[go: up one dir, main page]

WO2008068619A3 - Procédé perfectionné pour synthétiser la lamotrigine - Google Patents

Procédé perfectionné pour synthétiser la lamotrigine Download PDF

Info

Publication number
WO2008068619A3
WO2008068619A3 PCT/IB2007/004212 IB2007004212W WO2008068619A3 WO 2008068619 A3 WO2008068619 A3 WO 2008068619A3 IB 2007004212 W IB2007004212 W IB 2007004212W WO 2008068619 A3 WO2008068619 A3 WO 2008068619A3
Authority
WO
WIPO (PCT)
Prior art keywords
lamotrigine
synthesizing
improved method
preparing
formule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/004212
Other languages
English (en)
Other versions
WO2008068619A2 (fr
Inventor
Aguilar Carmen Arnalot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/376,094 priority Critical patent/US20120142919A1/en
Application filed by Medichem SA filed Critical Medichem SA
Priority to CA002659895A priority patent/CA2659895A1/fr
Priority to EP07870418A priority patent/EP2057130A2/fr
Publication of WO2008068619A2 publication Critical patent/WO2008068619A2/fr
Publication of WO2008068619A3 publication Critical patent/WO2008068619A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte d'une manière générale sur un procédé perfectionné pour préparer la lamotrigine et des composés apparentés. L'invention concerne des procédés pour préparer et purifier la lamotrigine, comprenant un hydrate de lamotrigine, le monohydrate de lamotrigine et la lamotrigine anhydre.
PCT/IB2007/004212 2006-08-02 2007-08-02 Procédé perfectionné pour synthétiser la lamotrigine Ceased WO2008068619A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/376,094 US20120142919A1 (en) 2006-08-02 2005-08-02 Method for synthesizing lamotrigine
CA002659895A CA2659895A1 (fr) 2006-08-02 2007-08-02 Procede perfectionne pour synthetiser la lamotrigine
EP07870418A EP2057130A2 (fr) 2006-08-02 2007-08-02 Procédé perfectionné pour synthétiser la lamotrigine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83482106P 2006-08-02 2006-08-02
US60/834,821 2006-08-02

Publications (2)

Publication Number Publication Date
WO2008068619A2 WO2008068619A2 (fr) 2008-06-12
WO2008068619A3 true WO2008068619A3 (fr) 2008-11-27

Family

ID=39492686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004212 Ceased WO2008068619A2 (fr) 2006-08-02 2007-08-02 Procédé perfectionné pour synthétiser la lamotrigine

Country Status (5)

Country Link
US (1) US20120142919A1 (fr)
EP (2) EP2128145A3 (fr)
AR (1) AR062198A1 (fr)
CA (1) CA2659895A1 (fr)
WO (1) WO2008068619A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103570637A (zh) * 2013-09-13 2014-02-12 盐城凯利药业有限公司 一种拉莫三嗪的制备方法
CN106491539B (zh) * 2016-12-19 2019-03-26 上海奥科达生物医药科技有限公司 一种拉莫三嗪干混悬剂及其制备方法
CN114948868B (zh) 2021-04-16 2023-04-14 上海奥科达医药科技股份有限公司 一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020934A1 (fr) * 1994-12-30 1996-07-11 The Wellcome Foundation Limited Procede de preparation de lamotrigine
WO1997000681A1 (fr) * 1995-06-23 1997-01-09 The Wellcome Foundation Limited Composition pharmaceutique contenant de la lamotrigine
EP0963980A2 (fr) * 1998-06-10 1999-12-15 The Wellcome Foundation Limited Dérivé de 1,2,4-triazine, la preparation et l'utilisation comme marqueur de référence pour verifié la pureté et la stabilité de "lamotrigine"
EP1127873A2 (fr) * 2000-02-25 2001-08-29 Chemagis Ltd. Procédé pour la préparation de benzoylcyanide amidinohydrazones
WO2004039767A1 (fr) * 2002-10-31 2004-05-13 Vita Cientifica, S.L. Procede de preparation d'un compose actif d'un point de vue pharmaceutique et sur un procede de preparation de son intermediaire
WO2005003104A2 (fr) * 2003-07-03 2005-01-13 Jubilant Organosys Limited Monohydrate de lamotrigine
WO2007138075A1 (fr) * 2006-05-31 2007-12-06 Calaire Chimie Sas Procédé de préparation de la lamotrigine et son chlorure de 2,3-dichlorobenzoyle intermédiaire

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3062603D1 (en) 1979-06-01 1983-05-11 Wellcome Found 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
AU530999B2 (en) 1979-06-01 1983-08-04 Wellcome Foundation Limited, The Substituted amino triazines and their use in treatment of cns disorders
GB9426448D0 (en) 1994-12-30 1995-03-01 Wellcome Found Process
AU1292400A (en) 1998-12-14 2000-07-03 Sharad Kumar Vyas An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
US6639072B1 (en) 2000-01-03 2003-10-28 Rpg Life Sciences Limited Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
WO2002068398A1 (fr) * 2001-02-27 2002-09-06 Teva Pharmaceutical Industries Ltd. Nouvelles formes cristallines de lamotrigine et leurs procedes de preparation
CA2366521C (fr) * 2001-12-24 2007-03-06 Brantford Chemicals Inc. Un procede nouveau et efficace de preparation de lamotrigine et d'autres 3,5-diamino-1,2,4-triazines substituees en position 6
WO2009061513A1 (fr) * 2007-11-09 2009-05-14 Thar Pharmaceuticals Formes cristallines de lamotrigine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996020934A1 (fr) * 1994-12-30 1996-07-11 The Wellcome Foundation Limited Procede de preparation de lamotrigine
WO1997000681A1 (fr) * 1995-06-23 1997-01-09 The Wellcome Foundation Limited Composition pharmaceutique contenant de la lamotrigine
EP0963980A2 (fr) * 1998-06-10 1999-12-15 The Wellcome Foundation Limited Dérivé de 1,2,4-triazine, la preparation et l'utilisation comme marqueur de référence pour verifié la pureté et la stabilité de "lamotrigine"
EP1127873A2 (fr) * 2000-02-25 2001-08-29 Chemagis Ltd. Procédé pour la préparation de benzoylcyanide amidinohydrazones
WO2004039767A1 (fr) * 2002-10-31 2004-05-13 Vita Cientifica, S.L. Procede de preparation d'un compose actif d'un point de vue pharmaceutique et sur un procede de preparation de son intermediaire
WO2005003104A2 (fr) * 2003-07-03 2005-01-13 Jubilant Organosys Limited Monohydrate de lamotrigine
WO2007138075A1 (fr) * 2006-05-31 2007-12-06 Calaire Chimie Sas Procédé de préparation de la lamotrigine et son chlorure de 2,3-dichlorobenzoyle intermédiaire

Also Published As

Publication number Publication date
EP2128145A3 (fr) 2010-03-31
CA2659895A1 (fr) 2008-06-12
US20120142919A1 (en) 2012-06-07
EP2057130A2 (fr) 2009-05-13
WO2008068619A2 (fr) 2008-06-12
AR062198A1 (es) 2008-10-22
EP2128145A2 (fr) 2009-12-02

Similar Documents

Publication Publication Date Title
WO2007035629A3 (fr) Inhibiteurs de dipeptidylpeptidase
WO2006127898A3 (fr) (s)-n-methylnaltrexone
WO2007103105A3 (fr) Procédés de préparation de produits à base de morphinan-6-one avec de faibles niveaux de composés de cétones alpha, bêta-insaturées
GB2445120B (en) Method for production, substitution or mining of gas hydrate
IL187586A (en) A method of generating dihydroquinazolines
WO2008075376A8 (fr) Formes polymorphes du bortézomibe et leur procédé de préparation
WO2006110783A3 (fr) Procede de fabrication de (s)-pregabaline
IL188431A0 (en) Process for preparing 3-arylmethylthio-and 3-heteroarylmethylthio-4,5-dihydro-
EP1824808A4 (fr) Processus de purification d'acide hydroxycarboxylique, processus de production d'ester cyclique et processus de production d'acide polyhydroxycarboxylique
WO2008140641A3 (fr) Palipéridone pure et ses procédés de préparation
WO2008021346A3 (fr) Palipéridone pure et ses procédés d'obtention
WO2007141593A3 (fr) Synthèse et préparations améliorées du métoprolol et de ses sels
WO2008068619A3 (fr) Procédé perfectionné pour synthétiser la lamotrigine
WO2007143152A3 (fr) Préparation de (s)-prégabaline nitrile
EP1751123A4 (fr) Processus pour préparer de l'irbésartan
WO2010148177A3 (fr) Composés, compositions, procédés de synthèse et procédés de traitement
WO2007016029A3 (fr) Diazepinoquinolines, synthese de ces dernieres et intermediaires correspondants
WO2007075452A3 (fr) Compositions lyophilisees d'un compose de triazolopyrimidine
EP1950191A4 (fr) Procede de production de l'acide 3,3,3-trifluoropropionique
WO2007081889A3 (fr) Production du dolasetron
IL193068A0 (en) Process for the stereoselective preparation of alcohols from alpha, beta-insaturated compounds
WO2007127309A3 (fr) Procede de synthese d'acide 3-isobutylglutarique
EP1930310A4 (fr) Procédé de production du 3,3,3-trifluoropropionaldéhyde
WO2007073937A3 (fr) Procede permettant de preparer des formes cristallines de l'orlistat
TW200738611A (en) 9-Chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2659895

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 2007870418

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07870418

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 12376094

Country of ref document: US