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WO2008066878A3 - Procédés et produits utilisés pour diagnostiquer le cancer - Google Patents

Procédés et produits utilisés pour diagnostiquer le cancer Download PDF

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Publication number
WO2008066878A3
WO2008066878A3 PCT/US2007/024553 US2007024553W WO2008066878A3 WO 2008066878 A3 WO2008066878 A3 WO 2008066878A3 US 2007024553 W US2007024553 W US 2007024553W WO 2008066878 A3 WO2008066878 A3 WO 2008066878A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cancer
products
diagnosing cancer
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/024553
Other languages
English (en)
Other versions
WO2008066878A2 (fr
WO2008066878A9 (fr
Inventor
Marcus Bosenberg
Viswanathan Muthasamy
Sekhar Duraisamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Vermont
Original Assignee
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Vermont filed Critical University of Vermont
Priority to US12/312,807 priority Critical patent/US20100143899A1/en
Publication of WO2008066878A2 publication Critical patent/WO2008066878A2/fr
Publication of WO2008066878A3 publication Critical patent/WO2008066878A3/fr
Publication of WO2008066878A9 publication Critical patent/WO2008066878A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Cette invention concerne des procédés et des kits utilisés pour détecter et diagnostiquer le cancer ou des états précancéreux. La méthylation de gènes spécifiques s'avère un élément indicateur du cancer, et les procédés de l'invention concernent, en partie, la détection des taux de méthylation dans les cellules utilisée comme élément de détermination du cancer ou d'un état précancéreux de la cellule.
PCT/US2007/024553 2005-05-17 2007-11-29 Procédés et produits utilisés pour diagnostiquer le cancer Ceased WO2008066878A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/312,807 US20100143899A1 (en) 2005-05-17 2007-11-29 Methods and products for diagnosing cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86175506P 2006-11-29 2006-11-29
US60/861,755 2006-11-29

Publications (3)

Publication Number Publication Date
WO2008066878A2 WO2008066878A2 (fr) 2008-06-05
WO2008066878A3 true WO2008066878A3 (fr) 2008-12-11
WO2008066878A9 WO2008066878A9 (fr) 2009-05-28

Family

ID=39468508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/024553 Ceased WO2008066878A2 (fr) 2005-05-17 2007-11-29 Procédés et produits utilisés pour diagnostiquer le cancer

Country Status (1)

Country Link
WO (1) WO2008066878A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008134020A1 (fr) 2007-04-26 2008-11-06 University Of Vermont And State Agricultural College Procédés et compositions de ccl18 et ccl3 pour la détection et le traitement du cancer
WO2009093213A2 (fr) * 2008-01-24 2009-07-30 Universite De Lausanne Procédé de prédiction et de diagnostic d'une tumeur cérébrale
CN101962684B (zh) * 2010-11-04 2012-03-28 徐州师范大学 黄牛pcsk1基因的单核苷酸多态性及其检测方法
WO2012081017A1 (fr) 2010-12-15 2012-06-21 Yeda Research And Development Co. Ltd. Compositions et procédés pour le traitement du cancer et de maladies neurodégénératives
EP3037545A1 (fr) * 2014-12-23 2016-06-29 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin Test de méthylation d'ADN pour le cancer de la prostate
WO2020019268A1 (fr) * 2018-07-26 2020-01-30 北京艾克伦医疗科技有限公司 Méthode pour identifier l'état d'un cancer du sein et kit
CN114410792B (zh) * 2022-02-10 2023-07-25 博尔诚（北京）科技有限公司 用于肾癌筛查的标志物、探针组合物及其应用
CN118441051B (zh) * 2024-05-28 2025-05-02 南通大学 一种与肺腺癌相关的meQTL-SNPs生物标志物及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095644A2 (fr) * 2004-04-04 2005-10-13 Oligene Gmbh Procede d'identification de signatures dans des profils d'expression genetique complexes
WO2007149269A2 (fr) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Marqueurs de méthylation destinés à une détection et un pronostic précoces de cancers du côlon

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095644A2 (fr) * 2004-04-04 2005-10-13 Oligene Gmbh Procede d'identification de signatures dans des profils d'expression genetique complexes
WO2007149269A2 (fr) * 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Marqueurs de méthylation destinés à une détection et un pronostic précoces de cancers du côlon

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FURUTA JUNICHI ET AL: "Silencing of the thrombomodulin gene in human malignant melanoma", MELANOMA RESEARCH, vol. 15, no. 1, February 2005 (2005-02-01), pages 15 - 20, XP009103389, ISSN: 0960-8931 *
GILLIS JOHN STUART: "Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 4, no. 1, 4 July 2006 (2006-07-04), pages 27, XP021018978, ISSN: 1479-5876 *
KORABIOWSKA MONIKA ET AL: "Analysis of adenomatous polyposis coli gene expression, APC locus-microsatellite instability and APC promoter methylation in the progression of melanocytic tumours", MODERN PATHOLOGY, vol. 17, no. 12, December 2004 (2004-12-01), pages 1539 - 1544, XP002489097, ISSN: 0893-3952 *
MIRMOHAMMADSADEGH ALIREZA ET AL: "Epigenetic silencing of the PTEN gene in melanoma.", CANCER RESEARCH 1 JUL 2006, vol. 66, no. 13, 1 July 2006 (2006-07-01), pages 6546 - 6552, XP002489096, ISSN: 0008-5472 *
MUTHUSAMY VISWANATHAN ET AL: "Epigenetic silencing of novel tumor suppressors in malignant melanoma", CANCER RESEARCH, vol. 66, no. 23, December 2006 (2006-12-01), pages 11187 - 11193, XP002489098, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2008066878A2 (fr) 2008-06-05
WO2008066878A9 (fr) 2009-05-28

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