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WO2008065544A3 - Genetic predictors of risk for type 2 diabetes mellitus - Google Patents

Genetic predictors of risk for type 2 diabetes mellitus Download PDF

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Publication number
WO2008065544A3
WO2008065544A3 PCT/IB2007/004361 IB2007004361W WO2008065544A3 WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3 IB 2007004361 W IB2007004361 W IB 2007004361W WO 2008065544 A3 WO2008065544 A3 WO 2008065544A3
Authority
WO
WIPO (PCT)
Prior art keywords
risk
type
diabetes mellitus
t2dm
genetic predictors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/004361
Other languages
French (fr)
Other versions
WO2008065544A2 (en
Inventor
Constantin Polychronakos
Rob Sladek
Philippe Froguel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Original Assignee
McGill University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University filed Critical McGill University
Publication of WO2008065544A2 publication Critical patent/WO2008065544A2/en
Anticipated expiration legal-status Critical
Publication of WO2008065544A3 publication Critical patent/WO2008065544A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods of analyzing individuals at risk for the development of Type 2 diabetes mellitus (T2DM). Nucleic acids obtained from biological samples of individuals suffering from T2DM have been analyzed and SNPs associated with T2DM genes have been discovered. In addition, SNPs in linkage disequilibrium with T2DM genes are described.
PCT/IB2007/004361 2006-09-11 2007-09-11 Genetic predictors of risk for type 2 diabetes mellitus Ceased WO2008065544A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84358606P 2006-09-11 2006-09-11
US60/843,586 2006-09-11

Publications (2)

Publication Number Publication Date
WO2008065544A2 WO2008065544A2 (en) 2008-06-05
WO2008065544A3 true WO2008065544A3 (en) 2009-03-19

Family

ID=39468332

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/004361 Ceased WO2008065544A2 (en) 2006-09-11 2007-09-11 Genetic predictors of risk for type 2 diabetes mellitus

Country Status (1)

Country Link
WO (1) WO2008065544A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130022983A1 (en) 2009-10-26 2013-01-24 Externautics S.P.A. Colon and Rectal Tumor Markers and Methods of Use Thereof
WO2011051280A1 (en) 2009-10-26 2011-05-05 Externautics S.P.A. Ovary tumor markers and methods of use thereof
US20120322075A1 (en) 2009-10-26 2012-12-20 Externautics S.P.A. Lung Tumor Markers and Methods of Use Thereof
CN104395479B (en) * 2012-01-27 2019-03-15 香港中文大学 Biomarkers for diabetes
BR112022017770A2 (en) * 2020-03-06 2022-11-29 Denovo Biopharma Llc ISOLATED POLYNUCLEOTIDE; PANEL OF ISOLATED POLYNUCLEOTIDES; KIT COMPRISING THE ISOLATED POLYNUCLEOTIDE OR PANEL; MICROARRANGEMENT; REAGENT; KIT COMPRISING THE REAGENT; KIT COMPRISING THE ISOLATED POLYNUCLEOTIDE OR PANEL; COMPLEMENTARY DIAGNOSTIC METHOD; METHOD FOR CLASSIFIING AN INDIVIDUAL FOR ELIGIBILITY FOR A TREATMENT; METHOD FOR SCREENING AN INDIVIDUAL OR A POPULATION OF INDIVIDUALS FOR TREATMENT; METHOD FOR MONITORING AN INDIVIDUAL DURING TREATMENT; METHOD FOR IDENTIFYING A DRUG TARGET; METHOD FOR TREATMENT OF DISEASE OR DISORDER OF THE CENTRAL NERVOUS SYSTEM (CNS) IN AN INDIVIDUAL; USE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004042358A2 (en) * 2002-11-01 2004-05-21 Decode Genetics Ehf. HUMAN TYPE II DIABETES GENE-SLIT-3 LOCATED ON CHROMOSOME 5q35
FR2847263A1 (en) * 2002-11-18 2004-05-21 Commissariat Energie Atomique SPECIFIC POLYNUCLEOTIDE OF THE PANCREATIC CELL BETA OF THE ISLANDS OF LANGERHANS
US20050147987A1 (en) * 2000-09-08 2005-07-07 Applera Corporation (Ny) Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof
WO2006022634A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
WO2008065682A2 (en) * 2006-11-30 2008-06-05 Decode Genetics Ehf. Genetic susceptibility variants of type 2 diabetes mellitus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050147987A1 (en) * 2000-09-08 2005-07-07 Applera Corporation (Ny) Polymorphisms in known genes associated with type II diabetes and obesity, methods of detection and uses thereof
WO2004042358A2 (en) * 2002-11-01 2004-05-21 Decode Genetics Ehf. HUMAN TYPE II DIABETES GENE-SLIT-3 LOCATED ON CHROMOSOME 5q35
FR2847263A1 (en) * 2002-11-18 2004-05-21 Commissariat Energie Atomique SPECIFIC POLYNUCLEOTIDE OF THE PANCREATIC CELL BETA OF THE ISLANDS OF LANGERHANS
WO2006022634A1 (en) * 2004-07-22 2006-03-02 Sequenom, Inc. Methods for identifying risk of type ii diabetes and treatments thereof
WO2008065682A2 (en) * 2006-11-30 2008-06-05 Decode Genetics Ehf. Genetic susceptibility variants of type 2 diabetes mellitus

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
DATABASE ENTREZ PROTEIN [online] NCBI; 18 May 2005 (2005-05-18), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497998, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 *
DATABASE ENTREZ PROTEIN [online] NCBI; 7 May 2008 (2008-05-07), "CAH72347. Reports calmodulin bindin...[gi:55665770]", XP002497997, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV/ENTREZ/VIEWER.FCGI?DB=PROTEIN Database accession no. 55665770 *
DATABASE PROBE [online] ncbi; 22 February 2006 (2006-02-22), "rs13266634", XP002509338, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. Pr003758580.1 *
DATABASE SNP [online] NCBI; 10 October 2003 (2003-10-10), "rs1193179", XP002497772, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs1193179 *
DATABASE SNP [online] NCBI; 13 September 2004 (2004-09-13), "rs3266634", XP002509337, retrieved from HTTP://WWW.NCBI.NLM.NIH.GOV Database accession no. rs13266634 *
DIABETES GENETICS INITIATIVE OF BROAD INSTITUTE OF HARVARD AND MIT, LUND UNIVERSITY, AND NOVARTIS INSTITUTES OF BIOMEDICAL RESEARC: "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.", SCIENCE (NEW YORK, N.Y.) 1 JUN 2007, vol. 316, no. 5829, 1 June 2007 (2007-06-01), pages 1331 - 1336, XP002509336, ISSN: 1095-9203 *
GRANT STRUAN F A ET AL: "Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, vol. 38, no. 3, 1 March 2006 (2006-03-01), pages 320 - 323, XP009096714, ISSN: 1061-4036 *
KANG EUN SEOK ET AL: "The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes.", May 2005, DIABETES CARE MAY 2005, VOL. 28, NR. 5, PAGE(S) 1139 - 1144, ISSN: 0149-5992, XP002496473 *
SLADEK ROBERT ET AL: "A genome-wide association study identifies novel risk loci for type 2 diabetes", NATURE, NATURE PUBLISHING GROUP, LONDON, UK, vol. 445, no. 7130, 22 February 2007 (2007-02-22), pages 881 - 885, XP002465137, ISSN: 0028-0836 *
STEPHANE CAUCHI ET AL: "Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study", 22 January 2008, JOURNAL OF MOLECULAR MEDICINE, SPRINGER, BERLIN, DE, PAGE(S) 341 - 348, ISSN: 1432-1440, XP019576423 *

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Publication number Publication date
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