante pour provoquer une atténuation d'une vitesse de développement de l'infarctus du myocarde. Une bioarmature peut en outre être formée dans la région de post-infarctus du myocarde afin d'entraîner une augmentation de l'épaisseur de la paroi ventriculaire gauche postérieure. Le gel ou la bioarmature peut être formé à partir d'un mélange de composants de gel de différents systèmes de gélification. A titre d'exemple, une bioarmature peut être formée en mélangeant au moins deux composants différents d'au moins deux systèmes de gélification à deux composants différents pour former un premier mélange et en mélangeant au moins deux composants différents (autres que les composants qui forment le premier mélange) des au moins deux systèmes de gélification à deux composants différents pour former un second mélange.
PCT/US2008/051505 2007-01-18 2008-01-18 Procédés de modification de développement de l'infarctus du myocarde Ceased WO2008089452A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009546553A JP5542449B2 (ja) 2007-01-18 2008-01-18 心筋梗塞進展の改変方法
EP08727952.7A EP2109469B1 (fr) 2007-01-18 2008-01-18 Procédés de modification de développement de l'infarctus du myocarde

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88559307P 2007-01-18 2007-01-18
US60/885,593 2007-01-18
US12/016,180 US9005672B2 (en) 2006-11-17 2008-01-17 Methods of modifying myocardial infarction expansion
US12/016,180 2008-01-17

Publications (2)

Publication Number Publication Date
WO2008089452A2 WO2008089452A2 (fr) 2008-07-24
WO2008089452A3 true WO2008089452A3 (fr) 2009-08-06

Family

ID=39636755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/051505 Ceased WO2008089452A2 (fr) 2007-01-18 2008-01-18 Procédés de modification de développement de l'infarctus du myocarde

Country Status (4)

Country Link
US (2) US9005672B2 (fr)
EP (2) EP2452699B1 (fr)
JP (1) JP5542449B2 (fr)
WO (1) WO2008089452A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US8383158B2 (en) * 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8377033B2 (en) 2010-09-08 2013-02-19 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
WO2015160793A1 (fr) 2014-04-14 2015-10-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Hydrogel injectable thermosensible et biodégradable pour le traitement d'une myocardiopathie ischémique
US11590162B2 (en) 2016-10-07 2023-02-28 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, antioxidant, thermally responsive injectable hydrogel and uses therefor
US20190255116A1 (en) * 2016-10-18 2019-08-22 Osaka University Kit for preparing disease-treating agent, disease-treating agent and method for preparing disease-treating agent
US11389569B2 (en) 2017-04-03 2022-07-19 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable, porous, thermally responsive injectable hydrogel as soft tissue defect filler
CN110944689B (zh) 2017-06-07 2022-12-09 施菲姆德控股有限责任公司 血管内流体运动设备、系统和使用方法
EP3710076B1 (fr) 2017-11-13 2023-12-27 Shifamed Holdings, LLC Dispositifs de déplacement de liquide intravasculaire, systèmes et procédés d'utilisation
WO2019152875A1 (fr) 2018-02-01 2019-08-08 Shifamed Holdings, Llc Pompes à sang intravasculaires et méthodes d'utilisation et procédés de fabrication
WO2020028537A1 (fr) 2018-07-31 2020-02-06 Shifamed Holdings, Llc Pompes sanguines intravasculaires et procédés d'utilisation
US12220570B2 (en) 2018-10-05 2025-02-11 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
EP3996797A4 (fr) 2019-07-12 2023-08-02 Shifamed Holdings, LLC Pompes à sang intravasculaires et méthode d'utilisation et procédé de fabrication
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
EP4010046A4 (fr) 2019-08-07 2023-08-30 Calomeni, Michael Pompes sanguines à cathéter et boîtiers de pompe pliants
WO2021062270A1 (fr) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Pompes à sang de cathéter et boîtiers de pompe pliables
WO2021062265A1 (fr) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Dispositifs et systèmes de pompes à sang intravasculaires et leurs procédés d'utilisation et de commande
WO2021062260A1 (fr) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Pompes à sang de cathéter et conduits sanguins pliables
WO2021119478A1 (fr) 2019-12-11 2021-06-17 Shifamed Holdings, Llc Pompes à sang d'aorte descendante et de veine cave

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050013A2 (fr) * 2002-11-29 2004-06-17 The Regents Of The University Of California Compositions de materiaux et systemes et procedes associes pour le traitement de conditions cardiaques
WO2004091592A2 (fr) * 2003-04-15 2004-10-28 Guidant Corporation, V.I. Procedes et compositions destines au traitement d'infarctus du myocarde
WO2006113407A2 (fr) * 2005-04-19 2006-10-26 Advanced Cardiovascular Systems, Inc. Supports biologiques a base d'hydrogels et revetements de dispositifs biomedicaux
WO2007145909A2 (fr) * 2006-06-05 2007-12-21 Abbott Cardiovascular Systems Inc. Compositions et méthodes pour traiter une lésion post-infarctus du myocarde

Family Cites Families (326)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2194144B (en) 1986-08-22 1990-04-25 American Cyanamid Co Stable pharmaceutical gel preparation
US2512569A (en) 1947-09-26 1950-06-20 Jacob A Saffir Hypodermic needle
US3144868A (en) 1960-10-21 1964-08-18 Mario E Jascalevich Drainage and feeding cannulae
US3584624A (en) 1969-02-24 1971-06-15 Vincent L De Ciutiis Flexible intravenous catheter provided with cutting tip means
US3780733A (en) 1972-07-24 1973-12-25 Manzor M Martinez Catheter
US3890976A (en) 1972-10-26 1975-06-24 Medical Products Corp Catheter tip assembly
US3804097A (en) * 1972-12-14 1974-04-16 P Rudie Method of irrigating and treating an abcess
US6436135B1 (en) 1974-10-24 2002-08-20 David Goldfarb Prosthetic vascular graft
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPS60126170A (ja) 1983-12-14 1985-07-05 テルモ株式会社 カテ−テルとその製造方法
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4617186A (en) 1984-12-28 1986-10-14 Alcon Laboratories, Inc. Sustained release drug delivery system utilizing bioadhesive polymers
JPS61205446A (ja) 1985-03-08 1986-09-11 Nippon Carbide Ind Co Ltd 人工食品組成物
US4824436A (en) 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
JPS61205446U (fr) 1985-06-14 1986-12-25
US4794931A (en) * 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
US5026350A (en) 1986-10-09 1991-06-25 Hakko Electric Machine Works Co., Ltd. Set of double needles for injecting liquid medicine
CH673117A5 (fr) * 1986-12-10 1990-02-15 Ajinomoto Kk
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
FR2627984B1 (fr) 1988-03-03 1990-08-17 Sanofi Sa Composition pulverulente a base d'alginate pour empreintes dentaires
US5588432A (en) 1988-03-21 1996-12-31 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials, and ablating tissue
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
US4869717A (en) 1988-04-25 1989-09-26 Adair Edwin Lloyd Gas insufflation needle with instrument port
US5116317A (en) * 1988-06-16 1992-05-26 Optimed Technologies, Inc. Angioplasty catheter with integral fiber optic assembly
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
AU4191989A (en) 1988-08-24 1990-03-23 Marvin J. Slepian Biodegradable polymeric endoluminal sealing
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5634946A (en) * 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US5092848A (en) * 1988-10-13 1992-03-03 Deciutiis Vincent L Intravenous catheter with built-in cutting tip and method for making the same
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
JPH0662678B2 (ja) 1988-11-28 1994-08-17 電気化学工業株式会社 ヒアルロン酸固定化蛋白質及びその製造方法
US5049130A (en) 1988-12-23 1991-09-17 Cardiovascular Imaging Systems, Inc. System and method for pressure filling of catheters
DE3908183C5 (de) * 1989-03-14 2005-01-05 Kiekert Ag Kraftfahrzeug-Türverschluß
US5109859A (en) * 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
US5024234A (en) 1989-10-17 1991-06-18 Cardiovascular Imaging Systems, Inc. Ultrasonic imaging catheter with guidewire channel
US5485486A (en) * 1989-11-07 1996-01-16 Qualcomm Incorporated Method and apparatus for controlling transmission power in a CDMA cellular mobile telephone system
WO1991007154A1 (fr) 1989-11-13 1991-05-30 President And Fellows Of Harvard College REGULATION EXTRALUMINALE DE LA CROISSANCE ET DE LA REPARATION DE STRUCTURES TUBULAIRES ιIN VIVO
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5811533A (en) 1990-06-11 1998-09-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
FR2668698B1 (fr) 1990-11-06 1997-06-06 Ethnor Instrument chirurgical formant trocart.
US5202745A (en) * 1990-11-07 1993-04-13 Hewlett-Packard Company Polarization independent optical coherence-domain reflectometry
DK0561903T3 (da) 1990-12-10 1995-08-21 Howmedica Et middel og en fremgangsmåde til interstitiel laserenergiindføring
ATE157269T1 (de) * 1990-12-17 1997-09-15 Cardiovascular Imaging Systems Vaskularer katheter mit einem ein niedriges profil aufweisenden distalen ende
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5465147A (en) 1991-04-29 1995-11-07 Massachusetts Institute Of Technology Method and apparatus for acquiring images using a ccd detector array and no transverse scanner
DE69227902T3 (de) 1991-04-29 2010-04-22 Massachusetts Institute Of Technology, Cambridge Vorrichtung für optische abbildung und messung
US6134003A (en) 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
SE9101853D0 (sv) * 1991-06-17 1991-06-17 Jonas Wadstroem Improved tissue ashesive
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5291267A (en) * 1992-01-22 1994-03-01 Hewlett-Packard Company Optical low-coherence reflectometry using optical amplification
JPH06507106A (ja) 1992-02-10 1994-08-11 アドヴァンスト・カーディオヴァスキュラー・システムズ・インコーポレイテッド カテーテル使用のための平滑表面を有する複合材料
DE69333482T2 (de) 1992-02-21 2005-03-24 Boston Scientific Ltd., Barbados Katheter zur Bilderzeugung mittels Ultraschall
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
MX9301823A (es) 1992-03-30 1994-01-31 Alza Corp Composicion para el suministro de liberacion controlado de un agente biologicamente activo.
US5306250A (en) * 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
JP3063935B2 (ja) 1992-05-12 2000-07-12 宇部興産株式会社 接着性、耐熱性および耐カ−ル性を兼ね備えたポリイミドシロキサン組成物
US5336252A (en) 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
US5365325A (en) 1992-08-10 1994-11-15 Hitachi, Ltd. Method of multi-color recording using electro-photography process and apparatus therefor wherein mixed colors generation is prevented
US5672153A (en) 1992-08-12 1997-09-30 Vidamed, Inc. Medical probe device and method
DE4235506A1 (de) 1992-10-21 1994-04-28 Bavaria Med Tech Katheter zur Injektion von Arzneimitteln
US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6689608B1 (en) * 1993-02-01 2004-02-10 Massachusetts Institute Of Technology Porous biodegradable polymeric materials for cell transplantation
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
EP2025353A2 (fr) 1993-04-30 2009-02-18 Massachusetts Institute of Technology Compositions de cellules de polysaccharide injectables
US5437632A (en) 1993-06-02 1995-08-01 Target Therapeutics, Inc. Variable stiffness balloon catheter
US5725551A (en) * 1993-07-26 1998-03-10 Myers; Gene Method and apparatus for arteriotomy closure
IS4223A (is) 1993-11-03 1995-05-04 Astra Ab Tæki til að nota við blöndun lyfjablöndu saman við annað efni
US5527322A (en) * 1993-11-08 1996-06-18 Perclose, Inc. Device and method for suturing of internal puncture sites
JP2833456B2 (ja) * 1993-11-22 1998-12-09 株式会社東芝 体内挿入型超音波検査装置
US5380292A (en) * 1993-12-22 1995-01-10 Wilson-Cook Medical, Inc. Gastrointestinal needle mechanism
US5795331A (en) 1994-01-24 1998-08-18 Micro Therapeutics, Inc. Balloon catheter for occluding aneurysms of branch vessels
FR2715855A1 (fr) 1994-02-10 1995-08-11 Floch Serge Protège-seringue pour radioéléments émetteurs béta.
JP3591837B2 (ja) 1994-02-17 2004-11-24 ニューヨーク・ブラッド・センター・インコーポレイテッド フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用
US6334872B1 (en) * 1994-02-18 2002-01-01 Organogenesis Inc. Method for treating diseased or damaged organs
DE4408108A1 (de) * 1994-03-10 1995-09-14 Bavaria Med Tech Katheter zur Injektion eines Fluid bzw. eines Arneimittelns
US5464395A (en) 1994-04-05 1995-11-07 Faxon; David P. Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway
DE69535752D1 (de) 1994-04-13 2008-06-26 Biotransplant Inc Alpha(1,3)galactosyltransferase-negatives schwein
ATE219343T1 (de) 1994-04-29 2002-07-15 Scimed Life Systems Inc Stent mit kollagen
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US5621610A (en) * 1994-06-30 1997-04-15 Compaq Computer Corporation Collapsible computer keyboard structure with associated collapsible pointing stick
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
IL110367A (en) * 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
US6152141A (en) 1994-07-28 2000-11-28 Heartport, Inc. Method for delivery of therapeutic agents to the heart
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5740808A (en) * 1996-10-28 1998-04-21 Ep Technologies, Inc Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
WO1996011671A1 (fr) * 1994-10-12 1996-04-25 Focal, Inc. Administration ciblee au moyen de polymeres biodegradables
US6099864A (en) 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
FR2727692A1 (fr) * 1994-12-05 1996-06-07 Europ Propulsion Dispositif d'extraction de gaz pour four d'infiltration ou depot chimique en phase vapeur dans une installation de fabrication de pieces en materiau composite
US5810885A (en) 1994-12-28 1998-09-22 Omrix Biopharm Sa Device for applying one or several fluids
US5919570A (en) 1995-02-01 1999-07-06 Schneider Inc. Slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly(N-vinylpyrrolidone) polymer hydrogel, coated polymer and metal substrate materials, and coated medical devices
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5869127A (en) 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
US5580714A (en) 1995-03-08 1996-12-03 Celox Laboratories, Inc. Cryopreservation solution
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5669883A (en) 1995-04-12 1997-09-23 Symbiosis Corporation Veress needle and cannula assembly
US6251104B1 (en) 1995-05-10 2001-06-26 Eclipse Surgical Technologies, Inc. Guiding catheter system for ablating heart tissue
US5919449A (en) 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US5900433A (en) 1995-06-23 1999-05-04 Cormedics Corp. Vascular treatment method and apparatus
US6102904A (en) 1995-07-10 2000-08-15 Interventional Technologies, Inc. Device for injecting fluid into a wall of a blood vessel
US5693029A (en) 1995-07-10 1997-12-02 World Medical Manufacturing Corporation Pro-cell intra-cavity therapeutic agent delivery device
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
AU7254896A (en) 1995-10-05 1997-04-28 Genentech Inc. Improved angiogenesis using hepatocyte growth factor
US6726677B1 (en) * 1995-10-13 2004-04-27 Transvascular, Inc. Stabilized tissue penetrating catheters
IL124038A (en) * 1995-10-13 2004-02-19 Transvascular Inc Apparatus for bypassing arterial obstructions and/or performing other transvascular procedures
US5642234A (en) 1995-10-30 1997-06-24 Lumatec Industries, Inc. Illuminated magnifying lens assembly
US6482231B1 (en) 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
US6458889B1 (en) * 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
EP1704878B1 (fr) 1995-12-18 2013-04-10 AngioDevice International GmbH Compositions de polyméres réticulés et leur procédé d'utilisation
US5941868A (en) 1995-12-22 1999-08-24 Localmed, Inc. Localized intravascular delivery of growth factors for promotion of angiogenesis
US6632436B2 (en) 1996-01-25 2003-10-14 Genitrix Llc Vaccine compositions and method of modulating immune responses
AU715822B2 (en) 1996-03-15 2000-02-10 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue adhesive suitable for spray application
AU737078C (en) 1996-05-24 2002-05-02 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
EP0907721A1 (fr) 1996-05-28 1999-04-14 Brown University Research Foundation Charpentes biodegradables a base de hyaluronan destinees a la reparation tissulaire
US5785689A (en) 1996-07-18 1998-07-28 Act Medical, Inc. Endoscopic catheter sheath position control
US5655548A (en) 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5957941A (en) 1996-09-27 1999-09-28 Boston Scientific Corporation Catheter system and drive assembly thereof
US5827313A (en) 1996-09-27 1998-10-27 Boston Scientific Corporation Device for controlled longitudinal movement of an operative element within a catheter sheath and method
US5722403A (en) * 1996-10-28 1998-03-03 Ep Technologies, Inc. Systems and methods using a porous electrode for ablating and visualizing interior tissue regions
US5980887A (en) 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
EP0842640A1 (fr) 1996-11-13 1998-05-20 Sulzer Osypka GmbH Cathéter cardiaque avec électrode positionnée sur un élément extensible
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6102926A (en) 1996-12-02 2000-08-15 Angiotrax, Inc. Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use
US6120520A (en) 1997-05-27 2000-09-19 Angiotrax, Inc. Apparatus and methods for stimulating revascularization and/or tissue growth
US5730732A (en) * 1996-12-04 1998-03-24 Ethicon, Inc. Non-magnetic stainless steel surgical needle
GB9700624D0 (en) 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
US5935160A (en) 1997-01-24 1999-08-10 Cardiac Pacemakers, Inc. Left ventricular access lead for heart failure pacing
JP3134287B2 (ja) 1997-01-30 2001-02-13 株式会社ニッショー 心腔内縫合手術用カテーテル組立体
US5980551A (en) 1997-02-07 1999-11-09 Endovasc Ltd., Inc. Composition and method for making a biodegradable drug delivery stent
JP4116683B2 (ja) 1997-02-28 2008-07-09 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 徐放性局所送達製剤
US5968064A (en) 1997-02-28 1999-10-19 Lumend, Inc. Catheter system for treating a vascular occlusion
US6045565A (en) * 1997-11-04 2000-04-04 Scimed Life Systems, Inc. Percutaneous myocardial revascularization growth factor mediums and method
US6093177A (en) 1997-03-07 2000-07-25 Cardiogenesis Corporation Catheter with flexible intermediate section
US6443949B2 (en) 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6086582A (en) * 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
WO1998043555A1 (fr) * 1997-04-03 1998-10-08 Point Biomedical Corporation Systeme intravesical de liberation de medicaments
US5984908A (en) 1997-04-10 1999-11-16 Chase Medical Inc Venous return catheter having integral support member
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
CA2240757C (fr) 1997-07-14 2001-08-28 Matsushita Electric Industrial Co., Ltd. Dispositif de ponction de vaisseau sanguin
DE19734220C2 (de) 1997-08-07 2000-01-13 Pulsion Verwaltungs Gmbh & Co Kathetersystem mit einem Einführungsdraht
EP1009317A4 (fr) 1997-08-28 2001-01-24 Boston Scient Corp Systeme d'implantation d'une fibre de polysaccharide reticulee et procedes de formation et d'insertion de cette fibre
WO1999011287A1 (fr) * 1997-09-04 1999-03-11 Osiris Therapeutics, Inc. Ligands modulant la differenciation des cellules mesenchymateuses souches
US6050949A (en) * 1997-09-22 2000-04-18 Scimed Life Systems, Inc. Catheher system having connectable distal and proximal portions
US6183444B1 (en) * 1998-05-16 2001-02-06 Microheart, Inc. Drug delivery module
US6179809B1 (en) * 1997-09-24 2001-01-30 Eclipse Surgical Technologies, Inc. Drug delivery catheter with tip alignment
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
US6371935B1 (en) * 1999-01-22 2002-04-16 Cardeon Corporation Aortic catheter with flow divider and methods for preventing cerebral embolization
WO1999017784A1 (fr) 1997-10-07 1999-04-15 Regents Of The University Of California Corporation Traitement de la vasculopathie peripherique obliterante et de la coronarite au moyen de conbinaisons d'heparine et d'un agoniste a2 adenosine, ou au moyen d'adenosine
IL122153A (en) 1997-11-10 2005-03-20 Alomone Labs Ltd Biocompatible polymeric coating material
US6146373A (en) 1997-10-17 2000-11-14 Micro Therapeutics, Inc. Catheter system and method for injection of a liquid embolic composition and a solidification agent
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
US6749617B1 (en) 1997-11-04 2004-06-15 Scimed Life Systems, Inc. Catheter and implants for the delivery of therapeutic agents to tissues
US6151525A (en) 1997-11-07 2000-11-21 Medtronic, Inc. Method and system for myocardial identifier repair
WO2003064637A1 (fr) 2001-11-06 2003-08-07 Medtronic, Inc. Methode et systeme permettant de reparer un infarctus du myocarde
US6183432B1 (en) * 1997-11-13 2001-02-06 Lumend, Inc. Guidewire and catheter with rotating and reciprocating symmetrical or asymmetrical distal tip
US6197324B1 (en) * 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6371992B1 (en) * 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
US6217527B1 (en) * 1998-09-30 2001-04-17 Lumend, Inc. Methods and apparatus for crossing vascular occlusions
US6231546B1 (en) 1998-01-13 2001-05-15 Lumend, Inc. Methods and apparatus for crossing total occlusions in blood vessels
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6187330B1 (en) * 1998-01-30 2001-02-13 Scios Inc. Controlled release delivery of peptide or protein
DE69838526T2 (de) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Gerät zum Freisetzen eines Medikaments im Herzen
EP0938871A3 (fr) 1998-02-27 2001-03-07 ECLIPSE SURGICAL TECHNOLOGIES, Inc. Dispositif de chirurgie
US6201608B1 (en) * 1998-03-13 2001-03-13 Optical Biopsy Technologies, Inc. Method and apparatus for measuring optical reflectivity and imaging through a scattering medium
US6175669B1 (en) * 1998-03-30 2001-01-16 The Regents Of The Universtiy Of California Optical coherence domain reflectometry guidewire
IL138666A0 (en) * 1998-03-31 2001-10-31 Transvascular Inc Catheters, systems and methods for percutaneous in situ arterio-venous bypass
US5979449A (en) 1998-04-09 1999-11-09 Steer; Eugene Lyle Oral appliance device and method for use thereof for appetite suppression
JP2002512200A (ja) 1998-04-17 2002-04-23 アンジオジェニックス， インコーポレイテッド 治療的な脈管形成因子およびその使用方法
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
ATE358456T1 (de) * 1998-05-05 2007-04-15 Boston Scient Ltd Stent mit glatten enden
US6447504B1 (en) 1998-07-02 2002-09-10 Biosense, Inc. System for treatment of heart tissue using viability map
US6613070B2 (en) * 1998-08-04 2003-09-02 Baxter International Inc. System and method for sealing vascular penetrations with hemostatic gels
US6102887A (en) * 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
CA2339330A1 (fr) * 1998-08-13 2000-02-24 University Of Southern California Procede pour augmenter le debit sanguin vers le tissu ischemique
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6191144B1 (en) * 1998-08-17 2001-02-20 Warner-Lambert Company Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis
CA2340652C (fr) 1998-08-20 2013-09-24 Cook Incorporated Dispositif medical implantable dote d'un revetement et comprenant du paclitaxel
JP2002524425A (ja) 1998-09-04 2002-08-06 サイオス インコーポレイテッド 増殖因子の徐放性投与のためのヒドロゲル組成物
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US6044298A (en) 1998-10-13 2000-03-28 Cardiac Pacemakers, Inc. Optimization of pacing parameters based on measurement of integrated acoustic noise
US6162202A (en) 1998-10-26 2000-12-19 Sicurelli; Robert Flexible syringe needle
CA2349168C (fr) 1998-11-10 2009-01-06 Denki Kagaku Kogyo Kabushiki Kaisha Gel d'acide hyaluronique, procede de fabrication et materiel medical le contenant
US6761887B1 (en) 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
DE19855890A1 (de) 1998-12-03 2000-06-08 Nerlich Michael Poröse Kompositmatrix, deren Herstellung und Verwendung
KR20010040761A (ko) 1998-12-09 2001-05-15 쿡 인코포레이티드 중공의 만곡형 초탄성 의료용 니들
US6193763B1 (en) * 1998-12-17 2001-02-27 Robert A. Mackin Apparatus and method for contemporaneous treatment and fluoroscopic mapping of body tissue
US6328229B1 (en) 1998-12-18 2001-12-11 Cohesion Technologies, Inc. Low volume mixing spray head for mixing and dispensing of two reactive fluid components
US6338717B1 (en) * 1998-12-22 2002-01-15 Asahi Kogaku Kogyo Kabushiki Kaisha Tip of ultrasonic endoscope
US6210392B1 (en) * 1999-01-15 2001-04-03 Interventional Technologies, Inc. Method for treating a wall of a blood vessel
WO2000041732A1 (fr) 1999-01-19 2000-07-20 The Children's Hospital Of Philadelphia Compositions hydrogel pour l'administration controlee de vecteurs viraux, et leurs procedes d'utilisation
US6217554B1 (en) * 1999-02-12 2001-04-17 Pharmaspec Corporation Methods and apparatus for delivering substances into extravascular tissue
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US6296602B1 (en) 1999-03-17 2001-10-02 Transfusion Technologies Corporation Method for collecting platelets and other blood components from whole blood
JP3678602B2 (ja) 1999-03-17 2005-08-03 住友ベークライト株式会社 シリンジ固定注入装置
US6432119B1 (en) 1999-03-17 2002-08-13 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6192271B1 (en) * 1999-04-20 2001-02-20 Michael Hayman Radiotherapy stent
US6858229B1 (en) * 1999-04-26 2005-02-22 California Institute Of Technology In situ forming hydrogels
US6159443A (en) 1999-04-29 2000-12-12 Vanderbilt University X-ray guided drug delivery
JP3063935U (ja) 1999-05-17 1999-12-10 川澄化学工業株式会社 二液同時混合注出器及びプランジャ結合部材
EP1180050B1 (fr) 1999-05-21 2015-07-08 Covidien LP Aiguille interfacielle pour creer une interface arrondie entre des liquides distribues
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6494862B1 (en) 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US7815590B2 (en) 1999-08-05 2010-10-19 Broncus Technologies, Inc. Devices for maintaining patency of surgically created channels in tissue
US6709427B1 (en) 1999-08-05 2004-03-23 Kensey Nash Corporation Systems and methods for delivering agents into targeted tissue of a living being
US7288096B2 (en) 2003-01-17 2007-10-30 Origin Medsystems, Inc. Apparatus for placement of cardiac defibrillator and pacer
WO2001016210A1 (fr) 1999-08-27 2001-03-08 Cohesion Technologies, Inc. Compositions formant des reseaux de polymeres interpenetrants, a utiliser en tant produits de scellement medicaux a haute resistance
US6358258B1 (en) * 1999-09-14 2002-03-19 Abbott Laboratories Device and method for performing end-to-side anastomosis
DE60008001T2 (de) 1999-09-21 2004-09-02 Institut De Cardiologie De Montreal, Montreal Lokale verabreichung von 17-beta estradiol zur verbesserung der vaskularen endothelialen funktion nach gefässverletzungen
US6368285B1 (en) * 1999-09-21 2002-04-09 Biosense, Inc. Method and apparatus for mapping a chamber of a heart
US6385476B1 (en) 1999-09-21 2002-05-07 Biosense, Inc. Method and apparatus for intracardially surveying a condition of a chamber of a heart
US20040229856A1 (en) 1999-09-21 2004-11-18 Baskaran Chandrasekar Local delivery of 17-beta estradiol for preventing vascular intimal hyperplasia and for improving vascular endothelium function after vascular injury
WO2001024775A1 (fr) 1999-10-01 2001-04-12 Essentia Biosystems, Inc. Compositions de gelifiant
MXPA02001450A (es) 1999-10-05 2002-08-30 Transkaryotic Therapies Inc Matrices hibridas y mezclas de matriz hibridas.
US6748258B1 (en) 1999-11-05 2004-06-08 Scimed Life Systems, Inc. Method and devices for heart treatment
US6916488B1 (en) 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
US6992172B1 (en) * 1999-11-12 2006-01-31 Fibrogen, Inc. Recombinant gelatins
US6360129B1 (en) * 1999-12-13 2002-03-19 Cardiac Pacemakers, Inc. Mannitol/hydrogel cap for tissue-insertable connections
US6241710B1 (en) 1999-12-20 2001-06-05 Tricardia Llc Hypodermic needle with weeping tip and method of use
US6706034B1 (en) * 1999-12-30 2004-03-16 Advanced Cardiovascular Systems, Inc. Process for agent retention in biological tissues
US6547806B1 (en) 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
EP1258484B1 (fr) 2000-02-18 2009-01-14 Kyowa Hakko Kirin Co., Ltd. Nouveaux composes d'isoxazole et de thiazole et leur utilisation en tant que medicaments
US6346098B1 (en) * 2000-03-07 2002-02-12 The Board Of Trustees Of The Leland Stanford Junior University Methods and kits for locally administering an active agent to an interstitial space of a host
AUPQ618400A0 (en) 2000-03-13 2000-04-06 Baramy Engineering Pty Ltd A gross pollutant trap
US6458098B1 (en) 2000-03-17 2002-10-01 Nozomu Kanesaka Vascular therapy device
US6683192B2 (en) 2000-03-30 2004-01-27 Curis, Inc. Small organic molecule regulators of cell proliferation
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US6589549B2 (en) 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
WO2002000173A2 (fr) 2000-06-26 2002-01-03 Rxkinetix, Inc. Procedes d'utilisation de composition d'administration pour developper, activer, determiner ou mobiliser une ou plusieurs cellules souches multipotentes, a autorenouvellement et determinees
TWI257307B (en) 2000-07-12 2006-07-01 Orthologic Corp Pharmaceutical composition for cardiac tissue repair
US6548081B2 (en) * 2000-07-28 2003-04-15 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers
US6478775B1 (en) 2000-10-02 2002-11-12 Genyx Medical Inc. Device for delivering non-biodegradable bulking composition to a urological site
US6808483B1 (en) 2000-10-03 2004-10-26 Paul A. Spence Implantable heart assist devices and methods
US6554801B1 (en) * 2000-10-26 2003-04-29 Advanced Cardiovascular Systems, Inc. Directional needle injection drug delivery device and method of use
DE60125973D1 (de) 2000-11-15 2007-02-22 Biosyntech Canada Inc Verfahren zur wiederherstellung einer geschädigten bandscheibe
US20020072706A1 (en) 2000-12-11 2002-06-13 Thomas Hiblar Transluminal drug delivery catheter
US6846319B2 (en) 2000-12-14 2005-01-25 Core Medical, Inc. Devices for sealing openings through tissue and apparatus and methods for delivering them
US6692466B1 (en) * 2000-12-21 2004-02-17 Advanced Cardiovascular Systems, Inc. Drug delivery catheter with retractable needle
US6599267B1 (en) 2000-12-22 2003-07-29 Advanced Cardiovascular Systems, Inc. Transluminal injection device for intravascular drug delivery
EP2314293B1 (fr) * 2001-01-16 2017-01-04 Vascular Therapies, LLC Dispositif implantable contenant un matériel de matrice résorbable et rapamycin pour la prévention ou traitement des maladies vasculo-proliferatives
US6602241B2 (en) 2001-01-17 2003-08-05 Transvascular, Inc. Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
US6612977B2 (en) * 2001-01-23 2003-09-02 American Medical Systems Inc. Sling delivery system and method of use
WO2002068383A2 (fr) 2001-02-22 2002-09-06 Anika Therapeutics, Inc. Hyaluronane à modification thiol
WO2002067796A1 (fr) 2001-02-28 2002-09-06 Rex Medical, L.P. Appareil d'administration de fluide d'ablation destine au traitement des neoplasmes
US6565530B2 (en) * 2001-02-28 2003-05-20 Scimed Life Systems, Inc. Immobilizing objects in the body
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US20020124855A1 (en) 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
WO2002072166A1 (fr) 2001-03-13 2002-09-19 Biocure, Inc. Compositions destinees a l'administration de medicaments
CA2440387A1 (fr) 2001-03-23 2002-10-03 Durect Corporation Administration de medicaments au moyen de dispositifs a liberation lente implantes dans un tissu myocardique ou dans la cavite pericardique
US7029838B2 (en) 2001-03-30 2006-04-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized contructs for implantation to provide blood perfusion
US7396582B2 (en) * 2001-04-06 2008-07-08 Advanced Cardiovascular Systems, Inc. Medical device chemically modified by plasma polymerization
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US6628988B2 (en) 2001-04-27 2003-09-30 Cardiac Pacemakers, Inc. Apparatus and method for reversal of myocardial remodeling with electrical stimulation
US6887857B2 (en) 2001-04-27 2005-05-03 Scimed Life Systems, Inc. Microparticle protection of therapeutic agents
US7311731B2 (en) * 2001-04-27 2007-12-25 Richard C. Satterfield Prevention of myocardial infarction induced ventricular expansion and remodeling
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
US6702744B2 (en) * 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US6723067B2 (en) * 2001-07-26 2004-04-20 David H. Nielson Apparatus for delivering aerosolized fibrin endoscopically to a wound
CA2456806C (fr) 2001-08-08 2011-10-18 Brown University Research Foundation Procedes de micronisation de medicaments hydrophobes
US6663596B2 (en) 2001-08-13 2003-12-16 Scimed Life Systems, Inc. Delivering material to a patient
JP2003062089A (ja) 2001-08-24 2003-03-04 Sumitomo Bakelite Co Ltd 医療用コネクター
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
US7037289B2 (en) * 2001-09-12 2006-05-02 3M Innovative Properties Company Apparatus and methods for dispensing an adhesive tissue sealant
US6790455B2 (en) 2001-09-14 2004-09-14 The Research Foundation At State University Of New York Cell delivery system comprising a fibrous matrix and cells
US7112587B2 (en) 2001-09-21 2006-09-26 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
CA2460787A1 (fr) 2001-09-28 2003-04-03 Esperion Therapeutics, Inc. Prevention et traitement de la restenose par l'administration locale d'un medicament
US6893431B2 (en) 2001-10-15 2005-05-17 Scimed Life Systems, Inc. Medical device for delivering patches
EP1446453A1 (fr) * 2001-11-07 2004-08-18 Universität Zürich Matrice synthetique de croissance cellulaire interne et de regeneration tissulaire controlees
US7035092B2 (en) * 2001-11-08 2006-04-25 Apple Computer, Inc. Computer controlled display device
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US6973349B2 (en) 2001-12-05 2005-12-06 Cardiac Pacemakers, Inc. Method and apparatus for minimizing post-infarct ventricular remodeling
AU2003217271A1 (en) * 2002-01-29 2003-09-02 A. Mark Colb Endothelialization of vascular surfaces
US7169127B2 (en) * 2002-02-21 2007-01-30 Boston Scientific Scimed, Inc. Pressure apron direct injection catheter
JP4229621B2 (ja) 2002-03-05 2009-02-25 修 加藤 薬液注入カテーテル
WO2003079985A2 (fr) 2002-03-18 2003-10-02 Carnegie Mellon University Procede et appareil permettant de preparer un squelette biomimetique
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
CA2525994C (fr) 2002-06-24 2012-10-16 Tufts University Biomateriaux a base de soie et leurs methodes d'utilisation
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US7063679B2 (en) * 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US7008411B1 (en) * 2002-09-30 2006-03-07 Advanced Cardiovascular Systems, Inc. Method and apparatus for treating vulnerable plaque
US7438692B2 (en) 2002-10-18 2008-10-21 Mark Tsonton Localization mechanism for an MRI compatible biopsy device
WO2004058305A2 (fr) 2002-12-24 2004-07-15 An-Go-Gen Inc. Therapie d'encapsulation de cellule
CA2511521C (fr) 2002-12-30 2012-02-07 Angiotech International Ag Liberation de medicaments a partir d'une composition polymere a gelification rapide
US7393339B2 (en) 2003-02-21 2008-07-01 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20050015048A1 (en) * 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
WO2004082491A1 (fr) 2003-03-18 2004-09-30 Robert Ganz Procede et dispositif d'administration d'une substance a des couches de tissus
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
MXPA05011896A (es) 2003-05-05 2006-05-25 Univ Ben Gurion Preparaciones polimericas reticuladas inyectables y sus usos.
WO2005010172A2 (fr) * 2003-07-16 2005-02-03 Boston Scientific Limited Structures d'echafaudage alignees pour regeneration myocardique accrue
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
CA2535346A1 (fr) * 2003-08-13 2005-03-03 Medtronic, Inc. Systemes de distribution d'agents actifs comprenant une seule couche d'un melange de polymeres miscibles, dispositifs medicaux et procedes
US7998112B2 (en) * 2003-09-30 2011-08-16 Abbott Cardiovascular Systems Inc. Deflectable catheter assembly and method of making same
KR20060130580A (ko) 2003-12-10 2006-12-19 셀룰라 바이오엔지니어링 인코포레이티드 연조직 형태 복원을 위한 조성물 및 방법
US7273469B1 (en) 2003-12-31 2007-09-25 Advanced Cardiovascular Systems, Inc. Modified needle catheter for directional orientation delivery
US7976847B2 (en) 2004-01-13 2011-07-12 Vasogenix Pharmaceuticals, Inc. Controlled release CGRP delivery composition for cardiovascular and renal indications
US20050186240A1 (en) 2004-02-23 2005-08-25 Ringeisen Timothy A. Gel suitable for implantation and delivery system
US8067031B2 (en) 2004-04-28 2011-11-29 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US20060293612A1 (en) 2004-06-24 2006-12-28 Boston Scientific Scimed, Inc. Apparatus and method for treating occluded vasculature
JP2006014570A (ja) 2004-06-29 2006-01-12 Muscle Corp 電力回生方法およびそれを用いたコンバータ装置
EP4023240A1 (fr) 2004-07-06 2022-07-06 3D Matrix, Inc. Compositions peptidiques amphiphiles purifiées et utilisations de celles-ci
GB0419653D0 (en) 2004-09-04 2004-10-06 Psimedica Ltd Needle assembly
US20060122150A1 (en) 2004-09-30 2006-06-08 Argentieri Dennis C Pharmaceutical composition and method for treating a joint-capsule arthropathy
US20060149392A1 (en) 2004-12-07 2006-07-06 Kuo-Huang Hsieh Biomaterials for guided tissue regeneration and drug delivery
US7854944B2 (en) 2004-12-17 2010-12-21 Advanced Cardiovascular Systems, Inc. Tissue regeneration
US8303972B2 (en) * 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
JP4762785B2 (ja) 2005-06-02 2011-08-31 西川ゴム工業株式会社 ゼラチンスポンジ
EP2623116A1 (fr) * 2005-07-27 2013-08-07 Eli Lilly and Company Méthode de traitement de cellules cancéreuses pour créer une cellule canéreuse modifiée provoquant une réponse immunogène
EP1942957B1 (fr) 2005-10-27 2012-07-11 Coloplast A/S Squelette biodegradable avec materiau de matrice extracellulaire
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US8741326B2 (en) 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9005672B2 (en) * 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
US8221744B2 (en) 2007-09-19 2012-07-17 Abbott Cardiovascular Systems Inc. Cytocompatible alginate gels
US7942854B1 (en) 2008-01-29 2011-05-17 Abbott Cardiovascular Systems Inc. Agent delivery catheter including an anchor and injection needle
US8377033B2 (en) 2010-09-08 2013-02-19 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050013A2 (fr) * 2002-11-29 2004-06-17 The Regents Of The University Of California Compositions de materiaux et systemes et procedes associes pour le traitement de conditions cardiaques
WO2004091592A2 (fr) * 2003-04-15 2004-10-28 Guidant Corporation, V.I. Procedes et compositions destines au traitement d'infarctus du myocarde
WO2006113407A2 (fr) * 2005-04-19 2006-10-26 Advanced Cardiovascular Systems, Inc. Supports biologiques a base d'hydrogels et revetements de dispositifs biomedicaux
WO2007145909A2 (fr) * 2006-06-05 2007-12-21 Abbott Cardiovascular Systems Inc. Compositions et méthodes pour traiter une lésion post-infarctus du myocarde

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHENG SHU X ET AL: "In situ crosslinkable hyaluronan hydrogels for tissue engineering", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 25, no. 7-8, 1 March 2004 (2004-03-01), pages 1339 - 1348, XP004475078, ISSN: 0142-9612 *

Also Published As

Publication number Publication date
US20150017265A9 (en) 2015-01-15
JP2010516349A (ja) 2010-05-20
EP2452699A1 (fr) 2012-05-16
US20090022817A1 (en) 2009-01-22
EP2109469B1 (fr) 2014-06-04
US20170258961A9 (en) 2017-09-14
WO2008089452A2 (fr) 2008-07-24
US9005672B2 (en) 2015-04-14
EP2452699B1 (fr) 2016-04-20
EP2109469A2 (fr) 2009-10-21
US9775930B2 (en) 2017-10-03
US20150209473A1 (en) 2015-07-30
JP5542449B2 (ja) 2014-07-09

Similar Documents

Publication Publication Date Title
WO2008089452A3 (fr) Procédés de modification de développement de l'infarctus du myocarde
WO2008063418A3 (fr) Systèmes de gélification bi-composant modifiés, méthodes d'utilisation et procédés de fabrication
HK1256737A1 (zh) 通过改变细胞表面信号和信号比选择性扩增不同的t细胞亚群
EP4038178A4 (fr) Compositions nutritives et procédés, kits et compositions cellulaires pour la production de celles-ci
WO2005055983A3 (fr) Procede de preparation de cocristaux a phase mixte avec des agents actifs
UA100228C2 (uk) Фармацевтична композиція, яка містить тетрагідрофолієву кислоту
WO2008130372A8 (fr) Production de stérols dans des levures et des champignons oléagineux
WO2010025064A3 (fr) Persistance d'un groupe dans une application de messagerie instantanée
WO2008060705A3 (fr) Anticorps anti-dll4 et leurs procédés d'utilisation
WO2009076676A3 (fr) Compositions et méthodes de production d'isoprène
WO2008064351A3 (fr) (r)-n-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8
WO2011084553A3 (fr) Compositions et utilisations de cis-1,1,1,4,4,4-hexafluorobut-2-ène
WO2008016490A3 (fr) Systèmes modifiés de gélification à deux composants, et leurs procédés d'utilisation et de fabrication
WO2010006173A3 (fr) Complexe minéral-acide aminé-polysaccharide
WO2004091645A3 (fr) Composition d'acide de romarin
WO2005097160A3 (fr) Modulation de nkg2d
WO2012024259A3 (fr) Agents gonflants, compositions moussables et mousses
WO2008060778A3 (fr) Compositions comportant un indicateur de performances
WO2008103847A3 (fr) Compositions à base de composés polycycliques pontés pour l'inhibition et le traitement de maladies
WO2007009050A3 (fr) Compositions hemostatiques, ensembles, systemes et methodes faisant appel a des agents hemostatiques particulaires formes a partir d'une mousse polymere hydrophile telle que le chitosane
WO2007139758A3 (fr) Délivrance de compositions de plusieurs composants
EP2402373A3 (fr) Anticorps anti-EphB4 et procédés d'utilisation associés
WO2008088779A3 (fr) Formes solides de 5-azacytidine et procédés de préparation de ces dernières
WO2005094353A3 (fr) Techniques de production de lymphocytes t regulateurs et utilisation de ceux-ci
HK1205999A1 (en) Process for the preparation of cement, mortars, concrete compositions containing calcium carbonate - based filler(s) (pre) - treated with ultrafine (uf) filler(s), compositions and cement products obtained and their applications

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2009546553

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008727952

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08727952

Country of ref document: EP

Kind code of ref document: A2