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WO2008065500A3 - Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i - Google Patents

Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i Download PDF

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Publication number
WO2008065500A3
WO2008065500A3 PCT/IB2007/003604 IB2007003604W WO2008065500A3 WO 2008065500 A3 WO2008065500 A3 WO 2008065500A3 IB 2007003604 W IB2007003604 W IB 2007003604W WO 2008065500 A3 WO2008065500 A3 WO 2008065500A3
Authority
WO
WIPO (PCT)
Prior art keywords
czero
membered
alkylene
heteroaryl
heterocydoalkyi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/003604
Other languages
English (en)
Other versions
WO2008065500A2 (fr
Inventor
Iii John Adams Lowe
Subas Man Sakya
Mark Allen Sanner
Jotham Wadsworth Coe
Stanton Furst Mchardy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of WO2008065500A2 publication Critical patent/WO2008065500A2/fr
Publication of WO2008065500A3 publication Critical patent/WO2008065500A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une série d'hétéroayl amides substitués de formule I, dans laquelle les groupes HET, A, X1 à X4, et R1 à R12 sont définis tels que dans la spécification, qui révèlent une activité en tant qu'inhibiteurs du transport de la glycine. La présente invention concerne également leurs sels pharmaceutiquement acceptables, les compositions pharmaceutiques les contenant, et leur utilisation dans l'amélioration de la cognition et le traitement des symptômes positifs et négatifs de la schizophrénie et d'autres psychoses chez les mammifères, y compris les humains.
PCT/IB2007/003604 2006-11-30 2007-11-19 Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i Ceased WO2008065500A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86789506P 2006-11-30 2006-11-30
US60/867,895 2006-11-30

Publications (2)

Publication Number Publication Date
WO2008065500A2 WO2008065500A2 (fr) 2008-06-05
WO2008065500A3 true WO2008065500A3 (fr) 2008-11-13

Family

ID=39251256

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003604 Ceased WO2008065500A2 (fr) 2006-11-30 2007-11-19 Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i

Country Status (1)

Country Link
WO (1) WO2008065500A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11426412B2 (en) 2017-10-18 2022-08-30 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors

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CL2008002241A1 (es) * 2007-07-31 2009-12-28 Bayer Cropscience Sa Compuestos derivados de (hetero)aril-metilen-n-cicloalquil carboxamida condensados de 6 elementos con n-sustituido; composicion funguicida que comprende uno de dichos compuestos; y metodo para el control hongos fitopatogenos de cultivos agricolas.
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
AU2009305005A1 (en) * 2008-10-14 2010-04-22 Actelion Pharmaceuticals Ltd Phenethylamide derivatives and their heterocyclic analogues
CN102317259B (zh) * 2009-02-17 2015-12-02 拜尔农科股份公司 杀真菌n-(苯基环烷基)羧酰胺，n-(苄基环烷基)羧酰胺和硫代羧酰胺衍生物
US8623898B2 (en) 2009-03-19 2014-01-07 Taisho Pharmaceutical Co., Ltd. Glycine transporter inhibiting substances
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
AR077472A1 (es) * 2009-07-15 2011-08-31 Taisho Pharmaceutical Co Ltd Inhibidores de transportador de glicina
US8846721B2 (en) * 2010-01-25 2014-09-30 Kareus Therapeutics Sa Compositions for reducing aβ 42 production and their use in treating alzheimer's disease (AD)
PL2595961T3 (pl) * 2010-07-20 2017-10-31 Bayer Ip Gmbh Benzocykloalkeny jako środki przeciwgrzybicze
JP2013249257A (ja) * 2010-09-16 2013-12-12 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害物質
JP2013249258A (ja) * 2010-09-17 2013-12-12 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害物質
TW201225957A (en) 2010-09-17 2012-07-01 Taisho Pharmaceutical Co Ltd Glycine transporter inhibitor
US20140249105A1 (en) 2011-07-25 2014-09-04 Diverchim Novel ceramide analogues, processes for preparing same and uses thereof
AU2012327076B2 (en) * 2011-10-18 2017-07-06 Astellas Pharma Inc. Bicyclic heterocyclic compound
TWI594695B (zh) * 2012-04-20 2017-08-11 拜耳作物科學公司 Ｎ－環烷基－ｎ－［（雜環基苯基）亞甲基］－（硫代）甲醯胺衍生物
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie
UY35420A (es) 2013-03-15 2014-10-31 Abbvie Inc Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
AR095264A1 (es) * 2013-03-15 2015-09-30 Abbvie Deutschland Compuestos de acilaminocicloalquilo apropiados para tratar trastornos que responden a la modulación del receptor de dopamina d3
KR20150135460A (ko) * 2013-03-28 2015-12-02 우베 고산 가부시키가이샤 치환 비아릴 화합물
CA2960271A1 (fr) * 2014-09-10 2016-03-17 Epizyme, Inc. Composes de cyclohexylamine substitues
AU2016323992B2 (en) * 2015-09-16 2021-05-06 Eli Lilly And Company Farnesoid X receptor agonists and uses thereof
CA3056019A1 (fr) 2017-03-15 2018-09-20 Metacrine, Inc. Agonistes du recepteur farnesoide x et leurs utilisations
EP3596053B1 (fr) 2017-03-15 2023-08-16 Organovo, Inc. Agonistes du récepteur farnésoïde x et leurs utilisations
CN111491920B (zh) * 2017-10-20 2024-01-30 范德比尔特大学 毒蕈碱性乙酰胆碱受体m4的拮抗剂
US11352344B2 (en) 2017-10-31 2022-06-07 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
JP7268026B2 (ja) 2017-12-05 2023-05-02 サノビオン ファーマシューティカルズ インク 非ラセミ混合物およびその使用
MX2020005517A (es) 2017-12-05 2020-11-09 Sunovion Pharmaceuticals Inc Formas cristalinas y metodos de produccion de las mismas.
CA3090130A1 (fr) 2018-02-02 2019-08-08 Vanderbilt University Antagonistes du recepteur muscarinique de l'acetylcholine m4
DK3852748T3 (da) 2018-09-18 2025-10-06 Lilly Co Eli Farnesoid x-receptor-agonister og deres anvendelse
US11160758B2 (en) 2019-06-04 2021-11-02 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066456A2 (fr) * 2001-02-16 2002-08-29 Allelix Neuroscience, Inc. Inhibiteurs de glyt-1
EP1284257A2 (fr) * 2001-08-16 2003-02-19 Pfizer Products Inc. Ethers aromatiques difluorométhylène et leur utilisation en tant qu'inhibiteurs de transporteur de glycine type 1
WO2005037216A2 (fr) * 2003-10-14 2005-04-28 Pfizer Products Inc. Derives [3.1.0] bicycliques utilises comme inhibiteurs des transporteurs de glycine
WO2006106425A1 (fr) * 2005-04-08 2006-10-12 Pfizer Products Inc. Heteroarylamides bicycliques [3.1.0 ] comme inhibiteurs de transport de la glycine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066456A2 (fr) * 2001-02-16 2002-08-29 Allelix Neuroscience, Inc. Inhibiteurs de glyt-1
EP1284257A2 (fr) * 2001-08-16 2003-02-19 Pfizer Products Inc. Ethers aromatiques difluorométhylène et leur utilisation en tant qu'inhibiteurs de transporteur de glycine type 1
WO2005037216A2 (fr) * 2003-10-14 2005-04-28 Pfizer Products Inc. Derives [3.1.0] bicycliques utilises comme inhibiteurs des transporteurs de glycine
WO2006106425A1 (fr) * 2005-04-08 2006-10-12 Pfizer Products Inc. Heteroarylamides bicycliques [3.1.0 ] comme inhibiteurs de transport de la glycine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERGERON R ET AL: "MODULATION OF N-METHYL-D-ASPARTATE RECEPTOR FUNCTION BY GLYCINE TRANSPORT", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 95, December 1998 (1998-12-01), pages 15730 - 15734, XP002305700, ISSN: 0027-8424 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11833156B2 (en) 2017-09-22 2023-12-05 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
US12357639B2 (en) 2017-09-22 2025-07-15 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
US11426412B2 (en) 2017-10-18 2022-08-30 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
US11529341B2 (en) 2018-03-13 2022-12-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation

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Publication number Publication date
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