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WO2008087828A1 - マイクロチップ - Google Patents

マイクロチップ Download PDF

Info

Publication number
WO2008087828A1
WO2008087828A1 PCT/JP2007/074509 JP2007074509W WO2008087828A1 WO 2008087828 A1 WO2008087828 A1 WO 2008087828A1 JP 2007074509 W JP2007074509 W JP 2007074509W WO 2008087828 A1 WO2008087828 A1 WO 2008087828A1
Authority
WO
WIPO (PCT)
Prior art keywords
sub
valve portion
microchip
reagent
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/074509
Other languages
English (en)
French (fr)
Inventor
Akihisa Nakajima
Youichi Aoki
Kusunoki Higashino
Yasuhiro Sando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Konica Minolta Medical and Graphic Inc
Original Assignee
Konica Minolta Medical and Graphic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical and Graphic Inc filed Critical Konica Minolta Medical and Graphic Inc
Priority to JP2008553991A priority Critical patent/JPWO2008087828A1/ja
Publication of WO2008087828A1 publication Critical patent/WO2008087828A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

Abstract

　本発明の目的は、主流路に複数の副流路から試薬を順次送液して、目的物質を正確に検出できるマイクロチップを提供することである。本発明に係るマイクロチップは、試薬と試料の混合液が流れる主流路と、試薬が流れる副流路と、副流路の下流側端部に設けられた撥水バルブ部と、撥水バルブ部の下流側端部に設けられるとともに主流路の途中に接続される、撥水バルブ部よりも幅及び深さの大きい接続部と、を有することを特徴とする。
PCT/JP2007/074509 2007-01-18 2007-12-20 マイクロチップ Ceased WO2008087828A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008553991A JPWO2008087828A1 (ja) 2007-01-18 2007-12-20 マイクロチップ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007008973 2007-01-18
JP2007-008973 2007-01-18

Publications (1)

Publication Number Publication Date
WO2008087828A1 true WO2008087828A1 (ja) 2008-07-24

Family

ID=39635833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/074509 Ceased WO2008087828A1 (ja) 2007-01-18 2007-12-20 マイクロチップ

Country Status (2)

Country Link
JP (1) JPWO2008087828A1 (ja)
WO (1) WO2008087828A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012229985A (ja) * 2011-04-26 2012-11-22 Rohm Co Ltd マイクロチップ
JP2016052253A (ja) * 2014-09-02 2016-04-14 株式会社東芝 核酸検出カセット
JP2016527511A (ja) * 2013-07-29 2016-09-08 アトラス・ジェネティクス・リミテッドＡｔｌａｓ Ｇｅｎｅｔｉｃｓ Ｌｉｍｉｔｅｄ 流体カートリッジおよび液体サンプルの処理方法
US10821435B2 (en) 2014-09-02 2020-11-03 Canon Medical Systems Corporation Nucleic acid detection cassette
WO2025135053A1 (ja) * 2023-12-19 2025-06-26 住友ベークライト株式会社 計時装置、計時方法、流体制御装置、希釈装置および検査装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005017057A (ja) * 2003-06-25 2005-01-20 Aida Eng Ltd 液体注入構造及び該構造
JP2006247533A (ja) * 2005-03-10 2006-09-21 Bussan Nanotech Research Institute Inc マイクロチャネルチップ
WO2006112498A1 (ja) * 2005-04-20 2006-10-26 Konica Minolta Medical & Graphic, Inc. 検体を分析するための検査チップおよびマイクロ分析システム

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005017057A (ja) * 2003-06-25 2005-01-20 Aida Eng Ltd 液体注入構造及び該構造
JP2006247533A (ja) * 2005-03-10 2006-09-21 Bussan Nanotech Research Institute Inc マイクロチャネルチップ
WO2006112498A1 (ja) * 2005-04-20 2006-10-26 Konica Minolta Medical & Graphic, Inc. 検体を分析するための検査チップおよびマイクロ分析システム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012229985A (ja) * 2011-04-26 2012-11-22 Rohm Co Ltd マイクロチップ
JP2016527511A (ja) * 2013-07-29 2016-09-08 アトラス・ジェネティクス・リミテッドＡｔｌａｓ Ｇｅｎｅｔｉｃｓ Ｌｉｍｉｔｅｄ 流体カートリッジおよび液体サンプルの処理方法
JP2016052253A (ja) * 2014-09-02 2016-04-14 株式会社東芝 核酸検出カセット
US10821435B2 (en) 2014-09-02 2020-11-03 Canon Medical Systems Corporation Nucleic acid detection cassette
WO2025135053A1 (ja) * 2023-12-19 2025-06-26 住友ベークライト株式会社 計時装置、計時方法、流体制御装置、希釈装置および検査装置

Also Published As

Publication number Publication date
JPWO2008087828A1 (ja) 2010-05-06

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