WO2008065544A2 - Genetic predictors of risk for type 2 diabetes mellitus - Google Patents

Abstract

Methods of analyzing individuals at risk for the development of Type 2 diabetes mellitus (T2DM). Nucleic acids obtained from biological samples of individuals suffering from T2DM have been analyzed and SNPs associated with T2DM genes have been discovered. In addition, SNPs in linkage disequilibrium with T2DM genes are described.

Description

GENETIC PREDICTORS OF RISK FOR TYPE 2 DIABETES MELLITUS

RELATED APPLICATION

This application claims the benefit of the filing date of U.S. provisional application 60/843,586, filed September 11, 2006 and entitled Genetic Predictors of Risk for Type 2 Diabetes Mellitus. The entire teachings of the referenced provisional application are expressly incorporated herein by reference.

BACKGROUND

Type 2 diabetes mellitus (T2DM) is the most common metabolic disease and a major cause of morbidity and mortality. Its rapidly increasing prevalence is thought to be due to environmental factors (increased availability of food and decreased opportunity /motivation for physical activity), acting on a substrate of genetic susceptibility. The latter must be important, as the heritability T2DM is one of the highest among common multifactorial diseases (reviewed in Permutt et al., 2005). Except for rare monogenic forms, (Maturity onset of the Young (MODY), neonatal and mitochondrial diabetes) it is clear that in the majority of cases this genetic susceptibility is a complex genetic trait, dependent on multiple loci. Knowledge of these loci is expected to permit early, presymptomatic detection of the disease and, possibly, to identify subtypes among phenotypically identical cases that may respond differentially to specific treatments.

Identification of the genetic factors implicated inT2DM has been the subject of intense research. Although linkage studies have elucidated the cause of most monogenic forms of T2DM, they have failed to identify a major-effect locus in T2DM. The genetic risk factors for T2DM have been the subject of intense research. T2DM susceptibility is a complex genetic trait, dependent on multiple loci, most of which remain to be defined. Linkage studies have identified common variants in CAPNlO (Horikawa et al., 2000) (Tsuchiya et al., 2006), ENPPl (Meyre et al., 2005) (Grarup et al., 2006), HNF4A (Silander et al., 2004) (Love-Gregory et al., 2004) (Winckler et al., 2005) and ACDC (Hara et al., 2002) (Vasseur et al., 2002) that increase susceptibility to T2DM. However, the incremental risk attributable to each individual locus is small. Recently, linkage studies have identified a single fully replicated susceptibility locus that maps to the TCF7L2 gene and confers the largest and most consistent effect on T2DM risk reported to date (Grant et al., 2006). In parallel, candidate-gene studies have been pursued but most reported associations have suffered from poor reproducibility; replication studies or meta-analyses have unequivocally confirmed associations only with two loci, involving coding variants in the nuclear receptor PPARG (P 12A) (Deeb et al., 1998) (Altshuler et al., 2000) (Lohmueller et al., 2003) and the potassium channel KCNJIl (E23K) (Gloyn et al., 2003) (Laukkanen et al., 2004). Additional information about susceptibility loci and their contribution to T2DM is needed in order to more fully understand the risk of developing T2DM.

SUMMARY OF THE INVENTION

The present invention relates to a method of assessing or aiding in assessing whether an individual (e.g., a human) is at risk for developing Type 2 diabetes mellitus (T2DM), in which a (at least one, one or more) single nucleotide polymorphism (SNP) that is associated with T2DM (or a complement thereof/a complement of a SNP that is associated with T2DM) is used to analyze a sample (e.g., tissue, cells or cell components that contain genetic material) obtained from the individual for genetic material associated with T2DM. A SNP associated with T2DM (also referred to as a T2DM-associated SNP) is a SNP that has one allele with higher frequency in individuals with T2DM than in the general population. The risk allele of a SNP associated with T2DM is the allele that occurs more often (is more commonly present) in individuals with T2DM than in individuals who do not have T2DM. If the sample obtained from an individual being assessed for his/her risk of developing T2DM includes (contains) the risk allele of the T2DM associated SNP, then the individual is more likely to develop T2DM than an individual in whom the risk allele is not present. A SNP associated with T2DM (also referred to as a SNP associated with a gene associated with T2DM) can be located within (contained in) the gene associated with T2DM, such as in the transcribed region of the gene associated with T2DM; in the coding region of the gene associated with T2DM; in a non coding region of the gene associated with T2DM; in an intergenic region of the gene associated with T2DM; or in two regions (overlaps at least part of two regions) of the gene associated with T2DM. The SNP associated with T2DM can also be located outside (not contained in) the gene associated with T2DM, provided, for example, that it is located in such a manner that its detection is useful to identify an individual as having the gene associated with T2DM. The method of the present invention can be carried out to determine the occurrence (presence or absence) of a SNP (at least one SNP, one or more SNPs) associated with T2DM in a sample obtained from an individual, such as the occurrence of the risk allele of a SNP associated with T2DM. A particular individual's risk can be determined by assessing the risk allele or combination of risk alleles of T2DM-associated SNPs.

Samples which can be analyzed using the methods and compositions of the present invention can be any sample, obtained from an individual, that comprises genetic material that can be analyzed for one or more SNPs associated with T2DM or products (e.g., proteins, polypeptides, peptides) encoded by such genetic material.

Samples that can be used include, but are not limited to, blood or components thereof, bone marrow, tissues/organs and cells obtained from tissues/organs and body fluids (e.g., lymph, semen, saliva). Samples can be obtained from any individual in need of assessment, such as a human and other nonhuman mammals. The method of assessing or aiding in assessing an individual's risk of developing T2DM of this invention can be carried out by analyzing a sample for as few as one SNP associated with T2DM or by analyzing a sample for a group or collection of two or more SNPs associated with T2DM. Techniques known to those in the art for detecting nucleic acids in a sample can be used to analyze a sample for T2DM associated SNP(s). These techniques include, for example, hybridization techniques in which genetic material (e.g., DNA or RNA), as obtained from the sample or obtained and amplified (amplified DNA, RNA), is used. Alternatively, products (polypeptides, which includes proteins and peptides) encoded by DNA comprising a SNP associated with T2DM can be detected in a sample obtained from an individual to be assessed for his/her risk of developing T2DM. The presence of a polypeptide encoded by DNA comprising the risk allele of a SNP associated T2DM indicates that the individual is at risk of developing T2DM. Proteins encoded by DNA comprising a SNP associated with T2DM can be assessed for their function or activity and compared with the function or activity of a reference protein, which can be a protein encoded by corresponding wild type DNA or a protein encoded by DNA comprising a SNP associated with T2DM, which is not the risk allele. A difference in function or activity between a protein encoded by DNA comprising the risk allele of a SNP associated with T2DM and a reference protein can be assessed for its effects on contribution to T2DM. Also the subject of this invention are isolated nucleic acids comprising a SNP associated with T2DM or the complement of such a SNP, such as a SNP that is associated with a gene associated with T2DM. These genes include, but are not limited to, CAMTAl, TTC13, RYR2, CXCR4, DARS (also referred to herein as CXCR4/DARS), SLC6A20, VPS 13 A, FAM69B, HHEX (also referred to herein as HHEX/IDE), TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In a specific embodiment, the isolated nucleic acid comprise SNP associated with T2DM, or the complement of such a SNP, wherein the SNP is at least one SNP associated with a gene that is associated with T2DM, such as a gene selected from the group consisting of TCF7L2, SLC30A8, HHEX (also referred to as HHEX/IDE), TCF2, CXCR4, DARS (also referred to as CXCR4/DARS), ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26,

RAFTLIN and ZNF649. In a further embodiment, the isolated nucleic acid comprises a SNP associated with T2DM, or the complement of such a SNP, wherein the SNP is associated with a gene that is associated with T2DM, such as a gene selected from the group consisting of TCF7L2, SLC30A8, HHEX (also referred to as HHEX/IDE) and TCF2.

The invention encompasses isolated nucleic acid that hybridizes to nucleic acid that comprises a SNP associated with T2DM, such as siRNA, nucleic acids (DNA, RNA) that are useful as probes (e.g., allele-specific probes) for analyzing samples and primers for amplification methods. Such isolated nucleic acid comprises DNA or RNA that hybridizes to a SNP associated with a gene such as, but not limited to, CAMTAl , TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In a specific embodiment, isolated nucleic acid hybridizes to a SNP associated with a gene such as, but not limited to, TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2. The isolated nucleic acids, such as those used as probes or primers, can be conjugated to a detectable marker. Detectable markers include, for example, fluorescent markers, such as fluorescent proteins (e.g., green fluorescent protein, red fluorescent protein, yellow fluorescent protein, blue fluorescent protein), radioactive labels, enzymatic labels, antibodies, a member of a ligand binding pair (e.g., biotin or avidin). The isolated nucleic acids can be of any size appropriate for an intended use, such as any size from a few bases up to and including the whole genome. Further embodiments include an isolated polypeptide encoded by a nucleic acid comprising a SNP associated with T2DM, such as an isolated polypeptide encoded by a nucleic acid comprising a SNP that is associated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl, PEX26 and other T2DM associated SNPs described herein, as well as complements thereof. In specific embodiments, an isolated polypeptide is encoded by nucleic acid comprising a SNP associated with a gene selected from the group consisting of

TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2. Fragments of such polypeptides, such as regions characteristic of the polypeptides that can be used to produce antibodies that specifically recognize a polypeptide encoded by nucleic acid comprising a SNP associated with T2DM (or the complement thereof), are also described herein. Antibodies that bind to a polypeptide encoded by a nucleic acid comprising a SNP associated with T2DM and particularly antibodies that bind preferentially or bind specifically (only) to a polypeptide encoded by a nucleic acid comprising a SNP associated with T2DM are also described. Such antibodies can be made using methods known to those of skill in the art and nucleic acids described herein and can be polyclonal or monoclonal. Of particular interest are mammalian antibodies, such as mouse, human or chimeric (e.g., mouse/human, chimeric, humanized) polyclonal or monoclonal antibodies and fragments thereof.

A further embodiment is a kit for assessing or aiding in assessing whether an individual is at risk for developing T2DM. Such a kit comprises a (at least one, one or more) SNP associated with T2DM (or a complement of the SNP) or nucleic acid (DNA, RNA) comprising a SNP associated with T2DM (or a complement of such a nucleic acid) and, optionally, materials (reagents) for analyzing samples for the alleles of one or more SNPs associated with T2DM, using a method such as sequencing, restriction digestion at polymorphic sites, allele-specific amplification, allele-specific hybridization, allele-specific primer extension, allele-specific ligation or mass spectrometry. Specific embodiments of kits include a risk allele of a SNP associated with T2DM or the complement thereof. For example, the kit comprises at least one SNP or at least one nucleic acid comprising a SNP associated with a gene associated with T2DM, such as CAMTAl₅ TTC13, RYR2, CXCR4, DARS₅ SLC6A20, VPS13A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613,

ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In a specific embodiment, the kit comprises at least one SNP associated with a gene associated with T2DM, such as one of the following: TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, at least one SNP associated with one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2. In further embodiments, the kit comprises nucleic acid (DNA, RNA) that hybridizes to (is complementary to) a SNP described herein. In specific embodiments, a kit comprises at least two SNPs, each associated with a different gene, such as, but not limited to, one of the following: CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26 or at least two nucleic acids that each comprise a SNP associated with a different gene, such as, but not limited to, one of the following: CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl , PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B,

LRRC59, NR5A2, ICAl and PEX26. In specific embodiments, a kit comprises at least two SNPs, each associated with a different gene, such as one of the following: TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2 or at least two nucleic acids that each comprise a SNP associated with a different gene selected from the group consisting of TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, associated with one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2. The kit can include one copy of each SNP associated with a specific gene associated with T2DM or a complement of the SNP. Alternatively, the kit can include multiple copies of each SNP associated with a specific gene or of a complement of the SNP. A kit can further, or alternatively, comprise a complement of any SNP described herein or nucleic acid (DNA, RNA) that is a complement of any SNP described herein.

In one embodiment of the method of assessing or aiding in assessing whether an individual is at risk for developing T2DM, a sample (also referred to as a biological sample) obtained from an individual (e.g., a human) to be assessed for the risk of developing T2DM is analyzed for a SNP that is associated with T2DM; if the risk allele of the SNP associated with T2DM is present in the sample, the individual is (is identified as being) at risk for developing T2DM. In further embodiments, the sample is analyzed for two or more SNPs, each of which is associated with T2DM; if the risk allele for at least one of the T2DM associated SNPs is present in the sample, the individual is at risk for developing T2DM. Those with T2DM have more alleles described herein than individuals who do not have T2DM. Genotypes at two or more alleles permit prediction of T2DM better than genotypes at a single allele. In all embodiments of the method, nucleic acid (DNA, RNA) that is a SNP associated with T2DM can be detected through the use of the SNP, the complement of the SNP, DNA or RNA that comprises the complement of the SNP or a combination of the foregoing.

In this and other embodiments of the method, the SNP is associated, for example, with a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6 A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUR0G3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In specific embodiments of the method, the SNP is associated with a gene selected from the group consisting of TCF7L2,

SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, associated with one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2. In certain embodiments of the method, at least two SNPs associated with T2DM are identified in a sample, such as two or more SNPs, each associated with a different gene, such as, but not limited to one of the following: CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS13A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY,

CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In specific embodiments of the method, each of the two or more SNPs is associated with a different gene, such as but not limited to, one of the following: TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761 , LRRC59, MMP26, NLGN2, NR5A2, PEX26,

RAFTLIN and ZNF649 and, in further specific embodiments, each of the two or more SNPs is associated with one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2.

In specific embodiments, the sample is analyzed for at least one SNP that is associated with TCF7L2 and at least one additional SNP, such as any SNP described herein including at least one SNP that is associated with a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS13A, FAM69B, HHEX, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In a particular embodiment, the sample is analyzed for at least one SNP that is associated with TCF7L2 and at least one SNP associated with a gene selected from the group consisting of SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649. In further specific embodiments, the sample is analyzed for at least one SNP that is associated with TCF7L2 and at least one SNP associated with SLC30A8, HHEX or TCF2.

In further specific embodiments, the sample is analyzed for at least one SNP that is associated with PYY and at least one SNP that is associated with a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In yet further embodiments, the sample is analyzed for at least one SNP that is associated with NEUROG3 and at least one SNP that is associated with a gene selected from the group consisting of CAMTAl , TTCl 3, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, CR592664, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In a particular embodiment of the method of assessing or aiding in assessing whether an individual is at risk for developing T2DM, a sample obtained from an individual to be assessed for the risk of developing T2DM is analyzed for a SNP that is associated with T2DM, wherein the (at least one) SNP is associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS, LDLR, TCF2, ALX4, CAMTAl, EXT2, KIRREL3, LOC387761, LRRC59, NLGN2, NR5A2, PEX26, RAFTLIN, and ZNF649. If the risk allele of the SNP associated with T2DM is present in the sample, the individual is (is identified as being) at risk for developing T2DM. In specific embodiments, the sample is analyzed for at least one SNP that is associated with SLC30A8; at least one SNP that is associated with FGF5; at least one SNP that is associated with CXCR4; at least one SNP that is associated with HHEX; at least one SNP that is associated with RYR2; or at least one SNP that is associated with DARS; at least one SNP that is associated with LDLR; at least one SNP that is associated with TCF2; at least one SNP that is associated with ALX4; at least one SNP that is associated with CAMTA; at least one SNP that is associated with EXT2; at least one SNP that is associated with KIRREL3; at least one SNP that is associated with LOC387761; at least one SNP that is associated with LRRC59; at least one SNP that is associated with NLGN2; at least one SNP that is associated with NR5A2; at least one SNP that is associated with PEX26; at least one SNP that is associated with RAFTLIN; and at least one SNP that is associated with ZNF649A. A combination of these SNPs can also be assessed.

Additional embodiments are methods for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising analyzing a sample obtained from the individual for a SNP or a group of two or more SNPs selected from the group consisting of any of the SNP sequences included herein, such as any one of SEQ. ID No 1-871, wherein if the risk allele of the SNP or the risk allele of one or more of the SNPs is present in the biological sample, the individual is at risk for developing T2DM. For example, one embodiment is a method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising (a) obtaining a sample from the individual; (b) isolating nucleic acid from the biological sample; and (c) analyzing the nucleic acid for at least one SNP that is associated with T2DM, wherein if the risk allele of the at least one SNP is present in the biological sample, the individual is at risk for developing T2DM. This embodiment of the method can comprise sequencing the nucleic acid(s). Analyzing the nucleic acid in (c) can be carried out by means of a hybridization step, which can be carried out in a wide variety of formats, such as in solution or on a surface to which at least one nucleic acid useful in the analysis is affixed. The surface can be, for example, flat or curved and can be, for example, a microarray on a flat or curved surface, such as a chip or a bead. The surface can be glass, plastic or other synthetic material, silicon, or a metal, such as gold and derivatized forms of these substrates. Nucleic acid analyzed can be nucleic acid (DNA, RNA) as obtained from the sample obtained from an individual or can be amplified (e.g., amplified DNA). The method can optionally include an amplification step, in which DNA from the sample is amplified using methods known to those of skill in the art, such as the polymerase chain reaction (PCR).

As mentioned, an individual's risk of developing T2DM can also be assessed by a method in which a sample obtained from an individual is analyzed for a polypeptide encoded by a nucleic acid comprising at least one SNP associated with T2DM, such as a polypeptide encoded by a nucleic acid comprising at least one SNP located in the gene associated with T2DM (e.g., a polypeptide encoded by a nucleic acid comprising at least one SNP located in a coding region of the gene associated with T2DM; a polypeptide encoded by a nucleic acid comprising at least one SNP located in the transcribed region of the gene associated with T2DM; a polypeptide encoded by a nucleic acid comprising at least one SNP located in the non coding region of the gene associated with T2DM or a polypeptide encoded by a nucleic acid comprising at least one SNP located in an intergenic region of the gene associated with T2DM). In one embodiment, the method is a method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising: analyzing a sample obtained from the individual for a polypeptide encoded by a nucleic acid comprising at least one SNP associated with T2DM, wherein if the polypeptide is encoded by a nucleic acid comprising the risk allele of the SNP associated with T2DM, the individual is at risk for developing T2DM. In a further specific embodiment, the method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprises analyzing a sample obtained from the individual for a polypeptide encoded by a nucleic acid comprising at least one SNP associated with T2DM (e.g., a polypeptide encoded by a nucleic acid comprising at least one SNP located in a coding region of a gene associated with T2DM), wherein analyzing comprises comparing the polypeptide to a polypeptide encoded by the allele of the same gene that does not predispose an individual to T2DM and determining if the polypeptides perform differently (e.g., exhibit different functions and/or activity). If the polypeptides perform differently, the individual is at risk for developing T2DM. In the embodiments in which samples are assessed for polypeptides, the assay can be, for example, an enzymatic assay or an antibody binding assay (e.g. ELISA or other antibody-based assay).

Any of the methods of assessing or aiding in assessing whether an individual is at risk for developing T2DM described herein can be carried out in conjunction with additional methods of assessing this risk. For example, a method of the present invention can further comprise performing a fasting plasma glucose test on the individual; performing an oral glucose tolerance test on the individual; determining the fasting serum insulin level of the individual; determining serum C-peptide levels of the individual and any combination thereof.

Also described herein is a method of screening for a therapeutic agent (e.g., a drug) for use in treating T2DM, comprising contacting an agent with a polypeptide encoded by nucleic acid (DNA, RNA) comprising a SNP that is associated with T2DM, and particularly by nucleic acid comprising the risk allele of a SNP associated with T2DM, and determining whether the agent binds to the polypeptide, wherein if the agent binds to the polypeptide, the agent is a candidate therapeutic for treatment of T2DM. In a specific embodiment, the SNP associated with T2DM is located in the coding region of a gene associated with T2DM.

A further embodiment is a method of assessing or aiding in assessing whether an individual with or at risk of developing T2DM will be responsive to treatment for T2DM, comprising: determining a genotype of the individual, wherein the genotype is defined by at least one SNP selected from the group consisting of: SEQ. ID No 1-871, wherein the genotype is indicative of responsiveness to treatment for T2DM. Alternatively, the genotype is defined by at least one SNP associated with a gene associated with T2DM, wherein the gene is selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, CR592664, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. The genotype is determined as to one or more SNPs and then compared with the genotype of individuals known to respond to the treatment. If the genotype of an individual to be assessed (test individual) is substantially the same as that of individuals known to respond to the treatment, it is likely that the individual to be assessed will also respond to the treatment, which can be administered to the test individual and its effects determined. The SNP or SNPs determined for an individual can be one or more SNPs, each of which is associated with a gene associated with T2DM, such as a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS13A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In specific embodiments, the SNP(s) is/are associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS and LDLR. In other embodiments, each SNP is associated with a gene selected from the group consisting of TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, is associated with one of the following genes: TCF7L2, SLC30A8, HHEX and TCF2.

Also described herein is a microarray comprising at least one SNP associated with T2DM, such as at least one SNP selected from the group consisting of SEQ ID NO 1-871. In specific embodiments, the microarray comprises at least one SNP associated with a gene selected from the group consisting of: CAMTAl, TTCl 3, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26. In additional embodiments, the microarray comprises at least one SNP associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS and LDLR. In specific embodiments, the microarray comprises at least one SNP associated with a gene selected from the group consisting of TCF7L2, SLC30A8, HHEX, TCF2,

CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649 and, in further specific embodiments, one of the following genes: TCF7L2, SLC3OA8, HHEX and TCF2. Typically, a microarray will comprise a group of two or more SNP, two or more nucleic acids (e.g., DNA, RNA), each comprising a SNP described herein or nucleic acid that hybridizes to a SNP described herein, such as nucleic acid that is complementary to a T2DM - associated SNP or nucleic acid comprising nucleic acid complementary to a T2DM - associated SNP. In specific embodiments, the nucleic acid is DNA.

BRIEF DESCRIPTION OF THE DRAWING The Figure is a graphic representation of population stratification.

DETAILED DESCRIPTION OF THE INVENTION

This invention pertains to genetic tests and methods of diagnosis of type 2 diabetes mellitus (methods of assessing or aiding in assessing the likelihood an individual will develop/whether an individual is at risk for developing T2DM), as well as to methods of screening for a therapeutic agent, methods of assessing or aiding in assessing whether an individual with or at risk of developing T2DM will be responsive to treatment for T2DM, and reagents, kits and microarrays useful in the methods.

In order to identify T2DM susceptibility loci, Applicants have performed a two- stage, genome- wide association study (GWS) using high-density SNP -based assays. In the study of -400K variants, Applicants identified 76 SNPs that represent T2DM susceptibility loci based on stringent statistical criteria. In addition, Applicants identified more than 800 SNPs that showed a linkage disequilibrium with r² > 0.5 based on data released in build 21 of the International Haplotype Map Project. The work described herein has resulted in localization of disease (T2DM) associated to a particular defined LD (linkage disequilibrium) block. It has also resulted in identification of specific SNPs (T2DM-associated markers) that are useful as predictors of T2DM in individuals (useful to assess or aid in assessing whether an individual is at risk for developing T2DM). Using information provided herein and methods and information publicly available, one of skill in the art can identify new markers, such as polymorphisms/SNPs (T2DM-associated SNPs) within an LD block described herein. Once an LD block has been identified, one of ordinary skill in the art can resequence the region in samples (cases and/or controls) in order to identify/discover additional T2DM- associated polymorphisms (SNPs). This can be done, for example, by resequencing the region/LD block containing the SNP, the region encoding the primary transcript of genes that overlap the region/LD block containing the SNP or regions that contain DNA sequences that control expression or processing of the primary transcript of genes that overlap the region/block containing the SNP. Genes may lie completely within the region/LD block containing the SNP or extend beyond one or both ends of the block. Such SNPs can be shown to be T2DM -associated SNPs by genotyping any new SNP in a small number of DNA samples (cases, controls or both). A person of skill in the art can further assess the SNP for its role/use as a proxy or equivalent of a SNP identified herein (e.g., with reference to one of several statistical indicators, such as r² value).

Such SNPs can be used as predictors of T2DM and possibly, better predictors of T2DM than SNPs identified herein. Additional markers (T2DM-associated SNPs) can be identified, for example, by fine mapping the association described herein within the associated LD block, using known methods. Fine mapping consists of genotyping additional polymorphisms in a large cohort of cases and controls, defining the most highly associated marker, and then determining whether other markers contribute additional effect by conditional regression analysis, using any of a number of publicly available software packages. Additional markers (e.g., SNPs) identified within an LD block described herein (e.g., SNPs whose nearest gene is a gene for which a SNP is identified herein) are considered to be equivalents or obvious variants of the marker(s) (T2DM-associated SNP(s)) described herein. See Supplemental Tables 2 and 3. They are expected to be useful as additional or substitute SNPs or markers in Applicants' methods, kits and microarrays.

The data presented herein confirmed the known association between TCF7L2 SNPs and T2DM (Grant et al., 2006); and also showed association with a SNP

(rs 10823406) located in proximity to the diabetes-associated locus NEUROG3 (Jackson et al., 2004). In addition, the work described herein resulted in the identification of several candidate susceptibility loci that are co-localized with genes implicated in the response to pancreatic injury (CXCR4), in pancreatic development (HHEX), and in β- cell homeostasis (SLC30A8, FGF5 and RYR2). The candidate loci include a non- synonymous SNP (rsl978717) located in ZNF615, as well as 5 additional SNPs situated in a cluster of C2H2-zinc finger transcription factors located on chromosome 19. The invention also identified non-synonymous coding polymorphisms in SLC30A8 (rsl3266634), a β-cell-specific zinc transporter (Chimienti et al., 2004); in MMP26 (rs2499953), a matrix metalloproteinase which is a potential target of wnt/β-catenin (Marchenko et al., 2002); and in FAM69B (rs945384), a protein of unknown function. T2DM-associated SNPs were also found in the introns of RAFTLIN (τs 1262927), a protein associated with peptide hormone signalling (Saeki et al., 2003); in EXT2 a transmembrane endoplasmic reticulum glycoprotein that has been previously linked to T2DM risk (Salonen et al., 2006); in ALX4(rs7949067), a homeodomain protein linked to the function of T-cell transcription factors and wnt signalling (Boras et al, 2002); in VPSlSA (rs2050831), a protein associated with vacuolar and endosomal transport that has been shown to cause choreoacanthocytosis (Rampoldi et al., 2001) (Ueno et al., 2001); in SLC6A20 (rsl3064991), an imino transporter (Takanaga et al., 2005), and in SLC44A3 (rs859101), a choline transporter-like protein (Traiffort et al., 2005); as well as in LDLR (rs6413504, rs5930), a gene whose ablation causes insulin resistance in knockout mice (Merat et al;, 1999) but which has not been associated with changes in insulin sensitivity in humans (Hong et al., 2000). Also identified were T2DM- associated SNPs in proximity to PEX26 (rsl0483096), a gene implicated in Zellweger Syndrome and other disorders of peroxisomal biogenesis (Matsumoto et al., 2003); as well as BTGl (rs35666), a growth-regulatory protein and transcriptional coactivator involved in TCF signalling (Busson et al., 2005) that promotes apoptosis (Lee et al, 2003). Similarly, rs932206 lies adjacent to CXCR4 (involved in pancreatic regeneration (Kayali, 2003)) and DARS, an amino acid synthase that was downregulated in rat INS832/13 cells exposed to glucolipotoxic stimuli. Finally, the data identified association between T2DM and an intronic SNP (rs231461) in PYY, a hormone secreted by the gut and pancreatic islets that has anorectic properties (reviewed in Renshaw et al., 2005) and that enhances insulin action (van den Hoek et al., 2004).

T2DM susceptibility loci can be used for early, presymptomatic detection of the disease and possibly identification of subtypes among phenotypically identical cases that may respond differentially to specific treatments. The association with rsl 111875 is particularly interesting because it maps near a locus that has been previously identified in T2DM in whole-genome linkage studies (Duggirala et al., 1999) (Ghosh et al., 2000) (Wiltshire et al., 2001) (Meigs et al., 2002). This SNP is located in an LD block that includes HHEX, a homeobox transcription factor essential for hepatic and pancreatic development (Bort et al., 2004) (Bort et al., 2006). While the signalling pathways transduced by HHEX during pancreatic development are not well defined, HHEX has been shown to act in concert with BMPs, FGFs, WNTs and eIF4e in other cell contexts. The association between HHEX and the WNT signalling pathway is particularly interesting because TCF7L2, the strongest T2DM susceptibility locus identified to date, is also a downstream target of WNT. This LD block also contains IDE, whose KO results in glucose intolerance (Farris et al., 2003) and which has been associated with beta-amyloid accumulation in Alzheimer's disease brains (Bjork et al., 2006). In addition, QTL studies have demonstrated that IDE polymorphisms influence fasting insulin levels in humans (Gu et al., 2004). While SNPs located within the IDE transcriptional unit showed weak (Groves et al., 2003) (Karamohamed et al., 2003) or no association (Florez et al., 2006) with T2DM, fine mapping of the IDE-KIFl 1 -HHEX locus will be required to identify the causative SNP.

Statistics To determine whether SNPs are useful in evaluating T2DM, numerous statistical analyses can be performed. Allele frequencies, Hardy- Weinberg equilibrium statistics, and linkage disequilibrium (LD) between SNPs can be calculated. Haplotypes can then be calculated using, for example, an EM algorithm (Excoffier and Slatkin, MoI Biol Evol. 1995 Sep; 12 (S): 921-7). In addition to various parameters such as linkage disequilibrium coefficients, allele frequencies, chi square statistics and other population genetic parameters such as Panmitic indices can be calculated to control for ethnic, ancestral or other systematic variation between the case and control groups.

Sequence variation and SNPs In one aspect of the invention the genotype of an individual is determined by analyzing the nucleotide sequence of at least one region of the genome. The term "sequence variation" refers to at least one nucleotide in a nucleic acid which is different in chromosomes of different individuals. Sequence variations include, but are not limited to, base pair substitutions, insertions, deletions, and variable-number repeats. The two DNA copies, which are identical to one another except at the variable position, are referred to. as alleles. A risk allele for a specific disease or ailment is defined as an allele that is most common in people with that specific disease or ailment. An individual can have zero risk allele when the individual is homozygous for one of the alleles most common in people who do not have the specific disease or ailment. An individual can also have one risk allele (heterozygous for the risk allele) or two risk alleles (homozygous for the risk allele).

A "polymorphic region" is a region or segment of DNA which varies from individual to individual. A polymorphism is allelic because some members of a species carry one allele and other members carry a variant allele. When only one variant sequence exists, a polymorphism is referred to as a diallelic polymorphism. There are three possible genotypes in a diallelic polymorphic DNA. These three genotypes arise because it is possible that the DNA may be homozygous for one allele, homozygous for the other allele or heterozygous.

As used herein, a nucleic acid molecule that contains one or more sequence variations is a "sequence variant". Sequence variants are provided herein which include single allelic variants and sequences with more than one sequence variation that are genetically linked (e.g. haplotype). The term "haplotype" includes more than one sequence variation within a single gene or within a set of linked genes. Thus, the term "haplotype", as used herein, refers to an ordered combination of alleles in a defined genetic region that co-segregate. Such alleles are said to be "linked." The alleles of the haplotype may be within a gene, between genes, or in adjacent genes or chromosomal regions that co-segregate with high fidelity. The term "linkage" refers to the degree to which regions of a nucleic acid are inherited together. DNA on different chromosomes are inherited together 50% of the time and do not exhibit linkage. The term "linkage disequilibrium" refers to the co-segregation of two alleles at linked loci such that the frequency of the co-segregation of the alleles is greater than would be expected from separate frequencies of occurrence of each allele. Additional SNPs that are proxies for or equivalent of T2DM-associated SNPs disclosed herein can be identified using the information provided herein and methods known to those of skill in the art. A proxy or equivalent T2DM-associated SNP is, for example, a SNP within an LD block described herein that is sufficiently close to a T2DM-associated gene that it is useful to identify those at risk for developing T2DM. For example, a proxy or equivalent for a T2DM- associated SNP described herein can be a SNP whose nearest gene is a T2DM- associated gene, such as those described herein (e.g., CAMTAl, TTC 13, RYR2, CXCR4, DARS (also referred to herein as CXCR4/DARS), SLC6A20, VPS 13 A, FAM69B, HHEX (also referred to herein as HHEX/IDE), TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26). A specific embodiment of a SNP that is a proxy or equivalent of a T2DM-associated SNP described herein is a SNP for the functional variant of a T2DM-associated gene.

Amplification methods The presence or absence of the sequence variation in a nucleic acid molecule may be determined, for instance, with amplification methods which include, but are not limited to: direct RNA amplification, reverse transcription of RNA to cDNA, real-time (RT)-PCR, amplification of cDNA, anchor PCR, RACE PCR, and LCR (ligation chain reaction), etc. The amplification may be a preliminary step performed in order to increase the number of nucleic acid molecules to be further analyzed. For instance, amplification can be combined with subsequent separation or detection procedures such as gel electrophoresis, capillary gel electrophoresis, mass spectrometry, and HPLC.

Genotyping The genotype of an individual for a part of the genome, a single gene, or set of genes can be determined with any of a number of methods that are well known to those of skill in the art. Genotyping includes analyzing a nucleic acid for SNPs. The genotype of the individual can be determined, for instance, using any standard sequencing or sequence analysis techniques. Examples of such techniques are described in Cotton, R.G.H., Mutation Detection, Oxford University Press, 1998. Some sequencing or sequence analysis techniques include direct sequencing, minisequencing, pyrosequencing (Ronaghi, et al., Science,28l, 1998), PCR primer mismatch, single-base extension, restriction fragment length polymorphism, single stranded conformational analysis, and ligation assays in addition to a variety of other amplification and hybridization techniques.

For example, the genotyping can be performed using a SEQUENOM MassARRA Y Matrix Assisted Laser Desorption and Ionization Time of Flight (MALDI-TOF) mass spectrometer (Sequenom, San Diego, CA). SEQUENOM MALDI-TOF mass spectrometer allows the analysis of unlabeled single-base extension minisequencing reactions. Primers for use in these minisequencing reactions can be designed with a variety of methods known in the art, including the semi-automated primer design program (Spectro DESIGNER, Sequenom). In this embodiment, very short extension method (VSET) (Sun et al., Nucleic Acids Res 2000, 28: E68) can be used to extend sequencing products by only one base for 3 or 4 nucleotides (due to the presence of dideoxynucleotides for 3 of the 4 nucleotides in the minisequencing reaction) and by several additional bases for the fourth nucleotide which are specified in advance to represent one of the two alleles at a given SNP locus. The allelic variants are then distinguished by mass separation with MALDI-TOF.

In one particular commercial example of a method that can be used to identify a nucleotide occurrence of one or more polymorphisms, the identity of the nucleotide in gene in a sample can be determined using the SNP-ITTM method (Orchid BioSciences, Inc., Princeton, NJ). In general, SNP-ITTM is a 3-step primer extension reaction. In the first step a target polynucleotide is isolated from a sample by hybridization to a capture primer, which provides a first level of specificity. In a second step the capture primer is extended from a terminating nucleotide trisphosphate at the target SNP site, which provides a second level of specificity. In a third step, the extended nucleotide trisphosphate can be detected using a variety of known formats, including: direct fluorescence, indirect fluorescence, an indirect colorimetric assay, mass spectrometry, and fluorescence polarization. Reactions can be processed in 384 well format in an automated format using a SNP stream instrument (Orchid BioSciences, Inc., Princeton, NJ).

Hybridization procedures

The detection of sequence variants including SNPs can also be performed with any of a number of specific hybridization procedures well known in the art. A Southern blot may be performed using the foregoing conditions, together with a detectably labeled probe (e.g. radioactive, chemiluminescent or fluorescent probes). After washing the membrane to which the DNA is finally transferred, the membrane can be placed against X-ray film or analyzed using a phosphorimager device to detect the radioactive, fluorescent or chemiluminescent signal. Northern blot hybridizations using the foregoing conditions can also be performed on samples taken from subjects suspected of having or diagnosed as having a disease, such as diabetes, heart disease, COPD or asthma. Other hybridization techniques include FISH (fluorescent in situ hybridization), dot blot, slot blot analyses and microarrays. Hybridization

As used herein, probes which hybridize to a sequence variant do so under sufficient hybridizing conditions. It is within the knowledge of one of skill in the art to be able to determine the hybridizing conditions necessary to detect one or more sequence variants in a sample. In one embodiment, the probe hybridizes to the sequence variant under low or medium stringent conditions. In certain embodiments, the probe hybridizes under highly stringent conditions. The term "stringent conditions" as used herein refers to parameters with which the art is familiar. Such parameters include salt, temperature, length of the probe, etc. The amount of resulting base mismatch upon hybridization can range from about 0% ("high stringency") to about 30% ("low stringency"). Nucleic acid hybridization parameters may be found in references such as Molecular Cloning: A Laboratory Manual, J. Sambrook, et al., eds., Second Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989 and Current Protocols in Molecular Biology, F.M. Ausubel, et al., eds., John Wiley & Sons, Inc., New York. One example of high-stringency conditions is hybridization at 65⁰C in hybridization buffer (3.5X SSC, 0.02% Ficoll, 0.02% polyvinyl pyrrolidone, 0.02% Bovine Serum Albumin, 2.5mM NaH2PO4(pH7), 0.5% SDS, 2mM EDTA). SSC is 0.15M sodium chloride/0.15M sodium citrate, pH7; SDS is sodium dodecyl sulphate; and EDTA is ethylenediaminetetracetic acid. After hybridization, a membrane upon which the nucleic acid is transferred is washed, for example, in 2X SSC at room temperature and then at 0.1 - 0.5X SSC/0.1X SDS at temperatures up to 68°C.

A "probe" as used herein is any compound which specifically interacts with and identifies a sequence variation. For instance, a probe may be a nucleic acid, such as a complementary nucleic acid molecule, a protein or a peptide nucleic acid (PNA) molecule. The probes may be specific for a nucleotide sequence that contains a single sequence variation, or may specifically hybridize to a nucleotide sequence that contains 2, 3, 4, 5 or more sequence variations. One or more probes may be used to identify multiple sequence variations. For instance, one or more probes may specifically hybridize to a region of a nucleic acid molecule that indicates a haplotype. A set of probes may be used which are capable of hybridizing to more than one sequence variant in one or more genes. The probes may be of any length to specifically detect the sequence or sequences of interest. Nucleic acid probes are selected from the group of nucleic acids including, but not limited to: DNA, genomic DNA, cDNA, and oligonucleotides they may be natural or synthetic. Oligonucleotide probes vary in size according to the context in which they are used and often are from about 20 to 25-mer oligonucleotides. DNA/cDNA probes can be a variety of lengths as well, such as from about 500 to 5000 bases in length, although other lengths may be used. In specific embodiments, the probes are about 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, or more nucleotides in length. Appropriate probe length may be determined by one of ordinary skill in the art by following art-known procedures. Probes may be purified to remove contaminants using standard methods known to those of ordinary skill in the art such as gel filtration or precipitation. The probe or set of probes may optionally be attached to a solid substrate.

Microarray

Another hybridization technique makes use of nucleic acid microarrays. Nucleic acid microarray technology, which is also known by other names, including DNA chip technology, gene chip technology, and solid-phase nucleic acid array technology, is well known to those of ordinary skill in the art and is based on, but not limited to, obtaining an array of identified nucleic acid probes on a fixed substrate, labeling target molecules with reporter molecules (e.g., radioactive, chemiluminescent, or fluorescent tags such as fluorescein, Cye3-dUTP, or Cye5-dUTP), hybridizing target nucleic acids to the probes, and evaluating target-probe hybridization. A probe with a nucleic acid sequence that perfectly matches the target sequence will, in general, result in produce a stronger reporter-molecule signal than will probes with less perfect matches. The probes can be attached to a variety of functional and structural surfaces, including, a chip, a bead, a slide, glass surfaces, plastic surfaces, flat surfaces and curved surfaces. Many components and techniques utilized in nucleic acid microarray technology are presented in The Chipping Forecast, Nature Genetics, Vol.21, Jan 1999, the entire contents of which are incorporated by reference herein.

Microarrays also encompass bead arrays, in which nucleotide probes are attached to beads. Commercial examples of this technique are the Illumina Infinum Human 1 and Hap300 arrays (Illumina, San Diego, CA).

Targets for microarrays include proteins or nucleic acids including but not limited to DNA, genomic DNA, cDNA, RNA, mRNA; these may be natural or synthetic. In some embodiments of the invention, one or more control nucleic acid molecules are added to a biological sample. Control nucleic acid molecules allow determination of factors such as nucleic acid quality and binding characteristics, reagent quality and effectiveness, hybridization success, and analysis thresholds and success. Control nucleic acids may include but are not limited to expression products of genes such as housekeeping genes or fragments thereof.

Detection and identification of hybridized probes can also be determined with analytical separation techniques such as those listed above. In some embodiments, MALDI-TOF mass spectrometry is used. The use of MALDI-TOF to separate peptide nucleic acid (PNA) probe hybridization products has been described (Ross, et al., Anal. Chem., 69 (20):4197-202, 1997). In other embodiments, capillary electrophoresis is used for probe hybridization product separation (Basile, et al., Electrophoresis, 23 (6), 2002).

Sample

As used herein, the terms "sample" and "biological sample" are used interchangeably and include but are not limited to: tissue, cells, or body fluid (e.g. serum, blood, lymph node fluid). The fluid sample may include cells and/or fluid. The tissue and cells may be obtained from a subject or may be grown in culture (e.g. from a cell line).

Samples used in the methods described herein may comprise cells from the eye, epidermis, epithelium, blood, tears, saliva, mucus, urine, stool, sperm, ova, or any other tissues or bodily fluids from which sufficient DNA or RNA can be obtained. In a specific embodiment, cells obtained from a buccal swab are used. The sample should be sufficiently processed to render DNA or RNA present available for assaying in the methods described herein. For example, samples may be processed such that DNA from the sample is available for amplification by DNA polymerases or other enzymes that increase the total DNA content or for hybridization to another polynucleotide. The processed samples may be crude lysates where available DNA or RNA is not purified from other cellular material, or may be purified to specifically isolate DNA or RNA. Samples may be processed by any means known in the art that renders DNA or RNA available for assaying in the methods described herein. Methods for processing samples may include, without limitation, mechanical, chemical, enzymatic, or molecular means of lysing and/or purifying cells and cell lysates. Processing methods may include chromatographic methods such as ion exchange (e.g., cation and anion), size exclusion, affinity, and hydrophobic interaction chromatography.

Isolated nucleic acids In another aspect of the invention isolated nucleic acid molecules are provided.

These nucleic acid molecules may contain one or more SNPs associated with T2DM. For example, isolated nucleic acid molecules are provided which are selected from the following sequences: SEQ ID NOs: 1-76 and fragments thereof. In other instances the isolated nucleic acid molecules are selected from the following sequences: SEQ ID NOs: 76-871 risk alleles and fragments thereof. Fragments of the isolated nucleic acid molecules are provided which include portions of the nucleotide sequences which contain one or more sequence variations including SNPs as described herein. Fragments, for example, are long enough to assure that the presence or absence of the precise sequence indicates the presence or absence of a sequence variant of interest. The sequence variant of interest can be a single allelic variant or a haplotype. Those of ordinary skill in the art may apply no more than routine procedures to determine if a fragment is of the appropriate size for this purpose. Additionally, the complementary sequences hybridizable to the sequence variants as described above are likewise the subject of the invention. An isolated nucleic acid may be substantially purified, but need not be. For example, a nucleic acid that is isolated within a cloning or expression vector is not pure in that it may comprise only a tiny percentage of the material in the cell in which it resides. Such a nucleic acid is isolated, however, as the term is used herein because it is readily manipulable by standard techniques known to those of ordinary skill in the art. The term "nucleic acid" is used broadly herein to mean a sequence of deoxyribo nucleotides or ribonucleotides that are linked together by a phosphodiester bond. A nucleic acid can be RNA or can be DNA, which can be a gene or a portion thereof, and can be single stranded or double stranded, as well as a DNA/RNA hybrid. In various embodiments, a nucleic acid can contain nucleoside or nucleotide analogs, or a backbone bond other than a phosphodiester bond. In general, the nucleotides comprising a nucleic acid or polynucleotide are naturally occurring deoxyribonucleotides, such as adenine, cytosine, guanine or thymine linked to 2'-deoxyribose, or ribonucleotides such as adenine, cytosine, guanine or uracil linked to ribose. However, a nucleic acid also can contain nucleotide analogs, including non-naturally occurring synthetic nucleotides or modified naturally occurring nucleotides. Such nucleotide analogs are well known in the art and commercially available, as are polynucleotides containing such nucleotide analogs (Lin et al., Nucl. Acids Res. 22: 5220-5234(1994); Jellinek et al., Biochemistry 34: 11363-11372 (1995); Pagratis et al., Nature Biotechnol. 15:68-73 (1997), each of which is incorporated herein by reference).

The covalent bond linking the nucleotides of a nucleic acid generally is a phosphodiester bond. However, the covalent bond also can be any of numerous other bonds, including a thiodiester bond, a phosphorothioate bond, a peptide-like bond or any other bond known to those in the art as useful for linking nucleotides to produce synthetic polynucleotides (see, for example, Tarn et al., Nucl. Acids Res. 22: 977-986 (1994); Ecker and Crooke, BioTechnology 13:351360 (1995), each of which is incorporated herein by reference). The incorporation of non-naturally occurring nucleotide analogs or bonds linking the nucleotides or analogs can be particularly useful where the polynucleotide is to be exposed to an environment that can contain a nucleolytic activity, including, for example, a tissue culture medium or upon administration to a living subject, since the modified nucleic acids can be less susceptible to degradation. A nucleic acid comprising naturally occurring nucleotides and phosphodiester bonds can be chemically synthesized or can be produced using recombinant DNA methods, using an appropriate nucleic acid as a template. In comparison, a nucleic acid comprising nucleotide analogs or covalent bonds other than phosphodiester bonds generally are chemically synthesized, although an enzyme such as T7 polymerase can incorporate certain types of nucleotide analogs into a polynucleotide and, therefore, can be used to produce such a nuclei acid recombinantly from an appropriate template (Jellinek et al., supra, 1995). Thus, the term nucleic acid as used herein includes naturally occurring nucleic acid molecules, which can be isolated from a cell, as well as synthetic molecules, which can be prepared, for example, by methods of chemical synthesis or by enzymatic methods such as by the polymerase chain reaction (PCR). Polypeptide

Also described herein are methods for assessing the risk of an individual to T2DM or development for T2DM by analyzing the presence or absence of a polypeptide encoded by a sequence variant including SNPs described herein. The methods may also be accomplished using the mutant polypeptides (including whole proteins and partial proteins) that are encoded by the sequence variants described herein. Such mutant polypeptides are useful, for example, alone or as fusion proteins to generate antibodies, and as components of a diagnostic assay. Mutant polypeptides can be isolated from biological samples including tissue or cell homogenates, and can also be expressed recombinantly in a variety of prokaryotic and eukaryotic expression systems by constructing an expression vector appropriate to the expression system, introducing the expression vector into the expression system, and isolating the recombinantly expressed mutant protein. Fragments of the mutant polypeptides also can be synthesized chemically using well-established methods of peptide synthesis. Polypeptides encoded by nucleic acids that comprise T2DM-predisposing sequence variants including SNPs can be compared to control polypeptides encoded by nucleic acids that do not have the sequence variants. Comparisons between polypeptides can be performed with both functional and structural assays. Non-limiting examples of functional assays are antibody binding assays and enzymatic assays. The invention further includes protein microarrays (including antibody arrays) for the analysis of mutant polypeptides encoded by nucleotide sequences comprising one or more SNPs. Protein microarray technology, which is also known by other names including protein chip technology and solid-phase protein array technology, is well known to those of ordinary skill in the art and is based on, but not limited to, obtaining an array of identified peptides or proteins on a fixed substrate, binding target molecules or biological constituents to the peptides, and evaluating such binding. See, e.g., G. MacBeath and S. L. Schreiber, "Printing Proteins as Microarrays for High-Throughput Function Determination," Science 289(5485):1760-1763, 2000.

siRNA

The term "small interfering RNA" or "siRNA," as used herein, refers to a RNA molecule derived from the successive cleavage of long double-stranded RNA (dsRNA) within a cell to produce an RNA molecule generally have a length of between 15 and 30 nucleotides, and more often between 20 and 25 nucleotides. siRNAs direct the destruction of corresponding mRNA targets during RNA interference in animals, and during other RNA-silencing phenomena, including posttranscriptional gene silencing of plants and quelling of Neurospor a.

The methods for design of the RNAs that mediate RNAi and the methods for transfection of the RNAs into cells and animals are well known in the art and are readily commercially available (Verma N.K. et al, J. Clin. Pharm. Ther., 28(5):395-404(2004), Mello CC. et al. Nature, 431(8716)338-42 (2004), Dykxhoorn D.M. et al., Nat. Rev.Mol. Cell Biol. 4(6):457-67 (2003) Proligo (Hamburg, Germany), Dharmacon

Research (Lafayette, CO, USA), Pierce Chemical (part of Perbio Science, Rockford, IL , USA), Glen Research (Sterling, VA, USA), ChemGenes (Ashland, MA, USA), and Cruachem (Glasgow, UK)). The RNAs are preferably chemically synthesized using appropriately protected ribonucleoside phosphoramidites and a conventional DNA/RNA synthesizer. siRNAs can be obtained from commercial RNA oligo synthesis suppliers. In general, RNAs are not too difficult to synthesize and are readily provided in a quality suitable for RNAi. A typical 0.2 μmol-scale RNA synthesis provides about 1 milligram of RNA, which is sufficient for 1000 transfection experiments using a 24-well tissue culture plate format. Any RNA can be used in the methods of the present invention, provided that it has sufficient homology to the nucleic acid comprising the SNPs to mediate RNAi. There is no upper limit on the length of the RNA that can be used. For example, the RNA can range from about 21 base pairs (bp) of the gene to the full length of the gene or more. In one embodiment, the RNA used in the methods of the present invention is about 1000 bp in length. In another embodiment, the RNA is about 500 bp in length. In yet another embodiment, the RNA is about 22 bp in length. In certain embodiments the preferred length of the RNA of the invention is 21 to 23 nucleotides.

Kits for diagnostics In addition to the methods, kits are also provided that are useful for assessing or aiding in assessing whether an individual is at risk for developing T2DM. One embodiment of a kit of the invention is a kit that provides components necessary to determine the presence or absence of one or more sequence variants including SNPs of the invention. Such components include probes that hybridize to the sequence variants of the invention, such as, for instance, nucleotide sequences set forth as SEQ 1-871 (see Supplemental Table 2) and fragments thereof, wherein the fragment contains a sequence variation.

Another example of a kit includes components such as primers useful for amplification of one or more sequence variants and/or other chemicals for PCR amplification. The primers are constructed and arranged to selectively amplify a region of a nucleic acid molecule that is suspected of containing one or more sequence variations. It is within the skill of the art to construct and arrange primers necessary to assess the genotype of a subject.

The kits provided can also, optionally, contain one or more control agents. The kits also may contain instructions for using the probes/primers of the invention and to correlate the hybridization/amplification to the risk of an individual for developing T2DM.

T2DM diagnostics

Diabetes is a well characterized disease (See e.g. information available from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)). Diabetes can be categorized into two main types: Type I diabetes and Type 2 Diabetes. Type 2 Diabetes mellitus (T2DM) is also referred to as adult-onset diabetes or non-insulin dependent diabetes mellitus. T2DM is currently diagnosed with a variety assays. Non- limiting examples of diagnostic assays for T2DM are the "fasting plasma glucose test" and the "oral glucose tolerance test", which are known to persons of ordinary skill in the art. Other embodiments of diagnostic tests are the determination of fasting serum insulin levels and serum C-peptide levels. These diagnostic tests are also known to people of ordinary skill in the art.

The diagnostic serum level and tolerance tests described above can be used in conjunction with SNP analysis methods described herein for assessing or aiding in assessing individuals at risk for T2DM, including association and linkage disequilibrium methods, described below.

The present invention is further illustrated by the following Examples, which in no way should be construed as further limiting. The entire teachings of all of the references (including literature references, issued patents, published patent applications, and co-pending patent applications) cited throughout this application are hereby expressly incorporated by reference.

EXEMPLIFICATION

Overview of experiments

A two-stage strategy was used to perform a cost-effective GWS without sacrificing statistical power.

Stage 1

In the first stage, Illumina Infinium Human 1 and Hap300 (Ilumina, San Diego, CA) arrays were used to obtain genotypes for 689 (Hap300: 694) T2DM patients (sex ratio: 418 m. / 272 f, mean age at diagnosis: 44.9 ± 8.4 yr., mean age at exam: 59.9 ± 10.4 yr., mean BMI: 25.8 ± 2.8 kg/m²) and 670 (Hap300: 654) control subjects (sex ratio: 264 m. / 406 f, mean age at exam: 53.4 ± 5.6 yr., mean BMI: 23.2 + 1.8 kg/m²). The subjects were all unrelated French Caucasians. Inclusion criteria for affected individuals were (i) T2DM according to 1997 American Diabetes Association (ADA) criteria; (ii) familial history of diabetes in first degree relatives; (iii) BMI < 30 kg/m². The BMI cut-off was designed to enrich the population for variants determining insulin resistance and β-cell dysfunction that act independent of obesity. Diabetic subjects were recruited at the UMR8090 CNRS unit in Lille (N=260) and at the Endocrinology- Diabetology Department of the Corbeil-Essonnes Hospital (N=430). Inclusion criteria for control subjects were; (i) age at exam > 45 yr.; (ii) normal glucose tolerance according to 1997 ADA criteria; (iii) BMI < 27 kg/m². The control subjects were participants in the Data from an Epidemiological Study on the Insulin Resistance syndrome (DESIR.) program (a 9-year longitudinal study that aims to clarify the development of the insulin resistance syndrome) and came from 10 health examination centers in the western central part of France (Balkau, 1996). All participants signed an informed consent and the protocol was approved by the French ethics committee. The study subjects were selected to optimize Stage 1 power by including patients with at least one affected first degree relative, to enrich for risk alleles (Fingerlin, 2004). In addition, cases were selected for BMI < 30 kg/m², to enrich for variants determining insulin resistance and β-cell dysfunction through mechanisms other than obesity and controls had fasting blood glucose levels in the lower tail of the distribution (< 14^th percentile in 9 years of D.E.S.I.R; cohort follow-up). Finally, case- control pairing for BMI should further increase study power. The effect of subject selection on power was estimated with biometric-model simulations. As an example, for a variant with a relative risk of 1.40 and MAF=O.1, power increases from 0.5 (as per Applicants' mid-term report, Skol et al., 2006) to at least 0.9.

Genome analysis

Genomic DNA was extracted from peripheral blood cells using PURE-GENE D50K DNA isolation kits (Gentra Systems; Minneapolis, MN) or DNeasy Blood & Tissue Kit (Qiagen, Germantown, MD). Genotypes were obtained for each study subject using two SNP-based platforms: a) Illumina Infinium Humanl BeadArrays, which assay 109,375 SNPs chosen using an exon-centric design based on genes identified in RefSeq, Ensembl and Swiss-Prot; and b) Human Hap300 BeadArray, which assay 317,503 SNPs chosen to tag haplotype blocks identified by the Phase I HapMap (International HapMap Consortium, 2005). Samples successfully genotyped for fewer than 90% of the markers on each BeadArray were excluded from further analysis. On average, genotypes were obtained for 99.2% (Humanl) and 99.4% (Hap300) of loci assayed for each subject with a reproducibility of >99.9% (both platforms). Markers that deviated significantly from Hardy- Weinberg equilibrium (HWE) (p < 0.001 in the control samples), that had low MAF (<0.01 in both the case or control samples), or that had a call rate <95% in the case and control samples combined, were excluded from further analysis. In total, Applicants analyzed genotypes for 100,996 (Humanl) and 309,776 (Hap300) SNPs representing 393,736 unique loci.

Stratification analysis

To identify possible population stratification within the study population, case and control genotypes were analyzed using STRUCTURE (Pritchard et al. 2000). This program uses genotype information from each individual (without indication of its geographical origin) and assigns them to inferred populations by minimizing both the linkage disequilibrium between unlinked loci and the deviation from Hardy- Weinberg equilibrium within each population. Each individual is assigned to one or more populations with different "coefficients of ancestry" (between 0 and 1, the sum of the coefficients being equal to 1). In order to increase the power to discriminate individuals from different geographical origins and to obtain a quick assessment of the ancestry of potential outliers, Applicants included unrelated individuals from three populations genotyped by the HapMap project. When the data set was analyzed, most cases and controls fell within the range of the CEPH individuals from the HapMap, consistent with their European origin. However, 52 individuals lay outside the CEPH cluster and were excluded from the association study (Figure). The Figure shows population stratification in this study compared to control.

Cohorts were identified and corrected using STRUCTURE (Pritchard et al. 2000), which was run with parameters that allow for admixture and that force the allele frequencies in the different populations to be correlated (prior to the computation). Three independent runs, consisting of 30,000 burn-in steps followed by 100,000 Markov Chain Monte Carlo steps were obtained for a model based on four populations. The three runs converged to a single solution with very similar coefficients of ancestry for each individual. In order to increase the power to discriminate individuals from different geographical origins, Applicants performed stratification analysis using SNPs spaced by at least 5 Mb and with Fsts greater than 0.200 based on the Perlegen dataset (Hinds et al, 2005) to. Unrelated individuals from three populations genotyped by the HapMap project (60 CEPH from Utah (CEU), 60 Yoruba (YRI) and 89 Han Chinese /Japanese (CHB/JPT)) were also included. This will better separate individuals according to their continental origin, since the allele frequencies for the non-European populations will be estimated using at least 60 individuals. The data set consisted of 1619 individuals (736 cases, 674 controls and 209 individuals from the HapMap) and their genotypes at 328 SNPs. When the data set was split into three populations, the assignment of the HapMap individuals corresponded to their geographic origin, with each individual belonging to one population with a coefficient of ancestry larger than 0.90. While most cases and controls fell within the range of the CEPH individuals from the HapMap, Applicants identified 43 individuals who lay outside the CEPH cluster. No differences between the assignment of cases and controls could be detected after removal of these outliers. T2DM association

T2DM association was tested with Armitage's trend test as well as dominant and recessive models for autosomal SNPs (Sasieni, 1997). To maximize study power, Applicants examined the strongest association obtained from the three models. Genome- wide significance values were obtained using 10,000 permutations of the case-control labels under the null hypothesis and evaluating the test statistic against the combined distribution of all SNPs. Subtle subpopulation structure or systematic genotyping errors can give rise to variance inflation for the measured test statistics and a deviation from the expected χ²(l) distribution (Devlin et al., 1999) (Reich et al., 2001) (Clayton et al., 2005) (Kohler et al., 2005). To correct this, Applicants estimated the variance inflation factor by taking the ratio between the mean of the measured statistic and the mean of the expected one for the SNPs with the lowest 90% of the measured statistic (Clayton et al., 2005) and used this to correct the observed χ² statistic. The adjusted Quantile-Quantile plots (QQ-plots) show a distribution of p- values that better align with the expected uniform distribution. Using these QQ-plots to estimate empiric significance thresholds for the MAX model (which uses the maximum of the measured χ² statistics for the additive, dominant and recessive models), Applicants identified 29 autosomal SNPs that demonstrated association at p < 1 x 10^"4 on the Human 1 chips (Table 1) and 42 autosomal SNPs that demonstrated association at p < 5 x 10^"5 on the Hap300 chips (Table 2). The sex-chromosome SNPs were analyzed separately by applying the

Armitage trend test to the full set of samples as well as to genotypes from females and males separately. Two SNPs passed the 1 x 10^"4 threshold, having observed p-values of 4.5 x 10-⁸ (rsl635250, located in an intron of MXRA5) and 3.7 x 10^"4 (rs5984618, located in an intergenic region) for the dominant model. In addition, Applicants identified seven SNPs in strong T2DM functional loci that showed association at lower significance levels, including two wnt-pathway members (TCF2, rs7405696, p= 1.2 x 10^"4; WNT8B, rsl 1190578, p= 6.9 x 10^"5), a TNFα-associated protein (LRRC59, rs7211667, p= 8.9 x 10^"5), a nuclear receptor (NR5A2, rsl0494809, p= 8.5 x 10^"5) that is regulated byPDXl (Annicotte et al., 2003); an islet cell antigen (ICAl, rsl0282493, p= 1.5 x 10-⁴) found in TlDM patients; a growth factor (FGF5, rslOOO6753, p= 6.3 x lO^"6) whose receptor has been linked to T2DM in mice (Hart et al., 2000); and a lipoprotein receptor (LDLR, rs5930, p= 1.8 x 10^"5) whose ablation causes insulin resistance in knockout mice (Merat et al., 1999).

As rs932206 maps to a region displaying positive selection, very close to the "lactase SNP" (Campbell et al., 2005), Applicants tested for population structure or geographic MAF gradient that could cause spurious association. Principal Component Analysis was performed on markers, with the first four PCA axes used as covariate for each individual. The association between rs932206, disease status and these covariates was re-tested through logistic regression. The T2DM association remained highly significant. Moreover, the first PCA axis explained slightly over 1/871 of the variance (0.0002) which confirms absence of significant evidence of residual population structure.

Supplementary Table 2 provides a summary of all linkage disequilibrium SNPs identified in this study.

TABLE 1: T2DM Associated SNPs identified using Human 1 BeadArrays.

pMAX OR OR

SNP Chr Position Model Gene (Corrected) (Het) (Horn) rs1193179 1 7503868 4.0X 10-⁷ Dominant 1.77 1.64 CAMTA1 rs6541240 1 227397313 2.5X 10^'5 Recessive 1.02 1.61 TTC13 rs6670163 1 233862625 9.8X 10^'6 Recessive 1.02 1.66 RYR2 rs932206 2 136659004 1.4X 10^"6 Recessive 1.01 1.77 CXCR4.DARS rs13064991 3 45809815 1.5X 10⁵ Additive 1.37 2.17 SLC6A20 rs7651936 3 163505661 1.6X 10^"5 Recessive 1.11 1.86 rs282705 4 59343615 2.8X 10^"6 Additive 2.26 3.07 rs2050831 9 77117950 3.5X 10-⁵ Recessive 0.57 0.99 VPS13A rs945384 9 136892579 1.6X 10^"5 Dominant 2.57 3.13 FAM69B rs1111875 10 94452862 2.7X 10^'6 Additive 1.49 2.13 HHEX rs7900150 10 114783813 5.0X 10^"9 Additive 1.54 2.46 TCF7L2 rs7100927 10 114786038 5.0X 10^"9 Additive 1.54 2.46 TCF7L2 rs2499953 11 4967481 9.4X 10^'6 Additive 4.43 n.a. MMP26 rs1113132 11 44209979 1.6X 10-⁵ Dominant 2.72 2.77 EXT2 rs11037909 11 44212190 7.2X 10-⁶ Dominant 2.84 2.85 EXT2 rs3740878 11 44214378 7.2X 10^'6 Dominant 2.85 2.84 EXT2 rs1256517 14 64805437 2.5X 10^'5 Dominant 1.77 1.27 rs 11078674 17 7251197 2.9X 10^"5 Additive 1.36 2.15 NLGN2 rs6413504 19 11102915 2.7X 10^"5 Additive 1.59 1.94 LDLR rs8101509 19 57100638 7.8X 10^'6 Recessive 1.18 2.75 ZNF649 rs919779 19 57130159 3.8X 10^'6 Recessive 1.23 3.25 ZNF613 rs2278419 19 57163625 1.6X 10^"5 Recessive 1.26 2.95 ZNF350 rs11084127 19 57187192 2.3X 10^"6 Additive 1.41 2.52 ZNF615 rs11084128 19 57187458 2.8X 10^'6 Additive 1.39 2.56 ZNF615 rs1978717 19 57189062 1.5X 10^"6 Additive 1.44 2.53 ZNF615 rs1836002 19 57190334 3.5X 10^'6 Additive 1.41 2.46 ZNF615 rs10211998 22 35569377 1.6X 10^"5 Recessive 1.08 1.75 FLJ90680 rs5756371 22 35569520 2.0X 10 ^s Recessive 1.13 1.80 FLJ90680 rs873492 22 44818409 4.6X 10^'5 Dominant 1.57 1.56 FLJ27365 rs1635250 X 3235152 4.5X 10^"8 Dominant 2.17 2.42 MXRA5 rs5984618 X 90079719 3.7X 10^"4 Dominant 1.67 1.96

TABLE 2: T2DM Associated SNPs identified using Hap30θ Bead Arrays.

pMAX OR OR

SNP Chr Position Model Gene (Corrected) (Het) (Horn) rs1193179 1 7503868 2.5X 10^"6 Dominant 1.67 1.79 CAMTA1 rs2317948 1 55146464 3.9X 10^"6 Dominant 2.26 2.38

ΓS859101 1 95036805 4.9X 10^"6 Dominant 1.71 1.64 SLC44A3

ΓS11249433 1 120892655 1.5X 10^"5 Dominant 1.85 1.95 LOC642123 rs932206 2 136659004 1.5X 10^"7 Recessive 0.99 1.85 CXCR4.DARS rs1037386 3 1453453 2.2X 10^"6 Dominant 2.32 2.09 rs 12629276 3 16403485 5.0X 10^-6 Additive 1.52 2.39 RAFTLIN rs9290240 3 165780254 4.9X 10⁶ Additive 1.59 1.98 rs282705 4 59343615 3.4X 10^"6 Additive 2.38 3.19 rs2866016 4 99861413 3.6X 10^~6 Additive 1.77 2.48 TSPAN5 rs6823091 4 153427388 1.1X 10^"5 Additive 1.60 2.27 DB127798 rs7712842 5 144247299 2.1X 10^"6 Recessive 0.91 2.27 rs6894954 5 144294556 1.9X 10⁶ Recessive 0.90 2.27 rs2327112 6 8944645 2.7X 10⁶ Recessive 0.97 1.76 rs10503677 8 20248324 2.6X 10^'5 Dominant 1.63 1.55 rs13266634 8 118253964 7.2X 10^'6 Recessive 0.77 1.31 SLC30A8 rs10823406 10 70982029 1.1X 10^"5 Recessive 1.01 1.65 rs1111875 10 94452862 2.6X 10^"6 Additive 1.52 2.14 HHEX rs7923837 10 94471897 8.6X 10^'7 Additive 1.78 2.38 rs7903146 10 114748339 3.9X 10^'19 Additive 2.33 3.90 TCF7L2 rs7904519 10 114763917 2.2X 10^"11 Additive 1.62 2.83 TCF7L2 rs10885409 10 114798062 1.4X 10^"11 Additive 1.57 2.84 TCF7L2 rs12255372 10 114798892 4.8X 10^"15 Additive 1.92 3.58 TCF7L2 rs4918789 10 114811797 8.3X 10⁷ Additive 1.52 2.13 TCF7L2 rs290483 10 114905204 1.9X 10^"6 Additive 1.47 2.14 TCF7L2 rs7480010 11 42203294 8.5X 10^"6 Dominant 1.60 1.77 LOC387761 rs729287 11 44236666 9.0X 10-⁶ Dominant 2.77 2.80 rs7949067 11 44248060 7.6X 10^'6 Dominant 1.76 1.78 ALX4 rs7950175 11 126033245 7.1X 10-7 Recessive 1.18 2.01 KIRREL3 rs35666 12 91036838 1.1X 10^'6 Dominant 1.90 1.87 BTG 1 rs2876711 13 76314505 9.3X 10^"6 Recessive 1.12 1.83 rs1256526 14 64809658 3.4X 10^"6 Dominant 1.69 1.75 rs2589001 16 53776363 2.7X 10^"6 Additive 1.39 2.09 rs231461 17 39388569 1.7X 10^'6 Dominant 1.82 2.11 PYY rs1005316 17 66501964 9.6X 10^"6 Dominant 3.59 3.88 rs2288887 19 57187615 4.6X 10^"6 Additive 1.42 2.38 ZNF615 rs1978717 19 57189062 4.3X 10^'6 Additive 1.43 2.38 ZNF615 rs1293144 20 52350615 8.8X 10^'6 Recessive 1.09 1.83 rs1293143 20 52351866 6.3X 10^"6 Recessive 1.06 1.77 rs375694 21 42907029 9.0X 10⁶ Additive 1.61 2.09 CR592664 rs1888533 21 45825267 1.0X 10^"5 Dominant 1.85 1.59 rs10483096 22 16926334 1.4X 10⁵ Recessive 1.21 1.94 PEX26 Applicants thus prioritized 59 SNPs showing significant association in Stage 1, including one of the 8 significant TCF7L2 markers, for rapid confirmation on a larger cohort.

Stage 2

I. Research subjects

The second stage cohort included 2,617 subjects with T2DM and 2,894 control subjects. Inclusion criteria for cases were (i) T2DM according to 1997 ADA criteria; (ii) BMI < 35 kg/m². Diabetic subjects were recruited at the UMR8090 CNRS unit in Lille (N=493), at the Endocrinology-Diabetology Department of the Corbeil-Essonnes Hospital (N= 1,339) and at the Endocrinology-Diabetology Department of the Poitiers University Hospital (N=790). Inclusion criteria for controls were (i) age at exam > 40 yr.; (ii) normal fasting glucose according to 1997 ADA criteria; (iii) BMI < 35 kg/m². They were ascertained as part of the D. E. S. LR. (N=l,676) (Balkau, 1996) and from the "Fleurbaix-Laventie Ville Sante" cohorts (N=226) (Lafay, Basdevant et al. 1997), or at the UMR8090 CNRS unit in Lille (N=998). The "Fleurbaix-Laventie Ville Sante" Study is a longitudinal epidemiological study on the determinants of weight gain. It included 294 families in 1999 (431 children and adolescents, 206 fathers and 244 mothers). All subjects were of European ancestry. The age restriction for the controls is chosen to re- duce their chance of developing diabetes later in life, thereby ensuring that they are true controls and not undiagnosed cases.

Unlike the Stage 1 sample, the affected individuals studied in Stage 2 were not required to have a family history of T2DM or to be lean. However, severely obese subjects were excluded by requiring BMI < 35 kg/m². The inclusion criteria for control sub- jects in Stage 2 differed from those for Stage 1 control subjects in that Stage 2 controls included individuals with normal fasting glucose according to 1997 ADA criteria (<6.1 mM). The Stage 2 cohort was chosen to be more representative of the diabetic patients than would be seen in the general population. This reduces the chances that a locus identified in Stage 1 would be predictive of a subphenotype of diabetes (for example, lean diabetic patients) and not of diabetes in general. This may result in a more conservative assessment of the T2DM association. II. Genotyping Methods

Sequenom iPLEX assays (Sequenom, Cambridge, MA) were used to obtain genotypes for 59 out of the 66 unique SNPs that passed the selected cutoff thresholds. Only the strongest associated SNP out of the eight SNPs located in TCF7L2 was tested. Locus-specific PCR primers and allele-specifϊc detection primers were designed using the MassARRAY Assay Design 3.0 software (Sequenom). The sample DNAs were amplified in a 25-31-plex PCR reaction and labelled using a locus-specific single base extension reaction. The resulting products were desalted and transferred to a 384-element SpectroCHIP array. Allele detection was performed using Matrix-Assisted Laser De- sorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS). The mass spectrograms were analyzed by the MassARRAY TYPER software (Sequenom).

III. Association Testing in the Second Population

Applicants successfully obtained genotypes from 2,617 T2DM cases and 2,894 controls for 58 SNPs. Four SNPs, rsl256526, rs5930, rs5984618 and rs7712842, were not genotyped using the iPLEX assay. Of these, rsl256526, rs5930, and rs7712842 were genotyped using fluorescence polarization assays, while rs5984618 was not. Applicants performed a joint analysis of first and second stage data by combining the allele counts obtained in each stage (Skol, 2006). SNPs were filtered according to call rate (>95% required), deviation from Hardy- Weinberg equilibrium (p>0.001 in controls required), and minor allele frequency (MAF>0.01 required). Of note, genotypes for rs932206 were not in Hardy- Weinberg Equilibrium for samples in the control population (pHWE = 6.5 x 10^"5) and this SNP was excluded from further analysis. The first stage and second stage genotyping data were analyzed jointly for association with T2DM. Test statistics for additive, dominant and recessive models were calculated according to published methods (Sasieni 1997) and the MAX statistic was formed across these to select the strongest obtainable association for any of the three models.

The joint analysis confirmed associations (P< 0.05) for 53 SNPs (Supplementary Table 1). A further 7 SNPs, located in TCF7L2, were not tested in Stage 2, but were validated in other studies (Supplementary Table 1). Twelve SNPs did not achieve significance in the joint analysis: of these, however, 4 (rs6541240 and rs35666, rs7651936 and rsl 1190578) were confirmed by other studies and showed association with T2DM at p<0.05 (Supplementary Table 1). This suggests that the remaining unconfirmed associations may be validated in additional studies with greater statistical power.

References for Stage 1 :

ADA (1997) Report of the Expert Committee on the Diagnosis and Classification of

Diabetes Mellitus. Diabetes Care 20(7): 1183-97.

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane

CR, Schaffner SF, BoIk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES (2000) The common PPARgamma Pro 12AIa polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80. Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J (2003) Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development. MoI Cell Biol 23:6713-24.

Balkau B (1996) An epidemiologic survey from a network of French Health Examination Centres, (DESIR): epidemiologic data on the insulin resistance syndrome. Rev Epidemiol Sante Publique 44(4): 373-5.

Bjork BF, Katzov H, Kehoe P, Fratiglioni L, Winblad B, Prince JA, Graff C (2006) Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. Neurobiol Aging. 2006 JuI 28; [Epub ahead of print] Boras K. Hamel PA. (2002) Alx4 binding to LEF-I regulates N-CAM promoter activity. J.Biol Chem 277; 1120-7.

Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS (2004) Hex homeobox gene- dependent tissue positioning is required for organogenesis of the ventral pancreas.

Development 131(4):797-806.

Bort R, Signore M, Tremblay K, Martinez Barbera JP, Zaret KS (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol 290, 44-56. Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, Rouault JP, Wrutniak-Cabello C, Cabello G (2005) Coactivation of nuclear receptors and myogenic factors induces the major BTGl influence on muscle differentiation. Oncogene 24:1698-710.

Campbell CD, Ogburn EL, Lunetta KL, Lyon HN, Freedman ML, Groop LC, Altshuler D, Ardlie KG, Hirschhorn JN (2005) Demonstrating stratification in a European

American population. Nat Genet 37:868-872.

Chimienti F, Devergnas S, Favier A, Seve M (2004) Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53:2330-7. Clayton DG, Walker NM, Smyth DJ, Pask R, Cooper JD, Maier LM, Smink LJ, Lam AC, Ovington NR, Stevens HE, Nutland S, Howson JMM, Faham M, Moorhead M, Jones HB, Falkowski M, Hardenbol P, Willis TD, Todd JA, (2005) Population structure, differential bias and genomic control in a large-scale, case-control association study. Nature Genet 37:1243-1246. Deeb, SS; Fajas, L; Nemoto, M; Pihlajamaki, J; Mykkanen, L; Kuusisto, J; Laakso, M; Fujimoto, W; Auwerx, J (1998) A prol2ala substitution in PPAR-gamma-2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genet 20: 284-287. Devlin B, Roeder, K (1999) Genomic control for association studies. Biometrics

55:997-1004. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P,

Stern MP (1999) Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 1Oq in Mexican Americans. Am J Hum Genet 64:1127—

1140.

Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 100:4162-7.

Fingerlin TE, Boehnke M, Abecasis GR (2004) Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information. Am J Hum Genet 74:432-443.

Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Bostrom K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L (2006) High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes 55:128-35.

Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, Langefeld CD, Ally DS, Mohlke KL, Silander K, Kohtamaki K, Chines P, Balow Jr J, Birznieks G, Chang J, Eldridge W, Erdos MR, Karanjawala ZE, Knapp JI, Kudelko K, Martin C, Morales- Mena A, Musick A, Musick T, Pfahl C, Porter R, Rayman JB (2000) The Finland- United States investigation of non-insulin-dependent diabetes mellitus genetics

(FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67: 1174-1185.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell

KATP channel subunits Kir6.2 (KCNJI l) and SURl (ABCC8) confirm that the

KCNJl 1 E23K variant is associated with type 2 diabetes. Diabetes 52:568-72

Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J,

Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A,

Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-3. Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glumer C, Borch-Johnsen K, Jorgensen

T, Hansen T, Pedersen O (2006) Studies of the relationship between the ENPPl

K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333

Danish white subjects. Diabetologia 49:2097-104.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly. S, Menzel S, Hattersley AT, McCarthy MI (2003) Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes 52:1300-1305. Gu HF, Efendic S, Nordman S, Ostenson CG, Brismar K, Brookes AJ, Prince JA (2004) Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. Diabetes 53:2137-42.

Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M,

Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P,

Kadowaki T (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes

51:536-40. Hart AW, Baeza N, Apelqvist A, Edlund H (2000) Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature. 2000 408(6814):864-8. Hinds DA, Kloek AP, Jen M, Chen X, Frazer KA (2006) Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet 38:82-5. Hong Y, Leppert MF, Lin J, Hunt SC, Rich SS, Arnett DK, Myers RH, Eckfeldt J, Williams RR, Province MA (2000) No evidence of linkage between the very-low- density lipoprotein receptor gene and fasting serum insulin or homeostasis model assessment insulin resistance index: the National Heart, Lung, and Blood Institute Family Heart Study. Metabolism 49:293-7.

Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi

I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ,

Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet

26:163-75. International HapMap Consortium (2005) A haplotype map of the human genome.

Nature 437:1299-320.

Jackson AE, Cassell PG, North BV, Vijayaraghavan S, Gelding SV, Ramachandran A,

Snehalatha C, Hitman GA (2004) Polymorphic variations in the neurogenic differentiation- 1, neurogenin-3, and hepatocyte nuclear factor- 1 alpha genes contribute to glucose intolerance in a South Indian population. Diabetes 53:2122-5.

Karamohamed S, Demissie S, Volcjak J, Liu C, Heard-Costa N, Liu J, Shoemaker CM,

Panhuysen CI, Meigs JB, Wilson P, Atwood LD, Cupples LA, Herbert A (2003)

Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Diabetes 52:1562-1567. Kayali AG Van Gunst K, Campbell IL, Stotland A, Kritzik M, Liu G, Flodstrom-

Tullberg M, Zhang YQ, Sarvetnick N (2003) The stromal cell-derived factor- lα/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. J Cell Biol 163:859-869.

Kohler K, Bickeboller H (2005) Case-control association tests correcting for population stratification. Ann Hum Genet 69:98-115.

Laukkanen O, Pihlajamaki J, Lindstrom J, Eriksson J, Valle TT, Hamalainen H, Ilanne-

Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M (2004)

Polymorphisms of the SURl (ABCC8) and Kir6.2 (KCNJI l) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. J Clin Endocrinol Metab 89:6286-90.

Lee H, Cha S, Lee MS, Cho GJ, Choi WS, Suk K (2003) Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia. J Immunol 171 :5802-11. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genet 33: 177-182.

Love-Gregory LD, Wasson J, Ma J, Jin CH, Glaser B, Suarez BK, Permutt MA (2004) A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 2Oq is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140.

Marchenko GN, Marchenko ND, Leng J, Strongin AY (2002) Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. Biochem J. 363:253-62.

Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y (2003) Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation. Am J Hum Genet 73:233-46.

Meigs JB, Panhuysen CIM, Myers RH, Wilson PWF, Cupples LA (2002) A genome- wide scan for loci linked to plasma levels of glucose and HbAIc in a community- based sample of Caucasian pedigrees: the Framingham Offspring Study. Diabetes 51 :833-840.

Merat S, Casanada F, Sutphin M, Palinski W, Reaven PD (1999) Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet. Arterioscler Thromb Vase Biol 19: 1223-30.

Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clement K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P (2005) Variants of ENPPl are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat

Genet 37:863-7.

Permutt MA, Wasson J, Cox N (2005) Genetic epidemiology of diabetes. J Clin Invest 115:1431-9.

Pritchard JK, Stephens M, Donnelly PJ (2000) Inference of population structure using multilocus genotype data. Genetics 155:945-959.

Rampoldi L, Dobson-Stone C, Rubio JP, Danek A, Chalmers RM, Wood NW, Verellen

C, Ferrer X, Malandrini A, Fabrizi GM, Brown R, Vance J, Pericak- Vance M,

Rudolf G, Carre S, Alonso E, Manfredi M, Nemeth AH, Monaco AP (2001) A conserved sorting-associated protein is mutant in chorea-acanthocytosis. Nat Genet 28:119-120.

Reich DE, Goldstein DB (2001) Detecting association in a case-control study while correcting for population stratification. Gen Epidemiology 20: 4-16.

Renshaw D, Batterham RL (2005) Peptide YY: a potential therapy for obesity. Curr

Drug Targets 6:171-9. Saeki K, Miura Y, Aki D, Kurosaki T, Yoshimura A (2003) The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction. EMBO J 22:3015-26.

Salonen JT, Fuentes R, Kontkanen O, Pirskanen M, Uimari P, Aalto J-M (2006) Method for detecting the risk of and for treatment of type 2 diabetes. WO/2006/008342. Sasieni PD (1997) From genotypes to genes: Doubling the sample size. Biometrics

53:1253-1261.

Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G, Chines PS, Erdos MR, Narisu N, Conneely KN, Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J, Watanabe RM,

Boehnke M, Collins FS (2004) Genetic variation near the hepatocyte nuclear factor- 4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes 53:1141-1149. Skol AD, Scott LJ, Abecasis GR, Boehnke M (2006) Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38:209-13.

Takanaga H, Mackenzie B, Suzuki Y, Hediger MA (2005) Identification of mammalian proline transporter SITl (SLC6A20) with characteristics of classical system imino. J Biol Chem 280:8974-84.

Traiffort E, Ruat M, O'Regan S, Meunier FM (2005)Molecular characterization of the family of choline transporter-like proteins and their splice variants. J Neurochem

92:1116-25.

Tsuchiya T, Schwarz PE, Bosque-Plata LD, Geoffrey Hayes M, Dina C, Froguel P,

Wayne Towers G, Fischer S, Temelkova-Kurktschiev T, Rietzsch H, Graessler J,

Vcelak J, Palyzova D, Selisko T, Bendlova B, Schulze J, Julius U, Hanefeld M, Weedon MN, Evans JC, Frayling TM, Hattersley AT, Orho-Melander M, Groop L,

Malecki MT, Hansen T, Pedersen O, Fingerlin TE, Boehnke M, Hanis CL, Cox NJ,

Bell GI (2006) Association of the calpain-10 gene with type 2 diabetes in

Europeans: Results of pooled and meta-analyses. MoI Genet Metab 89:174-84.

Ueno S, Maruki Y, Nakamura M, Tomemori Y, Kamae K, Tanabe H, Yamashita Y, Matsuda S, Kaneko S, Sano A (2001) The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis. Nat Genet 28: 121-122. van den Hoek AM, Heijboer AC, Corssmit EP, Voshol PJ, Romijn JA, Havekes LM, Pijl H (2004) PYY3-36 reinforces insulin action on glucose disposal in mice fed a high-fat diet. Diabetes 53:1949-52. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprtre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APMl gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Molec Genet 11 :2607-2614.

Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S,

Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ,

Jones E, Prestwich P, Simecek N, Rao PV, Wishart M, Foxon R, Howell S, Smedley

D, Cardon LR, Menzel S, McCarthy MI (2001) A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (The Diabetes UK Warren 2

Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome Iq. Am J Hum Genet 69:553-569.

Winckler W, Graham RR, de Bakker PI, Sun M, Almgren P, Tuomi T, Gaudet D,

Hudson TJ, Ardlie KG, Daly MJ, Hirschhorn JN, Groop L, Altshuler D (2005) Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people. Diabetes 54:886-92. References for Stage 2:

Balkau B (1996) An epidemiologic survey from a network of French Health

Examination Centres, (DESIR): epidemiologic data on the insulin resistance syndrome. Rev Epide-miol Sante Publique 44(4): 373-5. Lafay L, Basdevant A, Charles MA, Vray M, Balkau B, Borys JM, Eschwege E, Romon

M (1997) "Determinants and nature of dietary underreporting in a free-living population: the Fleurbaix Laventie Ville Sante (FLVS) Study." Int J Obes Relat

Metab Disord 21(7): 567-73.

Sasieni PD (1997) From genotypes to genes: Doubling the sample size. Biometrics 53:1253-1261.

Skol AD, Scott LJ, Abecasis GR, Boehnke M (2006) Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat

Genet 38:209-13.

The foregoing written specification is considered to be sufficient to enable one skilled in the art to practice the invention. The present invention is not to be limited in scope by examples provided, since the examples are intended as a single illustration of one aspect of the invention and other functionally equivalent embodiments are within the scope of the invention. Various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and fall within the scope of the appended claims. The advantages and objects of the invention are not necessarily encompassed by each embodiment of the invention.

HHEX/IDE are used interchangeably herein. CXCR4 and DARS are used interchangeably.

Supplementary Table 1

TTGAATTTCACATAAI I I I I I I I I I I I I I IGAG

ATGAAGACTCACACTGTCGCCTGGGCTGAT

GTGCGGTGGGGCAATCTCGGCTCGCTGCA JI

GCCTCCATCTCCTGGGTTCAAGTGATTCTT *

CTGCCTCAGCCTCCCGAGTGGCTGGGACT

ACAGGCGCATGCCACCACACCGGGCTAAT

TTTTGTAI I I I IAGTAGAGACGAAGTTTCAC

TATGTTGGCCAGGTTGGTCTCGAACTCCTG

ACCTCGTGATCTGCCCACCTCGGCCTCCC

AAAGTGCTGGGATTACAGGTGTGAGCCAC

CGTGCCTGGCCGAATTTCACATAATΠTTAT

ATGTCATAAAATATTATTAI 1 1 I IAI I I I I I 1 1

TGTCGATGATTCAAAAATATAAAAACTATTCT

TAGTTCACAGGCTATACAAAAACAGCCTGG

ATTTGGCCCACTTTGCCTGGACCATAATAAT

GTCTATTGGGAGATAGCCAAGAATTGCTTT

TCATCGATGTGTGTGCTTTATGCTTCTATGA

CTACCTGGACAGTTTCCAGAACACTTTCAA

GCCTTACTAGGAATGATTTGTAATG

Supplementary Table 1

CHr Position 5' Flanfclng Sequence SNP Base 3' Flanmnq Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value

1 95036805 GTACAGA6ACTTGCCCCCAGCCTCAGCTG A/C TTTGATTTTGTTATTCTAAGATAACACAAAAT A Both 1 SE-06 268E-01 SLC44A3 lntron

TACCTGATACCCCAAGTCCAGGCCCTCTCT

GCTTTCCCTCTCTGGAGMCAAATTTTCCTG

TCTTCAGCTGGTGTGGAATTTGGGGGTCTA

ACTACTCCTGAGGAAGGCTTTCAGCTAATC

TTTGGAAATACI 1 1 I

GCCTCTCTGGGATTCTGTGGCTCACTTCAG

GCTGCATCTTATTTGTCCTCCTCATGCAGC

CAACACACACGGACAGGCTGCTTCTGCTTT

CTCCAGCGGGCTTAGGGCACTGCTCCACC

TCCCTCTC 1 1 I 1 1 GGCTCTCACCATTTGGTT CAAGGTCA GGTGTTTCTTATCTGCTGTCATTGCCTCTCT GTTTCTTACTGTCCTGGTGTGTTTGTGCCT GTTTCAATCTTTCATGAI I 1 1 I IGAGTGGCT GGAGAAAGGGAAGAGATTAGGAGATAAAT GCATATGCTTCACTGGAAGTCCAAATTAGAA GTCCTCATTGAAAATG

1 120882655 AAACACTAGATGTGTATTTGGAAAAACCTAA CVT TTTGGAGTTCCTTGGTTGCTTCTCCTTAGCA T Hap300 1 5E-O5 939E-03 LOC642123 Flank

CTATTGATTTAATAATAGTTTGTGATGTTTTA ji

AAACAGATTAATGACTCTTAGGAATTTAAAA 'J

GACTAAGATTACTTTGGAAACATGGAATCCA

AAACTGTGAAAGAAAAAGCAGAGAAAGCAG

GGCTGGGTTTAA

1 196863741 AGAAAGCCAGACAGATTGAGCTACATTTTA CfT T Hap300 85E-05 1 S9ε-O3 NR5A2 lntron

GACACTGAGTTTGAGATGTCCCCTGGCTAT

CAGGTAGAGACATCTAGTAAATAGTAAACA

GTCATATGTA CACATGGAA

1 227397313 AAATATCTGCCTACAAGAGATACTGATCTTT A/G A Humani 25E-05 597E-02 TTC13 lntron d

TTCTAAGGCCATCATTCATTTTCAAATCCCA AGAACAAAAACAGGGACTCAAATGTATTAAC

AATAATCTTTGTGATGTCTCCTAGCTATCAC

AAAAGCTAGTAATAAGCCTAAATAATGTCCA 1 1 1 1 1 CCTACTTCT

CATAACATGGCAATGTGAI I I I I IACTGTGA

ATGTTATGAGAAATACCCAAATAGCATCACA

AATCTCAATTCCTG

1 233862625 TCTGGGAAGTCTGATTATTGCAAAGTTGTTA GfT CTTTGTAGTTAAGAGTCAGAATCAGAATCTG T Humani 98E-06 2 13E-01 RYR2 lntron ccTTTTTAAAAAATAAAGGCAGATGTTAAGC

ACAATTTATATTTAAAGTCTATAAACATAGGG

GATTATCGTGGGCTACCTGTCTTGAGGTCA

GACTGACATTTCTGCTGTGGCTAAAAACAA

GTTTAGGGACCCTGGGAGCCTCTTGGCTA

TAACCTTGGGAGCCATT ATTAI I I 1 1 CCAGTGA

Supplementary Table 1

AAAGCAGCCTCTGTTTAAGGGAGGTCCACT CCAATGTAGACTGATTCTΠTGCTTCCCTCC ACGGGCTAACTCCCTGAGACCCTCCTCCAT

Supplementary Table 1

ccACCAGTCACACAACTGTTCTCATCTCTcc

Supplementary Table 1

Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value

3 163505661 GrrASQTTTTTTCTβCCAGGQTTATTQGGT A/C TCATATACACATGCCCCATTTTGTAACATAG A Both 1 6E-05 8 16E-02 lntergenre C

TATTGAGGCATAATTGGAAAATAATGATTGT

ATATACTTAAGGTATTACAACATGATGTTTTG GTTTCATATCCCAAGTGATACTTGGATGACT

GTGTACATCTATATATTACACATATATATGTG

TGTATATATATGTGTGTGTGTGTATATATGT

GTGTGTGTATATATATGTGTGTGTATTACCA

TAATTAACGTAATTAACATCCATTGCAAGAAT AI I I I

TCTTGACACAGGGGATCAAAGCAGACCCA CTACAAGCAGGATGAGGTAGAGAQCTGGG

GCTACCACAGTATTTATACCTCTACAACTTG

CATTCTTAGGTCTAGTTTGGTAAGAAAGAAC

ACTCACTCCAGTCTAGCAAAGCAACTTTATT TAAAAGTCAGTGTATrTTTTCATGCACACTAA

ATTCACAACAATCAACGGAAGTCTGGAATC CTTTCCTCAGTCTGGAGGCAGAAGTTTGTC

CATGGCAAGCCAATTTCCCAAGGCTTAGAA

GAGCTGCCCAAGATGGCTGGAGT

AGATGTATTTCACTAGGCCCATGAATATCAC

TGCCATAAACAGGATGCTCAGGCCTGCCTG

AAACAGTGAATAGCTCAGGATTCCAGTGATT

CAGGTAGAAAGTGGCTAAACAGATAAATTG

CTGAATGAATTAGAAAACAGACAAATAAATG

TAATCCAAGTTTATGCTGCCTAGAAGAGTAC

ATCAGGCTTACTAGAGACCTACCAAGCCAA

GTATAGTTCATTTATGTCTTTTATGAGATCTT

TGGTATTATACATAGGAGTCAGTGATAAGTG

ATAAAAAAGCGATAAGAAATCTGTCCCTGTC *

CATGACAGGTATTACTTCCTCCACTGCCACT

GCTTTGTCAGCTCAGCAGACATCCCTCAAC

TCCATCAGGAAGAGTATTTTAAAGAACATAA

TTGTTCTAGACTTTAATTGCTAGACAGAATT

GCTCCATCCAACTGGGAGGAGTGTGTGTA

GTTGTCAGTACCTCCTGCTGGATCAATGTC

TCAAGAATTATAGACAAGTCAAA

166780254 AAGTTATTTGATCATAAACAAACAACACATrT C/T GTTCCAATTTATGTTAAATGATGTCCTCCAG T Hap3∞ 49E-O6 1 89E-02 lntergemc

GATTTAAAATGAAAATCTGACATCCAATTTG TGTCTCCTGTGGAGAAGTTGCTTTGCTGAT

CAACCTTCTGTGAGCTAATACATTACCAGAT

AAATCAATTCTATCATTGAATTGAATAGCAAT

TATAAGAATGTGGTTAAGTCAGCCAATTCAG

TTGTATTTGGTGAAGCAATΓTATGGTATTGC ATAGCI I I I IATAATTATTTGACAACCTAGTT

CCATAAATGTGA

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-valuc

59343615 CTGTGAGTCTGGCAQTCATTCAAAACTTGC C/T ACGGTGGCTGAGTTTGGTGCTATTGAGTTG Both 2.8E-06 1 C5E-03 lntergenic

CAACAGCAAAGGAGAACCAAGTGGCTTTTA

TAATGTATTTTTAAGTGAAAGTCATAAAAAAA

ACTCCATTTCATTAAGTGCTTAAAAAGAGCT

TCTTGAAAACATATTCAGTTCGAGAAGCCCA

GCTCCCAAGTGAGTCCTGTCACTCCACAGT

AAGTGAGTTTATTTTC

81567021 TTTATACTTTAAAGTATTTCTGGGTTAAATGA AACTAGTAAACATATGTTCCTAATAAGTGAA 6 3E-06 1 72E-06 FGF5 AACAATGAAATTTTTTAGTATGTTCAACTCTC GGGAAAGATAATAATGATGGTCAACAATAAG ATCCAAATGGCATATGACCCTGTTTACACAG CCACGTCAATGCATAAGTTGTATAGGCTAAA CCTAAAGCTAAAAATATTACTCTAGTTTATTC TGTTGCTTGTAGGCTACATTAAACTCAAATG TAATCTATTGTTAAGTATTGTGCACTGTATA TAATAGTTTATCTTATACTCCTGGTTTGATTT CCAAGTTCTTAGGGCACATGAAAAATTTTAG GATTAGCATATTAACGTGAAAGTAGGATAGC CTGCCAAACAG TACTAAATATATA

99861413 TGGGTCAGGACCATGAAGTTAATTTTCTTC cπ GAAGTTGGGTTGAGGGGATGAGGGTAGGA Hap300 36E-06 1 64E-03 TSPAN5 CTCCTTTTAATCATCAAAATGGAATrTCTGTT GGTGAGTGATGTATGGATAAATACAACGTT TTGCCTGTTAGAGATTATTGATATAAGAAAG CTATTTTCTAATGGTAAGTATATCTGCCTTC GCTGGGCGTTAAATGCTGAGAACACATGG CCTCCCTCCAGTGCTTTTATACGGTACCAA ACACATAGAGGGGAACAATCACACCCTGG GGAATATGTTTTGCI I 1 1 GGCCTGGTGGAGGGTGGAGGGTGGGAG GAATTCACAACTCATAACAGCTATTTGACAT GAGGGAGGGGATTAAGAAACAACGAATGG CTTTTGTGGGTACCAAGCTCACTTTTCTTCT GTACTAGGCTGAATACCTGAGTGATTAAAC TTCCAGTGATAAGTGCCTTAATAGAACAAAG AGTCTGTACAACAGACCTCCATGACACAAG TCAACATAATCCTTGCCTCCAGGGAGCTTG TTTACCTGTGTAACAAACCTGCATTTTAAAA CAGTTTAATGAGGGGGGCACATGTTTACAA GTTAAAAAAATGAAAGGCTTTATATCAATAAA TATAGTGGGGTCAGTGCTGGGGAGGCATT TAAGTGGGCCTAAAAAAGGGAGACAAAATG GAGGAAGAACTTAGTGTATGAATCCATCTC AAGGAAAATTATTCTGGATTCTTAAGAATAA CGAACTTCAGTGATGTGGAAAATAAGCTGT AAGTGAAAATATCGGACTAAACTGATAAAAT TAGAAAGATATCTTGGACTTCAI I I I ICAAG GAGGTAGAAAATAGAGGAATCACATACACA CAGCTTGAACTCCTCAAACAATTGTTCTGCA GTTTTGACTTCCAACCCACTTTGCCTTAAGT GACTTATTTGCCACGAGATTTGTGACTTGAA TATTTCAGTTGACAAGT GTCTAGTGTTTAGA

Supplementary Table 1

TAAATCCTCTMTGCTTAAGCCATTTTTAGT TGGGTGTCTGTACTTTGCAACAGCAATAATT CTTATACACTAATGTATAAAACAGATTAAAAT TGACAAATTATTATTAAATATRTATTTTATAGG CTTTAATTTGTAACTTTTATTATAAGAAGATA ATGAAGAATTGCTGAGACACAAAACTTAAAA TGGAGAGTTATGGATATAAATTGAAGTCATA TCAGTCTTAGCATCCAATTTATΠTAGCATΓT TGTTTTGAGTGTGTAATAGTGAGGGAAGTC

Supplementary Table 1

Supplementary Table 1

SNP Chr Position 5' Flanking sequence SNP Base 3' Flanking sequence Risk Chip stage 1 P- Joint Stage 1 Gene Location Reference

... . .. . . . .

8944645 TTCATACCTGTCAAACATATTATAAAATGGC A/G G Hap300 27E-06 522E-04 Mergence d

AAACAAGAATTAAATAACTTTTGGATTATTCT ATACATTAATGGCAGACTACTGG 1 1 1 1 I I IC

GCACAGTTGATCATTTCTGGGTAAGAAAAAA

AATTGGCAAAACTTTATTTGTGAAGCAACCT

AAATGCCTAGTGATAGAATATGATTAAAGTT AAACGAGTCAGGCACTGATAAAGTAATAGG

TTAAAAATTGGCCAGGTGCGGTGGCTCAC

GCCTGTAATCCCAGCACTTTGGGAAGCCG

AGGTGGGCGGATCACGAGGTCAGGAGATc

AACACCATCCCGGCTAACACGGCGAAACC

CCATCTCTACTAAAAAAATACAAAAAAAATCA I I I I IC

GCCGGGCGTGGTGGAGGATGCCCGTAGT

CCCAGCTGCTCGGGAGGCTGGGGCAGGA

GAATGGCGTGAACCCGGGAGGCGGAGCT

TGCAGTGAGGCGAGATCGCGCCACCGCAC

TCCAGCCCGGGCGACAGAGCGAGACTCC TTrTGGCTAAGGCATATGAGCAACCTATAAT

GTCTCAAAAAAAAAAAAAAAAAAGTTTTAAAA ATGTTCAGAGTCCATAGGCCTG

7969769 ACCTTCTCAAGTGAGGATATTTGAATATAAT A/T T Human 1 1 5E-04 296E-02 ICA1 lntron

AATTAAAAGTAACTGAGTTTATGGGACTTGT

ACAATCTCCCCTTTAGCAATGTCAAACAAGT y

ATTTTAAAGGAGCAGGACCAATCATTAGACT CAGTTCTCTCTTCAGCATTCTGAGTCCTGG K

CAAGTTCACCACAATTCATCTCCCAGGAACA AATAATGATGCTTTCTGCAATGGACTrTGCT

TGTATCTCAAGGTTCAAGGTTCAATTCGCG

CTTTTGGATTGCAGT

TTTAAAGTAGTAAATTCATATGGTTGATAA

20248324 ACTCTCACTGAGTTTGCCTGTGGTCCTGTT G/T TTCCCTACCTGCACGAGGGATGGTGGAAG G Hap300 26E-O5 880E-02 lnteigentc

ATTCTTGCATccAGTTCATTTCATGCCTTGc

CATTGGCTTGGCCTTAACTAATAGCGATGG

CCTGTGTCTTCATGCTGTCTTAGTGCACAG

CCGCACCTGCACCAAGCTGTACTGCAGAC

ATAGCTGTAAGCTTCTGTTCTTCTCTTTAAG

AATATCCCTGAGAGTCTCG

118253964 TGCTGCACTAGAGTTTCCCCTGCCTTGTCT CfT GGGACAGCCAAGTGGTTCGGAGAGAAATT C Hap30D 72E-06 1 98E-11 SLC30A8 Nonsynonymous e g h

GTGTGAATGTAGCTGATTATCAGAGCAAAC

GTGGCTTCCTCTGAGTGCCCTGCCTCTGC

CCCACCCCAGCAGGTCAAAGACAAAGTACT GTrGACCAGGACCCCGACTGCCTTTTCTGT

TGAAGTTGGAGTCAGAGCAGTCGCCCATG

CGTGTGCAATCAGTGCTAATCTCCCTGTGC

TTCTTTATCAACAGCAGCCAGC

Supplementary Table 1

Humani

TGCTTAAGGATAi I I I ICTTATTTTATTAAAAT TTGGGCTTAAACAAAGGAAAAGAGGTΠTG

AATTTCTGTΠTGAGGCATAI I I I ICTCAAAG GGCTTCAGGGATAGGGGTTGCTGGGGAG

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value rs10823406 10 709S2029 GCGATATGAGCCCAGGTCTCTGGGAATCTA A/G TGTGGGAAACACAAGCAGAATCAGAAGTTC G Hap300 1 1E-05 609E-06 lntergenic b d

GGCCAGTGTGATΓTCTGCTATATTCTGTGG CCCTGGCCTCTCCCTGGGTCCTCTTTTTCC

Supplementary Table 1

Supplementary Table 1

Chr Position 5' FlanMnq Sequence SNP Base 3' Flanking Sequence RIsK Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value

10 102228943 AAACAAGTTGGTGTCTCTGCATTATATTCTG OT ATTACAGATAGAAAGATTGAGACCCAGAGG C Hap300 69E-05 324E-01 WNT8B Iπtron d

I 1 1 1 IGI I I 1 1 1 I 1 1 ICCCTTATAGGTCGGTG

AACAATTTCCTGATGACTGGTCCAAAGGTAA

GAACAAATTCCATTAATTGATATGGATTTCA

CTAATCTTAGCCTGTTGACTAAAGATGATAA

ATGCAGAI 1 1 I I CATTATATCCACATATTTTA GTCAGGCTGCAAAGTCACACATCCTTCTCA

TTATGCTGTATA

GTTTAAAATGCTGGAATTGTACTACATGATC

TTTACATTCATGGGCATTTTCAGTTCCAAAAT

GTTGTTTTCTAAGATGGTCATGTGATGAGAA

CTCCTTAAATTTCATGAATTAGGTGATTTGG

GCTCATTTT

10 114748339 TTTTGGATCTGTTTCTTTAATTGTAAATTGAA OT T Hap300 39E-19 < 1 OE-30 TCF7L2 lntron b c d e f g h l

TCGGACTAAAACCTTTCCAATTTTTTCACAT

GTGAAGACATACACAAAAGTTTTATTGGAG

GGTTGCACATGTGAAAGAAAAAGGGAGAAA

GCAGGATTGAGCAGGGGGAGCCGTCAGAT

GGTAATGCAGATGTGATGAGATCTCTGCCG

GACCAAAGAGAAGATTCC 1 1 1 I IAAATGGTG TAAACATTTTAGC I 1 1 1 I GTGTTTGCTGACT

ACAAATTCATGGGCTTTCTCTGCCTCAAAAC GGCAACAATACATAGTGAAAGTTCTAATAAT

CTAGCACAGCTGTTATTTACTGAACAATTAG I I I IC

AGAGCTAAGCACTTTTTAGATA ^J

GATCAGCAGTGTGAGAGGTTAI I 1 1 ICCAT

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' FlanKinq Sequence RIsK Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value — rs79M519 10 114763917 ATCAGTAAGTGCTGACTGACTGAGGCGCC A/G G Hap300 22E-11 n a TCF7L2 lntron b e d e l

CCACACATCCGGCTTCCTTCTGTTACTCTAC

GCGTGTTGCTGAAACTTAACGAACCCATGT

GGGGTCTTCTCGCCTGGTGCAGTCCGGCC

CAGTATTCATACTGAGGTTTGCAGTGGGAG

AAAGGAAGGTATTTATTTGTAGGTCACCAA

GCAGGGCAAATCCAGCAGCTCACGCTTAA

GACCTGACCTCTCCCATGGTTTATAAGCAA GTGG I I I 1 1 I I I 1 1 1 1 1 1 1 I I 1 1 1 1 1 CAGACT GAGTCTTGCTCTGTCACCCAGGCTGGAGT GCAGTGGCGTGATCTCAGCTCACTGCAAC CTCCGCCTCCCAGGTTCAAGCGATTCTCCT GCCTCAGCCTCCTGAATAGCTGGGACTACA GGCGTGCGCCCCCACACCTGGCTAAGTTT TGTCTTTTTAGTAGAGATGGGGTTTCACCAT GTTGCCCAGGCTAGTTTCCAGCTCCTGACC TCAAGTGATCCTCCTGCCTTGACCTCCCAG AGTGCTGGGATTACGGGCATGAGCCACAG TGCCTGGCCTGTAAGCAAGTGI I I I IAAAG AAAGGGGTAAATTTTAGGGAAACAGAAGTT CTAGGCAAAATGGTAAATTAATACAGGGAG GTAAGACATTGGTTTGGCCTAAAAAGATGG GATATTTTGAAGTGGGGGCTCATAGGTCAT

AAGTGGATTTAAAGAI 1 1 I 1 1 ^ TTGGGGTCAGCAGAAAGAAATGTTAGGTCT GGCTCGTGGGCATGTCI 1 1 I ICTAGGCCC CTCCTTGGAAAGAACTTTAGAGCAAAGAAA GGCAGTTGGAGCTTAGTCCCCACTTTCTCC TGATCTGAGGTCTACGGACCACTGGATCCA TTTGGTGGGGTCCATCTTTCTGAAAAACAA GTCAGGGACATG

114783813 TGAAGGGACTTGTGAAATAGTTTCACAGAG AT A Humani 50E-09 n a TCF7L2 lntron a b cd i

TTTCAGTGTTAGGTATATTTGATCAATGCTA

ACTTTTGGAAAACTTTGGTGCCTGTATGATT

CAGAGGGTAGGGCAGAATATTAAATTAATC

ACAACTTCTTGTATTTTAACCATTCTGGGTA AAGAAATAAGTGTCCGCTATTGGGTTGTATA

AATTGGGATTCCGTGACGCCCAGGCAAAAT

TATTTGTTTATAGAAGA

Supplementary Table 1

GTTG 1 1 1 11

Supplementary Table 1

LOC387761 lntron

Supplementary Table 1

SNP Chr Position 6' Flanking Sequence NP Base 3' Flanking Sequence Rtek. Stage 1 P- Joint Stage 1 Location Reference Allele Value a 2 p-value

44212190 TTTTAGAATTGCCTCAI I I I C/T AAAGGGAACTGCTAI I I I 7 2E-06 3 61E-06 AAAAGCACACACTTTGGTAGAAAATGACCAT TTCTGTCTCACTTGACAGTATΠTAATTACCT ATTGAACATGCTTGGTCACTTGACCAAAAG GTATACCTACAAAATGCCTGGGGATATCAA CATTCTMTGCCTCCTTTTACCCTTCCTATTA GAACTGGGTAGATGCTCATATGAACTGTGA ATACAGCCTTGTGATTAATCTTATGAGAGAA AGATATTGCCATGAACTTCCTGGTGGCCAA AGCTTGTCCCCATGCCTTGGCTATGCTGCC CGTCACQGGAAAAGCAGTTATCAAGGTAGG CCTTATTTATCAGC AGGCTCTGCCACTCACTTGCTTTGTGATCTT

GGGCAAATATCTATTATCTGAGCCTAGGAA

GTTCTTGTAACTATAAATTAAATATAGGACTA

GATAAACTTTAAGCTCTATTTTAGTTTAAGGT

TCTATGATTGATGCGGTCACATT

44214378 AAAGCCCCATAAACAGGCCTAAGGCAGGAA AGGACAATAAAATCATGCTTGTGACACCACA 72E-06 ATAGAGATCAGAGGCTAAGGCGCACTTTTG CTGCATTCTTTTGTGTTGTAAGCTGAGATGT GTTGGAGGCTCACTTACCTCTCCACCATGT TGCATGCGCGTGCACACACACACACACACA GTGTTTGGTCTAGTGAAAGCCCATCTATGG CCTCGCCATTCCTCCATTCAACTCTGTCTG CTGTGCACTCAGGACACTTGAATΓTCTTTC GCTCAGCCAACGGCAGAACTCACAAGGGC GTGGGGTTACCTGCCAGAGGAGGACAAAA CCAATAAAAAAGGCTTGGAGGGCTTTTGCC ACATACCTGGCTGTCAGTGTC TTCTGTAACTGGAAAGAAG

O

Supplementary Table 1

Supplementary Table 1

T

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value S 2 p-value re1256617 14 64805437 TGAAGCAAGAATTGCAGACCCCAAACTTCC C/T TACGGTGGGCAGACAAAACTGATTTTCTGG C Both 25E-05 304E-05 IntergenK

TGTTTTCATCGTGTAGAAAGCTCTACTGCAA

ATATGGTCAATGTGCCTAAAACCAGAAGAG

CTTTCTGTAAGAAGTGTGGCAAGCATCAGC

CTTACAAAGTGCCCCAGTATAAGGGCAAGG ATGCAAACI 1 1 1 1 1 1 I 1 1 I I I

ATTCCTCCTATGCCCAGGGGAAGATGCGCT

GTGATCAGAAGCAGAGTGG

σ\

Supplementary Table 1

Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Stage 1 P- Joint Stage 1

Allele Value S 2 p-value

64809658 ATGGGCATTATTAGCTGAGGAGCTAATGCT G/T TTTGTATGTCTTATATACTTATATACAATAAA G Hap3O0 34E-06 304E-06 lntergenic

GCAACTCTTAATGTTCATAACCTGTTCCATA

TCATGATACACATAGGAAACGGAAAAAAACA

TTTATGTGCACACACACACACACACACACAC

ACACATATCACACTATGGAAAAAGTATGAGG

CTGCTGGCACCAGAGGTAATTAACCCAGAG

GTTCTAGCTGCCCTAGGCCTTGCATTGAGA

GGATCAATATCTTATCATACCTGTAACCCAC

TCCCTGGCCACCAGTTAGGAAGTTCTGGCT

TGGAGAAGTGTGCTAATTAGTTCAAGGCCA

CAAGGTTAATATATTAGTAGTTGATCCTTGA

ATAACACAGGGACAAGGGCACCAACTCCTG

TGCAGTAAGAACTTCACATGTAACTTTTAAC

TCCCCCAAAACTTAACTACTAATGGCCTACT

GTTGACTGGAAACCTTACCAATATTATAAAC

AACCAACTAACACATA

TAGCCTGGGTGACAGAATGAGACTCTATCT

CAAAAAAAAGAAAAAAATTAAAAAAATAAATA

AATAATTAGCTGGGTGTGGTGTTGTGCACC

TATAGTTCCAGCTACTCCAGAGGCTGAGAC

AGAAGGATCACTTGAGCCCAGGAGTTCAAG

GCTGCAGTGAGCTATGATTGTGTCACTGCA

CTCCAGCCTGCATGACAGAGCAAGACTCTG

TCAAGAAAGAAAGGAAGGAGGGAAGGAAG 2

GAAAAAGCGAAGGAAGGAAGGAAGGAAAAT

GAGGGAAGGAAGGAAGGAAAAGGAAGGAA

GAAGGGAAGGAAGGAGAAAGAGAAAATATA

TTTATATTCATTACATGGAAGTGGATCATCA

CTTCCACTTCATCCTTATTATGTTCATGTTAA

GTAGGCAGACTGAGAAGGAGGAGGAGGAA

GAGGAGGGTΓTGGTCTTCTTGTCTCTGGG

GTGGCAGA

Supplementary Table 1

Allele Value a 2 p-value

GGGGAAAATGAATCTΠTCATG GCACAGCAAGGAAGTGGCAGGGAGCACAG

GGATTTGGATGCTGGCCCAGCCCTTGGCA AAGCACTTTGCCCATCATAGGTGCTAAGCA CTATTTGAAAGTTAAATCCCTTCCTCACTAG GAGGAGCTGGAGGTAGGACTTTCAGTTTAA GAATAGCAATTACAGCTCACAACCATTAGGA TAGCTACTGTATAAAAACAAAACAGAAAATA GCAAGTGTTCGTGAGGATGTGAAGAAACTG GAACCCTTGTGCATTGTTGGTGAGAATGTA AAATCAGCTGCTGTGGAAAACATAGAATTAG CATATGACCCAG

Supplementary Table 1

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value rs1005316 17 66501964 AGGTrTCTTGTGAAATGTCGGCATTAATGAA A/G G Hap3M 96E-06 205E-04 lntergenic

ATTTTAATCAGTTTQTTTATCTAAGGAAQAAT

TATTTGCATATCATATTGCAGAAAATATAGTA

CTATAGTAAAGTTACCTGACTTTAGACTATT TTCTCATCTCCACACCTCCTQAAATGTCATT

ATTTAAGTGAATCACTTGTATCTTAATTTTCT

TAGACAATTTATAGTCTTTGGTTTTTATCAG

GGTGTTATAGTTAGCTGGATGTCCCTGTGA AGTTCCACAGATCAGTGGTGAAGCCATCCA TTTACCAATTGACTΠTAACCTTCTCTAGCTG ACAAAATGTGATTTATTTTCGTGCAAAGAAA ATGAGCTAAATGTTTGACTATAGCCAGGTTT TRTCTTGTAGCCTGAGTATATTGCACCTGAA AATCAGCTATTTCCTCAAAATATAACATAGAT CAAGGTTAGTGTTTTCCATGAAAGAAACCAT AGGACATTAATGGTTACAGGTGGAATATGT AL I 11 IATTGCACTTTATGTTGGTAATTTCCA AATCAGTTTCCATCTTGGAATAATTGTTTTAT ATGCACATTATAACCTACAACAGTACTAAGA TTTTCTTCACTACCAAAATTTATTGTCTTCCG GAGCTTATCCTGAAGCTTAGTATAAGTAGCA TTCAAATAGAAATGAGATAGAGTAAAAGAGA TTTGCTTCGTGAGAACGGAAGTCTATATATG

GGATTAAAAGTTATATAAATTATTATTTGAGC _

AAGGATTTATTGAAACCTCCAAACTCACTTA O

CCATTGTACCAATATTGTTTTATTAAGAATCC AAGATTGTACAATGTTAGCATATTTGAATGC

TTAAT

Supplementary Table 1

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3¹ Flanking Sequence RIs- Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value S 2 p-value rs6413504 19 11102915 GAGGGCCAGGAGGGAGGAAGGGAGAGGA A/G TGCTGGACTGATAGTTrCCGCTGTTTACCAT A Humani 2 7E-05 9 14E-O6 LDLR lntran

GGTGTTTTAI I I I 1 1 IGCI I 11 Al 1 1 I I IATTT

TGAGACAGAGTCTCTCTCTGTCACCCAGGT

TGGAGTGCAGTGCTGTGATCTTGGCTCACT

GCAACTTCTGccTCCTGGGTTCAAGCAATT

CTTATGCCTCAGCCTCAGCCTCCTGAGTAG

CTGGGATTACAACACTATGCCCGGGTAATT

TTTGTAI I 1 1 IAGTAGAGACGAGGTTTCGCC

ATGTTGCCCAGACTGGTCTCGAACTCCTGA

CCTCAAGTGATCCACCCGCCTTGGCCTCC

CCACGTGCTGGGATTGCAGGCGTGAGCCA

CTGCGCCCGCCTTGATCTTTACACAAGGG

GTTTAQGGTAGGTAGCCTTCTCTGAACCAG

GAGAACAGCCTGTGCGAAGGCCCTGAGGC

TGGACCGTGCCTGTTGGGTTTGAGGCCGT

TGTAGCTGGAGCAAACAGAGAGAGGGGTA

AAAAGGCAGGAGGCTACCAGGCAGGTTGT

GCAGAGCCTTGTGGGCCACTGGGGAGGA

CTTTGGCTTTTGCCCTGAGAGCGGTGGGA

AGTGACTGAATCCGGTACTCACCGTCTCCC

TCTGGCGGCTCCTGGGGGAACATGCTTGG

GGATCAGGCTGGGGGAGGCTGCCAGGCC

CAGGAGGTGAGAAGTAGGTGGCCTCCAGC

CGTGTTTCCTGA S

Supplementary Table 1

GCGCCCTGAGCCACGGCTCTCTGGGCGC

GGCCATCTTGGTAGATCTGCCGTACAGAAG

GGAAACAGTTGTTCTTGTGTCATTAAACCG

GGATGACTCTCCTGAAAGCAAAAATTTGAG

GCGCAGGAGCAΓΠTCTAG AGTTTATCTGA

ACAAACAGCAATTCATGAATTAGGAAGCATC

ACATTTGTTCACATGTTTΓCCTGCTGACACT CTCCCCACTATTATCCTATTGTCCTGCCACA

Supplementary Table 1

Supplementary Table 1

19 57187615 TCCATCATTTTGCCAAGGCTTCTTTCCTTCA A/G GTTTTAI I 1 1 IGGGCAAAGACGTTCCTATAA G HAP300 46E-06 951E-03 ZNF615 ΪUTR

TTAAATTCTCTGATATTTTCCTAAAAGTCTTC TTATTACATTTCCACGAATTAGTAGTTTATTC

TACATTGAATGTΠTCATAAG I I I I I ICTGCA ATGATCTATGATCACTTCTGAGGGGGTTTAT

ATTAAAAAGCTTTATTGCTCACAAAAAAATAA ATAAATAAAATAGGGTΠTCACTAAAGAGTC ACCTCACACCAAG

Supplementary Table 1

Ch r Position S' Flanking Sequence SNP Base 3' Flanking Sequence Risk chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value S 2 p-value

^{*^}~~~

20 52350615 CTTGTCAACCTGGTTTGAACATTCATTTTAA A/C TAAATCTAGAAGACAAAGAGATAGTACCTTT A Hap300 8.8E-06 7.63E-O3 Intergenic

TAAGACTAATACACATGAATAGTTTTCAAAAA

TGTTGTTAAGGGAAAAATGAGCATTATAAAG

AAGTTAAGTCAGCAGCTAAATAAAAATGCAT

ATGAGATGGCTTTTCTTAACAGGATAGGAC

ACACACAAAGTGTTCTTACATATGTTATCTTA I 1 1 ICACCCA

TTTAATGGTCTTC

CAGATGATGTCACTTCTCTGCTCAAAATCCT

ACAGTGGCTTCCTCGGTCTGTCAGATAAAT

TCCAGAATCCTTATGGTGAAACACAGACAG

CTCTCATCATCTCGACAAACTTCACACTTCC

CTTCTCATAACTCTTTGGGTTTGAACCACCT

GGTGGTCCTTCTGTTCCTAAAACACATCAG

ACACTTTCCAATGTATTGCCTTAAACCCTGC

CTCCGGGTTTCTGTATGACCCTGTGCCTTC

TTTCCTTCAGAGGTCTGTTCTCAACAGAGCA

GCCTTCCCTAACTTCTTATCTGAAATTGCAC

CCTCCACAACCCTGATAATGTTTCCTCCTAG

CACATATCAACTGCCTTGTCGTATAGCTATG

TGATTATTTTGTGCCCCCCACTAAAATGTAA

GGGCATGTGAGAAGGAACTCTCTCTCTTGT

TCATCACTGCATTTCCAACTTCTAGAATAGT

ATAAGACACAAATACCTGTGATAGGCACATA

AATGAATGAACATTATATAAGAGGAAATTTA

GACTTGGAGAGGI I I I

ACAAATAAATAAATACGTGCAACTTAGCAGA AATATGGTATTTTACTATΓTAAGAGCAAACTG GTAATCATGAGATAAACTΠTGATTGACCTT

Supplementary Table 1

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value S 2 p-value rs1293143 20 52351866 TACCAATCAGTAAGAAATCATTGAAAAAACA A/G AGCCAACTCCCCTAATAAATTCCCTCTCATA A HapMO 63E-06 227E-03 lntergenic

AAGAGGGGGGGAAAAAACTCTΓACTTTTAT TATCTATATCTATGTCTATATATGTCTGTGTC

TTAAAGCCCAAAGAAATGTGGACACAAAGA

AATCTAGAAGTAAAACCTCCACAGGGAATG

AGCTCCTCCTAGATGAGCAAGGGCAAAGAA

TGTTTGCATGCTTAGGACCACTTGTTGGGG

TTGGAGATAAGGCAGGCAGATGTGCTATAA

GTGTGAAATACAAACTAGACTCAAAAGGCTT

AGTACCAAAAATATGTGAACTATCTCAACAA

TGACI I I I IATATTGATTGCATATTGAAATTA

TAATACCTTGAATATATTGCATGTGATGGTT

AATTTTAGGTGTCAGCTTGACTGAATGAAG

GAATACCTAGAGAGCTGGTAGAGCACTATG

TCTGGGTGTGCCTGTGAGGGAGTTTCCAG

AGGAAACTGGTGCCTGAGTCAATGGACTG

CGTGGGGAAGATCTCCCTCAGTGCGGGTG

GGCACCATACCATGGGCTGGGGGCCAAGA

TAGAATAAAAAAGGAAAGGAAAGGATTTCTT

TTCTATCTCCCCTTCAGAGCTGGGACTCTTT

CTTCCTCCTGCTCCTGGCCATCAGTACTCC

AGGCCCTCTGTCCTGGGTACCCAAGGATTT

GTGCCAGCACCTCCCTGGGTCCTGAAGCA

TTCAGTTTCAGACTGAGGATTATGTCATTGG ATACATATCCTATCAGTTCTGTCTCTATGGG

TTTCCCTGGTTCAGAGGCTTTTGGACTTGA J!

GCTAAGCCATGCTCCCAGCATCCCAGGGG I I I I 1 1 IAT

CTCCAGAATGTAGACGGACTATCATGAGCC

TTCTCAGCTTCCATAATCCTGT TTTACATGGATGGTTTATATrTATrTTAGATA

ATGTTAGACAACAACACACAAAACAACCACC

CTAAATTGTCCAACAAATCACTTATAAAATGC

AACCTTCTTCCTCATTTAATAAI I I I IATGC

42907029 CATGCTCCCAAATCCAACCGTTCCCTCCAA A/G GAGAGGAAGCCTGAAGGCAAAGTTGGGGA A Hap300 9 OE-06 7 16E-03 CR592664 lntergenic

TAATAAAACCTCAAATTCTCTCCTTGCTGGC

CACCTCCGTTCAGAGTTGAGGGAGGGAAG GGTCATTGAGGAGAGGGCACTTCCACTGC

AAACTGCAAACTCATACTAATCCCCTGCCAG

TTTGTCTTAGTTTTCAAAGTGACTCTTCTTAT

AACAGGTGTAACAAGTGAATTGATCATTTCG

GGCAAGGAAACAGAGC

Supplementary Table 1

Supplementary Table 1

Supplementary Table 1

Replication of SNP or region e = DECODE paper (electrons data not available) f = DGI paper g = FUSION paper (electronic data not available) h = wrccc paper i - SF Grant et al , Nat Genet 38 320-3 (2006)

J = J Gudmundsson et al , Nat Genet 39 977-83 (2007)

Supplementary Table 1

SNP Chr Position S' Flanking Sequence SNP Base 3' Flanking Sequence

Notes for Supplementary Table 1

1. Replication of SNP (directly or by imputation) a = DGI imputed SNPs (data from website)

Web site http //www broad mrt edu/diabetes/scandinavs/type2 html File name http //www broad mrt edu/diabetes/scandinavs/

DGI_T2D_results_zscores_3_07 txt File version March 2007 update Download date 31 July 2007 b = WTCCC imputed SNPs (data from website)

Web site httpV/www wtccc org uk/info/summary_stats shtml °°

File name imputation all zip File version 26 June 2007 update Download date 19 July 2007

The pMAX statistic was computed using the allele counts m the downloaded files for patients with type 2 diabetes and control subjects c= DGI imputed SNPs in LD block (data from website)

Web site http //www broad mit.edu/diabetes/scandinavs/type2 html File name http //www broad mrt edu/diabetes/scandinavs/

DGI_T2D_results_zscores_3_07 txt

File version March 2007 update

Download date 31 July 2007 d = WTCCC imputed SNPs in LD block (data from website)

Web site http //www wtccc org uk/info/summary_stats shtml

File name imputation_all zip

Supplementary Table 1

SNP Chf Position 5 Flanking Sequence SNP Base 3 Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value & 2 p-value

File version 26 June 2007 update

Download date 19 July 2007

The pMAX statistic was computed using the allele counts in the downloaded files for patients with type 2 diabetes and control subjects

2. Replication of SNP or genomic region in published manuscripts e = DECODE (Steinthorsdottir et al 2007) f = DGI (Saxena et al 2007) g = FUSION (Scott et al 2007) h = WTCCC (Zeggini et al 2007) i = TCF7L2 report (Grant et al 2006) j = TCF2 report (Gudmundsson et al 2007)

Grant SF, Thorleifsson G, Reyrusdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers πsk of type 2 diabetes Nature genetics 38, 320-323

Supplementary Table 1

SNP Chr Position 5' FlanKlnα Sequence SNP Base 3' Flanking Sequence Risk Chip Stage t P- Join) Stage 1 Gene Location Reference

Allele Value S 2 p-value

Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafhar T₁ Gudb_jartsson D, Agnarsson BA, Baker A, Sigurdsson A,

Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S,

Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kiraber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC,

Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben

KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan

JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR,

Thorsteinsdottir U, Kong A, Stefansson K (2007) Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nature genetics 39, 977-983

Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhom JN, Daly MJ, Hughes TE, Groop L, Altshuler D,

Almgren P, Florez JC, Meyer J, Ardhe K, Bengtsson Bostrom K, Isomaa B, Lettre G, Lindblad U, Lyon HN₁ Melander O, Newton-Cheh C, Nilsson P, Orho-

Melander M, Rastam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holrnkvist J, Lauπla E,

Sjogren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M,

Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chim GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell

S (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science (New York, N.Y 316, 1331-1336 o

Scott LJ, Mohlke KL, Bonnycastle LL, Wilier CJ, Li Y, Duren WL, Erdos MR, Stπngham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetπck KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, VaIIe TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science (New York, N Y 316, 1341- 1345

Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) A variant in CDKALl influences insulin response and risk of type 2 diabetes. Nature genetics 39, 770-775

Supplementary Table 1

Chf Position S* Flanking Sequence SNP Base 3' Flanking Sequence Risk Chip Stage 1 P- Joint Stage 1 Gene Location Reference

Allele Value S 2 p-value

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP,

Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Burton PR, Clayton DG,

Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Davison D, Easton D, Evans D, Leung HT,

Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskvina V, Nikolov I, O'Donovan M C, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop DT, lies MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Mathew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad

00

Supplementary Table 2

Table 1A.

SNP r2 Position on chii SEQ ID NO rs1193179 - 7503868 SEQ_0001 rs1193178 1.000 7504080 SEQ 0002 rs1193177 0.959 7504173 SEQ 0003 rs1193176 1.000 7504272 SEQ 0004

Table 2A.

SNP r2 Position on chr1 SEQ ID NO rs1863668 0.684 55123729 SEQ 0005 rs7549203 0.684 55125382 SEQ_0006 rs11206479 0.539 55126294 SEQ 0007 rs11811244 0.963 55127872 SEQ_0008 rs12016659 0.523 55128796 SEQ 0009 rs11206480 0.523 55128848 SEQ 0010 rs7524689 0.891 55128995 SEQ_0011 rs11206481 0.541 55129616 SEQ_0012 rs7530321 0.963 55130269 SEQ 0013 rs7520033 0.963 55130284 SEQ 0014 rs6701789 0.926 55130997 SEQ 0015 rs11206482 0.548 55131876 SEQ_0016 rs1035816 0.926 55132358 SEQ 0017 rs1035817 0.962 55132950 SEQ~0018 rs10888890 0.962 55133763 SEQ 0019 rs2114574 0.926 55134275 SEQ_0020 rs11206486 0.963 55134295 SEQ 0021 rs658B539 0.924 55136199 SEQ 0022 rs12141463 0.651 55137307 SEQ_0023 rs7539163 0.924 55138462 SEQ_0024 rs7529244 0.926 55138858 SEQ_0025 rs6S81189 0.963 55139932 SEQ_0026 rs6587414 0.926 55141383 SEQ_0027 rs2317948 - 55146464 SEQ_0028 rs1544909 0.626 55153061 SEQ 0029

Table 3A.

SNP r2 Position on chr1 SEQ ID NO rs695620 0.774 95029485 SEQ_0030 rs859104 0.804 95033047 SEQ 0031 rs859101 _ 95036805 SEQ 0032

Table 4A. SNP r2 Position on chr1 SEQ ID NO rs6600673 0.603 120780890 SEQ 0033 rs6600662 0.627 120842832 SEQ_0034 rs 11249433 120892655 SEQ 0035

Table 5A. SNP r2 Position on chr1 SEQ ID NO rs3790793 0.533 196853863 SEQ 0036 rs12071085 0.601 196855087 SEQ_0037 rs16846147 0.557 196859199 SEQ 0038 Supplementary Table 2

rs3790791 0.557 196860915 SEQ 0039 rs16846165 0.695 196863308 SEQ_0040 rs10494809 . 196863741 SEQ 0041 rs12131233 0.697 196866832 SEQ_0042 rs12069085 0.658 196867725 SEQ 0043 rs10494810 0.658 196868239 SEQ_0044

Table 6A.

SNP r2 Position on chr1 SEQ ID NO rs6541240 - 227397313 SEQ_0045

Table 7A.

SNP r2 Position on chii SEQ ID NO rs2543037 0.540 233827463 SEQ 0046 rs12048201 0.533 233827899 SEQ 0047 rs16835155 0.580 233829030 SEQ 0048 rs10925373 0.571 233830690 SEQ_0049 rs2787102 0.509 233830749 SEQ 0050 rs10925374 0.567 233830800 SEQ 0051 rs2787109 0.580 233833199 SEQ_0052 rs9428665 0.560 233834571 SEQ 0053 rs9428376 0.573 233834603 SEQ_0054 rs9428666 0.559 233834620 SEQ 0055 rs2808227 0.573 233834651 SEQ 0056 rs2808228 0.573 233834663 SEQ_0057 rs2050657 0.580 233835117 SEQ 0058 rs12023820 0.617 233837494 SEQ_0059 rs7551196 0.865 233857434 SEQ 0060 rs4290053 0.955 233859977 SEQ 0061 rs12073854 0.618 233861758 SEQ_0062 rs6670163 . 233862625 SEQ_0063 rs10925391 0.909 233866656 SEQ 0064 rs10925394 0.618 233871139 SEQ_0065

Table 8A.

SNP r2 Position on chr2 SEQ ID NO rs11693502 0.502 136642681 SEQ_0066 rs11678022 0.500 136642765 SEQ 0067 rs11681248 0.588 136653808 SEQ_0068 rs932206 - 136659004 SEQ_0069

Table 9A.

SNP r2 Position on chr3 SEQ ID NO rs 1532552 0.702 1437739 SEQ_0070 rs2167468 0.632 1438537 SEQ 0071 rs9873658 0.727 1438666 SEQ_0072 rs9835151 0.727 1438857 SEQ 0073 rs1382862 0.752 1441413 SEQ 0074 rs2167471 0.744 1444092 SEQ_0075 rs9854037 0.631 1444844 SEQ 0076 rs9848527 0.560 1446181 SEQ_0077 rs7616977 0.503 1449968 SEQ 0078 Supplementary Table 2

rs7627169 0.620 1450324 SEQ 0079 rs1037386 - 1453453 SEQ 0080 rs155847 0.613 1455753 SEQ_0081 rs9990133 0.964 1456623 SEQ_0082 rs718559 0.552 1469475 SEQ 0083 rs718558 0.541 1469483 SEQ_0084 rs9825372 0.726 1473979 SEQ_0085 rs12493849 0.633 1478175 SEQ 0086 rs1951451 0.726 1478475 SEQ_0087 rs4502564 0.726 1480763 SEQ_0088 rs9854789 0.660 1485092 SEQ_0089 rs6753848 0.665 1487587 SEQ 0090 rs11713863 0.665 1488667 SEQ 0091 rs11707049 0.665 1489935 SEQ_0092 rs6786404 0.628 1490274 SEQ 0093 rs9310450 0.658 1490643 SEQ 0094 rs9310451 0.665 1490672 SEQ_0095 rs9310453 0.665 1490852 SEQ 0096 rs17039921 0.665 1493064 SEQ_0097

Table 10A

SNP r2 Position on chr3 SEQ ID NO rs552δδ6 0.673 16383538 SEQ 0098 rs557007 0.673 16383994 SEQ_0099 rs4643693 0.890 16398763 SEQ 0100 rs17042200 0.946 16401895 SEQ_0101 rs12629276 . 16403485 SEQ 0102 rs689543 0.741 16406209 SEQ_0103 rs523909 0.769 16406425 SEQ 0104 rs13081740 0.889 16408494 SEQ 0105 rs1864259 0.893 16408523 SEQ_0106 rs4684279 1.000 16409634 SEQ 0107 rs2053776 1.000 16411059 SEQ_0108 rs12488145 0.570 16411729 SEQ 0109 rs13082467 0.946 16412045 SEQ_0110 rs13062819 1.000 16412272 SEQ_0111 rs1594090 0.522 16413851 SEQ 0112 rs735592 0.946 16416667 SEQ~0113 rs4685334 0.794 16423594 SEQ_0114 rs17042252 0.622 16435774 SEQ_0115

Table 11 A.

SNP r2 Position on chr3 SEQ ID NO rs9848415 0.601 45803845 SEQ 0116 rs7544870 0.576 45805890 SEQ 0117 rs1860263 0.600 45807056 SEQ 0118 rs13064991 - 45809815 SEQ_0119

Table 12A.

SNP r2 Position on chr3 SEQ ID NO rs12633693 0.622 163444104 SEQ_0120 rs12493358 0.650 163451664 SEQ_0121 rs11927519 0.579 163455199 SEQ 0122 Supplementary Table 2

rs883441 0.650 163463610 SEQ 0123 rs10936274 0.966 163467122 SEQ 0124 rs9832510 0.967 163472542 SEQ_0125 rs11925201 0.650 163473903 SEQ 0126 rs12635341 0.643 163476410 SEQ 0127 rs16847030 0.840 163479855 SEQ 0128 rs12638460 0.966 163492451 SEQ_0129 rs6441443 1.000 163499147 SEQ 0130 rs7651936 - 163505661 SEQ_0131 rs1844140 0.874 163528272 SEQ_0132 rs11917604 1.000 163541142 SEQ_0133

Table 13A.

SIMP r2 Position on chr3 SEQ ID NO rs7624911 0.944 165760782 SEQ 0134 rs6775672 0.947 165762840 SEQ 0135 rs9868892 0.895 165773791 SEQ_0136 rs9290240 . 165780254 SEQ 0137 rs9815560 0.947 165805885 SEQ 0138 rs10154905 0.947 165808082 SEQ 0139 rs6804759 0.947 165810387 SEQ_0140 rs1913297 0.947 165810690 SEQ 0141 rs9290241 0.947 165816365 SEQ_0142 rs7625485 0.947 165822669 SEQ_0143 rs1478007 0.947 165823065 SEQ_0144 rs6785579 0.947 165827449 SEQ 0145 rs6764888 0.947 165830263 SEQ 0146 rs6802624 0.933 165834641 SEQ_0147 rs11922371 0.945 165835110 SEQ 0148 rs9835555 0.947 165837660 SEQ 0149 rs9858061 0.942 165842402 SEQ_0150 rs9829997 0.646 165844030 SEQ_0151 rs1495046 0.596 165844409 SEQ 0152 rs11925107 0.553 165848150 SEQ_0153 rs1390044 0.553 165852108 SEQ_0154

Table 14A.

SNP r2 Position on chr4 SEQ ID NO rs1874069 0.567 59216675 SEQ 0155 rs7663551 0.668 59242656 SEQ 0156 rs1453926 0.668 59243973 SEQ 0157 rs12651639 0.668 59245004 SEQ_0158 rs12643918 0.668 59245072 SEQ 0159 rs7670591 0.668 59247412 SEQ 0160 rs6818886 0.668 59249178 SEQJ3161 rs6842153 0.668 59249805 SEQ_0162 rs2029740 0.668 59251340 SEQ 0163 rs4865339 0.668 59254386 SEQ_0164 rs1159171 0.668 59263075 SEQ 0165 rs282717 0.743 59275038 SEQ 0166 rs282745 0.750 59293321 SEQ 0167 rs2662836 0.742 59316566 SEQ 0168 rs282729 0.750 59321995 SEQ_0169 rs282705 _ 59343615 SEQ 0170 Supplementary Table 2

rs282709 0.635 59347634 SEQ_0171 rs282710 0.635 59348193 SEQ_0172 rs282716 0.558 59362583 SEQ_0173 rs18S8419 0.563 59553968 SEQ 0174 rs1449043 0.505 59562234 SEQ 0175 rs1562673 0.563 5956611 1 SEQ_0176

Table 15A.

SNP r2 Position on chr4 SEQ ID NO rs10006753 - 81567021 SEQ 0177 rs1458037 0.661 81575910 SEQ_0178

Table 16A.

SNP r2 Position on chr4 SEQ ID NO rs13108940 0.646 99799667 SEQ 0179 rs4599639 0.646 99801210 SEQ 0180 rs4599640 0.646 99801320 SEQ 0181 rs4699343 0.675 99803666 SEQ 0182 rs10002696 0.646 99807848 SEQ_0183 rs10025051 0.646 99807964 SEQ 0184 rs10006366 0.646 99809387 SEQ 0185 rs4699644 0.644 99814723 SEQ 0186 rs2037832 0.646 99816706 SEQ_0187 rs6532742 0.590 99819712 SEQ 0188 rs4699345 0.517 99823684 SEQ 0189 rs6831643 0.583 99833465 SEQ_0190 rs4699348 0.625 99833656 SEQ_0191 rs6837359 0.617 99833736 SEQ 0192 rs11730384 0.516 99834522 SEQ 0193 rs13141997 0.598 99835934 SEQ_0194 rs10018825 0.624 99836081 SEQ 0195 rs13149070 0.652 99836862 SEQ 0196 rs2866017 0.604 99837966 SEQ 0197 rs13137132 0.547 99838949 SEQ_0198 rs7672134 0.623 99839510 SEQ_0199 rs10021296 0.637 99840416 SEQ 0200 rs4699349 0.649 99844135 SEQ 0201 rs1534555 0.681 99845490 SEQ 0202 rs1573478 0.674 99845547 SEQ_0203 rs7678323 0.753 99846346 SEQ 0204 rs2156504 0.589 99847490 SEQ_0205 rs7691465 0.714 99848365 SEQ 0206 rs7669964 0.695 99851756 SEQ_0207 rs6532751 0.962 99854723 SEQ 0208 rs6844261 0.800 99855858 SEQ_0209 rs2866016 . 99861413 SEQ 0210 rs1358548 0.738 99861813 SEQ_0211 rs4699353 0.649 99866311 SEQ_0212 rs1893714 0.649 99867457 SEQ 0213 rs4699354 0.772 99867911 SEQ_0214 rs11943162 0.720 99878073 SEQ_0215 rs846011 0.525 99884270 SEQ 0216 Supplementary Table 2

Table 17A.

SNP r2 Position on chr4 SEQ ID NO rs747110 0.928 153375057 SEQ 0217 rs6535836 0.874 153379897 SEQ_0218 rs13147317 1.000 153388263 SEQ 0219 rs6843300 1.000 153389654 SEQ_0220 rs6535839 1.000 153407519 SEQ 0221 rs2406625 1.000 153414178 SEQ_0222 rs6843947 1.000 153423076 SEQ_0223 rs6823091 . 153427388 SEQ 0224 rs7671283 1.000 153433658 SEQ_0225 rs6848307 0.935 153439853 SEQ 0226 rs10023167 0.785 153442778 SEQ 0227 rs1986740 0.786 153443546 SEQ_0228 rs6535843 0.777 153444172 SEQ 0229 rs11721471 0.712 153446561 SEQ_0230 rs6849420 0.786 153448047 SEQ 0231 rs2406602 0.882 153452373 SEQ 0232 rs16998856 0.832 153452674 SEQ_0233

Table 18A.

SNP r2 Position on chrδ SEQ ID NO rs165401 0.534 143998261 SEQ_0234 rs919726 0.661 144025024 SEQ_0235 rs11744363 0.757 144040681 SEQ_0236 rs10065677 0.757 144050504 SEQ 0237 rs10051221 0.757 144059469 SEQ 0238 rs10041987 0.697 144065147 SEQ_0239 rs7704793 0.756 144065554 SEQ 0240 rs11951969 0.659 144072265 SEQ 0241 rs10476862 0.537 144072386 SEQ_0242 rs2190593 0.537 144081220 SEQ 0243 rs6873082 0.537 144081714 SEQ 0244 rs10068035 0.537 144081903 SEQ 0245 rs10068047 0.537 144081936 SEQ_0246 rs10068108 0.507 144081963 SEQ 0247 rs2041070 0.757 144083568 SEQ 0248 rs11953855 0.531 144095707 SEQ 0249 rs13154970 0.537 144096815 SEQ_0250 rs10053832 0.537 144100185 SEQ 0251 rs7730888 0.521 144102464 SEQ 0252 rs3853465 0.521 144109009 SEQ_0253 rs3853466 0.514 144115729 SEQ_0254 rs1010349 0.521 144116210 SEQ 0255 rs461599 0.519 144117124 SEQ 0256 rs392659 0.516 144117922 SEQ_0257 rs455193 0 521 144118145 SEQ_0258 rs457077 0.509 144118219 SEQ 0259 rs459807 0.540 144118339 SEQJJ260 rs458366 0.547 144118496 SEQ_0261 rs374554 0.626 144118974 SEQ 0262 rs17791107 0.605 144119549 SEQ_0263 rs247570 0.537 144127404 SEQ 0264 rs247572 0.549 144128237 SEQ_0265 rs171585 0.561 144131688 SEQ 0266 Supplementary Table 2

rs10065170 0.788 144135783 SEQ 0267 rs3906524 0.788 144136573 SEQ_0268 rs118783 0.561 144138729 SEQ 0269 rs118784 0.500 144138771 SEQ_0270 rs10071219 0.788 144144542 SEQ_0271 rs4913000 0.539 144148365 SEQ 0272 rs248558 0.500 144155536 SEQ_0273 rs248557 0.561 144157508 SEQJD274 rs248556 0.576 144157532 SEQ 0275 rs389997 0.530 144162238 SEQ_0276 rs173572 0.561 144162907 SEQ_0277 rs248568 0.561 144163286 SEQ 0278 rs248567 0.566 144164494 SEQ 0279 rs482011 0.545 144171104 SEQ 0280 rs423327 0.540 144172332 SEQ 0281 rs10041348 0.788 144173087 SEQ 0282 rs12189216 0.788 144176803 SEQ_0283 rs990701 0.576 144177471 SEQ 0284 rs4577727 0.785 144179960 SEQ 0285 rs2400162 0.788 144181032 SEQ 0286 rs2214997 0.763 144182082 SEQ 0287 rs248577 0.559 144182754 SEQJ3288 rs10045561 0.534 144189072 SEQ 0289 rs10050736 0.554 144189912 SEQ_0290 rs1432746 0.557 144193685 SEQ 0291 rs10060915 0.561 144194024 SEQ_0292 rs10213858 0.788 144197735 SEQ 0293 rs2163748 0.559 144199632 SEQ_0294 rs10070601 0.856 144229206 SEQ_0295 rs17454163 0.613 144234232 SEQ 0296 rs13357903 0.856 144235338 SEQ 0297 rs13167122 0.865 144237999 SEQ 0298 rs9324972 0.876 144240672 SEQ 0299 rs10040705 0.864 144241285 SEQ 0300 rs7712842 - 144247299 SEQ_0301 rs13436784 1.000 144256173 SEQ_0302 rs13355677 0.891 144263062 SEQ_0303 rs11743254 0.888 144265646 SEQ_0304 rs10067954 0.822 144272557 SEQ_0305 rs10070114 0.822 144273603 SEQ_0306 rs11167873 0.508 144276327 SEQ 0307 rs10044798 1.000 144277067 SEQ_0308 rs6894954 0.964 144294556 SEQ 0309 rs6861229 0.963 144296195 SEQ_0310 rs9324973 0.856 144304626 SEQ 0311 rs10476865 0.893 144305920 SEQ_0312 rs10477261 0.689 144306068 SEQ 0313 rs17613806 0.891 144310140 SEQ_0314 rs1476736 0.653 144313655 SEQ 0315 rs11157886 0.522 144364033 SEQJJ316 rs11744715 0.664 144373085 SEQ 0317 rs740475 0.682 144377800 SEQ_0318 rs7705018 0.679 144405404 SEQ_0319

Table 19A. Supplementary Table 2

SNP r2 Position on chr5 SEQ ID NO rs10055677 0.723 144050504 SEQ 0237 rs10051221 0.723 144059469 SEQ_0238 rs10041987 0.663 144065147 SEQ_0239 rs7704793 0.722 144065554 SEQ 0240 rs11951969 0.624 144072265 SEQ 0241 rs10476862 0.553 144072386 SEQ_0242 rs2190593 0.553 144081220 SEQ 0243 rs6873082 0.553 144081714 SEQ 0244 rs10068035 0.553 144081903 SEQ_0245 rs10068047 0.553 144081936 SEQ_0246 rs10068108 0.524 144081963 SEQ 0247 rs2041070 0.723 144083568 SEQ 0248 rs11953855 0.547 144095707 SEQ_0249 rs13154970 0.553 144096815 SEQ_0250 rs10053832 0.553 144100185 SEQ_0251 rs459807 0.505 144118339 SEQ_0260 rs458366 0.509 144118496 SEQ 0261 rs374554 0.586 144118974 SEQ 0262 rs17791107 0.570 144119549 SEQ_0263 rs247570 0.500 144127404 SEQ_0264 rs247572 0.508 144128237 SEQ_0265 rs171585 0.525 144131688 SEQ 0266 rs10065170 0.755 144135783 SEQ 0267 rs3906524 0.755 144136573 SEQ_0268 rs118783 0.525 144138729 SEQ 0269 rs10071219 0.755 H4144542 SEQ_0271 rs4913000 0.502 144148365 SEQ_0272 rs248557 0.525 144157508 SEQ_0274 rs248556 0.539 144157532 SEQ 0275 rs173572 0.525 144162907 SEQ_0277 rs248568 0.525 144163286 SEQ_0278 rs248567 0.525 144164494 SEQ 0279 rs482011 0.508 144171104 SEQ_0280 rs423327 0.505 144172332 SEQ 0281 rs10041348 0.755 144173087 SEQ 0282 rs12189216 0.755 144176803 SEQ 0283 rs990701 0.539 144177471 SEQ 0284 rs4577727 0.747 144179960 SEQ 0285 rs2400162 0.755 144181032 SEQ_0286 rs2214997 0.727 144182082 SEQ 0287 rs248577 0.522 144182754 SEQ_0288 rs10050736 0.517 144189912 SEQ 0290 rs1432746 0.520 144193685 SEQ 0291 rs10060915 0.525 144194024 SEQ_0292 rs10213858 0.755 144197735 SEQ 0293 rs2163748 0.523 144199632 SEQ_0294 rs10070601 0.823 144229206 SEQ 0295 rs17454163 0.576 144234232 SEQ 0296 rs13357903 0.823 144235338 SEQ 0297 rs13167122 0.828 144237999 SEQ_0298 rs9324972 0.832 144240672 SEQ_0299 rs10040705 0.827 144241285 SEQ_0300 rs7712842 0.964 144247299 SEQ 0301 rs13436784 0.963 144256173 SEQ_0302 rs13355677 0.857 144263062 SEQ 0303 Supplementary Table 2

rs11743254 0.853 144265646 SEQ_0304 rs10067954 0789 144272557 SEQ 0305 rs10070114 0.789 144273603 SEQ_0306 rs10044798 0.964 144277067 SEQ 0308 rs6894954 - 144294556 SEQ 0309 rs6861229 1.000 144296195 SEQ 0310 rs9324973 0823 144304626 SEQ_0311 rs10476865 0.860 144305920 SEQ 0312 rs10477261 0.653 144306068 SEQ_0313 rs17613806 0.857 144310140 SEQ_0314 rs1476736 0 679 144313655 SEQ 0315 rs11167886 0 522 144364033 SEQ 0316 rs11744715 0.720 144373085 SEQ_0317 rs740475 0.644 144377800 SEQ 0318 rs7705018 0.733 144405404 SEQ_0319

Table 2OA

SNP r2 Position on chrβ SEQ ID NO rs4960473 0.511 8930286 SEQ 0320 rs9405431 0.509 8932904 SEQ_0321 rs9406229 0 577 8934563 SEQ 0322 rs9379274 0.593 8935206 SEQ 0323 rs6597377 0.764 8936885 SEQ_0324 rs9505582 0.778 8939853 SEQ 0325 rs2327112 - 8944645 SEQ_0326

Table 21A

SNP r2 Position on chr7 SEQ ID NO rs887847 0.600 7953022 SEQ_0327 rs10280313 0.773 7964390 SEQ_0328 rs3807839 0 511 7965206 SEQ 0329 rs13226206 0.639 7967941 SEQ_0330 rs10282493 - 7969769 SEQ 0331 rs2058519 0.644 7987814 SEQ_0332 rs7804613 0.530 7987906 SEQ_0333

Table 22A.

SNP r2 Position on chrδ SEQ ID NO rs13276304 0.542 20237115 SEQ 0334 rs1021201 0 713 20240373 SEQ 0335 rs7815591 0 713 20240699 SEQ 0336 rs6651486 0 542 20241030 SEQ 0337 rs12544090 0 542 20242704 SEQ 0338 rs10503677 - 20248324 SEQ_0339 rs900956 0.513 20255235 SEQ_0340 rs900955 0631 20255809 SEQ 0341 rs11204110 0.632 20256243 SEQ_0342 rs1872346 0 614 20256683 SEQ_0343 rs4376510 0632 20259350 SEQ 0344 rs2062348 0.632 20260042 SEQ_0345 rs4397421 0.632 20260788 SEQ 0346 rs6586909 0.632 20260832 SEQ 0347 rs4921704 0632 20262371 SEQ 0348 Supplementary Table 2

rs900954 0.632 20262537 SEQ 0349 rs871403 0.663 20263308 SEQ_0350 rs4922163 0.667 20264224 SEQ 0351 rs4921705 0.626 20264821 SEQ_0352 rs4921706 0.632 20265001 SEQ 0353 rs2410641 0.594 20265917 SEQ 0354 rs12549080 0.632 20266185 SEQ_0355 rs10503678 0.632 20266438 SEQ 0356 rs4922167 0.632 20267105 SEQ 0357 rs4922172 0.632 20267464 SEQ_0358 rs13278066 0.632 20268014 SEQ 0359 rs12550451 0.626 20268079 SEQ_0360 rs6985844 0.536 20268359 SEQ 0361 rs12543855 0.632 20268934 SEQJ5362 rs4922173 0 663 20269870 SEQ_0363 rs3892686 0.656 20275192 SEQ 0364 rs1038466 0.663 20277596 SEQ_0365 rs4442161 0.607 20282398 SEQ 0366 rs4922176 0.509 20282855 SEQ_0367 rs9650601 0.632 20285218 SEQ 0368 rs11204111 0.632 20285881 SEQ 0369 rs4922184 0.638 20295408 SEQ_0370 rs2200330 0.663 20299494 SEQ 0371 rs4922185 0.607 20305040 SEQ 0372 rs900951 0.654 20308179 SEQ_0373 rs4921710 0.823 20308883 SEQ 0374 rs885437 0.663 20312188 SEQ 0375 rs4921712 0.663 20314771 SEQ 0376 rs962438 0.591 20317569 SEQJ3377 rs12547668 0.500 20318368 SEQ 0378 rs17491195 0.663 20319492 SEQ_0379 rs13255879 0.663 20320530 SEQ_0380 rs4922188 0.591 20321046 SEQ_0381 rs4922190 0.663 20322594 SEQ_0382 rs13255790 0.663 20325402 SEQ_0383

Table 23A. SNP r2 Position on chrδ SEQ ID NO rs13266634 - 118253964 SEQ_0384 rs3802177 1.000 118254206 SEQ 0385 rs11558471 0.956 118254914 SEQ 0386 rs11774700 0.822 118289451 SEQ_0387

Table 24A.

SNP r2 Position on chr9 SEQ ID NO rs2050831 " 77117950 SEQ_0388

Table 25A.

SNP r2 Position on chr9 SEQ ID NO rs945384 _ 136892579 SEQ 0389

Table 26A. Supplementary Table 2

SNP r2 Position on chriO SEQ ID NO rs10998852 0.611 70975273 SEQ_0390 rs10998854 0.898 70976345 SEQ 0391 rs297050 0.590 70976430 SEQ_0392 rs10823405 0.660 70979963 SEQ 0393 rs10998855 1.000 70980137 SEQ 0394 rs10823406 . 70982029 SEQ_0395 rs297046 0.620 70982827 SEQ 0396 rs192710 0.607 70983142 SEQ 0397 rs11597949 1.000 70983189 SEQ 0398 rs10998857 0.898 70988081 SEQ 0399 rs12781626 0.516 70991180 SEQJMOO

Table 27A

SNP r2 Position on chri O SEQ ID NO rs279B253 0.542 94192885 SEQJM01 rs6583813 0.564 94199919 SEQ 0402 rs11187007 0.561 94204560 SEQ_0403 rs2149632 0.565 94222227 SEQ 0404 rs11187033 0.565 94252339 SEQ 0405 rs10509645 0.565 94267846 SEQ_0406 rs11187078 0.527 94330685 SEQ 0408 rs2421941 0.509 94335889 SEQ 0409 rs3324735 0.535 94344184 SEQ_0411 rs10786050 0.509 94357210 SEQ 0412 rs11187096 0.529 94359568 SEQ_0413 rs7914814 0.509 94372930 SEQ 0414 rs10882095 0.528 94384382 SEQ_0415 rs79D0689 0.509 94385728 SEQ 0416 rs6583830 0.509 94388098 SEQ 0417 rs10BB2096 0.557 94391366 SEQ_0418 rs111B7114 0.521 94396217 SEQ_0419 rs4933734 0.509 94404547 SEQ 0420 rs21 B5756 1.000 94420477 SEQ 0421 rs7911264 0.683 94426831 SEQ_0422 rs2488087 0.692 94436021 SEQ 0423 rs10882100 0.692 94450667 SEQ 0424 rs1111875 - 94452862 SEQ 0425 rs12778642 0.892 94454287 SEQ_0426 rs5015480 1.000 94455539 SEQ 0427 rs10882102 1.000 94456475 SEQ 0428 rs11187144 0.700 94459960 SEQ 0429 rs7087591 0.698 94463609 SEQ_0430 rs10748582 0.698 94467199 SEQ_0431 rs7923837 0.698 94471897 SEQ 0432 rs7923866 0.698 94472056 SEQ_0433

TablB 28A.

SNP r2 Position on chr10 SEQ ID NO rs279B253 0.662 94192885 SEQ_0401 rs65B3813 0.638 94199919 SEQ_0402 rs11187007 0.699 94204560 SEQ 0403 rs2149632 0.702 94222227 SEQ 0404 rs11187033 0.702 94252339 SEQ 0405 Supplementary Table 2

rs105D9645 0.702 94267846 SEQ_0406 rs2421943 0.507 94301795 SEQ 0407 rs11187078 0.665 94330685 SEQ 0408 rs65B3826 0.620 94337810 SEQ_0410 rs3824735 0.671 94344184 SEQ 0411 rs11187096 0.666 94359568 SEQ 0413 rs10882095 0.665 94384382 SEQ 0415 rs10882096 0.683 94391366 SEQ 0418 rs11187114 0.660 94396217 SEQ 0419 rs2185756 0.684 94420477 SEQ_0421 rs1111875 0.698 94452862 SEQ_0425 rs12778642 0.635 94454287 SEQ 0426 rs5015480 0.728 94455539 SEQ 0427 rs10882102 0.728 94456475 SEQ_0428 rs11187144 1.000 94459960 SEQ 0429 rs7087591 1.000 94463609 SEQ_0430 rs10748582 1.000 94467199 SEQ 0431 rs7923837 . 94471897 SEQ 0432 rs7923866 1.000 94472056 SEQ 0433 rs2497306 0.605 94475191 SEQ 0434 rs2488075 0.638 94480154 SEQ_0435 rs2497304 0.554 94482696 SEQ_0436

Table 29A. SNP r2 Position on chr10 SEQ ID NO rs17732523 0.847 102151091 SEQ 0437 rs10883477 0.805 102151386 SEQ 0438 rs10883478 0.805 102152842 SEQ_0439 rs10883479 0.789 102152850 SEQ 0440 rs10786590 0.805 102154594 SEQJD441 rs11190513 0.805 102155228 SEQ 0442 rs3829162 0.805 102162742 SEQ.0443 rs3750723 0.804 102162979 SEQ 0444 rs10883483 0.805 102164234 SEQ 0445 rs4919458 0.805 102167718 SEQ 0446 rs10509743 0.805 102180396 SEQ_0447 rs12360395 0.804 102184064 SEQ 0448 rs872290 0.805 102188869 SEQ_0449 rs11190540 1.000 102192619 SEQ 0450 rs11190541 1.000 102193061 SEQ 0451 rs10883492 1.000 102196079 SEQ 0452 rs11190552 1.000 102196597 SEQ_0453 rs10883493 1.000 102198178 SEQ 0454 rs7085261 1.000 102199801 SEQ_0455 rs7085439 1.000 102200090 SEQ_0456 rs12219789 1.000 102203768 SEQ 0457 rs1539089 1.000 102211414 SEQ_0458 rs3793772 1.000 102212815 SEQ 0459 rs3793771 1.000 102212947 SEQ 0460 rs11190568 1.000 102214267 SEQ_0461 rs11190569 1.000 102217399 SEQ 0462 rs1417823 1.000 102217876 SEQ 0463 rs10883497 1.000 102218509 SEQ 0464 rs7900678 1.000 102219006 SEQ 0465 rs11190573 1.000 102223162 SEQ 0466 rs11190578 _ 102228943 SEQ 0467 Supplementary Table 2

rs2295770 1.000 102229819 SEQ_0468 rs12355721 1.000 102234901 SEQ 0469 rs229B075 1.000 102237398 SEQ_0470 rs3750720 0.887 102238874 SEQ_0471 rs3750719 1.000 102238940 SEQ 0472 rs2273S94 0.942 102246486 SEQ 0473 rs2273695 0.942 102249558 SEQ_0474 rs4804805 0.942 102251399 SEQ 0475 rs7477246 0.942 102251528 SEQ 0476 rs7071271 0.942 102254814 SEQ_0477 rs2295772 0.942 102255173 SEQ_0478 rs2295773 0.940 102255805 SEQ 0479 rs2295774 0.887 102255837 SEQ 0480 rs70B0356 0.942 102256725 SEQ_0481 rs3793706 0.942 102259075 SEQ 0482 rs3763695 0.942 102259196 SEQ_0483 rs10509744 0.940 102261569 SEQ_0484 rs4244338 0.937 102262792 SEQ_0485 rs11190589 0.940 102265461 SEQ 0486 rs3750627 0.937 102265632 SEQ_0487 rs3750629 0.942 102265717 SEQ_0488 rs3750630 0.937 102265770 SEQ_0489 rs3750631 0.940 102269284 SEQ 0490 rs12358187 0.942 102274439 SEQ_0491 rs4919468 0.942 102278333 SEQ_0492 rs1800662 0.942 102279068 SEQ 0493 rs10883506 0.942 102279733 SEQ_0494 rs10883507 0.942 102281265 SEQ 0495 rs10786597 0.942 102281277 SEQ_0496 rs7091356 0.942 102282258 SEQ 0497 rs12354411 0.942 102284527 SEQ 0498 rs2295779 0.942 102286051 SEQ_0499 rs10883509 0.942 102286451 SEQ_0500 rs10883510 0.942 102287008 SEQ 0501 rs11190602 0.942 102287246 SEQ_0502 rs7084810 0.942 102287536 SEQ_0503 rs4919471 0.942 102289229 SEQ 0504 rs10883511 0.821 102289397 SEQ 0505 rs7099965 0.942 102291155 SEQ 0506 rs11190604 0.942 102292447 SEQ_0507 rs12219158 0.937 102292913 SEQ 0508 rs7088827 0.942 102293855 SEQ_0509 rs2295780 0.942 102295955 SEQ 0510 rs7073586 0.942 102297661 SEQ_051 1 rs 10883512 0.942 102298506 SEQ 0512 rs11816840 0.937 102299210 SEQ 0513 rs11292 0.942 102303597 SEQ_0514 rs11190613 0.942 102303987 SEQ_0515 rs4919472 0.782 102305854 SEQ 0516 rs2489034 0.942 102309182 SEQJ3517 rs2489037 0.931 102309908 SEQ 0518 rs2495759 0.816 102310353 SEQ_0519 rs2495753 0.942 102315630 SEQ 0520 rs2495751 0.942 102317250 SEQ 0521 rs2495750 0.937 102317698 SEQ_0522 rs2489039 0.940 102318026 SEQ 0523 Supplementary Table 2

rs2495747 0.940 102318237 SEQ_0524 rs2495745 0.942 102319065 SEQ_0525 rs2495744 0.942 102319399 SEQ 0526 rs9420797 0.942 102321137 SEQ_0527 rs2489040 0.942 102321288 SEQ 0528 rs2495741 0.931 102321785 SEQ_0529 rs2489041 0.798 102323625 SEQ_0530 rs2489043 0.942 102324317 SEQ 0531 rs2495735 0.942 102328599 SEQ 0532 rs2495734 0.940 102328676 SEQ_0533 rs2489045 0.942 102334744 SEQ_0534 rs2489046 0.942 102336272 SEQ 0535 rs9420798 0.942 102337018 SEQ_0536 rs9420801 0.934 102340888 SEQ_0537 rs9420802 0.942 102341775 SEQ_0538 rs2489053 0.942 102343331 SEQ_0539 rs2489001 0.777 102348387 SEQ_0540 rs2489003 0.571 102350845 SEQ_0541

Table 3OA.

SNP r2 Position on chr10 SEQ ID NO rs17747324 0.711 114742493 SEQ 0544 rs7901695 0.798 114744078 SEQ_0545 rs4506565 0.916 114746031 SEQ 0546 rs7903146 - 114748339 SEQ 0547 rs4132670 0.917 114757761 SEQ_0550 rs7904519 0.512 114763917 SEQ_0553 rs12243326 0.688 114778805 SEQ 0558 rs7900150 0.531 114783813 SEQ_0560 rs7100927 0.500 114786038 SEQ 0561 rs7895340 0.500 114791515 SEQ_0562 rs11196205 0.512 114797037 SEQ_0564 rs12255372 0.746 114798892 SEQ 0566 rs12718338 0.512 114803037 SEQ_0570

Table 31 A.

SNP r2 Position on chiϊO SEQ ID NO rs4074720 0.965 114738487 SEQ_0542 rs4074718 0.965 114738607 SEQ 0543 rs7901695 0.519 114744078 SEQ_0545 rs4506565 0.556 114746031 SEQ_0546 rs7903146 0.512 114748339 SEQ 0547 rs10885402 0.964 114751687 SEQ_0548 rs6585198 1.000 114752227 SEQ 0549 rs4132670 0.559 114757761 SEQ 0550 rs6585200 1.000 114758599 SEQ_0551 rs6585201 1.000 114758773 SEQ 0552 rs7904519 - 114763917 SEQ_0553 rs10885405 0.965 114767660 SEQ 0554 rs10885406 0.965 114767714 SEQ_0555 rs10787472 0.965 114771287 SEQ 0556 rs7924080 0.965 114777002 SEQ 0557 rs7077039 0.896 114779067 SEQ_0559 rs7900150 0 965 114783813 SEQ 0560 Supplementary Table 2

rs7100927 0.965 114786038 SEQ 0561 rs7B95340 0.965 114791515 SEQ 0562 rs11196200 0.930 114791928 SEQ_0563 rs11196205 0.930 114797037 SEQ_0564 rs10885409 0.896 114798062 SEQ 0565 rs12265291 0.896 114800230 SEQ 0567 rs11196208 0.890 114801306 SEQ_0568 rs7077247 0.896 114802061 SEQ 0569 rs12718338 0.922 114803037 SEQ_0570

Table 32A.

SNP r2 Position on chM 0 SEQ ID NO rs4074720 0.931 114738487 SEQ_0542 rs4074718 0.931 114738607 SEQ 0543 rs7901695 0.540 114744078 SEQJ3545 rs4506565 0.577 114746031 SEQ 0546 rs7903146 0.531 114748339 SEQ_0547 rs10885402 0.930 114751687 SEQ 0548 rs6585198 0.963 114752227 SEQ 0549 rs4132670 0.580 114757761 SEQ_0550 rs6585200 0.965 114758599 SEQ 0551 rs6585201 0.965 114758773 SEQ 0552 rs7904519 0.965 114763917 SEQ_0553 rs10885405 0.931 114767660 SEQ_0554 rs10885406 0.931 114767714 SEQ_0555 rs10787472 0.931 114771287 SEQ_0556 rs7924080 0.931 114777002 SEQ 0557 rs7077039 0.931 114779067 SEQ_0559 rs7900150 - 114783813 SEQ 0560 rs7100927 1.000 114786038 SEQ 0561 rs7895340 1.000 114791515 SEQ_0562 rs11196200 0.965 114791928 SEQ 0563 rs11196205 0.965 114797037 SEQ 0564 rs10885409 0.931 114798062 SEQJ3565 rs12265291 0.931 114800230 SEQ 0567 rs11196208 0.930 114801306 SEQ_0568 rs7077247 0.931 114802061 SEQ 0569 rs12718338 0.961 114803037 SEQ_0570

Table 33A.

SNP r2 Position on chr10 SEQ ID NO rs4074720 0.933 114738487 SEQ 0542 rs4074718 0.933 114738607 SEQ_0543 rs7901695 0.507 114744078 SEQ 0545 rs4506565 0.543 114746031 SEQ_0546 rs7903146 0 500 114748339 SEQ 0547 rs10885402 0.932 114751687 SEQ 0548 rs6585198 0.964 114752227 SEQ_0549 rs4132670 0.545 114757761 SEQ_0550 rs6585200 0.966 114758599 SEQ_0551 rs6585201 0.966 114758773 SEQ_0552 rs7904519 0.965 114763917 SEQJD553 rs10885405 0.933 114767660 SEQ 0554 rs10885406 0.933 114767714 SEQ 0555 Supplementary Table 2

rs10787472 0.933 114771287 SEQ 0556 rs7924080 0.933 114777002 SEQ 0557 rs7077039 0.931 114779067 SEQ_0559 rs7900150 1.000 114783813 SEQ_0560 rs7100927 - 114786038 SEQ_0561 rs7895340 1.000 114791515 SEQ_0562 rs11196200 0.966 114791928 SEQ 0563 rs11196205 0.965 114797037 SEQ 0564 rs10885409 0.933 114798062 SEQ_0565 rs12265291 0.933 114800230 SEQ_0567 rs11196208 0.928 114801306 SEQ 0568 rs7077247 0.933 114802061 SEQ 0569 rs12718338 0.963 114803037 SEQ 0570

Table 34A. SNP r2 Position on chπ O SEQ ID NO rs4074720 0.932 114738487 SEQ 0542 rs4074718 0.932 114738607 SEQ_0543 rs4505565 0.506 114746031 SEQ 0546 rs10885402 0.931 114751687 SEQ 0548 rs6585198 0.894 114752227 SEQ_0549 rs4132670 0.509 114757761 SEQ 0550 rs6585200 0.899 114758599 SEQ_0551 rs6585201 0.899 114758773 SEQ 0552 rs7904519 0.896 114763917 SEQ 0553 rs10885405 0.932 114767660 SEQ_0554 rs10885406 0.932 114767714 SEQ 0555 rs10787472 0.932 114771287 SEQ_0556 rs7924080 0.932 114777002 SEQ_0557 rs7077039 0.930 114779067 SEQ 0559 rs7900150 0.931 114783813 SEQJD560 rs7100927 0.933 114786038 SEQ 0561 rs7895340 0.933 114791515 SEQ_0562 rs11196200 0.966 114791928 SEQ_0563 rs11196205 0.965 114797037 SEQ 0564 rs10885409 . 114798062 SEQ_0565 rs12265291 1.000 114800230 SEQ 0567 rs11196208 1.000 114801306 SEQ_0568 rs7077247 1.000 114802061 SEQ 0569 rs12718338 0.963 114803037 SEQ_0570 rs11196212 0.517 114811239 SEQ_0571 rs11196213 0.517 114811544 SEQ 0572 rs4918789 0.528 114811797 SEQ_0573 rs7087006 0.517 114813416 SEQ 0574

Table 35A.

SNP r2 Position on chπO SEQ ID NO rs17747324 0.514 114742493 SEQ 0544 rs7901695 0.578 114744078 SEQ_0545 rs4506565 0.680 114746031 SEQ_0546 rs7903146 0.746 114748339 SEQ_0547 rs4132670 0.682 114757761 SEQ 0550 Supplementary Table 2

rs12243326 0.846 114778805 SEQ_0558 rs12255372 - 114798892 SEQ_0566

Table 36A.

SNP r2 Position on chr10 SEQ ID NO rs11196205 0.556 114797037 SEQ_0564 rs10885409 0.528 114798062 SEQ 0565 rs12265291 0.527 114800230 SEQ 0567 rs11196208 0.533 114801306 SEQ_0568 rs7077247 0.528 114802061 SEQ_0569 rs12718338 0.582 114803037 SEQ 0570 rs11196212 1.000 114811239 SEQ 0571 rs11196213 1.000 114811544 SEQ_0572 rs4918789 114811797 SEQ 0573 rs7087006 1.000 114813416 SEQ_0574

Table 37A.

SNP r2 Position on chr10 SEQ ID NO rs1225404 0.776 114904655 SEQ_0575 rs290483 - 114905204 SEQ_0576

Table 38A.

SNP r2 Position on chr11 SEQ ID NO

I-S2442422 1.000 4966456 SEQ 0577 rs2499946 1.000 4967229 SEQ 0578 rs2499953 - 4967481 SEQ_0579 rs2499956 1.000 4968083 SEQ_0580

Table 39A.

SNP r2 Position on chr11 SEQ ID NO rs4445619 0.818 42202178 SEQ_0581 rs7480010 . 42203294 SEQ_0582 rs6485307 0.617 42204903 SEQ_0583 rs7483599 0.541 42212613 SEQ 0584 rs11036787 0.529 42225316 SEQ 0585 rs10837800 0.505 42241041 SEQ_0586

Table 4OA.

SNP r2 Position on crιr11 SEQ ID NO rs178523 0.780 44053802 SEQ_0587 rs178524 0.776 44054576 SEQ_0588 rs178526 0.78 44056574 SEQ_0589 rs178527 0.775 44057422 SEQ_0590 rs178528 0.778 44058135 SEQ 0591 rs178529 0.768 44058657 SEQ 0592 rs4420249 0.778 44060798 SEQ 0593 rs1075983 0.748 44063971 SEQ_0594 rs10838231 0.78 44069549 SEQ 0595 rs3814767 0.78 44072318 SEQ 0596 rs7928476 0.78 44077382 SEQ 0597 rs7935138 0.728 44099510 SEQ 0598 Supplementary Table 2

rs11037880 0.89 44107557 SEQ 0599 rs11037882 0.89 44108153 SEQ_0600 rs7117287 0.89 44109582 SEQ_0601 rs11600929 0.89 44111859 SEQ 0602 rs11600984 0.889 44112201 SEQ 0603 rs4379834 0.89 44115014 SEQ_0604 rs10838240 0.955 44119149 SEQ_0605 rs7118541 0.912 44127521 SEQ 0606 rs4551754 0.886 44128032 SEQ 0607 rs12223543 0.890 44142492 SEQ_0608 rs7120534 0.883 44143978 SEQ 0609 rs10838241 0.905 44146150 SEQ 0610 rs871504 0.89 44156870 SEQ 0611 rs903513 0.944 44156927 SEQ_0612 rs10838244 0.89 44162378 SEQ 0613 rs12792891 0.886 44167904 SEQ_0614 rs1495119 0.961 44181936 SEQ_0615 rs4755236 0.506 44205402 SEQ_0616 rs869915 1 44205901 SEQ 0617 rs12790182 1.000 44207953 SEQ 0618 rs1845618 1 44209913 SEQ 0619 rs1113132 . 44209979 SEQ_0620 rs7945827 1 44211556 SEQ 0621 rs11037909 1 44212190 SEQ_0622 rs3740878 1 44214378 SEQ 0623 rs897007 1 44221074 SEQ 0624 rs1002106 1 44228649 SEQ_0625 rs729287 1 44236666 SEQ 0626 rs7116335 1 44239814 SEQ_0627 rs897004 0.89 44240501 SEQ 0628 rs3802805 0.677 44243142 SEQ_0629

Table 41A.

SNP r2 Position on chr11 SEQ ID NO rs7483599 0.541 42212613 SEQ 0584 rs178523 0.780 44053802 SEQ_0587 rs178524 0.776 44054576 SEQ 0588 rs 178526 0.780 44056574 SEQ 0589 rs178527 0.775 44057422 SEQ_0590 rs178528 0.778 44058135 SEQ 0591 rs178529 0.780 44058657 SEQ 0592 rs4420249 0.778 44060798 SEQ_0593 rs1075983 0.748 44063971 SEQ 0594 rs10838231 0.780 44069549 SEQ_0595 rs3814767 0.780 44072318 SEQ 0596 rs7928476 0.780 44077382 SEQ_0597 rs7935138 0.728 44099510 SEQ 0598 rs11037880 0.890 44107557 SEQ_0599 rs11037882 0.890 44108153 SEQ_0600 rs7117287 0.890 44109582 SEQ_0601 rs11600929 0.890 44111859 SEQ 0602 rs11600984 0.889 44112201 SEQ_0603 rs4379834 0.890 44115014 SEQ 0604 rs10838240 0.890 44119149 SEQ_0605 rs7118541 0.912 44127521 SEQ 0606 Supplementary Table 2

rs4551754 0.886 44128032 SEQ_0607 rs12223543 0.890 44142492 SEQ 0608 rs7120534 0.883 44143978 SEQ_0609 rs10838241 0.905 44146150 SEQ_0610 rs871504 0.890 44156870 SEQ 0611 rs903513 0.944 44156927 SEQ_0612 rs10838244 0.890 44162378 SEQ 0613 rs12792891 0.887 44167904 SEQ 0614 rs1495119 0.961 44181936 SEQ_0615 rs4755236 0.506 44205402 SEQ 0616 rs869915 1.000 44205901 SEQ_0617 rs12790182 1.000 44207953 SEQ 0618 rs1845618 1.000 44209913 SEQ_0619 rs1113132 1.000 44209979 SEQ_0620 rs7945827 1.000 44211556 SEQ 0621 rs11037909 - 44212190 SEQ 0622 rs3740878 1.000 44214378 SEQ 0623 rs897007 1.000 44221074 SEQ 0624 rs1002106 1.000 44228649 SEQ 0625 rs729287 1.000 44236666 SEQ 0626 rs7116335 1.000 44239814 SEQ_0627 rs897004 0.888 44240501 SEQ 0628 rs3802805 0.677 44243142 SEQ_0629

Table 42A.

SNP r2 Position on chr11 SEQ ID NO rs178523 0.780 44053802 SEQ_0587 rs178524 0.776 44054576 SEQ_0588 rs178526 0.780 44056574 SEQ 0589 rs178527 0.775 44057422 SEQ 0590 rs178528 0.778 44058135 SEQ_0591 rs178529 0.780 44058657 SEQ 0592 rs4420249 0.778 44060798 SEQ 0593 rs1075983 0.748 44063971 SEQ_0594 rs10838231 0.780 44069549 SEQ_0595 rs3814767 0.780 44072318 SEQ_0596 rs7928476 0.780 44077382 SEQ 0597 rs7935138 0.728 44099510 SEQ 0598 rs11037880 0.890 44107557 SEQ_0599 rs11037882 0.890 44108153 SEQ 0600 rs7117287 0.890 44109582 SEQ 0601 rs11600929 0.890 44111859 SEQ_0602 rs11600984 0.889 44112201 SEQ 0603 rs4379834 0.890 44115014 SEQ_0604 rs10838240 0.890 44119149 SEQ 0605 rs7118541 0.912 44127521 SEQ 0606 rs4551754 0.886 44128032 SEQ 0607 rs12223543 0.890 44142492 SEQ 0608 rs7120534 0.883 44143978 SEQ 0609 rs10838241 0.905 44146150 SEQ 0610 rs8715O4 0.890 44156870 SEQ_0611 rs903513 0.944 44156927 SEQ_0612 rs10838244 0.890 44162378 SEQ 0613 rs12792891 0.887 44167904 SEQ_0614 rs1495119 0.961 44181936 SEQ 0615 Supplementary Table 2

rs4755236 0.506 44205402 SEQ_0616 rs869915 1.000 44205901 SEQ_0617 rs12790182 1.000 44207953 SEQ_0618 rs1845618 1.000 44209913 SEQ_0619 rs1113132 1 44209979 SEQ_0620 rs7945827 1.000 44211556 SEQ_0621 rs11037909 1.000 44212190 SEQ_0622 rs3740878 44214378 SEQ_0623 rs897007 1.000 44221074 SEQ_0624 rs1002106 1.000 44228649 SEQ_0625 rs729287 1.000 44236666 SEQ_0626 rs7116335 1.000 44239814 SEQ_0627 rs897004 0.888 44240501 SEQ_0628 rs3802805 0.677 44243142 SEQ 0629

Table 43A. SNP r2 Position on chr11 SEQ ID NO rs178523 0.78 44053802 SEQ 0587 rs178524 0.776 44054576 SEQ_0588 rs178526 0.780 44056574 SEQ 0589 rs178527 0.775 44057422 SEQ_0590 rs178528 0.778 44058135 SEQ 0591 rs178529 0.780 44058657 SEQ 0592 rs4420249 0.778 44060798 SEQ 0593 rs1075983 0.748 44063971 SEQ 0594 rs10838231 0.780 44069549 SEQ_0595 rs3814767 0.780 44072318 SEQ_0596 rs7928476 0.780 44077382 SEQ 0597 rs7935138 0.728 44099510 SEQ 0598 rs11037880 0.890 44107557 SEQ 0599 rs11037882 0.890 44108153 SEQ_0600 rs7117287 0.890 44109582 SEQ_0601 rs11600929 0.890 44111859 SEQ_0602 rs11600984 0.889 44112201 SEQ 0603 rs4379834 0.890 44115014 SEQ_0604 rs10838240 0.890 44119149 SEQ 0605 rs7118541 0.912 44127521 SEQ 0606 rs4551754 0.886 44128032 SEQ 0607 rs12223543 0.89 44142492 SEQ_0608 rs7120534 0.883 44143978 SEQJD609 rs10838241 0.905 44146150 SEQ_0610 rs871504 0.890 44156870 SEQ 0611 rs903513 0.944 44156927 SEQ 0612 rs10838244 0.890 44162378 SEQ 0613 rs12792891 0.887 44167904 SEQ_0614 rs1495119 0.961 44181936 SEQ_0615 rs4755236 0.506 44205402 SEQ_0616 rs869915 1.000 44205901 SEQ 0617 rs12790182 1 44207953 SEQ_0618 rs1845618 1.000 44209913 SEQ 0619 rs1113132 1 44209979 SEQ_0620 rs7945827 1.000 44211556 SEQ_0621 rs11037909 1.000 44212190 SEQ 0622 rs3740878 1.000 44214378 SEQ 0623 rs897007 1.000 44221074 SEQ 0624 Supplementary Table 2

rs1002106 1.000 44228649 SEQ 0625 rs729287 44236666 SEQ_0626 rs7116335 1.000 44239814 SEQ_0627 rs897004 0.888 44240501 SEQ_0628 rs3802805 0.677 44243142 SEQ 0629

Table 44A. SNP r2 Position on chπ 1 SEQ ID NO rs4755800 0.545 44244257 SEQ_0630 rs10769024 0.649 44245888 SEQ 0631 rs10769025 0.619 44246011 SEQ 0632 rs11037922 0.819 44246212 SEQ_0633 rs4755802 0.815 44246879 SEQ_0634 rs7949067 44248060 SEQ 0635

Table 45A.

SNP r2 Position on chr11 SEQ ID NO rs1318969 0.551 126027239 SEQ 0636 rs544503 0.613 126028522 SEQ_0637 rs1783988 0.696 126028590 SEQ 0638 rs523249 0.764 126031391 SEQ 0639 rs546252 1.000 126032473 SEQ 0640 rs7950175 . 126033245 SEQ_0641 rs1346306 0.624 126035147 SEQ_0642 rs7113610 0.865 126054506 SEQ 0643 rs4937178 0.558 126058195 SEQ 0644

Table 46A. SNP r2 Position oπ chr12 SEQ ID NO rs709239 0.839 91008608 SEQ 0645 rs1798046 0.850 91013779 SEQ_0646 rs35666 . 91036838 SEQ 0647 rs17251474 0.865 91067786 SEQ 0648 rs7294785 0.716 91083266 SEQ_0649 rs12582672 0.504 91104286 SEQ 0650 rs12824340 0.607 91116967 SEQ_0651 rs17020113 0 553 91118086 SEQ 0652 rs12821466 0.608 91119661 SEQ_0653 rs17790100 0.608 91129962 SEQ 0654 rs12813308 0.608 91130335 SEQ_0655

Table47A.

SNP r2 Position on chrϊ 3 SEQ ID NO rs4884057 0 725 76310078 SEQ 0656 rs9544383 0.861 76311981 SEQ 0657 rs2876711 " 76314505 SEQ_0658

Table 48A. SNP r2 Position on chr14 SEQ ID NO rs8020475 0.655 64723761 SEQ_0659 rs1679885 0.655 64772712 SEQ 0660 Supplementary Table 2

rs12586596 0.540 64783067 SEQ_0661 rs11158584 0.519 64784735 SEQ_0662 rs12100912 0.540 64786391 SEQ_0663 rs1256511 0.928 64804244 SEQ 0664 rs1256513 0.928 64804888 SEQ_0665 rs1256515 0.928 64805110 SEQ_0666 rs1256516 0.928 64805292 SEQ_0667 rs1256517 64805437 SEQ 0668

Table 49A. SNP r2 Position on chr14 SEQ ID NO rs1256519 0.509 64806077 SEQ 0669 rs1256520 0.965 64806946 SEQ_0670 rs1256525 0.965 64808303 SEQ 0671 rs1256526 _ 64809658 SEQ 0672

Table 5OA. SNP r2 Position on chr16 SEQ ID NO rs6499749 0.722 53749781 SEQ 0673 rs4783883 0.688 53750132 SEQ 0674 rs12929336 0.600 53753320 SEQ_0675 rs12930690 0.663 53753511 SEQ 0676 rs982601 0.618 53757536 SEQ_0677 rs17277775 0.633 53757981 SEQ 0678 rs12597742 0.650 53759228 SEQ 0679 rs1156819 0.646 53759882 SEQ 0680 rs11076081 0.650 53764074 SEQ 0681 rs12599100 0.684 53768970 SEQ 0682 rs2589001 - 53776363 SEQ 0683 rs2087105 0.765 53778311 SEQ 0684 rs1486742 0.660 53779181 SEQ_0685 rs2631523 0.684 53779565 SEQ 0686

Table 51 A.

SNP r2 Position on chr17 SEQ ID NO rs11078674 7251197 SEQ 0687

Table 52A.

SNP r2 Position on chr17 SEQ ID NO rs7405696 33176148 SEQ 0688

Table 53A.

SNP r2 Position on chiϊ 7 SEQ ID NO rs162430 1.000 39385935 SEQ 0689 rs231461 - 39388569 SEQ 0690 rs9890045 1.000 39404624 SEQ 0691 rs99O7468 1.000 39407615 SEQ_0692 rs12603224 1.000 39408261 SEQ 0693

Table 54A. Supplementary Table 2

SNP r2 Position on chr17 SEQ ID NO rs8070257 0.557 45796996 SEQ_0694 rs16948935 0.557 45798284 SEQ 0695 rs16948937 0.566 45799938 SEQ_0696 rs17776853 0.566 45801129 SEQ_0697 rs16948951 0.655 45803022 SEQ 0698 rs16948981 0.655 45812250 SEQ_0699 rs917029 0.925 45812566 SEQ 0700 rs917028 0.566 45812608 SEQ 0701 rs12902 0.566 45814180 SEQ_0702 rs10491145 0.566 45817955 SEQ_0703 rs12452992 0.839 45820089 SEQ 0704 rs757509 0.926 45824723 SEQ 0705 rs4794139 0.917 45830075 SEQ_0706 rs1015562 1.000 45838282 SEQ 0707 rs4793654 0.958 45839197 SEQ 0708 rs12451568 0.840 45839885 SEQ_0709 rs9889347 1.000 45840648 SEQ 0710 rs16949053 0.566 45844439 SEQ_0711 rs7211667 - 45844603 SEQ 0712 rs11655508 1.000 45846292 SEQ_0713 rs6504653 1.000 45847135 SEQ 0714

Table 55A.

SNP r2 Position on chr17 SEQ ID NO rs4793514 0.579 66430037 SEQ_0715 rs7223685 0.856 66500336 SEQ 0716 rs1005316 - 66501964 SEQ_0717 rs8080412 1.000 66508046 SEQ 0718 rs758022 0.948 66518601 SEQ 0719

Table 56A.

SNP r2 Position on chr19 SEQ ID NO rs12983082 0.650 11077561 SEQ 0720 rs1003723 0.650 11085181 SEQ 0721 rs5930 - 11085265 SEQ 0722 rs2738446 0.637 11088326 SEQ 0723 rs688 0.637 11088602 SEQ_0724

I-S2738452 0.629 11090218 SEQ_0725 rs4804144 0.545 11097180 SEQ 0726 rs12459476 0.521 11099492 SEQ 0728 rs6413504 0.564 11102915 SEQ 0729 rs4804147 0.540 11117285 SEQ 0730

Table 57A.

SNP r2 Position on chr19 SEQ ID NO rs12983082 0.715 11077561 SEQ_0720 rs1003723 0.715 11085181 SEQJD721 rs5930 0.564 11085265 SEQ 0722 rs2738446 0.813 11088326 SEQ_0723 rs688 0.813 11088602 SEQ 0724 rs2738452 0.825 11090218 SEQ_0725 rs4804144 0.903 11097180 SEQ 0726 Supplementary Table 2

rs2738459 0.547 11099473 SEQ_0727 rs12459476 0.935 11099492 SEQJ3728 rs6413504 11102915 SEQ_0729 rs4804147 0.871 11117285 SEQ 0730

Table 58A.

SNP r2 Position on end 9 SEQ ID NO rs8101509 57100638 SEQ 0731

Table 59A.

SNP r2 Position on chr19 SEQ ID NO rs13343310 1.000 57125279 SEQ 0732 rs7254374 0.659 57127279 SEQ_0733 rs11670350 0.527 57129400 SEQ 0734 rs919779 . 57130159 SEQ 0735 rs11672744 0.527 57145574 SEQ 0736 rs1017379 0.547 57149118 SEQ 0737 rs2015845 0.527 57149591 SEQ_0738 rs8109375 0.527 57151862 SEQ 0739 rs7250159 0.909 57163215 SEQ_0740 rs2278416 0.526 57163376 SEQ_0741 rs2278417 1.000 57163581 SEQ 0742 rs2278418 0.516 57163597 SEQ 0743 rs2278420 0.527 57163684 SEQ 0745 rs7253957 0.573 57165635 SEQ 0746 rs2014187 1 000 57167895 SEQ_0747 rs11668463 0.527 57169792 SEQ_0748 rs11671547 0.839 57177705 SEQ_0749 rs11671769 0.814 57178115 SEQ 0750 rs2288887 0.835 57187615 SEQ_0754 rs16983353 0.835 57187961 SEQ_0755 rs1978717 0.839 57189062 SEQ_0756 rs10500311 0.835 57189755 SEQ 0757 rs1836002 0 835 57190334 SEQ_0758 rs8109926 0.839 57191573 SEQ 0759 rs8103027 0.839 57192954 SEQ_0760 rs8103812 0.835 57193444 SEQ 0761 rs7247405 0.835 57194524 SEQ 0762 rs11084129 0839 57196302 SEQ_0763 rs2903709 0.761 57196732 SEQ_0764 rs2903710 0.547 57199350 SEQ 0765 rs8109948 0.543 57199861 SEQ 0766 rs12461141 0 547 57200777 SEQ_0767 rs12459079 0.547 57200806 SEQ 0768 rs12461230 0.547 57201116 SEQ 0769 rs6509611 0.536 57202018 SEQJ3770 rs8111873 0 547 57209332 SEQ_0771 rs8104890 0.547 57211420 SEQ 0772 rs9636139 0.537 57213108 SEQ 0773 rs12610953 0.547 57213740 SEQ 0774 rs7508453 0.547 57217930 SEQ_0775 rs8112458 0.514 57225117 SEQ 0776

Table 6OA. Supplementary Table 2

SNP r2 Position on chr19 SEQ ID NO rs2278419 57163625 SEQ 0744

Table 61 A.

SNP r2 Position on chr19 SEQ ID NO rs11084127 57187192 SEQ 0752

Table 62A.

SNP r2 Position on chr19 SEQ ID NO rs11084128 57187458 SEQ 0753

Table 63A

SNP r2 Position on chr19 SEQ ID NO rs13343310 0.861 57125279 SEQ_0732 rs7254374 0.5 57127279 SEQ 0733 rs11670350 0.516 57129400 SEQ_0734 rs919779 0 835 57130159 SEQ 0735 rs11672744 0.516 57145574 SEQ 0736 rs1017379 0 535 57149118 SEQ 0737 rs2015845 0.516 57149591 SEQ 0738 rs8109375 0.516 57151862 SEQ 0739 rs7250159 0 774 57163215 SEQ_0740 rs2278416 0 514 57163376 SEQ 0741 rs2278417 0.815 57163581 SEQ 0742 rs2278418 0.504 57163597 SEQ_0743 rs2278420 0.516 57163684 SEQ_0745 rs7253957 0 562 57165635 SEQ 0746 rs2014187 0.835 57167895 SEQ 0747 rs11668463 0.516 57169792 SEQ 0748 rs11671547 1 000 57177705 SEQ_0749 rs11671769 1.000 57178115 SEQ_0750 rs8102072 0.616 57180523 SEQ_0751 rs2288887 . 57187615 SEQ_0754 rs16983353 1 000 57187961 SEQ 0755 rs1978717 1 000 57189062 SEQ 0756 rs10500311 1.000 57189755 SEQ 0757 rs1836002 1.000 57190334 SEQ_0758 rs8109926 1 000 57191573 SEQ 0759 rs8103027 1 000 57192954 SEQ 0760 rs8103812 1 000 57193444 SEQ 0761 rs7247405 1.000 57194524 SEQ_0762 rs11084129 1.000 57196302 SEQ 0763 rs2903709 0.916 57196732 SEQ 0764 rs2903710 0.679 57199350 SEQ 0765 rs8109948 0.687 57199861 SEQ_0766 rs12461141 0.679 57200777 SEQ 0767 rs12459079 0.679 57200806 SEQ 0768 rs12461230 0 679 57201116 SEQ_0769 rs6509611 0 670 57202018 SEQ 0770 rs8111873 0679 57209332 SEQ_0771 rs8104890 0.679 57211420 SEQ_0772 rs9636139 0.671 57213108 SEQ_0773 rs12610953 0679 57213740 SEQ 0774 Supplementary Table 2

rs7508453 0.679 57217930 SEQ_0775 rs8112458 0.599 57225117 SEQ_0776 rs7254131 0.609 57230839 SEQ_0777 rs17779341 0.609 57242213 SEQ_0778 rs11667001 0.548 57244481 SEQ_0779 rs12151270 0.607 57254049 SEQ_0780 rs2869602 0.609 57267389 SEQ_0781 rs9676397 0.590 57271815 SEQ 0782

Table 64A

SNP r2 Position on chr19 SEQ ID NO rs13343310 0.865 57125279 SEQ 0732 rs7254374 0.512 57127279 SEQ.0733 rs11670350 0.527 57129400 SEQ 0734 rs919779 0.839 57130159 SEQ_0735 rs11672744 0.527 57145574 SEQ 0736 rs1017379 0.547 57149118 SEQ 0737 rs2015845 0.527 57149591 SEQ_0738 rs8109375 0.527 57151862 SEQ 0739 rs7250159 0.781 57163215 SEQ_0740 rs2278416 0.526 57163376 SEQ 0741 rs2278417 0.820 57163581 SEQ_0742 rs227B418 0.516 57163597 SEQ_0743 rs2278420 0.527 57163684 SEQ_0745 rs7253957 0.573 57165635 SEQ 0746 rs2014187 0.839 57167895 SEQ 0747 rs11668463 0.527 57169792 SEQ_0748 rs11671547 1.000 57177705 SEQ_0749 rs11671769 1.000 57178115 SEQ 0750 rs8102072 0.592 57180523 SEQ_0751 rs2288887 1.000 57187615 SEQ_0754 rs16983353 1.000 57187961 SEQ_0755 rs1978717 . 57189062 SEQ 0756 rs10500311 1.000 57189755 SEQ_0757 rs1836002 1.000 57190334 SEQ 0758 rs8109926 1.000 57191573 SEQ 0759 rs8103027 1.000 57192954 SEQ 0760 rs8103812 1.000 57193444 SEQ 0761 rs7247405 1.000 57194524 SEQ_0762 rs11084129 1.000 57196302 SEQ 0763 rs2903709 0.918 57196732 SEQ 0764 rs2903710 0.686 57199350 SEQ_0765 rs8109948 0696 57199861 SEQ 0766 rs12461141 0.686 57200777 SEQ 0767 rs12459079 0.686 57200806 SEQ 0768 rs12461230 0.686 57201116 SEQ 0769 rs6509611 0679 57202018 SEQ_0770 rs8111873 0.686 57209332 SEQ 0771 rs8104890 0.686 57211420 SEQ_0772 rs9636139 0.679 57213108 SEQ_0773 rs12610953 0686 57213740 SEQ_0774 rs7508453 0.686 57217930 SEQ_0775 rs8112458 0.609 57225117 SEQ 0776 rs7254131 0.618 57230839 SEQ_0777 rs17779341 0618 57242213 SEQ 0778 Supplementary Table 2

rs11667001 0.559 57244481 SEQ 0779 rs12151270 0.616 57254049 SEQ 0780 rs2869602 0.618 57267389 SEQ_0781 rs9675397 0.600 57271815 SEQ_0782

Table 65A.

SNP r2 Position on chr19 SEQ ID NO rs13343310 0.861 57125279 SEQ 0732 rs7254374 0.501 57127279 SEQ_0733 rs11670350 0.516 57129400 SEQ 0734 rs919779 0.835 57130159 SEQ 0735 rs11672744 0.516 57145574 SEQ 0736 rs1017379 0.535 57149118 SEQ_0737 rs2015845 0 516 57149591 SEQ 0738 rs8109375 0.516 57151862 SEQ~0739 rs7250159 0.775 57163215 SEQ_0740 rs2278416 0.514 57163376 SEQ 0741

I-S2278417 0.816 57163581 SEQ 0742 rs2278418 0.504 57163597 SEQ 0743 rs2278420 0.516 57163684 SEQ 0745 rs7253957 0.562 57165635 SEQ_0746 rs2014187 0.835 57167895 SEQ 0747 rs11658463 0.516 57169792 SEQ 0748 rs11671547 1.000 57177705 SEQ 0749 rs11671769 1.000 57178115 SEQ_0750 rs8102072 0.582 57180523 SEQ_0751 rs2288887 1.000 57187615 SEQ 0754 rs16983353 1.000 57187961 SEQ_0755 rs1978717 1.000 57189062 SEQ 0756 rs10500311 1.000 57189755 SEQ_0757 rs1836002 - 57190334 SEQ_0758 rs8109926 1.000 57191573 SEQ 0759 rs8103027 1.000 57192954 SEQ_0760 rs8103812 1.000 57193444 SEQ 0761 rs7247405 1.000 57194524 SEQ_0762 rs11084129 1.000 57196302 SEQ_0763 rs2903709 0.916 57196732 SEQ 0764 rs2903710 0.679 57199350 SEQ 0765 rs8109948 0.688 57199861 SEQ_0766 rs12461141 0 679 57200777 SEQ 0767 rs 12459079 0.679 57200806 SEQ 0768 rs12461230 0.679 57201116 SEQ 0769 rs6509611 0.671 57202018 SEQ 0770 rs8111873 0.679 57209332 SEQ_0771 rs8104890 0.679 57211420 SEQ 0772 rs9636139 0.671 57213108 SEQ_0773 rs12610953 0.679 57213740 SEQ 0774 rs7508453 0.679 57217930 SEQ_0775 rs8112458 0.600 57225117 SEQJD776 rs7254131 0.609 57230839 SEQ 0777 rs17779341 0.609 57242213 SEQ 0778 rs11667001 0.548 57244481 SEQ 0779 rs12151270 0.608 57254049 SEQ 0780 rs2869602 0.609 57267389 SEQ_0781 rs9676397 0.591 57271815 SEQ 0782 Supplementary Table 2

Table 66A.

SNP r2 Position on chr20 SEQ ID NO rs141 B925 0.609 52259138 SEQ 0783 rs6013925 0.649 52261484 SEQ 0784 rs6127138 0.601 52261791 SEQ_0785 rs51301 0.663 52271678 SEQ 0786 rs292113 0.552 52272845 SEQ_0787 rs2585418 0.635 52277689 SEQ 0788 rs441506 0.693 52284526 SEQ_0789 rs6013938 0.565 52289279 SEQ 0790 rs368933 0.628 52295658 SEQ 0792 rs292123 0.872 52306099 SEQJJ793 rs292125 0.872 52306234 SEQ_0794

TS292126 0.872 52306917 SEQ 0795 rs11266889 0.86 52313911^Λ52313912 SEQ 0796 rs292148 0.556 52328127 SEQ_0797 rs1542522 0.706 52343629 SEQ 0798 rs1542523 0.935 52343709 SEQ 0799 rs2870320 0.706 52349569 SEQ 0800 rs1293144 - 52350615 SEQ_0801 rs1293143 0.739 52351866 SEQ 0802 rs1293140 0.706 52353572 SEQ 0803

Table 67A.

SNP r2 Position on chr20 SEQ ID NO rs1418925 0.594 52259138 SEQ 0783 rs2585418 0.625 52277689 SEQ 0788 rs441506 0.673 52284526 SEQ 0789 rs6013938 0.524 52289279 SEQ 0790 rs2870319 0.614 52294822 SEQ_0791 rs368933 0.639 52295658 SEQ_0792 rs292126 0.634 52306917 SEQ_0795 rs11266889 0.607 52313911^Λ52313912 SEQ 0796 rs292148 0.774 52328127 SEQ_0797 rs1542522 0.967 52343629 SEQJ3798 rs1542523 0.691 52343709 SEQ 0799 rs2870320 0.967 52349569 SEQ 0800 rs1293144 0.739 52350615 SEQ 0801 rs1293143 52351866 SEQ 0802 rs1293135 0.631 52360876 SEQ_0804 rs4809962 0.605 52364555 SEQ 0805

Table 68A.

SNP r2 Position on chr21 SEQ ID NO rs440431 0.551 42905781 SEQ 0806 rs374651 0.908 42906042 SEQ_0807 rs380422 0.908 42906052 SEQ 0808 rs375694 - 42907029 SEQ_0809 rs384716 0.551 42907255 SEQ 0810 rs9653814 0.582 42920363 SEQ 0811 Supplementary Table 2

Table 69A.

SNP r2 Position on chr21 SEQ ID NO rs1888533 - 45825267 SEQ_0812

Table 7OA.

SNP r2 Position on chr22 SEQ ID NO rs7284964 0.528 16918242 SEQ 0813 rs11703744 0.507 16921221 SEQ_0814 rs17809578 0.952 16925566 SEQ 0815 rs426B108 1.000 16926041 SEQ 0816 rs10483096 . 16926334 SEQ_0817 rs17742403 0.949 16928160 SEQ_0818

Table 71 A.

SNP r2 Position on chr22 SEQ ID NO rs6000429 0.673 35546360 SEQ_0819 rs17810645 0.673 35546736 SEQ_0820 rs5756357 0.673 35548173 SEQ_0821 rs5756363 0.673 35549989 SEQ_0822 rs762919 1.000 35554708 SEQ_0823 rs4821540 1.000 35566288 SEQ 0824 rs4821541 1.000 35566394 SEQ_0825 rs5756370 1.000 35566976 SEQ 0826 rs2269513 1.000 35568084 SEQ 0827 rs2269515 1.000 35568739 SEQ 0828 rs10211998 . 35569377 SEQ 0829 rs5756371 1.000 35569520 SEQ_0830 rs11913594 0.692 35570829 SEQ_0831

Table 72A.

SNP r2 Position on chr22 SEQ ID NO rs6000429 0.673 35546360 SEQ_0819 rs17810645 0.673 35546736 SEQ_0820 rs5756357 0.673 35548173 SEQ 0821 rs5756363 0.673 35549989 SEQ 0822 rs762919 1.000 35554708 SEQ 0823 rs4821540 1.000 35566288 SEQ_0824 rs4821541 1.000 35566394 SEQ 0825 rs5756370 1.000 35566976 SEQ_0826 rs2269513 1.000 35568084 SEQ_0827 rs2269515 1.000 35568739 SEQ_0828 rs10211998 1 000 35569377 SEQ_0829 rs5756371 . 35569520 SEQ 0830 rs11913594 0.692 35570829 SEQ_0831

Table 73A.

SNP r2 Position on chr22 SEQ ID NO rs910923 0.569 44808421 SEQ_0832 rs9616111 0.681 44810871 SEQ 0833 rs11702999 0.652 44811345 SEQ 0834 rs13058684 0.664 44811530 SEQ 0835 rs6008955 0.68Θ 44814558 SEQ 0836 Supplementary Table 2

rs873492 44818409 SEQ_0837 rs6007640 1.000 44819953 SEQ_0838 rs910360 0.834 44822824 SEQ_0839 rs3859891 0.964 44824287 SEQ_0840 rs11090910 0.589 44828189 SEQ_0841 rs7288847 0.864 44829702 SEQ_0842 rs6007862 0.831 44832287 SEQ 0843

Table 74A.

SNP r2 Position on chrX SEQ ID NO rs1635209 0.508 3209321 SEQ 0844 rs2694708 0.508 3209583 SEQ_0845 rs764302 0.511 3209687 SEQ_0846 rs1625354 0.511 3214032 SEQ 0847 rs1622778 0.534 3217618 SEQ 0848 rs12848814 0.632 3223395 SEQ 0849 rs1635238 0.644 3225211 SEQ_0850 rs1726206 0.644 3226473 SEQ_0851 rs1635242 0.696 3229085 SEQ 0852 rs5939490 0.696 3230400 SEQ_0853 rs6642197 1.000 3230475 SEQ_0854 rs1635243 1.000 3230945 SEQ 0855 rs1974522 1.000 3232094 SEQ_0856 rs1635247 1.000 3234411 SEQ 0857 rs1635249 0.696 3234678 SEQ 0858 rs1635250 - 3235152 SEQ 0859 rs1635254 1.000 3238565 SEQ_0860 rs5982699 0.604 3260412 SEQ_0861 rs806620 0.506 3273302 SEQ 0862 rs1635197 0.508 3284002 SEQ 0863

Table 75A.

SNP r2 Position on chrX SEQ ID NO rs5984618 - 90079719 SEQ 0864 rs5984058 1.000 90093314 SEQ_0865 rs4893257 1.000 90093552 SEQ 0866 rs4893259 0.835 90112672 SEQ_0867 rs2404259 0.532 90135544 SEQ_0868 rs7053119 0.532 90136228 SEQ 0869 rs932574 0.532 90137677 SEQ_0870 rs932575 0.532 90140631 SEQ 0871

SNP Sequences

Supplementary Table 3

Chr Position 5' Flanking Seαueηce SNP Base 3' Flanking Sequence SEQ ID

1 7503868 CCACCTGGGGGCATGGAAGGGACCCAG A/G GCCATTCTGAAACTTACAGACAATAATCC SEQ_0001

CAGCTGTGCACCGTAGGGTCCCAGCCTC AGAAATAGAGTAAACCAGGAGGGGAAAG

AGGCCTCAGTACG I I I I I ACGGCCAAGT AATGGTACAAGTGTCTGTGGACTATAAAG

TATAAACCTCTGAGAAATGGGGTTTATAA CCTGCTGGGTCCGACAGTTTAGAAATCA

TGGAAACTCTGACACCACCTAAAATACAG AACCCGTGTCACGGTGTTTTCTCTCTGTT

CAGCACTACTGGGTGCTCCCAGAATACA CTGAATCCTGGCTCCCCCGACCCCCAAG

GCCCTAATTTATAAACCACTCAGGGATCC TGTTGCCTGGCTCTGGGGGAGGCAGCT

TG CT

1 7504080 GTGTCAGAGTTTCCATTATAAACCCCATT C/T GGCCTACAACAGAGAACAAGAGGCTAGG SEQ_0002

TCTCAGAGGTTTATAACTTGGCCGTAAAA AGACCTGGGCTTTGCCTCCTGGTGTGAG

ACGTACTGAGGCCTGAGGCTGGGACCCT GGGATGTGGACATGGGGCCTCCCCTTG

ACGGTGCACAGCTGCTGGGTCCCTTCCA CCAGCCAGGAGAGCTATGTGGTCCAAAG

TGCCCCCAGGTGGGGACATCCAGT TCTGCTCATAAAGGATTTTCCATGAGTTC

ACAAGGCCATGAAGCTTTTTAGCAGCCC

AGCGACCAAGGGGGAAAAGCTACACTGA

CTCTCAGTGACCACAACCTCTGTCACTC

CCGAGTCATCCTGCAAAAACAAACAAAC ^

AAACAACAACAAAAAAAAACACTGTCCTC β

CGAGCCATCCAGGCCCCCTTTGTACAAG

CTCCTGACCCAGTGACCCAACAGATACA

TTTCAGACTGATTTTCACATCAGGAGGAG

ATTCCACGCTTGGTACGACGGCACTCGA

GATAACACTCCCCGTTTTCATTAAAGGGC

AAGCTACCAAGGGTCACCTGTTTGGGAT

ATTGAAGGGGTAAAGGCCAACAGTTCTT

AGGTCTAAGGAGTTTGTAAAAAATATGCA

AATGCCTGGGCCCCACCCCCGGGAATTC

TGGTGCCCCA

I-

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs1193177 1 7504173 GTGTCAGAGTTTCCATTATAAACCCCATT A/C GAGCTATGTGGTCCAAAGTCTGCTCATA

TCTCAGAGGTTTATAACTTGGCCGTAAAA AAGGATTTTCCATGAGTTCACAAGGCCAT

ACGTACTGAGGCCTGAGGCTGGGACCCT GAAGCTTTTTAGCAGCCCAGCGACCAAG

ACGGTGCACAGCTGCTGGGTCCCTTCCA GGGGAAAAGCTACACTGACTCTCAGTGA

TGCCCCCAGGTGGGGACATCCAGTTGG CCACAACCTCTGTCACTCCCGAGTCATC

CCTACAACAGAGAACAAGAGGCTAGGAG CTGCAAAAACAAACAAACAAACAACAACA

ACCTGGGCTTTGCCTCCTGGTGTGAGGG AAAAAAAACACTGTCCTCCGAGCCATCC

GATGTGGACATGGGGCCTCCCCTTGCCA AGGCCCCCTTTGTACAAGCTCCTGACCC

GCCAGG AGTGACCCAACAGATACATTTCAGACTGA

TΠTCACATCAGGAGGAGATTCCACGCTT

GGTACGACGGCACTCGAGATAACACTCC

CCGTTTTCATTAAAGGGCAAGCTACCAA

GGGTCACCTGTTTGGGATATTGAAGGGG

TAAAGGCCAACAGTTCTTAGGTCTAAGG . AGTTTGTAAAAAATATGCAAATGCCTGGG CCCCACCCCCGGGAATTCTGGTGCCCCA rs1193176 7504272 GTGTCAGAGTTTCCATTATAAACCCCATT A/C CTGACTCTCAGTGACCACAACCTCTGTC SEQJD004 TCTCAGAGGTTTATAACTTGGCCGTAAAA ACTCCCGAGTCATCCTGCAAAAACAAAC ACGTACTGAGGCCTGAGGCTGGGACCCT AAACAAACAACAACAAAAAAAAACACTGT ACGGTGCACAGCTGCTGGGTCCCTTCCA CCTCCGAGCCATCCAGGCCCCCTTTGTA TGCCCCCAGGTGGGGACATCCAGTTGG CAAGCTCCTGACCCAGTGACCCAACAGA CCTACAACAGAGAACAAGAGGCTAGGAG TACATTTCAGACTGATTTTCACATCAGGA ACCTGGGCTTTGCCTCCTGGTGTGAGGG GGAGATTCCACGCTTGGTACGACGGCAC GATGTGGACATGGGGCCTCCCCTTGCCA TCGAGATAACACTCCCCGTΠTCATTAAA GCCAGGAGAGCTATGTGGTCCAAAGTCT GGGCAAGCTACCAAGGGTCACCTGTTTG GCTCATAAAGGATTTTCCATGAGTTCACA GGATATTGAAGGGGTAAAGGCCAACAGT AGGCCATGAAGC I I I I I AGCAGCCCAGC TCTTAGGTCTMGGAGTTTGTAAAAAATA GACCAAGGGGGAAAAGCTAC TGCAAATGCCTGGGCCCCACCCCCGGG AATTCTGGTGCCCCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1863668 1 55123729 GGGAGACCAGGAAGAAGCTGAGGTTACT G/T CATCAGTCATGGGCTAAGTAGTAGGCAC SEQ_0005

GCA CTGGAAGAAAMTGTTAGAAACTAGAATG

CTCCTGGGGTTTTCTGTAACACAGAGGT

TACTTGGACAAGATCAAATGGTGAACATG

CTGTGTGTGTGTGCACGAACATGTGATT

GATGACCCCCATCCTTCCCTCTGGTAGC

CCGTGCCTGCCCCAGTGGGTCCAGGGA AGAGCAGAGCAAAGCCCTTCCTGCCTGC TCATCAGAGCTGCCCCAGGCTTGAACAC TGGGGTGAGTGAATGCAGGACAACAAGT GTGCTTACTGCCAGGGAAGAGAAGCTGA GCCTTCGGACTGGACTTGGATCTGACCC CCCAACTCCACCTTGAACTAGCTGGGAG AACTTGGGCGAGACTCTGCCCCTCTCTG AGCCTTGGGTCCTTCTTCTATTAAATGAG GAAATTGAATCTACTTCATGGAATTGTTG AGAAGGACCCAGCCCATGGTAGATCTCT AAATATGGGTAGTTTCCCACCCCTTCCG

CCCCTTCATTCTTCCCCACCCTCACCCAT ^

TCTGACGATGCTGGCAGCCA ^

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7549203 1 55125382 TGTTAATGCACCTTGGGACTCTGGTCTTC A/C AGAACAGATCCAGGGCCTGGCTCCTCGA SEQ_0006

CATGAGTTGATGCTGGGCTTTGCACCCC AATCAGGACCTTTGAGAGGAAGAAGAGC

TCCCCCAACCCGAAGAGCTTTTGGGGAT TGCCCATCCTTGCCTGCTTTCATTTTGCC

TTCTTTCCTTTTCTTTTC I I I I I CTTTTGAG ACAGAGTTAAACAAGGCCCAGAGAGGGC

ATGGAGTTTCGCTCTTGTTGCCCAGGCT AAGTGGCTTGCAGGGTTACACAGCAAAC

AGAGTGCAATGGTGTGATCTTGGCTCAC TATGTGGTGGAGACCACACACCCCATTC

CGCAACCTCCGCCTCCCGGGTTCAAGCG AACTGCCATACCCTCCCATCTCCTAGTCT

ATTCTTCCGCCTCAGCCTCCCGAGTAGC TAGACAACTGTCATTAAATACTTTGTATCT

TGGGATTACAGGCATGTGCCACCACACC I I I I I I I I I I I I I I GAGAGTC I I I I I I I I CG

TGGCTAATTTTGTA I I I I I AGTAGAGACC GAGTCTTGCTCTGTCGCCCAGGCTGGAG

GGGTTTCTCCACGTTGGTCAGGCTGGTC TGCAGTGGTGTGATCTCAGCTCACTGCA

TCGAACTTCCGACCATCCGCCTCGGCCT AGCTCCGCCTCTCAGGTTCACGCCATTC

CCTAAAGTGCTGGGATTATAGGCGTGAG TCCTGCCTCAGCGTCCCGAGTAGCTGGG

CTACCACGCCCGGCCTTTGGGATTGATT ACTACAGGTGCCCGCCACCACACCTGGC

TTCAAAGCTAACTTTAGTGTTCATTTTAG TAAI I I I I I GTA I I I I I I I I I AGTAGAGAC

GAAACTAAGGAGAAGAGAAACAAACTCC GGGGTTTCACCAAGTTAGCCAGGATGAT

AGGCTCCTATGATGGAGGCACTGCTTGT CTCAGTCTCCTGACCTTGTGATCCACCT

AAAAGGGCACATACAGACCTCCCAACCA GCCTCGGCCTCCCAAAGTGCTGGGATTA

CCCTAAGATGTAGGCGCTGTTAAAACCC CAGGCGTGAGCCACCATGTCCGGCCAA

AATTTAGAAGAGGAAATTGA I I I I I I I I I I GACTTTGTATACTTTTAACTGTGAAGAGA E

TTCCTGAGACAAAATCTTTCTCTATTGCC GCCCTCCTCCCCTTACTACCAGA '^M

CAGGCTGGAGTACAGTGGTGCCATCTCA GCTCACTGCAACCTTCGTCTCCTGGGTT CAAGCAATTCTCTCTGCCTCAGTCTCCTG AGTAGCTGGGATTACAGGTGCCTGCTGC CATGCCCGGCTAA I I I I I I I GTA I I I I IA GTAGAAGTAGAGTTTCACCATGTTAGCCA GGCTGGTCTCAAACTCCTGACCTCAAGT AATCTACCCACCTCAGCCTCCCAAAGTG CTGGGATTATGGGTGTGAGCCACCGCGC CCGGCTGAGAAGAGGAAATTGAGATGCA GAGAGGGGAAGGTGTATCACTGGTAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs 11206479 1 55126294 ATTCTTGCCTTCTTAATGAGAAAGCTTTC A/G GCATGGTTGGGACAGGCCCTGCCATATG

GTAACAAACTGGTGGCTTCTCAGTGTGTT TACCTTCTTTCCTCTGTTCTTTCTCATGCA TGCAGCTGCTCCAGGTTATGTGGAGATT TTCCCTGCGAGCCAGGTGAGGGCTGGG GTCTGCCCTGCACACAATGACGTCAAGG GTGGGATACTGTATTCGTC I I I I I I I I I I I TTATAATGTCTGCACAACAAACCCACTGA I I I I I I I I I I I I GAGACAGAGTCTTGCTCT GTCTGCCAGACAGGGTGGTTCTACATCG GTCACCCAGGCTGGAGCGCAGTGGCGT CTGGGGTGCACAGGGACCAGCCTAGAA GATCTTGGCTGACTGCAAGCTCCACCTC GA CCGGGTTCATGCCATTCTACTGCCTCAG CCTCCCCAGCAGCTGGGACTATAGGCAC ACGCTGCCATGCCCAGCTAA I I I I I I I GT A N N I ATTAGAGACGGGGTTTCACTGTG TTAGCCAGCACGGTCTCAATCTCCTGAC CTCATGACCCACCCGCCTCGGCCTCCCA AAGTGCTGGGATTACAGGCGTGAGCCAC CGTGCCTGGCCTGTATTAGTTTGTTTTCA CACTGCTAATAAAGACATACCTGAGACTG GGTAATTTATAAAGGAAAGAGATTTAATA GACTCACAGTTCCAC rs11811244 55127872 TATAGTAAGACTATGATTTAAAAATTAAAA C/G GGTGTGGAGAGCTGGTGCAGGCCTGTG SEQ_0008 AAAACTTCTTTACA I I I I I GC I I I I I I GAG AGTGGGGGGGGCTTTGAAGCTGTCCAG ATGCAGTCTCGCACTGTCACCTGGGCTG GGCAGACATATTAGTGGCTTGAACTAGG GAGTGCAATGGCATGATCTCGGCTCACT ACAATGAGCAAGAGGGAGAGAAAGGGA GCAACCTCTGCCTTCCAGGTTCAAGTGA GGGATGCACAAGTTATTTAGGCGTGGTA TTCTCCTGCCTCAGCCTCCAGAGTAGCT ATGGTGGGGCTGGGTGTAGGACGAGGA GGGGTTACAGGTGCCCGCCACCACGCC GGATCCCCGGGGGTGGAAGTGAATGTC CAGCTAA I I I I I I GTA I I I I I AGTAGAGAC ATAGCTAGGCTCGTGGAACTGGGAGGAG GGGGTTTCCCTATGTTGTCCAGGCTGGT GGAGCTGGAGCAGGGAGGGGGATGCGG CTCGAACTCCTGACCTCGCGATCCGCCT CCCTCGCAGGAGCACAGGACATGGCTG GCCTGGGCCTCCCAAAGTGCTGGAGTTA CCCCTGGGATCAGCCTTGGCAGATGGCC CAGGCATGAGCCACCACGCCCGGTCATA AGACGGCCAGTGC TATATTAGTTCTTATATTCCCTTTATATAT CCATCTTGTACATTTTCCCTATTTTCCTCC CTTTTAGTCATGTCCTGGAGTTGGAAACT TGCCCTGGAGTGTTTCAACAAGGAAATTT CCATTGCTCATATTTCCCTTCCAAAAGGT TGACTCTGATCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12016659 1 55128796 GCTGGGATTCTTGCTGTGTTGCTGAACA C/T GGACTCTGACCAAGCGGTGAGACCTCG SEQ_0009

AACAGAACCCTGACTTAGTCTTCACAAGT GGCAAGTCATTTTGCAACCGTCCAGTGG TACGAAACTGACCCAAGGGCTGTGCTGT ATTCACCTTGCCCGCTGCATAGACACAG TTTCAATTCTACCATGCTGCAACTATCCC CCGATTTATTAAGACAGGGGAAATGCAG TCCCGCAGCCTGGGAAACAGGGTAGGAT TGGAGAAAGAGTAATTCATGCAGAGCCG TCCAAGAACAAATAAAGGCCCTCCTTCAA GCTGTGCGGGAGACCGGGGTTTTATTAT CAACCCCATGGCATCCGCCAGCCGCCCA TACTCAAATCCGTCTCCCTGAGCATTTCG ATAGTGC GCGTCAGAG I I I I I AAAGATAATTTGGCA

GGTAGGGGCTTCGGAAGTGGGGAGTGC

TGGTTGGTGAGATTGGAGATGGAATCCT

AGGGGGTCGAAGTGAGTTΠTCTTGCTG

TTTTCTGTTTCTGGGTGGGATGGCAGAA

CTGGTTGAGCCAGATTACCAGTCTGGGT

GGTGTCAGCTGATCCATCGAGTGCAGGG

TCTGCAAAATATTTCAAGCACTAGTCTTA

GCTTTTACAATAGTGATGTTATCCCCAGG AGCAATTTGGGGAGGTTCAGACTGTTGG AGTCAGAGGCTGCATGACTCCC rs 11206480 55128848 GCTGGGATTCTTGCTGTGTTGCTGAACA G/T TGGATTCACCTTGCCCGCTGCATAGACA SEQ_0010 AACAGAACCCTGACTTAGTCTTCACAAGT CAGCCGATTTATTAAGACAGGGGAAATG TACGAAACTGACCCAAGGGCTGTGCTGT CAGTGGAGAAAGAGTAATTCATGCAGAG TTTCAATTCTACCATGCTGCAACTATCCC CCGGCTGTGCGGGAGACCGGGGTTTTAT TCCCGCAGCCTGGGAAACAGGGTAGGAT TATTACTCAAATCCGTCTCCCTGAGCATT TCCAAGAACAAATAAAGGCCCTCCTTCAA TCGGCGTCAGAG I I l I I AAAGATAATTTG CAACCCCATGGCATCCGCCAGCCGCCCA GCAGGTAGGGGCTTCGGAAGTGGGGAG ATAGTGCCGGACTCTGACCAAGCGGTGA TGCTGGTTGGTGAGATTGGAGATGGAAT GACCTCGGGCAAGTCATTTTGCAACCGT CCTAGGGGGTCGAAGTGAGTTTTTCTTG CCA CTGTTTTCTGTTTCTGGGTGGGATGGCA GAACTGGTTGAGCCAGATTACCAGTCTG GGTGGTGTCAGCTGATCCATCGAGTGCA GGGTCTGCAAAATATTTCAAGCACTAGTC TTAGCTTTTACAATAGTGATGTTATCCCC AGGAGCAATTTGGGGAGGTTCAGACTGT TGGAGTCAGAGGCTGCATGACTCCCTAA ACGGTAATTTCTAATCTTATAGATAATTTG TTAGTCCTGCACGGGCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7524689 1 55128995 GATTCTTGCTGTGTTGCTGAACAAACAGA A/G TCAGAG I I I I tAAAGATAATTTGGCAGGT SEQ_0011

ACCCTGACTTAGTCTTCACAAGTTACGAA AGGGGCTTCGGAAGTGGGGAGTGCTGG

ACTGACCCAAGGGCTGTGCTGTTTTCAA TTGGTGAGATTGGAGATGGAATCCTAGG

TTCTACCATGCTGCAACTATCCCTCCCGC GGGTCGAAGTGAG I I I I I CTTGCTGTTTT

AGCCTGGGAAACAGGGTAGGATTCCAAG CTGTTTCTGGGTGGGATGGCAGAACTGG

AACAAATAAAGGCCCTCCTTCAACAACCC TTGAGCCAGATTACCAGTCTGGGTGGTG

CATGGCATCCGCCAGCCGCCCAATAGTG TCAGCTGATCCATCGAGTGCAGGGTCTG

CCGGACTCTGACCAAGCGGTGAGACCTC CAAAATATTTCAAGCACTAGTCTTAGCTT

GGGCAAGTCATTTTGCAACCGTCCAGTG TTACAATAGTGATGTTATCCCCAGGAGCA

GATTCACCTTGCCCGCTGCATAGACACA ATTTGGGGAGGTTCAGACTGTTGGAGTC

GCCGATTTATTAAGACAGGGGAAATGCA AGAGGCTGCATGACTCCCTAAACGGTAA

GTGGAGAAAGAGTAATTCATGCAGAGCC TTTCTAATCTTATAGATAATTTGTTAGTCC

GGCTGTGCGGGAGACCGGGGTTTTATTA TGCACGGGCAGACTGGTCCCCAGGTGA

TTACTCAAATCCGTCTCCCTGAGCATTTC GAAGGAGGTCTTTTCGGGAAAGGGCTAT

GGC TATCAATTTTGTTTCAGAGTCAAGCCATG

AGCTGAATTCCTTCCCAAAGTTAGTTCGG CCTACGCCCAGGAATGAACAAGGACAGC TTAAAGGTTAGAAGCAAGATGGAGTCGG TTAGGTCTGATTTCTTTCACTCTCATAATT

TCCTCAGTTAAAATTTTGCAAAGGTGGTT £

TCAATTTAACCTCTCAGAACCAAGTTTTC ∞

TTCAAGTGGGAAATGGGGATAATAATCAT TCCTCTCTTGTCCTGAGTTAAGATACATG TGAGAAAAAAAAAATCATAGAGTTCGTGG GAGAAGTAAGAGCAAACAGAAGCAGTAC TGTCAGAAGCATTTGAACCAGAGCAATTC CATCTTGAATAGGAGCTGGGTAAAATTAG GCTGAAACCTACTGGCCTGCATTCCCAG AAGGTTAGGCATTCTAAGTCACAGGATG AGATACGAGGTCGGCACAAGATACAGGT AATAAAGACCTTGCTGATACAACAGGTTG CAGTAAAGAAGCCGGCCAAAACCTACTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11206481 1 55129616 TGGGTGGGATGGCAGAACTGGTTGAGC G/T AATCATTCCTCTCTTGTCCTGAGTTAAGA SEQ_0012

CAGATTACCAGTCTGGGTGGTGTCAGCT TACATGTGAGAAAAAAAAAATCATAGAGT

GATCCATCGAGTGCAGGGTCTGCAAAAT TCGTGGGAGAAGTAAGAGCAAACAGAAG

ATTTCAAGCACTAGTCTTAGCTTTTACAA CAGTACTGTCAGAAGCATTTGAACCAGA

TAGTGATGTTATCCCCAGGAGCAATTTG GCAATTCCATCTTGAATAGGAGCTGGGT

GGGAGGTTCAGACTGTTGGAGTCAGAGG AAAATTAGGCTGAAACCTACTGGCCTGC

CTGCATGACTCCCTAAACGGTAATTTCTA ATTCCCAGAAGGTTAGGCATTCTAAGTCA

ATCTTATAGATAATTTGTTAGTCCTGCAC CAGGATGAGATACGAGGTCGGCACAAGA

GGGCAGACTGGTCCCCAGGTGAGAAGG TACAGGTAATAAAGACCTTGCTGATACAA

AGGTCTTTTCGGGAAAGGGCTATTATCAA CAGGTTGCAGTAAAGAAGCCGGCCAAAA

TTTTGTTTCAGAGTCAAGCCATGAGCTGA CCTACTAAAACCAAGATGGCCATGAGAG

ATTCCTTCCCAAAGTTAGTTCGGCCTACG TGACCTCTGGTCGTCCTCACTGCTACAC

CCCAGGAATGAACAAGGACAGCTTAAAG TCCCACCAGCGCCATGACAGTTTACAAA

GTTAGAAGCAAGATGGAGTCGGTTAGGT TGCCACGGTAACGTCAGGAAGTTACCCT

CTGATTTCTΓTCACTCTCATAATTTCCTCA ATATGGTCTAAAAAGGGAAGGCATGAAT

GTTAAAATTTTGCAAAGGTGGTTTCAATT AATCCACCCTTTGTTTAGCATTTCATCAA

TAACCTCTCAGAACCAAGTTTTCTTCAAG GAAATAACTATAAAAATGGGTAACCAGCA

TGGGAAATGGGGATAA GCCCTTGGTGGGCTGCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7530321 1 55130269 ATTCTACCATGCTGCAACTATCCCTCCCG C/G GAGACCACAAAAGGACAATACTGAGGAA SEQ_0013

CAGCCTGGGAAACAGGGTAGGATTCCAA ACCCCTGACCCAAAGGCTAACTTTGGAT

GAACAAATAAAGGCCCTCCTTCAACAAC AAGTTGTGGGGTCCAGGAACACTACTGT

CCCATGGCATCCGCCAGCCGCCCAATAG ATTTTATTAATAAAATGTTTTTATCAGAGC

TGCCGGACTCTGACCAAGCGGTGAGACC CTCCAGAACCCAGCCCTGCACTGCCACC

TCGGGCAAGTCATTTTGCAACCGTCCAG TTGGTTGGATTCCTCCAGCCACATTTACA

TGGATTCACCTTGCCCGCTGCATAGACA GAGCTCACACTCCCCACCTGCCCCCATG

CAGCCGATTTATTAAGACAGGGGAAATG C

CAGTGGAGAAAGAGTAATTCATGCAGAG CCGGCTGTGCGGGAGACCGGGGTΠTAT TATTACTCAAATCCGTCTCCCTGAGCATT

TCGGCGTCAGAG I I I I I AAAGATAATTTG

GCAGGTAGGGGCTTCGGAAGTGGGGAG

TGCTGGTTGGTGAGATTGGAGATGGAAT

CCTAGGGGGTCGAAGTGAGTΠTTCTTG

CTGTTTTCTGTTTCTGGGTGGGATGGCA

GAACTGGTTGAGCCAGATTACCAGTCTG

GGTGGTGTCAGCTGATCCATCGAGTGCA

GGGTCTGCAAAATATTTCAAGCACTAGTC

TTAGCTTTTACAATAGTGATGTTATCCCC C

AGGAGCAATTTGGGGAGGTTCAGACTGT

TGGAGTCAGAGGCTGCATGACTCCCTAA

ACGGTAATTTCTAATCTTATAGATAATTTG

TTAGTCCTGCACGGGCAGACTGGTCCCC

AGGTGAGAAGGAGGTCTTTTCGGGAAAG

GGCTATTATCAATΠTGTTTCAGAGTCAA

GCCATGAGCTGAATTCCTTCCCAAAGTTA

GTTCGGCCTACGCCCAGGAATGAACAAG

GACAGCTTAAAGGTTAGAAGCAAGATGG

AGTCGGTTAGGTCTGATTTCTTTCACTCT

CATAATTTCCTCAGTTAAAATΠTGCAAA

GGTGGTTTCAATTTAACCTCTCAGAACCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7520033 1 55130284 AACTATCCCTCCCGCAGCCTGGGAAACA A/G CAATACTGAGGAAACCCCTGACCCAAAG SEQ_0014

GGGTAGGATTCCAAGAACAAATAAAGGC GCTAACTTTGGATAAGTTGTGGGGTCCA

CCTCCTTCAACAACCCCATGGCATCCGC GGAACACTACTGTATTTTATTAATAAAAT

CAGCCGCCCAATAGTGCCGGACTCTGAC GTTTTTATCAGAGCCTCCAGAACCCAGC

CAAGCGGTGAGACCTCGGGCAAGTCATT CCTGCACTGCCACCTTGGTTGGATTCCT

TTGCAACCGTCCAGTGGATTCACCTTGC CCAGCCACATTTACAGAGCTCACACTCC

CCGCTGCATAGACACAGCCGATTTATTAA CCACCTGCCCCCATGCATGCTGGAGGGA

GACAGGGGAAATGCAGTGGAGAAAGAGT AGG

AATTCATGCAGAGCCGGCTGTGCGGGAG

ACCGGGGTTTTATTATTACTCAAATCCGT

CTCCCTGAGCATTTCGGCGTCAGAGTTT

TTAAAGATAATTTGGCAGGTAGGGGCTT

CGGAAGTGGGGAGTGCTGGTTGGTGAG

ATTGGAGATGGAATCCTAGGGGGTCGAA

GTGAGTTTTTCTTGCTGTTTTCTGTTTCT

GGGTGGGATGGCAGAACTGGTTGAGCC

AGATTACCAGTCTGGGTGGTGTCAGCTG

ATCCATCGAGTGCAGGGTCTGCAAAATA

TTTCAAGCACTAGTCTTAGCTTTTACAAT

AGTGATGTTATCCCCAGGAGCAATTTGG G

GGAGGTTCAGACTGTTGGAGTCAGAGGC ^

TGCATGACTCCCTAAACGGTAATTTCTAA

TCTTATAGATAATTTGTTAGTCCTGCACG

GGCAGACTGGTCCCCAGGTGAGAAGGA

GGTCTTTTCGGGAAAGGGCTATTATCAAT

TTTGTTTCAGAGTCAAGCCATGAGCTGAA

TTCCTTCCCAAAGTTAGTTCGGCCTACGC

CCAGGAATGAACAAGGACAGCTTAAAGG

TTAGAAGCAAGATGGAGTCGGTTAGGTC TGATTTCTTTCACTCTCATAATTTCCTCAG TTAAAATΠTGCAAAGGTGGTTTCAATTTA ACCTCTCAGAACCAAGTTTTCTTCAAGTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6701789 1 55130997 GTTTCCTGCAGGTCTAGGCCTTTGCAAA CfT TCTGCTAAGCCAGAGAATGGCTGGAAGT SEQ_0015

ACCATAACAGGAGTCACTGTCCACTTGAT CAGGTTTGGCTCTGGTAGTTCTCAGATG GACTCAGGGCCTCCTGGACAGGAACCAC CCTGGTATCAGCAGCTCTCTCTGTCTCTT GTGATGTACCTCTCCTTGAATAAAGTTCC TCCAACAGGGATCTCCCCACTGGGAAGT CAGGAAGGGTTTACCTCTGTGCACAAGG ATAGCATTGTGGCCGTGAGCATGTGCTC TTTAGTCTGG N i l ! CTTCTTTGGAGAGA TGAAGCCACACTGGGTTCAATTCCCAGC GACACCAAGTGAGCCTGGCTTTTCCTCG TCTACTTCTTGTTAAAGCTATGTCCACTT A GGTTAAGTGACTTAACTTTACTGTGCCTC AGTTTCCCCGTCTGTAAAATGGGTTGCTC TGAGTATTAAATGAGTTTATTTTGTAAAGT GCTTAGAACAGTGCCCATTATATAATAAC TGGTATGTAAGTGTAGGCTGTTCTGTGTC TCTTCCAGTTGTCTTACTTTGCCCTCTAA GTAGAGATGCAATAGAGAGTGAGGGACA CAAACATTAATAAGGCAGCATGATCT rs11206482 55131876 TGAGGGACACAAACATTAATAAGGCAGC C/T GGCCTTGCCACCTTTGCCACCCTCCAAG SEQ 0016 ATGATCTCTGAAGCACTTTACATATGTAA GGCTCAGAGTGCCCCCCGCCTCAGGTC TTCGTGAAGCTCTTAATATTCATACAAGG CTCTGCATTTGGTGAGCCAACAAAGGAA TAGGCACGCTCACCCGCATTTGGCTTAT GAGGGAGAGCATAGAGGCTTGGAGGGT K* GAGGATACAGAGTCTCATTGTGGGGAAG GGCCTATGAGGAGAGAGACTGTCTGCTT K* TAATTCTTGCAAGGTCACCTCTGCTGTGG CATCTGAATCTCACTCCTGCCCAGGAGA GGAAGCTTCTAAGACCTCAGCACCCTTG CATGAAATGCATGCTTGCTAAACTGAGG GTGGGGCATTCTCTTCTGACCTCCTTGT GGCTCATCATGGGGAAACTTGAAGGACA CTCCTGGCCCAAGGCTGCTAGGCCCTCA CCTAACTCTGCCTGGGAAAGGTGGGTAA GCTGTCTCTCAGTTCACTCCTCACTCTAA GTGTTCAACAAAAAGGGGACATCTTAGT TCTGTCTGGTCTTGGAGTCAGGACAGTC CAGGTCTTGAAGAGTGAATAAGAGTTCT ATCAGGAGTATTAGAGTAAATACACTGCT CTGGATAAGGAGGAG TGCTCTAACAAATAACCTCCGCTCTCAAC ACTTACCACACTGGAGATTACTCACTCAC ATCACAGTTTAATAAAAATCAGGTATGGT GTGTGGGGAGAATCCTGTTCCACACAGT CACTCAAGGACTCAGGATCCTTCCATCTA A

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1035816 1 55132358 GGGCTCATCATGGGGAAACTTGAAGGAC C/T GGAGGTTTCTGTTCCTCCTTGCTTTCTAT SEQ_0017

ACCTAACTCTGCCTGGGAAAGGTGGGTA CCTTCAAGTCCCAGCCCCAGGTTCCTTC AGTGTTCAACAAAAAGGGGACATCTTAGT CCCAGGACTCTAAGATGTGGGAATCCCT CAGGTCTTGAAGAGTGAATAAGAGTTCT CCCTTCTGTCCTCAGAAACACTGATGTTC CTGGATAAGGAGGAGGGAAAGGCATTCT AGGGCATTTTAACCTGGAATGATCCAATG GGGCAGGAGGAACAACGTGTGCAAAGA TGACCTTCACAGCAGCCCAGTGAGGTGG CACATCAGGAAAGTGCCCGGCAGGCAAA AAAGGACATAGGTAATTATAGTCCCCATT GGCAGGACAGGTAAGGAAACAACAGGC GCTTTTATATTCTGATTGTTTATTAGGGG AGAGTCATGGAGTGTGAGGTGGGGGCT CTTATTTCAAAAAGTTGAC I I I I IATTGAA GCAGGGAGGAGGCTGGAGAGGCAAGCA GTTGTATATGGTAAACTTGCTAACTTCAT GAGCTGGACTT CTACAGATGCTTTTGGATTTGCTAGGTAG ACAATCATGTGCAAATAATCACAGTCCTA TTTCTTCCTG I I I I IATTTATTTTCCTTAC CTTATTGCACTAGCGACCATCTCCAATAA AATGTAATACAATCAATGCCAGTGGACAT CCTTGTCTCTTTCCTCATCTCAGTGGGAA AACTTTCAATATTTCACTATTAATTAAAAT ATTTGCTTACAGACATTTAAAATGTTTGCT TAAAAGTAGGTACCTTTTATCAGATTAAA TATTTCCTCTTATTCTAGACTGCTAATTCT K* TAAAAAAATAATAAATCGGCGTTGAATTT TATCAAATGCTTTTCCTCCATCTGGTAAA ATAATCTTATAGA I M I I CTAC I I I I I CTG TTAATGAGATAATCATCAGTGCTTTCATC AGTGGTGCTCAACTGATGTTAA I I I I I CT CTCTAGGGGACATTTGGCAATTTCTGGA GACA I I I I I I ATTAACTCAGCTGGGTGTG TGTGTGTGTGTGTGTGTGATTGGTATTTA GTGCATAGAAGCCAGGGGTGTTGTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

I-S1035817 1 55132950 TCCTCAGAAACACTGATGTTCAGGGCATT A/C ATAAATCGGCGTTGAATTTTATCAAATGC SEQ_0018

TTAACCTGGAATGATCCAATGTGACCTTC TTTTCCTCCATCTGGTAAAATAATCTTATA ACAGCAGCCCAGTGAGGTGGAAAGGAC GA I I I I I CTAC I I I I I CTGTTAATGAGATA ATAGGTAATTATAGTCCCCATTGCTTTTA ATCATCAGTGCTTTCATCAGTGGTGCTCA TATTCTGATTGTTTATTAGGGGCTTATTTC ACTGATGTTAATTTTTCTCTCTAGGGGAC AAAAAGTTGAC I I I I IATTGAAGTTGTATA ATTTGGCAATTTCTGGAGACA I I I I I I ATT TGGTAAACTTGCTAACTTCATCTACAGAT AACTCAGCTGGGTGTGTGTGTGTGTGTG GCTTTTGGATTTGCTAGGTAGACAATCAT TGTGTGATTGGTATTTAGTGCATAGAAGC GTGCAAATAATCACAGTCCTATTTCTTCC CAGGGGTGTTGTTAAACCTTCTACAATGC TG I I I I IATTTATTTTCCTTACCTTATTGC ACAGAAAATGCCCTCCACAACAAAGAAT ACTAGCGACCATCTCCAATAAAATGTAAT GATCCAATAGTGAAGCAGGAAAATAGGT ACAATCAATGCCAGTGGACATCCTTGTCT CTGGAGCCAGGGAACATAAGTCTGATTC CTTTCCTCATCTCAGTGGGAAAACTTTCA ACACTTCAGCTATGACAGGAAATATCCTC ATATTTCACTATTAATTAAAATATTTGCTT TCCATAGGGTGTATGCCAAGTAAATAACT ACAGACATTTAAAATGTTTGCTTAAAAGT TTGTAACTTTACTTCCTCCTCTTCATTTAC AGGTACCTTTTATCAGATTAMTATTTCCT ATAGGGCATAAACCAAGTAACCAGTGAG CTTATTCTAGACTGCTAATTCTTAAAAAAA ATCCTCTCGAGGGTATTTAAACTGCCCAA T AATTCTGTAATGGGGCCCCTGAGCCCCT ATGCTCAGGCCCACTGCCACACTGTGGA GTAAACTTTCATTTTCAGTAAATTTCTTCA TTCTTTCCTTGCTTTGTTTGTGTGTTTTGT CCAATTCTTTGTTCAAGATGCCAAGAACC TGGCCACCCTTCACCGGGAACATATTTT GGTGAGCCTGCCAGGAGAAATTCCAGGA GAAGTTAGGCCCAAAGTTTGGGATTTATT TTTCTCCTTTTCCCTTTTCTTTCTGCTCCA TACAGGGGAATCTGTCTCTGTCTCTCTCT TTTCCTTTCCAACTCAAGACCCTTGGTGG ACAATGCCTAAACACAGAAGCAACTGCA GGTTTCTGGCCATGGTTGGTGAAACTAA GGGGTTCCCATATGGAGGTGCCTAACCG CCACCACCCTGTTCGCTTAAGGGACCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10888890 1 55133763 AATAGGTCTGGAGCCAGGGAACATAAGT AAT ATGCCTAAACACAGAAGCAACTGCAGGT SEQ_0019

CTGATTCACACTTCAGCTATGACAGGAAA TTCTGGCCATGGTTGGTGAAACTAAGGG ^■

TATCCTCTCCATAGGGTGTATGCCAAGTA GTTCCCATATGGAGGTGCCTAACCGCCA

AATAACTTTGTAACTTTACTTCCTCCTCTT CCACCCTGTTCGCTTAAGGGACCAGGGT

CATTTACATAGGGCATAAACCAAGTAACC TG I I I I I I I I I CTTCCCCCTTTC I I I I I CA

AGTGAGATCCTCTCGAGGGTATTTAAACT GTCTTTCAGCCACTATTTCCTAGTAGCTC

GCCCAAAATTCTGTAATGGGGCCCCTGA TTTGGAAATTGAGGGCAATTGGCTGGGG

GCCCCTATGCTCAGGCCCACTGCCACAC TCATTCCCTGGTATTGCCTGAAGGCCAA

TGTGGAGTAAACTTTCATTTTCAGTAAAT GGAGTGAATGGGAATAATTGCCCTAACT

TTCTTCATTCTTTCCTTGCTTTGTTTGTGT GGAAGGGGAAAGGACTCTTTTTTAAAAAA

GTTTTGTCCAATTCTTTGTTCAAGATGCC ATATTTTCTGCTTGTGGTCCCTGGTCCCT

AAGAACCTGGCCACCCTTCACCGGGAAC ACATGTGATCCAGTGCAGAGCAAACTCA

ATATTTTGGTGAGCCTGCCAGGAGAAATT CACGTTTCAGGTGACTTAAACCA I I I I¹TT

CCAGGAGAAGTTAGGCCCAAAGTTTGGG TATGCTAAATTCTTTCCTTCCCCTATTCAA

ATTTA I I I I I CTCCTTTTCCCTTTTCTTTCT CTGGCTAAGGGCAAAAGAAGCCTACCCA

GCTCCATACAGGGGAATCTGTCTCTGTC GCCTCCAGTTCCTATCATTAAAGTTCATG

TCTCTCTTTTCCTTTCCAACTCAAGACCC GAATGGGAAACATGGGAAAGCGTGGCCT

TTGGTGGAC TAACAAATTATAAGG

K* Ul

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2114574 1 55134275 TTTAACCTGGAATGATCCAATGTGACCTT err GGAGATTACACCCAGGTACCGAGAGAAA SEQ_OO2O

CACAGCAGCCCAGTGAGGTGGAAAGGA GCTCATAGTAGGCTCTGGAGGGAAAGCA CATAGGTAATTATAGTCCCCATTGCTTTT TGCAAAGTGGCACCTGTGCCCACCTAAG ATATTCTGATTGTTTATTAGGGGCTTATTT GTCAGAGACTTGTAATACTCTAAGATTGG

V CAAAAAGTTGAC I I I I I ATTGAAGTTGTAT ACCCCACAGGAGGACGGATGCTCCAGG

ATGGTAAACTTGCTAACTTCATCTACAGA GGATCCTACAGACCTCAACCTCCCTGAA TGCTTTTGGATTTGCTAGGTAGACAATCA GGGGATGCTCTTGGCAGAGGTTCTGAGG TGTGCAAATAATCACAGTCCTATTTCTTC TCTAGTAATAAGCCCTCCTTTTAATTTTCT CTGTTTTTATTTATTTTCCTTACCTTATTG CTCACAGTTGCAATGCTGTTTGGACCCA CACTAGCGACCATCTCCAATAAAATGTAA ACATTGTTTGGAATCTGGAGTTTACCGTT TACAATCAATGCCAGTGGACATCCTTGTC GAATGAGAAAGTGGAATGGCATTGCATG TCTTTCCTCATCTCAGTGGGAAAACTTTC TATCCAGGCTTTTGTGCTGCTGTTCTAAG AATATTTCACTATTAATTAAAATATTTGCT AAGGGAGCCTGGTTAATGTGTGACACTC TACAGACATTTAAAATGTTTGCTTAAAAG TCCTTTGGTGCTGTTTGGAGCCCCAGCA TAGGTACCTTTTATCAGATTAAATATTTCC CTCTTTGGAGTCTGGGGAAATTCGGCCT TCTTATTCTAGACTGCTAATTCTTAAAAAA TTAAAAATCAAATTGCCATGGAGACTGCC ATAATAAATCGGCGTTGAATTTTATCAAA TTACGTGAAATTTTGGTTCACAGCCTTCA TGCTTTTCCTCCATCTGGTAAAATAATCT TTGGATTATCTATTGGTGCAAACAAAGTA TATAGA I I I I I CTAC I I I I I CTGTTAATGA AAAACAACGAGCTTGTATTACTGTCTCAT GATAATCATCAGTGCTTTCATCAGTGGTG GGCTAAGGTTCCAAGCTATTGGATCTTTG K* CTCAACTGATGTTAA I I I I I CTCTCTAGG TTTGTGTGTGTATCTACATGTCTTTGTATT GGACATTTGGCAATTTCTGGAGACATTTT GCTGTGAGAAATGGGAAAGTTCTTCTTCA TTATTAACTCAGCTGGGTGTGTGTGTGTG AAGATTATAAAAAGTCATAATTTCTTCTTA TGTGTGTGTGATTGGTATTTAGTGCATAG TAACACTGTTAACCACTATTAGTGTGTAC AAGCCAGGGGTGTTGTTAAACCTTCTAC ATATGTGTGTGTGTATATATATACACATAT AATGCACAGAAAATGCCCTCCACAACAA ATATATTTGATATATATACATATATATTTG AGAATGATCCAATAGTGAAGCAGGAAAA ATATATATATACACATATATATTTGATATA TAGGTCTGGAGCCAGGGAACATAAGTCT TATACACATATATATTTGATATATATATGT GATTCACACTTCAGCTATGACAGGAAATA GTGTATATATATACACATATATATATTTGA TCCTCTCCATAGGGTGTATGCCAAGTAAA TATATATATGTATATATATATATATATTCC TAACTTTGTAACTTTACTTCCTCCTCTTCA AAATCAGCTGTCCTAGCTTGCTCCGGCA TTTACATAGGGCATAAACCAAGTAACCAG TACCTGGACAGAACTAGGCAAGCCCCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11206486 1 55134295 TGGCCATGGπGGTGAAACTAAGGGGTT C/T GAGAGAAAGCTCATAGTAGGCTCTGGAG SEQ_0021

CCCATATGGAGGTGCCTAACCGCCACCA GGAAAGCATGCAAAGTGGCACCTGTGCC

CCCTGTTCGCTTAAGGGACCAGGGTTGT CACCTAAGGTCAGAGACTTGTAATACTCT

I I I I I I I I CTTCCCCCTTTC I I I I I CAGTC AAGATTGGACCCCACAGGAGGACGGATG

TTTCAGCCACTATTTCCTAGTAGCTCTTT CTCCAGGGGATCCTACAGACCTCAACCT

GGAAATTGAGGGCAATTGGCTGGGGTCA CCCTGAAGGGGATGCTCTTGGCAGAGGT

TTCCCTGGTATTGCCTGAAGGCCAAGGA TCTGAGGTCTAGTAATAAGCCCTCCTTTT

GTGAATGGGAATAATTGCCCTAACTGGA AATTTTCTCTCACAGTTGCAATGCTGTTT

AGGGGAAAGGACTC I I I I I I AAAAAAATA GGACCCAACATTGTTTGGAATCTGGAGT

TTTTCTGCTTGTGGTCCCTGGTCCCTACA TTACCGTTGAATGAGAAAGTGGAATGGC

TGTGATCCAGTGCAGAGCAAACTCACAC ATTGCATGTATCCAGGCTTTTGTGCTGCT

GTTTCAGGTGACTTAAACCA I I ! I I I IAT GTTCTAAGAAGGGAGCCTGGTTAATGTG

GCTAAATTCTTTCCTTCCCCTATTCAACT TGACACTCTCCTTTGGTGCTGTTTGGAG

GGCTAAGGGCAAAAGAAGCCTACCCAGC CCCCAGCACTCTTTGGAGTCTGGGGAAA

CTCCAGTTCCTATCATTAAAGTTCATGGA TTCGGCCTTTAAAAATCAAATTGCCATGG

ATGGGAAACATGGGAAAGCGTGGCCTTA AGACTGCCTTACGTGAAATΠTGGTTCAC

ACAAATTATAAGGATGCTAAMGTCGGAG AGCCTTCATTGGATTATCTATTGGTGCAA

ATTACACCCAGGTAC ACAAAGTAAAAACAACG

K*

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6588539 1 55136199 ATGGTAAACTTGCTAACTTCATCTACAGA A/G GTGGGAGCTGCTTGAGCCTGCCTCCCAT SEQ 0022

TGCTTTTGGATTTGCTAGGTAGACAATCA TCTATTCAAAGTCTCACTAAGATAAATGC TGTGCAAATAATCACAGTCCTATTTCTTC ATATCTAACTGCCTCCTTTGGAAAGGCTA CTG I I I I I ATTTATTTTCCTTACCTTATTG ATCAGAAACTCAAAAGAATACAACCATTT CACTAGCGACCATCTCCAATAAAATGTAA ATCTCACACCTACCTGTGACCTGGAAGC TACAATCAATGCCAGTGGACATCCTTGTC CCCAAGTCCCCTCTCCCGCTTTGAGTTTT TCTTTCCTCATCTCAGTGGGAAAACTTTC CCTGCCTTTCCAGACAGAACCAATGTTCA AATATTTCACTATTAATTAAAATATTTGCT TTTTACATATGTTAATTAATGTCTCATGCC TACAGACATTTAAAATGTTTGCTTAAAAG TCCCTTGTTAAAAGTGAAAGAATTGAGTA TAGGTACCTTTTATCAGATTAAATATTTCC CTGAATGGGATAAATGTTTTAGGTAAACC TCTTATTCTAGACTGCTAATTCTTAAAAAA TTTTGCATAAATTAAAATCTTAAAGTTATT ATAATAAATCGGCGTTGAATTTTATCAAA TTTCATGCTCATTTAATATCTGGGTCATTT TGCTTTTCCTCCATCTGGTAAAATAATCT CCAATTATGAAAGTGTTGTGATATGGGGA TATAGA I I I I I CTAC I I I I I CTGTTAATGA AATATGTTTCTAAAATTGTGGAATTATTCT GATAATCATCAGTGCTTTCATCAGTGGTG TATCTATAAATGCCCATATCTAATAGTTCA CTCAACTGATGTTMTTTTTCTCTCTAGG GGATTTCTTGC I I I I IAGGGTTTCACTAA GGACATTTGGCAATTTCTGGAGACATTTT AATTTTAGCATAAGAATCCTAGTTAACAC TTATTAACTCAGCTGGGTGTGTGTGTGTG ATAATTCTGTGTACAAAATGTGCCCAAAA TGTGTGTGTGATTGGTATTTAGTGCATAG GGGTTATTAGTGAGAAAAAGAATAATTTT AAGCCAGGGGTGTTGTTAAACCTTCTAC GTCTAATTCAGAAGTTATCCAAAAGTTAG K> AATGCACAGAAAATGCCCTCCACAACAA TTCAAATTACAGATTTGAAAAGGTTATTTA AGAATGATCCAATAGTGAAGCAGGAAAA TGAAACAATGTAGTAAGGAACCATTAAGT TAGGTCTGGAGCCAGGGAACATAAGTCT AGTAGGGGAGAAAAATGTGGAAAAAGTT GATTCACACTTCAGCTATGACAGGAAATA TAGATAATAAAATATTCTTTAAAACCTGAT TCCTCTCCATAGGGTGTATGCCAAGTAAA AAAGAATTGGAGACATTTGGCTAATTAAC TAACTTTGTAACTTTACTTCCTCCTCTTCA A I I I I I GTAGTTAAAGCTCTTAGTCTTGAT TTTACATAGGGCATAAACCAAGTAACCAG TAAAATAAAATAAGAAGTATTGGAAGTAT TGAGATCCTCTCGAGGGTATTTAAACTGC TGTAGAAAATGCATCGGCAGTTTGGCAG CCAAAATTCTGTAATGGGGCCCCTGAGC TTC I I I I I I I I I I I I I I I I AATGTAGTTAAG CCCTATGCTCAGGCCCACTGCCACACTG CATGAAGCCAGATTTAGTGTGGAGCCAA TGGAGTAAACTTTCATTTTCAGTAAATTTC ATTTCACATACACACTTGCATTGCTTCAC TTCATTCTTTCCTTGCTTTGTTTGTGTGTT ACCATGTTTACTGTTTGTGTAGATAGTGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12141463 1 55137307 TATTTATGAAACAATGTAGTAAGGAACCA A/G TCTAGTTTTCATTTGTTTGCTGTTTATTCT SEQ_0023

TTAAGTAGTAGGGGAGAAAAATGTGGAA CTGCTAGATTTTGTTTATGTATGCATATAT

AAAGTTTAGATAATAAAATATTCTTTAAAA ATAAAACCATGATG I I I I I IAGCCTGGCA

CCTGATAAAGAATTGGAGACATTTGGCTA TGGTGGCTCATGCCTGTAATCCCAGCAC

ATTAACA I I I I I GTAGTTAAAGCTCTTAGT TTTGGGAGGCTGAGGTGGATGGATCATG

CTTGATTAAAATAAAATAAGAAGTATTGG AGGTCAGGAGTTCAAAACCAGCCTGGCC

AAGTATTGTAGAAAATGCATCGGCAGTTT AAGATGATGAAACCCCGTCTCTACTAAAA

GGCAGTTC I I I I I I I I I I I I I I I IAATGTA ATACAAAAATTAGCTGGGCATGGTGGCA

GTTAAGCATGAAGCCAGATTTAGTGTGG GGAGCCTGTAATCCCAGCTACTTGGGAG

AGCCAAATTTCACATACACACTTGCATTG GCTGAGGCAGAGAACAGCTTGAAGCCAG

CTTCACACCATGTTTACTGTTTGTGTAGA GAGGCAGAGGTTGCAGTGAGCCAAGATC

TAGTGCCGGCACTGGAGTACTTATTGGT GTGCCACTGCACTCCAGCCAGGGTGACA

CACGTGCCTAAAGTGAATTTCTTAATTGC AAGCAAGACTCCATCTCAAGAAACAAAAC

ACAGGATGTATGATGTGGG I I I I I I I I I I AAAACAAMCAAAACAAACCATGATTTTT

I I I I I I GGTGGGGGAGCTCTGTATAACAC TTAGTTTTTAGTGGAAGGCTCTTATTTCA

TATAGCTTCCACAGTAAATTAAGTAGAAA TTCTGTGAATAGTTG I I I I I GTTTCCTATG

AGATTTAGGGTTGTTTTCCTGTTTATTAAT CATTTCTAGCAAGTCATCCTTTGTTTCAT

TTTTGC CTATCTGGAATT

K*

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7539163 1 55138462 TCTACAGATGCTTTTGGATTTGCTAGGTA A/G CTAGGTAAGGCCTGGGGACATGTGGAGT SEQ_0024

GACAATCATGTGCAAATAATCACAGTCCT TGGCCACACCCCTAGCTATGCTGGAAAT ATTTCTTCCTG I I I I IATTTATTTTCCTTAC AATCAGACCTTATTAGCACCTAGCACATA CTTATTGCACTAGCGACCATCTCCAATAA ATTAACATAACTTACTAGATTTTACATTAA AATGTAATACAATCAATGCCAGTGGACAT AATTAAAATTGCTAAGAGCCAGCATTATA CCTTGTCTCTTTCCTCATCTCAGTGGGAA ACATGCAATTAAGACTGCTAGAAACAGTT AACTTTCAATATTTCACTATTAATTAAAAT TTACATGCAAGGTGTGTAAGGACAGTAA ATTTGCTTACAGACATTTAAAATGTTTGCT AATGTGTGGGG I I I I I I I GTCAAAGGTTA TAAAAGTAGGTACCTTTTATCAGATTAAA TAAAAGG I I I I I CCTTCTTTAAAATTTCTG TATTTCCTCTTATTCTAGACTGCTAATTCT AGTCATCATΠTGGCCAAATAAATAATTTA TAAAAAAATAATAAATCGGCGTTGAATTT GTTTCAAAATTGTCTTTCTAATGCCTGGC TATCAAATGCTTTTCCTCCATCTGGTAAA I I I I I AGATGGATCAGAGGCCCCTGAAAA ATAATCTTATAGA I I I I I CTAC I I I I I CTG CATCCAGAAAAGAGGTAAACAGGGTTAT TTAATGAGATAATCATCAGTGCTTTCATC TTAACATGTTTAAGTACACAGGGTTGCCA AGTGGTGCTCAACTGATGTTAA I I I I I CT GAATGATGTCCAGTCTTCTTTAAGTTACA CTCTAGGGGACATTTGGCAATTTCTGGA I I I I I GTAAATAATACTAATATATGTTCCA GACA I I I I I IATTAACTCAGCTGGGTGTG AAATTGTATGAGATTTCTAAAATTCTAACA TGTGTGTGTGTGTGTGTGATTGGTATTTA TCTAAGTGTATTCTATCAATCAATTATAAT GTGCATAGAAGCCAGGGGTGTTGTTAAA TATGGTTATTATGTTAAGTTATAGTAAACC CCTTCTACAATGCACAGAAAATGCCCTCC ACAGAAATAACCAAATTTCCTTTTATAAA ACAACAAAGAATGATCCAATAGTGAAGCA GCTACTAACCCAAGTAGAAAAAAAAGTAA O GGAAAATAGGTCTGGAGCCAGGGAACAT TTAAATACCAAGAAAATACTTTGTCAGAT AAGTCTGATTCACACTTCAGCTATGACAG TTTCATGTTAAACCAGCTGATACTGAAAT GAAATATCCTCTCCATAGGGTGTATGCCA TGTTTAGATATACAGTTTGAATAAACTTCA AGTAAATAACTTTGTAACTTTACTTCCTCC CGGTCTAAGTCGAATTACCTATGATAATC TCTTCATTTACATAGGGCATAAACCAAGT CATCAGTTATCAGTGCTGTGATTTAGAAA AACCAGTGAGATCCTCTCGAGGGTATTT AACAACTGGCACTCAAGAGGATATTAGT AAACTGCCCAAAATTCTGTAATGGGGCC CTAATGTTAATTAAGCATGGCCTTCTGGA CCTGAGCCCCTATGCTCAGGCCCACTGC GAACCAGGATAATCACCTTGTCCTCCCT CACACTGTGGAGTAAACTTTCATTTTCAG GAGTCCTTAAAGATTTTATTATTAAAAGTT TAAATTTCTTCATTCTTTCCTTGCTTTGTT TTGCGTTCCATGACTCATCATGGAAAAGA TGTGTGTTTTGTCCAATTCTTTGTTCAAG TAAAATAATCCAAATTAAATACATTGGTGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7529244 1 55138858 TCTACAGATGCTTTTGGATTTGCTAGGTA A/G GGGTTGCCAGAATGATGTCCAGTCTTCT SEQ_0025

GACAATCATGTGCAAATAATCACAGTCCT TTAAGTTACATTTTTGTAAATAATACTAAT ATTTCTTCCTG I I I I IATTTATTTTCCTTAC ATATGTTCCAAAATTGTATGAGATTTCTAA CTTATTGCACTAGCGACCATCTCCAATAA AATTCTAACATCTAAGTGTATTCTATCAAT AATGTAATACAATCAATGCCAGTGGACAT CAATTATAATTATGGTTATTATGTTAAGTT CCTTGTCTCTTTCCTCATCTCAGTGGGAA ATAGTAAACCACAGAAATAACCAAATTTC AACTTTCAATATTTCACTATTAATTAAAAT CTTTTATAAAGCTACTAACCCAAGTAGAA ATTTGCTTACAGACATTTAAAATGTTTGCT AAAAAAGTAATTAAATACCAAGAAAATAC TAAAAGTAGGTACCTTTTATCAGATTAAA TTTGTCAGATTTTCATGTTAAACCAGCTG TATTTCCTCTTATTCTAGACTGCTAATTCT ATACTGAAATTGTTTAGATATACAGTTTG TAAAAAAATAATAAATCGGCGTTGAATTT AATAAACTTCACGGTCTAAGTCGAATTAC TATCAAATGCTTTTCCTCCATCTGGTAAA CTATGATAATCCATCAGTTATCAGTGCTG ATAATCTTATAGA I I I I I CTAC I I I I I CTG TGATTTAGAAAAACAACTGGCACTCAAGA TTAATGAGATAATCATCAGTGCTTTCATC GGATATTAGTCTAATGTTAATTAAGCATG AGTGGTGCTCAACTGATGTTAA I I I I I CT GCCTTCTGGAGAACCAGGATAATCACCT CTCTAGGGGACATTTGGCAATTTCTGGA TGTCCTCCCTGAGTCCTTAAAGATTTTAT GACA I I I I I IATTAACTCAGCTGGGTGTG TATTAAAAGTTTTGCGTTCCATGACTCAT TGTGTGTGTGTGTGTGTGATTGGTATTTA CATGGAAAAGATAAAATAATCCAAATTAA GTGCATAGAAGCCAGGGGTGTTGTTAAA ATACATTGGTGTGGTAACTTACAAATTAC CCTTCTACAATGCACAGAAAATGCCCTCC AAAAATAGTTTATAACCAATGTTTAGTCC ACAACAAAGAATGATCCAATAGTGAAGCA CATATTCCTGGGAAAACAGTTAAAGCATC GGAAAATAGGTCTGGAGCCAGGGAACAT GGGTACACTTGGTAACCTGATGGGCCAT AAGTCTGATTCACACTTCAGCTATGACAG TTAAACATCTTATAAAGGAATTTCATTCAA GAAATATCCTCTCCATAGGGTGTATGCCA TTGTTATTATCAATGCATATTTTCTGGTTG AGTAAATAACTTTGTAACTTTACTTCCTCC ATAAAAGCTTTCCCATGCAAGAGGGCTG TCTTCATTTACATAGGGCATAAACCAAGT ATGTTATAACAGCAGATCATTATGCTACA AACCAGTGAGATCCTCTCGAGGGTATTT GTGTGTTTTCACTGGGTAAAGAAAGCTTT AAACTGCCCAAAATTCTGTAATGGGGCC TTATGGTTTGAATCTTTTGGGAAGATCAG CCTGAGCCCCTATGCTCAGGCCCACTGC AGAAAGAACTGTTGTTGCCATCCACACTA CACACTGTGGAGTAAACTTTCATTTTCAG CAACAGAACTTCGGGACCTTGAACTTTG TAAATTTCTTCATTCTTTCCTTGCTTTGTT GGTTCATAATCTCACAACTGAGAAGGGT TGTGTGTTTTGTCCAATTCTTTGTTCAAG ATCTCCATATTCTTGGAACTGTGTACCCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6681189 1 55139932 TCTACAGATGCTTTTGGATTTGCTAGGTA G/T TAGAAAAGAGGTCTGTTGTGTGACCTTAT SEQ_0026

GACAATCATGTGCAAATAATCACAGTCCT GGGGTGTACTTTTATTTGTGAAGGAGTTT ATTTCTTCCTG I I I I l ATTTATTTTCCTTAC GCAGCCAGGCTTATACAAGAATAAACTTA

CTTATTGCACTAGCGACCATCTCCAATAA TACTTTGATAGATAAAAGATGAAGGCCCA

AATGTAATACAATCAATGCCAGTGGACAT AAGTAGGTGAGAAACTTTAGTGGTACATA

CCTTGTCTCTTTCCTCATCTCAGTGGGAA TGTTGCCTCATAATCAGTCAGAAACAAAA

AACTTTCAATATTTCACTATTAATTAAAAT CATTGGTTCATTCCTCTTAACCCACATCA

ATTTGCTTACAGACATTTAAAATGTTTGCT TGGGTTAAAGAGAACATTGCCAGGAGGC

TAAAAGTAGGTACCTΠTATCAGATTAAA CTTCATTCTTCTAGAAGGGCATCATTTGT

TATTTCCTCTTATTCTAGACTGCTAATTCT TAGGTCC I I I I I CCATGGTTTAAAGTAAA

TAAAAAAATAATAAATCGGCGTTGAATTT AGAAGCAATGATTAAAAATGTATCCCTCA

TATCAAATGCTTTTCCTCCATCTGGTAAA TGATAGGCTCTATAGCAAATTCTACTGTA

ATAATCTTATAGA I I I I I CTAC I I I I I CTG AAGGACACAAACTAAATTCTCTTGTGAAA

TTAATGAGATAATCATCAGTGCTTTCATC GTTACGATAGAATTGGCTGAACAGAGAT

AGTGGTGCTCAACTGATGTTAAI I I I I CT GTATCTGTGCAGCTGCTGGCACTCATGG

CTCTAGGGGACATTTGGCAATTTCTGGA CCTATGGAGAAAACATCTGGTATTATAGA

GACA I I I I I I ATTAACTCAGCTGGGTGTG AATTCAGTTGTAGTGGATTAACAACGAAA

TGTGTGTGTGTGTGTGTGATTGGTATTTA CTGCTTCTTTAAGTCAACCTTTGATCTATT

GTGCATAGAAGCCAGGGGTGTTGTTAAA TGGTTTTAGGAGGTTTGGTTTATGGGTAC

CCTTCTACAATGCACAGAAAATGCCCTCC CTTGGGTAAGAAGCATACTCTGAATTCTT

ACAACAAAGAATGATCCAATAGTGAAGCA GGTATTATCCTCCCAATAGTAATAATAAT K*

GGAAAATAGGTCTGGAGCCAGGGAACAT AGTCTCCCTGGTGTGCTGTATTCTCTCAA

AAGTCTGATTCACACTTCAGCTATGACAG AGGTTTTAAATGCTTGCATGCAGCCATCT

GAAATATCCTCTCCATAGGGTGTATGCCA CTAGAATGTCATATGGTCTCTCTTCAACT

AGTAAATAACTTTGTAACTTTACTTCCTCC GGAATGACAAAAGCTGAGAGAAATGTAC

TCTTCATTTACATAGGGCATAAACCAAGT AACCGTGAAGACACCACAACCCATGAAT

AACCAGTGAGATCCTCTCGAGGGTATTT GACGGGCTGAGACTGGAAACCAAAAATG

AAACTGCCCAAAATTCTGTAATGGGGCC ATAGTAACTGAGAGTGGTGCTAAGGCCC

CCTGAGCCCCTATGCTCAGGCCCACTGC TAAGTTTTGGTCACACTCTTACCTAAGTG

CACACTGTGGAGTAMCTTTCATTTTCAG AGAACCTGACCAAAAAGGGGGAATATTT

TAAATTTCTTCATTCTTTCCTTGCTTTGTT TAAACAAAATTCTGGGAGGCTATTGTTTT TGTGTGTTTTGTCCAATTCTTTGTTCAAG GGACTAAGCTCATGCACTAAGCCCCAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6687414 1 55141383 CTACAGATGCTπTGGAπTGCTAGGTAG C/T GTAACTTTACTTCACCCTCTTCATTTACA SEQ 0027

ACAATCATGTGCAAATAATCACAGTCCTA CAGGGCATACACCAGCTAACCAGTGGAA

TTTCTTCCTG i I I I IATTTATTTTCCTTAC TCCTCTAGAGGGTATTTAAACTCCCAAAA

CTTATTGCACTAGCGACCATCTCCAATAA ATTCTGTAACAGGGCCCCGGTCCCACAT

AATGTAATACAATCAATGCCAGTGGACAT TGTGGAGTGTACTTTCATTGTCAATAAAA

CCTTGTCTCTTTCCTCATCTCAGTGGGAA TTTCTTCATTCTTTCTTCACTTTGTTTGTG

AACTTTCAATATTTCACTATTAATTAAAAT TGTTTTGTCCAATTCTTTGTTCAAGATGC

ATTTGCTTACAGACATTTAAAATGTTTGCT CAAGGACCTGGACAGCCTCCACCGGTAA

TAAAAGTAGGTACCTTTTATCAGATTAAA CAATAGTGCTGAGGTTGACAAACCCTGA

TATTTCCTCTTATTCTAGACTGCTAATTCT TTTCTGTTGCTTAATA I I I I I C I I I I I I GA

TAAAAAAATAATAAATCGGCGTTGAATTT GACAGGGTCTCACTGTGTTGCCCAGGCT

TATCAAATGCTTTTCCTCCATCTGGTAAA GGAGTGTAGTGGCATAATCATGGCTCAC

ATAATCTTATAGA I I I I I CTAC I I I I I CTG TGCAGCCTCAGTCTCCTGGGCTCAGGTG

TTAATGAGATAATCATCAGTGCTTTCATC ATGCTCTCGCTTCAGCCTCCCAAGTAGC

AGTGGTGCTCAACTGATGTTAATTTTTCT TGGGACTACAGACACATGCCACCACACC

CTCTAGGGGACATTTGGCAATTTCTGGA CAGCTAA I I I I I GTATCTTTTGTAGAAAC

GACA I I I I I I ATTAACTCAGCTGGGTGTG GGTCTCTCCATGTTGCCCAGGCTGGTCT

TGTGTGTGTGTGTGTGTGATTGGTATTTA CGAACTCCTGGCTCAAGCAATTTGCCTA

GTGCATAGAAGCCAGGGGTGTTGTTAAA CGTTGGCCTCCCAAAGTACTGATATTATA

CCTTCTACAATGCACAGAAAATGCCCTCC GGCCTGAGCCACCACACCCACCCCATGT

ACAACAAAGAATGATCCAATAGTGAAGCA TGCTTGATCAACCTTGCACTTTGGAAATA

GGAAAATAGGTCTGGAGCCAGGGAACAT AAACCAACTTGGTTGTAATGTAATATTCT

AAGTCTGATTCACACTTCAGCTATGACAG TTTTATGTATGTATTACTACATCTAATTTT

GAAATATCCTCTCCATAGGGTGTATGCCA C I I I I I I I I GTTTGTTTTGAGACGAAGTCT

AGTAAATAACTTTGTAACTTTACTTCCTCC TGCTCTTGTCACCCAGGCTGGAGTGCAA

TCTTCATTTACATAGGGCATAAACCAAGT TGGCATACTATATCTAATTTTCTAATATTT

AACCAGTGAGATCCTCTCGAGGGTATTT TGTTTAGGATTTGTATCTATGTTCATGAA

AAACTGCCCAAAATTCTGTAATGGGGCC AGAAATTATCCTATA I I I I I CCTCTCATGT

CCTGAGCCCCTATGCTCAGGCCCACTGC AATGTCCTTGTCAGGTΠTGGTATTAATG

CACACTGTGGAGTAAACTTTCATTTTCAG TTGATTTGGTCCCATAAAATGAATTGGAA

TAAATTTCTTCATTCTTTCCTTGCTTTGTT AGTGTTCCTTCTTTTTCAATTCTCTGAAA

TGTGTGTTTTGTCCAATTCTTTGTTCAAG GTGTTTGTGTAAGATAGATGTGTTCTCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2317948 1 551464S4 AGAACAATTTAATCCATTCCAAAGAGGCA G/T TTTCCTGGAGGAGCTGATTCATGAACTG SEQ_0028

TCTTCCCCCTAAATTTGAATATTTCTGATA AGTTTTGCAGGATGAATTCCATGTGTGTG

CCGAGGTTCATTGTTAAGGCCTAATTGG GTGCAGCGAAGAAACACAAGCAAAAATG

CAGCATCCTTTCTTTCTTGGTGGCACACG TGGAGCAACTCTGTCCACATGTGGAGTC

AACTAATGGTGTCATGCAATTGATGCCAT AGGCATGGCTAGAGAATAGGTGCTAAGG

CTTACTTTCAATAAAATATGGCAGTTCTTT ACAAGGGGCCGATGCAGAGTGATGGGC

GGAGTATCTACAATAAAGATCAGAAAACT TCAGAGCATGCTAGGCTTTGGAAGCCAG

TTTCTGTAGAAGTTCAGATAGTAAATATTT GCAAAGACGTTGATTCCAAGGCAGGAGC

TAGGCTTTGTGGGCCGTATGGTCTCTGT TCTTCACTTGAGGACCATAGA

TGTAATGACTCAAATTTGCTCTCGTAATG

TTAAGGAAGCCATAGACAATACGGAAAT

CTTAAATGAGTGTGGCTGTGTTCAATAAA

GCTA I I I l I GGACACTGGCTTTTGAATTT

CACATAA I I I I I I I I I I I I I I I GAGATGAA

GACTCACACTGTCGCCTGGGCTGATGTG

CGGTGGGGCAATCTCGGCTCGCTGCAG

CCTCCATCTCCTGGGTTCAAGTGATTCTT

CTGCCTCAGCCTCCCGAGTGGCTGGGA

CTACAGGCGCATGCCACCACACCCGGCT

AA I I I I I GTA I I I I I AGTAGAGACGAAGTT C

TCACTATGTTGGCCAGGTTGGTCTCGAA ⁴^

CTCCTGACCTCGTGATCTGCCCACCTCG

GCCTCCCAAAGTGCTGGGATTACAGGTG

TGAGCCACCGTGCCTGGCCGAATTTCAC

ATAA I I I I IATATGTCATAAAATATTATTAT

TTTTA I I I I I I I I I GTCGATGATTCAAAAA

TATAAAAACTATTCTTAGTTCACAGGCTA

TACAAAAACAGCCTGGATTTGGCCCACTT

TGCCTGGACCATAATAATGTCTATTGGGA

GATAGCCAAGAATTGCTTTTCATCGATGT

GTGTGCTTTATGCTTCTATGACTACCTGG

ACAGTTTCCAGAACACTTTCAAGCCTTAC

Supplementary Table 3

SNP Chr Position 5' Ranking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1544909 1 55153061 GGTATTGGCACTTGGTACACATTCAATAG C/T GTTGACATCCTAGATGTATCACAACCCG SEQ_0029

ATGC I I I I I I I I I I I I I I I I I I I I I GAGACA GCTCAGAAGTCATCTCTTTGAAGCCTCCT

GAGTTGTGCTCTTGTTGCCCAGGCTGGA TTTTGGTCTAACTAAAAACCCTGGGGCAT

ATGCAATGGCACGATCTCAGCTCACCGC TTTTAGTGACCCCCAAAAGGGGCATTCA

AACCTCCGCCACCTGGGTTCAAGCGATT GAGACACACTCTTGTCACCATCTGGCTTT

CTCCTGCCTCAGCCTCCCGAGCAGCTGA CTTCCAAATTCTTTGTGAACACACCATCT

GATTACAGGCATGTGCCACCACGCTCGG TTCCATGTGTCCTGCTTTCTGCATCCAG

CTACTTTGGTA I I I I I AGTAGAGACAGAG

TTTCTCCATGTTGGTCAGGCTGGTCTCTA

ACTCCCAACCTCAGGTGATCCGCCCGCC

TCGGCCTCCCAAAGTGCTTGGATTACAG

GCGTGAGCCACTGCACCAGGCCCAATAG

ATGCTTTTATTCTGCTAATAATCCTTTACA

GTCTGGCTTATACAAAAGGTTAAAATTAT

GTCCGTTGTCAACATAAGGATGATAGAAA

CTTTGGTAATCAGTGTTTTGCCTTGAACA

GATGTTCTTTCCTTACTCCCAGTCCCTGC

CCTTTCTCTGCC

W

Ul

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs696620 1 95029485 AGGCGGAACAATAAATGAGGCAAAAAAA CfJ TATAGATGGCAGTTCCTTATGGAAGGCA SEQ_0030

AAAAAAAATCAGAGAGAGGATACCATCT GTCCAGCTGGTCAGGATAATTCCCCAAG

GAGTTACTATCAGAAACTTACATGCTCCC GGAAGCAGGCCTAATTTGGAGGGGTTCT

ATATTGGTCCATTTGTTTCCCCTTCTTCT ACTTTCCAGCACATTCTGTGCACTTGGCC

GCCCAACTGTTTTATAAATTCCCCCTTCA TTGTCCGGCAAACTGGCCCAAGAGTCCT

ACCTTCAAGAGCTTCCTTCCCATCCTCAC GCCAGCCCCAGCCTGCTGACATTCATCC

TCTCAGCCCATGATCTTACCTCCTGTTTC TGCCTGTGTCTCCCACTGGCTTCAGCTT

ACTGAGAAAACTGATGCAATCAGAAAAC CGG

CTCTGCTAGTGCTGACCACCTCACACCT

AACCTGCTATCAACACGGGTCCATAATCT

GAGTCCTCTCCCAGAACATGATATTAATA

AATGGCCCATGATCCTATGGCCACACTT

CACCAGATCCCATTCTTTCTAACCTGTGT

GAACATAACTCTTCAATAATTTTCACCCT

CTTCATCAAAATCTTTCTCTCTATTGAATC

ATTCGCAACTATCTCCCATCTTTAAGAAA

AATCTACTGTGGACTCTTTCCTCTTCCAG

CTTCCTCTCCATTTCTGTTCCTTTTAACA

GTGAAATTCCTCAAGATTGTCTATACTTA

CTCTTTCCAATTCTTTTCCTCCCACTTTCT C

CTTCACCTACTCCAATCATGATTATTCAG °"

TGGTCAATCCTCAGTTCTTCCTTTAGCGG

CAGCACTTGCCACACTGGACCGCGCACA

TCTCTGTGAAACCCTTCACCTGCATTCCA

GGGCCCCACACTCCACCCCTTCTCCTTC

GACCCACTGGTCACTCCCTTTCAGTCTTC

TCTGTTTGTTCTCCCTCATCTCCCGGGCA

TCCTGAAGTGCCTCAAAGCACAGTCCTT

GGATTTCTTCCCTTCTCTATCTACATTCAT

TCTAATCTCATGGTTTTAAATACTATTAAT

ATGTTCCCAAGTTCCTAAATGTGAATCCC

AGCCAGGACCTCCTCCACTAACTTCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS859104 1 95033047 GCTTTGTGGCTGCATATGATTTCTAGATC C/G AAACAGAATGCCTGTTAGGTAGATGAGG SEQ_0031

TΠTCCCACTATGGATΠTAAAACAACTA TCAGTGGACTCTGAGAACCACTCTGGAA CTACTGGGAAGAAGATGCATGCTCTGGT TATGAGAAGTGCTCTGAGCCAGGGAAGA CTTTGGTGAAACCTATAGCTTGAAGAACA AGTACCTGCTCCTCCTACAAGGCCCAGC TTTAGAGATTGTTTCATATTTCCTGCCATA AGTATCAGCGACAGATTATGCTTTTGCAA GCTATAAATTGACTTTAGGCTCGTCATTC AACTAGGTTTACAATATCACGAATAGTTT AGGAGTCCTTAGATATTCACAGTAGGGT GCGGGCGGAGAACATTTCCACAGAACAG CTGTGTGAAGGAAAGGGGAGGATATCCG GAAGGATGATTTCTTCAGACAGACAAAG TGCTGTAGATCAAAAACTGATTCCACTGA GTAAGTATGTCCTACAGGACCTGGACGC CTAAGGCTGATCTTAATTCCCAAGCTCTA TAATGGGGGCCAGACTCTCCTCTCAGCT TGTTCTGCTGAACAAGAATTACATTGTAA GCCCTGTGCTGTCAAGTGCACATATACG GAAACAGTGGAGCAGCTTGATTTATAGA CACACCTCCCAACCTGGCACAGTCAGCG GAGGTTAATGTTTTATGAATGCTGGGCTC GTGGGAGCAGCTGAAGTGATGAGTCAAG ACTTTGGCTTGGAGGCAATCTCTGTTTTG ATCCGCTTAGACATTATTTGGCATTCCCC GGTAAGGCATGGATAAATGCCTATGGTT CAAAGAATGGCATTTGGCACTCCCCAAA TTCTAAGATGGGGTGATTCAGGGCATGC GAAGCAGAACCTGCAAGTTATTTTTGAGT TTCAGGAAACATTCCCAATTCCAGAGGA GATCACTATTGTTTCTGAACATCCTTATC GGTGGCCCCTCC AAAGCCATCTTCTATTTGT rs859101 95036805 GTACAGAGACTTGCCCCCAGCCTCAGCT A/C TTTGATTTTGTTATTCTAAGATAACACAAA SEQ_0032 GTACCTGATACCCCAAGTCCAGGCCCTC ATTACTGTCAGGCAAATATTACCTGCTGG TCTGCTTTCCCTCTCTGGAGAACAAATTT CAAATTTGGTTAGAATACTCTCTTTGCTC TCCTGTCTTCAGCTGGTGTGGAATTTGG CCCTACCTGGGAGGAAGCAATACACACA GGGTCTAACTACTCCTGAGGAAGGCTTT ACCCACCCCCGGCTGCTTGGAGGTTCTC CAGCTAATCTTTGGAAATAC I I I TTATACT AATGCCAAGGGCAACAGCCCCTCTGTGA TGAATTCCTGAGCCTCTCTGGGATTCTGT GTCCTCTGGAGTCTCTAATGATGGAGGC GGCTCACTTCAGGCTGCATCTTATTTGTC TCCGGAACTGCACCACTACATTAAAAACC CTCCTCATGCAGCCAACACACACGGACA CACAGTGGTGGCCGGGTGTCGTGGCTC GGCTGCTTCTGCTTTCTCCAGCGGGCTT ATCCTGTAATTCCCAGCACTTTGGGAGG AGGGCACTGCTCCACCTCCCTCTCTTTTT ACTAGGCGGGTGGATCACAAGGTCA GGCTCTCACCATTTGGTTGGTGTTTCTTA TCTGCTGTCATTGCCTCTCTGTTTCTTAC TGTCCTGGTGTGTTTGTGCCTGTTTCAAT CTTTCATGA I I I I I I GAGTGGCTGGAGAA AGGGAAGAGATTAGGAGATAAATGCATA TGCTTCACTGGAAGTCCAAATTAGAAGTC CTCATTGAAAATG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs6600673 1 120780890 TATAAGTACACATGTGTGTGGATAATCAA A/G CACATGAAGTGTTTTATACATATTTTATTT

TCTTACATTCATGGCAATAATAAAAAATTT A I I I I I IAAATTAA I I I I I CAAATTTATTTT

CATAAAAGTGGTAGCCTCAGAAGTTGAA TTAGACAGGGTCTTGCAGAGCCCTGGGT

GAAAGCATGATGCTATTAAAGAGTTATAA GGAGCACAATGATGCAATCATAGCTCCT

TCGGCTTTAGCTGTTTTCAGATTGATTTC TGCAGCATCGAACTCCTGAGCTCAAGCA

I I I I I AAGCTGGATAATTAGCATACAGAT ATTCTCCCACCTCAGCCTCCCAACTAACT

I I I I I I ATCCTAC I I I I I CTTTTGGA GGGACTACAGGCATGCTCCACCATGAGT

GTCTAA I I I I I I H I I I I I I I I TGGTAGAG CCTGGGTCTCACTCTGTTGACCAGGCTG GTGTCAAAACTCCACTCCTGGTCTAAAGT GATCTTCCCACCTCAGCCTCCCAAAGTG CTTGGATTACAAGTGTGAGCCACTTAGCT GGGCTGATAACATATTTTAATAATAGATT TTAAATATATTGACTAAA I I I I I GTAGCTT CACAAGTATTTGTGTGGTTTGAACATTAG TAAACAGTGTATTATCTTATGCATAAAAA CCTTCATTAGTAGTTCTTCCTTTCAAGTTT GGGAATTACTTGAATTAAATATGGAAGCT CCATATTTAATTACCAATGAGTCAGTAAT GTT C

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6600662 1 120842832 ATACTCAGTCTTTGAAACAAAAGCAGATA CFT AAAAACAAAGAAACAAAACCAATTACTTT SEQ_0034

TTCCCCCAACATAGTACACCTTCCACTCA TGGTTTCTTCCCTGAGTTTTCATTAGCTA TTTCCAATGCAAACATTCCCATTCCCAGC AATTCACATCACAGAAAGAAAGACTAAAG ATCCCCCAGAAAAGGATGTCTCCTGTCT TCTTTAAACACATCTGGACAGACTTTTGT CTAACTTGTACAGGTGCATTCTAAGATCC CACAAAACATΠTCTGTTCTGTGGGCCCA TGGGAGAGAAGTTAGTAATATGTTTATTT GTAGACTTTGTCCCAGGCCATTATATGTT CCCATATGCTTTTGTAAAATTTGCTGAAA CTTTGCGCCCATTAAATTCCCCTCAAAAT TAAACTACTTTAACTGAAATTGTTTAATAC . TATTTTCTACCTCTTTAAAATCATCCACGC TACTATTTATTTCTACTACAAA I I I I I CATT TTCTCCATCTCACTCTCCTCTTTAAAAAAA GCACTTAGTCACATGTCAGATGGTGTGC AAAAAAGAGATAGAAACTTCTATACCCCA TAAGAAGAAGTTAAGGGTACATTTGTTAG TTTAAATATTGATCAATCAGTCTATAATTC GGA I I I I I I ATAATATAGTTTGTGTTTTGC TTCCCTGTATGTGCTAATAAATTATATGC AGTCACTTCTGTGTAGAGACAGGTTATTG CATTTTCCTAGTAATCTGGCTTTTATAAAT CTAACCACCACAGTGTAGAAATAGCTTCA TAA I I I I I IAGCAAAAATTCAAAGGGCAA AGGCATACAGAACTTCTGCTGTGTAACTC ATGGAAAGTTTTCGCTTCACTTCTACACA ACCCAGCACTGGGATTGAGTATTCCAAC ACTATCCAACCTGCTAGAACCTATCTGGC ATGAAGGTGCAGTGTCACAAACCAGGTC TTCAGTTTCTTACTTGGATGCATAACACA CTGATATCCTGGTGTCACTTGCCACCAG GACCCTCATTCCAGAGGAGCCAGAGCTC AAGTAAGTACGGAGTGCAGGAGATACCA CTGGCCACTGTGCCCTTCTCAGTCCCTT GGTTACAAATGTATGGAGCCAGGAGCTG TACTGTGTGTGGGTCATTCGAGTGCCAA GTTTGTCAAAAATTCTTCCAATCATCAGA CCTTGCCAACATGCTGACTCCTTTTCTTT CCAGTTAAATTTAAGGGAAAGTTTCAATT TTTCCATTCCTTGGTGATGATGAGGAC CTCATCCACATTTAGACAGAACCGAAGTT TGTCCTATCAGGGATATATTTCACAATAC AACATAAACAATTACAAATGGACCGTAGG TTA I I I I I I CTTTTATGATGGTAATTGTGT GAAATAGAATGCTTCAGAAATGGAAGGTT AGTGGGAAGAACTAGAGCACCTGCCACA CTGCAGCTGGTCTTGGCAGCATACTCAA CACTTACAGTCTTC I I I I I ATTCTGTTGG GGCTCAGAAACCAATACCCTAGAATATG GCACTTTGACATGCTGAACTGAAAAAGAA rs 11249433 1 120892655 AAACACTAGATGTGTATTTGGAAAAACCT C/T TTTGGAGTTCCTTGGTTGCTTCTCCTTAG SEQJD035

AACTATTGATTTAATAATAGTTTGTGATGT CACAGTGACTCATTTGATATCATCTTTAA TTTAAATTCTAATTATACAATTTTAATATTG TTTCTCTGGCTAAAGGTTTTCCAACAGAT TTCCTAAAACAGATTAATGACTCTTAGGA ATACAAATTCTCTTCTTGACCTAGAGTTA ATTTAAAAGACTAAGATTACTTTGGAAAC TGTAATGGATGTACCAGCAGGAATTAATG ATGGAATCCAAAACTGTGAAAGAAAAAG AAAACATAAGAGTATCTGCAAATCAAAAT CAGAGAAAGCAGGGCTGGGTTTAA TGATTCTCCCTΠTCTCAGGTATCCG

ΓS3790793 1 196853863 TATAAGTAACATGCAAAACACCAGCCAG A/G TGTAATTAAGATTGGCAATGCATGAATTA SEQ_0036

GAAAGTAGCAAAAGGAATAAACGAAAGC TTTTCACTGTTTTAATTGTCAGGGACACT AAGA GG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 33'' FFllaannkkiinngg SSeeqquueennccee rs12071085 1 196855087 CTTTCACCACATTATTTCCAGAAGTATCT C/T TTAAGGAACCTTTTCCCCTTAACCTTTTAACCTTGGAATTAAGGCCTTGGGGGGCCTT TTCCTTCCACAGGGGTTCCCTGTCTGCT CACACTTGACATCCTCTCTTAACTGCCTC CTTGCTTCCTCCAGCTCCTCAATATATGT TAGACCAAAACATGCAAAGTCTTGCAGT ACCTTTCAGGGTTGTTTCAGCAGTCCTGA GTGGGAGGGAACCTGTGGCTGTGCATTG AGTTGTGTGTGTGTGTAAGCATGATTAAG GGTTCAGTTGATAACAATAATCACCAGCC AGTACTTTTGTGGGAGTGTGCTATTGCCA CTGATGAGTCACCAGAGAGCAATGGGGT GCCTCACAGATGGTGTTATTTCCTGTG GATACTCAAGTACCAGAGAGATGGTGGT G rs16846147 196859199 CCAGACCTGCCAAAGGTGTTGGCGGGA AJG ATTACAATTCACAATTAGCCTGCATTTTAT SEQ_0038 GTGAGATAAAGTAGATGCAAGGGGTTTA AAAATACCTCTAAAACATCTTCAACATTTA ATAAAAATTCAAAGAATGACATAAATATAA AAAATTGGATGTTAAAATTGGTGATACAT AGTATTATTCTCAGA TAATAATACTC rs3790791 196860915 AGCATTTTAAAGAAATCCTCTTCGTGTAA C/T TCCCTGCAGAAGGCAGGCTAGAGCCCAT SEQ_0039 ACTATTCATGATACTCCATGGACACAGTG TGTTTTCTATCCCCTAGGTCTTAGAGGGT CAGTTGGGATTGCTTGTAGCAGCTTCCT AGCAAGCGATACCAGCTCACGCAGAAAA GTTTCTAGGCTTTG GGGACATGGATGACA rs 16846165 196863308 GTGGGGTGAAATAAAACGGGATAGATAA A/T ACTAGAGGACATAATTGGATTCACATTTA SEQ_0040 ACAGGCCAGATAAATGTGTTTAATCTTTA AAGTTATCACTCATGCTGTTGTGAGGAAA ACCCAGGGTAGTGGGGTGCCATTGAATG ATGCATTTGGAGGCGGGGACAATATTGG ATTTTAAGCAGAGGG AGGAATCAGTTATA rs 10494809 196863741 AGAAAGCCAGACAGATTGAGCTACATTTT C/T AGAACCAAATAAAGTTATATGCTGCAGTC SEQ_0041 AGACACTGAGTTTGAGATGTCCCCTGGC TTCCACATGGGTCACTGAGTGAGCTGGT TATCAGGTAGAGACATCTAGTAAATAGTA GAAAGCATTGAACACACTGAAATAAAATG AACAGTCATATGTA ^■ TTCAACACATGGAA rs12131233 196866832 TATTGTCTCCATAGTTTTGTCTTTTCCAGA A/T AAGTGGACTCATAAGCGTTTCC I I I I I GT SEQ_0042 ATGTCACACAGTTGGAATCATACAATATA GACTGGCTTATTTCACTTAGCATAATGTC GAGCCTTTTCAAAGTGGCTTCTTTCATTT TTCAGTGTGACAGAGACCAGAGTAGCCC AATAATACACATTTACGTTTCCTCCATGT ACCATTCCCTTTGAACATTGGTATTGTAC CTTTTCATGGGCCAACAGCTCGTTTCATT CACAAAATCAAGTGGTTTTCAAACATTTT TTAGTGTTGTGCAATATTTCATGGTCTGG TGATCCGTGGGAGC I I I I I I I CTAAACCA ATACACCACAGTCTAACCATTCACATACT TGTATACAAAAAAAGTCAAAAGTGGAGAA

AAAGGACATΠTGGTTACTTTCAAGTTTG ATTCTTATTTCTTAGCCTTGGCACCTGTA

GGCAATTATGAATAAAGCTGCTATAAACA CAATACAATTGGAAGGGGTTGGGGTGGG

TCCCTATGCATGTTTTTGTGCAGACATAC GCT

ATTTTCTTCATAACCATTTAAACGTATACA

GTTCAGTAGTGTTAAGTTCATTTGCATTG

TTATACAACCAATATCCAAAATTCTTATCT

GACAAACTGAAACTCTATACCCATCAAAC

AACAACCTCTGTTCCTCATTCCTGCCAAC

CACCATTCTATTTTCTGTGCCTAACAAAT

TCATTTGACACAGGTGCCTCTAGGTGCC

TCTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12069085 1 196867725 CATTCGCATATCATGAGACCCTTTAGAAA A/G ACTTTGAGATCCTGGGAAAGCCATTTAAT SEQ_0043

CGGAACTACTTGACTAACCAGCACTTCC CCCTCTGATTCTTAATTTCATCATACCTAT CATTCTCCAACTCCAGCAAGTGACAGAA AACACCTTCTAGGATAGAATCCTTTACAA ACTTGCAGGCATTGACACAATAGGGGAA TTTAGCTTATCCTGAATCCCACTCCTAGG AAAAAACTCCAGGACTTTAAAATAATGAG CCAGnTTCTACATACTCTCACTAACTCC CCCTGCAGGGTTCAGATTCCTGCTCCGC TGGGATTTCACCCATCACCCATCAGCTG CCGAGGGAAGTCTCATGGTAGAGCATAC TACACTGATAAGTCCCAAATCTATACCTC AAGGACTTTAGAGTGAGACAGGCCTGGT CAGCCCAAGCCTTTCTCTTGAGGTCTAG

CATAAATTCAAGATCTTCTTACTAGCATTA ACCTTTATGTCTGGCCATTTCCTGGACAT AAATCCTAGATGAGCTTCTCAACCCCTTT CTTCACCCAATATTCCATGTGCCCCTTAA AAGCCTCTGTΠTTCCACTGGGAAAATGA ATTCAACATGGCCATACCTAGACTCCTTA TATTAATAATAACTTCCCCATAAGATTCTT AATATTGCTTCTCAAATCTGCTGCTCCTC

AAGAGGATTAAATGAGAAAACATATGTTA TTGGTGACAGCCACCACCTTCTTCCCTTA AAGACACTTGTCACATTAATTGGTGTTTG ACAGACACCTGGAAGCCATCCAGGACCC GTAAATGTTATTTCCTCCCTCATTCTTACT TCACTCTTTCTCTCTGTCTCTCCTA I I I I I TATTAACCCAAGGCCAGCAAACCCTGTT GCATCAACCATCTTGATGCCTTTCAAGTC CCTCCCCAC rs 10494810 1 196868239 CTCTCTGTCTCTCCTA I I I I I I ATTAACCC A/G TATTTCTCATCTGTGTTCCTGCAGCAGGA SEQ_0044

AAGGCCAGCAAACCCTGTTGCATCAACC TCCTGGCTGGTCTCCCTCCATGAGCCTG ATCTTGATGCCTTTCAAGTCCCTCCCCAC CTCTCCCCTCACCCTCCTGCACACACTA CTCCTTGGCCGCC GTCCCTTCTACACAC rs6541240 1 227397313 AAATATCTGCCTACAAGAGATACTGATCT A/G GAGTGCTGAATTTACTGCCAATTACCTAA SEQ_0045

TTTTCTAAGGCCATCATTCATTTTCAAATC TAAGAACAAAAACAGGGACTCAAATGTAT CCAAATAATCTTTGTGATGTCTCCTAGCT TAACATAATGCTTAACTGTGGATAATACA ATCACAAAAGCTAGTAATAAGCCTAAATA AACCACTATAACGCAATGACAGTCTTTTT ATGTCCACATAACATGGCAATGTGATTTT CCTACTTCTTCCATTCAAAATATAGTCAA TTACTGTGAATGTTATGAGAAATACCCAA AACGCTACTCAAAATATACACTAAAGATG ATAGCATCACAAATCTCAATTCCTG AACCACTTTGTATCACGTTGTTTAGG rs2543037 233827463 GAATCTATAAATTGGTATGTACATAAGAC A/C CCGGAACCATCCACATCCTAATCCCTGG SEQ_0046 AGACTGAAATTCCTATTGATCGGTTTGCA CACCTGTGACGATGTGACATGGTAGGTC AGAAAATCAGGCTCCTGTCAAATCAAAAA ACTGCTGGCTTTGAGGGTGGAGGATGG GTAGACTTTTCAGTCA I I I I I CAACTAGA GTCACAAGCCAAGAATGCAGGCTAGAAA TTGTTCTGACTTCCATTTGATCTTGTCAAT AGGCAAGGAAACAGATTTTTCCCTAGAG AACATCTTACTCGAGCTCAGCACATCCAT TCCCTGGAAGCAATGCAGTGCTGCCAAC GATAGGGTAGCCCACATAATGGCAC ACCCTGATTTTAGCCAATGGAGATTGATT TTAGACTTGTGACCTCTAACGCTAGAAAA . TAATAAATGTATGTTGTTTTAAGCCACCA ACTTAGCGGTAACTTGTAAAGGCGGCCA TAGAGCAACTATAGCTAGGGGCTTCAGG TAATTGAAGGTTTTATTATTGTGGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs12048201 1 233827899 AAGGTTTTCTGAGTTTCCAGTAGTTAATC G/T ACAAAATAGTGAGTGTGGTATTAI I I I I C SEQ_0047

ACATGATTTAGAATTTAAATTTAAGTATAT TTTGTTAATAGCAGCCTGTTCAGTCTTTG TTTCATATTGCATGCATAGTAGACACTAA GCTATAGTCTCTTCTGTGTCAGGTAACAG TTACTTTTAACAATAACATTAATCAAAAAT TATTTGAAGTATGGTCACAGTTCCAACAG AACTAAAAAAATGAGGATATATATAAATG TAGATCTTCATATTTCTTTTACATCCTCAT CAATTTGTTGAGTTCCTATCGTATTCCAG TCTTCTGGTATTATGGTATCTGCTCAGAG ACAGGCATCTTCCTAAGCCATGAA GCACTACATCGTAAAGCC I I I I I I G rs16835155 1 233829030 TCATCTTTTACCACCTAATTATATATGGTT C/G AGATTTCTGTAGTTCTCTTTGCCCTGTTC SEQ_0048

TTTAAAAAATCAGGACACAAAATGTCCAG TGTGTTTGCTTGGTTCACAGGCTAGCTTC AGGAAGAGAAGATTCAGATTTAGTTGATC CCTCATGATTACAGGATACCTTGTAGGAA CAAGCTCTAGGT TTTCAGGGATGAT rs 10925373 1 233830690 TTTATTTGATTAGTCTCATTCAATTTGGAC AfT TTTTTCTTTTTTGAGATAGAGTCTCATTCT SEQ_0049

ATCTTCCTCAGCTATTTGTGTGTGTTTAT GTCACCCAGGCTGGAGTGCAATGGTGCA AATAGAAAAAATTTTCATTTGTAAACATAT ATATCCTCCCCAAAAAACAAACACAAAAG GATAGCAAATAAATGACATGGCATATTTC CAAAAACAACAATTAACACTCCTTCCTGC TGATTCAATCTTAATAAACTATTCTGCAAT A I I I I I r I GGTGTGTTTTCTTCAAAGCACT TTATGAGTGACTTAAAGATATGTGGAACC GAACACCTTCTGAAGACTATGTATTCGCG TATTGAGTCAGCCATTCTCAAAC GTCTGTTTATTGCCTTCCTATCCCCATTA GAGTGTAAATCTCAGGAATGCAGGTCTTT GGGTCTGTGGTATTCGCTTGCTATACCA CTAACATCCAAGACAATGCATGTTATGT rs2787102 233830749 ACATAACATGCATTGTCTTGGATGTTAGT C/T TGCACCATTGCACTCCAGCCTGGGTGAC SEQ_0050 GGTATAGCAAGCGAATACCACAGACCCA AGAATGAGACTCTATCTCAAAAAAGAAAA AAGACCTGCATTCCTGAGATTTACACTCT ATGTTTGAGAATGGCTGACTCAATAGGTT AATGGGGATAGGAAGGCAATAAACAGAC CCACATATCTTTAAGTCACTCATAAATTG CGCGAATACATAGTCTTCAGAAGGTGTT CAGAATAGTTTATTAAGATTGAATCAGAA CAGTGCTTTGAAGAAAACACACCAAAAAA ATATGCCATGTCATTTATTTGCTATCATAT ATGCAGGAAGGAGTGTTAATTGTTGTTTT GTTTACAAATGAAAA I I I l I I CTATTATAA TGCTTTTGTGTTTG I I I I I ! GGGGAGGAT ACACACACAAATAGCTGAGGAAGATGTC A CAAATTGAATGAGACTAATCAAATAA rs 10925374 233830800 AATTTGGACATCTTCCTCAGCTATTTGTG C/T TCCTGCA I I I I I I I GGTGTGTTTTCTTCAA SEQ 0051 TGTGTTTATAATAGAAAAAATTTTCATTTG AGCACTGAACACCTTCTGAAGACTATGTA TAAACATATGATAGCAAATAAATGACATG TTCGCGGTCTGTTTATTGCCTTCCTATCC GCATATTTCTGATTCAATCTTAATAAACTA CCATTAGAGTGTAAATCTCAGGAATGCA TTCTGCAATTTATGAGTGACTTAAAGATA GGTCTTTGGGTCTGTGGTATTCGCTTGC TGTGGAACCTATTGAGTCAGCCATTCTCA TATACCACTAACATCCAAGACAATGCATG AACATTTTTC I I I I I I GAGATAGAGTCTCA TTATGTACTAGGTAGTAAGGAAATATT TTCTGTCACCCAGGCTGGAGTGCAATGG TGCAATATCCTCCCCAAAAAACAAACACA AAAGCAAAAACAACAATTAACACTCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2787109 1 233833199 CTGAGGTAAGGAGTTCGAGACCAGCCTG A/G TGAGAAGTAAACTCTGTCTCAAAAAAAAA SEQ_0052

GCCAACATGGAGAAACCCCATCTGTACT AAAAAAACAAAAAACCTCTTATGGGGAAA AAAAATACACAAAAATTAGCCAGGCGTG CTACATACAAATCAACAAAACTTAAATAT GTGGTGGGTGCCTGCAATCCCAGCTACT CTGTATCATTAGTACCATCCACATCAAAT TGGGAGGCTGAGGCAGGAGAATCGCTTT CCATGCTGGAGCTTTAGAGCCTGTACCT AAACCAGGAGGCAGAGGTTGCAGTGAG CAAGAATCAATAAATGATATAATTAATTTC CCAAGACCATGCCATAGCACTCCAGCCT CTTACATGTCATATAATTGTCATTCA GAGCA rs9428665 1 233834571 CTGGGTGTTCACATTTTCTTA I I I I I GTCT A>G AATAACTTGCTGAGATTTTGATTGGGATG SEQ_0053

CTCATTTTATATAGTGATTATTTGGTATGT CACTGACTTGTTAGAATGTGTAAAAATTT ATTTTATACATTTTATTTACATTAGAATAT TTCTGTATTCCTCTGTGTACCTGCCAGTT GGTTTTGTTCAATGTCCATTCTTTAACCA TTTCATAGTATATAGATCTAAAATGTAAGA ACACCACATTGTCTTGATTACTAGTAGCT CTTTATTATATGAAATTTATTATTCATAATA TTATAGTAAGTC I I I I I IATTTATTTATTTA GATCTAAGCCCAGGAGGTCAAGGCTGAA I I I I I I GAGACAGAGTCTCGCTCTGTCAC GTGAGTGCTACTATATTCCAGCCT TGGGCTGGAGTGCAGTGGCACCATCTTG GTTCACTGCAACCAACCTCTGCCTCCCG GATTCAAGCAGTTCTCCTGCCTCAGCCT CCTGAGTAGCTGGGACTACAGGTGCGCA CCACCACACCCAGCTAA I I I I I GTATTTT TAGTAGAGACGGGGTTTCACCTTGTTGG CCAGGATGGAATCCATCTCCCGACCTCG TGATCCGCCCACTTCGGACTCCCAAAGT GCTGGGATTACATGTGTGAGCCACTGCG CCCAGCCTGTAGTAAGTTTTGAAGTTACA TAATGTCTGTCTCTGACTTTGTTCTTCTC CAATGTTGTGATTATTGTGGGTCTTTTGC CTTCCCATATAAATTTTAAAATCAGTTTGT AAAAATCTACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9428376 1 233834603 CTGGGTGTTCACATTTTCTTA I I I I I GTCT A/C TGACTTGTTAGAATGTGTAAAAA I I I I I CT SEQ_0054

CTCATTTTATATAGTGATTATTTGGTATGT GTATTCCTCTGTGTACCTGCCAG I I I I I C

ATTTTATACATTTTATTTACATTAGAATAT ATAGTATATAGATCTAAAATGTAAGACTTT

GGTTTTGTTCAATGTCCATTCTTTAACCA ATTATATGAAATTTATTATTCATAATAGAT

ACACCACATTGTCTTGATTACTAGTAGCT CTAAGCCCAGGAGGTCAAGGCTGAAGTG

TTATAGTAAGTC I I I I I I ATTTATTTATTTA AGTGCTACTATATTCCAGCCTGGGTGAA

I I I I I I GAGACAGAGTCTCGCTCTGTCAC AGAGAGAGACTCTGCCAAAAAATAA

TGGGCTGGAGTGCAGTGGCACCATCTTG

GTTCACTGCAACCAACCTCTGCCTCCCG

GATTCAAGCAGTTCTCCTGCCTCAGCCT

CCTGAGTAGCTGGGACTACAGGTGCGCA

CCACCACACCCAGCTAA I I I I I GTATTTT

TAGTAGAGACGGGGTTTCACCTTGTTGG

CCAGGATGGAATCCATCTCCCGACCTCG

TGATCCGCCCACTTCGGACTCCCAAAGT

GCTGGGATTACATGTGTGAGCCACTGCG

CCCAGCCTGTAGTAAGTTTTGAAGTTACA

TAATGTCTGTCTCTGACTTTGTTCTTCTC

CAATGTTGTGATTATTGTGGGTCTTTTGC

CTTCCCATATAAATTTTAAAATCAGTTTGT £

AAAAATCTACAAAATAACTTGCTGAGATT *-

TTGATTGGGATGCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs9428666 1 233834620 TTTTCTTA I I I I I GTCTCTCATTTTATATAG G/T TAAAAATTTTTCTGTATTCCTCTGTGTACC

TGATTATTTGGTATGTATTTTATACATTTT TGCCAG I I I I I CATAGTATATAGATCTAA ATTTACATTAGAATATGGTTTTGTTCAATG AATGTAAGACTTTATTATATGAAATTTATT TCCATTCTTTAACCAACACCACATTGTCT ATTCATAATAGATCTAAGCCCAGGAGGTC TGATTACTAGTAGCTTTATAGTAAGTCTTT AAGGCTGAAGTGAGTGCTACTATATTCCA TTTATTTATTTATTTA I I I I I I GAGACAGA GCCTGGGTGAAAGAGAGAGACTCTGCCA GTCTCGCTCTGTCACTGGGCTGGAGTGC AAAAATAAAAAATAAAAAATAAAAA AGTGGCACCATCTTGGTTCACTGCAACC AACCTCTGCCTCCCGGATTCAAGCAGTT CTCCTGCCTCAGCCTCCTGAGTAGCTGG GACTACAGGTGCGCACCACCACACCCAG CTAAI I I I I GTA I I I I I AGTAGAGACGGG GTTTCACCTTGTTGGCCAGGATGGAATC CATCTCCCGACCTCGTGATCCGCCCACT TCGGACTCCCAAAGTGCTGGGATTACAT GTGTGAGCCACTGCGCCCAGCCTGTAGT AAGTTTTGAAGTTACATAATGTCTGTCTC TGACTTTGTTCTTCTCCAATGTTGTGATT ATTGTGGGTCTTTTGCCTTCCCATATAAA TTTTAAAATCAGTTTGTAAAAATCTACAAA ATAACTTGCTGAGATTTTGATTGGGATGC ACTGACTTGTTAGAATGT rs2808227 233834651 GTAGTAAGTTTTGAAGTTACATAATGTCT C/T GCCAGTTTTTCATAGTATATAGATCTAAA SEQ_0056 GTCTCTGACTTTGTTCTTCTCCAATGTTG ATGTAAGACTTTATTATATGAAATTTATTA TGATTATTGTGGGTCTTTTGCCTTCCCAT TTCATAATAGATCTAAGCCCAGGAGGTCA ATAAATTTTAAAATCAGTTTGTAAAAATCT AGGCTGAAGTGAGTGCTACTATATTCCA ACAAAATAACTTGCTGAGATTTTGATTGG GCCTGGGTGAAAGAGAGAGACTCTGCCA GATGCACTGACTTGTTAGAATGTGTAAAA AAAAATAAAAAATAAAAAATAAAAAATAAA

ATTΠTCTGTATTCCTCTGTGTACC AAAAAATATATATATGTACTATGTAC rs2808228 233834663 GAAGTTACATAATGTCTGTCTCTGACTTT A/C TAGTATATAGATCTAAAATGTAAGACTTTA SEQ_0057 GTTCTTCTCCAATGTTGTGATTATTGTGG TTATATGAAATTTATTATTCATAATAGATC GTCTTTTGCCTTCCCATATAAATTTTAAAA TAAGCCCAGGAGGTCAAGGCTGAAGTGA TCAGTTTGTAAAAATCTACAAAATAACTT GTGCTACTATATTCCAGCCTGGGTGAAA GCTGAGATTTTGATTGGGATGCACTGAC GAGAGAGACTCTGCCAAAAAATAAAAAAT TTGTTAGAATGTGTAAAAATTTTTCTGTAT AAAAAATAAAAAATAAAAAAAAATATATAT TCCTCTGTGTACCTGCCAGTTTTTC ATGTACTATGTACATATCCTGAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs2050657 1 233835117 GCCACCGCACCCAGCCTGGATATGCACT G/T TATTAGACATAATAATAGACTTTGTTAGAA SEQ

AACTCAAAATTATCAATATCTCCTTTCTCT AATATTCAGCTTAGAGTACCACCTCTAGG AAGTACAGAATACGTTAAAGTGGCTGTTG AATGTGTATTAGTTTAAATGTATGATTAAA CATAAACCTTAATGTTAACAAATTCAAGT AAGTCATCACAATAAATATAAGGAAAGAA GGATGGATGGGTGCTAAGTAAATAATAC ATCATCAGTCATGAATAATGATGGAACTT AGTAAGTCTCTTCCATGGAGGCTACTTAT TTGCTTAGCTAAAATTAATAGAAAAAAAT CAGAATTACTAAGTTAAATTAAATACCAC CAAGTTGATTACTACTCTTAAATAAATTCC AAGTAATTTCATTTGGGAGATAAATAGTC AGCTCATGTAATACTGTTTCAGTGTTTTC AAGAAGAATAAGAACAATTTGGGGGTCA TGAATTTGTTCAAATCCTCAGGATATGTA GGGGAAAAGAATGAGGGGGACTAATCTT CATAGTACATATATATAT TTTTTTA AATATTAAACATTTCTAAAATACAGTGATA I I I I I I I IA I I I I I IA I I I I I I GGCAGAGT AATGTG CTCTCTCTTTCGCCCAGGCTGGAATATA GTAGCACTCACTTCAGCCT rs12023820 1 233837494 TTATACCACTTTTCCCTTTGGGGCATTTG A/G CG I I I I I ATTATTATTATTACGAGACAGG SEQ_0059

CTGAGTATTCATTTGGGCAGAGATTAAG GTCTCATTGTCCAGGCTGGATTCGAACT GCAGAGGAGCCTGCAAAGTTTATGTAAT CCTGGGCTCAAGCAATCCTCTCTCAAGT CTCTGGCCTGACAACGTAGGCAGAATTT AGCTTGGATAACTGGCATGCACCACTATT GAGGATACAAGATCTTGAAGGAAAAAGA CCAGATCA I I I I I CTGTTATTAGCCTTTG GAAATAAGGCTTACACTCTGAAGAGGCT GGAAACAAGCTCAGAAGCTTAGCAGAAA TTCCCCTTGAGGTATTTCTCTGTTGGTGG GCAGATCAAAAGCTCAGCAGTATAGTAA 4- TG GATGTGACTATCGATTCTATGAAACAATA CTAATAATGTCTCATGAGGCCTAATCTTG TGCTGGGGGGCCAAAAATTGTATTTCAG TGGTTGCTAAGGAGGAGGGGTTT rs7551196 233857434 TCCTCCTTCTTACACACCTTGTGATTATA A/G AGGTAGTCTTTAATCAGAGTTTTAAAAAG SEQ_0060 TACCATGACCCCTTTATACATACTCCTTA TAGAGGGAGAAAAAAATCTGAGTATAAAT

CTCAGCCTGAAGTGAGCTTCCCCATATC .GGGGCTGTGCAATTCAAACCTGTGTCGT

CAGTTTTTCATTTGACAGTTGTTTACTGA TAAAGAGTCACATGTACATAAAATATGTA

GTACTTACCATGGCCTGACCTCACGCTC AAAGTTTCATTCCATTCTTATAAAAACTTT

ATAGCTGGAGGTGAAATGATAATCAGGA ATTAAATTATAACATCAATACATATTTATT

CAGCGTCATTGTCCTTCAGGAGTTTTCAG CTATACAGTTTGGAAGTTACAGAAG

TCTGATCAAGGGGAGGAGGGTTCTTGTG

TAGAGTGTAAGGCCAATGTACATGTGTAT ACCTAGGGCTGCAGGAGGATGGGGAGA GTGAGTAGCTTTGAGGAAACTGGATGAG GCTTCATAGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4290053 1 233859977 AGAGAAATAAGGTATCTTTATTGAAAGAT A/T AAMATATGCAAAAGTTTCATTCCATTTTT

CAGATTTAAGAAMTCTACCTGTGAGCTC I I I I I I I I I I I I GAGACGGAGTCTGGTTC

CAATATTAATTGTACTCACCAACTTCTTTT TGTTGCCCAGGCTGGAGTGCAGTGGCG

TCTTCTTCACCAGGTTTCTCTTTTACCAC CGATCTCGGCTCACTGCMGCTCCGCCT

ATCTGCTCCTCCTTTCACCCAGTTATTCA CCCAGGTTCACGCCATTCTCCTGCCTCA

CTAGGCTTCTCTTGGGCACAGTΠTCTTA GCCTCCTGAGTAGCTGGGACTACAGGTG

TTCTTTGCCTCATGTATATATGCACATATA CCCGCCACCACACCCAGCTAATTTTTTGT TATGTGTATATATGTAAATGTTTTAAATAT A I I I I IAATAGAGACAGGGTTTCACCGTG ATATTTTATAAATACTTTAATGTATTCTTA TTAGCCAGGATGGTCTCGATCTCCTGAC GCTATTACATATACAGCTGACCCTTGAAC CTGGTGATCCGCCTGCCTCGGCCTTCCG AACACAGGAGTTAGGGGTGCCAATCTCC GAGTGCTGGGATTACAGGCATGAGCCAC TTCACAGTAGGAAGTCACATATAACTTTT CGCGCCCGGCCTCATTCCATTCTTATAA GATTCCCTCAAAAGATAACTATTAATATC GAGCTTTATTAAATTATAAMGCMTACAT CCCCTGTTGACCAGAAGCCTTACCAATA ATTCTATACGATTTGGMGTTGCAGAAGA CCAGTCAACACATAI I I I I IGTATGTATTA AMATTCTGATCACACTMTAGGAAAAAA TATACTGTATTATAATAAAGTAAGCTAGA CTGTTGGAGGCTTTTAAAAAMGTTTTAA GAAAAAATATTAAGAATATCGAAAGAAAA TCTCTTCTGTCCTTMGGC I I I I I I I I I I I AAATATTTTCTACACATAAAGTGGAAATG MACATMTTG GATCATCATAAAGATTTTCATTCTCATTGT CTTCGTGTCAAATAGGCTAAGGAGGAGG 4- AAGAGGAGGAACTGGTTTTGCTGTCTCA GGAATGGTAGAGGGGGAAGAACATCTTA GTAAGTGGGCCCGTGCAGTTGAAACCTG TGTTGTTCAAGGGTCAACTGTATATAAM TATGT rs12073854 1 233861758 GGGATAGCATTAGGAGATATACCTMTGT G/T GCTGMGCCA I I I I I I AAATCAAATTAAC SEQ_0062

GAATGACMGTTAATGGGTGCAGCACAC TAAMTAAGAATATGTTTTATCTACCATTG CMCATGGCACATGGCACATGTATACGT CTMCTAACATTGTTCTGGAAATTTTGGC ATGTAACAAACCTGCACATTGGGCACAT TGACATGTCAAGATATAAMCAACATAAA GTACCCTAGMCTTAMGTATMTAAAAA ACAGTTTCATAAAGTGGTTGGATGTAAGA ATAAAMTMAAMTACCACTATCCMCA AMATATGTAAAAACMTTTGTATAGAGC AGGGCACACAAATTTTCMTCTCAATCAT AATCACATATTAAMTTTAATGAAAACAAT GGATATTTATGTGATAATTTGATTTTAATT TCCACATTCTACAGCAATCAMACACATG GTCTATTTAATGAAATTCAAAAGTATAGG AACTGCATGAGCTAATAAATGTGAGGGTT ATGAGMGTATAGGMATACATGGACGT TCTTTTAAGACMCTACTCTCTATA GATTTTAATGATGATTTAATMTATCATTT CTTTTAATGTGTTACATCACATGAATAGG TCAGATMGMAACTTGTGATCATGTTAG CAAGTGCTGGAAAAGG I I I I I AATAAAAT TCAATGCTCATTCTTAATGAAAACTAAAC ATTGATTAATTCCTCAGTGATAMGATTAT CAGTGTCAGATCMTAGTGMTATTGTM TTGTGMA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs6670163 1 233862625 TCTGGGAAGTCTGATTATTGCAAAGTTGT G/T CTTTGTAGTTAAGAGTCAGAATCAGAATC

TACCTTTTTAAAAAATAAAGGCAGATGTT TGCAGGTCAATTTGATTTCACATCCCCAT AAGCACAATTTATATTTAAAGTCTATAAAC GGCACTGAATTCCACCTAACATACCAGC ATAGGGGATTATCGTGGGCTACCTGTCT ATATCTGCCACCGATTGGTTCATCTGCCT TGAGGTCAGACTGACATTTCTGCTGTGG TCTCACACTCACAGACACACACCTAGCT CTAAAAACAAGTTTAGGGACCCTGGGAG GGATGGGCCCTGTACCATAATAAGACAT CCTCTTGGCTATAACCTTGGGAGCCATT TTCTAGCCTTTGCATTA I I I I I CCAGTGA rs 10925391 233866656 CCTTCCCTAAGTGTCACACCCAGTTTCTA A/C TCTGCAGGGGAGGCTTGTTGGTGGACCA SEQ_0064 GGAGAAGAATCTTATTTTATCCTAAGCTA TACACCCTGCCTCTAAGCAGCGATCAGA AGGCTTAATTCTTTCTCTTTTCATGGTGT ^■ AGGAGAAAAAGTACGAGTTGGAGATGAC AAGAGATTAATTTGCATTAATTCCGGATT CTCATCTTAGTTAGCGTGTCCTCTGAAAG TCTGAAAGTTGTGTGTTGGGAATCATTGG GTACTTGGTAAGTGTGGAAAGTAGGATC CAAAGAAAATAGATTTTAATTAAGAGGAA ATGTATCTGCTGATATGCTAAATGACAAG C I I I I I CATGTTTCACATATCCGTAT TCAATAAAATGATCTCTTTAAGGTTTATAT rs 10925394 233871139 GGGGTACACTAATACAACTATTACAATGC A/G AAATGGTTGTAAACGCCTCACCCAGATAA SEQ_0065 TAAATTGATGAAAGCTGGTTGAGAGGGT TGTCTTTTCTCA I I I I I GCTGTTTTATGTT TGGTTTTCACCCTGTCCTCTGAGAACATG CTGAGGTAAAAGGATATGTTAATCTTCTT CCTTGTGGACAGAAGAGGATACTGTGGA TTCAAAAATATCCAAAAGGAAAGAATTTT

4- CAGCACCTGGGATTGCTGCACCGTTGTC TTTTGCTCATTGAAAATCTTATTTTCTTTT 00 TGCTTTATATGTTGAACATTGGGGCTCAA AAAGAAGGCCTTAGCAAAGCACCTTAAG TTCTGAGGTATAAAGGGTCTTAAGCTCTA AGAAATATACAATTTAAAATAGAAA rs 11693502 136642681 ATGCATAGAGATGGGGTCAGGCCCCCCC CfT AAACACCCTTTTCCTGTCTACTTCTCAGT SEQ_0066 TGCTTTTAGCTTTGGTTTTGTCACCAACT ATAGAATAGAGGCTGGTAAATGACATATG AACTTTTGGGTCCAGCAAACAGTGGGTG ACTTCTCTCAGCCTGTCTTGCAATTAGGT CCCAACACATGTGAAATGTGAGTTTTAAA GGCTCATGTGACCTAAGGGGCTGTTTGC AATTCTCTTGGCCTCGATTTTCTTTGTTG TGGAGGGTTTCTGGGAAGAGTTATTTTC TCAAATAAGACAGTTTTCCACTGTGGCAG CTAAATAAAGTGATAGAGACATGGGAAAA GTACTGTTGATTAACTCTATAGTCATTT CAGCCTGTTCCCTGCCTTCACCTTCCTG CCTTGAAAGCMCTGTGGGGGAAAGATG CTTGGAACTGGGATGACCACTTTATCTTG TGTAAACACATGTGAGGATGAAAAGTCAA CTCTCTGAGGATGGGGAGCCTTGAGACA GCAAGAGCCTGGGCCCTTGAGCACCATT GCTGGGCCATTGCACCAATCTCAGAATT GCTTACCCATGCCCTTCTTATTACATGAA GTGATTCCATGTCTCTAGCTCTTAAACAG AGTCAGGTTTTCTCTTTCTTGCAGCCAAA GTCACATCTTAAGTGATTGTAACCACTAC AAAGTGATACTCTC

Supplementary Table 3

SNP Chr Position 5'^' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11678022 2 136642765 GCCCAACACATGTGAAATGTGAGTTTTAA NT GGTGGCTCATGTGACCTAAGGGGCTGTT SEQ_0067

AAATTCTCTTGGCCTCGATTTTCTTTGTT TGCTGGAGGGTTTCTGGGAAGAGTTATT GTCAAATAAGACAGTTTTCCACTGTGGCA TTCCTAAATAAAGTGATAGAGACATGGGA GGTACTGTTGATTAACTCTATAGTCATTT AAACAGCCTGTTCCCTGCCTTCACCTTCC CAAACACCCTTTTCCTGTCTACTTCTCAG TGCCTTGAAAGCAACTGTGGGGGAAAGA TATAGAATAGAGGCTGGTAAATGACATAT TGCTTGGAACTGGGATGACCACTTTATCT GACTTCTCTCAGCCTGTCTTGCAATT TGTGTAAACACATGTGAGGATGAAAAGT CAACTCTCTGAGGATGGGGAGCCTTGAG ACAGCAAGAGCCTGGGCCCTTGAGCACC ATTGCTGGGCCATTGCACCAATCTCAGA ATTGCTTACCCATGCCCTTCTTATTACAT GAAGTGATTCCATGTCTCTAGCTCTTAAA CAGAGTCAGGTTTTCTCTTTCTTGCAGCC

AAAGTCACATCTTAAGTGATTGTAACCAC TACAAAGTGATACTCTCTAAAGTCACTTT GTTCTAAGACTCTCACAGTATGTACTGAA CCAA I I I I I I I I CCTGGTATTATATCATTA TAGGTGAGTTTCA rs11681248 136653808 CTTCATAAATTACCCAGCCTCAGGTATTT CFJ GCACAGTGTTCCCTTTGTATTTGTAAAAC SEQ_0068 CTTTATAGGAATGCGAGAATGGACTAATA ACTTCTTTCACCTAGCCTTTGGGACCTCT CACCACCTTAATTACCCACCCACCTTCAC CTGAATCTCCTCCTACCTCACTCAGTCTT CTGCATCCATTTTCCCTGTCTTCCTTCTG GTTTGCTGGAGCCTCTGAACCCTAGATG TAACTGTGGATGAACCGACTGTGTCCTG ACAGTAGGCCCCACACTCAGCCTTGGCC TCTAAGGCCAACCCCTCTTTCCTACAGG CTTTTCATCTCCATAGATACTCACTCGCA CTAGGCCTTTTTCTCTTTCCCACATCATT AGATGATCTCATTCAGTGCCATGACTTCA A I I I I I I CCCTCTCTACTGGATCATTCCC . AATGCCATTTATAGACTGAATATTCCCTA ATCAGCCTGTAAATCAAAACAAAACAAGG ATTTATAGCTCCCTCTCTTCCAGACTCCA CCTTCCTTGACCCCATGTCCCCTTGCAG AAGCTAGAAATCCATTGCCTGCTTGTCAT CTATATCCTCAGTTTGCTCCTTC I I I I i AT CTCCACTTGGATACGGAATAAGCATCTCA AGCAGAACATTCAAAAGAGATATATTTCC AAGGAATATTTATAAAAACAAACTGCATT TCCTTGACTCCATTTCCTTTCCTCCCATT TCGCTGCCTTCATCCTTCAGTCCAAGCCT CTCACTCTTTAATC I I I I I AAACTAGGCTT CTACCTTCTCTTGCCTGGACAACTAGAAT CATCTACACCACTCTTCTAAAACAGCTCC TGCCCATTAATGGTΠTCCCTGCTTCCAC TTCAAGGTCACCAATGAGTTCTGTATTGC TTTTGCTCCTCTACAGTGGATTCTCTGTA TAAATGCAGTGATCAACTCTCAGTCCTAT TAGCAATCAGATTAATCC I I I I I ATGTATT CTGATGCC TACTTTCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs932206 2 136659004 TTTG I I I I I CTTAAATAGCTGCATTATTCG A/G CTGAGTCTAGCTTCAAAGGCATCTTGAAT SEQ_0069

TCTGATGTTGAAAATGGCATCTGCACTGT AAGTCGTAAGCTCAAAGAACCATGCCCC

ATGTAATTTCCATACTCGCTTGGCACCAT AAAGCACTACATACCAGTGGGGGCTGTG

CAACTGCCTTTGATGACACTCAGGACTG TCAGACCAGGAGGCGAAGAGAATCTCAA

CATC I I I I I I GTCTCCTCCTTCCCTCCAG GCCATAAGGGGCCCTTGTGGTGTCTAAT

CTGCAAGACCCAGATGTCAGGTTCAGGG TA I I I I I I I I I CCTTTCCCAGCCACTGTG

ATGCATTTTCTCTGGCAGGGATATCTGG CTGGGCCGAGCAGTCGTGCAGGGCAGA

CTCCTCTCGGCAGTCCCTAAGTTGGTGG GTTTGGAAGCTTCCCACGATCAACTCCG

CTATTGTGGAACCGCCAGCAAAATAGCA TCTCCTGAGTGCCCACCCAGCCGCCCCA

GAAGATCACGCTAAAGATGGGATTCAGA CACTTACTGCCTCTAAAATCCCAACAGTT

TGGCTTTTTGAAAACGAAAAACAGAGTCC CAAAGGAGTTCGCTGAAACTCAGTCAGT

GAATCTGGGAAGAAAAACATATTTCTTAT GAGAGCCTGTCTCCCAGGCCAAAATCCA

GTCTCTAATTATAAGCCAGGAAAGTGGC GGTTATCCAGTGCTTTTAGAAGTATGAAG

AGGCCGTGCCTGAGAAAATTGCACCACC TGTTGCATCTTAATGGAATTTAGTGCCCA

CCCCGGCCCCCCTGCCACCATTTATCTG TGAATTCACCCATCCACGGTATGCACCG

CTGCTCATCCATTTTCCCCTCTTGACAGT TTTTGTATGCCGCCCTGACATTTCACTGC

I I I I I ATCTCCCCACTCTGCATCTGAAAT ATGGCCCTTGTGAATCTAGATTATATCTC

CAGCAGCTGGGTATGATGAAGGGTTTGC TGTCTTAGTCTGTTTGGGCTGCTGTAACA

CTAAGTTAATCAAACCTGGGGTAGTGAC AAATGCCACAGATCAGGTAGCTTATAAAA

AGGATCAGGCCTGATGTAAAATATGTGG AACAGAAATTCCTATCTCACTGTTCCAGA CΛ

ACAGGGAAAAGAAAAAAGAAAGGAAGGA GGCTGGGAGGTCCAAGATCAAGGTGCT °

AGGATAGAAGGAAGGGAGGGAGGAAGG GGCAGATTTGGTGTCTGGTGAGGGCCCA

AAGCCAGCCTAAAGGAATTGGCCAGGTG CTTCCTGGCTCATAGACAGTAACCTCACT

TAACAAAGATAAAGAACAGAAGACTACCC CCAACCTCACATGGTAGAAAGGGTGATG

AGTACCTCTATGCCCGAGGAGGCAATTT AGGGGTCTCTCTCAGGCCTCTTTTATAAG

GTAGCAGCATTCAGGTCACCTGGGCATT GGCACTAGTCCCATTCATAAGGGCTCTG

GATACATCACAATTAGCTTTCC I I I I I GA TCCCCTTGATCTATTTGCCTCCCAAAGGT

AGCAGCCTTTGTAAATATGAATGGAGATC CCCACCTCCTAATACCATCACTTTTTAGG

AAGCGCCAACCTGCCCACATCCCGGCCT GGTGAGGATTTCAAGATACGAATTTGAAA

GGCTTAC GAGCCATAAACATTTAGATTAAAGCAGCC

TCTGTTTAAGGGAGGTCCACTCCAATGTA GACTGATTCTTTTGCTTCCCTCCACGGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1532552 3 1437739 GGGGGTCTTCCAGTCAGGATTTGCCTAC C/T TACATACAGGAAGATAGCAGACCAGAAA SEQ_0070

CCACGCAAAGTGCAAAAGAQAAATAAAG TTCAGATCAGGTCGAGTCAACTACAAAAC CATTTAACCAGAAAATTAAGACCCAACCA CCATGTTCTGGAACCACTAAGGTATGGA AGTCACAAGAAGTTGATTGTAGCAAAAG CTCTTCCTGTTCTGCATATCTTCCTTGTG CAATGTACATTGG I I I I I I CTAATAACTGT TTCCTCCAGATCGATTCTCCACCCTTCTC TGACACATAAATCTTTAATTGCTAATAATG TGCCCCTC I I I I I GTCCTAGGAGGATGAT TATTGCTTATGCACTCTGCTATACCATAT CTGCATGGATTA I I I I I ATAAGTTCCATTT ATATATATACATATATACATACATAATCTC TCTCTGGCTTCTTGTTAAATGTGACCAAT ATTTATGCCTCACAATAATGCTCCMGGA AGAGGTCACTGGCAGGGTTGGAGGGGG AGGCATTTCTTATACTGGTTTTACAAATG TTCCTTTAACTGACTCTATTCTACCATCAT AGAAGCTGAAGCTGAGAGTGAAGATACG TGCTTTTCTCAATGCAGCTAATTCTATGT GTTTGCCCAAGTTA AATTTTCTCGCTCATAGTTCTGGTAACCA

CTTTCTTCTCTΠTCCCTTTGAACCAAGG

GTTGTGTGTTAGATTGCTCACAGAGATAG

CTGCAATTATTATTTTCATTGTTGTATAAA

TATTCTTTTGTAATGAGACTTTGTTTCTTC

TCCAATATAGGAGTGGAGTCTATTTCCCC

ATCCCATTAATTAGTGGTGTTCTTATCCC

TTGCTTTAACCAAGAGAATGTGACAAAAG

TGACATTTTCCATACGTAAGTTCCAGAAC

CATGGCCTCAGGAGGCCTTACAATTTCT

GCCTΠTCC I I I I I GAAACTTTAAGATCAT

CGTATAAGGAATCCCAGTTACACTCGAG

TATGAATGACCACAAGATGGGACTGCCC

CAGCTAACAGTAAAAACAAAACTTCAGTG

ATGTGAATGAGGCTACCTGGGACCTTTC

AACCCATTCAATCTGCCAGATCACTGCAC

TTACATGTACAATCTCAGGCCAGGCTAG

CAGGAGGGCTGCCCAGATGATCCTAGCC

TAAATAACTAAATCACAGAATTGTGAGCA

AATAAATGTTTTAAAACACTAAGATTGGG

AGGTGAGGTTGTTATGCAATAGATGACT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2167468 3 1438537 TAGAGAAACACGTCTATGGATTCAGGAG A/C TGAGATTGTACATGTAAGTG CAGTGATCT SEQ_0071

CATGGGGAGATGGATCCTATGGTAATCC GGCAGATTGAATGGGTTGAAAGGTCCCA

I I I I I CAAATAAGTCTTCGATTAATTATCA GGTAGCCTCATTCACATCACTGAAGTTTT

GACTGTCATGGTGGAGGTATCAGCCAGG GTTTTTACTGTTAGCTGGGGCAGTCCCAT

GTCCAGGTGGTAGACATGAAATCAGATA CTTGTGGTCATTCATACTCGAGTGTAACT

ATTTGAGGGGGATTTATGAACAAAATGAA GGGATTCCTTATACGATGATCTTAAAGTT

CTTATGGAAGCATAAGACAGTTGAACAAC TCAAAAAGGAAAAGGCAGAAATTGTAAG

TGTATCAGTCATCTATTGCATAACAACCT GCCTCCTGAGGCCATGGTTCTGGAACTT

CACCTCCCAATCTTAGTGTTTTAAAACAT ACGTATGGAAAATGTCACTTTTGTCACAT

TTATTTGCTCACAATTCTGTGATTTAGTTA TCTCTTGGTTAAAGCAAGGGATAAGAACA

TTTAGGCTAGGATCATCTGGGCAGCCCT CCACTAATTAATGGGATGGGGAAATAGA

CCTGCTAGCCTGGC CTCCACTCCTATATTGGAGAAGAAACAAA

GTCTCATTACAAAAGAATATTTATACAAC AATGAAAATAATAATTGCAGCTATCTCTG TGAGCAATCTAACACACAACCCTTGGTTC AAAGGGAAAAGAGAAGAAAGTGGTTACC AGAACTATGAGCGAGAAAATTACATAGAA TTAGCTGCATTG rs9873658 3 1438666 TGTATAAATATTCTTTTGTAATGAGACTTT A/C AGTTGTTCAACTGTCTTATGCTTCCATAA SEQ_0072 ^

GTTTCTTCTCCAATATAGGAGTGGAGTCT GTTCATTTTGTTCATAAATCCCCCTCAAA tJ

ATTTCCCCATCCCATTAATTAGTGGTGTT TTATCTGATTTCATGTCTACCACCTGGAC

CTTATCCCTTGCTTTAACCAAGAGAATGT CCTGGCTGATACCTCCACCATGACAGTC

GACAAAAGTGACATTTTCCATACGTAAGT TGATAATTAATCGAAGACTTATTTGAAAA

TCCAGAACCATGGCCTCAGGAGGCCTTA AGGATTACCATAGGATCCATCTCCCCAT

CAATTTCTGCCTTTTCC I I I i I GAAACTTT GCTCCTGAATCCATAGACGTGTTTCTCTA

AAGATCATCGTATAAGGAATCCCAGTTAC ACTCGAGTATGAATGACCACAAGATGGG ACTGCCCCAGCTAACAGTAAAAACAAAA CTTCAGTGATGTGAATGAGGCTACCTGG GACCTTTCAACCCATTCAATCTGCCAGAT CACTGCACTTACATGTACAATCTCAGGCC AGGCTAGCAGGAGGGCTGCCCAGATGA

TCCTAGCCTAAATAACTAAATCACAGAAT

TGTGAGCAAATAAATGTTTTAAAACACTA

AGATTGGGAGGTGAGGTTGTTATGCAAT

AGATGACTGATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9835151 3 1438857 I I I I I GAAACTTTAAGATCATCGTATAAG A/G TGTTTCTCTAGGAAATCTTAATTAATAGTT SEQ 0073

GAATCCCAGTTACACTCGAGTATGAATGA ATATATAATAGTTACTTGGTGTCTGGTGT CCACAAGATGGGACTGCCCCAGCTAACA GTTGCTTACATTATCACTGCAAAACTGGA GTAAAAACAAAACTTCAGTGATGTGAATG ATTAAGTATTATTATCATCCTATTTTACTT AGGCTACCTGGGACCTTTCAACCCATTC ACAAAAAAGCAGAAATTTGGAGATAAAAT AATCTGCCAGATCACTGCACTTACATGTA ACTTAATTAGGTGCAGTGCTAGTAAGTAC CAATCTCAGGCCAGGCTAGCAGGAGGG CAGGCTCTGAGTTCAAACCTAGATCTTCA CTGCCCAGATGATCCTAGCCTAAATAACT CTTTACTCCAACACTTATGTTCTTTCCACT AAATCACAGAATTGTGAGCAAATAAATGT TCGTCAAACTGCCTCAGAAATTGAAATTT TTTAAAACACTAAGATTGGGAGGTGAGG TAGTTCTAACAGCTAACCAACCATAGACC TTGTTATGCAATAGATGACTGATACAGTT TCGAGCACAAACTCTGTCAACTTAGGAAT GTTCAACTGTCTTATGCTTCCATAAGTTC CTCTGGATGTCCATTCCATAAAAGGTGTT ATTTTGTTCATAAATCCCCCTCAAATTATC TTGAAGCTGTAATTTCTTCTCTCAGGG TGATTTCATGTCTACCACCTGGACCCTG GCTGATACCTCCACCATGACAGTCTGAT AATTAATCGAAGACTTATTTGAAAAAGGA TTACCATAGGATCCATCTCCCCATGCTCC TGAATCCATAGAC rs 1382862 1441413 TGTAGGTTGGAAAGAACAATGTTTAAAAA C/T AGAAGTTTATAGAGTTACATGAACTTCCT SEQ_0074 TACCCTGTCTCCTCCCTGAGAGGTATGA CAATGTCTTGCAGCTAGTGTGAAGGAGT TACCATGATTCTCTCTCTTTATCTAAAGG CAGGACTCACACCATAGCACCCATATTC TATTAGTCTAAGGAATTAAAAGCCA I I I I I CAGAACCCACAGCTAACCACTGGATTCT CTATGAGAAGAAAAATGAACAAGATATGG ATGCCTATGAGGATACATAATACTTACTG GAAGGTGAACTAGCAGAGCAACATATAG TTTCAAATAACTTTATAATAGTTTTCAGTT AAATAATAATAAAAGGCCTTATTCAGAAT AAAATCTTGTCTCTAGGCTTTTGGGCAAA GTAAAATACACTATACTAAAAGGTTTACC GAACTTTAAAAACTCTGAGCCTCCATTCC TTGATTATAGCACTCAATCATTCCAAGAC TCCAGCTTAAAAATGGAGACAGTAGGTA TCTGAGATTGTAGCTATTATCATATCCAT ACTCTTACCACTGAGACAACGTATGTAAA ATCTTA ACACATACACACGCATGCACATATATATA CCCCCAAAATACTGGTGTTCTGATTCCCA TTTTACAGATGTAGAAACAGGGACTCAAA GTTGTCAATGTGTTCAACGTTTTATAAAA GCAGATGAAAGAGTCAAGACTCAAACCT AAATCTATCTGACTGCAAAAGGTGTGGC ATTACCTGGGCAGCCCATTGAGGAAGTG CTCGGAGCTCATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2167471 3 1444092 TATGTAAACTAAGTATTCAAGTGGACTAA A/G TATTCATTTTGATGTTTGGTGATATGTTTG SEQ_0075

AGTACTGGTAAATAAACCCAACGGAAAA TGATCAGAAATATGCCATAAGAACTTACC

CATTGGGCCTCCGAAACATACCAGACAC I I I I I IATATCAATTAACCTATGATAAAAC

ACAGCTGTATGTTCTGCTTTATTATTTTAG TGGTTTCATTATAGGTCATTTCACTTAAA

GTA I I I I IACCTGCCTAAGCTACTTATCA GTTTCAGTTTCCAAGAATATGTCAACAAT

GAGACTATTATCTGCATTTTCCAGTTCAG GTTAAGTGAGGACTTGCTGTATATGTTTT

GAAATTGATTTTATTCTATTTATGATAAGC TCCAGAGGTCATATAGCTGGTAAGTAGC

AGGTCCTCAAATAACTTTGTTTCTTTCAAT TGACCTGGGGTTGGAACATATGCCTCCT

GTTATTTCCTTATAACGTTGATGATGAAA CAATTTCAGGGATTTTCCTGCTTTTAAAC

AAATTGATTCCCGCCAGGGCCACTGTGT AATTGCTTCTTTCTTGGTATTCACAGAGG

TTATGGAATTTGCATGCTCTCCTCATGTC TAAAAAATATCACAAAGTATCAAAGTACC

TATGTGGGTTTTATCAGGACCCTCATGTC ATGATGATTATATTAGGTAATGTTTGAATT

TCCCCCTACAACCCCAAAATGCATATGTT AATGTTTAAAACAATAC

CAGTTCATTGCTGTGTCCAAATGGTCCCA

GTCTGAGTGAGTGCGGGTGTGTGTGAGT

GTACCCTCCAATGGGATGGCATGCTGTC

CAGGGTCCTGTTCAGGGTTGGTTCCCAT

CTGGTTCCCTGAGCTGCTGTGATAGGCT

ATGACCACCCGAGACCATGAACTGTTAT

GAATAAGTGGGTAAATAATGACCTTACTG S

ATTAATTAATTATTAACTGAGACAGAGTC ⁴^

TTGCTCTGTTGCCCAGGCTAGAGTGCAG

TGGCATGATCATAGCTCACTGCTGTCTTG

ACCTCCTGGGCTTAAGCAATTCTTCTGCC

TTGGATTCCTGAGTAGCTGGGACTATAG

GTGCACACCACCATGCCTGGGTAATTTG

I I I I I IA I 1 1 I I Ai I I I I GCAGAGAAGTGG

ACTATTAGGTTGTCCAGGCTGATTTCGAA

CTCCTGGCCTCAAGTGATCCTCCTGCCT

TGGCCTCCCAAAGTGCTGGGATTACAGG

CATAGGCCATCATGCCTGGCCTTTAATCT

TTCTTAAATATATGTGTAGCTCACATTTAT

Supplementary Table 3

SNP Chr Position 5' Ranking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9854037 3 1444844 GAATCCAAGGCAGAAGAATTGCTTAAGC AH^" CATAAATAGAATAAAATCAATTTCCTGAA SEQ 0076

CCAGGAGGTCAAGACAGCAGTGAGCTAT CTGGAAAATGCAGATAATAGTCTCTGATA GATCATGCCACTGCACTCTAGCCTGGGC AGTAGCTTAGGCAGGTAAAAATACCTAAA AACAGAGCAAGACTCTGTCTCAGTTAATA ATAATAAAGCAGAACATACAGCTGTGTGT ATTAATTAATCAGTAAGGTCATTATTTACC CTGGTATGTTTCGGAGGCCCAATGTTTTC CACTTATTCATAACAGTTCATGGTCTCGG CGTTGGGTTTATTTACCAGTACTTTAGTC GTGGTCATAGCCTATCACAGCAGCTCAG CACTTGAATACTTAGTTTACATAATCCTG GGAACCAGATGGGAACCAACCCTGAACA AAAATACAATTGAGAATTTTATTCTCTGCT GGACCCTGGACAGCATGCCATCCCATTG TAATTACCAGGGTTGAT GAGGGTACACTCACACACACCCGCACTC ACTCAGACTGGGACCATTTGGACACAGC AATGAACTGAACATATGCATTTTGGGGTT GTAGGGGGAGACATGAGGGTCCTGATAA AACCCACATAGACATGAGGAGAGCATGC AAATTCCATAAACACAGTGGCCCTGGCG GGAATCAA I I I I I I CATCATCAACGTTATA AGGAAATAACATTGAAAGAAACAAAGTTA TTTGAGGACCTGCTTA rs9848527 1446181 TGATGACATTTTAGCAGGGA I I I I I I I GT G/T AACTGATGAACCAAAATGCCACAACCTTG SEQ_0077 Ul GTTTGGAATA I I I I CTTTGTTG I I I I I I I I AGAAGAAATTAACTCAGAGTTATTCATCT Ul TTCTTACTTTCATAACTAATTTCCCTTGAA TCGAAATCCATGTTTTAGGTGGTTTCCAT AGGGTATGACTTGGATCTGACTTGTTCTG GGTGACTCCCTGGCTAGCAGCATCTTTG AATTTTACGCTACAATAAAACATGTTAGG TCTACCAGATGTCTTATTGTTCAACAGCT GAGAAACTTCTGTGTCTCTGACAGCCTG CATCTGTCTTCAGAGTTTAAGGTTTGAAA TCCTCTAAAACACATCTCAACATGT ACTGAAGTCCAAGCAGAACACTTTCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7616977 3 1449968 GAATGATGACACTTGTTTTCCCTGAAAGT GfT TATGTGAACATTTCCCACCTCATTTGATA SEQ_0078

TGGGTCTTGAGCAAAGTGACACACAATT AGGTCATTATATCAGATATTAAAGGGGAG

AAAAATCTGGATGGAGAGTTATTTTGGGT AGAAATACATATACTTTCTGCTATATATAA

TTTGAGACTGCCAAAGACTTCCTGCAATG AAATAAATC I I I I I I I ATATATAGTGTTGA

AAGATCTGCACTCTGAACTTCTGAGCTG TAAACAGATATAAATATATGTACTATAATA

CTTTGGTTCCCATCTTTCCTGTGGCTGG TAGATATAAAAGAAAAAACTACATACCAA

GTCCCTCCCTCTCTCTG I I I I I CCTGTGA TATCACTCATGAACATAGATACAAA M i l l

GCACAGATGACTACATTGGTGAATTCAAT TTAATTATAAGCACGTAGTATCTACAGAC

CAAACATTTAAAGAAGACATAATACCAGT ATATATATCATAAATATATCTATGGAATAT

TGTAACTGTATTCGGACAACAGAGT ATGGAATAATGCACTATAACCAAACAAAA

AATGCAAGATTGAATATTTTAAATTCAGT CAATGTAATCACCCCATTAACAAAAAAAA GAGAGAAAAACCATATTATTTGAATAGAT GCTAAAAAAACATTTGATAAAATTCAACA CATATTTATATTTGTGAGGCTAAGGAATG TCCTTGGATGCTAATCCACCATGTTGATT TCTGATTAACCTCTGTTCTGGGAATGCTT TTCAGCTTTCTACTTTATGTACTATTACCG TAAATCCTATGCTTCTGTCAAAGCAACCT

TGACCATAAGACCACAAGTCCTTCCCTCA tn

GGCAGATTCACATAACTTTCTTGCCTTTT °^

CTTGGGGAGTTGACTTCAGTTGCCCTGC ACGTTTCTTGTCTATGATATATAAGCCCT GGATCTTGGTGGTAAGCACATGGATCCA TGAACTGGTCTCTCGGCTGCCCTAGACT ATTGCTTCTGCTTGTAAATCTGTATTCAA GGTTTCTGAGAAACTGGGAATGTCGGGC TCTTTCTTTGTCCCCAAAGCTTCCTTGGC CTTTTGGGGGAAGGTTTGCATATGCTTG CTCACCATAGAACAATACTAAGTAAAAAT GTTCAGCAAACAAAAAAATAGAACATCTT TAAGATATAGTGCATCTACCAATATCTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7627169 3 1450324 ATCTGGATGGAGAGTTATTTTGGGTTTTG C/G AGAAAAACCATATTATTTGAATAGATGCT SEQ_0079

AGACTGCCAAAGACTTCCTGCAATGAAG AAAAAAACATTTGATAAAATTCAACACATA

ATCTGCACTCTGAACTTCTGAGCTGCTTT TTTATATTTGTGAGGCTAAGGAATGTCCT

GGTTCCCATCTTTCCTGTGGCTGGGTCC TGGATGCTAATCCACCATGTTGATTTCTG

CTCCCTCTCTCTG I I I I I CCTGTGAGCAC ATTAACCTCTGTTCTGGGAATGCTTTTCA

AGATGACTACATTGGTGAATTCAATCAAA GCTTTCTACTTTATGTACTATTACCGTAAA

CATTTAAAGAAGACATAATACCAGTTGTA TCCTATGCTTCTGTCAAAGCAACCTTGAC

ACTGTATTCGGACAACAGAGTTTATGTGA CATAAGACCACAAGTCCTTCCCTCAGGC

ACATTTCCCACCTCATTTGATAAGGTCAT AGATTCACATAACTTTCTTGCCTΠTCTTG

TATATCAGATATTAAAGGGGAGAGAAATA GGGAGTTGACTTCAGTTGCCCTGCACGT

CATATACTTTCTGCTATATATAAAAATAAA TTCTTGTCTATGATATATAAGCCCTGGAT

TC I I I I I I I ATATATAGTGTTGATAAACAG CTTGGTGGTAAGCACATGGATCCATGAA

ATATAAATATATGTACTATAATATAGATAT CTGGTCTCTCGGCTGCCCTAGACTATTG

AAAAGAAAAAACTACATACCAATATCACT ^' CTTCTGCTTGTAAATCTGTATTCAAGGTT

CATGAACATAGATACAAA I I I I I I IAATTA TCTGAGAAACTGGGAATGTCGGGCTCTT

TAAGCACGTAGTATCTACAGACATATATA TCTTTGTCCCCAAAGCTTCCTTGGCCTTT

TCATAAATATATCTATGGAATATATGGAAT TGGGGGAAGGTTTGCATATGCTTGCTCA

AATGCACTATAACCAAACAAAAAATGCAA CCATAGAACAATACTAAGTAAAAATGTTC

GATTGAATATTTTAAATTCAGTCAATGTAA AGCAAACAAAAAAATAGAACATCTTTAAG

TCACCCCATTAACAAAAAAAAGA ATATAGTGCATCTACCAATATCTTAAAGC S

CAACATCATACTTGATTCCGAGAATTCAA -¹

ATGCTTTTCTAAAAGGATCGGGAACAACA CAAAGGCGTTTTCTCAAACAATTTCTATT CAACGCTGTACTGGAGATCTTGCTGAAT ACAATATAAAAGAAAATAAATAAAAGGCA TAAATAATGGATAGATCACAGCACTGTGT ACCTTAATAAATGTAAAGGAATTCACAAA GACAATAACAGACCTAATAAGTGAATTTG ACATGGGTACAGAACACAAGGTCAATGT AATACATACATACACACATGAACAATCAA CAAATGGTTGGGAAATAAAATTGTTTAAA CACCATTTACAGTGAAATCTAAAAAGAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs 1037386 3 1453453 TA I I I I I CTGTGTGGCATATGCAAATTATT A/G GCCCTTTAAAAGCCATACCTAGAAATACC SEQ_0080

CTTTTCAAAGAATAATTATTTTAATAATAA AGTTGATTATTAAATCCTCCTAACTTCAA AAAATCATAATTATAATGACAACTGGTAG CTTCCTACCCTTTGTTTTGCTACACTTCTT TGACTTCTATAAATTAATCATTTCAAGTCT TAATAAAGATATTTATCAAGAAAGTGTCTT ACTATATTATCTTAGTTACTCAAAGGACT TCTATGGTTTACTGTATTGATGAAAATGA AAATCTTGATTTCTACGAAAATGGAAAAC AATCTAGAAATAAAGATACTTTTGTGTCT ATTA I I I I I I I GAAAGCCTACTCTGAGAA CTCTGTC I I I I I I I GTTTAATGTGGTTAGT CATTTGCCAGCTTGTCATATCCAGAAAAG TGATCTATAGTAAAACATACAGATACTAA TC GTATACACTTCAGTTATATATGTGTGTGT GTATTTATATATGCACCTGTTACCATCGT TAAAATTAAGATATAGAAATTCTCATCGT CCCACAATGTTTTCTCATGTTCCTTATTG GCCAATCTTAACCACCTACAGAGGTAAC CTGTAGCTTTAATTCTTTTACTGTAGATTA ATTTTGCCTGI I I I I GAAGTTATATATATA TATGGAATCTTAGTGTATGTACCGGTTTG TGTCTGGCTACTTTTGTTTAAAATAGTATT TT rs155847 1455753 TGCAACCCTGA I I I I I I I CTAACCTCACA C/T GGAGTCACTCAGATGAGGAGAATGGCCA SEQ_0081 * ATCAACATCCAAAGCCCACATGTGATGA AAAATTTCCTTGAGGTACTCAATAGAAGT GTAATTCAGGGGTCATAGTCTCTCTTAGG TTAAAAATGAAGAAATAACCCCAA 00 TCTGAGTCTTGTGCATCTTTTCACTCACC TGCGACAGCCCCACCCCCTTCCATGTGG AATGCCTACTCAGCTTTCAGATCTCAGAC TCAACACCTCTGGCTCTGGGAAGACATG AGGCTTTGGGAAGTCCGGGCTGGCTTTC CCTTCTAAGTGCTCCCACAAAGCCCTGA GAGCCCCTTATTCTTCACGCAGTGCATG GCGATTGCATGTCTCAACCACCAGGCCA CGTGTTTAGAGACGCCAGCCACACCCTT CCTTGTCTTCGTTACTGCTGCTGACAGCA TGCTCTCAGTACACAACCTTTGCGAGAAA GAATAAATGAGTGAGTGGAGAAGCACTA GCCATTTTCAGGGTGAATTGGTGGTAAT CAGATGCTGGAATTTGCTGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9990133 3 1456623 AGAGAAGCTGATGAGGTCTGAGATTACT C/G TGCCCCTCAATCAATAGAACCAGTTAAGA SEQ_0082

GAAAATACTACAGGAGCATTGGGATCAC AGAGACCATCTCCCAACCCTGMTAGGC

TGGGGGAGGGTTCTGGGGAGTCTGGAG TCAGTGTCCGAAGGTAGGTTGTGTAGAA

GATCTGGGGGACCTTGGGGGAAAGCGT ATGCATCCCCACAATCACAAGAATCAATG

ATGGGGTTTGGGAGCATGGAATGAACTA TGAAAGTAATATCAGGAGTΠTATTTCAG

GGGGAGCTAGGGGTGGTCATTGGTGGA CTATTGGTGGGTCAATC I I I I I I CTCTGT

GCTTGGACGTGCCTGGAGGAGCCTGGA GGAA I I I I I I I I CTTCCAAAGTTTCCTG

GGGATGAT rs718559 3 1469475 GTCTAAATTTGCTGTAACTGTCCATGATC A/G TTTTCTGCATTGCAAAGTCAAACTAATGA SEQ_0083

TTTTAAGCAGCTCTTCATCCAAGGGTATT TGAACACAGACCCTTGCTGCATGAGGTT

CTTTACCCTCTGAGATCCCATAAGCAATA AATAGAGAGAGGGACATGAGGG I I I I I I

TCTGTGATCAATCCTTGTGCCTATGAGTT CTATCCTTGTGTTTATTTTGTAGCCTCATA

TCTTGCAATGCCCCATTGTGTTAACAGCA TCAGATAAGCTT

TTATCTCCACTGCAATTCTGAAAACACAA GCACAATAGTTTGCTGTCTTCCTGAGACA GATGATGGACTCAGGATGAGCACCAGCC ACTTTGCATCCAAAACATGATAAACCTGT AACAGTCCTATTGGTCGTCTCCTCCGAC CTTAATTCTCATTGATTTTCTCTTGCTTTT

ACAAATACCTGAAAGAAACTCAAGTTGTC £-

CTGAAGATAAGAGCATGATCCGGACATG ^VO

AAGGTTTCTC I I I I I CC I I I I I IATCTTTG ATCTTTGTTCTGAGCCTTAGCTGAAGATC CTGATTTACAATTAAGTGGATTGGAGGAG ACTGTCT rs718558 3 1469483 GTCTAAATTTGCTGTAACTGTCCATGATC A/G ACTGTCTATTTTCTGCATTGCAAAGTCAA SEQJ3084

TTTTAAGCAGCTCTTCATCCAAGGGTATT ACTAATGATGAACACAGACCCTTGCTGC

CTTTACCCTCTGAGATCCCATAAGCAATA ATGAGGTTAATAGAGAGAGGGACATGAG

TCTGTGATCAATCCTTGTGCCTATGAGTT GG I I I I I I CTATCCTTGTGTTTATTTTGTA

TCTTGCAATGCCCCATTGTGTTAACAGCA GCCTCATATCAGATAAGCTT

TTATCTCCACTGCAATTCTGAAAACACAA GCACAATAGTTTGCTGTCTTCCTGAGACA GATGATGGACTCAGGATGAGCACCAGCC

ACTTTGCATCCAAAACATGATAAACCTGT

AACAGTCCTATTGGTCGTCTCCTCCGAC

CTTAATTCTCATTGATTTTCTCTTGCTTTT

ACAAATACCTGAAAGAAACTCAAGTTGTC

CTGAAGATAAGAGCATGATCCGGACATG

AAGGTTTCTC I I I I I CC I I I I I IATCTTTG

ATCTTTGTTCTGAGCCTTAGCTGAAGATC

CTGATTTACAATTAAGTGGATTGGAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9825372 3 1473979 TTGGCCTTTGTACAAACACTGCCAGCAG C/T TGTGAGTTGGTGACCAGGTACCAGGCCT SEQ_0085

TACATCACTTAGAACAGCACAGCACAGC TGTTTTGTCTACTTGTGTACTAGAATATTC AATGATTTCTATAACAGAAACATTAATCAA TCTCCCTTTCTATTTCACTAGTCACATGA TTAAAACCGGAAGTAAGCCAGCAAACAC TGACCACAAGTCATAGAGTAATA I I I I I I ATTTTACTGAGCTCACCAGCAAGTCATCA AACTTACTGCATAAATGGTGGGGTTTATC TCGCATAGATCATCAGATAGAAATGTTTC ACTTTAGTTTCTGTCACCTTAAAAAAAATA TTGACTAAAAAACAAAAAGAAAACTAAA TGGTTTCTTCAAAGAATTTAGATAA rs 12493849 1478175 ATCACGTCATCTGCAAACAGGGACATTTT A/G TGTTGTTGCCACTATAATCAGTCTGAAAC SEQ_0086 GACTTTCTCTTTTCCTAACTGAATACCCT ACAAATTCTGCCATGCCACTTCCCTGCTT TTATTTGTTTCTCTTGCCTGATTGCCCTG TAAAATTATCAAGGGCTTACAATTGTTGT GCAAGAACTTCTAACACTATGTTGAATAG CAGAATAATATCCAAGCGATTTTACCTGC GAGTGGTGAGAGAGGGCATCCCTGTCTT TGCGTGTGAATAGTATACACTTCTAGAAT GTGCCAGTTTTCAAAGGGAATGCTTCCA TTTGCTGCATCAAATGTTGCCATTAGCTA G I I I I I GCGCATTCAGTATGATATTGGCT TATGTAGCAATGTAGTTTTAACTTCAATT GTGGGTTTGTCATGMTAGCTCTTATTTT GAAATTAATTAAATAAAATTTAAACTTCAT TTTGAGATACGTCCCATCAATACCTAATT GTCTTCAGCTTCACTAGTCACATTTCAAA TATCGAGAG I I I I IAGCATGAAGGGCTGT TGCCCAATAGCCACAGGTGGCCAGAGG TGAATTTTGTTGAAGGCCTTTTCTGCATC CTATGTATCACACAGTGCAAACATAGATC TATTGAGATAATCATGTG I I I I I GTCTTTG ATTTCCATCTTCATAGAAAGTCTTAATAGT GTTCTGTTTATATGATGGATTACTTTACTT GCTGAGGTTCCATGGCCTCATATCTGTC O CTTAAATAG I I I I I I CAAATCAATCCAACT CACTACCCAACTATTTTCTTAAAATAGTG TATCCCTATTACTGTTTCTCTCCCTTGGA CTGAACAACTGGTAG I I I I I GAGTGAGTC TAATAACAGTGGTATTATAATTAGTCTTTC ATACATATTCATGTCTCTGTAGCTTTGCT TGACTCCTATCTTGTCCCTTCAAATCCAT CCTTCTAGTACTGTTTGGATTGCTCTTCA TCTCC TGTATTGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1961451 3 1478475 AAGGCCTTTTCTGCATCTATTGAGATAAT C/G ACAGTGCAAACATAGATCATTTCCATCTT SEQ 0087

CATGTG I I I I I GTCTTTGGTTCTGTTTAfA CATAGAAAGTCTTAATAGTGCTGAGGTTC TGATGGATTACTTTACTTCTTAAATAGTTT CATGGCCTCATATCTGTCCACTACCCAAC TTTCAAATCAATCCAACTTATCCCTATTAC TATTTTCTTAAAATAGTGCTGAACAACTG TGTTTCTCTCCCTTGGATAATAACAGTGG GTAGTTTTTGAGTGAGTCATACATATTCA TATTATAATTAGTCTTTCTGACTCCTATCT TGTCTCTGTAGCTTTGCTCCTTCTAGTAC TGTCCCTTCAAATCCATTCTCCGTGTTGT TGTTTGGATTGCTCTTCATGTATTGCTAG TGCCACTATAATCAGTCTGAAACACAAAT ATAATAGCCACTGAACATTCTTTAAGAGT TCTGCCATGCCACTTCCCTGCTTTAAAAT CAGCAAAAGTGTCACCTTCTCTAGAAGC TATCAAGGGCTTACAATTGTTGTCAGAAT CAACTCTGAAAAGTGGGCTTCAGCCAAG AATATCCAAGCGATTTTACCTGCTGCGTG CGTTTTCAAGGTATTCTGTGCATTTGCTC TGAATAGTATACACTTCTAGAATTTTGCT ACCTAACCATATCACAGAAATATTATCTG GCATCAAATGTTGCCATTAGCTATATGTA GTTTGTGCCTGACTTCCTAAGTGACAACA GCAATGTAGTTTTAACTTCAATTGAAATTA ATGGAACAAACAAACAAAMTGTCTTGTT ATTAAATAAAATTTAAACTTCATGTCTTCA CTGTGTTGTTTTATCAGCACCAGGCAAAA GCTTCACTAGTCACATTTCAAATGCCCAA TCTGTGGCATGTAGCAAGTGCTCTGATAT TAGCCACAGGTGGCCAGAGGCTATGTAT ATGTTTTCTGAAATGTAATAAATCATGTAA CA AGAGGCAA rs4502564 3 1480763 TCTTCTTTCCATAATCCAAGAGACCCACA CfT AGTGTTTAAGAATATATCAACAATGTACA SEQ_0088

CCAATTAATAAGTCATTAATATTAATTATA TTATGTCAATCTTATCATTTGAAAATTATT ATAATGCTAATGTTAGCAAGAGTTTATTG TTAAAATAAGACACAAATATTAGCTAATG TACGTTTAGTTTATGTCAGTCACTATGCT CACATTTACTTTTCCCTTTCTGACCTTAAT TAGAAGTGTATCCAAATTATCTCAGGCAA ATATTTAGTTATAAATTCTAATCTCTATAA TCCTCAAAACAATTCCATACAGATAGTAT AACCATTACCATAACTAAGAAATATCAGC TTTACTGCTATTTATCCACATTTTAGAGAT CAAACATTATATGAAAATAG I I I I I I I I I A AACAAAATTGAGACAAAGAGAGGCTATTT AGACTGTCAGTTGATAACGGAAAAGAAA AAGTATCACATCCATGGTCACACATCTAG GGAGCAAGAGTGTTATTGAGAAGTTATAT TAAATGTCAACGCTTTCTCATTCAAGCCC TACTGCACAAAGTAGAGGATTGCTTTGTG AGGACTGCCAAATTTCAAAATCCAAGCTC ATAGATTCTCTTTGAATCTGAGAAGTCAT CTAAACAGATACTCCTATTCCCCATTCTG TATTTCTAACAGTACATTTCAGATAACAC ATGTATTCAAGTTTAATTTTTGAACTATAA ATGCAATTAAAATGTCTTCTTTAATTATCA AAAAATCTATTTCCATGTCA CTAAAGAAAATTATTTCAA rs9854789 3 1485092 AGCCACATTTCCCTGTTAATTTATATATTA G/T GAGG I I I I I I I I I I I I I I I I I GTATGTAGA SEQJD089

TATAATGGTAGAGTGAGAGTAAACACTG GATCGAGCGCCATGTCTATCACAAAGCA GAGAGCACTTAGTCCAGCAAAGTA I I I I I TATGAGCTGATGTTTCCTGGACTTAACGT TGCATGAGATGGAGTGACGTGCCCAGAG ATATAACACTAAATTTCAGGAAAATAATTT TCACATGACTTGATAATGATAACAGAAGC AGCAAGGTAGCTAAATGCTTCTGTATATA AGTGGGGCCAGTGTAATCAGATTCCAGT GGAAATGCTGGGTACTGCACAGCGTAAT GCATGTACCTCCCAGTGACCTAAGAGTT CAAGACATTTTGTTTCTAAATCTAAT GGATGATGTCATTTCTCTTGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6763848 3 1487587 GACTGTTTTGTTCTTGATGGATACTTCAA A/C AATAACTGATGGAGAAGAATTTCATCTTT SEQ_0090

GGCAATCTTTTAGCAAAATCTCATACTTT AA I I ! I I CTGTTTTCTTAATCATGTGAAAA

TGCACAAACTTTTAAAAACTTTTAAGTTCA GGCAAATATAAAATAATGAAACAAACAGT

GAGGTGTAAGTGCTGGTTTGTTACATAG TCATGAAAAGAATTGGACAGCAGAGATC

GTAAACTTGTGTCGGGGGGGTATGTTGT TTGAGAAATCTTAGCCAATCAATACGGTC

ACAAGGCTTAATATTTGGGTGATAAATTT GGATAAGATTTATGAGGTACGAGGCCAT

AAACTTTAAAAACAATTAAAGGTATCCCT GTTAGCCGTGACTATTCTCCTTCTCCT

TATAGACTAGCAGTTAAGTGTGGCTGCT

CATTAGAAATACTTAGTGAACTTTGGGAG

GCCAAGGTGGATGGATCACCTGAGGTCA

GGAGTTCAAGACCAGCCTAGGCAACATG

GTGAAACCCCATCTCTACTAAATTCAAAA

AGTAGCTGGGCACAGTGGCGCATGCCT

GTAATCCCAGCTACTCCGGAGGCTGAGG

GAGGAGAATCACTTGAGCCCAGGTGGC

GGAGGTTGCAGTGAGCTGAGATTGCACC

ATTGCACTCCAACCTAGGCGACAGTGTA

AGACTCCGTCTCAAAAAAAAATAATAATA

ATAATAAATACTTAGTGAATTAAAGATGC

CTGGGCTCCACACCCAGAAAAGCTGATT S

CAGTGTCTGGGGTAAGGTCCCATCACAT ^W

CCGTA I I I I I CTCTTTCCCACTGATTCTA

CTGCCTAGCACTGTGAACTGTTACA rs11713863 3 1488667 TTATTCTACTTCTTCTTTGCACTGTTAATA C/T CCTGGCTCTCTAAAAAGAATGAACACATT SEQ_0091

CTGGCCTTTCCTGACTTCAGCCTGGATTA TATATCTTTATAGATATAAACTGGAGTTTC

TCCATTGCCTGACTGGGAAAGGCAGATT TTCCACAATGTAGGAAAGCCTCCTGTTCT

GTTAGAACATAAATGAAAGAAAGAGTCAG ACAGAATCACCCCCTAAAATAATAAGATT

TGCTCAGTTTCTGAGCTCCAGAATAGGC TTTTGAAAGAATAAGATGGAACAGTAAAA

CCTTGAAGCTCCTTTTGAGGGCAATCTTT ACCTACGTAACTTTGTAATCAAAGAACTA

GTGAAACAAAGCTTTTAATTTGCCAGA ATAAAAATAAAAATAATCCTAACGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Seαuence rs11707049 3 1489935 ATATATTTACATGTGTGTATATGTATGTAT A/G TCTGAGTGGCTCATCCTGATGGCTCCAT

GGTATATATACACACACACACACACACAC TAACAAATATCCACCCAACTCACCTCCAG

ACACACACACACCCACCCATGCAGTATA CACACATACATGCTTGCACACA I I I I I I I

CACGTATGTCAGCTCAGTTCTTGCAAGAA CTCCAAATTGGAAGGCCCTGATTTAGAA

GCAGACACTTCATTCAAGAAATTTACTGG GGACATAAAGAGTATCCATAAATACCTTG

AGGGAATAGACCTGTGAAGGAGAAACGG GAAAGCAGACAGAAGGGACATTTCTTGC

AGAAAGAGAAGGAGTAAGCAGGGAGAGT TGGACAAACTAAGAAAAGGAGGTATGTG

CTTTATACCACAAGTTAGGTTTGACACCT AAGAGGGTGCTTATAAAGCATCTT

GGGAAGGGGAAAGAAAAGAAGAATTGG

GCAGAAAGAGTCTCAGACCACAGCTCAG

GTTTGAAAACTTCTCTCCCAAGCCAATGA

CGAGATCCCCGAACAAGCTACCTATGCA

GAATCCTTCACTGGGCAGGAATGGGCTG

GCACTGGTGCCCTCACTCTCCTCAGTCA

CTGGCTGGCTGAAGTGCGTGGGAGTTGA

GGCCTCCACATTCTCTGGAGTAGCAGCT

TGAGCTCTTAGTCAACTGGGCTCTCCATA

GCAAGCTGTCTTGAAAT rs6786404 3 1490274 CCTTGGAAAGCAGACAGAAGGGACATTT A/G TGTCAGTCAATCACAATGTTACTGAATTC SEQ_0093 £

CTTGCTGGACAAACTAAGAAAAGGAGGT TACACATTGTGCCAACCAAAAAGCTATAT ^W

ATGTGAAGAGGGTGCTTATAAAGCATCTT TAGCCACACTTTACTGTGTTTCTGGGGA

GAATCTGGAGAAATCTTGGAGGAGTCTA GAGAATATCTGTAAAAGTTGCTTGTATGT

GTCCAGACCATTCAACTGGTGCTTGAGC TGATCTTTTAGCAGAAATGTTGCCCCCTT

AAGTGACTGATTCCACAACCGGGGTCTG GCACCATCTTTACAAATAATACCAACACC

GGATGACAGTGGGAGCTGAACCTACTGC AAAATATTAGATAACTTTCCTACCCAG AAA rs9310450 3 1490643 ACACCAAAATATTAGATAACTTTCCTACC C/T CTGTGATTCCTCTCTGTACTATTCCCCTG SEQ_0094

CAGTGCCCTAGGGCATTTGAAACAGACT GAAAATGCTGAGTTAAACCCCCTATTTCC

GCTTAAGACGCTTAGGCTGGGTGGGGGT AGATATCTGTCGTACATGATGTTAGTGAC

TGGGGAGGGTGGGAGCGGTGGGGGAGT TACTTGCTGTCACATAAGGAGAGAAGCA

GGTGGGAGGAGCATTGGTATGGAAGGA GCATTATTAGGAAGTAATAAAAGTACCTA

AAATCACACAATGCCCACTCCCCAAATAC TGTTGATAATACATAAACTCCAAGAGAAC

ACCCTTAACCTTGATGAAATTAAACAGGA ACTGTGCTGTAGTAGTATTTATAAAAC

ACA rs9310451 3 1490672 CAGTGCCCTAGGGCATTTGAAACAGACT AJG GAAAATGCTGAGTTAAACCCCCTATTTCC SEQ_0095

GCTTAAGACGCTTAGGCTGGGTGGGGGT AGATATCTGTCGTACATGATGTTAGTGAC

TGGGGAGGGTGGGAGCGGTGGGGGAGT TACTTGCTGTCACATAAGGAGAGAAGCA

GGTGGGAGGAGCATTGGTATGGAAGGA GCATTATTAGGAAGTAATAAAAGTACCTA

AAATCACACAATGCCCACTCCCCAAATAC TGTTGATAATACATAAACTCCAAGAGAAC

ACCCTTAACCTTGATGAAATTAAACAGGA ACTGTGCTGTAGTAGTATTTATAAAACAA

ACACCTGTGATTCCTCTCTGTACTATTCC TAGTTTCGTAAAGGCTCTGAGCATATT CCT

Supplementary Table 3

SNP Chr Position 5' Ranking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9310453 3 1490852 CCTCTCTGTACTATTCCCCTGGAAAATGC CfT GTAAAGGCTCTGAGCATA I M i l l I ACTA SEQ_0096

TGAGTTAAACCCCCTATTTCCAGATATCT AATTCAAGCATCTGCCATATGATTAGCCC GTCGTACATGATGTTAGTGACTACTTGCT TCACTATATCTGACAGAAGTAATAAACGA GTCACATAAGGAGAGAAGCAGCATTATT ATAACGTCTGGCCACGTACCATCTGCAG AGGAAGTAATAAAAGTACCTATGTTGATA ATAGCTTTGGTTTGGCCGGCATGGTCAG ATACATAAACTCCAAGAGAACACTGTGCT TCTTTAAGAAAATGAGTCACTATAAGGAG GTAGTAGTATTTATAAAACAATAGTTT CACTAACAGTACTGGCCTAGCACTCTTA rs17039921 1493064 ATAGTTTATGCTAGGTACTATCCTAAGTG G/T GAAGCAACTGATGCTCAGAGAATGTAAA SEQ_0097 CTTTATGTATATTAATTCCATCCTCATAAT TGTCTGAAATAAAGTGGAAGCCAGGCAT TATCCAGTCACCTAGCTTCTTTTGAGTTT GATGGCTCATATCTGTAATCCCAGTACTT TCATATTAGAAA TGGGAGACCAAGGCA rs552666 16383538 TTACAAATAAAGCTGGCAGAGCTAGAAG C/T GAGGCATTACTCCCCTCCCCATGCCTCC SEQJD098 CACATCTTTAAGCTGTTTGCCATCTGGAA CACCCTGGGACATAGAAAGACTTGTACA TGGCACTAGTCACGACTCCTGAATAGAG GTCCTCAAGTTTGGGCTCCTGCTCATGG ATTTATACTCCAAAATATTTTCCACAGGG TGTCCAGGACTCCTCTCCCTGGGTCGTT TCATAAAGCTCATGAGAACTGTGTCCCAT CATTAAACCTTAGAATGACCCGGTGTCTT AAACAAGGTGATGTTTCAGCCTGAATTAC GGGCTGGGGGAGGCTCTGCCCGTGGGC CCAGTGCAGACTCCAGAGCTTCTGTTCT TCTGGCAAGCTTAGGGCACAGAGGAGG GGCAT rs557007 16383994 CGCAACCGTGAAGTCCTCCACAGGGCCC A/C AATTCTCAGAACAAAATGAATTGAAACCC SEQ_0099 AGGCATCTTCCTGTATGCAGCCCGTATC ACTCTGACTTTAAACACCATTTCACCCTT TTAGAGCGCCACCATAGCTGTTCATCTCT TATATGTCTTTTGGGAGGGAGAGTATGA ATGTCAGGGAGGGCTGCA CTGGGAGTAATGCTTCCTGGGTTAGGGC GTTTCTGCTCTGGAAAAGTCCAAGGTTTC CGTTGGCCAGGGATGAAATACGTGTGTG ATCTTTTCCCAGAATTAAGAAAAAAAATG GCAAGCTAATCGTAATCATAAGAGGAAC CTATTTCTAGTGAGATAATTAGTGTCCTT ACAAATAAAGCTGGCAGAGCTAGAAGCA CATCTTTAAGCTGTTTGCCATCTGGAATG GCACTAGTCACGACTCCTGAATAGAGAT TTATACTCCAAAATATTTTCCACAGGGTC ATAAAGCTCATGAGAACTGTGTCCCATAA ACAAGGTGATGTTTCAGCCTGAATTACCC AGTGCAGACTCCAGAGCTTCTGTTCTTG AGGCATTACTCCCCTCCCCATGCCTCCC ACCCTGGGACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Seαuence SEQ ID rs4643693 3 16398763 AAAGTTAAATGCTGCCCTTATCCTATGCA CfT AGACGACCACATTTAGATTTTATGAAGAT SEQ_0100

TTCCAGGGAAATTCACACCCCCAAGAAG CAATATTTGGCTAGATCTAGGGGCCACG AGGAAGCATATTTGTAGCTCTGCTTATTT ACTCTTACAGTTCTGTCTTACCCTAGTAT CCTTCAAATAGATTCCTGGAAGTAGAATT AGACACTTTCCTCTTTTTCAGAAAGTCAT AATGAATGAAGGGATATTAACTTTTCAAA TTGACCGTGTACTTATGGCTAAAGTAAAT GGCTTGGCAGAGGCTGCCAAGTTGTTTA CCTGCTTCTCATTCTTGCATTTATAACCTT CCAAAAAGGGTGCGTAGTCC I I I I I AAC TACTGAGCCAGTCTCACATTCATCAT rs 17042200 16401895 GGGTTTGAGCTCACATCTGAAGCCGCCT A/G TTTTAGGGCCACAAGGAAAGATCATGTAA SEQ_0101 TTAGTTTTGACATGTTAACACTTAGCTGC ACTTTCTGCTGTTGTGGTTTTCTCATTTA AGAAATTGGAAGCTTTGCCAGGCGCTGC GCGACTGAGAGGTCTTAGAATCTGCCCT TGGATGTTTAGCTCC TGGACAAAGAGTTT rs 12629276 16403485 ATGTTCCTACACTCTAAGCTGTACTGGGA CfT GCTTAGATGACAGGCATGAACTGGGATT SEQ_0102 AATACCAGGGCTAGATTGCAGAGTCTTG GTCTGAACAAGCTGGGACATATGGTCAC CATCTTTAGAGTCTGGACTTTTTATTCTG CTGGTTCAGTGTGACCAGCAGTGAAGAC AAGGCAATGAGATGCCATCATGACTTCT CCAGAAAGCTGCTTTAAGAGGCACACAG GAGCAAAGTGACATGATCAGGCCTGTCC ATGAGTGTTCCTTCTCTTCCTTCCCTGTC TAAGGAAAAGAAATCTGCCCACAGGATG CATCACATGACCCACTGCTTCCATCACTC TGGTATGGATCGAGGTGGGGGTTGGTAA TCCTCCTATTATATCCTTGGCTTTCTCTG CAGAGCGAGGAGACAGGAGGCAAGGGA TCTGACACATCCCACAAATGTCGCATCCA CATGGCTGGGGCCCGGAAGTAACTGCA TCCAGTCCACCCAGGGCCACAAGGAGG GAGCTCATGGGAAAGGTCATAAGAGCCT AG ACACTTGCTATGGGAAAGGATGTGAGAA GTCCACGGGAGACAAAAAGTAGAGGCAG CAGTCTGTGACACACCATGGGATGCTGA TTTGTCAAACAACTGAAGCAAAAAGTAAA ATAATAATTA

Supplementary Table 3

SNP Chr Position 5" Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs689643 3 16406209 TCTTTATTAAAGCAGATCTCTGAAGGCTC A/G TGAATTCCGACATGCTTATGTTCATTTCT SEQ_0103

ACTCCTTCAGAGCTTTTGTGTTATCCTCG GGTTCATTCTTCTACTAGGAGAGAACTTT

TTTACATTTCTGTATATTTGAGTGTGCTG GAGAATACGTAACAAATAAAAATGAAGGC

CTAACTGCATCTTTTATAAAGGATTTAGA GAGAAGTGGAAATAAATTCAGTATTGAAT

TTTTACACTTTACAAAATCATTGCAGTCT ATAAGGGTTATTGGACATTGAAGATAATC

GGTATTTCCTGTGGGTATGGATTAGTGA TTTAAATGTATAATTCTCAGTAGTTGTTAA

CGATCACTGTATTTTAAAAGATGTCTATT TGCAAAGCTGTTCCTTCCCTCCCCC

GCTGTGTAACAAACCACCCCAAAACATAT

TGGCTTTAAACAATAGCAGTCATTTATTTT

GCTCACAAATCTGCAACTTGGGCAGTAC

TTGGCAGAGGCAGCTAATCTCCATTTCA

CATGGTATCAACTGGGCTGTTTGGTGGT

AGCTGGGGGATCTACTTTCAAGATGGCA

CACTCATATGGCTGGCAAGTTGGTGTTG

GCTGTAGGCCTCTCGACAGACTGCTTAA

GGCTTCCTCAAAACATGGCAGCTAGGTT

CTAAGAGCAAGCATCCCAAGAGAAGAAG

GTGGAAGTTCATGGAATTCTGATGATTAT

ACCTTGGAGGTCACATAAGGGTCCTΠT

CACCTACTCATTGGTTGAGGCCGTCATA S

AGGACCCATAGTGGTTGAAGTACAGGGG ^

ACATGGGTTCCAGCTCTTGATGGAGGAG

TGACAAGGTTCCAGCAGACCATGTGGAA

TGAGAAATATTGTTGTGGCCATCTTTGGA

AAATACAGTCTGCCACATAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SE( rs523909 3 16406425 ACCTCTTTATTAAAGCAGATCTCTGAAGG A/G GAAGTTCATGGAATTCTGATGATTATACC SEQ. 0104

CTCACTCCTTCAGAGCTTTTGTGTTATCC TTGGAGGTCACATAAGGGTCCTTTTCAC TCGTTTACATTTCTGTATATTTGAGTGTG CTACTCATTGGTTGAGGCCGTCATAAGG CTGCTAACTGCATCTTTTATAAAGGATTT ACCCATAGTGGTTGAAGTACAGGGGACA AGATTTTACACTTTACAAAATCATTGCAG TGGGTTCCAGCTCTTGATGGAGGAGTGA TCTGGTATTTCCTGTGGGTATGGATTAGT CAAGGTTCCAGCAGACCATGTGGAATGA GACGATCACTGTATTTTAAAAGATGTCTA GAAATATTGTTGTGGCCATCTTTGGAAAA TTGCTGTGTAACAAACCACCCCAAAACAT TACAGTCTGCCACATACGTGAATTCCGA ATTGGCTTTAAACAATAGCAGTCATTTAT CATGCTTATGTTCATTTCTGGTTCATTCTT TTTGCTCACAAATCTGCAACTTGGGCAGT CTACTAGGAGAGAACTTTGAGAATACGTA ACTTGGCAGAGGCAGCTAATCTCCATTT ACAAATAAAAATGAAGGCGAGAAGTGGA CACATGGTATCAACTGGGCTGTTTGGTG AATAAATTCAGTATTGAATATAAGGGTTA GTAGCTGGGGGATCTACTTTCAAGATGG TTGGACATTGAAGATAATCTTTAAATGTA CACACTCATATGGCTGGCAAGTTGGTGT TAATTCTCAGTAGTTGTTAATGCAAAGCT TGGCTGTAGGCCTCTCGACAGACTGCTT GTTCCTTCCCTC AAGGCTTCCTCAAAACATGGCAGCTAGG TTCTAAGAGCAAGCATCCCAAGAGAAGA AGGT rs13081740 3 16408494 AAAATTCACAAAATGAGGGTATATGGCAC C/T TAACTGGAATCAGGAGAGAATTCTGGAA SEQ 0105

CGAAACGCAGCACACCACTATCATAAAC CTGGGTTTAAAGTTCCAGATTTCTTGAGG CTGAACTAATCAAATAAGGCTCTTTGATA AGGCAAGTCAGTTTCAATAATTGAGTATC ATGAAGGGGAAGTCATTTAAAAGCTGGA TCATCTCCAAGTGCTTTCTCCCTCCCTGC TTGACCATAGACTCACAGAATATCAGAGC AGTGTCCTCTAGCCATCTTCAGCCCTGC TATAGGCAATCCTAGAGATTATCATTCTA TGACTCCAATCCTAATGGGACCTGGCTC GTGCAAAGG I I I I I I I I I I G I I I I I I I I I I TTTGAGTGGGAATTCTCCCAAAGGCAGA TTG I I I I I I I I I I I G I I I I I I I I ACGGGGA A AGAAAGCTAAGAATTTCAGAAAGTGAAAC ATCCCACCTAAATGGCTGCCTAAGTTATT AGGTAGTAGGTTTCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS1864259 3 16408523 GGTTTACAGCACAGGTTGAACTTTCCCAT A/G TTCCAGAATTCTCTCCTGATTCCAGTTAA SEQ_0106

CTGTGTGTTCAGAAGTGCTGAACATCCC AGAAACCTACTACCTAATAACTTAGGCAG ACCTCGGTGACACCTCCTGTCTGGGATC CCATTTAGGTGGGATGTTTCACTTTCTGA CAGCACAGATAATGAGTGTGGGAATTTG AATTCTTAG AACTAACCTCATGGCATGTGAGGGTGGG GTGTCTTGTCTGAGAAATGGAGTGTATC CTGGCAGGCAGTTAGGCTGCCTGCTGTA TCTTCCCCTGACACTGGAAGGTTTCATTT TAATTGCTTGTGATTATGTAAAATCTTTTC TGAGGGTTTTGAGAATCAGTGTGACAGA ATTACAACCCACATAAGGTΠTCCCCTTT TCTGCCTTTGGGAGAATTCCCACTCAAA GAGCCAGGTCCCATTAGGATTGGAGTCA GCAGGGCTGAAGATGGCTAGAGGACACT GCAGGGAGGGAGAAAGCACTTGGAGAT GAGATACTCAATTATTGAAACTGACTTGC CTCCTCAAGAAATCTGGAACTTTAAACCC

A rs4684279 3 16409634 TTGCATCACTGTTCACAGCATCTGTTCCC A/G TCTTAAGAGGTGGCAAGAACTTTAGGTAA SEQ_0107

ATACAATTCTGAGGCCCTGCAAGCCTTG AAGGAAAATAGAGGAGACAAAGGGAGTC GAAACACACAGGCTCTTGCTCTTTCATTC CAAAATACTAGGGTAGGGAGTGGCAGGA TATAAACATTCACTGAGCACATGCTAAAT GGCAAGCTGCTCTCTTAAAGATGGGTGG GACCTATTCTGAGCTCAGCATCAAACAAA GAAGGTAGGTGCACTGAGGTAACCTGGA CAAACAAACAAAAAATGACAAGAAACAAT ACGAAGATTTGAAGGAGGTGAAGGAATC ACACACAATAAGTAAAAACAGTAACGT AGCCAAGCAGATATCTAGGGATAGATGC ACC rs2063776 3 16411059 GTAACATAGCATGACCCCATCTCTATAAA C/T GGAAGGGGAGTGGGGAATTGTGGGCGT SEQ_0108

AAAAATCTTAAAAAAATTAGCTGGGTGTG GGCTACAGGAAGGGTTCAGGCTGTTGCT GTGGTGCACACCCGTAATCCTAGCTGCT CCTGCTCTATTAATATTTCTTGAGTGTTG TGGGAGGCTGAGCAGGGAGGATGGCTT GTTACTCAGGTGTGTTCATTTTGTGCTAA GAGCTCAGGGTTTGAAGCTGTAGTGAGC CTCATTGAGCTGTACACTTATGATTTATG TATGACTGCACCACTGCACTCTAGCTTG CACTCGCCTGTATTGATGTTATTTTCAAT GGCAACACAGTGAGACCCTGTCCCTTAA AAAAAGAGGTGTTTTCTA I I I I I I I I I AAG AAACAAACAAACAAAAAACAAAGCAATGC AGCAATGTGAAGTGTTTCCATTATGGAGA AGGAATTCTACACACAAATGAACACCAAT TTTCTTATTGACATATGAGCTGGACAAGA GAACCACTGTGACATAAATGAATCTCACA AAA GACACAGTGCTGAGCAAAAGACACCATT TATACAAACAGGCGAAGCCACCCTTTGG TGTTAGAAGTTAGAGAGGCTTCCCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs 12488145 3 16411729 ATAAAAAGAGGTGTTTTCTA I I I I I I I HA A/C TTGTCTTTTAGATCTTGGCATATATGCCT

AGAGCAATGTGAAGTGTTTCCATTATGGA TATATTGCTCTGTGCTCTGCCTCCCCTTA GATTTCTTATTGACATATGAGCTGGACAA TGACTGAGAAGACTCAATCACAAATGCTT GAAAAATCAACTCTCCTAATGTTATGTGA TGTATCAACTTAGAAATTATGAAAAACTG CTGAGCACTTATGACTCAGGACAGAATTT AAAATTGTTTAAATAAATGAATTCTACTAA CCAGAGATAGCATCATTTATGAATTTTAA AATATGCTGTCCAAGATAGTAGCCATATG AAGTGCTGAATCCCAAACAATTTGGAAGA CCACATGTGGTTATCAAGCACTTAAAATA AAGTAAATAGGATGAGCTTGAAACTGTGT CGACTCATGAGACCAAGGAGCTGAATTT TAGATAGCCCTGAAAATCATGCTGGTGAT I I I I I I I I I IAAAGAGACAGGGTATCACT GATAAAGGCAACCAAGTGCAATAATACAT CTGTTGCCCAGGCTGGAGTGCAGTGGTG GAAAAAAAAGTACAGAAATAAAATTGTTC TGATCATAGCTCACTGTAACTTCGAACTC CATGAGATTTAAACACAGGGGAAAAGCA CTGGAATCAAGAGATCCACCCCCCTCGG CCATTTCCAAGTTTATACAATTTATATAAT CCTCCTGAGTGGCTGGGATTACAGACAT TTAAAATATGCATGTGCAATTAAATTATTA GCACCACCATGCTCAGCTAATTTTATTTT TAAGCAGAAATTATTTCAAATATATTCCTC TTA I I I ! I GTAGAGACAGGGTCTTGCTAT AAATGTTATATGCCAAAGTTGGCCCCAAA GTTGCCCAGAATGGTCTCAAACTCCTGG C I I I I IAAATG I I I I I CATGGGAAAAATAG CCTTAAGCAATCCTCCTGCCTCTAATTTT GAG AATTTTAAAAT rs 13082467 3 16412045 GTTCCATGAGATTTAAACACAGGGGAAA C/T TCCTGGAATCAAGAGATCCACCCCCCTC SEQ_0110

AGCACCATTTCCAAGTTTATACAATTTATA GGCCTCCTGAGTGGCTGGGATTACAGAC TAATTTAAAATATGCATGTGCAATTAAATT ATGCACCACCATGCTCAGCTAATTTTATT ATTATAAGCAGAAATTATTTCAAATATATT TTTTA I I I I I GTAGAGACAGGGTCTTGCT CCTCAAATGTTATATGCCAAAGTTGGCCC ATGTTGCCCAGAATGGTCTCAAACTCCT CAAAC I I I I I AAATG I I I I I CATGGGAAAA GGCCTTAAGCAATCCTCCTGCCTCTAATT ATAGGAGCTTGTCTTTTAGATCTTGGCAT TTAATTTTAAAATGAAAGCAATATGAAATA ATATGCCTTATATTGCTCTGTGCTCTGCC I I I I I CTGTTAAGTACAACTTTACTTTGTA TCCCCTTATGACTGAGAAGACTCAATCAC GAATATTTCGCTTCAATTATTGAAAAGTTA AAATGCTTTGTATCAACTTAGAAATTATG GCATCCAAATTGAGATGTGATTTAAGTGA AAAAACTGAAAATTGTTTAAATAAATGAAT CACCAGATTTTCAAGACTTTGGCCTCCCA TCTACTAAAATATGCTGTCCAAGATAGTA AAATGCTGGGATTATAAGTGTGAAAACCT GCCATATGCCACATGTGGTTATCAAGCA GATGTCACTTGAAGCCTTGAAAGAAACCT CTTAAAATACGACTCATGAGACCAAGGA GTAAAAACTTGTAAAAAATTTTTTAAAAAG GCTGAA ! I M I I I I I I I l TAAAGAGACAG TAAAATATCTCATTATATGTTGAAAAGATA GGTATCACTCTGTTGCCCAGGCTGGAGT CTATTTTGGATATATTGGGTTAAATAAGA GCAGTGGTGTGATCATAGCTCACTGTAA CTTATTACTAAAGTTAATTTCACTCTTGTT CTTCGAA TTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 13062819 3 16412272 GCTCTGCCTCCCCTTATGACTGAGAAGA G/T TGTAGAATATTTCGCTTCAATTATTGAAAA SEQ_0111

CTCAATCACAAATGCTTTGTATCMCTTA GTTAGCATCCAMTTGAGATGTGATTTAA GAAATTATGAAAAACTGAAAATTGTTTAA GTGACACCAGATTTTCAAGACTTTGGCCT ATAAATGAATTCTACTAAAATATGCTGTC CCCAAAATGCTGGGATTATAAGTGTGAAA CAAGATAGTAGCCATATGCCACATGTGG ACCTGATGTCACTTGAAGCCTTGAAAGAA TTATCAAGCACTTAAAATACGACTCATGA ACCTGTAAAAACTTGTAAAAAA I I I l I I AA GACCAAGGAGCTGAA I I I I I I I I I 1 1 I IAA AAAGTAAAATATCTCATTATATGTTGAAAA AGAGACAGGGTATCACTCTGTTGCCCAG GATACTATTTTGGATATATTGGGTTAAAT GCTGGAGTGCAGTGGTGTGATCATAGCT AAGACTTATTACTAAAGTTAATTTCACTCT CACTGTAACTTCGAACTCCTGGAATCAAG TG I I I I I ACTTAACATGACTATTAGATTTA AGATCCACCCCCCTCGGCCTCCTGAGTG AAATATACATAGATGGTTCACTTTATAAG GCTGGGATTACAGACATGCACCACCATG ACAGAGTTGCTAAGGAATAAAATGCCATT CTCAGCTAATTTTATT I I I I A I I I I I GTAG TTTGATCAGAGACCTCAGGGGAGAGATA AGACAGGGTCTTGCTATGTTGCCCAGAA AAAGAAAGAAAAATCAAACCTGGAAAGA TGGTCTCAAACTCCTGGCCTTAAGCAATC CTGATATTTGAAGATCTGATTAACAGCTA CTCCTGCCTCTAATTTTAATTTTAAAATGA TGGCAGAAAAAGTCCAGGAGTCAGGAGA AAGCAATATGAAATA I I I I I CTGTTAAGTA AATATGAGAAAGCAGAAAGGAAAGGGAG CAACTTTACT AAACCA rs1594090 3 16413851 ATCACCTGAGGTCAGGAGTTTGAGACCA GfT GGCAGAAAGGAAATGGGGAGATGTAGGT SEQ_01 12

GCCTGGCCAACATGGCGAAATCCCGTTT CAAAGGGTACGAAATTGAAGATATGCAG CCACTAAAAATACAAAAATTAGCTGGGCG GATGAATAAGTCTGGAGATCTAATGCACA O TGGTGGCAGGTACCTGTAATCCCAGCTA GCATGAGGACTACAGTTAATAATATTTTA CTCGGGAGGCTGAGGCAGGAGAATCGC TTGTATACTGGAAATTTGCTGAGAGATTT TTGAACCTGGGAGGCAGAGGTTGCAGTG TAGGCGCTCTTACCGCAAAAATGGTAAC AACTGAGATTTCACCATTGCACTCCAGCC TATGCAAGATATATTAATTTGCTTAACTAC TGGGCAACAAGAGTGAAATTCTGTCTCA AGTAACCATTTCACTATGTGTATCAAACA AAATGAAAAAAAAAAAAAAAAAGAGAGAG GCATGCTGTAAACCTTAAATATGTACAAT AGAAGAAAACCTGTCAACAGATGAATGG AAAAATAAAACTTAAAAATAAATAGAAAA ATGAAAAATTGTAAGAGGTATATGTGTGT GAGAGAAGAAACTGACCACACCCCCGCC GTGTCTAATGGAATATTATTCAGCCTTAA CACCCCACTGACTACCTGTGATTTTTCCA AAAATATCTTGCCATTTACAACATGGATA TGGTTGGTAGGTGGTCAATAGATTCATCA AACCTAGAGGACATTATGCTAAGTGAAAT TTGATTTGGTACATTTTCCGAAGTATGTG AAGGCAGACACGAAATGAAAAATAGTGC CTATGGTATAGATAGGTATTTGGTCTCGG ATGATCTCACTTATATGTGGAATCAAAAA TCTCTCTCCCTCTCTCTCTCTCTTTCTTTT AAAGAAAATATCAAATACATAGAAACAAT TTCTTTCTTTCTCTCACCTTGAAAAATAGA AAAACACTGGTTACTA GCGGTATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs735592 3 16416667 CTGCTCCTGAAAGCCCTCCAGCAGCTTT C/G TATGGGGACCCGACTCACTCTCCAGCCT SEQ_0113

GCACTACACTTAGGATAAAGGGCCCCAT CACTCCACCTCACTCACCCCTCTGTCATT CCTCAGCCTGGCCTGCAGGGCT TGCAGGCAAGACAGTGAACTCCCTTCTG CTCCTCAAACCAAACTTACTCCCTCCCAC CTTGGCTTTGTCTGAGCTGCTCCAGGAG TCCCCACCACCTCCACCCTCCCTCCCCT GTTGACCCTCAGGTCTTGGTATGTACACT TCATGGAGCACTCCCCCAACACTGCCAG CCTGGGGCAGGCCCCTTGCCATGTTCTA CTCGACAGCGCTCACCCATCTGTGATCC TACAACCCTCATGTGCCCATCTGCTCTGT GTCTGTGCCCTCAGCTAGACTCTAAGTTT CACGTGTCCAGGACATTACCTAGACCGG CTTACTAAAGTATTCGCAAACACTACCAG CAAAGATCTGTTCAAAGAAATGTGAACGA AACCTGACCCACTGATGCTGGACAGTAG ATTCCCGCAGAGGGAGAAAATGAAGCAC AAGAAAGGATCTCC I I I I I I GGGGAGTG ATTGAGACAAGCGTATGACCCCTTTCCCT CCTCCGGCTTAAATAACTTCAGCGAACCT CTCTGGACAGAACACGAAGATCACAGGG CTATAAAATAGCACGAGACCCAGGATCA GAACGGCCCCGGTGGGAGA rs4685334 16423594 TAATGAATCATCAGACACACATGTGCATA C/G GGCTGTTTCCTGAAGAACTGAGACAGGA SEQ_0114 CACACATCTATAATCAGTGGGAAAAAAAG CCACTGCAATGGGTCAGCCATGCAATAA AATGCTGGCATAAAAGTTAAGATAAAAAC CCTAATTTGGTTAAGACAAAGTCACCAAC TGGCTAATGTCCTTCAGGGCATAAAAAC TCATATCAACTCATATGTTTTCTTTCTΠT CCTAACTTTGAGGGCCTTTCCCACTGGA AAGAGACTGGGTCTCACTCTGTCAGCCA CAGATGGACATCTCCACTTGGGTACTAC GGCTGGAGTGCAGTGGTGCAATCATAGC AGAAACAACACCCCAGTAGCTCGCAAAT TCACTGTGGTCTCAAACTCCTGGGCTCA C A rs17042252 16435774 GTTGCCTGTAACTCAGCAGAGGCTGTAA A/G GGGCAGAATAGTGGGAAACAAAGTTACT SEQ_01 15 TGATGAGCCTAGGGAACGTGTGGGTGAA GAGAAAGGACGGTACTCGCCTTAACTGT TCCACTGTTAGAACGAGTCTGTGACTGT GAAGTAAAGAAGAGTCATGGGTGGCCTT GGGCTCTGCAGTGACC AGAGAGAAAGATACTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9848415 3 45803845 GTAATGTCTCTGCCACTGTGAGTCCATAT A/G CCTTCTCTGTCCACCCTCACTAGAACAG SEQ_0116

TACCCCAGATGAGTGGGACGCTTACAGT CCTTCTTGCCATCTTGGACTCCTTACCCT

CACAGAATTATTGGAAGATGTAGACTCAG GCTTGATTTACCTTCTGAACATTTCCCTA

CTCAGCCTGGTGAATCCTTACTCATCACC TGTGAATAATGCTATAATTTTCTTTGTTTA

ACCTCCCTGGCACCCACTGTCACATCTC CTTGGTGTCTGCCTCTCTACTAGCAAGG

CACTGCACCGCCCTCCAGGCAGGTCTTT AAGCTCTCCTCTTGTTCTCTGCTCTGCTT

GTGATTCCACCCTCCAGTCCCCTCCCTG AGAACAGCACTGGGCAGAGAGCCAGAG

CAGTTTGTTCTCAGATTGTGACACACCTG TCCATTGAATATTTGTTGAATGCAGGAAA

CCTTTTCCATCCCTAGCTTCTCACCTGGT GAATCCTTAGGGTCTCACTGGATCTTCCA

CAAATCTTCCTTGGCTCCTCCTTCCACCT GATGCATCACTTCCTCCAAGTGTCACCA

GGAATCAAACCCATACTCCCTCCCTTGA GATCACTCAAAACTAAGACCCACCCTCTT

CCTCTGAGGCTTGGGGAACAGGGCTCC GTCTTGCAAGCCCCTGTTGTTGAGGCAC

CACCTTCCCTTCCCTGCCGCTGGCCTCT CTGCCGCTACACTGAATGTCTACTGCTCT

CTCCATCCACTGCAGTCACACTGGCCTT GTCCACACCTCCAACTCCTAAACAGTCA

CCTGCTGGTCTGGCCTCAGCACCTTGGT GCTCCTTGAGGGTAGAGATGGGATCTGC TCTTGCTGTTCCTCCTGCCCAGGATGCTT TCTCTCTTCTTTCAGTGCTCTGCCCAGAC TTGGCTTCCCCAGAGCC rs7644870 3 45805890 AGTATACTTTCCCCTCAAATTTAAATTAAC A/C TAATAAATATAAACGGATCAAATTCCTCC SEQ_0117 ^

TGCTAATAGAAAAAATAGGAATTATACCT ACTAAAACATGAGGACCACTGGATTATAA ^

TCTAAATCACTTGAGAAAAAAAGTGAAGA CAGCATAAAACTTTACGTGACTTAAACTT

ATATATACTTCATAATGTAAAAGATCAAAA CCACAACTGGAGAATGGTTAAGTAAGTTA

CAAAATCCAACAATAATAACTAACAAAAA TGTTACCTCTGTAAATGGAATATTATGGA

GGAAAAGTAAGGCAGTACGAAATGTGAT GCTATTTAAGCTTATATTTTCAAAAAATAT

GAAAAATAACAGCAAACATAACCTG TACATGATTTTGGAAAGGATTAAAATAAG

TTAATTTTGAAAAAGCAAAATACCAAGTC ACATATAAAAATATGGTTCTAA I I I I I I AC AGCAAAAATGTTAACAGTCATTACCTCTG GGTGGTGGAATTTCTGGTGATTTCGTATT TTATTATTTGTATATTTCTGCATTTTACAG AA I I I I I I CCTAACTTTTATA I I I I I AGTA GAGATGAGGTCTCACTATATTGCTCAGG

CTGATCTTGAACTCCTGAGCTCAAGTGAT

CCTCCTGCCTCGGCCTCCCAAAGTGCTG

GGATTACAGGCATGAGCCTCCACACCCG

GGCCCCCCTTTTTTTTAACCAACCAAAATTTTTTCCTTAACCGGAATTGGAAAACCAA

CCTTCCAATTTTAACCAATTTTTTAATTAAAACCCCCCCCCCAAAAAACCTTCCAACC

ACCATATGTTATTCTAGAGCATGTTGTTG

CCTTTTAA I I I I I CTAATTATCATAGCCAGTACG

^• TTTTGGTTCTATTTGCTAAACCTAAGAATCTCA CTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1860263 3 45807056 CAAGAGGATCTAGAAAGCCTTCCAGCAA A/T TTTTCTCACCTGTGCCCTTGTTCTTGGTT SEQ_01 18

TGGCAACATTTAATAGCAGCTGTGAAAGA TTCAAAAGGTTGACTGGGTTTGACTCCAA

GAAGTCAAAGCTCATCATGTAGAATTAGG ATGGGAAACTTTTGGGGGAAGACCAAGA

GGTGAAAATATTCCAGGCAGAAGAAACT TGGAGGCGAGTGAATGAAGAGAAGGAA

GTATGCAAAAGGCACAGAAAAGCACACA GGCGCTGGGGTGGAGAGTCTCACAGAA

TTTGAGGGAAATGGCCAGAAACCCCAGG TAGAGCAGTGGTTCCCAAAGTGGAACCC

TGGCTGTGAGAAGTGAGGCGGGGACTA CCAGGCCAGCAGCTTCAGCATCCCCTGG

GGGCAATGGCAGGAGAGGAAACTGGAG TGTGCTCGGTGTTCCTTACATTAAACATT

ATGAAAAAGGAGTCAGCATGTCCCTAAG ACATTAAACATTGTGTATATGCACAC

GGCCCCAAATAACAGGCTAAGAAGGTGG

AGCTTAGCTCTGACAGCAAAGCCAGATT

TTAAGCAGGGAAGTGGCACAGTCAGAGC

TGTGGTTTACAGAGATTGCCAGCATGGA

GGCCAAGGATGCACTGGGTAGCTGGAG

AAGGGGTGATGCTGCCCGAGGGGATGA

GCAAGGAGAGCAGAGAACAGATGGGAG

GGAATTCTAGGAGGTTTAAACCAGTGAC

AGTCAGGAAGAGTAAAGACGGCTTTAA rs13064991 3 45809815 AGCTGGCTTCCTGTCCCAGACAGCAAGG G/T GTTTATGTAAAATAGTTAGTGCAGTATTT SEQ_0119 ^

GCTTTGCAGGGATGTGGAGCATTCCAGT GC I I I I I ACACCTTAGTGCACACACACTT ^W

CTGAGAGTGATACTGTCCCACTGCATAG GCATCCCCGATTTCTTCCTGAACAACTAC

TCAGGTGTCCTCTGATTTCCCCCTCAATA TGCCTTAGATTTTGACATGGTTGCCCAAG

TTGCAGAGAGAAAATTTAAGAGAAAAAAA ACCTGCTGACTTTTTCAAAAAGAGATTTT

TCCATATTTCCACCAGTCACACAACTGTT GTGAAGTTCTTTGAGCTGCCTTTTATTTT

CTCATCTCTCCATGTTTCTTCCGTGCACA TTA I I I I I CTAGAGCAGGCAGCCAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12633693 3 163444104 AATAATTTCCATGTCTCTCTAGTGAAGAA A/G CTTCTTACTTACATAAAAGGATATACGTG SEQ_0120

ATGAAAATTATTTGTTAAGGTTTCATCAGT TGACTACTAAAATATTACAGAAATCTATAT

GCTTATTGCTTTGTAGCTGAAGGTTAGTT GTGCATCTGTGTATATTTATATGTATGTG

TTAAACCTTTCCATTGGGCTAGCTCCTTC TATGAGAAAGGAAAGTATTCTTAGGGCC

CTCCCTAGAGCAAGTGAGTTTACTΠTCC CCAAAATCACTAATCTACATGGAAAAGTC

ACCTATGAGTATGATAC I I I I IACAAAAG AATCTGGGAACTGCTTAGGGCAAACCGG

GTAACTATATCAAACAC I I I I I I I I I I I AC CCTCCCATTCTACTCAGTTATCCCTGTGC

AGTCTTGCTCTGTCACCCAGGCTGGAGT TCACTGAAATAAATGTATATCTGATTGCC

GCAATGGCACAATCTCGCCTCACTGCAA TTCTTTGGAAAGTCTAATCAGAAAAAAAG

CCTCCGCCTCCTGGGTTCAAGCGATTCT AATGCAACTA I I 1 I I GTCTTATCTACCTAT

CGTGCCTCAGCCACCCGAGTAACCAGGA GACCTGGAAGCCTCCTCCGTGTTTTGAG

TTACTAGCGCCTGCCACCATGCTTGGCT TTGTCCTGTCTTTGCTTAGAGTTGTCCCG

AA I I I I I I GTA I I I I I AGTAGAGACGGAG CCATTCCGGGCCAAACCAATGTTCATCC

TTTTGCCATGTTGGCCAGGCTAGTCTCG TACACGTACTGATTGATGTCTCATGTCTT

ATCTCCTGAACTCAGGCAATTCACCTGC CCTAAAATGTGTAAAATCAAGATGTGTTC

CTTGGCTTCCCACACTGCTAGGATCAATA AAACCAGCTTGGGGACATGTTGTCAGGA

AAC CCACCTGAGGCTGTGTCATGGGTGCACT

TCCTCAACCTT

ΓS12493358 3 163451664 CTCATACTAAATCTCTCTGTTGAACCAAC C/G TGTAGTATCCCAGAAGAGAGAGGTAGGA SEQ_0121

TGGACCTTGACTGAGTTGAAATCAAAGG CAGAGATATCTGATGATGCAGACCACCA ^

GAAAAGGTCACACTGGTTCACCATCAATT ATAAGAAGCATATCTAACGTTTGATTTAA ⁴^

TGAACTTAAATCAGTCAGTCCTGAAAGAT GGCATCTGTCCGCAAAGCCTATGATCTTT

TTAAGTTCACTTGGGTGTTCTTGGTTTAA CTCTAATCCAACAGGAAGATGTGCCATC

ATAATAACCAATATGTGGATGATGATTAA CCCTTGATAGCTGGAGGGTATGATAAAA

A I I I I I CAAATAAATCTTATCTGTTCA TGATGGTATTTTAATTACTTACGAGCAAA

G

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11927519 3 163455199 GTGATGAGAATTGATTATGCCTCAAGAAA A/G AATGTAGATATCTTTTGAGGACA I I I I I IA SEQ_0122

GACAACACATACCTGATTACAATCCCAAC GCCTACCAGTATCTGCTCTTTGGAACTCA ACTGATAATTAACAACGTACTGGGGCTG AAGATTCATGTCCATCCCACATGCAAAAT AGAAAACAAATCAACTTGTGTGTCAAACA ACGTTCATCTTATTCCAATATCTTTCAAAG GATATTGGAGCACAGTTGATTGAGCAGA TACTAACCCATTGTAGTACCAACTTAGGT TAGAA I I I I I GTGTCAC I I I I I CTTGTATA TCACAATGCCATTTAATTATTATAAACTCA TTTAATCTTTCATGAAACTGCCGAAGTGC AAAATTTCAAAGCTCTTTATCTAAATAACC TCTTTAGGTACATGTATCATTTTGTAACA TAAGTTAGGTATAGATGAGTCTTTGGGAA CATACCCTTAGCAACATATAAACATTTTA TAATTACTCAGTGGATTTTCTCTCCATCT GTTTCTTTACAACTAAATAATAGTTGTTAT GTGGACCTCTCAAACTAGAAAAGTAATCA C I I I I I I AATTTTAGCAAATTTATTGTGTA TGCTTTCCAAATACAATGGTGGGACAAG TTGATATTTCATTATTATTTGAATTTGTATT CATACAATAATAGTATAGCTATTTCCATTT TCCTTGATGGCTAAAGATGTTCAATCTCA TGAAAGGGATAAAATGTAGGAAAGAAAC CAGGCATTGAAACATAGGATTACAGATTC ACTAGTCCCAAGCAATTTTGAAATGTAGC AAAAAAAAAAGAAATGTTTTCAAGGCTTG GGAATAATTTCCAGTGGCTTTAGGTGGC ATCATCTGGACCTATTGCTCTGCTGTTTT TGCCA rs883441 163463610 AGAACAAATTACGCTTTAAAAGTATCTTT C/G GGTAGCAAGCTGATTACAAGGCTTTCTG SEQJ3123 GGCATGGTTTTTATAAGACCGCCTCATGA CTAGCTCTACTATTGGCATCAATACTACC AGAAGATGAGCATTTCAAGTAGAATGTAT AGGGCTCCAGGGTTTAACACCCTTCCCA GAGCCTTTGATGCCATCTTTGTAGAAGCA CATGCCATTACAGAGAACAGCCAGCACC GATCTGGCATTCCTTGGATCCAATCTAGA TTAAGTGGCCTTACCTTCTGTGCCCTTAG GGCTCATGATGCTCATTGGCAAACATATT CTTCCACAGATGAGACTACCACCGCAAC TCTCTATTGCCAAAGGAGAAGCTGTGCC CTATCCATCAGAGTATTTCTGATATGTAA CTCTGGGCTCTGCTTGGTTCACCTCAAT CTCTTTTGTCAGTCATTTGGCCAATTACT GTCTACAGAGT ACATCCATAATGTTTTGTTCATGGCCTGC AGTGTAAACCTCTCCAGTCATTTGTCTTT TCATAAAATTTTATCCTCAAACCTATTTGT ACTTCTTTCTCCCTCAACCCATCCCATTT CCCCTAAACCTTTTACCAGGCTGTCTAAA ATATCCCTTTCATGGTAATAAACATTTAAA AAAATTAATTAATTTTGTAAAAGCCTACCT TGACCTCTTTACTAAGAATCCCCCTCCAT C I I I I I I ACGTAACTGGATTCTGGTTCCT CCTGGATATGAATTTCCCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS 10936274 3 163467122 CAAATCTTACTAATGGTATTCATAATTCTA A/T CTTTATATTATTTTAATATAGACTTCTTTAA SEQJ)124

TGAAGATTGATAAAAGGCTGGGCTTTTGT TAATACATGA I I I I I CCTGCCATAA I I I I I TTGTTTATTCCTGCTAATTACTCACCAGT ACTTCTGGTACCTTCAGTAGCATCCTGTG ATΠTCCTGATCTTTTATTCAAGCTTATTT AAAAGTCTGACCTAATACATATCCATTTC CTTTATGTTGGGGTCTGCCAATCTTATAA TCTGTCTAGCATAAGAATGACAGAGGCA TGTTCAAACCTGTTGTATGAAATGGAAAT AAGAAGAAATGAGAGATGAGATGAATGA

GATTTGCCTTCCTACTCGGAAAAA TGACTCA I I I I I CAATATCTTAGAA rs9832510 163472542 TCTTGGGAAAATATTTCAATGCAAAATGG C/G AGCAAAATGACCCAAGAGCTTGCCTTTAA SEQJ3125 CTCAATTGTCCTCAAAGTACAACTTTAAC AAAATACAAGAACTGAGTACAATCTGTAC GTCATTGTTCATAATCAGACCCGCTGCCA TGGTATTTCAGAACCACTGCTTTTAAGAA TATTACCTTATTTAAAATGCCTTTCAACAG TGTTGC I I I I I ATTTTAAATGTAAACCTCA GAATGATTTTAGCTGAAGAAGAACAATTT CATCAAATATACTTTCTGAAAGTTAGTAG TTAAAAATCTCCTAAAAAGCTCTTAATCA TCTGTTCAGAAGTGGAATTCTATAATCAT GTGAATCAGAAATCATGGGAATCAT GTCTTTATTTCATCTGAGTATTTTT rs11925201 163473903 AAATATTTTCTTATACGTATTTA I I I I I I G C/T CTTCTAGMTGGGAAGTAGAAAAATTTAT SEQ_0126 GAAAATAAGAATTTAAA I I I NATGATTCT GAGTACGTCAGAGAAATAAAATTTAACTG TATAACCCTAGACAAAATTTTAATTATATC AAAAATGACCTTCAAATAGACCTTTAGAG ATTAAGATCAAACTTCATGGAAAGTGATT AAAGTCTAAGTGGACAATAAGCAGGGTT CTCTCACAGAGAAAATGTGAAGACCAAT ATGTTAATTACCATATTTCTATTCAAATAA GAGTTTAAATATACATGTGTGCGTTGGTT GACTAATGAAACAGAACTTAAACTATGAG GGAGGGGGTGTGTGTGTGTGGATA A I I I I I IAAATTTCAACTTTTATGATAGGT TAAAGGGTATATTTGCAGGTTTGTTACAT GGGTAAATTGTGTGATTCTGAGGGTTGT GGTCCCAACAGTCTCATCACCCAGGCAG CAAGCATAATATCAACAGATCATTCTTCA GTGCAAGCCCCTCCCCCTCCCTCACCCT TCTAGTCATCCCCAGTGGCTATTTCTCCC ATCTTTCCATTTCTATGTATTCAACATTTA GCTCTCAGTTATAAGTGAGAACATGTGC CATTTGGTTTTCTGCTCTTAAGATGATTT GCTTAGGATAATGACCACTGGCTCCATT CACGGTTGCT rs12635341 163476410 TAATGGAAGAAACCATTGTGAAGGAAATT A/G CATTCATTTTCATAGTACCAAATTTCCTG SEQ_0127 TGTTCTTAGTACTGATCTCTATATAAATCA GATTAAGGTCAACTAAAAATCATTATGAG GATTATGATAATΠTATGAATCTCTATGTA GCCGCTACTATATAAAGAGTAATATATAA CCCTGTACTGTTTATCAGACATTGTATAG TGCAGTGCATAAACATTGTAAGAAAAAAT TGTAGCTTTCTGGAGCAGGTTGTGAAGA AAACCAAACTATATGATCTTGAGAATAAT GGTGACTTGTGACCTTGAGGGCTACAGA AATGTTGGAAAGTTCTGCACAAACGAATT AAGGAGTAAAGATAGTAACATCATTT TCTACTGGTTACCTACATAATATCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs16847030 3 163479855 GCAAGATGTGGCTTTGATTGTAAGTGAG A/G CACACTTGGAACCCAGAGTGAACTCTGA SEQ_0128

CCA I I 1 1 IAAAATCCTCATTATTTTAGGTT AATTCATCTAGAAACCTGCATCATTGAGC AGTACATGATCTCTTTCCTGAAGGTGAGC ATTTGAAATTAATCATCACGATGCACAAG AGACTCCAGAGGT GAGAGCATGCTGAG rs12638460 3 163492451 CCCAGGCTGGAGTGCAGTGGCGCGATC CΓΓ GAAAGAAGATGGTATGGCAATGTGGTTT SEQ_0129

TCGGCTCACTGCAAGTTCCACCTCCCAG CGATTTGCATCTCTCTGATAATTTATCAT GTTCACGCCATTCTCCAGCCTTAGCCTC GTGAAGCA I I I I I I CATATGTTTATTGGC CCGAGTAGCTGGGACTACAGGCACCTGC TGCTTGTATGTCTTCTTTTGAGAAGTGTC CACCACGGCCAGCA I I I I I I I I I l I I I I I 1 TGTTCATATATTTTGCTCA I I I I I GATGGG TTTGTA I I I I I AGTAGAGACAGGGTTTCA CATATTTGTTGTCAGCTCATTCAATCGTC CCTTGTTAGTCAGGATGGTCTCCATCTCC TAAGTTTCTATAGATTCTAGATATTAGAC TGTCCTCGTGATCCACCCTCCTTGGCCT CTTTATCAAATGCATAATTTGAGAATATTT CCCAAAGTGCTGGGATTACAGGCGTGAG TCTCCCATTCTTCAGGTTGTC I I I I I ACT CCACCGTGCCCGGCCGCAAGTGATCTTT CAGTTGATAGCTTC I I I I I I CTGTGCAGA GTTAGAACAATTTGTTTTCATTTGGATAC AGCTCTTTAGTTTAATTAGGTCCCACTTG ATACCCAGTAATGAGATCGCTGGGTCAA TCAATTTCTG I I I I I I I I I I CACAATTGTTT ATGGTAGTTCTGTTTTAAGTTATTTGAGA TTGAGGACTTAGTTATAAATTCTTTCCCA TATCTCCAAACTGCTTTCCACAGTGGCAA AAGCCGATGTTCAGAATGGTATTTCTTTG AACTCATTTACATTCCTACCAAAAATGTAT GTTTTCTTTTAGGA i I I I I ATAGTΓTTAGG AAGCATTTCCTTTTCTCCACAGCTTTGCC TCTTACATTTAAATCTACAATCCATCCTG AGCATCTGTCGTTTTCTGAC I I I I I AATAA GGGTCACTTTTGCATATGGTGAAAGGTAT TAGTCATTCTGAC TGT

ΓS6441443 3 163499147 TTCTCAACTGCATTTGCATAGTTCTTGTT C/T AGTGAAGAGTGAGTCTTTTGAAGCTTGTC SEQ_0130

GTGTCACCAACCAAGCCAGATTTCCTGG A I I I I I CCCAAACTGCTTCTTATATCCGC GGGCTGGAAAGTTGACTGGCTGACTACT TTCCATG I I I I I I I CTATTAGCACTACTCA GTGTATATCCACGGAGGACTTAAGACAG TTCCCAAGCTTATCTG I I I I I CTTATGTG

/^" AGGAGAAAATTACATCACTGGTTGAATCC CTTCTTTATTATTACCAATGAAAAATGACT ACAAATAAAATTTGAATTTCTCATGGAGA TAGTAATATTTCTTATGCATTCATAAAATA AGA I I I I I CCAAAGTGTAACATATGATTG TTCAAGTTTTGCTGCCATTAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3¹ Flanking Sequence SEQ ID rs7651936 3 163505661 GTTAGG I I I I I I CTGCCAGGGTTATTGGG A/C TCATATACACATGCCCCATTTTGTAACAT SEQ_0131

TTATTGAGGCATAATTGGAAAATAATGAT AGTTGAGGTACACTGAAAGCACTCTACT

TGTATATACTTAAGGTATTACAACATGAT CTGGGTTTCATATCCCAAGTGATACTTGG

GTTTTGGTGTACATCTATATATTACACATA ATGACTAGGAAAAAGTATTGCAGGCCAC

TATATGTGTGTATATATATGTGTGTGTGT CCTGCTCTGGAACCGAGGACAACAGAGG

GTATATATGTGTGTGTGTATATATATGTG AGGATGTTCCATAACATTACTCCTTATCT

TGTGTATTACCATAATTAACGTAATTAACA TAGGATACTGCA I I I I I GGCACATTCTAC

TCCATTGCAAGAATTCTTGACACAGGGG AGTTATTCTGACAACTACAAGCAGGATGA

ATCAAAGCAGACCCAGCTACCACAGTAT GGTAGAGAGCTGGGTCGAGGCCATTCA

TTATACCTCTACAACTTGCATTCTTAGGT GTGGCCTGTCCTCCTGCAATTCACCTCT

CTAGTTTGGTAAGAAAGAACACTCACTCC CATCTTTCATATTACACATATAAAAGTCA

AGTCTAGCAAAGCAACTTTATTATTCACA GTGTA I I I I I I CATGCACACTAACTTTCCT

ACAATCAACGGAAGTCTGGAATCCATGG CAGTCTGGAGGCAGAAGTTTGTCCCATC

CAAGCCAATTTCCCAAGGCTTAGAAGAG AGATTGATGTACACCTTGATTAATGCAAT

CTGCCCAAGATGGCTGGAGT CTCTTTGCAACATCATTGAGCCATAGGCA

GATGTATTTCACTAGGCCCATGAATATCA CTGCCATAAACAGGATGCTCAGGCCTGC CTGAAACAGTGAATAGCTCAGGATTCCA GTGATTCAGGTAGAAAGTGGCTAAACAG

ATAAATTGCTGAATGAATTAGAAAACAGA ^

CAAATAAATGTAATCCAAGTTTATGCTGC ∞

CTAGAAGAGTACATCAGGCTTACTAGAG ACCTACCAAGCCAAGTATAGTTCATTTAT GTCTTTTATGAGATCTTTGGTATTATACAT AGGAGTCAGTGATAAGTGATAAAAAAGC GATAAGAAATCTGTCCCTGTCCATGACA GGTATTACTTCCTCCACTGCCACTGCTTT GTCAGCTCAGCAGACATCCCTCAACTCC ATCAGGAAGAGTATTTTAAAGAACATAAT TGTTCTAGACTTTAATTGCTAGACAGAAT TGCTCCATCCAACTGGGAGGAGTGTGTG TAGTTGTCAGTACCTCCTGCTGGATCAAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS1844140 3 163528272 TTGGGAATTTTAGAATTTGAGAAATAGAA A/G AGGCAAACTTAACAAGGAGGTTAAAGAT SEQ 0132

AAGGAGACATTACCACTTCΠATTTGAGA ACAGGGATTGAAATGTATGCCCTGCAGT GAGAGCTTATTTGAGAAAAAATGACCTCA GCAGGGTATTACTTCTTTGGCACACTTTA AGCTCCCTAAATTTGAGGAATTAAATGGA CAGGCCCTGACTATCTGCTTGATAGTTTT CATAAAAAATAGAAAAGCTGAAAGAACTC GAAAAGGCCTGGTCCAGTAAATAATAATT TAGGACATATGCAAGGAAAACCACACTC TGGCCATCTGATGGGTGCTATCCATGCC AGATATTGTAATAAAACTGTCTATAGTAA TAAGTGAAAGGTTTGGTGAAGGGTTTTAA AAAAAAAAAATTGAAATCAACAAAGAAAA GTAATTTCATTTGGTTAGCTGCAGGCAAA AAGCCATCACATACAAGAAAATTTACATA AATA I I I I I CCTTCTTTCGTGGCTAGCCA CAAGAATCAGTGAATTTTTTAGCAGAAAT TCTGGAGGGGAGGAAACTATGTCTTCAT CTTGCAGGCCAGAAGGAAGTAGAAGATA GAGGTTCCTCATTCTATTTCTTCTCCTGA TATTAAGGTGCTGAAACAACAACAATCCC GTATTGGGGCTTGGTTTCCTGGAGGGGA TATCATCCAAGAATCTTGTATCCAGTAAA TTACCCCATACTAAGGGTCCTTCTGTAAG ACTGGTCTΠTAAAGTGAAAGAGGATTTA CATTTCTAATGGAGGGTCCTGCCTTGCG AGACTTTCCTCAATAAATAAAAGTTGAGA GCTCTTTTGTCTTCAATATCCGCTTGGCG AAGTGCCCTTCACTAAATCTTCTCTACAG GTTCCCTTCTATTTCCCTTTCCTTTCCTTT AAATACTGACGGAAATCCTCCAAGTTGAA CCGATGACCCCAGCAGTGTAAGACTGCC ATGAAGAAATGCTAGAAAGCAACACAAA ACCTCTTTAGGTTTCTGTACAGCCAATAA GCCAAAAGGAAATTTAAAGTTCAAGAGTA TAATCTCCTAATGGCTTCCTGATATTTGA AAAGTAAATATAAGAACAAACTTAGTAGC TAGGTGTTCCTTTGGAAGTTAGGAATTCC CTGTACAATTTCAATATCAATTCATAAAAT CTTTCTTTCTATATTGCTGCATGGGCATT TTTAATGACAAAAACTGTAAATCTATGCT GAGGACTAGGTAAGCATACTTAGAGTCT AGTTGGAAAACACAAACAAAGAATTTGTG GTATGTATATTTACCCTTTTCACTTCTCCT GCACTAATAACATAATGTGTGGGATGGA AATTCTAGTGCCCGAGTTAGGGCTATTA GCTGTGAAGTAGAGTTTTTGTATGAAATT GTTTTGCCAGCTGAGCGCTAGTTCCTGG GAATTGCAATTGCTATTAGTTTAAAAGAG AGTGAGTGGCTTACTTTCAAGTATTCCAT AATGGTGTAACTTTAGGATCTΠTGTGTA TATCACTGACCACTGCATACCCTGCTTTT ATTTTAATGGTAATCTCAAAGAAAATATCT CGAAGTCC I I I I I CTACAAAGGAACTTCC ACAGAATATATGCAAATAAAAATGAGAAG ATCAGTATAAAAGTTAAGGTTGGGATCAG AGAATCAAAGATTTTCACTATAAAAAGTT TCAAGGGAACCTCTAAAAGGTCCCTTCA ATTAATACACAAAAGATGACAGTTAAAGA AGTGGCATAGGTTTGAGCAATTACTTGTT GTCCAGAGAAACTAAAGCTAAAAGAAATA GACAGTTACGTTCTATCTTTTCTTCATTTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11917604 3 163541142 CAACATAAGCTCCATCAAGTTTAAGACAC C/T ACCTCTTGGTAGCCATTGCTTTGATTGTG SEQ_0133

TTTTGTAAGTGATGATACCAGCAATTTAG CTTTATCATTGGGATCATGCTAGTAAAGT TTCATCCCTAAAGAGATGAGCATCCTGG CTAGGATTTTGACCCCACTTGTTTAAATT GAATTTATCCATGTTAATTCATTC I l I H I TCAATTGGAAGCTTTGCTCTTGTCTGTGG ACATTATGCACTGAAGAGAAATGGTTGTC CTGACCTGACTACAACAGTTTGGCACTC CTTAAA I I I I I I I I I AATATTAGAAAACAA ATTGAGTGAAAAGTTTGCTCAACATCTAT GAAGTCAAAAAGAGCCAAATCAGGACTA TTTTCAGTAAGAATTGTGTAAGCTAAATC TGGGGAGGCTGACTAATGATTTCCCATG AATTGAGATGTCAGTAGTGTTGGCTATTG GAAACTTTAACAAAATTACCCTTGCTTGA TTTCTTCTGTTTATCATTGGTATGCTTCAT TGGGAGAAATGAGCAGGAACATTGTGAC TCAGGGCATGAACAAGACGACTTTTGTC GGCGGAGAGAGACTCTCTGATGAAGTTT CTTGCAAATTGATGTGGATGGTCTGCCA TCCTGGGTG I I I I I I I GCTAAMCTTTGG CTGTGGGCTTCATCTTCAATATCCTTTCA CTAACTTTCTCAAAACACTCTCATAACAA TCCATTCTTAAAATGTGTTATTCCTTTGTA GATGAGATGTTATCACTGTTTGTACCTCC AACCCCTGATTTCTTTTGGGCATTGTCTC AGAAAGACAACAAGGAAAATGGCTCAAT ^"ΠTAAACATTTTGTAAAACGTCAATGATTT AATTCCAAGAAACAGTTGCCATAATCTTT CACTATTCTTCCACCCAAGTTTTAACATA GCCCTTGACTGGTCCACTTTTGCTTTAAC AATTTAATGTTTGTTCTTGCTTTGATΠTA TAGAACAGTTT GCAGAA

ΓS7624911 3 165760782 GTTTGAAAAGGTGACTCTCAAATACTCTA A/C ATTTTAACTAAATA I I I I IAAAATAGATATT SEQ_0134

GAACTGCTACTGACTTTCTTTAAAGTGAT TTTGGTTAAAAAAGCATATGAAAAGCACA 00 GTCTTCTGATACATGAAGTCCTATGAAAG CAGTAGTTG I I I I I I GTTTAATTTATAAGA O TTTTCTTTCAATGTATGAGTTGTAGGACA TTTTATGAATAAATTTATAAATATTCACTTT ATGCATTCATACTCTATGAAAGGATGACA TTTCTTCCCTTCCCCTTTTCCCCTGCATC TTTTCACATAAGAAAGAGGTATACACATA ATTTTAAAAACACTAGACTATAATCCTΠT GGTAGTTACCCCTTCCTATACCTATCAAT GATCTAAATTATGTTGCCAATAGAAACAT A ATATATGTCA I I I I I CATTATATTTACAAC CTGGTTTCCTATGACTCGTTCTGCTGTCT CTAGG rs6775672 3 165762840 I I I I I ATTTTGGTTTATTTAGTTTTATTCTT C/G TTAGATAAAATCTCAAATATCCCAATATAT SEQ_0135

TCAATATTC I I I I I GAACATGGTGACCCA TTATTACTAACATGCTTTCTTCAGCCTCTA AGCTGATTGCAATATTCTACATCGTAGTA TATTTAC I I I I I I AGGGTAA I I I I I I I I I I A CAAACAACAAAAAGATATTAACTTAGTCT A I I I I I GTTTCTC I i I I I GTTGTTTTGCTTT TTCTGCATTACTGTCATATAATTTCATTAT TTGGTGTCTAGGTATATGGTAACTAGTAA TTTGTTTTATATTGAA I I I I I I I CTCAGGA GCAATAGGAAATGATCCACAACATTCAGA ACATTCTATGCTTTACCTGCTA TGCGTGGTTAATTTCCTTTACTTTCTTTCT CAAATTAAATTCATTTCGGGGACCCACTG GCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9868892 3 165773791 TACCCGATAACTCAAATTTGCCTTTATTC C/T TTCTCTTCAA I I I I I Π ATATTCCATCTAA SEQ_0136

TAATGTGACACATAAATAAAATCACAATT ATGCTTTGCTGGCTCAGAATTTCTTGCTT CCTTAGTTTAGCTTTTAAAGACTTCTGTAT TTATATCCTCCTTAAATCCTATGGACCTA TTCCCAAATTTATAGCTTTATACTTTGTCA TTAAAATCCAAACAAATACAATGACCATC TGTATTTGTTTAATATTGGTTGATCAATAA ACTCTCACAACATGTTATCTGGGGAAAAT CTATATAAAGTTTTGGGTCAGATTTGCAG ATTTTCTGCATCCTGCACACTCTTACAAA AGGACCCAGAAAACCTTCCATTG TATCACAGATCTCTATACTATTGTT rs9290240 3 165780254 AAGTTATTTGATCATAAACAAACAACACA CfT GTTCCAATTTATGTTAAATGATGTCCTCC SEQ_0137

TTTGATTTAAAATGAAAATCTGACATCCA AGTGTCTCCTGTGGAGAAGTTGCTTTGC ATTTGCAACCTTCTGTGAGCTAATACATT TGATGGCAAGTTCATATCACCCGTATCTC ACCAGATAAATCAATTCTATCATTGAATT TAGGGGAAGTAGTTCAGTATGGTGATGC GAATAGCAATTATAAGAATGTGGTTAAGT ATTAAAGGAAAATTAAAATTAAATTTCAGT CAGCCAATTCAGTTGTATTTGGTGAAGCA TGTCTTATAATAGCTTTTTATAATTATTTG ATTTATGGTATTGCCCATAAATGTGA ACAACCTAGTTAACACCACCAACATA rs9815560 165805885 CATATAAGGAAAGGGCCCAGCTGTAATC A/G TGGTGTTTATGTGTGATTTCAAAAATCTT SEQ_0138 AATCAAGCTGTTTTTGTGTGTTTCTTTCTT ATTATATTGTCAAGTTACATTGTTAAAGA TTTCTATCTATAAATATGACCTGCTCACAT GCTTTATTTAATTGGCTTTAAAAATAGATA TAGTGGGTCGAGCGCTCTGAACTTCAGC CACTAATTGTTCTTTCAGAAAAATAATTAC TGGTTCAAGCTTCTACCTAATTCATGAAT TAACCCAAATTC I I I I I AAGTTCACATGA

00 CATTCTGGGATCACATAAACTCTACTAAA CTTAGGTGATCTTTGATCAATAAAAATATT TTTATTTATCTAAAGTCTTGTAACAGTTTG GTTGGTGTAATGCAAGCAGGCATGTCAT GTGTGTCAGTATTTAGATCCAATGTAGAC CAGAGTTGTCAGCATTAAGTATGATGCA CTCCATCAACCCTAGGAGCATCAAGTGA GACCAATAAGTTGTATCTTTATTAGATGT CCAAGCAAAGGTAACCTCCAGGGATCAT TTAAAATAATAAAACTATAATTTCAAGTTA TGTGTCCATTAATCTCTTACAGCAATTAG AGAACAAATGGGCAAGCTGAAGTATAAT GGTTATGGGTGAGTTCTCTCTCATATTAG ATCCATTATTTCATATATATCAAGGACAG AGCTTCCCAATTTTGTGTGTTAGGCTCTC CAACTAAACATGAAAAAAATCTTGTTTCT CAGCTTTTCACGACTGAGTCTACTTAATT AGCTCTTTAGGTTCATTACTTTTGTGATG ATCAGATCCAATCTGGATGTTTTCATCAA ACTATATAAGATGCATATGCAGTAAAAGT TTAGTAAGTTTTGTAGTATTGTACTGGAC AATTAGCAAGGAAATAACTTGGGTGCCAT ACATG I I I I I I I AATATGTCTGTCTATGTC GCTTTGTTTTGGGTTATGACACGTGTACT TGAATGT TAAAAA

Supplementary Table 3

SNP Chr Position 5' Ranking Sequence SNP Base 3' Flanking Sequence rs10154905 3 165808082 CACATTCATGAATTGTGACATGACTCAAT C/T GTAACTGAATGTTAGCTATATCATGATAA

ATTGCCAGGCTTTAAAGCATGTTGCCCA ACTTAAATCCTTACATGCTATTAGAGATT GTTATATTTTCACCAGGTAAAAGCCCTTC ATTTGGTTTATCCTGTAACAAATTTTACTG ATGACCCAACAACAATCTAACCATGTACA ATATTCCAAGTGGAATGCGTGTTTTCTTC ACCTAGAACCTGAAGATTGGGTCTTTGG TATAGGATTACACTTTCTATAGATTACACT AAATTATACCACAAAAAGACTGCTTTCGA TTTAGTTTCAGGCATTCAGATGCAGTAGG AGTTTGTTGGAAGAGACCATACCAAGTTC AAAAACGTATAATGAGGGTTTTAC TACCCACATGGCAGTATAACTTAAGGGT CTCGAGGCTTAGATCCACTTTTCTCAATC TAACAGAACCCCTTCAGAATCTTGGGACT GTAAACCCACTGAAGACCCCAAGGTAAA ACTAACAAGAGTGG I I I I I CCTCAAAACC AGGTAACAGCCTAGACAGCTTTCCTAAG ATTACAGATCAAGAATTCTGTCCTCTGCC ATCATAAAATCTCTTTCCCCTGTCTTCTTT GCCTGTTTCTTTTCCGTTTATGTATGGCA AGATAATTAAGATTTCCTAATCAATAGCTT CCACAGGAAA rs6804759 3 165810387 TTCTCTC AAG AAC G CATCTTAAATATACA A/G AAGATGTTATCAATGCAGTAAAAACCTAT SEQ_0140

AAAATTTCAAAAGAAACATAATGCAAGAT CCTAGAGAATGGCAGAATATATCTTGCAT

TGCAATAATGCTTTCCTTAATATCTGGGT ATATCTGATAAAGGATTGATATCCAGGAT K*

TAAAAAAATATGTCATGACGAAATΠTTG GTATAAAGAACTCCTACAACTAAACAACA

GCCACATTTATCTTAAACACTAGGATTTT AACAACCCAATTTAAAAAGATAGGCAAAG

TAATTTAATTGAAAACTGTGTTACTTAAGA AATTTGAATAAACATTTCTCCAAAGAAGA

ATTTCCCTACCATTAACTTTCAAAATCAGT TATACAAATGGCCAATAAGCACATAAAAG

GATCGCTGGGGAGTAGGAGAATCAGATT ATGCCCAACATATTAGTTATTAGGGACAC

TCCAGAGTTACTACATTAAAACCTCTTCA ACAGATCAATATTATAATATTACTTTATAC

ACAAATAATGCTCGGCAAACTAGATATAC CTACAACAGTGGTTATTAAAAAAAGAATA

ACATGCAAAAGAATGAAGTTGGACCCTTA CAATAAGTGTTGGCAAAGATGTAGGGAA

CATTGTACCTATAAAAGTAGCAACTAAAG CTGAAAACCTTGTGTATTGCTAGTGGGAA

AGAACAATAGACCTAAACTTAAGAGTTAA CGTGAAATATTGCAGCCTCTGTGAAAAAC

CACTATAAAACTCTTAGAAGAAAATATGG AGTTCAGCAGTTCCTCAAAAATTAAATTA

GGAAAAGCTTCACTGCATTGAGTTCGGC AATGATTACCTTTTAAAGGTAGTGCTTAA

AATGTTTTCTTGGATGTGACACCAAAAAC CAACATGATGAAGCCTCAGAGTCCTATG

ACATAGAAAAGCAAAAATAATAAATCGGA CCACAGTAATAATTATAGCCAAAGATTTT

TTTAAATTAAAAAATTCATGTGCATCA AAGTTATTAAGTATATTTGATAATAGCTG GTAATATTACGTATGTTAAAGTAGTGAAA AAATTCCACATAAAATATTA I I I I I GAGCC AGTTCACATCAGTATCTTGGGAATATGAA CCTAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1913297 3 165810690 TTCTCTCAAGAACGCATCTTAAATATACA A/G GCAAAGATGTAGGGAACTGAAAACCTTG SEQ_0141

AAAATTTCAAAAGAAACATAATGCAAGAT TGTATTGCTAGTGGGAACGTGAAATATTG

TGCAATAATGCTTTCCTTAATATCTGGGT CAGCCTCTGTGAAAAACAGTTCAGCAGT

TAAAAAAATATGTCATGACGAAATTTTTG TCCTCAAAAATTAAATTAAATGATTACCTT

GCCACATTTATCTTAAACACTAGGATTTT TTAAAGGTAGTGCTTAACAACATGATGAA

TAATTTAATTGAAAACTGTGTTACTTAAGA GCCTCAGAGTCCTATGCCACAGTAATAAT

ATTTCCCTACCATTAACTTTCAAAATCAGT TATAGCCAAAGATTTTAAGTTATTAAGTAT

GATCGCTGGGGAGTAGGAGAATCAGATT ATTTGATAATAGCTGGTAATATTACGTAT

TCCAGAGTTACTACATTAAAACCTCTTCA GTTAAAGTAGTGAAAAAATTCCACATAAA

ACAAATAATGCTCGGCAAACTAGATATAC ATATTATTTTTGAGCCAGTTCACATCAGT

ACATGCAAAAGAATGAAGTTGGACCCTTA ATCTTGGGAATATGAACCTAAAA

CATTGTACCTATAAAAGTAGCAACTAAAG

AGAACAATAGACCTAAACTTAAGAGTTAA

CACTATAAAACTCTTAGAAGAAAATATGG

GGAAAAGCTTCACTGCATTGAGTTCGGC

AATGTTTTCTTGGATGTGACACCAAAAAC

ACATAGAAAAGCAAAAATAATAAATCGGA

TTTAAATTAAAAAATTCATGTGCATCAGAA

GATGTTATCAATGCAGTAAAAACCTATCC

TAGAGAATGGCAGAATATATCTTGCATAT £

ATCTGATAAAGGATTGATATCCAGGATGT ^W

ATAAAGAACTCCTACAACTAAACAACAAA

CAACCCAATTTAAAAAGATAGGCAAAGAA

TTTGAATAAACATTTCTCCAAAGAAGATA

TACAAATGGCCAATAAGCACATAAAAGAT

GCCCAACATATTAGTTATTAGGGACACAC

AGATCAATATTATAATATTACTTTATACCT

ACAACAGTGGTTATTAAAAAAAGAATACA

ATAAGTGTT rs9290241 3 165816365 TAGAAAAATGTCTAGATTTTATTTATTGAT C/G GAACCCTGCTTTGATCAC I I I I I GGCTAA SEQ_0142

ATCCTCCCCCTCCCTCAAATTATGCTGTA ATTGGAGAATTCATTAAGTGTTTAGATCT

TGTATGAATATTTATCCTCATTACTCCAGT CAGTTAATGTGTAGGAAAAAATGTCTTTC

GTAACTATGCACTTGTATTTTCTTCCATTC TTTTAGGTTTGCAGAGTAGCTTAGACATA

TTTAGAAATCACCAGATCTACTCCTTGGA TAATGTTTAAATCTGTGTATAATTCTAGCC

TGATAAAGCAATGCAAATTGCAGAAATTA ACAAAATCTGTGATCAGAAAATATATTTC

GAGGTGAAATCAAATGGTTGAAA C I I I I I CTTCTTTATTGATAACAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7625485 3 165822669 TTACTATTGTAAATAAAAAAGCATGAAAG A/G GAAGAAAAATACACATAGTGAAAATCTGG SEQ_0143

ACAAACTTCAATGAATAAAATAGTTAATAA TAAGTATAAATTTTAATAATAAAGAAAGAG AGTTTAGATATAACTTCAATTTAATCAGCA ATTTGCACACAACCAGCCTGTAAAAACAA AATTATAAGAGCAGCTAGCAAAATTCTTT AAAACAAAACCCCAAAACAAACAAAAAAG CAAATACTAGATATTATTTCTTTAAGCTGA CCACCCAAAACAGTAACAACAATGTATTA AGGAAATACAACTACATTCAAAAAGCTAG TCTTTATTTCCAAAGAAGAAAACAATCAA CCAGTTATTAGGTAAAATTTCTT TGTACATCTCAACTTCCCTGTGAAA

ΓS1478007 165823065 AGTATAAATTTTAATAATAAAGAAAGAGAT A/G TTGTGAAGAAAAATAAAAGTATTTTCTCAT SEQ_0144 TTGCACACAACCAGCCTGTAAAAACAAAA TTTATTTCATATATAAGAAATTGCTTAAAA AACAAAACCCCAAAACAAACAAAAAAGCC GATAGAATGTTATCACTGATGATTAAAAT ACCCAAAACAGTAACAACAATGTATTATC AGAAAATGAAGAATAATATTTTAGCAACT TTTATTTCCAAAGAAGAAAACAATCAATG TTAAGAATAGCAAAATATGTATGTAGAAT TACATCTCAACTTCCCTGTGAAATAGATA GTATGAGAAGTATTTAAAAATATATTCAAA AAAGGCTGATGATAAGCAAATAAAGCAAA TAAATTATGATCTATAGAGACATAGATAA ACAACATACAAAATAACATAATTGCTGTT ACTAATGAAAATCAGAAGGTGTAAAAAAA AAGAGTTAGACACATGTCAAATAAAATTT AGACATTCTACACACTATGATACAAGTAA GGAAAAAAGGCAGTAAAGTAAAAATAATT CATC AACAATAAAATTAAATATTCAAAACAATAA GCATCTAAAAATTTCAGATTGTAGAAATA AACTGTAGAAAGAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6785579 3 165827449 AGCTCAGCCTATTTACTCAAGAAGAAAAA A/C CACCCACTCACTCTGCAGCCTACAGATG SEQ_0145

ATTTCATAGAAATGTACATGGAGTAAGTA AGATCCGGCGACAACTGAGAAAAAGCTG

GAAAATGTTGGAAACTATTTTAGGTTGAA ACAGAAAGGTAAGAA I I I I I ACCCAGGTC

TTGCATCTCTCCAAAATTTATATGTTACC AGCCCTCCCAGATCTCTGATAGTGGTGT

GTCCTAAATCCTAGTACCTTTGTCCTGAG CCAGTTGAAACAGAAAATTTCTTCTTTCC

ACAGAGTATTTCAAGAGATAATTCAGTTA CTTCCTTACCAAATTCAGAGTAGCAGGAT

AAATGAAATCATTAGGCTTGGCCCTAGTT AAAATCATTTGTTTGAAAGGTCACTCTTG

CGGTAGGAATGATGTACTTATAAGAAGG

GGAAATTTGGACACATACACACACAGAG

GAAAGATAGCGTGAAGACGCAGGGAGAA

GACCACTATCTGCCAGTGATTGGATTCA

GGACATGCTACCCCATAATATGGTACTTT

GGCATTTGGGAAAACAGTGGAAGCAGTA

AGATACATTCACCTTCTCTTCATTC I I I I I

CCTGAAGCAACCCATAAAACCTAGGAGG

GTCGCTCTCCGATCTTCTCTTTTCCTTCT

TCCCTGAAAACCTTCATGTGGCAGGTGT

CCTGCCCTACCTAGGGGAAAGGAATGAC

ACACAGTGATGCTAAGAAGAATCTGAAC

AAACAGGCTTTGCCAATTTATTACCAATA £

GATCGTACCCTTCTGTCCTCCAATCCTAT <^■"

CTCTGCACATCCGTCTATAAAAATACACA

TATTTCTCCA I I I I I I I GAGTCTTCATTTT

GATGGCTCCCATGTCATATAAAATTGATA

TTAAATAAATTTGTATGCTTTTCTCTGGTT

AATCTGCCTTTTGTTATGGGGGTGTCAG

CCATCAGCCTTGTGATTGGTGAGGAAAA

GATATTATTTTTATCCCCGACGGTTTCTG

GTACCCAAACCGGGGAAGCTCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6764888 3 165830263 TCCTGTCTCTTCTAAACATGGTAGTTATC C/T TTTCAGACATATAGAGACTAACCCAAGTT SEQJ) 146

TTTTGGGAATTAAAAACTTCAGGAGATTA TTTTG I I I I I I I I I I I AACTTGACCTAATAT

CTGTCTCTCACACACACACACACACACA GAAATAAACTTTGATAGATAAAACTAGTT

CACACACACACACACACACACACAGTTT TAAATATTACTGGTAAAATAAAAACAAGA

GGAAATTGGGCAAATGAAAAAGTTTAAAA ATGTGTTAATAATTGTCATTAAATACAATG

GTCTTTTCCAGAAATAATAAAATG I I I I I I CAAATATACA I I I I I I I CTACCCAGGTTTA

CCATGTAAGCAGGTAATCTTAAGTTGTCC CTAGTCAAACATGCCTACGCTATCTCTAC

CA I I I I I GTCAGAAATGAAATTTGATAAAA CAGATGTTTAAGGTTACAAAACTATAATT

ATGTAAGTTGAGATTAGCCAGTGAGCTC ACAACCTAAGAGCAAATATGCAATAAAAA

ATATTTCCATGTTTTACTGACTCACGACT TGAATTGACTGATGAATAGAAGTTTAAAA

AAAATTTTAAAATGGAAGCTATGATATTT AAAGGGAGGGAGGGGGAAAACCATGTTT

GTATCTGTCTGTATATTTGTATATG I I I I I AACTTCCTTTGCTTCTGTGATATTTGTGA

GTATTTATGTTTGTAGGTTATTTCTGTGT TACTTGCTTGACTTGTCTACTAGAAAAAC

GTGATCTTCTCTACCACTTGATGGTATTA AAG TTAATTTATAGAATCACATAAATAAGTTCT ACTAGAATTTGCTTAGAGATAAATGAGTG CTTATGTAAATTAAGTATTCCTAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs6802624 3 165834641 ATGCAATAAAAATGAATTGACTGATGAAT A/G TTTAATATGGTTCCGGAAAGAAAAAATAT SEQ_0147

AGMGTTTAAAAAAAGGGAGGGAGGGGG GTTTTATGAAAAACTATAACAAACTCTTGT AAAACCATGTTTAACTTCCTTTGCTTCTG GGGCATTAGATCCTCATTCTGTTTATTCT TGATATTTGTGATACTTGCTTGACTTGTC TTTGGAGGTTTTGTTATTTACCTATGATCT TACTAGAAAAACAAGATAACAGTTAGCTT GAACTGAATCCTGAATTCTTCTAGTTTTC TGACTAGTGTCTAATGGAATTTTGATGAA TTTCATATCTGGTTACAACTACACAAATTA GAATTCAATCATAATTGTTAAGAACAAGG ATAATACTTTCAA I I I I I CTCCAATCCTTC GTATTAAATAGAATATAACTGGGATAAAT TTGGTTGAAATCCTTAAAATTATAACTTG GTTTATAAATAAACTTTTCACATATCATTA CCTATTTCTGAAGCCCTGCAAGTAAAACT TGTTTATAAGTAGTTGAAAAATC I I I I I GG GGATATCTCTATATAGACTTCAGATAAAT TAACTGTAATCCTAATGTTATGCTAAGTT CTACAATACCTTATACATGGACAAACTTC AAATTAAGTAATAGGTAATAATTCAATGT GTCCTGTCACTCAGGAAGCCCATCAAAA CTGGGTCACTTCAGTTCTATGTAGTACTG CACCCAAGGCTAACTGTATTCCAGGAAA AAACATTAACTGCTGAACCTGAGTTTATC ACCTGTCAAATTGCCGTTGCCTGACTTCA TGCTTTTGGGCTCTTAAATTGTATAGAAA CTCTACCTGAGATGTTTAGAGCTCAACTT GATAAAATATGTTGAGTCTGTTAATAAAC CTAGAAATCTCAACTGGCTACCCTCTAAA ATGAAAAATTATACTATGAAGAAGGACGT CTCACAAACTGAATTTATAGTTTGTTCTAA GTTTCTACAAATTATGAAATAGTGTTCAT CCATTAATATTTGCTTTTCTTTTCTTTCCA CTATACATTGTTGGTATAATAAGTAACAG TCAGAATGCCTCTTGTTAAATACTTAACT TTTCTTACTTTTCAGTTTTCACTGGAAATT GATAATTACCACTTAGAAACCTAACTTTC 00 AAGGTTACTAAAGGTTAAAAATTATAATTA GTGGGAGCCCACCTGCAACACTACCTTC ATATATAGAATTAAAACCACTGCAAATTAT TTAAATGAGACACATCTGTTAACCGTCCA AAAGGAGACAATTATATATGCTAAATGTG ACTGGACGGAGACACTAGTTCAATGTTTT TAAGAAAAATGAGATACATTTTTGACAAG ATGGGATAATCCACAAAGTAGTCTCTGG AGAAGTTATAAGTCATGAGGA I I I I I I I I ACTGTGAAACTTCTTTGGGAAGTGTTATA GTTGTTGTTAAGAGAAAAAGGAATAATTC CAGGA TGGATTTGTATTAGGGTTCTCTGGAGGG ACAGAACTAATAGTATAGATGTATATATA AAGGAGAGTTTATTAAAGGGGAGTATTG ACTCACACAATCACAAGGTGAGGTCCTA CAATAGGTCGCAAGCTGAGGAGCAAGGA AGCCAGTTCGAGTCCCAAAGCTGAGGAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 11922371 3 165835110 ATAAATTTTACCCTAATTA I I I I I GAAAAA A/C ACAAACTGAATTTATAGTTTGTTCTAACC SEQ_0148

AGTTTAATATGGTTCCGGAMGAAAAAAT ATTAATATTTGCTTTTCTTTTCTTTCCATC ATGTTTTATGAAAAACTATAACAAACTCTT AGAATGCCTCTTGTTAAATACTTAACTGA GTGGGCATTAGATCCTCATTCTGTTTATT TAATTACCACTTAGAAACCTAACTTTCGT CTTTTGGAGGTTTTGTTATTTACCTATGAT GGGAGCCCACCTGCAACACTACCTTCTT CTGAACTGAATCCTGMTTCTTCTAGTTT AAATGAGACACATCTGTTAACCGTCCAAC TCTTTCATATCTGGTTACAACTACACAAA TGGACGGAGACACTAGTTCAATGTTTTAT TTAATAATACTTTCAA I I I I I CTCCAATCC GGGATAATCCACAAAGTAGTCTCTGGAC TTCTTGGTTGAAATCCTTAAAATTATAACT TGTGAAACTTCTTTGGGAAGTGTTATACA TGCCTATTTCTGAAGCCCTGCAAGTAAAA GGAGGATAACGGGGTTCATGACAAGCTA CTGGATATCTCTATATAGACTTCAGATAA ACCCAACACATGTCATCTTGCCATCTAAG ATCTACAATACCTTATACATGGACAAACT AAGACAGCAGAAGGAGGAAGTCCATAGC TCGTCCTGTCACTCAGGAAGCCCATCAA CACCTTCTTCTTGCCTTTTCTTGAAGCAA AACACCCAAGGCTAACTGTATTCCAGGA GCCATATAACCTAGGTCACTCTGACTTTC AAACCTGTCAAATTGCCGTTGCCTGACTT TCCCTGTCTTCTCCCCTGATAACCCTCAC CACTCTACCTGAGATGTTTAGAGCTCAAC CGTGTTAAAAATGACAAAAGTCCTGACCT TTCTAGAAATCTCAACTGGCTACCCTCTA ATACCCACAGGAAAGGAATGTCCATCTA AACT GGGATGCCAAG rs9835555 3 165837660 ATTGTGGGGATGCTTTATCAGCAGAGAG A/G AATCAAAATCAAAGTTTGATGGA I I I I I I I SEQ_0149

TGTCTGTTTTGTGATAGCCAATGAAAACA TATTG I I I I I AATAGAGAAAAAATCCATTA 00 CAACAAACGTCTAATATAAAACGGTTATC GGAAACTAGCACCTTATTTATATGATACA 90 ACTAATTAATGCAATGAATAAAGGAAATA TACTGTATAACTTGCCACTTTTGTGACAT ACTTTTCCATTTAACATTAATTCACTAAGC AGTTTCTACAAAAATCCCAAACGACTAGT AGTTGCTAAGGAGTTTCTATTCACACAGA CAAGCTCTCATTAA I I I I I IAAATTGTTTT TATATCAAAGATGTGTATCTCGTATA TACTTCTTATGTACGCAGCTGAA rs9858061 165842402 CCACTCATTGCCCAGCACATGTGTTAAGT GfT CTGATAAAAAGCCCCACTCCTTAGTGTTG SEQ_0150 AATGA I I I I IATGCATAAGTCTTCCTATCC AGGCAAAAACAGCAGTTGATGAGCAAAG TGCTTAGGCTGATTCAAAATATTAAGAGG AGCACCCTTTCCTGTGGAGTTTAAATTAA CTTTACAC I I I I I CTGTCTTGGCAATATCT ACTCGGATTTGTTTCAGCAGGGCCTTAAT CTGCAGCAATTCTGGATCATGACCCGGA AGAAGCTCTATGATTGGGATGCTTTGGC CTGTTGAAAACCATAAAAATAAAAAATAT TTAGCTGATATCTCCATATGCTTTTGCTA ATATAGATAACCATTTCATTTTATACAGTT TGTCGAAGCCCATTTAATCATTTCGTAC TTGTGGAGGAGCAGGTG rs9829997 165844030 ATACATTAGGTTAGAAGAAAGAAGAGTCT A/G ATATGGAGGGAAAGACAACCAGACATGA SEQ_0151 TCCAAGTGGTAGAGTTGATCATTTTAAAA AATAATCGTTCTTTGTGAAAATAGAATAAT GTAGTCAAGCAAGTAATCCTCCTAAGAGT AGGAAGGATTAGGTAGAATTTTAGTGAAT AAAAGTATTCATTCCACCAAACTGGGATG GATCTTTTCTTAGTGCGTCCTTCTATCTA GTGGGGTGGGGGTGGCTGGGGGGAAAG ATATACTTCTCTCTTGATTCATATGGTAGT AAAATTAAAGAGTATTCTGTAAGGAATAC GATAGATTTCTATGAACAATGCCTTTGAG ATTATTTCTAGTGATAACTATTTTCTTA CAGGGTGTAAATAACCTTAAGCTGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1495046 3 165844409 ATGAACAATGCCTTTGAGCAGGGTGTAA A/G TAACAAATCGCCACAAACTTAGTAGCTTA SEQ_0152

ATAACCTTAAGCTGATTTTCTGAATACAT AAAACAGCACAAATGTATGAATATTTGGG CTCCAAATTGATAACAAAAACCACAATCT GCATCTTACAGTTCTGGAGGTTAGAAGT TTGAAGCCAAGTTGTTTGCAAAACCTGAG CTGGATGGGTCTTACTGGGCTAAAATCA CATTTTGAGATACATACATGCATACACAT AGGTGTCACCGGGCTGTTTTCTTCCTGG AATTATCTTAAAAAATTACCCACTTCTATC AAGCCCTATGAGATGGTCTGTTTTCTTGC AAAATGTAATCATTGGTAAAGCCTTTTATT CTTTTCTAGCTTCTAGAGGCTGCCTACCT TGTTTTCTATTACTATC TCCTTAGCTTGCATTTGGATTTGAAGCAC GTCTATCCCTGGTGCAACCGTTTGTAATA GTGTTTCAGGGTTTGGTTCACCTTCTGTT TCAGAATTAATCAAGTTTATTTCATTACCT TTAATTTTCCATTCTTCGCAGC I I I I I I AT TTTTATTCTTGCCTCTGTTATGAATATTTT ATAGCTAAATGATAAACTTAAGTGAAAGA AAGAC

ΓS11925107 165848150 ATAATATGTCTTCAGCCTATATTTCCAGC A/G GAGATTATATATGTATATGACTAGCATAC SEQ_0153 TTGATTTCATGTAATTCCTTGCTTTGTACT TACCTGGAATAGAATCACAGTCAAAACAT TTAAACTTCTGCAATAATAGTTCTAATATT GTTTATTTGATTAGATTGGATCTAGTTTAA CTTCATTAGACCATATAGGCTTCTCTTGT ATCAAATTACTATAATTAATATAGACATAT AACACATTTGCTTATTGCTGCACTTGACG AATTTATATAAATATATTGATATAAAGAAA TACAGAAGGTCACATAATTATTTATTTTCT TACCTGAGACTGGGTAATTTAGAAAAAAA ATCAATCTGTAAATTCTTTGAAC ACAAAAAACACAAAAACAGGTTTCATTGG CTGATATGGTTTGGCTGTGTCCCAACAC AAAGTCTCATCTTGATTTGTAATCCCCTT ATATTAGGGTTCTAAAGCGGGACAGAGA TAATATGATAGATAGATACCTATATAAAAA GGGGAATTTATTAAGTAGTATTAACTCAA ACAATCACAAGAGCTGAGGAGCAAGGAA ACCGGTCTGAGTCCCAAAGCTGAAGAAC CTGGAGTTCGATGTTTGATCGCAGGAAG

^■ CATCCAGCACAGGAGAAAGATGTAGGCT GGAAGGCTAAGCCAGTCTAGGCTΠTCA TGTTΠTCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1390044 3 165852108 TTCTTTGAACGGAGATTATATATGTATAT A/G AAGATAACAACTCCGTCTTCAGAACTGAG SEQ_0154

GACTAGCATACTACCTGGAATAGAATCAC GTAGCCTGCAAGTAGCACTAATGTTTACA

AGTCAAAACATGTTTATTTGATTAGATTG ACCAGACCTTGAGGGATAGGTAGGATTT

GATCTAGTTTAAATCAAATTACTATAATTA TAGTTGTTCTACGGTTAAAAAGAGAATAT

ATATAGACATATAATTTATATAAATATATT TCCAAAAATGAAAATCACCTGAACAAAGA

GATATAAAGAAATACCTGAGACTGGGTAA CATAGAGGTAAAGTAGGTGACATGGTGG

TTTAGAAAAAAAACAAAAAACACAAAAAC CAGGACTATTTATGGTCTGTATTGCGGG

AGGTTTCATTGGCTGATATGGTTTGGCTG

TGTCCCAACACAAAGTCTCATCTTGATTT

GTAATCCCCTTATATTAGGGTTCTAAAGC

GGGACAGAGATAATATGATAGATAGATA

CCTATATAAAAAGGGGAATTTATTAAGTA

GTATTAACTCAAACAATCACAAGAGCTGA

GGAGCAAGGAAACCGGTCTGAGTCCCAA

AGCTGAAGAACCTGGAGTTCGATGTTTG

ATCGCAGGAAGCATCCAGCACAGGAGAA

AGATGTAGGCTGGAAGGCTAAGCCAGTC

TAGGCTTTTCATG I I I I I CTGCCTGCTTT

ATATTCTCTGGCAGCTGATTAGATGGTGC

CCACTCAGATTATGGGTGGTGATACTAA £

GGCCACTGCTGCTTCCTCAGGGAATGCA O

GGATTAATCTCCTCTGACAAAGGTGGAA

AGGCTGATGGCAGCCTGGGTTGGGGAG

GGGATGTTGCCACCACTGGGGATAAGGA

GGCCGTTTCCTCTGGCAAAAAAGGCTAA

ACAGAATTTAGGAGCTTGGTGTCTTCAG

CTTCATCAGGGACCTCCCACACATCCCC

ATCACAGATTACAGGGTCCCA I I I I I I I C

CCCAAGCAATGTTCTC I I I I I AACAGTAG

CCACCTAGTGAGGCTGAGCATTCACCTG

ATATGGTTTGGCTGTGTCTCCACCCAAAT

CTCATCTTGAATTCCCATATGTTGTGGAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1874069 4 59216675 GGCAGGCTGGATGCTATTTATAGAGACT A/G ATGTCATGTGGATGTAAGC I I I I I CCAGT SEQ 0155

TATCAAMTGACATCTCAGTTCAGACCTG CCACTGAAAAAGCCAGATGTGCTATCATT TAGTAAATGAGAAGCCACGAGGTATTCA ACCCCACAGCAAAACATTCATATCCCTG GGGAAGAATGTTTTAGATGAAAGGAACA GCTTCATTGTACCTCTTGCCTAAACTGTG GCGAGTGCAGAAACTCTAGGGCAAGAGT CTGGATAAACAGCCAAACATTTACTGTCC GTGCAGGGAGACCATCATAGCTGAAGCA CCTTGTCAAGTTCTTTGCTGTTCATGAGT AAATGGACAAGAAACTGGTAGAGAATGA TTTACTTTATCTATCTCACTTTACTTAAAA GGAAACATTGGTAACAAAGCAGCCAGGT TTACTTACTTTAAAGTTTCATTTTACTTAT TTAAAAGGGGCTTGTATGCTACTGTAAAG CTTTAATAATTTGACTATGCCATTTAAAAG AATGTTGGC I I I I I ACGGAGTAAGATGAG CA AAACCACTGAAGGGTTATTGCAGAGGAA TGATACGATCTAACATACATTTTAAAAGG ACAGCTCCGGTGGCTGCATTAAGAATAA CCTGAGCCAATCTAGAAGTTGTGATGATA CTACTGGCTTGGACTAGAATAATGCAGG TAGAAGGGATGAAAACCGGTTTGCTGAT GGTTTGCATGTGGCATGTGCGGGAAACG GAGGAATCAAGGATGTCAT rs7663551 59242656 ATGATGAATAATA I I I I I AATGTATTGTTG A/G GTTCCCCTTTGGGTGTGTCTAGAAATGTC SEQ_0156 AATTTGATTTGCTAATATTTTGTTGAGAAT ATCTGGGAGCTAGGGCCTGGAATGGGG TTTTGCATTAAAATTCATCACAGATATTAG GCCTAATGATTCTGCCCAGTGCTCTATCC CGTGTGATTTTGTTTTGTATC I I I I I GTG TACTTTGGCAAGTAGGATGCAAGACAAA GCTTTGATATCAGGGTAATACTGGCCTCA GTCCTCTTTATTCTTCACTATCATCTCCTT TGAATCTGGAAGTATTTCCTCCTCTTATT AAGCAGAAGAAAGGAGTCACTTTTGTTG I I I I I IAACAGTTTAAGTAGGATTGGTATT CTGCAAGTTGCATTGCCTGGGGGGATGT AGTTCTTCATTAAATATTTGGTAGAATTCA ATGGCTAACACACTTCCTTAGCCACCTCA GCAGTGAAGCCATCAGGTCCCAGGCTTT GCTGGTGTCTCCCTAGGTCATGTTCCAC TCTTTAATGGGAGACTTTCTATTACACCT CCTAGTTTACTGGCTGTAAGCATAGCCTA TTGACCTGGTTACCTGTTACTGATCTCTT GCACTAGGAGTGGCCCAGGAATTACAGT CAGGTGTTGGTTTTCTTTATGGTTCAATT CCTTGTGTCCTAGACTGCCTTTAAAATTT TTGATTGGTTGTGTGTTTCTAGGAATTTA ACCTAGGACCCCACAGTACTTCAGCTCA TCCACTTATTCTAGATTTTCCAATGTATTG TGGTGGTGTGGCTTGCTGAGAAACTCAA GCATATGGTAGCTCATAGTAGACTCTAAT GTTTTGACCACTGAAAAGGGCAATACCC GATCCTTTGAATTTCTGTGGTATCAGTTG CTCTGGCAAGGGCTGCTCCTAATGCTTT TAATGTCACC I I I I IAATCTCTAATTTTGC CTTCATGTATGGATGCTGGCTGATCCTG A GCAGAGA I I I I I I CTTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1453926 4 59243973 AAAGGAAAACAAAATAACAAGGGGAGTT C/T AAATACTAATTTAAAAAGCTGGAGTAACT SEQ_0157

TGAAGCCGCTTGTTCTCATTGTTATAACA ATATTAATΠTGGACAAAATAGACTTCAAA

CAACACAACACAACTCACAGCCAGATGA ACAAGGAAGATAATTAGAGATAAAGTGG

GCATATTTCCTCATACTAAAGTCCTATTA GTCATTAATGATAAGTAGGTCAATTCTTC

ATTTAATTATCTACAACACMCTGACTTTC TCTAAGAAAATATAGTAACCCTAAACATG

AATGAAAGAAACACACAAAACATACCAAA TATCGGGGAACCTGCCCTGATAGTCACG

AAGTAAAAACCAAACAGTCTGAAGAAACA TAGGTTCTTTTCTATTTTCCTTAAGCATCA

AAGCAATAAACCAAACCAAGTTCAAATAT GCTGACTTGAGAAATAAAGGGACAGAGT

GACACATACATTGGAATTACCAAGGAGTT ACAAAAGAGAGAAATΠTAAAGCTGGGT

TAGAATAAGAAAAAAAGACAACTTTTTAT GTCCAAGGGAGACATTAATTGTTATTAAT

CTGGAGAATGCAAGCCCCTTTAAATTATC TGGCTATATTATCTTACATTTTGCAACATT

CATCCCAGAGAAGCATTGAAATGTGACA TATCTAAACTTTATGTCTTAAAAGAAACC

GCAGTGATGTCCTACAACCACCTTGAGC CTGCTTAGTCAAGAGCTATTACGCCATAT

TAAGTAATTACCTCCTGAAGCCCCTTGCT TTGCCTGCTCTCCAATATTTATAAAAACτ

ACATGGGCTCTAGACTAACTGATACCAA AI I I I I GAACTTTTCATTTCAATGGAAATA

GCAGTCATAGAATGCCATGTGCTAGACA AGACAGGAAGCGTTGTAAGTTAGACATA

CCATAACTCATACCCTATAGTAAAACAGG TGTATTTAC

GTATAGCCAATCACTAATCAATATTACCT

CCGTAAGCCAATGAGAATCCCTGTCAAA

CAACTTTGTATCGGCCCACTCCTGGTTTC S

I I I I I GCCTTTAAAAACCTGCTTGCAAAA ^

AAGGCTGAAAAGAGCACTCCCCAAAGCA

ACCTGGAAGTGTGTCGTGGGCAGCTGTC

TTCACTTTGGTTCAAGTAAACTCTTTAAAA

TTATATTTTGTGCCTCAGCCTCTTCCTTT

GGGTCAATAAGAATAAATACCATTAATAT

GTTGAGCCTTTAGTTGAAATGAACAGAAA

ACATAACAAAACCAGATAGATAATGTCAA

AATCCAAAGAAAGTGCTAGAAATAAAAAG

CGGAGAAATGAAGAATGCCTTCTGCGGG

TTCATCAGTAAATTTAGCATGGATAAGAA

AGAATTAATTTAACTTGAATATAAATGAAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12651639 4 59245004 TGGTTTCCTGCCCTGTACATCTGTATCTT A/C CTATGTAGATTCAGCTTTCTAAACTACAA SEQ_0158

AATTTTCCTTTTCTTAAAAGGTCACCAGT TAGTTTTCTTCTGGCTGAAGAATATGTAT AATATTGAATTTTGGACCCATCATAATCA TAATACTTATTGTAGGGTAGATCCGCTGA AGCATGACCTAATCTTAACTTGATTACAT CAATGAAATAAATAC I I I I I I CAA I I I I I G CTGAAAAGATCTTA I I I I i AGATAAAGTC TTTGTACGTTTATTTCTTCTTTACTTCTGA ACATTCATAGATAATGAAATGAGTGGACA AGAATATTTGTTGAATATAGAATTCTGAC TGAATTTTAAGGCAGTCACTATTCAACCC TTGGCAAGTTTATTCATTTCAGCACGGTA AGTAAATTGTTCAAGAATTTACAATATACA AAGATCTTACCCTATTGTCTTTCTGCTTG TTTTGTAATAATATAGGATCATATACAAAT CATAGCTTCTATACTAGTCAGGGTTCTCT AATACAATACTGCACCATGTGTACTGAAG AGAGAGACAGGACTAACAGGATAGATGT TTACATTATAACATAATATTCTTGTCTTCT ACATATGTAAAAGAGTTTATTAAGGAATA CCCTCCTGTCTATTTGACTAGTTTTCACT TTGACTCACAGGATCACAAGGTGAAGTT TATTACACTTTTACATTTTCTTCAAATATC CCAAAATAGGCAATCTGCAAGCTGAGGA CAATACAATATTGTAATTATTTCTTTAAAT GGAGCAAGGAAGCCAGTCCAAGTTCCAA AATCAGTTATTTGTTAGAGCCATTAAAAA AACCTCAAAAGTAAGGAAGTCAACAGTG TAAGGAAAAGAAGCTTTTATGCTTTTCTT CGGGCTTCAGTCTGTGGCCAAGGGCCC TTATTCATTCCTTTCTGACACA I I I I I CTT GAGAACCCCTGGCAAACCATTGGTGTAG C GTCCATGAGTCCA

RS12643918 4 59245072 TTTGGACCCATCATAATCAAGCATGACCT C/T TGTAGGGTAGATCCGCTGACAATGAAAT SEQ_0159

AATCTTAACTTGATTACATCTGAAAAGAT AAATACT I I I I I CAA I I I I I GTTTGTACGT CTTA I I I I IAGATAAAGTCACATTCATAGA TTATTTCTTCTTTACTTCTGAAGAATATTT TAATGAAATGAGTGGACATGAATTTTAAG GTTGAATATAGAATTCTGACTTGGCAAGT GCAGTCACTATTCAACCCAGTAAATTGTT TTATTCATTTCAGCACGGTAAAGATCTTA CAAGAATTTACAATATACATΠTGTAATAA CCCTATTGTCTTTCTGCTTGCATAGCTTC TATAGGATCATATACAAATAATACAATACT TATACTAGTCAGGGTTCTCTAGAGAGACA GCACCATGTGTACTGAAGTTACATTATAA GGACTAACAGGATAGATGTACATATGTAA CATAATATTCTTGTCTTCTCCCTCCTGTC AAGAGTTTATTAAGGAATATTGACTCACA TATTTGACTAGTTTTCACTTATTACACTTT GGATCACAAGGTGAAGTTCCAAAATAGG TACATTTTCTTCAAATATCCAATACAATAT CAATCTGCAAGCTGAGGAGGAGCAAGGA TGTAATTATTTCTTTAAATAATCAGTTATT AGCCAGTCCAAGTTCCAAAACCTCAAAA TGTTAGAGCCATTAAAAATAAGGAAAAGA GTAAGGAAGTCAACAGTGCGGGCTTCAG

AGCTTTTATGCTTTTCTTTTATTCATTCCT TCTGTGGCCAAGGGCCCGAGAACCCCT TTCTGACACA I I I I I CTTCCCTATGTAGAT GGCAAACCATTGGTGTAGGTCCATGAGT TCAGCTTTCTAAACTACAATAGTTTTCTTC CCAAAAGCTGAAGAACCTGGAGTCAGAT TGGCTGAAGAATATGTATTAATACTTA GCTTGAGGTCTGTAAGCAGCCACCATGG AAGAAAGATGGAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7670591 4 59247412 GTGTCATATTTGAACTTGGTTTGGTTTAT G/T TCCCATACTGCAGTGGGTATGCTCCAAC SEQ_0160

TGCTTTGTTTCTTCAGACTGTTTGGTTTTT ATCCCTAGAGCTGTGTTAGTAAAGCCCT

AC I I I I I GGTATGTTTTGTGTGTTTCTTTC GTCTCTTGCATATTAATATTTTCCCCGCT

ATTGAAAGTCAGTTGTGTTGTAGATAATT AGATGAGATAAAGTTGGAAGTGGGAAGA

AAATTAATAGGACTTTAGTATGAGGAAAT GCAGAG I I I I I I CCTACAATTGAGAGAAG

ATGCTCATCTGGCTGTGAGTTGTGTTGT TTTCTACTACTATCCTCTAGGGATGTCCG

GTTGTGTTATAACAATGAGAACAAGCGG AACCCTACAGATTTAGTCTTCTGCTACAT

CTTCAAACTCCCCTTGTTATTTTGTTTTCC TTTGTACTATTTTCTTTGGAGCTTCCCTAT GAGCTGCACTTCAGGAGAAGTCTCTTAC AACTCTCTTCTCACTATAATTCACTGTGA CTATTACTAGAGTTTTA I I I I I ATTAATGT GGTAGTATGGTGTGAGGGAGGGTTGTTC TCTAGTCTTTGAATTGTGTGGCAATCTTT AACGCACAATGGGCCCACATGTTGAGAG TATGGCCTTTTCAAGTGTTCTGGGGCTC CTCAAGGTTGAGCTTTATTTCCCTGCTCC TTGGTCTC rs6818886 4 59249178 AATTTTACAGTTCTATTAATTCTTAAAACC A/G ACCCATCTTGGAAGAGACTCTTTTATCCC SEQ_0161

TTAGAGAAATGTCAAAAACCAAATATAAA CAAATAAGTGTTCAGATGACTTCAGTAGC £

TGATATTCACAGTCATAGATAATAATGAA AGCCATCATCTTGACAACAACCTCATTAG *-

GATACCTCCAAGTAAACTAATATGGGCCA AGTATCTGAGACAGAACCACCCAGCTAA

AGTATATACAATTTTCATTATTCATTTTGA GCCACTGCCAAATTCCAAACCCTCAAAAA

TCGCAGAATGGAATTGATAAAATCTACAG CAGTGTTGTTTTCAGCTAAGTTTTGGAGT

AAGGAGGTGTTGCATATTGCATATTGCA AATCGGATATACAGTGATAGATAACTAAC

GTAGCCCAGTTCCAGGATAACTCCCAAA TCATCTTCCTTTTAGCAAGTCTTTCCTAAA

GATCCCCTACTTTTGGTATGCACAACATT TTTCACTTGTCTCATCTAGATTTGGAACA

GTGTAGTCCTCTTTCACTTGTATTAGGTT GGAACTGAAGAACAGCATATGGTGGGAC

TGGTCTGTATGATCAATAGACTATGGCAG TTCTGAAAAACTGC I I I I I GGCATTGTTTT

AAGTGTTGGTTTGTGGCTTCTGAGACTCA TATTCTAAAATGTTGGTTAAATGCAGTAT

AATATAAAAGGCCTTGTGACTTTCTCAAT ATΠTGCTTTCAAAACAAGATCTTATAACA

GTTTCTTTTCTTTTGGATGATTTGCTCTGA GTTTAAAAACTTCACTAACTCTT

GGAAAAGCAGCTGTCACATCATAGAGCA

CTCAAGCATTCTTGTGTAGAGAGCCACAT

GGCAAGGAACTGGGGACTTCTGGCAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6842153 4 59249805 TGCTGAAACTAAAGATTATCAAAACAACC A/G TTGGGCTTAGAAA I I I I IAGTTGCTTTTA SEQ 0162

ACACAAAGGTGAATTATGTTCATTAATTTT CAACATTGGAAAAACAAAATCAATACATC ATATATATTTATTTATACCCTGCTCTTTCC TTTCATGGAATATCTGATTTTAAATAACTT AAGGCGTTGTGTAGGTCATATGGGCGTA GGTTTCTTAGTGTTCCTGCCAGGATTAAT CAGACTTACCTTCCTCTTGTGTGGAATAG TATGAACAAACTATTCCTCTTTATACCTG ATCTGTGCCTGTTGTACCTTATATATATG AATTAATTGACTTGTTATGAAGTAATTTGA TTCTCAGTTGAGTAATTAGAGGCATTACT TATAAACCTGCTGATCTTAAAGAA TCCAAAATATGGACAATAAAAT rs2029740 4 59251340 AATCAGTCTCCTGACTGACTTTCTCTACA A/G TTGCCTCCACAAAGCAAAATTTGTAAAAA SEQ 0163

CTGTTGAGTTCAGTCCTAAATTCTCTGTT TTAAAACTAATAAAAAGCTTCAAGACTAA TCTTTCTCTGTCTCTCTGTCTCTCTCTCT ACAATGAGTATAAAAACATTATTAGCAAT CTTTCA I I I I I I CTCTCTCTATATATACCT TTTGATAAACCGAAACCAAGGAAAGTGC ACGTCTGTGCATATATAGATATGTATTTA ATTTTATAAGATAAATATGGAATATTTCCT TATATTCACATATAAAATATGTATTACATA TACATATGTATCTTTAGTATTCGTCCAAA AAATATGTAAATATATATTTGATAAAATAT CATTACTGAAGTATTAATAGAACCCTCAA GTATTTATATATGGACATAAGTATAAATAC GACATGTGCAATGATAACCTTCAGTAATC ATATTTCTTAAACTC I I I I I GAGACACAAA TTTGTTATTCTGCCAACTTTCAATGATAG AATTCAGTCAAGGTGATATTCTTCTTTATT AAAATCATGAAGTA I I I l I I I I I I CGAATT TAATTACTCTAATAATCTGCTTTGCCTATT GTAATTATCGAGTTAATTCTCGGGCAAAT AAGCCAACTTTTATGATGGTGTTTTGAGA AATATAATGTATTTTATTTAATAGTTTGGG TGTTCACAGCATTATTGTCTGTGA I I I I I I AGCCTCCA I I I I I AC I I I I I CCCTGTTCTC Ul TAAAAATGTAATTTATGCAACTACATTGC CTCCAAAGAAAAAAAAATAGTTGTAGCCC AATATGTTAACATTGATTATAAAATCCATG TTTCAGTGATAAACAAGCCAATTTTCCAT CTTTACTTCCATGAATTAAGGAATGCTTT AATCAGAAAAATTTTGCTTACCTGAAACA AGAAATTTTAAAAGAATTCTGATTGCT TCATATGCCCCAGTAATGGCAAATTATGG AAGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4865339 4 59254386 TTCATTTATTCTAGTATCAATTTCAAAATT A/G TTGCACTAACACATATCTGAAAAAAAATG SEQ_0164

ATTTTAAGTAAAGCCAATTTTTCTATTGTT ATTTGATAAAGAATTTTCTATAAATAAGTG

TCTGTATACGTATATTGCTTCTAGTAACA CTTGTGCTGCTTAAGTCCTCCCTACGCTT

CCAAAATATAAATATAAAAGAAACTGTATT CAAAGCAATGCTATCTCCAGCACCGGCA

TTAAAATAAAGTTACAATTATAATTTATAA GTGCCACTGCACTCAGACTTTCACTCACT

GGGTACCACTCTGTCTTTGATAAATTCTG CTGTTGCTTTTAGTCCTAAGGAAATTGAA

TTAATGGTTTGGAGTTTACATTAGCATΠT GAAMCAAGCCTTTCCCTGAGGCTTGAA

TTCAAACCTAGAATTTCATGACTGCTGAT CCTTGCTAATCACGAAAATGAATGTCTAG

TTGTACACAAGTAACATTTCATAATTAACA GATGGGGGCTACAAGTGTCAGTGTTGAG

ATTAAATATTTTATAATTTGAAGTTACAGA ATAGATGTCAAGGGACAGAAGTGCCAGA

AATTACATCTGACCTGTTTAAGTTGTGAA AGTTTCATAAAGGATTTTGTAGTAAGTCA

TTTGATGAGAATAATTTTCTTGCTAATTTT CTTTGGAATTTGTAAAACCTGGGC

CTTTGTTTTGATCCATAATTAAATCTTCAT

TAAATCAAGGATTTATAATATCTTGATTGC

AAATTTTATGTGAGTGATGTTGGAGAGAA

ATCTGCTCACTTTGTCTCCAGATTTTAAA

ATGTAAGCATGCTGTGTTTCAAAGTTTCC

I I I I I I AGCTTTGCAG I I I I IAAAAATAAA

CTAAATTTCTATCTTTCATTCCTTATCTTA

TTCTAACTTACACTAGCTCTGAATAACAA £

TCTAAATAAAGTAAAAAATAAAAAAAATTG ^

TATTCAGAGTACATGAAATTTAAATATCC

ACTTATCACTAAGGCAGTGCAAAATTAAA

TAGTAAAATCA I I I I I CATACATTTCTAAA

GCAACTTATTTCTTTTCTAAAATGTTAAAA

ATTTCTAAGATATCCAAATGTATACAAATT

ATGATTAATATCAAAACATTAAATAAAACT

TTAAAAATCAGAAAATTATAATTTACATAA

TAAAAAAATTAATGAAAATATATTA I I I I I

AGAAATTAAAATTATTGGGTTAATCTGCC

ACTAAATGGTACTTCATGAACTAAAAAAT

TATATGTAGCGCATTCTATATGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1159171 4 59263075 AGCAAGAGGATATATCAAATACTGGGTG C/T AAAGTGCGAGAAAAAGACATTTTAACATC SEQ_0165

GAGGTAAAGAATCTATTTCAAGTACATGA TACAAGATGTCAAAAATGTATTTCCATAA

ACAAGAATATTCAAATAAATGAAAATCTA ACCTTTGTTATAAAGCTTCTTGAAGTTGT

AAGGCATATTGACAAAGTCTCTCTCTTTG GCTCTATCAAATTAAGTGAATATTTCAATA

ACAAAACTTGGGCAGTCTCCTCTGAGCC CATACTAAGACACAGAATACAGAAAACTG

CTCTTTTCAAGCAGGCATAAAACAAATAA AGACTACAACTCAGATATTAGGTATAGTG

ATAAGTTGTGGTGTTACCMGAATGAAAT AATCCCCAGGGTTATGATAAAAAAGATTC

ATTATGTAGCATGACATGAATGAATCTTG CAGGTCAAAAAGTATGCATCAATATTAGA

TGTACATTATACTGAGCAAAGCCAAGCCA GAACAGGCAATTCAAATTGGTTGGGTTTA

ATACCAAATGATACATATTGTGTGATTCC CAGTCTTCTAGAGAAATTTCTTTAGGTAA

AGTTATATAAGTTCAAAAATGTTATAAACT ATGAAATGGTAACACCATCAGTAGGAGA

ATTTTATAGCAATAGCAATCAGAATACAG GCCAGGAGACTCCAACTACAGAAAATAT

TTCATGTGGAGTGGACATTGACTAGAAG AATTGACCAGAGGTCCCAGCAGCAGTGT

TGGGATATAGAGGATGTCCTAGACTGAC TCAGAAATCTTTAGTTGGATTTACAATTG

TAAAATATTCTGAATCTTGGTTGAGTTTAT GGCCACCTCAGGACATTACTTG I I I I I AA

GAAAACATTTACATTGGTGAAATTTATTAA TA I I I I TAAAAAGTATACAGCAGGAATGT

ATTTTAAATTTAGAATTTGTATATTTAACT ATACTAATTATAACTGTATAGCTCAGTGA

GTTTTACTCAATTAAAAATTTAACCAAAAA ATAATC GTAAATGCAATTAAAATCACAGAAAATGT

TATAAACAACCAGATATTTA 5 rs282717 4 59275038 TTGTTTAAAGATTTCACATATGCCACCAT A/G GGGAGGTACCAGTTGAGGTACATAATCT SEQ_016S

TTTTTGCCACTAAGTCTTAAACTCAGAAA GCTGGATGCGAACCAAAACTACATGGTT

ACACTCTGAGACACTTGGATAATTTCTAG CACAGGATAGGTGATCACAAATTGGGGG

ATAAAGCTGTTGCTCAATGAATGCCACTT AAA

TTAAAATTCAAAATATATTCTAATΓTCTGC

AGTAGGCCAAAGGAATAATAAGTGTGGG

GCCAGAGGCACTTTCTATGGAGTATTGA

CTAAGAGAACAAGAATGAAATTGAAAGAC

AGGGAAGCTATCAGTGAAAATACACTGTT

CCTGGGCCCGAAACTAACTGGATATATG

GATGCAAGCAAAATCTTTGGCCAAGGTA

ACTTTCTGCCTTTCCTCACACACTCTAGA

GACTTGTAGCCCTCTCACAGGTCATTTAT

CTTCTCAATAATTGTTTCCTTTATGGTGCT

ATCTCCCCAGCCATATATCTTGATGATGG

CAGACAGGTCCAAGTAACCTGATAAATTA

CAGATAGCAGTCTAGTCAATGAATGGCC

TAGACCCCAAAATTTATTTTACCATGCCT

GCAATAAAATGACTGATAAATACAAATAA

GGAAGCCTAAAACTGTCTTATGACACAA G

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs282745 4 59293321 CAGAAAAGTGGAATGTAGTATAACAGAAA C/T TGTTTCTCTCGTACCATAGCAATAATTCC SEQ_0167

TTCAGGTAAATGCTGCTAATGCTCCCTTG CTTAGATAAAAAATGTAAAAATGTAATTAT

AGTAACAACTGAGAAACAAGAACAGACA TCTAAAATAGTTGTATAAGTAATTCTTTAG

TATAGCAAATAAGCTATGATGGACTTGTG GTTAAACACATGGCTAGCAAAAAAGGTG

AGTGTTAGTCTGGCCAGGCTGAATCACA TTCGCTCTGAATATAGCTATGCATCCACC

TTTCACAAATATATTTCTA I I I I I CTGGTT TTTGAAGTACAGAGCTTTTATAAAGGATC

AGGGTGGACTACCAAGAAGATTCTCACA ACTCTGACACACTATTATGTAAAAT

TGAGGGCGCAAGGGAGGCAATAGCCATT

TTGTAGCATACACGTGTGCGCAGACACA

CACACACACACACACACTGTTGCTAATC

GGCTGACTCACCTCATTGGTGTGAAGCA

GCAGCCGTGTCTGCAATTGCTCTACCTT

GCCTTGTATCCTCCTTCAGTTTCTCTGAC

TCATAGGCCAATGTGTGTTGAACTCTTTG

ATGAAAGACCTGGCTTCTGCAGGATACT

CATGTCCTCAAGGTTAGAGACAAAAAGA

ATGAACAAGGACACGTGTTTCAATTCATT _M

CTTATAGGTTCCAGCTTGTGGGGTTGCA g

GGCTACTCATGATCTTTCATTCCTGACTG

TCCATGGATTTAGCTTGAGCTCCAGCATT

AGACTCAAAAACAGCCTTGCAGCTACTG

TTCAACCAGCCACCATGAATGTTTAATCC

AATTCCCTGTTATCTATCCATCCTACTGG

TCCTGCTTCTCTGGTTGAACTCTGACACA

TAAGCCAGTAGAGGAGATAAATAAAAATA

CTTTAAAAAAGATCTGTCACTTAGGGTTC

AAGGATGGGATGCAGGCTGTGAAAAATC

AATCTAACTACTTACGGAAAGGAGTAAG

GAAAATAGCAACTGACCTAAATAACTTTA

AAAGTATCTTGACCAGTTACTGTAAGCTA

AAACAACAAAAAGGCTGTACACAAATACT

GTAGTCTAATTATTAATTATATTTCTCACA rs2662836 4 59316566 CACTATCTTTGAAAAAGAGACCAGCCCTT C/T TAGAGATAAAGGAGGATAAAGTTGTCTCA SEQ_0168

CACCAGTCACCAAACCTTGATCTTGGATT GAAATTCCATGTGATTGAACAAATATGCT

TTTCAATCTTCAGAAATACATTTATGGTGT TTATGATAATCCTTTTGAGATAGAGGCTT

TCATAAATTACCCAGTCTCAAGTATTTTG TTGGTATACAGTTGGATAAGATACTTTTA

TTATAGCAGGTCAAACTGAGTGACATAGT TTTGTGAGGCTATGGATAATTTTACATTA

GATATTAAGAAAACTTTAA I I I I I I I CACC AATATTAGAGCTATGCAGTAAATGAAATG

TTTATTTTCTAATATTCCTGAACC CAATATATAATTAGTTAAGCAGCAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs282729 4 59321995 AGCTTTAAGGTCCTGGGTAACAGAAATAT GfT GCAACATGAATGCATTTTGGAAAGTGATG SEQ_0169

ATTCTAAAAATCCCCAGGGGAGTGGTGG TTGAGTGAGAAGAGTAGGGAACAGAATG

TGTGCACTTTTGTATTTTCTTGATGAGCA GGATTCATTGAAAAGAAAACATGATTTAC

AGTCCTTTTGGCCCTGTCTTACTCCATTC ATTTAAAACATATAAAAGCAACACTCTAT

CTGCTGCTGTAATAAAATACTACAAACTG GGAGTGGACTGGCAATTGAGATAAAAGT

AGTAATTTACAAACATATATA I I I I I CCTT AAGAACAAATATAGTAAGCCCTAAATTAA

ACAGTTCTGGAAACTAGGAAGTATAAGAT GGAATGTGTTTAATCTAACTC I I I I I I I

CAAGGTGAGGGCAGATTTGGTGTCTGGT

AAAGGCTTGCTCTCTACTTCCAAGATGAC

ACCTTGTGCTGTGTCCTCCAGAGGAGAG

GAACGCAGTGTCCCCACAGGCCGTAAGA

GCCGTAAGGGAAAAGGGGCTGGGGCAC

TCACCTTAACCTTTCAGATAATGTGACTT

ATTCTATCCATGAGCACTCCACTCTCATA

ACTTAGTCATCTTCCAAAGCCCTCAGCCC

TTAGTGCTATCACATTGGAGATTAAGTTT

CCACATATTAGTTCTGGGGGACACATTCA

GACAGTAGCAGCCCTCCTAGATCTCTTA 5

CACTGTGGGGAGGCACAACCAGAAGAA

GGCCATAGTGAAGCATGATAAAGACCCT

TGCTTGGGCCTCAGGGTGTGACTGACTA

AAGCCGGGCATATGTAAATGACATATGA

GATCCTTTAGAAGTGAGGAAATAGAAAG

ATCTTTCTTTAC rs282705 4 59343615 CTGTGAGTCTGGCAGTCATTCAAAACTTG C/T ACGGTGGCTGAGTTTGGTGCTATTGAGT SEQ_0170

GCAACAGCAAAGGAGAACCAAGTGGCTT TGTTTTCCTTGTCACCTTAGGCAAGCTTG

TTATAATGTA I I I I I AAGTGAAAGTCATAA ATGGTTAATGGCATCACTAATAGGATATA

AAAAAACTCCATTTCATTAAGTGCTTAAA CAGTCAGTTATGGAGTTCTAAACTAGCTT

AAGAGCTTCTTGAAAACATATTCAGTTCG GAATTAGCTATGACTAAAATCAATTACCA

AGAAGCCCAGCTCCCAAGTGAGTCCTGT CAGTCCACTGGTCCACAGAAATCAGGGG

CACTCCACAGTAAGTGAGTTTATTTTC GTGCTCTCATTTCTCTTCCTAGTGAACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs282709 4 59347634 TAAAAGGACAGAAATGGAGACAGTGACG C/T CTTGTCAGTTTTACCAGTGACCTTCATGT SEQJD171

GCAGCACCAGGTCCCTAGCACAGTTTCC TGATAAATACAAAGATA I I I I I I GGTCCT AAGCACATACCAAATTCTAATTGTTCCCA CATCTTAACAGAAAACAGCGGCATATGA TTC I I I I I CTAACATTTCTCCTTAATTAAG CATACTGGTTAATCACTCTCCCTTCTCTT GGGATTTCTGCCATATGACACCAGTATTC CTTCCCCTAAATTTTAGGTTATCTAATTG CCCCTGCTCTACAAAAAATGTCTGTTGGA CCCTACAGATTGCTCCTTCTGTCTTCTCT GAGCTTCTGCCTACATAAAGACTGTATAT TCTGGTTTTCCCACTCTGATCCACTGATG GTTGCAGTTCTTCCTTTAATTTTATTACCA TTAGAGTGGTCCAGGGCTCTCTCTCCTG TTAATGTCAATTGTGTTCTTAATTCTGCCT TCTTTCTCTCTCCTGTCTAI I I I I IATTTT GGAAATAATAGTAAATATCTCTTATCCAA GATTTACACTCACTTGGTAATCTCATCCA CTATTCTTCTACACGACTATTATACATCTC CTGTAATGCTACAAACCCTGCATATTTGT CTCTCTCAAACTTCAGCATTTATCCTTCA TCTCAAATGTTTCTCTCCAGGGTACACCA TTTACACTCTCAGCTGGTGAACTTACTTC CTCTCCTTCTGAAATCCAGACATATATCC TTACTTGACTAAAGAATTGAAAGCAATGC ATTCACCTACTCTATCTCCATTTGAATGT AAAAAGAATGTCCACAGATTTCTACATTT CTAGTAGACATCTCAAACTCAACATGGCC ACATTTGTTTACTTATTATCGTCTGTATCC AAAACTGAACTAA I I I I 1 I CCTCCAACCC ATTAACTTAGGTATTTCTCATAGTAGTAAT TCAGTACTCTGCTTCTCCAAGAACTΠTA K* GAAGGAACTGTCTTTGCTCCAGTCCTAA AAAATCACTGTAGATGAGAGTTACATCTT O O GTGAATCCTTCCATTGGTGTACTTGCTCT TCCAAATGTTCAGACCAATAGTTTTCCTG GATCCACTCAGTTATCCCAAGGCCAATC GGTTTCTCATTTCTCATTTATTAAGAGTTG CCCCAGGAATTACTCCTTCCCTTCAGCAA AAGTTCCTATGTΠTAGAAGGCCCTATGT CATCATTTCTTTCCTCTCCTTGGACTCAA GGTCTGTCCTCTCTTATATCCTCTTCTGC TCCTATTAGTGGATATACAGGTCATTTGT CACTCTTTCTTACTGACTTTGCTCTTACC TTTCTATTAAAAATCTTAATTCTCA I I I I I C ACACTGAACTCACTGCTATTTCTCAAATT TTCTAGTTATTTCTTCACATTTGTGCTCAT TCTCACATAGAATTATTTTAATCTCTTCCT GTTTACAGCAAAATTA I I I I I GGAAGAGT GCAATTTCTTTCCATACACCTTTCTCATCT TGCCTATACTTATGATCATAAATCTCTCTT CCTTCAAAATCTTTGCTCACATGTTACCG ATTCTAAACTCATTTAAACCTACTGTAGTT TCTACATGAGGCCTGCTTTGACCATTCTA AGTTATCTGCCCCC I I I I I AAACAAG TTTGAAGTTTGCCACACTCTCCCCAAAGT

GTCCCTACCCTCTCATTCAGTGCCATTTT

CTTTTATGTTATAGAACCTATCTCTTTTAA

ACATACCATAGAATTTTCTTATTCATTACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs282710 4 59348193 ACAGTGACGGCAGCACCAGGTCCCTAGC A/G TTTCTCATTTATTAAGAGTTGAAGTTCCTA SEQ_0172

ACAGTTTCCAAGCACATACCAAATTCTAA TGTTTTAGAAGGCCCTATGTGGTCTGTCC TTGTTCCCATTC I I I I I CTAACATTTCTCC TCTCTTATATCCTCTTCTGCCACTCTTTCT TTAATTAAGGGGATTTCTGCCATATGACA TACTGACTTTGCTCTTACCACACTGAACT CCAGTATTCCCCCTGCTCTACAAAAAATG CACTGCTATTTCTCAAATTTCTCACATAG TCTGTTGGAGAGCTTCTGCCTACATAAAG AATTATTTTAATCTCTTCCTGCAATTTCTT ACTGTATATGTTGCAGTTCTTCCTTTAATT TCCATACACCTTTCTCATCTCCTTCAAAA TTATTACCATTAATGTCAATTGTGTTCTTA TCTTTGCTCACATGTTACCGTCTACATGA ATTCTGCCTGGAAATAATAGTAAATATCT GGCCTGCTTTGACCATTCTATTTGAAGTT CTTATCCAACTATTCTTCTACACGACTATT TGCCACACTCTCCCCAAAGTGTCCCTAC ATACATCTCCTCTCTCAAACTTCAGCATT CCTCTCATTCAGTGCCATTTTCTTTTATGT TATCCTTCATTTACACTCTCAGCTGGTGA TATAGAACCTATCTCTTTTAAACATACCAT ACTTACTTCTTACTTGACTAAAGAATTGA AGAATTTTCTTATTCATTACATTTATTGAT AAGCAATGCAAAAAGAATGTCCACAGATT TTTTGTCTCCTTCAATAAAACATATGCTTT TCTACATTTACATTTGTTTACTTATTATCG ATAAACAGGGAi I I I IATCTCTTTTGTTCT TCTGTATCCATTAACTTAGGTATTTCTCAT CAAACACCTAGAAGAATGCTTGAAACATG AGTAGTAATGAAGGAACTGTCTTTGCTCC ATAGAAGATATACAATAAAATTTTGTACAT K* AGTCCTAAGTGAATCCTTCCATTGGTGTA ACCATATAATTTTCTTATTCGTGACTTTTA O CTTGCTCTGATCCACTCAGTTATCCCAAG TTGA I I I I I GTCTCCTTTAACAAAACATAT GCCAATCCCCCAGGAATTACTCCTTCCC GCTTTATAAGAAAGGGA I I I I I GTC I I I I I TTCAGCAACATCATTTCTTTCCTCTCCTT TGTTTTCAAACTCCTAGAAGAATAATTGA GGACTCAATCCTATTAGTGGATATACAGG ACCATGGTAGGTGTACAATAAAATTTTGT TCATTTGTTTTCTATTAAAAATCTTAATTC CGAACAAATGAATGAATTACTGGATCAG TCAI I I I I CTTCTAGTTATTTCTTCACATT GAAGACCGTTCTTAACATTGTTAAAAAGC TGTGCTCATGTTTACAGCAAAATTA I I I I I AAATGGTTGAGCAGAAAACAATAATATGT GGAAGAGTTGCCTATACTTATGATCATAA TGACTATGAATGTAAACATTGAAGAGCTG ATCTCTCTTATTCTAAACTCATTTAAACCT AAGGTTGTTTTGAGATTTGTGGAGAGGA ACTGTAGTTAGTTATCTGCCCCC I I I I IA AACAGTATAAACTTCCATTTTATCAAACC AACAAGTCTTGTCAGTTTTACCAGTGACC ATCTAACATTTGTAAAATGCAACTTTTGG TTCATGTTGATAAATACAAAGATA I I I I I I AAACTGCA I I I I I I I I I I I I I I I I I I GTGA GGTCCTCATCTTAACAGAAAACAGCGGC GACAGAGTCTCTCTCTGTTGCCCAGGCT ATATGACATACTGGTTAATCACTCTCCCT GGAGTGCAACAGCGTGATTTCAGCTCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs282716 4 59362583 GCCCTATTATTATATGAGAAAACTGATAT A/G TTAGTCAATTAACATGGTAATCTGCAGGA SEQ 0173

TTGTAATGGCTAGGAGACTTGTTCACAGA TATATGAGCAGTACATTTTCATAGTCACC ACATAATTTCTATATAAAGAGTTCAGATTT AATGCATGGGGAAGTAGAGGTAGCCTGG AG I I I I I I IAATTTCATTTATTCACCAGTA GAGGTAGGGTAAGGATGAGTGGGATATC AATATTGATTCCATTCCTATTAAGTGCCA ACATCATTAAAAAAGTTCATCAAAATGGC AGTACCAATATGGATTTCTGACATGTATT I I I I IAGTGACTGAATGTTGTGTTCCCCC AGTGAAAAAAACAAAACAATATATCTGTC AAAGTTTATATATTGAAATTTTAAGCCCCA ATACAGCAGCACAGCTTACATTCAATTGG AGTTGAAGGTATTAGGAGTAGGCTTTTAA GGAAAATCAGACAACAAACAATGAACATT GAGATGATTAGGTTATATTCTGGATCTGA AAATGTATTAATA I l I I I IATCAATATTTAT CAGGAATAGGATTAGTACCTTAA I I I I I A AAATTATAAATATCATTTAAAATATTAAAT AAATGACCCAAGGGAGCTCTCTGGCCCC ATATTAAATGATACGGTAGGCTAGGACA TTCTGCCATGTGAGGACACAGTGAGAAG GGTGTTAGCAA I M I I GCTGAGTGACAGA ACATCCATCTGTGAACCAGGAATCAGGC TAAGAAATATTTTAGGCTCTTTAGGCCAT CCTCACCAGAGAAGGAATCTGTGGATAC TAAGTCTCTGTTGAAGGTACTGAACTCTG CTTGATCTGAGACTCCCCAGCCTCCAGA CCATTGTAGTGAAAGTAGCCATAGACAAT ACAGTGATAAGTAAATGCTCATTTTTAAT ACATGAACAGATTAGCATGGCTGTGTTC CAATCTAATCTATGGTATTTGTGTTACAG CAGTGAAACCTCATTTGCAAAACAGATGA CCACCGAAATAAAGACAAGACTGAATTAA K>

O K* ACAGCTGGATTTGACCCATGGACTGTAG AAAGCTGAAGTGTGAGCAAAGATTTGAA CTTGCCAACCTAGGATAAAATGTAGCGT GAGGGTATGAG I I I I I I CAAGCAGACACT GTACTTGTCCTGTG I I I I IAAAGATTCTG TGACAAAAAAGCATATTATGGTAACGAAA TATTTGTCTGTTTGGCATCCATTAATCAT TCCTTAGATTAAAAGGCCTTTATAAAAAT GGGGCCAAAATAACACTCAAAGTTGTTTT AAATGTGCCTAGCAAGATGCAGAAGCAA CATCTCCCCTGTGATTCAGCC I I I I I GGG CAAGAATGCCAGTGTGGCTGGAGCAAAG AACACAAAAATCATATTACAAAACCTCCA TTAATGAGAGAGAGAGCTGAAAGGTATT ACAATCCCAAAAGTCTATATCCATAAACA ATTTCAGATTATAAAAGACTTTGTGAGCA TTTATATAACTTTCACCCACTAAGCCAAT ATGATTTCAGTGTTTACTCAGGATGAGTA ATTTCCCTCACCCTAAATCATTCTGTGCC GGGCAAGATGTTACAGCATGTCTACACA AGGTACCAGATGACTATTGATCACCCCAT AATCAGTTTGTGCTGCTGTAACAAAATAC ATCCCAGAGCCCGCTGACATTATTCAAA CTGAAACTGGATAATTTATAAAAAACAGA CTAGCTAATCCTAAGCTGTTTCTCCTGCT AATGCATTTCTTACAATTCTGGAGGATGC CTGCTTTACC I I I I I I GCTGAAAACACAA ATAGTCCTAGATTCAGGCATCTGCAGGTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1868419 4 59553968 TTTG I M I I CTTCTGCTTTTCATGGGCCA A/G TCTACTTTAGCCAAGCCCAGGTATCAAAT SEQ_0174

GTATCAACTAAAGATTGTCAG I I I I IAAG GTGGTCAATGGTATACTCTATATCCAGTA ACCTTACTTAAGGATGCAATGATTAGTAA ACCTCAAGAATTAGAATA I I I I I AGTTAAA AGAAAATTCAACAATCTTATGTTTACCTG GGGACAAGTTTAAAAAGATGGCTGACTC ATAAATATCTTATGAGTGTATGCTCCAGG ACATATTACTTAAGGTCTGTAAGCCTAAT GTACAACAGGGGTGAAAGGTTAATTTGT GTCATTAAAAATATG I I I I I I GCTTCCTAC CA I I I I G I I I I C I I I I I I I C I I I I I I C I I I l TTTCATCTGTΠTAGCTTAATTTTCAGTCA TTTAATTGAGACAAGATCTTGTTGTGTTG TTTGAAGATGT CCCAGGCTGGTCTTGAACTCCTGGGCTC AAGAAATCCTCCTGCCTTGGCCTCCCAA AGTGCTAGGATTAAAAGCATAAGCCACC ATTCAGACTAATTCTGCTCTCATGTAAGT GTACTATCAGACTCACAGTTTGAAATCTG TAGACTGGCACCGCCTTCT rs 1449043 4 59562234 ACACCCTGGAAAAAAAATTTTTGTACTGG CfT AATTTTATTGATTATTCTGAGTTATTGAAA SEQ_0175

GCCCTCACAACCTAGGATCAGTCCTGAC GACCAAGTTGTATAGTAAGAATTGATTTG ACACACACACACACACACACACACACAC TGTATAGTGATAAAACTCTTATTACTTGA

K* ACACACATACAGAGACAGAGAGAGAGAG GTTTATGTGAGAGTATCTCTC I I I I I IATT O AATAGAGTGCAATTGATGAAATTAGTTTA ATTATGCTATAAGTTCTGGGATACATGTG TTTTATAATTATTATTAATGAATAAAATATT CAGAATGTGCAGGTTTGTTACATAGGTAT TTGTGCTGGGATAAAAATTGATATGGTGA ACACGTGCCATGGTGGTTTGCTGCACCC GGCTGTTGTGAATTTTAGATACCCTTTAA ATCATCCTGTCATCTACATTAAGTATTTCT GATACATTATCTGATAGCTCTATTTCTTTC GCTAATTTGTACATTATTTCTCCCCTATCT CTTATTCCCCTGAAGCC CCCAAACCCCTGACAGGCCCCAGTGTGT GATGTTCCCCTCCCTGTGTCCATGTTCTC ATTGATCAACTCCCACTTATGAGTGAGAA CATGTGGTGTTTGTGTTTCTGTTCTTCTT AGTTTGCTGAGAATAATGTTTTCCAGTTT CATCCATGTCCCTGCAAAGGACATGAAC TCATCCTTTTATATGGCTGTATAGTATTC CATGGTGTATATGTGCCACATTTCCTTTT TCCAGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SE

RS1562673 4 595661 1 1 GCAAATAAAGAAATTTGCTGTATTACTCC C/T TTTATTGTATGGCATTATGACCAGTCATT SEC

AAATTCCTGCATGGTAACAATTTCAGAAG AGGTTTGGTGMTTGGTTCTTCTTGCTM ACCAGTTTGGAAGGAGTAGTTACTCTTTA TGTTTGTGTTAAATTAAAMCA GTTTGCTGAAATTGTCACCTGATAAATTT AATTAACTTAAATTACCTATCACTTCTCTG TGGATATTTGAATCTATGTCTCATATTCA GACTAATCATTTAATTTCACAGGTGAGAA ATTAGAGTTTAATTATAATTAGAGATAGG TGACCTCACAGAAGATGATGGTGATGAA AATTGGTTAGAACAGAAGAAATCTTTAAG TTTGATTTATGTTTCCACCATACAGTGGT AATTCATCCATTCTGACAGTTTGAAAATT ATAAGCAATGTCTTTTGATTATTCTAACAC ATAACCACATTTTAAAAATATAAAGTTAAT TGTCAATCACTCTTAAGATTAATTGTCATT K*

O CTTAAGAGGTACCTTGGCTAGGATACAC 4- ATGTTAATTTATTTAAATAATTTAATGAGC MTAGAGTMCATTTTGAATTTCTGAACTT TACTTCMTTTTCTMTACTMTACMTGA GAAGGTGTAAATTGCTCCAGTGTTTMTG TTTGGTGM I I I I I I AAAGGTAGMTTCA GCATGCAAGMTATATCMTMGGCATAG AGCATAGGTTTTGTGTTGTATAGTTTTGC AGATAAGAGMTACTCCATTTAGGACATT AATTTTATGTTTTATMCAACAATTTGTAT TAGAGCCTTACTGCCCAGAAAAGGGTGA CAAATGGACTTCCCAAAMCATMTATTT TTGAACTTACTTTTMTGGGAGCAGCTCT CCATTCTAMGCTGTACTCCATTTTAGTT TATCMCMGGCAMTCTAAGTTATAGAT MTTMCTATTTTGCTTAAGTTCAAMAGC MTTTCAACACMGAAGCAAATACAMCT

RS 10006753 4 81567021 TTTATACTTTAAAGTATTTCTGGGTTAMT A/G AACTAGTAAACATATGTTCCTMTAAGTG SEQ

GAAACAATGAAA I I I I I I AGTATGTTCM MGGGAAAGATAATAATGATGGTCAACAA

CTCTCATCCAMTGGCATATGACCCTGTT TAAGCCACGTCMTGCATMGTTGTATAG

TACACAGCCTAAAGCTAAAAATATTACTC GCTAAATGTTGCTTGTAGGCTACATTAAA

TAGTTTATTCTMTCTATTGTTMGTATTG CTCAMTGTAATAGTTTATCTTATACTCCT

TGCACTGTATACCMGTTCTTAGGGCACA GGTTTGATTTGATTAGCATATTMCGTGA

TGAAAMTTTTAGCTGCCAMCAG AAGTAGGATAGCTACTAAATATATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1458037 4 81575910 GCAACAGGTCAAGCCAAAGATGAGATAT C/T ATGTGGCACTTTGTAAAACATGTAAAAAT SEQ_0178

GGAGTAGAGACAGAGAAAGAACTCAGAA GTGTTTTATGAAGAAAGGCTGACCAACTT TTTGTTTAAAGGTTTAGCCAAAAGGAGTT TTTGAGAGACTTTCAGAAATGTCATTAAT GCTGGCGTACTGGATGAGGGTTATGAGA AAGTCCCAAATTGATCACATG GAAAGGAAAGACACAAGAATGATTCCAA A I I I I ^"I GGCTCGAGTCACTGAATAAATCA TCATGCTGTTTATTAAACTGTAGAAGTCT GGAAGCTTAACTGGTTTGGGAACAAGAG TTGAGTTTTGAACATGTCAGCCTTCAGAT GCCTGTTAGATATCCTGTAGCAATATAGA ATTGCTGCAACAGGCAGTTGGCTACGTG AATGTGAAATTCTGGGAGAGGTTGAGGC TGGAGATTTAAATGTGGAAGTCGTCAGC ATACATCTGGTATGTAAGGCGGAGGTGA AATCACGTAGGAAGTGAGTTTACAGAAA GAACACAAAGGAGGCAAAAACTGAGCCC TGGGGTCCCACAAGGTTTACAGGTCAGG K*

O TAAAAGAGGAGCTAGCCAAAGAGACAGG AAGAAATAGCTGCTGAGGTAGCAGAAAG GCCAGGTG rs13108940 99799667 CAGCACAGATTAGCCATTCATGGAATCG A/G CTTACTGCCCATTATAAAAGATCGGAGTT SEQJ3179 GTACTTATCTGGTGCCTATTTCCAGAAGA CCCTAAGTTCAGGGTTCCTCTCCTAGAAT GTTTGTGTGGGGAGACAATTCTCACATCT ACAACTCACTATGTATCACCTGGCCCTCT ACAC I M i l I GGGGGGCAGGGTGGGGG CTGCACCACCCTGTAAGAATTAGGGCTC GGATAGAGTCTCGCTCTGTCGCCCAGGC AGGGAAAGTGTACAAAAATATTGATCCTC TGGAGTGCAGTGGCGCAATCTCGGCTCA TGGTTCCTGGCATTGCTGTGATTAATAAA CTGCAACCTCCACCTCCCCGGTTCAAGC GTCCTATGTGTCTGCCCCAGCAGTGTGA GATTCTCCTGCCTCAGCCTCCTGAGTAG TGCCTTCTGCCAGGATTTGTGACACTGT CTGGGATTACAGGTGCGTGCCACCACGC GGCAGGATAACTTGTTTGCTGGCATGCA CTGGCTAA I I I I I GTA I I I I IAGTAGAGA GGGTGAAATCTCAGACCCTTCACAGTCC CAGGGTTTCACCATGTTGGTCAGGCGGG TTGACACTCAGTGTTATTGTTCCACAGAA TCTTGAACTCCTGACTTCGTGATCCACCT GAGTTTGGTGTCTTAGATTGTTCTCCAGC GCCTCGGCTTCCCAAAGCACTGAGATTA CCCCTGGCTTGCTTCAGCTTGCCCTGTG CAGGTGTGAGCCACCTTATCAGCAAGGC GGATGTCAGCACCATCAGAGCTGAGGAG ACTGACATTACAAGTGAGTCCTTCGTTAC GCTGCTGAGATATTAATAGCTA I I I I IAA TATCTTTTCAAGAAAATTTGAACAGCAGA AACACTTATCACAAATGCTCTCTCTATGC TAGCCTTGAAAGATTCAGTGTTTCTTTAC CTATATATCTGTGTGTG I I I I I GAATTTTA AGAGCAAGGGTCAGGGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4699639 4 99801210 TCCTTTGTTGTGGATGACAAATAACCTCC C/T ACTATAAAAAGAAATGGAATGGATTCCTT SEQ_0180

ACATAAAATGTTCTATACACTGAGGCATC TCAACCAAGAACATCAGCACTGCATACTA TTTGATCCATCTTACTGGCTCAGTGACTC AGAAGTAAAGTACTGGCTTAACACAGAG ACAAAGGAGGAAGGAGGGGGGATGTCT CCCACAGAAGCCACCGAATATCATCCTC GAAAACAAAAGGGCAGCCTGACGACACC TCTCCTTAGTTAGGTAI I I I I IACAAGGA ATTTAGTTATTTATTCTGTATGTTCAGCTC AAATGGGTTTTGACAAATCATTCTTTTATA AG I I I I I CCTCTTTCCAACTTTTCATGA TGTTCTTTTATATAAGACTTTAATGCA rs4699640 99801320 GTCTGAAAACAAAAGGGCAGCCTGACGA A/T CCTCTCTCCTTAGTTAGGTA I I I I I IACAA SEQ_0181 CACCATTTAGTTATTTATTCTGTATGTTCA GGAAAATGGGTTTTGACAAATCATTCTTT GCTCAG I I I I I CCTCTTTCCAACTTTTCAT TATATGTTCTTTTATATAAGACTTTAATGC GATACTATAAAAAGAAATGGAATGGATTC ACAGACTCTTGGAAATTAATTTACATATA CTTTCAACCAAGAACATCAGCACTGCATA AGACAAACTATTCACAGCTTCAGGAGAG CTAAGAAGTAAAGTACTGGCTTAACACAG AAGGCTGGGTTCTCAACAAGCACTGCCT AGCCCACAGAAGCCACCGAATATCA TGGAAACTATCCATGTGTGTGCACTC rs4699343 99803666 TTCTATGGCCAGGTCTGTTAGTTTACGTA C/T GGGTTTTCTTTGGGTACTCTGGTTTCCTC SEQ_0182 K*

O GCTGCACAGTCACTTCTCTGGTATCTATT CCACATCCCAAAGATGTGTGCATTAGGT ACTATTTCAGTCAAGCTTCTTAAATTAGAT GAACCGAACTGAAGTGTCCACACGGTCC TTAAAAGGGAAAGAAACAGCTTTCCTAAA CTGTCTGAGTGAGTGTGGATGTGTGATG TTAAATCAGTTCCTTTAAATGAGGTTGAC GAATGGTGTCCTGTCTAGGGTGGGTCCC CCTTGAGTAGGTAATTTGTGTAAACATAA TGCCTTGTGCCCTGATATGCCAGGACAG AATGGGTCCTGCTCTTCCTAAAATCTTAT ACTCCAGCCACTCTCAACCCTGAACTAAA CACTAGGTTCTCAAAACTGGGCTCCAAAT ATCATGGAATCATTGAGTAAATAATTATTT GTGAGATGTGGTGTACAGCAGGTCTTCG TGTTTTTATTAATCCTTTCTCTTGTTTTCG AGAAATGTCATTTTGTTCAATGTCGTTTC AGACAGAGTCTTGCTCTGTCCCCCAGGC CTTCAGTAACATTGATGAGAGGCCGGGG TGGAGTGCAGTGGTGAGATCTCGGCTCA CCATTGTGCAGAGTTTGCACATTTGCCC CTGCAACCTCCACCTCCTGAGTTCTGTAT CACGTCTGCA ATATAGCTCACATTTATTTCAATGTTTAAT ATTAAAAGTGTTTTGAATCTTTACTTAGTT TGCTGATG I I I I I GTGACCAGAAATATGT CCTAGCAACTTCAACTTTTGTCTGTATCA AGTAGCCTATGGTAAAATTAGATTTCTTA TACATACATGTCATTTTGCTTAAAGTCAC AGTTTCCAAATAGATGATCTTAAGTGAGG ACTTACTGTATCTGTATAATTAAGATATAA GTATTCCATTCTTGTCTGTATACTATTTTC TCATTGTAGATGAAAGGCTCTATATGAAT AAAATACTGCATATAAATATACTCACATAT AGAATCTACAGATCACCGTGTACATACAC AGAAACATCAAAGGTGTCCTAGGCTATAA AGTGCAGGTCTCATAGGCTAAAATCATTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10002696 4 99807848 CCTACTACATATCTCCATTTGGTTACTAC C/G GACAACCACTGAAGTAAACACCATATCGT S EQ_0183

TCATTCAACTAAAGCATGTGCCCTCGAAA CACTTTCCAACTGTGGAAACTGAGCTTAC ATCAATGAAATTAGAGACTTTTCTTTCCA GAGACATTAAGTAGCCTGGACTAGAGTT GCTGGAAGGGTGTAGCAAGCCTGATTTG GCTACCTACCTAGTGACTGGGAAAACCC AAAATGATTACAACTGCTTCTACAGGGTA CAATTCAAACCCAGGCATCTGACTCCAG AAAAACTGCCCGAAGTGGGCATTGAGTT AATCCCGACCACTCCAAATGCAGGATGA TAAACATTATATCCTCGTCATTAATAAAAA GAAGATCTATTGGCAATACAGTTTCTCCT CAAGAGCTAACATTTATTGCATCCTTACA CACTGCGTCTCAGAACTTGGGGATTCAG ATGGAACTGGCACAGTTACGAACTTGTG TTTCATTTAGACTTCTGCAGCCAGTTTAA TCATTTCAATAAAGTTTCA TCTCTAACCTACTCATCTTGTTTGGTTGG TTAAGAGATGTTATACAGCCACAAAATAA CACAAGATCTGTAATAATTCAGAATCTTT TGGC rs 10025051 4 99807964 CCTACTACATATCTCCATTTGGTTACTAC A/G ATTCAAACCCAGGCATCTGACTCCAGAAT SEQ_0184

TCATTCAACTAAAGCATGTGCCCTCGAAA CCCGACCACTCCAAATGCAGGATGAGAA ATCAATGAAATTAGAGACTTTTCTTTCCA GATCTATTGGCAATACAGTTTCTCCTCAC GCTGGAAGGGTGTAGCAAGCCTGATTTG TGCGTCTCAGAACTTGGGGATTCAGTTT K>

O AAAATGATTACAACTGCTTCTACAGGGTA CATTTAGACTTCTGCAGCCAGTTTAATCT AAAAACTGCCCGAAGTGGGCATTGAGTT CTAACCTACTCATCTTGTTTGGTTGGTTA TAAACATTATATCCTCGTCATTAATAAAAA AGAGATGTTATACAGCCACAAAATAACAC CAAGAGCTAACATTTATTGCATCCTTACA AAGATCTGTAATAATTCAGAATCTTTTGG ATGGAACTGGCACAGTTACGAACTTGTG C TCATTTCAATAAAGTTTCAGGACAACCAC TGAAGTAAACACCATATCGTCACTTTCCA ACTGTGGAAACTGAGCTTACGAGACATT AAGTAGCCTGGACTAGAGTTGCTACCTA CCTAGTGACTGGGAAAACCCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10006366 4 99809387 GATGGGATGTGCATTGGACTTGGGAATA C/T TCTAI I I I IATTTATTC I I I I I IAAATTATA SEQ_0185

AGGGAATGGGAGCTAAACTGAGACACAG CTTTAAGTTCCGGAGTACATGTGCAGAA ATATTTAGAATCAACAAAGATTTTAGAGG CTTGCAGTTTCATTACATAGGTATACACA TTGTCTAGTCTAG I I I I I I CATTTGCAGA TGCCATGGTGGTTTGCTGCACCCATCAA GTAAACTAGAGCAGTTATTAGATTCACTT CCTGTCACCTACATTAGGTATTTCTCCTA AAGATTACACAACATATACACACATATTA ATGCTATCCCTCCCCTACCCCCTACCCC TACACACACACACACACACACACATATTT ACGACAGGCCCCAGTATGTGATGTTCCC AGAAACAGGATCTTACTCCATTGTCCAGA TTCCCTGTGTCCGTGTGTTCTCCTTGTTC CTGGAATGCAGTGGCAAGACCATAGCTC AACTCCCACTTATGAGTGAGAACATGCA ACTGCTGCCACAAACTCCTGAGCTCAAG GTGTTTGGTTTTCTGTTCTTGTGATAGTT CCATCCTCCTGCTTCATCCTCCTGAGTAG TGCTGAGAAAGAGGATTTCCAGCTTCAT CTGGGACTAGGGGCATGTGCCACCATAC CCATGTCCCTGCAAAGGACATGAACTCA CCGGCTAAATGTTAAAA I I I I I I I AAAAG TCC I I I I I IATGGCTGCATAGCATTCCAT ACGGTCTCACTATGTCGCCCAGGCTGGA AGTGTATATGTGCCACATΠTCTTCATCC GTATAGTGGCATGACCATACCTCACTGC AGTCTATCACTGATGGACATTTGGGTTG TGCCTCAAACTCCTGGTATTATATAATCT GTTCCAAGTCTTTGCTATTGTGAATAGTG TTCTGCCTCAGCCTTCTGAGTAGCTGGG CTGCAATAAACATACATACATGTGTCTTT K>

O ATTACAGGCACACTT ATAGAATGATTTA rs4699644 99814723 GTTCTTCTTTAAACTGGTTATTCTAGTTAG C/T CTGCCAGATGCCAGCCAGAGCTCTCCTG SEQ_0186 CAATTCGTCTAACC I i I I I I CAAGGTTCTT TATGAGGTGTCCGTCGGCCCCTACTGGG AGCTTCCTTGCATTGGGTTAGAGCATGC AGGTGTCTCCCAGATACACAGGGGTCAG TCGTTTAGCTCAAGTCTGTTATTACCCAC GGACCCACTTGAGGAGGCAGGCTGACC CTTCTGAAGCCTACTTCTGTCAATTCGTC CTCAGCAGAGCTCAAACACTGTGCTGGG AAACTCATTCTCCATCCAGTTTTGTTCCC AGGTCCGCTGCTCTCTTCAGAGCTGTCA TTGCTGGTGAGGAGTTGTAATCCCTTGG GGCAGGGACATTTAAGTCTGCTGAAGCT AGGAGAAGAGGTGTTCTTG I I I I I GGTAT GCGCCCATAGCCACCCCTTTCCCCGGGT TTTCAGCC I I I I I CAGCTGGTTTCTCCCC GCTCTGTCCCAGGGAGATGGAGGTΠTA ATCTTTGTGGATTTATCCATCTTTGGTCTT TCTATAAGTCCCTGACTGGGGCTGCTAC TAATGTTGGTGACCTTCAGATGGGGTCTT C I I I I I GTCAGAGATCCTCTGCCCAGAGA TAAGCAGATGTGCTATTCCTTTCTGTTTG AAAGAAATCTGGCGGTCTGGCCCCAGCA TTAGTTTTCCTTTTGGCAGTCAGGCCCTT GCCTTTCTGAGCTGCAGTGGGCTCTGCC CTGCTGCCGGTCTGCTGGAGTTTGCTAG CAGTTCGAACTTCCCAGTGCCTTTGTTTA AGATCCACTCTCAGCCCTGTTTGCCTGG AACTGTGAATGTAAAACCACCTACTCAAG GTATCACCAGCGGAAGCAAAGATTCCTG CCTCAGCAATGGCGGACGCCCCTCCCC CCTGATCTTTCCTCAGGAAGCTTTGTCCC CGACCAAGCTCTAGTGCCCCAGGTGGAG AGAGGAGCA CTCAGACTGCTGCCGTGCTGGCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2037832 4 99816706 TGCTGGCAAATCCCATGCTCTCAACATGT C/T ACCAGCAGTACCAGTTCACTACATCAGC SEQ_0187

GCCTCACCGCCCTCCCAGAGAGCTACTT TCCTTAGTCCACAAAAAGGTCCACAGGA

CAAGAGCTGATGCTCAGGCCTCCAGTAT TGGACAGGGACAGAGGCCAACAGCCAC

TTGCTGTCTGCATTAGGAGGTGGCAAGG CCCGCCACCAGAGCAGGGCCATTCCTCT

GCCTGGCACAGAGGTCTGCGACAAGCC GACATCTAAGAGTCACATCCATATGACTA

AAGCTAGGCCATGGCTTCCATCCACACC CTGCAACCTGTGGCTCAAAGTCAGCTGA

CCTCTGCACCTAAATGCATTGATCCTACA AAAATGGTTATACACATTAAGTTAGAGCC

ATGAAGAGCTGGCAAGGTCATCCTGGTT ATTTTGTGAAAACTAATTCAGTTTTCTTCC

TTGCTCCATTTTCTCTGTGGCATTGTCAT CGTTGCTTGGTACATACACACTATTCAGT

TTGAGGTGCTGCTCATGGTAGGTGGTGG GAAATATTAGCTΠTATTCAAGGCATGAC

GGTTCACCTTCTTCCATGCTGAGCTAGG ATAGGAATTCCTTCAAAATTAATATTTTAT

CTGGACACATTCCAGCCGACAGCAGGAC GCTATACTTTGTATCAGTTTATACTGAAAT

AAAGAGGGTGATGTGACCACCTATGAGG ATTTATCAACATGTCCTGTGACTGCCTGT

GGCTCAGCcccATGCTCTGTGATCACGG GCAGGAATTTATTCAAATTTATTCCATTTT

CCTGGGGACTTTGGCACCTGAGGTGCTG GCTGTTTGTTGTATACTGATTTTCACTGA

GATGGTGTCACTACTGGGCACAGTTTTC

CCTGCATCAGCAGCAATAGGGGAATACG K.

TGCACACAGGAAGGCTCAGGTTCCCCAA S

ACTCATATAGCATCTGGACTAAAAGGAAG

GATTTGTACAGGGCTCTAGAGGTTAACT

GTCAGTTATGTAGTTGCTCCACTTTAGAA

CAATGACTTTGGACACTTTAGGGCATAG

CCAAAGAGCAAAGCAGTTACTTTGTGGC

TGTTCTGCCTGCTCCTCACTCTTGGCCAT

CAGTAAGTCTGGCTTAGGATGGAGAAAT

CCAAGGGTCTCCTCTGGCTGAGGGAGG

CAGGTCCAGAAAGCCACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6532742 4 99819712 CTAGACCCTTTCTAGTCCTAAGATTACCT A/C TGTGGGATAGGCTGGGCATGGTGGCTCA SEQ_0188

GGTACAGGCTTTACTCTGACTGCAGGAG CGCCTGTAATTCCAGCACTTTGGGAGGC AGATGTGGATTTGATAACACTAAGGTGGT TGAGGCAGGCAGATCACTTGAGGCCAG CCTTATCCACCAACCTTCCTGCTCTCTTG GAGATCGAGACTAGCCTGGGCAACATGG GCAAACTCTGAGAGGCTCATTTCCTGAAT AAAAACCCCATCTGTACTAAAAATACAAA GTTTCTCTCAGAAGATTACATATACACTA GAAATTAGCTGGGCATGGTGGCATGCCT CAATGCATCCTTTTCTTCCATAAGAAA ATAATCCCAGCTACTCAGGAGGCTGAGG CATGAGAATTGCTTGAACCCAGGAGGGG GAGGGTGCAGTGAGCCGAGATCATGCC ACTACACTCCAGCCTGGGTGACAGAGCA AGACTCTGTCTCAAAAAAAAAAAAAAAAA AAAAGAGAGAGAGAGAGAGAGAAGGAAA ATGGGGGTTAAATCAGGAAACTAAACTTT ATGCCACACTTTCTTGGGTGCCTGTGAA GCAAATCACCTCACCCATCTGGGTCTTG GTTATCCTGTTGGGATATGCAGGGGATA CGTTAAGGTCATCTCTACCTCTAAAAGCC K> TAGACTCTAATTTTAGAGAGATATG O rs4699345 99823684 CAGTTGAATTATTCAAAGAAAACATCTAT C/T GTCAATCAGTAAATTCCTA I I I I I GCCTG SEQ 0189 GTAGGAAGTCTTATGTTCAGGGGAGGGA AGCCAGTTTGATTGGGGTTTCTGTCACTT TGGTGGAAGTGTGTGATGGGCATCTGCT AGAGCTGAAAATGTCCTAATTCAAAATGT GAGATGCCCCCATGGAGCAGCCCTCCTC AACTATCTAGCTGCAATATATATA I I I I I I CATTCTGACCTTGTGGCTTGAACAGGGC CATTTAACCACACTGCTTACTGTTCATGC TGAGCCTACAAGGCAAGTACATGACCCA TTTTGAACATAGGGATTATTTCTACACAT GGACATCTAATGACCAGTGCCTCTCATG AAGAC I I I I I I I I I I I I GAGACAGGGTCT GCTCCGTGACCGACAGTGGCAAGGAGT TGCTCTGTCACCCAGGCTGGAGTCCAGT CAGGAGGGGTGAGCTGAGCCTAGCCCA GGTGTGATATCGGCTCATTACAACCTCT CCAAAGTCCATGTCCATCAGATGCAAGA GCTTCCTGGGCTCAGGTGATCCTCCCAC CTAAGCTGAAATTACCAGAGAAGAGGGT CTCAGCCTCTCAAGTAGCTGTGACTACT TTTTCTTCCTGCTAGTGAAACAGAAACCT GGCGTGTGCCACCACACCTGGCTAATTT AGAGCAGCTGGTGGCTGTTTCTGCCACT CTTTGTA I I I I I I GTAGAGGCAGGGTTTC GCTTGGGGGCAAGCTTGCCTGAAAAAGA ACCATGTTGCCTAGGCTGGTCTAGAACT AGCCAACAGAGAAAGGCAGAGCAAGAAA CCTGGCCTCAAGCGATATGCCCACCTCA TGAAGAGAAAAACTGCTGATACCTTCAGA ACCTCCCAAAGTGCTGGGATTACAGGCG GCAACTGGAAATGGCCAATGCCAAAAGC TGAGCCAGCACACCCAACCCACATATTC AATATCCCTAGATGTTTCTGTTA TTAATAGGCTCAACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6831643 4 99833465 GTGGGGGTTGGGGAGAGGAAGTGACAT CfT GTGATCTGGGTGCTGGTTACAGAGTTTC SEQ_0190

GAGTATAAAAATCCCACAGAAAGATACTC TTCAGTTTGTGAAAATCCATCAGTATGTG TGCTTGGAGCTAGAAGTGTTAGGCCTTG CACCATACGATACTTCATAATCCCTAAGG GATGGTAATAGAAGAAATAGCCTGAGAA ATCTCTGTGCTCTCCTTTCTACCAACTCT CACCAGAAGTTTTCCTAAAGCAAGGCCC CCAATTTCACATCATACCACTCTCTCCAG TGAAATGTGAACACAAGAGAGCTAACAG TCACACAGGCCTACTTTCTATTCCTTGAC CGTGGGTGGTTACTGCTTCCAGCAGCCC TATATCAAGCAATTTTTGACGTCAATCAT CAATGGTACTGAACATGTCCAACTT CCTGCTAATTGCATCTCTTTCTTCTCTCC TTTATAAAGACAGGGTACTCCTACCCTAA GGGTTTGTTTGAGATGATAACTCAGTAAA GTCTTTTCTGGCCACCTTTGCGAATTTAT TCCCCCCTCATATTACTAACCACACTTCC TGAAATTATTCCTTCTAATTATATCTGTAG TTG I I I I I CAGCTGTCTCCCCTAGTAGGC TGTATGCATCATGAGAATGGAGACCATG TCCATCTTATCCACTTGTGTTTCCCCAGC ACAGTGCCTTGAATACAGAAGGTATTAAA AAAAATTG rs4699348 99833656 TGAGTATAAAAATCCCACAGAAAGATACT C/G ACGTCAATCATCCTGCTAATTGCATCTCT SEQ_0191 CTGCTTGGAGCTAGAAGTGTTAGGCCTT TTCTTCTCTCCTTTATAAAGACAGGGTAC GGATGGTAATAGAAGAAATAGCCTGAGA TCCTACCCTAAGGGTTTGTTTGAGATGAT ACACCAGAAGTTTTCCTAAAGCAAGGCC AACTCAGTAAAGTCTTTTCTGGCCACCTT CTGAAATGTGAACACAAGAGAGCTAACA TGCGAATTTATTCCCCCCTCATATTACTA GCGTGGGTGGTTACTGCTTCCAGCAGCC ACCACACTTCCTGAAATTATTCCTTCTAA CCAATGGTACTGAACATGTCCAACTTCGT TTATATCTGTAGTTG I I I I I CAGCTGTCTC GATCTGGGTGCTGGTTACAGAGTTTCTT CCCTAGTAGGCTGTATGCATCATGAGAA CAGTTTGTGAAAATCCATCAGTATGTGCA TGGAGACCATGTCCATCTTATCCACTTGT CCATACGATACTTCATAATCCCTAAGGAT GTTTCCCCAGCACAGTGCCTTGAATACA CTCTGTGCTCTCCTTTCTACCAACTCTCC GAAGGTATTAAAAAAAATTGGCTGTATGA AATTTCACATCATACCACTCTCTCCAGTC ATGATATTTCCCAACCCCTTAAGTTTTCA ACACAGGCCTACTTTCTATTCCTTGACTA GGTATTATGCTAAAAGGGTAAATATAGAA TATCAAGCAA I I I I I ATAAGTAAACAAGTAGTTAAAAATTAAAA

ATTAGCTTGAATACAAATΠTCAGACTGC

TTTCATGTGCCTTGCTTTACCCACAACCA

GCGGTAGCAGCTTCATGGCACTAATGAC

AAAACAATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS6837359 4 99833736 TGAGTATAAAAATCCCACAGAAAGATACT C/G AGATGATAACTCAGTAAAGTCTTTTCTGG SEQ_0192

CTGCTTGGAGCTAGAAGTGTTAGGCCTT CCACCTTTGCGAATTTATTCCCCCCTCAT GGATGGTAATAGAAGAAATAGCCTGAGA ATTACTAACCACACTTCCTGAAATTATTC ACACCAGAAGTΠTCCTAAAGCAAGGCC CTTCTAATTATATCTGTAGTTG I I I I I CAG CTGAAATGTGAACACAAGAGAGCTAACA CTGTCTCCCCTAGTAGGCTGTATGCATC GCGTGGGTGGTTACTGCTTCCAGCAGCC ATGAGAATGGAGACCATGTCCATCTTATC CCAATGGTACTGAACATGTCCAACTTCGT CACTTGTGTTTCCCCAGCACAGTGCCTT GATCTGGGTGCTGGTTACAGAGTTTCTT GAATACAGAAGGTATTAAAAAAAATTGGC CAGTTTGTGAAAATCCATCAGTATGTGCA TGTATGAATGATATTTCCCAACCCCTTAA CCATACGATACTTCATAATCCCTAAGGAT GTTTTCAGGTATTATGCTAAAAGGGTAAA CTCTGTGCTCTCCTTTCTACCAACTCTCC TATAGAAATAAGTAAACAAGTAGTTAAAA AATTTCACATCATACCACTCTCTCCAGTC ATTAAAAATTAGCTTGAATACAAATTTTCA ACACAGGCCTACTTTCTATTCCTTGACTA GACTGCTTTCATGTGCCTTGCTTTACCCA

TATCAAGCAA I I I I I GACGTCAATCATCC CAACCAGCGGTAGCAGCTTCATGGCACT TGCTAATTGCATCTCTTTCTTCTCTCCTTT AATGACAAAACAATAAACCAACAGCTCCT ATAAAGACAGGGTACTCCTACCCTAAGG CAGTAATC GTTTGTTT K* rs 11730384 4 99834522 GGATATCCTTAGCAAAAGCAAAGCTACTA A/G AAAGTCAATTCCATCCTTCCTGTAGAAGG SEQ_0193 K*

ATTCATTCTTTTCTCCTCCCTGCAAAAAG ATACACAGATGATTGTTATACAACTTTAG ACTGAAAAATCACTCCACACACGCGCGC GATGACCCATGCTTTCCTGTCTCAGGAA GCACACACACGTGCGTGCGCACACACAC GCTCCCAGAGACTCCCTAACTGCATCTC ACGTGCACAGCACACACCCCCACACACA ATTCACCCACGTGGTGGGTTTCAAACTT CAGCACCCCCACACACACACACACACAC GCTCTGATGATAAAGCACTGGGAAGCAG ACACAGGTAGGAATGGCTCTTCAGCACT AGCTGCCTATTGAGGAAAAATATGAAACA GAACTGGCATCTTCACCTACTACCCAAAC C CACTGGGACTTCACAATCCTTACACACTG TCTTGGCCCCAGATGCAGAGACATTTTAT GCCAAATCTGTGGGTGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS13141997 4 99835934 ACACACTCGGGGAGGAATACAAATTCTA C/T GGGAAGGGCAAAATTCCCCATTCCTTAT SEQ_0194

CAGTCTCTGAACTAGGCAGGGTGGCTGC GCAAGGGCTGTACGTAGTGGCCTCCTTC AATTTGGGAAGCTG I I I I I I I CCCTTAGG CAAAGGAGGTGGGCCGAGTCACTTTACA TAGAATAAAATGTTCATCAGACCACATTT GTGGAGAAATCTGGCAGCGGATTGCATC GTAAGTATTCACTCAATAATGAATACAAC GGCCACGTGATCAAGATTATGTTGACAT AGTAACCATΠTAACATCCAAGTAGI I I I I GATCACATCAGTGATAAGTCATGTTGACA AAAATCACACACTTAGAAATACAACTGAG GGATGTACCCCTGATACAACAAAAATGG AATTCCAAATAATTTATGTAAATATTCTGC CACTTAACCTCTGTGGGTCTTCCCCTAGT

CCACAAC CTAATCATGAGAAAAACAACAGACAAATC TGAGGAACATTCCACAAAATACCTAAACA CTATTCCTCAAAACTGTCAAGATCATCAA AAACAAAAAGGTCTACGAAACTGTCACA GCCAAGAGGTGCCTAAGAAACCATGAAC AACGTAATGTAGTGCCCAGGGTGAGATC CTGGAACAGAAAAGGACATTAGGTAAAA CCTAAGGAAGTCTGAATAAGGTACAAACT TTAGTTAATAATAATATATCAATATTGGCT K* CATTAGTTGTAACAAA rs10018825 99836081 ACACACTCGGGGAGGAATACAAATTCTA A/G TCAGTGATAAGTCATGTTGACAGGATGTA SEQ_0195 CAGTCTCTGAACTAGGCAGGGTGGCTGC CCCCTGATACAACAAAAATGGCACTTAAC AATTTGGGAAGCTG M I I I I I CCCTTAGG CTCTGTGGGTCTTCCCCTAGTCTAATCAT TAGAATAAAATGTTCATCAGACCACATTT GAGAAAAACAACAGACAAATCTGAGGAA GTAAGTATTCACTCAATAATGAATACAAC CATTCCACAAAATACCTAAACACTATTCC AGTAACCATTTTAACATCCAAGTAGTTTTT TCAAAACTGTCAAGATCATCAAAAACAAA AAAATCACACACTTAGAAATACAACTGAG AAGGTCTACGAAACTGTCACAGCCAAGA AATTCCAAATAATTTATGTAAATATTCTGC GGTGCCTAAGAAACCATGAACAACGTAA CCACAACTGGGAAGGGCAAAATTCCCCA TGTAGTGCCCAGGGTGAGATCCTGGAAC TTCCTTATGCAAGGGCTGTACGTAGTGG AGAAAAGGACATTAGGTAAAACCTAAGG CCTCCTTCCAAAGGAGGTGGGCCGAGTC AAGTCTGAATAAGGTACAAACTTTAGTTA ACTTTACAGTGGAGAAATCTGGCAGCGG ATAATAATATATCAATATTGGCTCATTAGT ATTGCATCGGCCACGTGATCAAGATTAT TGTAACAAATGCAGTATATTAACATGTAA GTTGACATGATCAC GGTGTTAGAAATACTTGTTCCCCGGTGA CGCAAAGAAACAGCACTCGAACATAAATT TAATCATCTTAGCAAGGCCA I I I I I ATTAA ATGTATGTTCGAATGCTCATACATTTATTT CTCTGCAGCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS13149070 4 99836862 TAAGGAAGTCTGAATAAGGTACAAACTTT C/T GGTGGCACTTGAAGAGATTGGTTTGCCA SEQ_0196

AGTTAATAATAATATATCAATATTGGCTCA ATCGATGGGCTGCTTTTGAGGCTCTTGA TTAGTTGTAACAAATGCAGTATATTAACA TTAACATATGTAGAGTTCCAAAGTGCCTT TGTAAGGTGTTAGAAATACTTGTTCCCCG GAAAGCTTTCTATTATCTCAGCACTCCAA GTGACGCAAAGAAACAGCACTCGAACAT ATGCAGTTTCTAAATGCTGATATTCAGTT AAATTTAATCATCTTAGCAAGGCCA I I I I I TCAGC I I I I I CCAGTTTCTTCTTCAGCCT ATTAAATGTATGTTCGAATGCTCATACAT TCCACATTCATGATCACCTGTTCACCCT TTATTTCTCTGCAGCACCAGGGAACAAG CATTTCTAACATAAGGTGTTAGTAACAGG GGAAAATGGGTGCACAGTAAATGGAAAC TGTACTATCTTTGCAACTTTCCTGTAAATA TAAAACTCTTCCAAGTCTCACACTGTCCC CCTGGATCTCAATCTGCTGGCTAAGTAAA TCCATACTGAATTTAGAACAGAGATTATT AGGCAAAAAGTΠTTAAAGTTGCAGCGAA GGGAGGGTAAACGGCTTGTGCACCGCT GCTAGCTAATATCCACAGCTTCCCCAGG GACTTTAATG

RS2866017 4 99837966 CAAAGTCATTAAGTGGCATTTGGACTAAA C/G GAGCCTACTTATGTTATGGAGTATTTCCA SEQ_0197

TCTGATTGGAATTTAGAATCTACTTGGAG ATAGTGGTTATTAAAGTAATTCAAGGAAA ACAAACAAAATATACTTCTGCTTAGAAAA ATCAGTAACTAATGATAATAAAAAAGTTG ATTACATTTTCCACTTTAAGATGTTGTGG CCTTAAAATAGTGTTCAAGAAAATAGAGT ATTAGAAAATGATAAGAATTAATTTTAAGA GTGTATGTCATATTTTAGCACATAGAAAG

GAACGCCTG I I I I I I GAAAGGATTGGTTA GCTTAAACCCTCTTGTGAACTCCTACTTA

TATGTTGGTGGAAATTCTTCAGGGAAGT ACCATTTCTTTATTATACTCTTCTTACTCA

GACATCTCTGGAGGGGGAAACACAAAAA GATTTATAAATTTTCCTTCCTTTCTGCAAA

CAGCTCAATACAGTCAGTCAATTTATTCT AAGACAGAGATAAATAAAGATACTAACTT

ACACTTAAGGAAAAAATAACTAAGTCTGC TTCCCCGTCATTATATCACCCCATTACCC

TTGCTGGTTTTCTGTGGGCTGTTAACAGC TGTTATGACAGTAATATTCATGTTGAATAT

TGGTTGACTCAAATTTCTGCTTTCTACCA CCGGTCATGTTTAGCCATTTGTATTGTGT

ATTGTGAAAATTAAGCTTTAATTTAGAGG TTAAAGTTA I I I I I I ATGATTTCCAAATTT

AGCACCTGGATGTTGAGACTCTGTCTGA GAAATACTGGAAAGGAAGATCCCAGCCT

AGATACAGGGGCTAAAAATGTTCAGATTC GATGGAAA I I I I I ACCAGAATAGTGATTC

TGTCTGAAGATACAGGGGCTATGGCTTG C I I I I I GCTGTAGAAAACATGGGAGGGA

TCTATGGTTACAG I I I I I GCAAATGCAGA AATTGTCTTAGTGTCGTTACTGTCTAG

AAAGCTTTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS13137132 4 99838949 AAACATATTTAATTGCTTCTAAATGCTAAG A/G GATAATCCTTGAAGACAAGTGCCAGGCA SEQ 0198

CACAGAGAAATAAAATTGAATGAGATTGA CTCTTCTAGATTCTGTAGATAGAACAATG

AGAGACTAATATCTTCAATTGAGGGAGG AGCAAAACAAATGCTGTGCCATCATGAC

CAGGGGGCGTGTΠTCCTTGTTTAGGAC ACTTACATTCCTGTGCAGGGGAGCACAA

GTGCCTCCAAGGCCTGTCTAGCATGAGG TAAACTAAACTATATATATAATATAATGTG

CTCCGCTCAGCAAATATTCACTGAAATGT TGACAGGGGCTCTAAAGTAAAAAAGGCA GAACAACAAAGCTCTGCCTTCAGGATGT GTGTAGGAAGATGGGGAGCTTTTCCAGA

CTGAGTGGTCTTACACTTGGAAGAAGTTT

CAGATGAGCTGAGATTTAAATGAAGTGA

GTGGCAAATGTTGCAAATATTCTAGATAA

AAGTGTTCTAAGCAGAAGGAACTAATTAA

TATGCAGGCAACTAACGATAACACAGTTT

GCAGCTAGTATAATGAGGTATGTGGCCG

AGTTTGGTAGCTGTCTACCAAAACTCCAT

TTTGTCTTTCTGGTCACCCAGCTAGACCA

CATGTCTCAGCTGCCCTTGCAGTTTGAG

TGGCTTTGTGACTTGTCTTTACCAATGGA K>

CTGTGAGAGAAGTG Ul rs7672134 99839510 AAAACAAATGCTGTGCCATCATGACACTT C/T TTTACCCTTTCACATAAAACGGAACACAA SEQ_0199 ACATTCCTGTGCAGGGGAGCACAATAAA TGGGGCTAGCAGAGCCATMCGTGGAAA CTAAACTATATATATAATATAATGTGTGAC GGGCCTGGGCCTATACATCACTGCAAAA AGGGGCTCTAAAGTAAAAAAGGCAGTGT AGGACAGTCATCCAGGCTCACGCCTATA AGGAAGATGGGGAGCTTTTCCAGACTGA ATCCCAGCACTTTGGGAGGCCAAGGTGG GTGGTCTTACACTTGGAAGAAGTTTCAGA GCGGATCACCTGAGGTCGGGAGTTCAAG TGAGCTGAGATTTAAATGAAGTGAGTGG ACCAGCCTGACCCAACATGGAGAAACCT CAAATGTTGCAAATATTCTAGATAAAAGT TGTCTCTACTAAAAATACAATATTAGCAG GTTCTAAGCAGAAGGAACTAATTAATATG ATC I I I I I CCATTGTCATATCCCTAGGAC CAGGCAACTAACGATAACACAGTTTGCA CTGGCACAAATCCTGGAAAATGGTAGAT GCTAGTATAATGAGGTATGTGGCCGAGT ATTCAGTATTTATTGAATAAATGCTACTGA

TTGGTAGCTGTCTACCAAAACTCCATΠT AAGCATGAAAAAAGCAAGTAGGTCAATAA

GTCTTTCTGGTCACCCAGCTAGACCACA GTAATTGAGGCAAGGGTTCAGCAGGGGT

TGTCTCAGCTGCCCTTGCAGTTTGAGTG TTATGACAGCGACACTTTAAAGAATGGG

GCTTTGTGACTTGTCTTTACCAATGGACT GCAAGTGGCTTATAAGGGCCTGGTAGGA

GTGAGAGAAGTGGTAGGTGTCACTTCTG TGGTTGGGGTGGATATTCTTGGCAGTGG

AGGCAAGGCTTTAAGAAACAAATATATCC AAAGCGTATAAGCAAAGAAAGGAAGAAA

ACTCCATGCTCTCTT ATACATGACACATTTGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10021296 4 99840416 GCCCTGGTGAAGAGGAAGCTTGAAGCAC C/T GCAGATTTTGAATGCCTAGACATTTGAGG SEQ_0200

ACAACACAAGGAAGACATAAAAAGAAGA GGAGGGGATGAGGTTATAAATAAGGCTA

GTGGTAATGCTAGTGGGGTCACTACACC TAAAGGAGGCATAAACTATGGCATAACA

GTCGCTGCGTCCTGAAATTCCAGCAGAC GAAGGAATTCAAAGAGCTCTGATGGGAA

ACTGTCCAGGAAGATTAGCTGTGGGCAG ACAGTAAGGCCAGATTTGTGTTTTACAAG

GCACATTCCAGCAAAGGTACGAAACAGC AGCATTCTAGTTGAAACATGCTTGAAGG

ATGGCAGCTCACAGAACTGCGAATAGTC GGTGTGATACCTGGACAGGAAAAGCAGG

CAGCCCCCTCAAAAGTAGGCTCCATGAT TAGTAGATGACTGCAATGGCCCAGGCCT

GGCAATGACTTTGTTTTATTCACTGCTGA

GTCTCCAGTGCCTAGAACAGGCCCTGCA

CTT rs4699349 4 99844135 CATCCCATTGCTCTGTATTAAATTTGGAC C/T ACATGCTTCACCTGCATGCCCCATTCAG SEQ_0201

TGCTTAAAGTAGGAGTTATATATACTTGT ACAAGAACAGATGCTGCTGCAACAAAGT

TATGGGGACCAAAAAGCTGCCTGGAATT GGTCCAACCACAACAAACAACACTTCTCT

TTGTAGCCTTTATCACAAGCAGCTGAGA GTGAGCCATGTTATGCCAAAGCCTCTGC

GGCTGTCTGAGAGTCACATAAGTAGATC AGGCACAGATCATGAAGCAATTTAATACA

ACAGCTGCCAATGGTCAGTCCAGGTGCC AGCTTAGATAAAAAGCCAAGTGAACAATC £

TGTGTTCCCTCC I I I I I CAGTGGCCTAGA TAGAAGCCAAAAGAAAACACAAGGGAAA ^

G G rs1534555 4 99845490 ATACAAATACTGGAGCTGATTGTAGCAGA C/T GTAACCTGTTGGGCCTATGAGGACGCAG SEQ_0202

AACAGCTGTGCTGCAGCCTACACGGCCA AAGTGCAAAATACATTCCCTGCCCTCAAA

AGTGCAGGAGACGCTGGCATGATGTCTT GGGTTTATTGTCATCTAGGCCCGATGGT

CAAGAGGGTGCAGGCTCCCGAGTAGTG TCCTTCCAAATTGTGGGTAGCCTCCTACA

CAGCTACAAAGCTGCCCCCCAGGGTTTA GTGGATAGTCAAAATCAATTAAATGGGTC

ACTGGCCAATTCTTGCAAAGGGGCACTC AAAATAAACACTGTΠTTAACACACACAA

AATAAATAATTTGAAATTTGAATAAGTCTC AAAAAGAAGAAAATGTTCCTGTGGAACTC

TCCATCCTGCCTACTCCCAGCACAAAATC TTAATTAAAATGTATGTGCCCATCACAAC

CATCAACAGACTGGATCTTCT ATTAAAATATATTCCTTACTATGGGACAA

ATTAAAAATAATTTCAAAAATAACTGATTA

CTGAAGAAACCAGGCACATCTAACCATTT

ACAAAGAACTTTTACACAATTGGTTTTAC

AGAATCCAGAAATCCCAGGATCCAGCTA

TCATTATTATGCC I I I I I I CAGTGGTTCG

GAGATGTGGCTGCCTTGTTCAAAGCAAC

ACAGCACGGTTGGGATGTAATCGCAGAT

GGGTCTGCCTCCAGTATGTCCTCAAGTA

CCACAGGAGGTCAGAGAAGATGATGGTG

AGCAATGAGGGCTAGACACAAAAGGAGA GAGAGGAAACCTGAAAGGGGCCTGGAA AGGCAGGGAGGACTTTGGCCAGGGCAG TGGGTCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs 1573478 4 99845547 ATACAAATACTGGAGCTGATTGTAGCAGA A/G GGGTTTATTGTCATCTAGGCCCGATGGT

AACAGCTGTGCTGCAGCCTACACGGCCA TCCTTCCAAATTGTGGGTAGCCTCCTACA AGTGCAGGAGACGCTGGCATGATGTCTT GTGGATAGTCAAAATCAATTAAATGGGTC CAAGAGGGTGCAGGCTCCCGAGTAGTG AAAATAAACACTGTTTTTAACACACACAA CAGCTACAAAGCTGCCCCCCAGGGTTTA AAAAAGAAGAAAATGTTCCTGTGGAACTC ACTGGCCAATTCTTGCAAAGGGGCACTC TTAATTAAAATGTATGTGCCCATCACAAC AATAAATAATTTGAAATTTGAATAAGTCTC ATTAAAATATATTCCTTACTATGGGACAA TCCATCCTGCCTACTCCCAGCACAAAATC ATTAAAAATAATTTCAAAAATAACTGATTA CATCAACAGACTGGATCTTCTCGTAACCT CTGAAGAAACCAGGCACATCTAACCATTT GTTGGGCCTATGAGGACGCAGAAGTGCA ACAAAGAACTΠTACACAATTGGTTTTAC AAATACATTCCCTGCCCTCAA AGAATCCAGAAATCCCAGGATCCAGCTA

TCATTATTATGCC I I I I I I CAGTGGTTCG GAGATGTGGCTGCCTTGTTCAAAGCAAC ACAGCACGGTTGGGATGTAATCGCAGAT GGGTCTGCCTCCAGTATGTCCTCAAGTA CCACAGGAGGTCAGAGAAGATGATGGTG AGCAATGAGGGCTAGACACAAAAGGAGA K* GAGAGGAAACCTGAAAGGGGCCTGGAA AGGCAGGGAGGACTTTGGCCAGGGCAG TGGGTCA rs7678323 99846346 GGAAAGGCAGGGAGGACTTTGGCCAGG A/C ACTGCTTGGGCTCAATATATGATAGCTTA SEQ_0204 GCAGTGGGTCAGAGAAGTAGAAACGAGT AAAAAAAGGAGTCACATCACCTACGCAG TCAGTTAGTTGTTGGCGGTGGTGGCGGG AATCTTGCACCAATAGAGAAAATGAACAC GCGGGGGGCCTGGTCAGGCGAGTGTTC TTGTCACTGTATTTGGCCCTCACAACAAT AGTCCAATATAGCCGTGGGTACTGGAAG CCTATGAGATAGGCAAGATGGG I I I I I A TTCAGAGCAGACTAAAGGGATTAAACAG GAGCTCAGGAAACTCCAGCAGACAGACA ACTCATCTGGTCTCCATCAGTCCTGAGA GAATGACTTATGCTGGGGCTTCTGACCC CTTCTCTAGCCTCTTTGAGTTTCACTTTC AGTCCTCTTATTCCACAGGGAAACAAGTA TTCATCTGTAAAATGGGGATGACAACAG GAAAATAAGTCTGGAGGCCAGGCACGGT GATCTACTTGAAAGGACTAAATGAAATAA GGTTCCCGCCTGTAATCCCAGCACTTTG TACATGCA GGAGGCCAAGGCAGGCGGATCAAGAGG TCAGGAGATCGAGACCATCCTGGCTAGC AAGGTGAAACCCTATCTCTACTAAAAGTA CAAAAAATTAGCTGGGCGTGGTGGCACG TGCCTGTAGTCCCAGCTACTTGGGAGAC TGAGGCAGGAGAATCGTTTGAACCCAGA AGGCAGAGGTTGCAGTGACCCGAGATCA CTCCACTGCACTCCAGCCTGGGCGACAG TCCCCCACCCCCAGCCCACCACCAACCC ACCACAAAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2156504 4 99847490 GGAGAAGGATGCAGGCAGCTGAAGCCA A/T TTTGGCTTCCCACGAAGGCCTGACTACA SEQ_0205

ACTCACTTGGGGTATTCCCACTGGCAAG GGAAGAAAATGTGTACTAGATGTTCCCA CCTCCTGACTGTGAAATGGATGCCTCGG CACCAGAATCCCAGGCCATGAAATGGAA ACTTAACCTTGATGCCATCTGACACTTCA ATAGAAACAGTTCTATTCTCATTTTAAGG CTTCTCTTTG I I I I I ATTCCATACCAGCCA CAGTAAGCAGACAATCTGGTTTTATATAT AGTAAGCATCTGATTATG CCACTTCCTGAACTGGGATAACACGATG GAGAGATTAGCTCTGGCTAGGCTCATAA AATCAGTTTCTAAGCCTTGGTCCTCAGG GGACCAAGGATGTCCACTGGAACACACC GCCCTGCAGAACTCCTTGGGAAAACCCA CTCTGACCATCTGCAGGGACGTCCTATT AGAAGGGATGTGGGAGGCAGCCTGATCT GGCTGCGGCAGAGTGCAGGATGGCTGG GGGTGCTCGTGTCAGCAAGCTAGCTCAC AGGC rs7691465 99848365 AGAAAATTTGCTGAACCTGGATGTGATTT C/T ATCTAAAATAATGAACACCAAGAGAGAGA SEQ_0206 GAGATATGTTCATTTGAGATGACACCATC GAACAAAAC I I I I I CAGCCAAAGGAAATC K* AAAACTATACTCAGTCCAATGACTGGTTG AATTTTCTTTAAACAGAAGAATCAATGTTA 00 GGACCATGATAGGACCATATTCATTAGAT TCCTTTCATCTTCTTGAAGTΠTGAATTCA TGCTTGGTCACTCTATTCATTTCACAAAC TGGAAATGTTGA I I I I I AAATCAAACATC ATTTACTGAGTGTCTACAATGTACCAGAT AAAATCCTATCTAATTTTACTTCCTTTCAC ATTACTCTGCCTGTCACTAGGGACCCCT CCTATAAGTGGTAAAAAACAAAT GCCTTCAAGGAACTTACATGGTCCAGTG GTGTTGGCAGAGAGGTCAATTTACTATCA TAGTAAATATAGTAGGTTCTATGATGGGG ATGTGCACAGAGTCCAAAGGGAA rs7669964 99851756 AACAATTGCTAGAAGTTTCTGAAGGGGG AfT TAGAGTCTATGTTGCCCAGGCTGGTCTC SEQ_0207 CTCTTCTAGGAGACATTGGGTAAATAGG GAACTCCTGCGCTCAAGTGATCCTCCCA CTTAGGGCCTCCAAATTTTA I I I I I CCTC TCTTGGCCTCCCAAAGTTTTAGGATTACA TGTGGTTTGACCTCGTAATATGAAGAGAA GGCTTGAGCCACCATGGCCCAGCCGAAA AAACATACAAGCAAATATATCTTATAAAC TACCAACTTTTAAATCATAGTAACACTATT AGTTCTATCTATTGTCCATTGCATTTAAAA CTAAAGTAGATAACAACTACAAGAGAATC ATGCAAACTCATGAAATAACAACTΓΠTA TAAATCATCACTTGAAACTGTTTGAAAAC AATTTTGTATTTTGTACAG TGTCATCGAATACTATTTTGATTTATGAG AGCAAGAATTCTCAAACTGTTAAGTACTG ATCTTCTCACATCACCCACCAAGGACTAA ACAATCTTAATAAGAAGCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6532751 4 99854723 ATTAATTTCCTCTTTCCCCCTCAATTCATG G/T AGATTGTCTGAATATGTTGA I I I I IATCTA SEQ_0208

TACACAATCCACTTTGCCAACATATTAAA GATATTTTGATTTAAAAAATGTCATGGGG

CTTCAAATGTTTCAATTAACTCAAAATCAA CCATGAGCAGTGGCTCACACCTGTAATC

CCTGCAATGTTACAAAACTTAAACTTACA CCAGACAACATACTTTGGGAGGTCGAGA

TTGCTAAGTCTACAATCACCACAAATATT TGGGAGGATTGCTTGAGGTCAGAAGTTC

GCC I I I I I CAAAAAGGGAAAA I I I I IAAA GAGACCAGCTTGGGCAAAAAACTAAAAA

AACATAGTTGTATATCAACCAAAT ATTAGCCAGGCGTGGTGGCATGTGCCTA

TAGTCCCAGCTACTTGGAAAACTGAGGA

TGGAGGGTCACTTGGGCCCAGGAAGTC

CAGGCTGCAGTGAGCTGTGATGATACCT

AGGCAACAAAGCAAGACCCTGTCTCAAA

AAAAGGCCAGGACTAAGAATGATTTTTCT

TTCAGCATACACCTATTTATTACTTTATTC

TGTTTGTTTGTGTTGAGACAGTGTCTTGC

TCTGTCGCCCAGGCTGGAATGCAGTGGT

GCGATCTCAGCTCACTGCAACCTCCACC

TCCCGTGTTCAAGTGATTCTCCTGCCTCA ^

GCCTCCTGAGTAGCTGGGACTACAGGTA S

CCCGCCACCACATCTGGCTAA I I I I I I GT

A L I I I IAGTAGAAATGGGGTTTTGCCATG

TTGACCAGGCTGATCTTGAACTCCTGAC

CTCAGGTGATCTGCCCACCTCGGCCTCC

CAAAGTGCTGGGATTGCAGGTGTGAGCC

ACTGCACCCGGCCATATTTACTGCATΠT

ATTAAGTCTCCCCTCCTGGTATTCATGGA

AATAGAAAATAACTGTTTTATATTCTGCTG

AAAAATGAAACCCCAATCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6844261 4 99855858 TTTACCACCCTTAAAATTTGCCAAGAAAC C/T ACCTGTGGTACCTATCAGGGTCCGTTTAT SEQ_0209

TTGCCAACCAGAATCTTTATTGTTTCCCC TTTGGACCTGTACTGTATCAA I I I I I GCT CCCTGAAACTCCAAGTCCCCTCATCATTT GTTTATCACATTTGACAAAAGTGTCAGCA GCCTTCTCCCAGCCCAGAGACATCTACC AGTAGAAAGCAGCAATGACGAAGCCCTG TACCTTTCCCTCACAGCATCGCTCCATAA AGGAAAACTGGAACACCCCAGAGAAAGA TTGACCTCCAGTGAAGGACCTACCATTA AAAGAGAAGCAATGTCACATGGCCTTTA CATAAGTGATGTCATTTGCCAACAACTT GGAGCACTGGCTCCAGAGCCTGACTCTT TCAGCCCAAATCCAGTTCTGCTATTCACT GGCTGTGTCAATTGGCTGTGTGAGTGAC TTTACCTCTCTAGAAATGGAGATACCCAT AATACTAATCCTTAGGGTGTTTGTGATAA TGAAAACAGATCAAGGAGGTAAACTGGG TAAAGTCCTCAGCACAGTGCCCGGCACA TGGTAAACACAATAAGTATTAGCTACTTT TTAGAGATCTGTCTACCAATTCAGGAATT AAGAATTCCCTCAGAGATTC

K> K* rs2866016 99861413 TGGGTCAGGACCATGAAGTTAATTTTCTT C/T GAAGTTGGGTTGAGGGGATGAGGGTAG SEQ_0210 O CCTCCTTTTAATCATCAAAATGGAATTTCT GAGGTGAGTGATGTATGGATAAATACAA GTTTTGCCTGTTAGAGATTATTGATATAA CGTTCTATTTTCTAATGGTAAGTATATCT GAAAGGCTGGGCGTTAAATGCTGAGAAC GCCTTCCCTCCCTCCAGTGCTΠTATACG ACATGGACACATAGAGGGGAACAATCAC GTACCAAGGAATATGTTTTGC I I I I I GTC ACCCTGGGGCCTGGTGGAGGGTGGAGG TGACAAAGGGAATTCACAACTCATAACAG GTGGGAGGAGGGAGGGGATTAAGAAAC CTATTTGACATCTTTTGTGGGTACCAAGC AACGAATGGGTACTAGGCTGAATACCTG TCACTTTTCTTCTTTCCAGTGATAAGTGC AGTGATTAAACAGTCTGTACAACAGACCT CTTAATAGAACAAAGTCAACATAATCCTT CCATGACACAAGTTTACCTGTGTAACAAA GCCTCCAGGGAGCTTGCAGTTTAATGAG CCTGCATΠTAAAAGTTAAAAAAATGAAA GGGGGCACATGTTTACAATATAGTGGGG GGCTTTATATCAATAAATAAGTGGGCCTA TCAGTGCTGGGGAGGCATTGAGGAAGAA AAAAAGGGAGACAAAATGAAGGAAAATT CTTAGTGTATGAATCCATCTCCGAACTTC ATTCTGGATTCTTAAGAATAAAAGTGAAA AGTGATGTGGAAMTAAGCTGTTAGAAA ATATCGGACTAAACTGATAAAATGAGGTA GATATCTTGGACTTCA I I I I I CAAGCAGC GAAAATAGAGGAATCACATACACAGTTTT TTGAACTCCTCAAACAATTGTTCTGCAGA GACTTCCAACCCACTTTGCCTTAAGTTAT CTTATTTGCCACGAGATTTGTGACTTGAA TTCAGTTGACAAGT GTCTAGTGTTTAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS1358548 4 99861813 CAACTTCGACTTGTCAACTGAAATAACTT CfT GCCCAGCCTTTCTTATATCAATAATCTCT SEQ_0211

AAGGCAAAGTGGGTTGGAAGTCAAAACT AACAGGCAAAACAGAAATTCCATTTTGAT GTGTATGTGATTCCTCTATTTTCTACCTC GATTAAAAGGAGGAAGAAAATTAACTTCA ATTTTATCAGTTTAGTCCGATAΓΠTCACT TGGTCCTGACCCACGTTCAACTTGATAA TTTATTCTTAAGAATCCAGAATAATTTTCC GAGAGGAGAGAGCACTGTGTGAAGGCA TTCATTTTGTCTCCC I I I I I IAGGCCCAC AGAGCTGGTAAGCTCAGACAACAGAAAG TTATTTATTGATATAAAGCCTTTCA I I I I I ACCGGGACTAACTCCTGCTCATCACTTC TTAACTTTTAAAATGCAGGTTTGTTACAC ACTACACGGCCTTGGCCATGCTGCTGAT AGGTAAACTTGTGTCATGGAGGTCTGTT CTTCACAGCATCAGGTTCCTCATGGGTG GTACAGACTGTTTAATCACTCAGGTATTC ATTTGGGAATAGCAACTGGACCAAGCCT AGCCTAGTACCCATTCGTTGTTTCTTAAT CACAGGGTGAGAAAGAAGAATAAGTGAG CCCCTCCCTCCTCCCACCCTCCACCCTC AGAACGCATGTAAAGTGCCCAGGAGGAG CACCAGGCCCCAGGGTGTGATTGTTCCC ACGTGGCTCCTGCACCTGTGAT CTCTATGTGTCCATGTGTTCTCAGCATTT

AA rs4699353 4 99866311 TATATTTCCTCCTCTAAAGAAGGTAGGCA A/G GCATTTCCCTGAAGGTGTTCACTACACTT SEQ_0212

GGGTTGGGGAAGACAAGCAAGTCTGGAA CTTGCCCTGTCCTTTCACTTTGAGTTCCT K* CAGAAACTCCGCCCATCCATACCCCAGT AAATGAAACCCGTCGTCGGCCATCCTCC K* GAAGCAAGGCACATCGCCATCTCCATAA CGCCCTGCACAGTCTATTCTGCAAACTA ACACCAAGGTGCTGGCCGGGCGCAGTG GATATTCTGTGTCACACTTTTCAGAGTCC GCTCATGCCTGTAATCCCAGCACTTTAG TTTCATTTTCCTGTTTTGTAAAAGTGGTTG GAGGCTGAGGCGGGCAGATCACGAGGT TGTCTCGGAAAGTTAAAACGAATTAAC CAGGAGATTGAGACCATCCTGACCAATA TGGTGAAACCCTGTCTCTACTAAAATACA AAAAAATTAGCTGGGCATGGTGGTGCGT GCCTGTAGTCCCAGCTTCTCAGGAGGCT GGGGCAGGGGAATCGCTTGAACTGAGG AGGCGAAGGCAGCAGTGAGCCAAGATC ATGCCACTGCACTCCAGCCTGGTGACAG AACAAGACTCCGTCTCAAAAACAGCAAC AACAACAACAACAACAAAACAAGGTGCTT GGATCTGGGGCCCCAAAACCTATCCAAG TTTTCAAATAACAGTTGGTCTCTTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1893714 4 99867457 ACAATAACTTGTGTGTGGCCTAGAAGACT A/G TGTGAAGAAAGTTCACCCTAGATTAGTAC SEQ_0213

TCAAATGTTGTTTCTCTAATGTGAATGTT ATGCTGGAAACAAGTGGAAACAAGACCT GAAATAATGTCATTGAGTTTACATTTAATA AGGTTATCCTTAATGCCAGACAGTTGTAT ACATCTTACGTTTGCAGAGTGCTTTGTTT TCTGCCACACTGTGAATTCCAGGATAGC TTTAAGGTGTCTTCATTTATAACATATCAT AAGCACTGGTCAGCAAATTGGCGCAAAC TTTATCCTTTTGATAAAAGGATAGATTAAC ATATATTTGCATTATAATATTTCTTATGGG AACCCTAGAAAGCTGGCTAGAAATTAAG TCAATTAATCTCCTGGAACTAAGAACAAT CTATGATTACTGCATTCTATACATGAGAA CCTGGTCTGGAAGCATGACTGAGACCCA AACTGAGGCCCAGCACAGGTTAAGGGCC GATGTCAGTGCTTAACAG TGGAAAGGGACACACAGCAGAAATGTGA CAGTGTTGGAACCAGACTCCACACTCCT GATCCCTAATCCAGGGCTCCTGCTTCAA CACCTTCCTCTTTGATGCTCTCTAC rs4699354 99867911 TACTGGCCTGACTTAGAGAAGAGGCCGG A/G CTGGATAATTGCTTCTTTTCTCCAACTGC SEQ_0214 AAATACTCCCAGAGTTGTTCACTTAAGGC CTAGACCCACAACCCGGAACTGGCACGC CTGTGATGATGGCCCTAGCAGACAAAGG CAGCTACGCGCAGACTACCAGAATTAGG K* K* AAAGGGAAGGAGGGCAATTACCAGAGAA TTCAAAACAGAAACAGCAACAATGTAATT K* CTTAATTCCCTATAAACACCAATTGGAGT MGCTTTTTACAAACATGATACCATGGCA GACTGATGAGGGCATGAGGGGCACCTTT CAAAATTTTTCATTACCTTGTGTTAATGAA CTTTCCTCCTTAGCAGGATTCTTTACATT AACCATTTTCTCTGACCAACGCGTAAA A rs11943162 99878073 GACCCTCCTGCGTCAGCCTCCTGAGTAG C/G TATGTATCTGTAAATTTGTTCCCTTTTGTT SEQ_0215 GTAAGACTACGTGCACATGCCACCATGC GCTGAGTAGTATTCCATTTTATGGATATA CCAGCAAAAGTCA I I I I I AAACTGGTCTT CCACAATTTGTTTAACCATTCACTAGGTG

TTCAAACTTGGAAAGTCAAATCTAAAGAA ATGGATTCTTGGGTTGTTTCCAG I I I I I G

ACAAGGTCATAATCAGCAGTAAAATTTAC GCCACTGTGAATAATGTTGCTATGAACAT

AAGAAGCACCACAAATGTCTΓTAC I I I I I TCACATACAAGTC I I I I I I GTGGACATGT

AAAAGAAACTTTTTAAAAAAATTCAACTTT TTTAACTTATCTTGGGTAACTACTAAATG

GAGGTATAATTTACATAAAATAAAATATAT GTΠTCCAAAATAATCACACTACAGATAT

TCATΠTGCATTACCATTAAGTGTGTTTTG ATCTTGGAGATATGCAGGTTCCATTCTAG

ACAAATGCATCCAACCATGTAACCATCCC ACCACAGTACTAAGGCAAATATTGCAATA

CACAATCAAAATATACAGCATTCCCACCA AAGCGAGTCACACAA I I I I I I I CTCAGTA

CCCCAAAAAGTTCCCTTGTTAGTACCCCC CACATAAAAGTTATATTTATACTATACTGC

ATGTCAAACTCCAGAAAACCACTGATTTG ATCTAGTAAGTGTGCAATGCCATCATGTC

CTTTCTGTACCTACAGACTAGTTTTGCCT TAAAAAATGTACATACCTTAATTTAAAAAT

GTTCCAGAACTTCATATGAATGAACATTG ACTTTATAGCCAAAAATGCTGAAAATCAT

TATGTGGTCTTCTGAGTTTTATTCCTTTG TTAAGCCTTTAGCACATCGTAATC I I I I I

ACTGCACAA I I I I I CTGGAATTCATGCAT GCTGGTGGGGGGCCTTGCCTCAATGTTG GCTGTT ATGGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs846011 4 99884270 GAGGTGTACATGTGGCTATTTAAAATTCA G/T GTTACCTGAGGTGGGGCTCATGTTGACA SEQ_0216

CCCATTTATAGTTAATGTG I I I I I GATACT CCACCATTTGTTTTCTCTGTCTATGGCAT

ATATCTTAGCTGCCCATCCAGCATTGGTC CTGTATGCACACGGCACATTTCTCCAAAA

AAAAAAATCACGAACCATTGTGAAATAAA GGGACACTGAACACTTGTTTCTGCACAG

CACCTCCCTGTAGCTCCTCTCTGCTGTG CAGTAACAGCTGCTCTGGGCAATCAAGA TGGACTTCACGGAGTTGTCCCCACACAA CCATCTAAAATTATGCACATCACAAGAGC CCCTGCCTCTGGAATCCAGCTTGTCCT CTACATTTTAAATCAGACCACCCTAAACA rs747110 4 153375057 CTGCCCTCAGAAGTGCTGTGGGCAGGCA A/G TGGGTACAGCAAGGTCTGTGGAAGGAGT SEQ_0217

AGGGTACCAGTGCAGACTGACATCATTT GGGCCAGCGTCAAAGCCCCAGCTCTGTA

TTTCAGCAACAAGTGCCCCTCTCCCTGG CTGGCTCAGCCAGGTGAAACTGTTACCG

GGAGTGGGCATGTGGACACTGTCTTCCT AATGGCAGGAGTTCAGTCTAGGTCCCAT

TGTCTCTCATGAAGGAAAGTGAGCCAGG TGCTCACCACAAAGAAAGCCGATCCCTG

CCTTCTTAGGGGGCTTGGTGATCAGAAG AGACAATGAATATTTCCAGGAAAGAAGG

TAATGCCCTCTCCAGTGATCTGCTGCCA C I I I I IATTTGGGGGACTTCAGCCAGAGA

GCCAGACATCACCCAGGAGCACA GACAGGAGCCAAACCTCAAATCTGTCCC

TCCCCTGCTGAATAAAGTTAGGGGTTTAC K.

ATAGCTGGGAAGGAAAACAGGAGGGGC W

TAGGGAGAGGAGTTGGTCCACAGGCAG

CAGGTGCGCCTCATTGTACAAATGTAAG

TTCCTCAAGCTTTGCTTCTACGGGCATCC

AGCTTGTCGGAAAATTGGGTCAGTTTCAT

GACCATGTGCATTCAGCAGGGACCAGTC

AGGGGACAGGAGCCCTACCAGGTATTCT

GGCCAGAAGGATTTTATATAAAGACTTAT

TAGCTAGGTATAAATCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6535836 4 153379897 TGGGCATTTGCACTCCCATGTGACCAGC A/G GAGTCAAGGAGACAGCAGCTGGCAGTTC SEQ_0218

CTTTGGATGCAAGCTGCCTCCAGGAAGT AGCCAATGGGCTACCAGGAAACCAGATG GGGTGTACATGTGGGTGGAGCAGCTTCC GCAGAGAGCCTGGTAGACCACGGTAAG TCTGACAGAGGAAATGACACACCTCTGA GAGTTTGCAGTTTAAGAGTGATGGGAGA CACTTTGCAATGCTTGGAAAGTGTCTCAG TGTTGGAGCACTTTGAACAGGGTGAAAG GTGTGAGTTGGTGGAGCCTGCACTCCCA TCACCATCTGATCTACATTTTAAACGTATT GCAGCTAAGGTGACAAGCG I I I I I CGGT ATTTCACTAAATAGAGAAATAATACGTTTA TCTGCCAGGGGATCTGAGTGGCACACAA AAATGGTAGTAATTGGTCATTGTTATATT CAACATCCACTATGAAATGTGGTGTGTG GTCATTAACAAGTAGAGATTCTAAAGTCT CTGGGTGGGGGCTGACTGAGGAGCTCG AGACTTCTAAAAACAATΠTAAGTGAAGC AGAGTAGGAGTGAGGCAGGCTATTTTAA AAATGTTGCTCCATCTGACAATTATGTAA AGAGGTGGCAAGGGAAGGCCTCTCTGA GCCAGCCATACCTGTTCTTTCCCTGTAG GCAAAGGCAGAGACTTTAGGCAAAGACT GTAGAAGCATATGGGAAACTGCATTCCG TGATTGGTGTGAGGAAGTGAGCCATTCA A AAGTCAAGGGCACCAGAGGTTCTAAGCA GAGGAAACAGCAAATGCAAAGCAGAGAA CAAGCTTGGCACATTTGAGAACCAACAAT K> K* AAGTCCAGTGTGTCTGGAGCCACA rs13147317 153388263 TGGTCCCCAGTGTGAAAACGCCTGAGTA A/G TGAAGGTAATTAGTGAACACCTTCACCTC SEQ_0219 CTTTTGCCTGATTATTATTCCATTTGGTCT TGGAGTCGGGAGGGAGTGCGAGGGGCT AATTGCATTTTAAAATGCTCAGTGGGGAG TTGGTTACTGCAGTAATCTCTTCCTGATT AAAAAATGCCAAGTCTTTTAATAAATTAA GGGAGGAAACTGTTATTTACAAAGGATG GAGCAGGTCTGCI I I I IAACCTGCAGCA CCTGAAGATTCAAATGTGGTTTTCTCTTT GG I I I I IAAAAAGTCCTGCTGAGGGCAC CCCGAATCAGGAGGCAGAGTGTGTGCA ACTGCTTAGAGAGACATGGTCTTTGCAG GGAACTCAAAGCCCATGGAACAGCAGGA

TGC rs6843300 153389654 ACCGTTTCAAGTAAGCCAAAACGTTATGC C/T TCCCCTGTCCCCTGTCCCCACCCCACCC SEQ_0220 CGTGTTTGATGTTTGTAATAAATCCCTTA TGAGCACAACTGGACTCAGAGTCAAAGC CTTTCAGCAGAGAGGCACATGACTTCTA CAGAGCTGGGACAAGTGCAGCTTGTGAA CTAATGGAAAACCAGATTTTCCTCTATCC GGATTCCAGGCCCAGCAAGCGGTTATAT CCACTAAATGAGTGTGGAACCATATTTAA TAAGCACCACTGAGGCTTAAGAAGCATT GGATACACTTTGGAGGGTGCCAAAGCAT AGATAAGATGTGGCTGGTAAGAGTCAAG TGGCTTAATCTGTCAGCTTGATCCTAGG GCCTGGTTACAATTCCTCCTAAGATGTTT

ATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6535839 4 153407519 GCAGAGATGGGTCTGACCTGAGTTCTTG CfT GTCTCTTGAGTTCTGCAGGAGCAATCCA SEQJ3221

GGATCCCAAACATTTTCCCACCCAGAAG CTTCCTTTGGAGGGGTCTGTGGGTCCTC ACAGCACACGGTCTTATGAGCAGTGAAC TCAGGTTTCTTGATTTATTCCTGCAGTCC ATCAGGTCACTTGGGGAACTGGGGGACT TTCTGGAACAAAAAATTCATGATGCGAGC AATTTATTTTCAG I I I I I ACTATAAACATTT CTCCACACACTGCTCTGTCCATCTGAGTT TAGA I I I I I GCTCAGATTGACATTTTATTG GGAGCTGCAATCTAGTCCTGCCTCCCAT GGATATGATTTATATACAGTGAAATTCAC CCGCCATGATTGTAGCAATTCCATAATCA CGTTTCTCTCAGTTTAAACAAATATAGAT GAAAATTTCATTTCAAAGCTTCCAGGGGG GTTCATGTAACTCTCCCTACAATCAAGAT TCCTGGTGTCTTAGCTGTGGATCTCCCA GTAAAACATTTCCATCTTTCCAAAAAGTT ATACCTGCAGGTCGCAGGGCCACAGAG CCCTCGTGCCTCTTCATCATCAAGTTTGA GCTGGGCTTCTAGGAACAGAGGACACAG CCCCCTCAGCCCCATTCCCTGGCAGCCA AGCAGTGAAGACGAGACCTCTCAAAATT CTGATCTGATTTCTGTCTCTATAATTTTGC I I I I I CTAATTCCCTTGTGACTTCCACTTT CTTTTCTAGAATGTTATATAAATAGAATAA GATGACAGGTTATGTACAAGTATATTATT TACAGTATGTAGCCTTTCAAATATGGCTT TAATTTGTAAATATTGTGGGTTTTCCAGA CTTTCACTTAGCATGATTCATTGTGGATA TATCTTTCTGTCGTTGATTTCTAGCTTAAT TATACATGTTGCGCATAGCCATAGCATGT TCTATTAAACCAGAACTCTGGCAGGAGA K* K* TCC I I I I I IATTGCCGAATGGTATTACAA ACATACTTTGCATTACTTCAGTTCATTTAA CGTATGAATGTACCATACTTTATTTATCAT ATTTGCTAAGATTTATTTTATGGCTCAGA TAACTAGTTGAAGGACATTTGGGACATTT ATATGTTATATCTTGTGAATGTTTCATGTG GCA I I I I I GTGATTATGAATAAAGTTGCT CATGTGAAAAGGGAATGTATATTGTGCTA GTAAACATTCAAACACATGTTGCTATGAT TTGTTGGGTAGAGTGCTCTATGAATGTCA CTGAATTTTCATCCCCTCCGAAACTCATG GTTAGCTCAAGTTGGTTGATAGTGTTGTT TTGAAATTTAATTCCCAGTGTGGCAGGAT CAGTCACCTATCTCCTTACTGATTTTCTG TGGGAGGTGGAGACTGTGAGAGGTGATT TCTGCCTGTTCCATCTATTGCTGAGAGAG AAGTCATGAGGGCTCTGCCCTCTGGAAT AATTGTTGAACTCTAGTCACAATTTTGAA GGATTAGTCCATTCATTTATTAATGGATT TTTATCTATTTCTCTTTTCAGTTCTTTCAG AAAGGGTTATCATGGGAGTGAGACTGGT I I I I I GCTTTATGTA I I I I I I I I I I I I I I I I GGCTTTATAAGAAGAGAGAAAGTGACCT TTTGAGACGGAGTCTCGCTCTGTCGCCC GAACTACCACGTTAAGCCCCCTGGCCAT AGGCTGGAGTGCAGTGGCGCGATCTTG GTGATGCCCTGTGTCACCTCGGGACTCT GCTCACTGCAAGCTCCACCTCCCGGGTT ACGGAGAGTCCCCACCGGCAAGAAGGC CACGCCATTCTCCTGCCTCAGCCTCCCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2406625 4 153414178 AGAAAGTGCTTGGTAGTAGATGTATTATG A/C ACATTAGCCTTCATCTGGAGGCCAGAGA SEQ_0222

AGGGAAATCAGTGGGTAATCTTAATTCTG ATTCCAGAGTATTTGCTCTTGTTTTGTGA

ACATTTTGCTAGACTGTGGACTGGGCCA GTGTTCTTTGATGGGGGAGAGGGAAAGG

CCATGTTTCTTATTCACATCTCTATCCCC AAGGATGATCCTTTCCCCTGTGCAATCTC

AGGCCCTAGCATAATACCTGGCACTTAG TCTCTCTCTCTCTCTCTCTCTCTCTCTCT

AAAGGGCTCAATAAGCATTTGTTGAAATG CTCTCTCTCTTTAAACGACACTTGCAGTG

AATTAAAATTGAATTTTAAATTTGGAAGCA GGTGGGCTACTATATTAATCAAATATGCA

TCCTTTCCAAGGGCTGGCTGCCAGTCAC CATATCGTTCTCACTTAGAAGTGTAAGCT

TATTGCAAATTAGTTCTAGTAAATCAAAG AAACACATGGTACACATGGACATAAAGAT

TAAATTAGAAATGCAATAAAAAATAGAGT GAAGAAAATAGACTCTGAGGATTCTAAAC

CTCTAAGTCCAGTGGTTACATGCACTTAC CTGGGAGGAAAAGAGGAAGGTGAGGGT

CTACCACAGCATTTGCCCTTAGATCTGTG TGAAAAATTACCTACTGAGTACAATGTCT

GCTTAGTGGTTTGTTTG I I I I IAAGCTCA AATATTTGGGTGATGGGTACCCTAGAAG

ATGACAGCTTTACCTTTTCTAATAATAATG CCAACCCCCACCATTGTGCATGTAATAC

ATGTGTGCATGTGCCTGTGTCTCTGTGT CTATGTAACAAACAAGCACATGCATACCC

GTCTGTGCATTTCCATCCATGTAAACATG TGAATCTAAAATAAAATTTGAGAAATGAA

TTGACAACAGGTTA I I I I I I AATCACGAA ATATACACATCATATTCTTATTGAATTACT ^,

ATGAAACT GCA ^

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6843947 4 153423076 ATGGAGCATATGTCAGCCTAGAAATCTTG G/T CCGAAGCAACCTCAGAAGCAAAGTCACC SEQ_0223

GAAATGGCAGAAGTGGTCAGATGGAGAT CTAACCTTCTCCTGCCTTTCTGTGTAGGA

GATGCTAATCAAACATTTTCTGAAAAAAA GCTGTCCTTAAAGAAGTTCTCTGACCTAC

AGTTAAATTTCTGAGAG I I I I I CATGTGT TTTGACTGACAGTTGGCCATAAGACTCTC

GGCTTTCAAAAAATATTTCTTAAAATTCAC ATTCCTAAGGGGTCCTGCCCTATACCAG

TATTCATGAAATTCAAGGATTTTAATTTTA GGAAGGAAAAGTGCTACACAGAGAGGCC

TCCTCCCACTATTCAGTAATAGTΠTGTT AAGAAGAATCTGGATAGGCCTTGCTAGG

GCAGTTCTGAAAAATCACGCTCCAAAGTA TTTCCCCCCAAACTCTCTTACCATTAAAT

TGGCACTTTGGCATGCTGAGTACTTTGAA CCTACCTGTATTAATTTGTTTTCATGCTG

CTGAAGGAGGTTGGAAGGCT CTGATAAACACCTACCCAAACTGGGAATA

AAAAGAGGTTTAATTTGACTTACAGTTCC TCATGGCTGGGGAGGCTTCAGAATCATG GCAGCAGGTGAATGACACTTCTTACATG GCAGTGGCAAGAGAAAAATGAGGAGGAA GTGAAAGCAAAAATACCTGATAAACCCAT CAGATCTCATGAGACTTATTCACTATCAT

GAGAATAGCACAGAAAAGGTTGGCCCCC ^,

ATGATTCAATTACCTCCTGCTAGGTCCCT ΪJ

CCCACAACATGTGGGAATTCTGGAAGAT ACAATTGAAGTTGAGATTTGGGTGGGTA GACAGCCAAACCATATCATTCCACCCCT GACTCCTCCAAATCTCATGTTCTCATATT TCAAAACCAATCATGCCTTCCCAAAAGTC CCCCAAAGTCTTAACTCATTTCAGCATTA ACCCAAAAGTCCACAGTCTAAATTCTCAT CTGAGACAAGGCAAGTCCCTTCCGCCTA TGAGCCTGTAAAATCAAAAGCAAGCTAGT TACTTCCTAGTCACAATGGGCATACAGGT ATTGGGTAAATACAGCCATTCCAAATGG

GAGAAATTGACCAAAACAAAGGGATTATA

GGGCTCATGGAAGTCCAAAATCCAGTGG

GGTAGTGAAATΠTAAAGCTCCAAAATGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6823091 4 153427388 CAACCAATTTTTAAACTAGCCACATTGTT A/C AGAGACATTTTGCCCTTTTCCCCCATTGG SEQ_0224

TAATCAAATGATTCATATAAGGAAGCCAA ATATTTCCATGTCTGTGCAGGGTGCTTG ATTCTCACAGACACTGTTAGTAGAGTACC GAACTATGGCAGCCCTCCTGCCACCTTG AGCAGCATTCCTCCTCTCTGTTCTTGCTG ATAAGGGTTAGCACAAAGATCACACCCT GCTGAGCCCAGATCCTGTTCAGGGTCTA GAGGAAGGCTAAACAGAAAACGGGAGG CATCTTCCATTCATGGTTCAGGAAAGGC AACCCAGGTCCTTGAGGATGTTTCTGAG CAATTATGGAAGGCCTTCTTGCCACAACT CCATCAAATTAACCAACCCTGGAATTTCT GGTTTAGACAGGGTTGGGACATGGCAGA TTTTAAGTGAGATAATAAATCCTC I I I Π G GGAGGCCTGCACAGGAGCTTCTTGAAGA CTTAAGCCA I I I I I AGTTGGGTGTCTGTA AATTAATCTTTCCTAGG CTTTGCAACAGCAATAATTCTTATACACT AATGTATAAAACAGATTAAAATTGACAAA TTATTATTAAATATTTATTTTATAGGCTTTA ATTTGTAACTTTTATTATAAGAAGATAATG AAGAATTGCTGAGACACAAAACTTAAAAT GGAGAGTTATGGATATAAATTGAAGTCAT ATCAGTCTTAGCATCCAATTTATTTTAGC ATTTTGTTTTGAGTGTGTAATAGTGAGGG K> K* AAGTCTAAT rs7671283 153433658 TTGCTGGCTCAACAGATCTCTCCATACCT A/G TTCAAAGTTATCTTTTCTGCAACACTTTCT SEQ_0225 TTAGAAAAGAGAGAGAGAAAGGGAGAGA CTAACTCTCCCAGGAAGACTTCACTCTCT GAGAAGAAGGACTGTGCAAGCAGATGGT CCTCTGTGCTACCATAGCTCTTTGTTCAT ACAGTCATCTCTCAAAAGACAAGTTAACC ATCTCATTTACAGCCCTTCAATTTTGTGT TGAAGAATTTCACATCTATTAGAGAAGTG GTGTTAGGATTGCATACATGTTGAAATCT GGAAAATGTGCTCACCTAGGGCAAAGCT CCACTGGGCCAGTCCCAGCCATTGTCTA TAGCTTCCAGACTTCTGTCAAGTGACTGC CCCAGCATCTCTCACAACCCTTCTTCCTT TTCTAATCCTCTTCTTGAAGGCCCA GGCAGCACAACACAACTTGGCTGAGTAT TGGCAGTCAGGTGCGTTGGGGGGCTGG GTCCTTCCTCTCCCAGGCATGTGAGCCC ACTTGCTCTCTCCAGCCATGGTGATTCA GTCACACGTCCAGTGCTTCACAGCATGT GACATGGCCTCATCAATGAGGCAGGAGA GGAAGTGTGCTGGGGCAGAGGCAAGGG GACTTCTAAGAAGTGTTTACTCCTAGCAA AAGACAAAAGGGAAGAGTGTACATATAC AGATGTTGCTATGTGGGAACACGAACAC TCAGAGGTGCTGCAACCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs6848307 4 153439853 CATCTTGTTACTTTCACTACATACCCATG A/G GCAGAGAAGACTTGCTCCTTCCCACATG SEQ

CAGCGTCCTCTCCCCACAACGCGATCCC CTGGCTGTTCCTGGCAGTGGTGACCTGG

ATCTG M i l l GCTGACAGTTAGGTCTCTA CATTGGCTCTTTAGCCCCACAGCAGCAG

AACCAGCACTTACCTAATAGGCTACTGGT TGGGTTCCAGTTTCCAGCTTTTCCCTACC

AGGCTGAGATTTGACGCTCCCCTACCAA CTCCCAGAACCAGCCTTATTATGCCCCT

TCCGAGGGGCAGGAGTGTAGGACCTGG CAGAGGTACTAGCAGCATCCAGGCAGTG

GATGGCCACATCTTGGGCTGGTAGTCCT CCCCTCCCCAGAAGCAGGTTCCCGGGTC

GGGTGCCAACCATTAAGCTACTGCCTCC CCTGGGCTCCATCCTCCAAGCTCCTAAG

CAGCTCCAAACCTACCCTCTGTACTTGG GTACCAGCGGTCCCCGAGCAGCCACCC

GTCTGTGACGCTGGGGCTGGGGGGCTG CTGCTCAGAGAACTGGTCCTAGCTCCCT

CAAATACATTTCTCCTTTTACAGATAACTC AGGTCCCTCTTCCAAGCTCCAAGGTCTG cccAGATGGTCCTCAAGTGAGGCATTGA ATAATCCAAACTTCTAGCCTCTΠTCCCC

AGGGAGACTGGGAGGCAGGAGGC AGCCTAGAGGAGGCAGCTGCAATTCCTC

CATTTGGATTACTTCTGTCTTCTCTACTTT CTCAGTCCTAATGCTTGTTCAACCAATTC CCCATATTCAGCTCGGTCTGTTACTGTAT CTAGAGTGGTTTCTGATGTCCTGAACTG K* K* GACTCTGATTGATGTATCTAGTCATCTCA GTGTGCCGTAAAAACATCATTTTCTATGT GTGTCATGACAGTGAAAAGGCTTGTGAA TCCCCACCCCCTCCATGACAACCTGGGC CCTAGAAAAGCAGCCATTAGATGATATAG CCAGCATTCATTCTCCAGTATACATGCCC AAGAAAATAATTTCAAAATTAGAGTCCAA AGGGTGCTAGCG rs 10023167 153442778 AGTATTAGCCATTAATGTCAACCTGCTCA A/G GGAAATTTTATATCCTTGACTTA I I I I I AA SEQ 0227

AACACTTCAGACTTCATCAACCCCTGCTG ATTGAAATGTTAAATTAACATTTTGTAAGA

TTTTCCTTTGAGGAAAAGCCTAGCAGTGT TGGCATGCAAAATAGTTGGTGTAGTATTT

TATGAATTTATCTATTACCTTTAACTATCC CATAATCCTGTGTTTTAAAGAGAGGAATA

ATAAAATATCATGCAGTTGGGAAAGCCC ATGTATTTTCCCAGGTAAACCAACTAGAA

CAACTTCTCTTTGGTAGAAATGTTCTAAA CCCACTAAAAAATTATCTCAAAATCATAAT

GTGTATATGTATTCTTAGGGGAGAAA GCTAGAAGACCTCTAATGAATCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1986740 4 153443546 GAAGGTTTTAATGACAAAGAAAAATTAAA A/G TGTGTCTCAGCACACAAGCCTGCTCCTG SEQ_0228

GCCATGTATCTCAAAGTGTGGTCTGGGG GTGGTGAAAGCTGCAGAACTGGTTAGGC ATCATTTCGTCATAGCCCCATTATTAAAT ATTAAAGCTGTTCTGGGACCCAACTTGTC CATTATTTAAATACAGATTTATTTAAATAA ACACAAAACAAAGTCCATATGACCAACAG ATAAATATTTATTATTTGGATCATTATTAA TGTGATGCAGGCAAAGTGTGTGGACCAC AATACAGATTCCTGGGTTATGCCCTACAC AAATCAGGAGATTTGGGCTCCAGACCTG CTACTGAATCAGAATTTCTGGCATTTGTA GATATGCCATTATAAAATGCTCAACCTTG I I I I IATCAAATCCCCCCAGTAATCATAA GCCATGACGATGGTTCCCATTTGGGCCT AGGGGATACTAAAGTTGAGGAACCACTG TGATTTCCAAATCTGTAAAATGAAAGAAT GATCTGAATACATGGATATTTTATCCAGG TGAAATACGTTTGTGGTTTTGTTCTGTTTT CAAATAACCCCAAGGTTGTTGGTCCAATA TTGTTTTG I I I I I G I I I I I G I I I I I I CACA TCTGGAAATATGCCTAAGAATTCTGGGCA GCCCTAAGGTCTCAGGAAATTCAAGGGG TTGAAGAGATCTGCTTCATGTACTGATGC GCAATGAGGAGGCTGAATGGGCAGTTCA TG TGCCTACTTCAAGCAGAG rs6535843 153444172 TTAAACAAGCTTTCAGTCTGACAAGAGTT A/G AATGGTTTCCATGGAAAATTAAACAAGCA SEQJD229 TTAGCCACCACCACCACCAGCCCCCAGA ATAAAGACATACAAAAAGGTATTGTGCAT K* TTCAGAGCATTATCCTGCAGATGGTGTCT ATCAGTAACCAGAAAAAGTCTCTTATGGG W

O TATTCTCACAGTGGCATCCTGCTAAATTC ATAGCTCATCTAAATTTGAAAGTACTATC CACAGTGACTGGATAATCATCTCAGGTG AGCTTTGGAAGGTCTTGAGCTCAAATATT GTCACACTGGGAGAAGCAACAGGAACTG AGAGGGGTCAGCCTAAGGAGCTGGGAA ACGTAAGGAACCAAACTTTGTΠTCATGC GCCCAGCAAAGGTTAAGATTTCAGGGCA rs11721471 153446561 ATGTATTCTTTTCCTGATTTTCTCTGTCTC A/G TTCAAGTAAGTCTAAAACCTGCATCAAAC SEQ_0230 TCTCTGTCTCTCTCGCATAGACACACACA CTAACAAGGCATCCAGGTGCCAAAGGTC CTCACACACACTCAACCATATACCTCAGT ACGTTCTACGTCTTGACAGGGTGAGACA ATATTTAGAATACTGACGTCAAAGAGAAA AAGCCAAACAGCAAGTAGTCATTGCACA GATAAAGGGATAGCAGGTCCTAGCTAAC GTAGCATTGCTCATTTGGAGACACTAAAG CCCAGATTCTTACGTGAATTGTCTCCATT GGAGGAAGAGGCACTAACAGCAGTCCA TTTAAAGTGAAATGAAAGATGGAGAA GCAACCTGGTCCAGGGTCTTCCCCCACT GGC rs6849420 153448047 GTTAATCATGCTAAACAGAGTTGGATTTC C/T CTCACAGAGGAAACCAACTTTCTCCCCTA SEQ_0231 TAGCAATACAATGCTCGCATCTAGGGTAT GGATTTGTGGGGAGTAATTTCCCTCAAG CTTTCTGCAAGGTAAGCAATCTTGCCATT CTATTATTACCTTAGGAACCGGTCTCCCA GATTCCCCCAGGCACTTGGTGCATACTG GGGATGAGCTGAATCAAAGCCCAGTCAT TTAGCTGGATTTCAATATCGTTGTGAAAC ACCTACTTTCCCTTCCAAAGGAAGATGCC TCTGTGTCTTTTGGAAATGCTTGTGTAGG CCCTTTAGGTTGCTGAGGCCTGATTCAC TATCCCTGCTTAATGGATGTTGGTTAC ATGTTTATTTACGGGGGAAGGCTCTGTTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2406602 4 153452373 TTTGCC M i l l GTTCCTACCTCTGGGTTC A/G AGTTGGCTATAGCTTGTGATAAATCCTGG SEQ_0232

TGGAGGCCCCCTCCTCACTCTAAATCCC TGGAAGGAGTAGAGCATCTGGAGACATT TGAGCCCTGGCCCCACCTCATTCATAAG GGGAAAGACTGCTGGAAGCCCAGGTTTA GAGGTTGGTGACCAGATGAAGCAGGAG AAI I I I I GCTTGGCTCTCTCTTGACTGGC CACACTTGGAGACCATTTTCATAGTGGG TGTGAAAGTATTGGAAAATCACTTTACTC CAAGCCCTGGACTCTGCAGGTTGCCATT TTTTCTC I I I I I CTTCTCTTCTC I I I I I I GT GCAGTCTCACCCTGTGTGTCCTGGTAGG TTCTTTTCTTTC I I I I I I I I I I I I I I I I I I I I AATATCCATCCACCTTTGCAGGCTTGTCT TTGAGACAATGTCTTACTGTGTCGCCCA CAGGCAGGAGAAGCACCACTATCAACAG GGCTGGAATGCAGTGGCACTATCTCGGT CACCAATGAAGGGAAGGCCAGGAGGGC TCACTGCAACCTCCACCTCCCAGGTTCA AACTTTACAGAGAAGCACC I I I I IAACAT AGTGATCCTCCTGCCTCAGCATCCCAAG TCTTTTGTGAG TAGTTGGAATTAGAGACACACACCACCA

CGCCTGGCTAAI I I I I GTA I I I I IAGTAG

AGACAGGGΓΠTACCATGTTGGCCAGGC

TGGTCCCGAACTCTTGACCTCAAGTGAT

CCACCCGCCTCAGCCTCCCAAAGTGCTA

GGATTATCAGAGTGAGCTACTGTGCCCG K>

GCCCACT rs 16998856 153452674 CAAGTGTGCTCCTGCTTCATCTGGTCAC A/G GTAGGAACAAAAAGGCAAAGGTGGTAAC SEQ_0233 CAACCTCCTTATGAATGAGGTGGGGCCA AGCTGAGATGAACTTCCTTCTCTGCATCC GGGCTCAGGGATTTAGAGTGAGGAGGG CCTGCCATCCTTTCCACCCGCCTAGGCC GGCCTCCAGAACCCAGA ATCTGGAGTTTCCAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs165401 5 143998261 GTAATTGATAATGTGAGCAATTCACTTCT A/C TTTATTTCTACACTTCATGTGACTAGAGG SEQ_0234

CTATTACAAACTTGAACAATAGCCATGTT TTTCAGTCAGCATTATGGTGCAGCAAAGA TCTAGTCTGTCTTACCTTGGACA I I I I l I I GCAGACAGATCTATGCAGACAATCATAT AAACGAATAATAATAAAAGGTAAAATAAA GCACTGAACTGATTTCTTAATAGTTGGAC ATGATTGGATGTTTGTGAAGCAATTCTAA CCAATTGTCCCTCAGTAAGAAAG I I M I I CTTGGGTTAACTATTTTGTTATTCTTGAG AATTAAAATTTAi I I I I IAATΠTGTGAGT AAAGTGTTTGGGGGACCTGGAATTT ACATAGGTATATACATTTATAGGATACAT

GAGATGTΠTGACACAGGCATGCAATTTG

AAATAAGCTCATCGTGGGGAATGGGGTA

TCCATCCACTCAAGCATTTCTCCTTTGAA

TTACAGACAATCCAATTACACTCTATTTAA

AATGTACAATTATTATTGACTAGAGTCAC

CCTATTGTGCTATCAAATAGGTCTTATTC

A I I I I IATAAC I I I I I I I GTACCCATTAAC

TATTCACACCTTCCCCATCCGCCCCCCA

ACAAGCCACTCACTACCCTTCCTAGGCT

CTGGTAACCATCTTTCTACTCTCTATGTC K*

CATGAGTTCTGTTGTΠTGA I I I I IAGATC K*

CCACAAATAAGTGAGAACATGTGATGTTT

GTCTTTCTGTGCCTGACCTGTTTCACTTA

GCATAATGATCTCCAATTTCATCCCTAGT

GTTGTAAATGACTGGATCTCATTCTTTTA

TGGCAGAATAGTACTCTATTGTGTATACA

TACCTCATTTTCTITATCCAGTCATCTGTT

GATGGACACTTCGGTTTCTTCCAAATCTT

AGTTATTGAAAACAGTTCTGCAACAAACA

TAGGTGTGCAGATATCTCTTCAATATACT

GATTTCCTTTCTTTTGAATATATACTCAGC

AGTGGGAATGTTGGATCATATGGTAGCT

CAA I I I I IAA I I I I I CTGAGGAACAACAA

CACTGTTCTCCACAGTTGTTATACTAATT

TATATTCCCACCAATAGTGTTCCCTTTCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs919726 5 144025024 GCAUATACA I I I I I I I I I I CTTGAGATGG A/C GTTAAAGATGATCTCTAATATTAGAAGAA

AGTCTCGCTCTGTCGCCCTGGCTGGAGT TTTTCATTTCCTTTCTTTCTAGTATGAAAA GCAGTGGTATGATCTCAGCTCACTGCAA I I I I I CCTAAAGGGTTTACCTAACTTTGC CCTCCGCCTCCCGGGTTCAAGCGATTCT TGTGCCTTTTGATTCCTATAGTGGATCAT CTTGCCTTAGCCTCCTGAGTAGCTGGGA AGTACAAACTTGGGAGGCAAAATTGTTCA CTACAGACACCTGCCATCATGCCGGGCT TCGGAATGTATAGTATTCCATTTCTCAGC AA I I I I I GTA I I I I I AGTAGAGACAGGGT TGAATAATCTTGGTCAAGTTGCTTAACTT TTTACCATATTGACCAGGCTGATCTTGAA CTCCATACCTTATAAAATAGCAAGAATAA CTCCTGACCTTGTGATCCGCCTGCCTCG TAGTAACTAATCCAGAAGACTGATACTAA GCCTCCCAAAGTGCTAGGATTATAGGTG GATTATGTTAAAATATATAACATTATTGGA GGAGCCACTGTGCCCGGCCTATACATTC ACCAATGATTAGCAAATAGAAAGCGTTCA TTTTAGTTATGGATTTGAATACATCCATAA GTAAATGTAAACTTTTATTA I I I I I CTGAG ACTATATGTTTTGAAAGAATATATGTTTCT TTAACAATTTGGTGTCCTTCTCTGGGCAG GAGACTCTAGTTACATGATCCCAAATTGT TGTTCCTTAAGAGAATCATTGATAAACTG TTTGCAGAAGTGTTATACAAGTTCCATCG TGAAGAATACAGAGGAGAGTGTTCAGGA GCAGCATAAAAAAGTTTGCATTTCTCACC TGACATGAGGTCTAGATGTGCCATGAAC AACTAATTTTGGCTATTA I I M I IAAAAAA AGTAGATAAAAGCTGATGTAGTGTTTTGA K* GATAATGTGAC CTTGGT rs 11744363 5 144040681 CATCAAGCATGCGTGTTATCAGGGTCTG C/T GATATGTGATTTGATTCCATTAGCTGGAG SEQ_0236

TGGAAAGAAAATGTATAAAATGCTTTTAA TTTCCCTGGG I I I I I GATTGGTGCTGTGT CTTGATGAAAAGATGAGAACAGTTCTGGT CTAAAGTCCTGGGGATAAGCATCAAAGA TTTTATTTTGCCCTGAGCTTTCACTGACT CAACTGCTTTA I I I I I ACATGCCAGGGAG TCTCCTTATTAGATTTCTCCCCTGATGTC GAGAAAATCAATCTTCATCCCTTAGGGAC AAAAGTTTGATGTTTTCCTCCTTGTTTATT AGAACTTCTGGTGTCAAAAAGTCCTTCCA TCTCTTCTCAGAGATGACTTTGATAC TCCTTCCAGTACCTTCTTCTTATCACT rs 10065677 144050504 TAATTCAATATTTCTGTAAACCCTATCTAA C/T GGAGAAAATATATTAATGAAATAGGTGTA SEQ_0237 TGAAAATACATAATGTGTCTTGTTAGTAC TGTAAAATTGCGATTCTGATGACTACAAT CCTAATAATTTCATTTATTCATTAATCTTA GAAGAATAGGTACAGCACTATTTGACCTT TAAACACGGGTTAAGTCCTGAGCTAGATT ATGGAATTCTAAAGAGATCAACTATTTCT CTTAATGTGTCAAGACAAACATCATTCTT GTAGGCAAAATTACTCATAAAATGGAGAA TTCCATC I I I I I I CTTTATGTGTAGGGCC TATGTCTGAAATTTATCAAAAATAGTTAAC TGTTGAGCTTTCATGGAGGTAATTTTCAA ATTTATTTATTAATAACTGATTAATTTAAAT TCAATATACAACTATTGAAAACCTACTGT GAGTGGTATCTTCTATCTTTGCATGGCAT GCCAGGAAACATGCCAGGCATTGATGAA TATTTCTCCTCTCTTGCTTTGTCTTAATA ATAATTGTGAGCAAATTCAAAGAGAATTT CTGCCCTCATAAATGTACCATCTAGCAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10051221 5 144059469 TGTAGGCCTAACATTTTAATTACATAGTG A/G TTGGAGTGCCACCCTGGGCTCGATCCTT SEQ_0238

TGCTGGCTACTATAATACTAGACTTATGC AGACCTCTTCTCCTCCTCTTTTACACTCT AGAGAAATTTTTGATACGGGATGTCATCA GTTCCTTAACACCTGTCAGCTCAGTCCTT ACATTGGCAGTATAGTCAACCCTATTATA GACACGTGTTTCAAATCCAATTATTTCTC ATAAAGCTTATTATTATCTCAAATCCTATA ACATCTCCTGCCACATTCCTTGCCTCAGC GGCAAGCAAACATCTTCATATCAA I I I I I CACCAGCTCTCTTGCCTGGACTCTTGCT CAAAAACTCACTTTTCTATTTGTGTTCACA GTAGCTCCTTCACTAATATTTCC I I I I I I C GCAAAGTCCTTTAAAGAGCTTCTTTCTCC TTTATTCCCCTAAGATCCATTCCCCCCAT GTAGCTTCAACCCCTCTTTTCTCCTTCAC AGTCGCTAGAGTGAGCTTCTTAAGGTGC CTATTCCAATAGGACTTTTGTCCTAATAA ACATCAAATTGCAGGTTTTCTCATTAAGA TAAAAGGGCTCTTATTAAGGTTATCAATG TTCTCCAATGCCTTTCCATTGCACATAGA ATCTTTAACTTGTCCTCTTCCTTATCCTTC ATTCAATCCAAACTCCATTTCATGGTGAA CTGTCAACTTCGTTTGACATAGCAGATCC CAAGGGTTATTTTAGATTTGCACATCTTT CTTTCTTCTTAAAGCTCTTTCTTCGCTTG CTCTCTCTTATATTAI I I I I CATGGCTGTC GCTTCCAGGTATCACTCCCTCCTCTCCT GCCTTTGCTTCCTGCATTATTGCCATACT GGCTCCTTCAAGGACTTATCAATTTCCTT GGCCTTATTTGCTCGTCCTCAAATACTAC TGCTGAC I I I I I I CTTAAGTCTTAAGCATT ATGTTTATTTTCAAACCATGCTCTTTTGCA K>

W AAGC CAGCTAG 4-

RS10041987 5 144065147 CTTCTATTGTTCCTTGACACATAATAACC A/G AGAAAATGGTGCAAAAAAAGTACTTAAAA SEQ_0239

AGCATTACA I I I I I CTTTAAAAAATGTGGA ACACAGCCACAACATATCTTTCAAATTGA AGAAACAAACAAGAAAATGTAAAACTTGA TAAAATAATAATAATAATTATCTTAGGGCT AGAAAGAAAAATGTCAAGAGAACCGACA CAACAAACATCAGGTAGACCAAATACAAA GAGAAATAATTTAGCTAATGATGATTACA AGCAATCAAATAATCAACCTATATCTAGA GACAGGGATΠTAACATAACGATGACAAT CACAATATAATGGAAATGCTTAAAACTAA TACATTAATAAATATAGTGGATAAAGTAG GTATAAAAAACAATATATATTTTTAAAGCC ACAAAATCTGCAAACAAATCAATAATTTTA ATTTAAGGAAGAAACATTACATATGGGAG CAAGAGTTATATGCTCTAAAAAAGATGCC GACAGTGATAAGAATTATGGCTGACTΠT AAATTAAAATGACAAAATAAATACTTGATA CATCAGTAAAATAAAGGTCTGAGGTTAAT GGAAAAATGAAGAATTAATCTGATAATCT GGAATGATATTTTAAAAGGATAAAAAACA TGACAGATGATGGGACATAGTAGAAAAA AATAGACATGTCTATCTAAAAAAAGATAA ATGTCAGTAAGCTTAAAGAAAAAAAATCA ATAAAACTGAGATAATTCATCTCCAATAG GTAAGCTTAAAGCTAAACAGAAGCACAAA TCCTGTATTACATAAAATGCTGAAATAAA GAGAAAAAATATGTGAACAAAAAAAGAAT ATTCATTAGGCTGAAGGGTTGATACTAAA GATGCCAGGGAGGCAACACCAGCCAACT TAGAATCTTGGATCTGCAAGAAGGAATAA AACATACATATAATAGAATACTATCAAGA GAAATACTAATGAGGAAAAATTTAGAAGT

GAGGAGA AACTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7704793 5 144065554 AAAAAAAAATTGAATCCAGTGGGGAACTC AJT AATTCATTAGGCTGAAGGGTTGATACTAA SEQ_0240

AATCTTAGTAAACTACAATAAAAACCAGA ATAGAATCTTGGATCTGCAAGAAGGAATA CACAGATAAATCACAAGTTAGCAACCTG AGAAATACTAATGAGGAAAAATTTAGAAG GTAAAAGAAAGAGCATGTCCTTCTTTTCT TAACTAAATTAAi I I I ICTCTAATTTTAGT GAATGTAATATTATTTACTTCACTTCTATT ATACTAGTTTAAAACATTTATTCCAATTAT GTTCCTTGACACATAATAACCAGCATTAC TATTGACTAATTCAAACAAAATTTATAAAA ATTTTTCTTTAAAAAATGTGGAAGAAACA GTATACCATAGAAATTTTAGTGTACGTAA AACAAGAAAATGTAAAACTTGAAGAAAGA AAGTAAAATGTATGACAACAGAGCTTAAA AAAATGTCAAGAGAACCGACAGAGAAAT GGGTAGGAGGTAGATAAATAGAACTATT AATTTAGCTAATGATGATTACAGACAGGG ACATATTGTTATAAGATTCATACAATTTTC ATTTTAACATAACGATGACAATTACATTAA ATTAAGTAGAAAAATGTCATATGAATATA TAAATATAGTGGATAAAGTAGACAAAATC GACTGATATAAATTAAAGATGCATATTAT TGCAAACAAATCAATAATTTTACAAGAGT CATCTCTAGAGTAACTGCTAAAAATATGT TATATGCTCTAAAAAAGATGCCAAATTAA AGTGAAAAACCAATAAAAATATGAGTTTT AATGACAAAATAAATACTTGATAGGAAAA TATAAAAAATACACAATTCACACAAAAGA ATGAAGAATTAATCTGATAATCTTGACAG AGGTAAAGAAAGAAGAAACAGAGAGTTG ATGATGGGACATAGTAGAAAAAATGTCA GGAAAATAGAAAAGAAGTTCCAAAGTTCT 1»

W GTAAGCTTAAAGAAAAAAAATCAGTAAGC CTGCTTAAGCCCAGCCACATCAAACTTAT Ul TTAAAGCTAAACAGAAGCACAAAGAGAAA ACTAATTATAAATGATCTAAATTTCCTGTT AAATATGTGAACAAAAAAAGAATGATGCC GAAGTGGTTGTTACCAACATGTGCAACA AGGGAGGCAACACCAGCCAACTAACATA GATCTTCAGTTCATAACAATATATTGTGT CATATAATAGAATACTATCAAGAGAGGAG ACTTGAAAATTGCTAAGAGATTTTGCATT AGAGAAAATGGTGCAAAAAAAGTACTTAA CTAATCACACAAAAATGATAAATATACAA AAACACAGCCACAACATATCTTTCAAATT TGTAATGCACATGTTAATTTGCTTGATGT GATAAAATAATAATAATAATTATCTTAGGG AGCCATTTAGGC I I I I I I ATCAATTAAAAA CTCAACAAACATCAGGTAGACCAAATACA AAGAATGCAACTTTAAGCAAAATAAAATA AAAGCAATCAAATAATCAACCTATATCTA CAGAGGTTAAGAATAGGTGAGAAAGTAA GACACAATATAATGGAAATGCTTAAAACT GACCAAGCTATATGCTTTTGAAAGGAGC AAGTATAAAAAACAATATATATTiTTAAAG ATATATTTTATATAAAGACACAGAGAGTTT CCATTTAAGGAAGAAACATTACATATGGG GAATGGAAAAGAGTGGGAAAAGAGGCCA AGGACAGTGATAAGAATTATGGCTGACTT AACAAACATTAATCACAAGAAATGTGGTC TTCATCAGTAAAATAAAGGTCTGAGGTTA TGGCTATTCTAATGTATAATTTAAAAAAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS11951969 5 144072265 AGCTGGCCTAAATAGAGAAAACCTTGTG C/T TAATCCTGTATTTATGTTATCTGGTCAGT SEQ_0241

GGCTTTGAGTTGGGGTCAGAAAAAAACA GGTAGGCTACTAGTAGTTATG I I I I I GAG GAAGCAGGAAGAAACTCCAAGACAGAAT GAGTGAGAAATTGCTGTATTTTCAACTCT GAGCACATTGGCCAAGGCCTGGGAGCA GTGAGGGGGCTCATTAGGTTTGCTGAAC GGATTGAGGAGGTAGCGAGGAGAATCTG CCCTGTGCTGTTGAAAGGTCAACTATATA TAGTAGAATΠTGCTTATTA I I I I I GCTTA TTAAATTGGAGATTTAAAATGTCTGTATTT ATACTATACATATTAAATATCTATATGTGT TAATTGTGAATGAATCTACATGCCATGTA ACAGTTGACCCTTGAACAACACAGGTTT TCCAAGTTATTCAAAATTCCCAAGGCTAA GAAATGCACGGTTCCACTTTTGAGCAGC CATTTGTTCACTCATTCAtTCAACAAAATC TTTTCTTCTACCTCTGCCACCCTTGGGAA ATCTATTTTGGTCAGTGTGTTAAAATAAG CACAGCAAGACCACAACTTCCTCTTCCTC TGATACAAAAAAAAAAGATTGAATCAAAT CTCCTCCTCCGCCTACTCTATGTCAAGAT TTTGTAATAGGTCAACCTA GACAAGGATGAAGATCTTCATAATCTACT TTCACTTAATAAATAGTAAATATATTTTCT CTTCTTTATGATTTTCTTAATAGCATTTTC TTTTCACTGGTTTCCTTTTCTGTCAAGAAT CCAGTATATAATACATATAATATAAAAAGT K*

ATGTG rs 10476862 5 144072386 GGCCTGGGAGCAGGATTGAGGAGGTAG GFT GCTGTTGAAAGGTCAACTATATATTAAAT SEQ_0242

CGAGGAGAATCTGTAGTAGAATTTTGCTT TGGAGATTTAAAATGTCTGTATTTTAATTG ATTA I I I I I GCTTAATACTATACATATTAA TGAATGAATCTACATGCCATGTATCCAAG ATATCTATATGTGTACAGTTGACCCTTGA TTATTCAAAATTCCCAAGGCTAACATTTG ACAACACAGGTTTGAAATGCACGGTTCC TTCACTCATTCATTCAACAAAATCATCTAT ACTTTTGAGCAGCTTTTCTTCTACCTCTG TTTGGTCAGTGTGTTAAAATAAGTGATAC CCACCCTTGGGAACACAGCAAGACCACA AAAAAAAAAAGATTGAATCAAATT ACTTCCTCTTCCTCCTCCTCCTCCGCCTA CTCTATGTCAAGATGACAAGGATGAAGAT CTTCATAATCTACTTTCACTTAATAAATAG TAAATATATTTTCTCTTCTTTATGATTTTCT TAATAGCATTTTCTTTTCACTGGTTTCCTT TTCTGTCAAGAATCCAGTATATAATACAT ATAATATAAAAAGTATGTGCTAATCCTGT ATTTATGTTATCTGGTCAGTGGTAGGCTA CTAGTAGTTATG I I I I I GAGGAGTGAGAA ATTGCTGTATTTTCAACTCTGTGAGGGGG CTCATTAGGTTTGCTGAACCCCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs2190593 5 144081220 TGTTTTCTTAGCCTACAAGATCTCCAGTA A/T TATTAACTATGAATGACTATTAATTATACT

CCAGCTCTTCCCATTGTAGTGCATACCTT CCAGGAGTGAATACTTAATGTTTAAATAT CCCATCTACAACTCTTTATAAGGACTGAA TATATCCAGAGAGTCTATGACCATTTGTG AATATGGAAAGCAAGATGTATTTTAAGTG ATTCTGAAGACATAAAAAACTGGTTCAAT GAAAATTCAAATGTGAACTAAGGGCTAGA AATGCAATGTTACTTCTGAGGTTCAACAA AGAAGACATGTATTGGGTAAGGGATGAG GATAGTTAATTTTAAATAGGTCAAATATCA GGATCAGATCAGTTACGGGAGGAACTGA GTGAGAAAATACACAACATGTACTGAGTA GTTGACTGGCATCATTACAGTGAAGGAT TAAAAGTGCTTAATAAGTGAGTCCTGGCA GATAAGAATATGGCACAAAGTAGGGAAT CTTAATAATACAATTTGT TTTCTAT

RS6873082 5 144081714 AGACTGGCATAATGCCACTATTTCTTGTA A/G TCTCTTTGAGGGAATTTGAGGTAAGCTCT SEQ_0244

AATTAGGATCAACCCTAAATGGAAATGCT GAAGTTTTATATAGATATTCTCATGGCGC AAATGAAATCTTTTAATATGTTCAGCTCA TATATAAATTATTAAATATATGTA I I I I I I I GTGGGCTTCAAAAATATΠTACTTCAAAG CACAATAGAGATGTGATACTTTCTACTTT CTATTCATGAAGTTTTGGAATTTTGAACA CTGGATATTCTATTAGAAGATATACAGCA I I I I I GTTCAAAGCCCCAGTGCTGTGAAA GCAGGTTTAGAGCTGTGCACATGATTAG TTCGTGTGCAGATCCAAGAAAAAAGA CTCTCAACAAATGCTATTCACTCACTGAT K*

GAAGTGTAGGCTACAACCATATGCTTT rs 10068035 144081903 CCCCAGTGCTGTGAAATTCGTGTGCAGA C/T TATTCACTCACTGATGAAGTGTAGGCTAC SEQ 0245 TCCAAGAAAAAAGAGTCTCTTTGAGGGA AACCATATGCTTTAAGTGAAGTTGATTGA ATTTGAGGTAAGCTCTGAAGTTTTATATA GCCTGTATAATATATCTGGCCATGGTTGA GATATTCTCATGGCGCTATATAAATTATT CCCACAGCACTAGTTTCCCTGCATGATG AAATATATGTA I M i l l I CACAATAGAGAT GTTCTTGGCAGCAAACAAGGCTGATTATT GTGATACTTTCTACTTTCTGGATATTCTAT TTACAGCTTGGTGCCCTGTTTTCCCAATG TAGAAGATATACAGCAGCAGGTTTAGAG CCTTTGAATCTTGCCACAATCACACTT CTGTGCACATGATTAGCTCTCAACAAATG rs 10068047 144081936 GAAAAAAGAGTCTCTTTGAGGGAATTTGA C/T ATATGCTTTAAGTGAAGTTGATTGAGCCT SEQ_0246 GGTAAGCTCTGAAGTTTTATATAGATATT GTATAATATATCTGGCCATGGTTGACCCA CTCATGGCGCTATATAAATTATTAAATATA CAGCACTAGTTTCCCTGCATGATGGTTCT TGTAI I I I I I I CACAATAGAGATGTGATA TGGCAGCAAACAAGGCTGATTATTTTACA CTTTCTACTTTCTGGATATTCTATTAGAAG GCTTGGTGCCCTGTTTTCCCAATGCCTTT ATATACAGCAGCAGGTTTAGAGCTGTGC GAATCTTGCCACAATCACACTΠTCTTCA ACATGATTAGCTCTCAACAAATGCTATTC TGTTATAGGTAAGAAAAATGAGTTAT ACTCACTGATGAAGTGTAGGCTACAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs10068108 5 144081963 GAGGTAAGCTCTGAAGTTTTATATAGATA C/G CTGTATAATATATCTGGCCATGGTTGACC SEQ_

TTCTCATGGCGCTATATAAATTATTAAATA CACAGCACTAGTTTCCCTGCATGATGGTT TATGTA I I I I I I I CACAATAGAGATGTGAT CTTGGCAGCAAACAAGGCTGATTATTTTA ACTTTCTACTTTCTGGATATTCTATTAGAA CAGCTTGGTGCCCTGTTTTCCCAATGCC GATATACAGCAGCAGGTTTAGAGCTGTG TTTGAATCTTGCCACAATCACACTTTTCTT CACATGATTAGCTCTCAACAAATGCTATT CATGTTATAGGTAAGAAAAATGAGTTATC CACTCACTGATGAAGTGTAGGCTACAAC ACAAGTCTATTTGAGAACATTCTGGG CATATGCTTTAAGTGAAGTTGATTGAG rs2041070 144083568 AGGTACTCAATAAATGATAATTTTATGAC CfT TGTAGCTTCAATGAACAGATTGATGCCCA SEQ_0248 ATATCAAGTGATTTTAACAAAATCTCAGT ATGTGATAGGCCTCCCATTAATTAAAAGA AGATAATGCTAGTACATTAGTGACCATCT CTGATGTTCAAGGAGATAAGGACAAGGG AATGTAGAGAGGTCATGTTAAGTTAACAG TTGTGCACATGTTATTCCTTGGGAAAATG GTGCATAGCCTTTAGTTCAGATGTCAACA GTGAGAAGAGAGGGAAATGGGGAGAATT ACCTATGGCCAGGAGAGAGAGGATCTTA GAGGGCAGAAATTACAGAAGTAAAGTAA TGATTCAAAGCATATAGATTTATGTATAG ATAATACTTGTGAAGAATATTGGTTATCT GAACTCCCCTGGGGCTTTGTTGGTCAGG CTTGGTTTCAAAAC I I I I I AGCTTGCTAT K* AGCTATAAATCAATACAGGCTCTCAGAGC GTGTGTTTCTGTAACATTTCCT ATGTTTATTTCACATGTTTAACACTGAATT GCCATATTAAAAACAGAGTTTCCTGATAA TCACTGTCCTAAAGGTGAACAAAGTTTGG CAGGTTACTTATAATATCCCTTCTGACTG AGAAGCCCTGACATCATTTAACTCTTGGA TGACCTTCC rs1 1953855 144095707 TTGAGGTTTGTTCGTTTAATCCTAGTTTC A/C ATTTTGGAATTTGATATTGGTCTGTTCAG SEQ_0249 TTTAGGG I I I I I ATCATGAAGAAATGTTG TGTTTCAATTTCTTCCTAATTTAATTTCGG GATTTTATCAAAAGCTG I I I I I ACATATAT GAGATTTTGTGTTTCCAGGAATTTATGTA TGAGATGATCATATGGTTTCTGGTTTTAA TTTCCTCTAGATTTTCTAGATTGTGTCTGT I I I I I I ATATGATAAATCACATTTATTGAT AGAGGTGTTCACAATAGTGTCTGAGGAT TTGCATATGTTGATCCAATCTTGCATCCC CTΠTGTATTTCTGTGAGATCAGTTATAAT AGGAATGAAACTTACTTGATCATAGTACA CTCACA I I I I I CTTTTCTGAGTGTGCTTAT TTAAC I I I I I GATGTGCTGTTGAATTCAG TTGTATCTTCTTTC I I I I I I CTTTGTTAGT TTTGCTAGTAATATGTTGAGGA I I I I I GC CTAGCTAGTTGTCTATCCTGTTGATCCTT ATCTATGTTCATCAGAGATGTTAGCCTGT TCAAAAAACTAAC I I I I I ATTTCATTGATT AATTTGC I I I I I I CACATTG I I I I¹TGCCAG CTTCGTAGAGA I I I I I I ATTTTAGTTATTT GTTTTGGCATGAGAGTGATGTTGACTTTG A I I I I I I I CTGCTGGCTTTGGGTTTAGTTT TTGAATGAGTTGAGAAGGGGTCTCTTCT GTTCTTG I I I I I CTAGTTACTCTAGGTAAT CCTTGATTTTAAAAATAGTTTCAGAATCAT TAGAGTAATATCTGTTAGATCATTGATTT TGGTACCAACTCTCTGTATGTTCAGTAGC GAAATCTTTC I I I I I GAGGTAGGCATTTA ATTTGGTTGTGAATTCATCTGGACTGAGG GAACTATAAACTTTCCTTTTAACACTGTTC C I I I I I I GGTTGGTAGGTTTTAACTACTG TGCTGCATCCCAGAGATTTTCGTATGT ATTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS13154970 5 144096815 TGTGCTTCTGAGAGATCGTGGTATTGATT A/G ATAGAATCATGACCCCTGC I I I I I GTCTT SEQ_0250

TTTA I I I I IATTGCACTGTGGTTTCAGAGT TTGTTCACGTGGTAGATCTTTCTTCAACC ATGGTTGGTATGATTTTGA I M I L IAAAAA ATCTGCTTTGAACCTATAGGTGTCATTAA ATTTATTGAAGCATGCTTCATGCCTGAGT ATGTGAGATAGTTTTCTTGAAGACGGTAG ATGTTGTCAATATTGGAATATCTTCCATG ACAGATGGATTCTTTAAAGAAATCCAATT TGCAGATGAGAAGAATATATATTCTGTGG TGCTACTCTGTGCCTTTTAAGTGGGGTTT TTGAGGAGTAGAATATTCTGTAGATATCC TTAGACTATTTATATTTGATGTTAATATTT ATTAGGTCCAGTTGATCAACTGTCAAATT ATATGTGAAGTTTTGATCCTATCAAGACA TAAATCCAGAATTTCCTTGTTACTΠTCTG TTGTCACCTGGTTGCATTCTGTTGTGTTT TCTTGACCACCCATATAATGCTGTCAGTG TGCTTCATAGGGTCTGTGGGCTATGTAC GGGTGCTGAAGTTTCACATTGCTAΓΠTG CTAAAATGTTGTTC I I I I I I I I I I I I C I I I I TGGCTTTCCTTTTGTGGGCCTTGAAGTAC TGTGGTAACAGATAATACTCTTATGTTTC TTGTTTTATGAATCTAGGTGCTCTAACGT CAGATGTGTGTATAAGCATGGAACTGGG TGGGCATATATATACTTAGGACAGTTAAG AAACCTCCCGAGCTTCAAGTTCTCTGCAT TATTCTTACTGAATTGAGTGTTTTATCATT GGTGATGAGGAGTGCCTTAAGTTCCTAA ATATAATGCTATTCTTTGTCCTΠTGAAAC TTCAAGAGAATAGGTGCTCTGGATGCCT TGCTGTTGGTTTAAAGTCTATTTTATTTGA GGAGATTTGCCTGGGCATGGAGCAGAGA K*

T GGGACCCCC rs 10053832 5 144100185 GACAGAAAGGGGAACAACACACACCGG C/T CTTACTCCATCTCATGGGTCTACCTTTCT SEQ_0251

GGCTAATCAGGGGGTAAGGGGGAAAAG GTTGA I I I I I I CATATGGTTCATTATTAAT GGAGGGAGAGCATTAGGACAAATACCTA GATGACCCTAGGTGGAATAAACCTTACAT ATGGATGTGGGGCTTAAAACCTAGATGA TΠTATAATTCTGAGTTGAATCAATAAACA CAGGTTGATAGGTGCAGCAAACCACCAT GAGATCTCTTCCAACAGTTCAAACTAGAA GGCACACATATACCTATGTACCAAACCAC GTTGGTTATATΠTCAAACTAACTGCCAA GTTCTGCATTTGTATCCCGGAACTTAAAG AGCCTAAGGATTCAAGGTTATGATTTTCC TCAAATGTTTTTTTAAAAAGAAAGTAAATG AGGCATTGGTCACATGGAGCATCTAGTT AACAAAAGCAATAAAAATAAACTTCTAAG AGGGGTCATGTTAGCTCACCCAAATCCC TTAGAATTCTATACCTATTATAATATTCTT CTGGAAGTGGTGGTTCCCCAAAAGAAAT CAAAATGAGGGTTAAAGACATTCTAGAAA TGGAGTTATATTATTTACAACATGGGGAA ACAATAATTTCAGAAATCCAGCACTGGCA AGGTGGAAAAGCAAAGAGAGTAAGTGAC GATCCAGATGCACAAAGGAAGTGATTAG CATTTTCTTTACCTGTGGCACATTT GACTTGATCTTTACTATTATTATTATTATT ATACTTTTAGTTCTAGCATACATGTGCAC AATGTGCAGGTTTGTTACATATGTATACA TGTGCCGTGTTGGTTTGCTGCACCCATT AACTCATCATTGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7730888 5 144102464 TTGACTGTGTTGCTCAATΠTCTTCTCCA A/G ACTTTTACTAGTATTCTAGGCCAGTAGTT SEQ 0252

TTAGGTTTGTGAGGGAGAAAAAGACTGA AACAAACTAAACCAGACAATAAATACTTC AGTAAAATTCTCAAGTTGAAGCCTTACTG AGGCTGTGAGGGCCTTATTAGGTCTCTG CCATTAACTGACAAAGAGCCAGGAAAGA TTGCATATTCTTGC I I I I I I GTTG I I I I I A AAAGCCATGTTGCCATGGTAGTATAGAAT CAACCTTTTAAAATATAAAAATTGATTTTA GTTGGTATCAGTTAAGACTCTTGACTACG GCTCATAAGTCATACAAAAACAGGCCAT AGTGTCAGAGCCCTAACTCAAGTGGCTT GGGATTTGGCCTACACAACATAGATTGC AAAAAAGCAAGGGAGATGTGTGGGCTCA CAACTCCTGGTAAAATAAAATCCATATTC TATAAATGCAAAGACAAAGATTTTCTTGC AAAAI I I I I GTTAATTCTTCCAATAACATT TGGATCTAAAGCTGAAACAAAATACACTT TTTATTACCA I I I I I CCAGGCATAGGACT CATTCATAATAACTTATTGTATTTAGTTAT CATGAATCTTTAGTCTGTTTTAAAACACAT ATTAGAG I I I I I I CC I I 1 1 I I I I CCCCCTG CAAGACGGTAGATTAGAGGCTTTTAGCA TGCCTTAGCCATGTGAAAATAGCAAGATA GTCCATAAGGACATCCCACATTCAGGAG AGAATGCCAGCACAGAATCCCCATGGTG K* ACTGCCTGAGAAAAGTAGATGAAGCCTC O TGTATGTGAGAGAGGCAGAAAGCCTCCC TCTGTGTATCACATTTCCAGTAGGGGTCT GAGAAACTCAGGCCATGGGAGAGCCTTA GTTTCTCCCTAGACCTGTAGCTAATCTGA GGAAAGTTTTGGAGACACTGTGAGGAAA AGACACCAGAAAAAGATGCAGACATTTTA TC I I I I I I I T IT I CCT IT I T I T I T I T I T I T IT I T ! T I T I I I G AGACGGAGTCTCGCTCTGTCGCCCAGTC CGGACTGCGGACTGCAGTGGCGCAATCT CGGCTCACTGCAAGCTCCGCTTCCCGGG TTCACGCCATTCTCCTGCCTCAGCCTCC CGAGTAGCTGGGACTACAGGCGCCCGC CACCGCGCCCGGCTAA I I I I I I GTATTTT TAGTAGAGACGGGGTTTCACCTTGTTAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3853465 5 144109009 ATATGTAATAATTATTCAGGGATTTGGTA CfT TTTAAAATGGGGAGATTATCTTGCATTAA SEQJ3253

TAAATGTCCATCATCCTTTCAATCATTCAT CCTGAATCTGAGTCTTTAAAGACTGAGAA

TTAGTCATTGTTTATTGCATATGCTGGCC TCTTTCTTGGCTGCAGTCAGAGGTAGATA

TAG I I I TTAGGCACTCAGAATCAATGTAA TAACTATAAAATAAAGGATCAGAGAGATG

GCTTTGGTTTTGTTAGGATAATAAAGATA CAGCATTGTTGGCTTTTAATACAGAGAAA

ATAAATGAATAAAGAAACAAACAAATATG AGGGTCTGGGAGCCAAGGTTTGTGGATG

ATAACTTAAGATAATCTTAAGTACATATGA GCTTTGAAGAACTAGTCAAGACAGAAAAA

TAAGCAGAATAATGGCTCTAAAAGATATC TGGCTTATTACCCAAAGCCTCTAGAAAGA

CACATTCTAATGTGTAGGATCCGTAGATA AATGAAGGCTTGCTAACATCTTAATCTTA

TGTTACTTTACATGACAAAGGGGACTTTG ACCATAGTAAGACACTTGGACTTTTGAAC

CAGATGTCACTAAGGTTTAGAA TACAGAATTGTAAGATAATCCAGTTGTAT

TGTCTTAATCTACTAGGTATGTGGCAATT

TGTTACAGCACCAACAGAAAACTAATAAA

ATATTATAAAGAGCATAATATAGGATAGT

GACATAGAAAATGGTGGTGTTGGTGAGA

TGTCAGCACTAGCTAGGGTGATGATAGA

AAACTTCCCAACAAGGAAACATGACAAGT K.

AAGTCAGGAG £

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS3853466 5 144115729 TAAGTCTCTCTG I I I I I AGAATATCTGTA C/T AGTCCAAGTGCACCCTTAAGTATGCAGA SEQ_0254

GCATTTAATGTTCGTAGGTCTCATCCACA CATGCTCTGCCACAAGCAGAATTCCAGC CTTATCTATTGCCTTTAGTTATTAGCTCTC TGTGTACAGACCTTTGGTCTTTGCTAAGT TCTTATGTACCTATGTTTTGCCTCTTGAA TTACAGTCAAGATGTCCCAGAAGAATAG CTAGTCTACATGTTCTTCATAGATAGGTC GCAGGACTGACTGAGATTTACTCAGCTG TTGTACAATGTCTAAAATGAAAATGGTAT TTTACAGATTTTCAACATTTTGCATCCTGT AAATAATAATAATATATAATAGTACGGAAT TCACAGTTCACCTCTTGGTTTAATTCACA AAAAATGACCACTTACTGAGGACCGTTCA TCCAATTAGTCTCTG I I I I I G I I I I I I GTT ATTCTAGGCATTGTCCTATGGACATATGT G I I I I IAAAGATTTTAGTCTCCATCATTTA TAACTTATΠTATGCTCATAATAATTCCAT ACCAGTCATTGACTTGCACACCCCCATG GAGGTTGGTATGATTGACCCCATTTTACA GCTATGCTTATCGTGTTCCTTCATCTTAG GATGAGGAAACAGAAGCCTAGGGAAATT AAACCCTCCTCCCCTTCCCTTGTCCACAT AAATAACTCTCTCTGGGTCATAGATCCAG TAAAATTGTTTACTGAAGCTTCTAACCCA TAAGTTATTGAAGCAGAATCCTCTATAAC GCTCAAATGTTATATTTTCTCTGTAACTCT ACTCATCACAGAGCTCTCTATATTAGCAA CCTGGACCTTTCTACCTTGAATCCTTATC GCACTCAACAAAGAATGGTAAATGCCAT TCTGCATCTAAGTTATATGTAGCCTTTGT GTTTGTTAGGCATCTTCTGTCTCAGGCTA CATAATGCATTATAATTATTTCCCTAGGT K*

4- CTGGAAAGGAATTTTGTTTGAAATTTCTA GCGTGTGTCCTCCACTAGACTGTCAGCT K* GACCCCCTACAACATGGCCTAAACAAGT CTTTGAGGGCAGAGTACAGCGTCACTTC ACAGTGCTAGCTGCCCA ACATTCCATGCCTCATACATAGTGGCTTA ATACTTACTAAATGTGGGTTAATGTGAAT GGAAATGTGAATGGGACTAGGGAGATAC AAAGACCATGGTAGAGTTAAGCTAGCCA TGCTTTAGGCCAGTAATTGTCCTCTGTCT GATATGATTCTCTATTTCTAGCAATGAATT TAAAAAATGAAATAATTCTGAGTTAGGAG ACTCTGAAGGGAAACATTCTAGTTTTCAC AGTTTATCTTTTTATGTAGGATGAGTCTT GATCTGAATTTATAAAATATCAGGCAAAC TCTTGTTAAAATCTCTGTTATCAAAACTTA TACCAATGCCAAGATTATTCTTGAAAAAT ATTCAATATTAAATTAACCATTCCCTTCCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1010349 5 144116210 TAAGTCTCTCTG I I I I I AGAATATCTGTA C/G TCTTATGTACCTATGTTTTGCCTCTTGAA SEQ_0255

GCATTTAATGTTCGTAGGTCTCATCCACA CTAGTCTACATGTTCTTCATAGATAGGTC

CTTATCTATTGCCTTTAGTTATTAGCTCT TTGTACAATGTCTAAAATGAAAATGGTAT

AAATAATAATAATATATAATAGTACGGAAT

AAAAATGACCACTTACTGAGGACCGTTCA

ATTCTAGGCATTGTCCTATGGACATATGT

TAACTTATΠTATGCTCATAATAATTCCAT

GAGGTTGGTATGATTGACCCCATTTTACA

GATGAGGAAACAGAAGCCTAGGGAAATT

AAATAACTCTCTCTGGGTCATAGATCCAG

TAAGTTATTGAAGCAGAATCCTCTATAAC

ACTCATCACAGAGCTCTCTATATTAGCAA

GCACTCAACAAAGAATGGTAAATGCCAT

GTTTGTTAGGCATCTTCTGTCTCAGGCTA

CTGGAAAGGAATTTTGTTTGAAATTTCTA

GACCCCCTACAACATGGCCTAAACAAGT

ACAGTGCTAGCTGCCCACAGTCCAAGTG £

CACCCTTAAGTATGCAGACATGCTCTGC W

CACAAGCAGAATTCCAGCTGTGTACAGA

CCTTTGGTCTTTGCTAAGTTTACAGTCAA

GATGTCCCAGAAGAATAGGCAGGACTGA

CTGAGATTTACTCAGCTGTTTACAGATTT

TCAACATTTTGCATCCTGTTCACAGTTCA

CCTCTTGGTTTAATTCACATCCAATTAGT

CTCTG I I I I I G I I I I I I GTTG I I I I IAAAG

ATTTTAGTCTCCATCATTTAACCAGTCATT

GACTTGCACACCCCCATGGCTATGCTTA

TCGTGTTCCTTCATCTTAGAAACCCTCCT

CCCCTTCCCTTGTCCACATTAAAATTGTT

TACTGAAGCTTCTAACCCAGCTCAAATGT

TATATTTTCTCTGTAACTCTCCTGGACCT

TTCTACCTTGAATCCTTATCTCTGCATCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs461599 5 144117124 CTTTGTACTATGAACTCTGTAAGTGCTTC GfT GCTCTGGTAAATTGTCATTCTCTGTATTC SEQ_0256

TCAATGTTTTGCCCTCTCTTTACGTGAGA ACCTATCAGTGTCTTTGATTTTGGGGACA

TGGGATGGCTAGAGTGTGCTGGTGTTGA GTGGTTTGCCCTGTAACCTCACTTCTCTT

GTATTCCCTTTCTCCCACATGGAAGGATA AAGGATCGAAGAAGGGCTGAATTTTCAC

GAAGGGGCTGGAGTTGGGAATCTCTTTC TTTGATCAGC I I I I IACTTCGTGTTAGGG

CCCTAGGTCAGTTAAGCTCTCATAAAACC CAAAGTGGTGACTTCCAAGCTTCTCACAT

CCAGCAGGTTAGGCACTGGTTAAATATTT GTTGAACCAAAAACACAGAGCACCTGAT

TTCCTGACTGCAAAACTTGAGAAGAAGAA ATACMGTTTTAAAAATTGAAACAAATTAA

AAGAATATTCGATATATCTCAAATGGTTC ATATCCTTCCTAAAATGGTTAAATTTACCA

CTΠTCCCCTCCCACTACCAAAAGCACAA TAGTTCGTGGAATATGGTAAGAGAGTAT

GAGGATTTTTCTCTGATATTCACTGTGAG GAAGCAACCACTATAAATGATGTTGTACA

GACTTTGTGGAACTCTAAGAGACAAAGC TACTTATTGACAAAGAAAGATATCTACAC

TCATGAAAGCGTGCCCCCTCTCCTGATG TACTTAACTAGAAAAGAGAGTATAAAATG

ATTGGGTCTCCTTGGAG I I I I IAGCACTT TATTTATACATAATTCTAACTTTGTTTTAA

AGTCTTGTTCACACTGAGCCTCAAGCAAT AAGATATTATATGTGCTAACATATATAATA

TTTTCAATTACAGTTCAGGTTTCCCTGCC TATATATAATTCATGAAATCTGGTATTATA

TTGGCATTGGTTCCCAAAGGGGTTTCTG TACACAAAAATATTAATACAAGTTTTCTTT _M

CTCTTGGGTTCC AGAG £

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS392659 5 144117922 AAGAAATGGGTGCAAGAATATGTACCTG C/T AAGTACAAAGATAGAAATGGAAGGACAT SEQ 0257

GCCATTTTATGCCTACCTTGATCACTATT AGCAAAGATTAAAGCAAATATTAACCCAA TATATCCATCCATCAAACATTTGACGAGC TAGAGAAGAGAAAAACAGTAAAAGAAAAT ATTCACTATGCAGCAGCCATAAGACACAA CAACAAAACTGAGGTTAC I I I I I I I I I I I I AGATAAGTTGTACGTAAGTCCAGTCCTAA TAAAAAAAGACGAAATTGGCAAATCTTTG GTACCCACAATAACAAAGATTTAAGGTGA GCTAGAATAACTAAAAAAGAGAAAAACTC CACTCAAGGTGACTTCAGCAAGATGGCA AAAGAAAATTAGAAATGAAAGAACTGCTG GAACAGAAAGCCTCCTACCCCTTCAAAA CAATAGGCCTTTAGTAATGTGGTGGTAA ACACTATTCAACAACCGTACAAGGATCAA GTTGTGGGCGGAGGGGAAGCTTACTACA TTCCCTTTGTGAGTAATCTAGAAAAAAAT GTCCTGTAATTAGGTCTTGTCTTTTAGTG TAAGAGGCCCCTACCTTTCAGTGCAAAA GAACTGTGCCTTTGTACTATGAACTCTGT CCAACGCCTCTAAGCCAGTAGAAAAATTT AAGTGCTTCTCAATGTTTTGCCCTCTCTT GTGGCATCTACTTACCCTAGCCTCTACCT TACGTGAGATGGGATGGCTAGAGTGTGC ACAGCTCAACGCAGCATGACTGGAGACA TGGTGTTGAGTATTCCCTTTCTCCCACAT AATCCCAGCTCCAGGCTTCTCTCTGGAG GGAAGGATAGAAGGGGCTGGAGTTGGG AGGGAAACAGAAGACAAAATATCCATTTA AATCTCTTTCCCCTAGGTCAGTTAAGCTC ATGTGCAGAATTTCTACCCAACAGCAGC TCATAAAACCCCAGCAGGTTAGGCACTG K* 4- AGAACATACATMTCTCAAACACACATTT GTTAAATAl I I I I CCTGACTGCAAAACTT 'Jl ATAGACCACACGTTAGGCCACAAAGCAG GAGAAGAAGAAAAGAATATTCGATATATC GACTTAAATATAAGAATACTGACATAATA TCAAATGGTTCCTTTTCCCCTCCCACTAC CCAATTATCTΠTTAATAAAATGAAACTAA CAAAAGCACAAGAGGATTTTTCTCTGATA AAATCAATAGCAAAATAAATTTGAAAATTC TTCACTGTGAGGACTTTGTGGAACTCTAA ACAAATATGTTTAAGTTAACAAGATACTC GAGACAAAGCTCATGAAAGCGTGCCCCC CTAAACAACCAATGGGTCAAAGAATAAAT TCTCCTGATGATTGGGTCTCCTTGGAGTT CAAAAGGATAATTAGAAAATATTGAGACA TTTAGCACTTAGTCTTGTTCACACTGAGC AATGAAAGTAAAAACACATCAATACCTAT CTCAAGCAA I I I I I CAATTACAGTTCAGG GGAATACAGCAAAAACAGTGCTAAGAGA TTTCCCTGCCTTGGCATTGGTTCCCAAAG GAAGTTTATAGGGGTAAATGTCTGCATTA GGGTTTCTGCTCTTGGGTTCCTGCTCTG AAAGAAAAAAAAATCTCAAATAATCATCA GTAAATTGTCATTCTCTGTATTCACCTAT GAGCTTTATATCTTAAGAAACCAGAAAAA CAGTGTCTTTGATTTTGGGGACAGTGGTT GAATAAAC TGCCCTGTAACCTCACTTCTCTTAAGGAT CGMGAAGGGCTGAATTTTCACTTTGATC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs455193 5 144118145 AAGAAATGGGTGCAAGAATATGTACCTG AΓΓ AACAAGATACTCCTAAACAACCAATGGGT SEQ 0258

GCCATTTTATGCCTACCTTGATCACTATT CAAAGAATAAATCAAAAGGATAATTAGAA TATATCCATCCATCAAACATTTGACGAGC AATATTGAGACAAATGAAAGTAAAAACAC ATTCACTATGCAGCAGCCATAAGACACAA ATCAATACCTATGGAATACAGCAAAAACA AGATAAGTTGTACGTAAGTCCAGTCCTAA GTGCTAAGAGAGAAGTTTATAGGGGTAA GTACCCACAATAACAAAGATTTAAGGTGA ATGTCTGCATTAAAAGAAAAAAAAATCTC CACTCAAGGTGACTTCAGCAAGATGGCA AAATAATCATCAGAGCTTTATATCTTAAG GAACAGAAAGCCTCCTACCCCTTCAAAA AAACCAGAAAAAGAATAAACCAAGTACAA ACACTATTCAACAACCGTACAAGGATCAA AGATAGAAATGGAAGGACATAGCAAAGA TTCCCTTTGTGAGTAATCTAGAAAAAAAT TTAAAGCAAATATTAACCCAATAGAGAAG TAAGAGGCCCCTACCTTTCAGTGCAAAA AGAAAAACAGTAAAAGAAAATCAACAAAA CCAACGCCTCTAAGCCAGTAGAAAAATTT CTGAGGTTAC I I I I I I I I I I I I I AAAAAAA GTGGCATCTACTTACCCTAGCCTCTACCT GACGAAATTGGCAAATCTTTGGCTAGAAT ACAGCTCAACGCAGCATGACTGGAGACA AACTAAAAAAGAGAAAAACTCAAAGAAAA AATCCCAGCTCCAGGCTTCTCTCTGGAG TTAGAAATGAAAGAACTGCTGCAATAGG AGGGAAACAGAAGACAAAATATCCATTTA CCTTTAGTAATGTGGTGGTAAGTTGTGG ATGTGCAGAATTTCTACCCAACAGCAGC GCGGAGGGGAAGCTTACTACAGTCCTGT K> AGAACATACA I I I I I CTCAAACACACATTT AATTAGGTCTTGTCTTTTAGTGGAACTGT

ATAGACCACACGTTAGGCCACAAAGCAG GCCTTTGTACTATGAACTCTGTAAGTGCT

GACTTAAATATAAGAATACTGACATAATA TCTCAATGTΠTGCCCTCTCTTTACGTGA

CCAATTATCTTΠTAATAAAATGAAACTAA GATGGGATGGCTAGAGTGTGCTGGTGTT

AAATCAATAGCAAAATAAATTTGAAAATTC GAGTATTCCCTTTCTCCCACATGGAAGG

ACAAATATGTTTAAGT ATAGAAGGGGCTGGAGTTGGGAATCTCT

TTCCCCTAGGTCAGTTAAGCTCTCATAAA

ACCCCAGCAGGTTAGGCACTGGTTAAAT

ATTTTTCCTGACTGCAAAACTTGAGAAGA

AGAAAAGAATATTCGATATATCTCAAATG

GTTCCTTTTCCCCTCCCACTACCAAAAGC

ACAAGAGGATTTTTCTCTGATATTCACTG

TGAGGACTTTGTGGAACTCTAAGAGACA

AAGCTCATGAAAGCGTGCCCCCTCTCCT

GATGATTGGGTCTCCTTGGAG I I I I IAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs457077 5 144118219 AAGAAATGGGTGCAAGAATATGTACCTG AAT ATTATC I I I I I AATAAAATGAAACTAAAAA SEQ 0259

GCCATTTTATGCCTACCTTGATCACTATT TCAATAGCAAAATAAATTTGAAAATTCAC TATATCCATCCATCAAACATTTGACGAGC AAATATGTTTAAGTTAACAAGATACTCCT ATTCACTATGCAGCAGCCATAAGACACAA AMCAACCAATGGGTCAAAGAATAAATCA AGATAAGTTGTACGTAAGTCCAGTCCTAA AAAGGATAATTAGAAAATATTGAGACAAA GTACCCACAATAACAAAGATTTAAGGTGA TGAAAGTAAAAACACATCAATACCTATGG CACTCAAGGTGACTTCAGCAAGATGGCA AATACAGCAAAAACAGTGCTAAGAGAGA GAACAGAAAGCCTCCTACCCCTTCAAAA AGTTTATAGGGGTAAATGTCTGCATTAAA ACACTATTCAACAACCGTACAAGGATCAA AGAAAAAAAAATCTCAAATAATCATCAGA TTCCCTTTGTGAGTAATCTAGAAAAAAAT GCTTTATATCTTAAGAAACCAGAAAAAGA TAAGAGGCCCCTACCTTTCAGTGCAAAA ATAAACCAAGTACAAAGATAGAAATGGAA CCAACGCCTCTAAGCCAGTAGAAAAATTT GGACATAGCAAAGATTAAAGCAAATATTA GTGGCATCTACTTACCCTAGCCTCTACCT ACCCAATAGAGAAGAGAAAAACAGTAAA ACAGCTCAACGCAGCATGACTGGAGACA AGAAAATCAACAAAACTGAGGTTACTTTT AATCCCAGCTCCAGGCTTCTCTCTGGAG I R I I I I I I IAAAAAAAGACGAAATTGGCAA AGGGAAACAGAAGACAAAATATCCATTTA ATCTTTGGCTAGAATAACTAAAAAAGAGA ATGTGCAGAATTTCTACCCAACAGCAGC AAAACTCAAAGAAAATTAGAAATGAAAGA K> AGAACATACA I I I I I CTCAAACACACATTT ACTGCTGCAATAGGCCTTTAGTAATGTG ATAGACCACACGTTAGGCCACAAAGCAG GTGGTAAGTTGTGGGCGGAGGGGAAGC GACTTAAATATAAGAATACTGACATAATA TTACTACAGTCCTGTAATTAGGTCTTGTC CC TTTTAGTGGAACTGTGCCTTTGTACTATG AACTCTGTAAGTGCTTCTCAATGTTTTGC CCTCTCTTTACGTGAGATGGGATGGCTA GAGTGTGCTGGTGTTGAGTATTCCCTTTC TCCCACATGGAAGGATAGAAGGGGCTGG AGTTGGGAATCTCTTTCCCCTAGGTCAGT TAAGCTCTCATAAAACCCCAGCAGGTTA GGCACTGGTTAAATA I I I I I CCTGACTGC AAAACTTGAGAAGAAGAAAAGAATATTCG ATATATCTCAAATGGTTCCTTTTCCCCTC CCACTACCAAAAGCACAAGAGGATΠTTC TCTGATATTCACTGTGAGGACTTTGTGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs459807 5 144118339 TGTAAGAAATGGGTGCAAGAATATGTAC C/T TAATGTGCAGAATTTCTACCCAACAGCAG SEQ_0260

CTGGCCATTTTATGCCTACCTTGATCACT CAGAACATACATTTTTCTCAAACACACAT

ATTTATATCCATCCATCAAACATTTGACG TTATAGACCACACGTTAGGCCACAAAGC

AGCATTCACTATGCAGCAGCCATAAGAC AGGACTTAAATATAAGAATACTGACATAA

ACAAAGATAAGTTGTACGTAAGTCCAGTC TACCAATTATC I I I I I AATAAAATGAAACT

CTAAGTACCCACAATAACAAAGATTTAAG AAAAATCAATAGCAAAATAAATTTGAAAAT

GTGACACTCAAGGTGACTTCAGCAAGAT TCACAAATATGTTTAAGTTAACAAGATAC

GGCAGAACAGAAAGCCTCCTACCCCTTC TCCTAAACAACCAATGGGTCAAAGAATAA

AAAAACACTATTCAACAACCGTACAAGGA ATCAAAAGGATAATTAGAAAATATTGAGA

TCAATTCCCTTTGTGAGTAATCTAGAAAA CAAATGAAAGTAAAAACACATCAATACCT

AAATTAAGAGGCCCCTACCTTTCAGTGCA ATGGAATACAGCAAAAACAGTGCTAAGA

AAACCAACGCCTCTAAGCCAGTAGAAAA GAGAAGTTTATAGGGGTAAATGTCTGCAT

ATTTGTGGCATCTACTTACCCTAGCCTCT TAAAAGAAAAAAAAATCTCAAATAATCAT

ACCTACAGCTCAACGCAGCATGACTGGA CAGAGCTTTATATCTTAAGAAACCAGAAA

GACAAATCCCAGCTCCAGGCTTCTCTCT AAGAATAAACCAAGTACAAAGATAGAAAT

GGAGAGGGAAACAGAAGACAAAATATCC GGAAGGACATAGCAAAGATTAAAGCAAA

AT TATTAACCCAATAGAGAAGAGAAAAACAG K.

TAAAAGAAAATCAACAAAACTGAGGTTAC £

I I I I I I I I I I I I IAAAAAAAGACGAAATTG

GCAAATCTTTGGCTAGAATAACTAAAAAA

GAGAAAAACTCAAAGAAAATTAGAAATGA

AAGAACTGCTGCAATAGGCCTTTAGTAAT

GTGGTGGTAAGTTGTGGGCGGAGGGGA

AGCTTACTACAGTCCTGTAATTAGGTCTT

GTCTTTTAGTGGAACTGTGCCTTTGTACT

ATGAACTCTGTAAGTGCTTCTCAATGTTT

TGCCCTCTCTTTACGTGAGATGGGATGG

CTAGAGTGTGCTGGTGTTGAGTATTCCC

TTTCTCCCACATGGAAGGATAGAAGGGG

CTGGAGTTGGGAATCTCTTTCCCCTAGG

TCAGTTAAGCTCTCATAAAACCCCAGCAG

GTTAGGCACTGGTTAAATA I I I I I CCTGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs458366 5 144118496 ACGTTACCCAAGCCCATGTAAGAAATGG CfT ACCTTTCAGTGCAAAACCAACGCCTCTAA SEQ_0261

GTGCAAGAATATGTACCTGGCCATTTTAT GCCAGTAGAAAAATTTGTGGCATCTACTT

GCCTACCTTGATCACTATTTATATCCATC ACCCTAGCCTCTACCTACAGCTCAACGC

CATCAAACATTTGACGAGCATTCACTATG AGCATGACTGGAGACAAATCCCAGCTCC

CAGCAGCCATAAGACACAAAGATAAGTT AGGCTTCTCTCTGGAGAGGGAAACAGAA

GTACGTAAGTCCAGTCCTAAGTACCCAC GACAAAATATCCATTTAATGTGCAGAATT

AATAACAAAGATTTAAGGTGACACTCAAG TCTACCCAACAGCAGCAGAACATACATTT

GTGACTTCAGCAAGATGGCAGAACAGAA TTCTCAAACACACATTTATAGACCACACG

AGCCTCCTACCCCTTCAAAAACACTATTC TTAGGCCACAAAGCAGGACTTAAATATAA

AACAACCGTACAAGGATCAATTCCCTTTG GAATACTGACATAATACCAATTATCTTΠT

TGAGTAATCTAGAAAAAAATTAAGAGGCC AATAAAATGAAACTAAAAATCAATAGCAA

CC AATAAATTTGAAAATTCACAAATATGTTTA

AGTTAACAAGATACTCCTAAACAACCAAT GGGTCAAAGAATAAATCAAAAGGATAATT AGAAAATATTGAGACAAATGAAAGTAAAA ACACATCAATACCTATGGAATACAGCAAA

AACAGTGCTAAGAGAGAAGTTTATAGGG bj

GTAAATGTCTGCATTAAAAGAAAAAAAAA δ

TCTCAAATAATCATCAGAGCTTTATATCTT AAGAAACCAGAAAAAGAATAAACCAAGTA CAAAGATAGAAATGGAAGGACATAGCAA AGATTAAAGCAAATATTAACCCAATAGAG AAGAGAAAAACAGTAAAAGAAAATCAACA AAACTGAGGTTAC I I I I I I I I I I I I IAAAA AAAGACGAAATTGGCAAATCTTTGGCTAG AATAACTAAAAAAGAGAAAAACTCAAAGA AAATTAGAAATGAAAGAACTGCTGCAATA GGCCTTTAGTAATGTGGTGGTAAGTTGT GGGCGGAGGGGAAGCTTACTACAGTCCT

GTAATTAGGTCTTGTCTTTTAGTGGAACT

GTGCCTTTGTACTATGAACTCTGTAAGTG

CTTCTCAATGTTTTGCCCTCTCTTTACGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs374554 5 144118974 ATATTCTTGCACCCATTTCTTACATGGGC G/T ACTTCCTTTTCAGAGCTAGGATCACAGGA SEQ_0262

TTGGGTAACGTAAGGGTTG I I I I I AATAA TTATTTGACCTGTAACGTAGAGATGATCT GTACTTAAAAGTGATATTTGTA I ^"I I I I ATG AGCCAACTCCTCCCATCATTGATΠTATA CTA I I I I I l I I CCATGTTCATCCTTGAAAG CATGAGGAGATCAAGGCCTGGGGAGTTT GAAAAAATAAAGTGCAGAAATCTCCAGGT AAGGGTTGTTCGGAAATCTAATTGTTAGT TGATTTAGCAAAAGCAACTCAGTGGGAC TAGAGGAGGAGCAAGCACTAGAACTAAA TTAC I I I I I CAATACTCATGTCATT GCCACTTTGAGTΠTGCTCTTTCTAAGAT ATCAAACCATGTCTCAGGTCTGGAATAAT TAAGAAGCGTGAGAAATGCCTTAAAATGT TTGAGTACAAAATGCATTTCAAAGGTGAA TTTAATATTCAAAGATCATTATTTCAGATC TCCTGCTGTTAGAGAACAAGGCTGCCTA AAACCCCAGTGTTAACAGATGTCTGCTAA

ATACT rs17791107 144119549 TTTTCTATCATTTTCTTTTGTGAGTATTAA C/G ACTGGGGAGATTAGTTTAAGCTATTTAAA SEQ_0263 TGCATCTGTGTAATACTTACAATTAACAT AATCATTTGCTAGACAGTACATTTTGGTT CTGAAAGAAAATTGAAGAAAAAAGGCTCA AGAGATTTAGGGGAAAATATACTTGTGAG K> AAATAGAATATA AGCAAAGAAATAA Ul

O rs247570 144127404 TATGCAAAGAGGTGTGTTGTAAGGAATC A/G GGGTTTCTATTCATTCTGCTATAATTTTCT SEQ_0264 AGACCTCTGCAAAGACCACCATATAGAA ATCTTCTAACATACTATTTTGTTATATTCC ACCATCATCCAGTAAAATATTACTGTAAG CATTCCTCCAGATTGTTCTATTATCTCAG AAGAAAGCTGTCAGGACCCAAAGGAAGT ATTCCCAGGATGATAATCTTCTTATTTGA TAGGGCTGGGTCTCACACACTTGTCTATT AAAATAAACAGGACTTTCCATCATAGTGA CTGACTCTCTCTGCACATTTGCTACCTTT ATTATTCCCTGTGTAGTGTGTAATTGTTT TCTTCTACTAACCAACTTCCACCCCTTAA ATGGTGTΠTGATATGTGGCAGAA I I I I I 1 1 I I GATATTTCTTA M I N I CCATTG I I I I TATCTGTGGTAGCTCTGTGCATTCTGAGC CTTCCAAAACTCCTAATAGAATATTGGAT TACCAAAGTATTCCTCAAGAGTAGTTAGA CTCCTCATCCTATCACAAATATTTCTTAGT GATTTGCTTCTTCAAGTTGGTCTTGATGG CTATCATTCACA I I I I I I CATGATTTATAG TCAGTAGTTTTATTGTGATAGGTTTTATGT GTTGCTTTCTGGGTAATTGCCTCAGCCTT TAATTTCTTGGCTTATGAACTCTAAATTTA ATCTTTTAGC I I I I I AATGTCTTTTCAGCT ATGGATTCTGAACTTTGTGTAAGTCTGAA ATACCTAATCTGCTGCTTATCCCCTCCAC TTTCTTAAGTGTGATGCTTGTTTATAACAA TGAG I I I I I AATATCAATATCTGTATATTT AAAGTAGTTCCA I I I I I I I I I CTTAACATG TTCA I I I I I AGAAATCC I I I I I I GTTCTTC CTCCTCATGGCCATGTGTCCTTCTTCTCT TACAAACTAGCTTAAGTTTGTGTAGCATT TTATAGTATGGACCTTCTTAGTCTΠTCCT CTGTTATTTCACT GCACCCAGCTGCTGCTTCAG I I I I IAGTT

ACCTATC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs247572 5 144128237 GTACTTAAAGGAAAATATTAGTTTGGGCT A/G CACCCACTTAGCTAAATGGGCTGCAAAT SEQ_0265

GCCAACCAGTTGTTGTAGGAAGGCTGGA GGAGCCAATATTTCTGAAGCCAGTTTTTC

TTATAGCTATCAGAAAAACTCTTGAGTTG TGAGCTTGTGTTATTGAGATAACAAAGAT

AGAAAAACTCATGAGCGGTGGCTAATGC ACCCTTAAATATGCTCTATAGATATTAAA

CTATAAACCCAGCACCTTTGGAGGCAGA GAGACAATAACTATTATTTCTAATATCTAT

GACAAGAAAATCACTTGAGGTCAATAGTT TGTCAGCTAACAAGCATTAACTTCCAAAG

TGAGACCAGCCTAGGTAACATAGCAAGA CAGAAAATTAATTAGCATATTCATGA

CCTCATCTCTACAAAAAAAAAAAAAAAGA GAAAAGAAAAGAAAAGAAAAAATTAGCTG GGTGTGGTAGCATGCATCTATAGTCCTG GCTACTTGGGAGGCTGAGGTGGGAGGA TCCCTTGAGCCTGGGAGTTTGAGGCTGC AGTGAGCTGCAATTGTGCCACTGCACTC CAGCCTGGGTGACAGAGCAAGACTCTAT GTCTAAAATGTTAAATAAATACATACAAA CATAGAAAGTCACAAATTAAAGCTCAGTG

GGAAACATTCAGTTCAAAGTGGAGAGAG _M

CCAGAGTATAAGAGTGGTACAGGCAGTA £

CTTTCTGAGAGATGGCAGCCATGAGGCC AAGCCGGAGGACACTGGGT rs171585 5 144131688 CCCAGGAATCATGCTTTGTGGAGGATGG A/G CACTTTGGAAAACCTTCAGTCTCCCACTT SEQ_0266

AGGCAGGGTGAAGGGCAGTGCGTTGAA CAATCAGGCTTGTAAGGCGAGGCTACTA

AA GAAACTTAATCACACCCTTATGTTAGTCA

TGGTGTTCCTATGGTCAGTACATGCATAA CCAGGAATATGAGTTCAACTAGAAATAAT GCACAAACTAATTCACACACAGGTTGAAA GAAAGAGAGAGGATTCTACAGGCAGAAC ATAAAACAGAGGGGTAATGGTTATATTTC

AGAAAAATCTGAAAAATGGGAAATCTGTG

AGGAGCTGAGCAGAGTAGTTCGTTTTAA

GGTTAGCTGAGTGAAAATTAAAATGTGAG

TGTGTATGGATGTGTGGGTGTGTGGTTT

TCCCAGACAGGCTCCAACTTACCATTTGT

CTTTATGGGGATGATTGGCTTTTGGGTTT

ATGTCTACAGGCTCTGGAAGGAAGGCCT

GGGAGTTCAGTGGAGAGCTCACTGAATT

TGAAGGCTTTGGGCCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10065170 5 144135783 CATGAGAAGATTAGATAGATAGATGATAG G/T TTATTCAGATAATTGCCTTATCTTGCTCAT SEQ_0267

ACAGATAGATAGACAGATCTATTGATCTT TTAGTTTGCTTGTGGAAGAGGAAGAAAAA TGGTGTGTGTGTGTGTGTGTGTGTGTGC ACAGCCCTTGTGATTCAGAAAGTTCAAAC GTGCATATACACCAAATAACCAGCCTTAT ACAACATTAAATTGCTAAGATAATTGCTA TCCGACTAGCTTTGGGACTTTGAGACTTT ATTGGCGAGCTTACATCACAGCATCCCA GAGCAATTGACTTTACCTCTCTACTAAAA TTCGGATCAATAAATTCAATGACCAAAAT TTGTAGTTTTATCATTGTTTAAAACAGGAT AATGTAACTACAACTAAAACAAGAAG AATGATAACTAGTTAAAACAGGTATAATG CTACTTCACAGCATTCTTACACACTCAAA ACATATAAAATTGTATGTGCTTGAAGAAA GATTGTGATCATTTATGAATATGAGGAAT TGGATTTAGTAAATGGCCTCCAGA rs3906524 144136573 TGAAAACTAGGGTTCCAAGAAATTAGGTA A/G TCAACA I I I I I AGTTGCCTTATTAGGCTTT SEQ_0268 CCTTGCTCATTTATTAAGGAGCAGAGCCA CTAAAAGTCAAGGCTTTGAAATTTAACTC AAAATGTGACTTTAGGACAAATTCATATG TTAGAT

CTCATGTCACACA i I I I I ΓAAATGCGTCT 1» Ul

TTATAGTCAGTTAGCCACTTTGAG I I I I I I K>

AGAAATTCCAGAAGAGTGTGAGGATCAT

ATACACTGCC I I I l I CTTTTCTATCTCTAC

TTTTAAGTATATACTAGTGTTCCAAACCC

TATTTCAGAATGGATATTGAGCCAATATT

TGAGAAGCCAATGAGTCCCAAGCATTGC

ATTTGATGTGATGA I I I I IAAAAATGAGG

TTAGGCAGAGTTTCTGCCCACAGGAGCA

TATTATTTC I I I I IAGTCAGTTCGTAACAC

ATGCTGC I I I I I I GTAGGTACTCATTGAA

TGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs118783 5 144138729 ATAATGCCAAAGATACTGAAACTACTACC C/G I I I I I CCCCATTGTAATCCCTTGCCCTAA SEQ_0269

ATTGGCCGTGCATTTCAGAAACTAGTTAG ATAAGAAGTCAGATCTGTGTGTGCTTATT CCACACTAACCCAATCAAGAATTTCTGTT ACTCAGTGGATTACACTATGGGCTCAGT GAACAGGAATTGGATGCAAAAAAGCCCC GTTCGGTGACTTCGGGTAGTATTTTACAA TTCATACTGTTTCAAATAATAAATGTACAT TΠCCMCTATATTTTCTGCTTTATAAATG GTTTCCATGAATGCTTATAACCTGTGATA TCTCCTAGAATATTTCATTAGGCAAATTA TTTCCCTCAATATGT GGCTGACTCCCTGACTGATCCTTTGTAAT TTGTAACGTTTTATTGCTTAACTATAGACA TAATTAGGGATGCCTAAAATTCTGACTTT GAACTAAGAGCAGTTTCAGGCATAATGT CGTTACCTCTTGGGCCATCTTCTTCTTTT CTCTAGATTGGAAAGGGCTCGACTAAGA CCCTTGGAAAAATATGTGCTTCCGTAGAA AAGCCCTTTTCCACCCAAGGGCCTCATT CTTCATCTGTAAAATGATGGAGTTAGACT AAGGGACCTTTAATGTCTCATTTACATCT GTGTCCATGTGTΠTAGAGGAAATGACTT K> TCCTCTCTGAAGACTAATAAGAAAGAATG ACTGGTCTGATTCTACTAGACTTACTCAC ACTCACAGGAACAGGCAGAATATGATAC AAGGCTCTGGGAGGGAAAAGAGAGCAC CCTCATCTCCAGAGGCCTCAGGAGAGTT TGGCATGTGACGCATACAATCGAGCCCG GAATTAATAGTACTTACTCCTCACTTAGT GCTTATAATGTGCCCATAACTACAACCAG TGTTTTATATTTATTACATTTATGACAGCC TCAGGAAAATGTTATCATTGCCTGTATTT TATAGATAATAGGAATGAGTCTTACAAAG AATAAGCAACATGGCAATTGTCATTGGG CTTTTAAGGAGTTGACATGGATACAGACA GATTCTATCCATCTCAATAATCATGCTATT CTGTCTGGTCATΠTATCATTTCATTCATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs118784 5 144138771 ATAATGCCAAAGATACTGAAACTACTACC AJT TCTGTGTGTGCTTATTACTCAGTGGATTA SEQJ3270

ATTGGCCGTGCATTTCAGAAACTAGTTAG CACTATGGGCTCAGTGTTCGGTGACTTC

CCACACTAACCCAATCAAGAATTTCTGTT GGGTAGTATΠTACAATTTCCAACTATATT

GAACAGGAATTGGATGCAAAAAAGCCCC TTCTGCTTTATAAATGTCTCCTAGAATATT

TTCATACTGTTTCAAATAATAAATGTACAT TCATTAGGCAAATTAGGCTGACTCCCTGA

GTTTCCATGAATGCTTATAACCTGTGATA CTGATCCTTTGTAATTTGTAACGTTTTATT

TTTCCCTCAATATGTC I I I I I CCCCATTGT GCTTAACTATAGACATAATTAGGGATGCC

AATCCCTTGCCCTAAATAAGAAGTCAG TAAAATTCTGACTTTGAACTAAGAGCAGT

TTCAGGCATAATGTCGTTACCTCTTGGGC

CATCTTCTTCTΠTCTCTAGATTGGAAAG

GGCTCGACTAAGACCCTTGGAAAAATAT

GTGCTTCCGTAGAAAAGCCCΓΠTCCAC

CCAAGGGCCTCATTCTTCATCTGTAAAAT

GATGGAGTTAGACTAAGGGACCTTTAAT

GTCTCATTTACATCTGTGTCCATGTGTTT

TAGAGGAAATGACTTTCCTCTCTGAAGAC

TAATAAGAAAGAATGACTGGTCTGATTCT K.

ACTAGACTTACTCACACTCACAGGAACA £

GGCAGAATATGATACAAGGCTCTGGGAG

GGAAAAGAGAGCACCCTCATCTCCAGAG

GCCTCAGGAGAGTTTGGCATGTGACGCA

TACAATCGAGCCCGGAATTAATAGTACTT

ACTCCTCACTTAGTGCTTATAATGTGCCC

ATAACTACAACCAGTGTTTTATATTTATTA

CATTTATGACAGCCTCAGGAAAATGTTAT

CATTGCCTGTATTTTATAGATAATAGGAA

TGAGTCTTACAAAGAATAAGCAACATGGC

AATTGTCATTGGGCTTTTAAGGAGTTGAC

ATGGATACAGACAGATTCTATCCATCTCA

ATAATCATGCTATTCTGTCTGGTCATTTTA

TCATTTCATTCATTCAATACCTAAGTATTC

AGAGCTTGCTTCTTACTGGGATTGATCAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs10071219 144144542 ATTGAGTAGGTGGTTGTTTGCTGGCTAG A/C GAAGAGTTTTGCAACAGAAGATAGCAAG SEQ_0271 GATTTGTGAGAGATGTATGGCTAGGAAA AAATGGGCTGGAAGCTGACAAGAGAAAT CCCAAATTTGGGACTTATCAGCACAGAG TGAGTAATAAGATGGGAGTAATAGTAACA ATAGTAAAGAAAGTATCAGATTGGATGGC TTTGCATAATAATGAGAATGATACGACAG TTCACCAAGGGAGTGAGCACAGAGAAGT TGAGTAAAACATATATTGATAATGTAGGA GAAGAGGGTTCATGACTGAGCACCAGAG GGGTCAATTTCTGTAGAGTTGTTCTTAGG CACTGCAATATTAGGAGGTTAGGAAAAG TAGATAAAAAGAAGTGAAATTTAGTATGC AGAAGGAACTATGAATCTACGAAGGGGG AAATGGAAATATTAGCTTTGGAAGGGAG AGCCAGTGGCATAAGGGGAAACCAAGAG CATGGATATTTTCTCTACAATTATAGGAA CACACCAAGAAAGTGTGTTGTTGCAAAAT GGAAAGTAGAGTATACGGGTTCAGATGT TCAAAGGAAGATAATGTATCAAGGGAATA TGAAGGTGGGTAGGCAGCTCTGGAGATG GAATAATCAATTGTGTAAAATGCTGCTAG CTTATCTGTATAAGGTCTCCTACTGTTGC TAAGTCAAGTAAGATGAGGACTGAGAAT ATTAATATTCTTAGTGATGTAGGACACAT AGACTATAAATTTTAGCAAGAAGGAGGTC GAAGACAGAATCAGTTTCCATATCACTTA ACTTGTGACGATAATATGCCCAGTTTCAG GAAGGTGTATACTTTCAAGTAAGCAATTT CAAAGCCAAATTAAAGTAATTTTAAGAGA AATGTCTTAGAGTCTCAGATTCTTCATCT GAATATGAGGAGACTAACCAGAGACAGT GTGAAATGGGAATAAAATATTTGTGTTTA Ul AGGACAGACATGTTTTC TGTTCAGTAGTA 'Jl rs4913000 144148365 CTTCTACCTCTCAAGTGTATGCATTTTAA G/T GGCTGAGGGTGCTCATTAAGTAGTAAAT SEQ_0272 ATTGCCCTGGCACCCAGAACAATCCTAG ATTTACAAGTTGGAGAAGTTAGAATTGTT ACAGTTGTCAATGCTAAATAATTGGTGTA AAATGGCTAGTTGAACATCACTGAGCAT TACCTGAATTGATGTCTTCTGTTTAATTGT GGCAATTTGTGGAAAGATGGCTGAGGCA TAATGACAACCAGACAAATTCTACAAGCT GATGTCCCTGTCACAGACGGTCTTTCAA CACATCTCCTTTGAGAGAGCCACAGTTC AATAGTCAGAGCGATGACTGAGAATTGC C I I I I I CTCTATGTCTTAATAAATATA CAACTGAATGCAAGGAGAAAGAGTAAAT TCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs248558 5 144155536 ATCATGAGAAAAAGCAAGGCTGCCTCCT A/C TTATCTGAACCAAGAGATTAATTCAGATT SEQ_

GCCAAATATAACTTATTTATTAGATGTAG ATAGAATAAATCAAAC I I I I I I AAAAAAAT AAAAAGAAAAGAACCTTCAGGAGTTCACA GTATTATTCTGCTAATTTGCAAATATCACA GACAAACAGAGATTGCTGGGTCCCTGAG AATTCATGAATGGCTGTTAGAGACAGAAA AAAGATATTCTGTAATCTATTTCATAGGC AAGTAACAGGTCAG AAAACCCCAAATGGATATGCTGGATCCAT GAGCAGTTCTTTGCTTCCTAAGTAGATCC CAAATAGAACCAAGAGAGAAGACATGAC TTTCTGTTGGTTCCAGACAGGCCTAAAAT GTTAGATTCACAGTAATTTCCTCACTCCA TTGTGATGCTGAAGCCAACTTGTTCCTGT GATAAGGTAGATTCTGGCAATTTGAGTTA TTCTATCAGGAATATATGAGGTGATATAT TCACACACATGAAAAGGAAAATGTTACTG AGTGAAAAATACTTCTA I I I I I AACTAATT TAAAACATTTTAGTGTTCATTGTTTGAATA ATGAAAGGCCTGTGTATATCTACA I I I I I K* AATAAA Ui rs248557 5 144157508 TGAAGCCACACCTGAGGCTGGCTGCATC C/T TCAAGTACTGGATTAGTCTCTACTAACTC SEQ 0274

CCCACAATGCAGCACCTCAAGTTACTTTA TATGACTTTGAGCAAAGTCATTTGTCTTC TTCTTTACCTCTGTTTCCCTCATGAAGCA GTTGATCCCCAGTTTCTTTTCTGTAAAGT GTGGATTTTGCTGAAAGCCAGCCTTCAG GGATATGACAACAGCATATATACTATAGA ATTTACTCAGATCTATATAAATTATGTAGG A I I I I I AAAAGGATTAAATGAGATCATGC AAAAGCAATGACAAAGGAAAAAAGAAGA ACATAAAATGTTCAGGGCAGTGGCCAGA GAGGAAATTAAGTATATAGAATGTCAGCC ATATTATAAAGACAGTAAGCAAACAATAA AATAACCCATAGGACAAAGGGGATATTAA ATGCCAGTTATTATTATTACTATTATTTGA GGGCACTTTTAAACTGAAAATTCAGATTC GACAGAATCTCACTCTGTCACCTAGGCT TTCAGAAAAATGTAAAGTCCTCTAGATTC GAGTGCAGTGGCATGATCATGGCTTAAA ATGAAAAGGATGATGAAAATAGGAGTGA GCAGCCTCAACCTTCCAGGCTTAAATAAT TTTATTTTCCTTCACTAAGTTAAGCTTCCC CCTCCTGCCTTAGCCTCCAGAGTAGCTA TAAGCAGGTGCCGTCTTTCCCTCCTATAT GGACTACAGTCATGTACCACCATGCCTG TGGTGGCATGTAACATATGTTACCTTGAA GCTA I I I I I I I I I CAGAGATGGGGTCTTG TTATTGTTATTTGGGTATTTGCCTACTCCT CTATGTTGCCCAGGCTGGTCTTTAATATC CAGTAATATGATAGAGGCAGCCAGGCTT TGGACTCAGGCAATCCTCCTGCCTCAGC TGTAGTGGAATACATGGGCTTTGTGGTC CTACCAAAATGCTGGTATTACAGGCATGT AAATAATTTG GCCACCTCACCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS248556 5 144157532 ATCAGAATGATGAATTCAGCCAACTGAAG CH^" GGGCTTTGTGGTCAAATAATTTGCTCAAG SEQ_0275

CCACACCTGAGGCTGGCTGCATCCCCAC TACTGGATTAGTCTCTACTAACTCTATGA AATGCAGCACCTCAAGTTACTΠΓATTCTT CTTTGAGCAAAGTCATTTGTCTTCGTTGA TACCTCTGTTTCCCTCATGAAGCAGTGGA TCCCCAGTTTCTΠTCTGTAAAGTGGATA TTTTGCTGAAAGCCAGCCTTCAGATTTAC TGACAACAGCATATATACTATAGAATTTTT TCAGATCTATATAAATTATGTAGGAAAAG AAAAGGATTAAATGAGATCATGCACATAA CAATGACAAAGGAAAAAAGAAGAGAGGA AATGTTCAGGGCAGTGGCCAGAATATTA AATTAAGTATATAGAATGTCAGCCAATAA TAAAGACAGTAAGCAAACAATAAATGCCA CCCATAGGACAAAGGGGATATTAAGGGC GTTATTATTATTACTATTATTTGAGACAGA ACTTTTAAACTGAAAATTCAGATTCTTCA ATCTCACTCTGTCACCTAGGCTGAGTGC GAAAAATGTAAAGTCCTCTAGATTCATGA AGTGGCATGATCATGGCTTAAAGCAGCC AAAGGATGATGAAAATAGGAGTGATTTAT TCAACCTTCCAGGCTTAAATAATCCTCCT TTTCCTTCACTAAGTTAAGCTTCCCTAAG GCCTTAGCCTCCAGAGTAGCTAGGACTA CAGGTGCCGTCTTTCCCTCCTATATTGGT CAGTCATGTACCACCATGCCTGGCTATTT GGCATGTAACATATGTTACCTTGAATTAT TL I I I I CAGAGATGGGGTCTTGCTATGTT TGTTATTTGGGTATTTGCCTACTCCTCAG GCCCAGGCTGGTCTTTAATATCTGGACT TAATATGATAGAGGCAGCCAGGCTTTGT CAGGCAATCCTCCTGCCTCAGCCTACCA K> AGTGGAATACA AAATGCTGGTA rs389997 144162238 ACAATTTGA M i l l CCATCACTTTCTCTTT A/G GGCCTTTGCCCATACCTGGCTCAGATAG SEQ_0276 TTGAAACGAGTCTGGCTTAATATCCATGG AAAAAATΠTCACCAAGTTTTATAAATGTC CTTCAAAAGTTTATATAATAGAAAGAGAG AACCACCATTTCAATGTTTTATACATATCT AAAAGATAGCCCTGTTTCAATCTACCAT C CTTCTAGTCCTTGACATTTCAGTCTCCCT TTCAAACAAGATACTTACCTG I I I I I CTAC AATATTAAAGACTGGGGCAAATGTGTAAC CTCTTTTAAAAATCTTGACCTGGTGTGGT TTACCGTTGTACAAGTGACTTCCATTTCA AGCTCCACCTGTAATACCAGCTCTTTGG GATTGGCAGAGTAGCCAGGACCAGA GAGGCCAAGATGGGGGTCTCACTTGAG GCTCAGAAATTTGAAACTAGGCTTGGCA ACATGGTGAGACCCAGTCTCTTAAAAAAA TTATCACAGATAATATAATAAAAATATGGA TAATTATTAGATAATTATATAGGATATTCA TAATATTGGAGTGAAATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs173572 5 144162907 TGATAATTTGTGGAATGATCTCCGTATCT C/G TTCAGCTCATATGTTTCTGGATTTTCTCTA SEQ_0277

AGCAGAATAGAGAAACCATCATGGAGTT TTCTAGCATGCTCAGGTACACACACATTT

GCTAATGAGATAATGATGATGTTGGTAAT ACACATGTGCACAGTTG I I I I I IACTAAA

AGCATAATAAGAGGCAGTGTATATGGTAA GTGAGGCCATATTGTACACACTGTTATAT

TTAAGTAAAAGTTATTTGCATTCAGACAG ATATATTTAGATTTACTTCCTATTTTCCCC

ATCTAGGCTTTGTCTTATGTCCCATCATT TTATCGATACCAAATATCCTTTGTAACTTC

TGCTAGCTATGTCCCTGGGCAACTTGGT TTTATCTAAGCCAGTATCTAATC

AAACCTCTGTGATCTTCAGTATCCTCATC

TATAAAATGTAAATAATAATAGTACCTGCT

TCATAGGGATTTAATGAGGATCAACTGAC

ATGATGTTTCTACAAAACTTATCACAGCG

TTTGGCATACTTAATGTGAATTAATGTTG

I I I I IAATTGCCACTGTTATTATTAGTCTA

TTTGCACTAATCAACCATCAAGTAATTTG

TGGTGCTGAATACCTTAATCTAAAATATC

CTTATGTATTTATTTATATTTAAAATAATCA

TΠTCATTAACACACAATCAGAATTTGCC K>

CATGGTAGAAATGTTGAAAATAAAGACAA

GTGACATTGTTAAAAACAATAATAATAAT

GATAAAAACCTTGCGTATCTACCAACGCA

GATCTCAACTGATAATAT rs248568 144163286 TCCATGTTCAGCCACTTATTAAAACGTTT AfT TCCTCATCTATAAAATGTAAATAATAATAG SEQ_0278 TTATTCCTACTTTCCAATTTTCTGTATTCA TACCTGCTTCATAGGGATTTAATGAGGAT AGAACTTAGCAGGTTG I I I I I l I I I I IAAT CAACTGACATGATGTTTCTACAAAACTTA GTAACAGACACTGATAATTTGTGGAATGA TCACAGCGTTTGGCATACTTAATGTGAAT TCTCCGTATCTAGCAGAATAGAGAAACCA TAATGTTG I I I I I AATTGCCACTGTTATTA TCATGGAGTTGCTAATGAGATAATGATGA TTAGTCTATTTGCACTAATCAACCATCAA TGTTGGTAATAGCATAATAAGAGGCAGT GTAATTTGTGGTGCTGAATACCTTAATCT GTATATGGTAATTAAGTAAAAGTTATTTG AAAATATCCTTATGTATTTATTTATATTTAA CATTCAGACAGATCTAGGCTTTGTCTTAT AATAATCATTTTCATTAACACACAATCAGA GTCCCATCATTTGCTAGCTATGTCCCTGG ATTTGCCCATGGTAGAAATGTTGAAAATA GCAACTTGGTAAACCTCTGTGATCTTCAG AAGACAAGTGACATTGTTAAAAACAATAA T TAATAATGATAAAAACCTTGCGTATCTAC CAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs248567 5 144164494 ACCCATCTACTAAGCCTAGTACCCAATAT A/T CTTTGAAGTGGCAGTGGGAAAAAATTAAA SEQ 0279

TTA I I I I I I I CTGATCCTCTCCCCCCTCC GTATGAATAGAATTTATTAAATTGCAACC CACACTCCACTGTCAATTTCCTGTGTTCG TAAATTTAAACTTTTGTCTC I I I I I CTCCC TTTGCTAAGGATAATGGCCTCCAGCTCC TGTCTCCATGCAATCAATAAAAATTACTA GTCCATGTCCCTGCAACGAATATGATCTC TAGCCCAAATGTCAATGTTCAAAATAGGT C I I I I I I IATTTAATGGCTGTATTGTATTC CTAAGGGTTTCCAGAA I I I I I I I I I I I IAA CATGGTTTATATATACCACATTTTATTTAT I I I I IATTGTGCCTACCTAAAATCTCCAG CCAGTCTGTCATTGATGGACATTTCGGTC TCAAGGCAGTCCATATACCAACTGATTAG GATTCTATGTCTTTGCTATTGTGAATAAT TTCTGTCCACTCTTGAAATACTTTTCTATT GTTGGAATAAAAATACACATGCATGTATC ATTTCTTAATTGTCCTTATA CTTATAATGTAATGATTAATATTCCTTTGG GTATATACCCAGTAATAATATTGCTAGAT CAAATGGTATTTCTGTCATTATG I I I I I GA GGTATTGTCACACTGTCTTCTACAACGGT TGAGTTAATTTACACTTCCACCAACAATG TGTAAGCATTTCTTTTCCTCCACAACCTC ACCAGCTTCTGTTATTTTATTTATTTATTT K> ATTTATTTTGAGATGGAGTCTCGCTCTGT CACCCAGGCTGGAGTGCAGTGGTGCAAT TTCAGCTTGCTGCTTCCTCTGCCTCCGG GGTTCAGGCAATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGAATACAGGTGCGCA CTGCCGCGCCCAGCTAA I I I I I I GTATTT TTAGTAGAGACAGGGTTTCACCATGTTGT CCAGGATGGTCTTGATCTCCCAACCTCG TGATCCACCCACCTCGGCCTCCCAAAGT GCTGGGATTACAGGCATGAGCCACCATT CCTGGCCCAGCATCTGTAA I I I I I I GACT TTTTAATAATAGCCATTCTGACTGGTGTG ACGTGATATCTCATTGTGGTTTTGATCTG CATTTCTCTAATGATCAGTGACGTTGAGC I I I I I I I CATTTGCTTGTTGGCTGTGTGTA rs482011 5 144171104 CTCTACTATATCTGGCCTGTTAGGAGAAA A/G TCCACATCCCCATTACCTTATGTCTAACC SEQ 0280

ACTTGTAATC I I I I I CTCAAGTATAAAGAT AATGG I I I I IAAGATAATAI I I I I GGCAA GGAAACCTAATAAATTCTGAAATACACAC GTTCTCTGTCTTCAATGAGAGAAMTTTT GATTACTAAATATACAGC I I I I I ATGTAAA GA I I I I I I GTAACTGGAGTTTATATTATTC TTAACATTGTATAATAATTTACTAAAGTGG TACAAGATTAAGGTAAAGTGACTCACTGA TGTGCCTATAGAACAAATGTTCATAGATT AAATATTACATTGACTACTGTTATGGTAAT AATGTTTCAGGTAGATGAAGTTT ATTTTATTGTCATGGCACTATTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs423327 5 144172332 CACTGGTTGTGAACAATGGTTTTGCGTAT C/T GTCTAAAGGTGGGAATTTTCAATTATATA SEQ_0281

CTTCAGAAGTAAATTAACATGTTTAATCT AACAGTTCTAGGCCCGCATATGGCAAGG GTTACATTGGCATCTCCCAATATAAAAGT GGGGATGGTCAATAAAAGGGTATTTAGC AAAACCTAGTTACAATTCCCCAGTGTTCC ACAGATACTAACTCCTTATATGGACTAAG AAGGGATCCACATTAAAAAATAT I I I I I C GAGAGACTTTTCCAGAAAAGTGAGAGGA ACCAGCGCTTACTAAATTCAGACCAAGC ATGTTCTTACCCTTTGTTTTACTGTCCTTA AAGTTAACAGAATCACTCCTAGTTGTC GGGCAGAATTTGTTGGTCTTTCACTTTA rs 10041348 144173087 AG CAAAAC AGTTTTATTG I I I I I I CTTATG A/G CTGTGCTTGTTTCTGTACTTATTTCACTG SEQ_0282 AACTCAAACTTACTATAATGACTTGGGTA AGGATTCAAAGTCTTAGAAAAGAAGAAGA GCATAAGAAATGAAACATAAAGAGGTAG GCCCAGCTAGGCTCACTTAGGTGAAATG GCTCAAAAAGAGTGAAATAATAGGAGGA AAAACCATTTATCCAGGGTCGGGCAAGA TTATATCATTTTTGAAGACATATGCTACA TATC I I I I I I GGTAATCTCATCAAAACTGA GGGAGTAGTTTGATTAATATACTACGTTT AGTCAAATAI I I I I GATCTTTTCAAAAGGA TGGGGCCATCGATGTTGGCATGAATTC TATCAGGGGACTTCTACTAGAACAAT rs12189216 144176803 CTTAATAGGAGTGATGGTTGTGATGGTTA C/T TTTTCATAATAAATCTATTTCCCATTGGTT SEQ 0283 K* ATTTCATGTGTCAACTTGACTGAGCTAAG CTGTATCTCTGGAGAACCTTAACTAATAC O GGATGCCCAGATAGCTAATAAAATATTAT AAAAAGGGTTGGTGGTGATGTTGCCATG TTCTGGGTGTGTCTCTGAGAGTGTTTCTG TGGACAGCATTCATTCACCCATTCTGGTA GAAAAAATTACCATTTAAATCAGTAGACT CACTGCCCTCTGTCACTTTAGCA I I I I TA TAGTAGAGATCCCCCTACCAATTTGGGT TTTCCTTTTATTCATATTTAGGTTCTAAAT GGGCATCATCTGATATA I I I I I GGCCTTA AAAATGAACAATATCCTGCTTCTGCTTCA ACAGAACACAAAGGCAAAATGATGATTTT TATGATGCCACTATCTCATACACAACTGT TTTACCCCTAATAATAATATCCCATGGAA ATCTTTTCCACATACAGCTGAAGACAA ACAAATGTCTCATTCTCATTCTCTCTCTCT CTTTCTTCCCCTCTCTGCTCTCTGCTTGA GCTGGGTCATTCATCTTCTCTTTCCCTCA GACATCAGTGTTTCTAGCTCTTGGGTCTT TGAACTTGGACTGGGACCTATATTGTTGA CTTCCTGAGTTCTCAGACCACAGGTΠTC CTGGGCGTCCAGCATGCAGACAGCAAAT CATAGGAGTTCTCAGTCTCCTTACTTGCA TAAGACAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs990701 5 1₄4177471 ATGAAGGGTA I I I I I AGATGAAACTGACT AfT TTTGGTTTCTATTATTTCAGTGGTTTTAAT SEQ_0284

TTTAAAATGATAAACTTGGGGTAAAGTAG TCCCAGAGATTTGATTTATATCAAACCAG

ATTGTAGTCCATAATGTGGGTAGACTTCA CATACTGAGTTCCTTTCTCAGGGCAAAG

ACCAATCAGGTGAAGGCCTGACTAGAAC GAAAAATGGAGTGGAAAGTGGAAGAAAG

AAAAAGACTGGCCTCCCCAAGGAAGTGG AAGTTATAAGTATGAATCATAAGACCAGT

GGGATTCTCTAGCAGACTGCCTTTAGATT TCAGAAACAAAGACTGTAATCATGTTGTG

TCATCTGCACTATCAGCTCTTCTGGGTCT AA I I I I I I GTTTTCTTTGCTATTAATATGTT

CTAGCCTGCCTGCTGTTAGACTAGAACC TGCATATATTTGTTA I I I I I l CTCTCTCTC

ACAACTTGCTCTCCTGGGTCCCCAACAC TCAGCCCCATACTATCTAATGTAAATGTG

GTTGGCCCATAAGACAGA I I I I IAACTTG ACAATCACATTTCAACCCACATCTCAGTA

TCATCATCCATAATTACATAAACCAATTC TCTAAGTATTAGAATATCAAAGCCGGAGT

CTTAAAATTAATAAATATACATACATACAT AAAACTCAATTGGAAGAGCAATAAGTTTC

ACATACATACATACAACATCTTGATTCTG TCCAAAGAT

TTTCTCTGGAGAATCCTAACTAATACAAT

ACTTTACAATGCTTCCCATGATΠTCTCC

CCCTAATAATATCCCATGGAATATCAACA

GTTTCTTTCTCTCTCATTACAGGATTTGA ^

AAAGGACATTACTATGACATTTTCAGCCT 2

TAAGGAAAATAATTCTGAATTATCAAGCT

TGTAGTTA I I I I I I ACACAGCAATAGAAA

ACTAATATATGCCTGTCATTATTAAACAG

AATGAGCTTCTAAA I I I I I I I CTCATTAAC TCTGCAA rs4577727 5 144179960 ATCAACTTACTTTATATTTCAGGACTTTTA A/G TCTTCTAGTGGGGTGCAGAGATGGTCTT SEQJ3285

AATGTATCTGTGTGAATATAGCAGGCAGA CTGAGGAAAATTTCA I I I I I GTCATGAAA

TTTGGGTGCTCCACCCAACATCAATTCCT GGAGCAGTCACCACTTGTACTAC I I I I I I

AATTCCATTCTCCTGGCCATCTCCCACAT TTTGTTCCTTCTATTCCCATCTTCCTAATT

AAAACCAAAAAAACCTAAAGTCACTCTCC TGAATACAAGTGTGAATCTTGGATCTCTG

TGGTCTACCTTGGAGGCCATTTGACTTΔ, GAAGATATCCTGAGACTTCCAGAATTAAA

GCTATGTCAAGGAAAAATCTGTGGAT GAACAACAAGCTAAATGTAGTGGAGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2400162 5 144181032 TATTTAAGACAGAGAAATAAAAGTATCCT A/G AAAATTGTGACCACATAGCTTTTAAGTAG SEQ 0286

GTAGTATTCTCCAATGTGTTTCCGAGCTA AAGAGCCAGGGTTCATACTGAAGTATGA AAGTAGCTCATCCTCCTTACTGTCATCAT CTGATTCTAAAATTTATG I I I I IAGTCACT GGCTCAGCTTTTACTGAGTACTCATTGTG AGGCCTTTCTCTCCCCAGGAGGCACTGG AGTTAGGTACAGACTTATACACTTTATAT AAACATAAATAACAACCATAAAATGTTTTT GTAAAATGTATTCATTCCTCACATCACCC ATTCCCTGGGGAGGGTCTGTAGGGGGA CCTCATCATATCACATCACATCAACACAG GACCAATAAGGAAATAGTATΠTC I I I I I CATTATTATTTTTACCTCTTGCAAATGGG C I I I I I C I I I I I I I I I I I I I I I I I I I GAGAT

AGAGTTTCACTCTTGTCACCCAGGCTGG AGTGCAATGGCGCGATCTCGACTCACTG AAACCTCCACCTCGCAGGTTCAAGCAAT TCTCCTGCCTTAGCCTCCCAGGTAGCTG GGATTACAGGTGCCCACCACCATGCCCC ACTAA I I I I I G I I I I I AGTAGAGATGGGG TCTCGCCATGTTGGTCAGGCTGGTCTTG AACTCCTGACCTCAGGTGATCCATCTGC ATCAGCCTCCCAGAGTGCTGGGATTACA K* GGCATGAGCCACTGC K> rs2214997 144182082 AACTGTCACGTTTCAGTTAAAGGGATTGG AFT I I I I I I I I I CTTTCCATTGCCCTACTGTTC SEQ_0287 GGCTGAAATCCAGGAAATAGACTTTGAAT ATATTCAGCTCATTAGTCTTGAACTAACA GT TAGTAGAATGATCTTTTAGGGAATTTAAA TCACTTGAACAATACTCATTCCAGAGTTT CTGTAAAGGGTAGCATATGTCCCTAGTAA AATCTTTAATATTAATGGTCTCAATTATTC CTTTGTTTTCTTCAAGGACACAACCAGTG TGACTCTGTTTCTCAAAGGGTAGGGAGG AGTCTATTTGGAGACCAGGACTTCATTTT CCTCCTACCCATGTCAGCCTACTTGTCCT CTGTCATGCTATCTTCATTATAAAGCAGC ACCCAGTAGTCTACAGAAAATGTGGCCT AGGAAAAATCACAGAACAGCATACCATAA GAAGCAACAACATAAGAAAGGTCACACA TACAGACATACACACACACACAAATTTTA ATATCCTCTTAGCAAAATGTGAGATCAGG ACACAAATGAGACATTGAAATGGTGTAAC TTTTAATCCTΠTGCATTACCATATCATAG TGTTAAAAATAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs248577 5 144182754 AATCTACGTCTGATTGGTGTACCTGAAAG A/G ACATAACTTACCCCAAATCCGTGTTTTCC SEQ 0288 3

TGATGGGGAGAATGGAACCAAGTTGGAA TTCTTTTGGCAATGAATAAATTGGGTTGA

AACACTCTGCAGGATATTATCCAGAAGAA TAAAGAAGGTTGTTTCCAAATCTCACACT

TTTCCCCAATCTAGCAAGGCAGGCCAAC TAGGGTGGACTATTAAGTCACTACATGCT

ATTTACATTCAGGAAATACACAGAACGCC ATCTCTTACAGGATAAGATCATAAAAACA

ACAAAGATACTCCTCGAGAAGAGCAACT AATTAACAAAATGAGTAAATAAATGACCA

CCAAGACACATAATTGCCAGATTCACCAA AGAGATGTATGGTTTGCCTTGTAAAC

AGTTGAAATGGAGGAAAAAATGTTAAGG

GCAGCCAGAGAGAAAGGTCAGGTTACCC

ACAAAGGGAAGCCCATCAGACTAACAGC

GGATCTCTCGGCAGAAACTCTACAAGCC

AGAAGAGAGTGGGGGCCAATATTCAACA

TTCTTAAACAAAAGAATTTTCAACCCAGA

ATTTCATATCCAGCCAAACTAAGCTTCAT

AAGTGAAGGAGAAATAAAATACTTTACAG

ACAAGCAAATTCTGAGAGATTTTGTCACC

ACCAGGCCTGCCCTAAAAGAGGTCCTGA K*

AGGAAGTGCTAAACATGGAAAGGAACAA

CCGGTACCAGCCACTGCAACAACATGCC

AAAATGTAAAGACCATCAAGGCTAGGAA

GAAACTGCATCAACTAACGAGCAAAATAA

CCAGCTAACATCATAATGACAGGACCAA

ATACACACATAACAATATTAACTTTAAATG

TAAATGGGCTAAATGCTCCAATTAAAAGA

CACAGACTGGCAAGCTGGATAAAGAGTC

AAGACTCATCAGTGTGCTGTATTTTGGAA

ACCCATCTCACATGCAGAGACACACATA

GGCTCAAAATAAAGGGATGGAGGAAGAT

CTACCAAACAAATGGAAAACAAAAAAGG

CAGGGGTTGCAATCCTAGTCTCTGATAA

AACAGACTTTAAACCAACAAAGTTCAAAA

GAGAAAAAGAAGGCCATTACATAATGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10045561 5 144189072 AGATTATAGGATGCTACAAGGGCTTGTG A/G TGTGTAGGTCCTTATAAAACATGGAAAGA SEQ_0289

GAACATCCACCAAATCCAAGTTTGTATGG AGTTTAGATATTATCCTAAGATAAGATAA TCAGAGAAGCTTCACAAGAGAAGTTGCT AACCCTTTGAAAGATTCTAAACAGAGGAG TGAGATGAGACCAGAATTAGTTATGTAGA TAGCATAATTAAATTTGTGTGTATCATTCC GCAAGAGTTATGAAAGAATCTCGACAGG TGCTATGGGTGTATAAGGGTGAGAATTT TGATTCCAAGAGAGAGAAACGGAGAGAG GAAAGTAAATATGGAGATATTACAGAATA AGGGGGAGTAAGAGAGACTGGTTTTCAA TGTCCAAAAATGAATTATGTAATTAAAAAA GTACTGAAATACTTTTACTGTAAAGGGAC TAA I I I I IATGTTTATTTGTATACATTTATG TGTTGATCTCCAAGTGGGCGGGTGCATT GGATACATGTGCAATTTTATTGCATACAT GAGAAGGTGAGAGGGGTAGCAGGAGGC AGGCTGCATATTTGCCAAGTAAGAGCTTT CTGA CAGGGTATCCATCACCTGAATAACATACA TTATAACCATTAAATAATTTCTTATCATΠT CCCTCTTTCCACTTTCTCACCCCTTTGAG TGTCCATTATCTATCATTCCATTCTCTATG

TCCATGTGAACACA I I I I I I AGCATCCAC TTATGAGTGAGAACATGTGATATTTGTCT TTCTGTACCTGCCTTGTTTCACTTAATAC K* T rs10050736 144189912 TTTCTTATCATTTTCCCTCTTTCCACTTTC A/C TTCTTTGAAGGTTCCACTTGGTTGAATTA SEQ_0290 TCACCCCTTTGAGTGTCCATTATCTATCA TGGTTAACCAAGGTTCTAGCATTATATTT TTCCATTCTCTATGTCCATGTGAACACAT AGATTGCTGCATTGTCTCAAA I I I I I AAAT TΠTTAGCATCCACTTATGAGTGAGAACA CATTCCTATTC I I I I I I i I I I CTAGACATA TGTGATATTTGTCTTTCTGTACCTGCCTT CAGGA I I I I I I I I CAGATATTAAGACTCT GTTTCACTTAATACTTGC I I I I IAATGACT GTGTTTCTTACTACAAGACATGGAATGAA TGCTTCTTTCTCCTTTCTTCACCTACATCT ATAAGTTAGGAAATGAATTGTTTGTCTGC AAAATTAGAGTGTCATATTAATTTGAGAA TGC AGAGAAGACTTATGTTTGTCATTTTAGAA TGAAAAACTATAGCCAAGCTAGAGGAAA GAAGATTTTAATTAGAACTTGATAAATAAT GATCTGATAATTAGAGCTGTGTGAGAATC AAATAGGCAATCTCGGGAAGTAAGTCGC CACTCCTGGAAACATTTCTGCAGGGAAA AGATGATCACTAATAAAGGGATGTTGTG GAAGAGATGACTATGTTGCCAGGAGGTT GGACTAAATTGCCTCTAGAGTTTCTTCTG GTTCTCAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1432746 5 144193685 TAGCCCTTCTGGAAATTGCTACCAAACAG GfT CTTGCATTTTAAGTCTCATTTCTAGTAATA SEQ_0291

TGAAAGTTGGAACAATGGCTGAAACCCA TTTTACA I I I I I G I I I I I I I I CTCCTTCTGT

TTTGGCATTCTCAGAACACTGCACTGTG ATACTAAATTAGGCTTGTGTTATCTTTCA

CAGATTCACATTTACAAGTTACTTTAAATT CTATCCAGACCAAATTGTGGAAATCAATC AAAGCACACCTAATCTAACCCCTCGAGG AGCTCCCAATACTATGGGGACTGAAATAT GTGAATAGGCAAACTTCTCAAAGTATGAA AATTACTGTGATAAAATAAAGCATAGAGT TATTAAATGGATGTTAGGAAAAGCATATC CCCACCAGAACTCAAGAAACTTTTACTCA TGGTGGATGGTGAAGTAGGAGCAGGCAT ATCACACAGGCAGATCAGGAGCAAGAAA GAGGGGGAGGAGACACACACATTTCTAA ACAACCAGATCGCATTTGAATTCACTCAC TATCAGGTGAACAGCACTGAGCTATGAG GCATCCCCAGAAGCCAAGCAGATG K* rs10060915 144194024 CTTAAAATGCAAGACACAGTGCAGTGTTC C/T GTAGTCTCACTGAGATGGAATCTTTCTTG SEQ 0292 TGAGAATGCCAAATGGGTTTCAGCCATT ACAATCATCATGAAGTGGACATTTTGGTA GTTCCAACTTTCACTGTTTGGTAGCAATT TAATGAACATCATACACGACAACATTCTA TCCAGAAGGGCTATGTTGCAAAGGATTC AAAAGGGGATACAGTGACAAAATTTATAG TGAGGCCACATTTCATGGGTAATAGTACT TGTTA I I I I I I I CTCACTAACCCTAGATAA GTGTTTGATTTGTGGCATCTGCATTGGAG CAATCAGGGAAACTCTATCTAGTACAATT ACTGAAGAGGGATTTATGACTCATAATTT CATTAAAAATAACCCTTGGTATGAC GCCATTCATGGTCTATATATTTGCTTAAG GATGCATGAAAAATTTGGGTCTAAACTCT TGGTAAAAGAGAAAAAAAAGGTCAGTTGT ACAAATTATAGTTCCCCCAATAAAAAAAC ACACATAATGTTTAGAGGGAAGCACAGG

7 TlTTTT rs10213858 144197735 TGTGAAACTAAAATAACTATTTCTTTATTT C/T AAAAATAAGGAATAAGATΠTTAAAGGTC SEQ 0293 TAAGCTGTATCCTCACAATGCTGCAATCT TTATTCTCTTTCTTCGTTATCCTTTAGAAA GTTGCTTTCTTCCTAA I M I I I I CCAACAA GATACTCATAGAGGACAAAATAGAACTGT ATCACTTGAAGTCTTATTAATATTCATTAG GTGTACAAATACACAAATTAGTCTAATTT TATCTCAGAAATAAAACTTCAGAATATT T GAAATGAACGGAAAGAGCCTAGCAAAAG GAAGAGTCAACTACATTAAATTGTCCCCC AAAGTGTGAATGAGATACCGAAAAATTG CAAATTTCCATCAAGTAAAGTGA GCTGCCACAGCCAGCACTTTGCCATAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2163748 5 144199632 TCAGATATTGGGTTCAGGACTAACAGGT A/G TTAAAAGATGGTCAACCACATTAGTTGTT SEQ_0294

GAGCTGGAAATTAAGGATGGTTACAGGA AGGAAATGAAAATAAAATTACTCTGGGGT

AAAGGGGAGATATATAAAAGGAACCCCA ATTATTTCATGCTCAACTCATTGCTCCAC

CAATTCTGCAAGGGGGCCTATCATGGGT CTTCCACTCCCCTACACCATCAAAAATAT

TCTTGATTGGGTTTGCATGTGTAGTGCAA AAATAAATCAAGTCCAGCAATATCAGGTA

AGTGCCACAAAACTTAGCAGAGAATAGC TTGGTGAGGCTAGGGCAAATAAGATTCT

TGATTTTTGCTGGGAGAGGAACAGAGAT TATACACTGAGAATATGAAAAGTCATTTG

AGCAACAGGTATTTCACAGAAGAGGAAA TTACAACTACTGTGACATAGTTTGGGCAT

CACAGATGACTAAGATAAT TAACTAGTATATCTGACATAGTGATTCTA

CCACCAAGTAGACCTTAGAGAAGCTTTT

GCCCATGTGTCCCGGAGACATGTGCTTG

CATATTCACAGCAGCATTGTTTATAATTG

CTTATAATAGCTAAAAACAAAAAAAGTAA

TGCCTATCAACTGTAGAATAGACAAAATA

CAATΠTGTCAATACACAGAAATATTATAT

ACCAGTGAAAATTAATGAAATATGGCTTC

ATTCATAGATCTACAAGAATAAAACTCAA _W

AAATAAAAGTACATCAAAATGTTAGTAAA §;

CTACATACACTATTATATAAAGTTCAAAGT AGAAACAATGAATAATATAGTGATTAGGT A rs10070601 5 144229206 AGACGTTCACAAAGTCAGAAAAATTTGTA CfT GGCATTGGGAGGCTGCGGTAGGAGGAT SEQ_0295

GAACTGACCTAATATGAAAACAAAGAACA TGCTTGAGGCCAGGAGTTCAAGACCAGC

GA I I I I IATATTATTAAAGAAAACACTTTG CTAAGCAACATAGTGAGCCTCTGCCTCT

AAACTTAAAAAAAAATGTAACTGATTCAC ACAAAAAGCTTTAAAAAATAAAAAAAAAAT

ATAATCTTATTGAAACATTGGCAAATATTC AGCTGGGCAAAGTTGTGTGTACCCATAG

AGCCTACCTATACTATCCTTAATTAAAAT TCCCAGCTACTTGGGAAGCTGAGACAGG

GACTTATTTTACCACGATAAATTTAAATTT AGGATTGCTTGAGCTCAGGAGTTTGAGG

AAATTATTTCAAAATACTTC ATGGAATGAGCTATGGTCATGCCACTAC

GTGACAGACAGCCTGACAGAGCGAGTTG

CTGTCTCAAAATAAATAAATAAATAAAATC

CAAACACTTCCTGAAAACAGGTAATTTTA

TTTTAGCAAGTAAAATGTTACTTCTATTAT

GATATTACTATCTAATAATCTATGTGCCC

TGAACAGCACTTCAAATGCAAATAACTAT

TCTGTCGATGGCTACACCTGTAAAATAGA

CCAAATGATATTACATTAACAGTTTATCAA

CCTGCCATTATTAATTTTAGAAT rs17454163 5 144234232 TCAATAACCGGTTGCTGCATAATAATCTG A/G GCCCAGAGCTGATCATTTCTACACTGCTT SEQ_0296

AATTTGGCTCCAAGTTATTGGCCCAGATG TGACTAAGTCCTCTTCTAATCATATGTAA

AGCAGACCATAGCTAATCCTCCATTTCTC TAACAATTTCTATTAATCAGTTTTCTAGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 13357903 5 144235338 TATTTCATAAATTTCATAAAAAAGCAATGT C/T AGGGAGAAACTACAGTGGTGTGGATTCA SEQ_0297

AGGATAAAGTAAGGGACTAAGGCTAGAG GGTAAAAACTATAAAGTTGGCAAGAAATT GAAGGCAATGGAGTACTTTAATTAAGGT ACTCAACTCGGGTTATATTTTGAAAGTAG GATCAGGAGAGCCTTCCTTAAAGAGATG AGCCAAAGAGACTTATGAATGGATTGAAT ATACTTGACTTGAGATCTGGAGCATTACA GTGAGAGCACAGACAGAAATAAGCAATG TAGAAGCAGTCATTCAGAGCTCTGTGGC CAATTCAAAGGATATTTCCCTGAGCAGAG AAGAACATTCCAGAAAGAAGGATCCACA GAGGTAGATGTGTAGCTAGTTGAGCTAT AATATAAAGACCCTAAAAAAGTGAAAATG TTACTGATATTGGAAAAACTGGAGGAGG ACCTTAGTGTATTTGAAGGGCAGAGACA AGAAGGTTTAAAGAGCACTATTGGGAGA AGGCTCATATGGGTGAAGCAAAAAGATC AATCAAGAATCCAGCTCAACATCCTCATC TATGGGGAAAGTAGGATGTAGTTGTTGA AACCATAAAGGGAGAGATAAGTAGATTG ATAGACAAGAACCTATTATCTAGGGTTTC TAGCCATTGGAGCCTAGTGTTTAAAGAA CTAGCTTACGGTAAGAAGTCTAGACTTTT GTCTGCATTGGAGACAGAGATTTGGGGC AGTTTTAAGAGGAAGTCATTGGAAACTTT CATCAATATTATAAATAAAATTCATAACAA TAAGCAGAAAATGAAAAGCTCAGGTATAA GAACATGGCTGAAGGCAATTCTCAGCTC GCTTTAAAAATATCTTTCTAGTGGAGAAC AGATCCCTTTAGTTCAAGAAATCAATGAG AGGCTGTAAGAAATCAAGCATTAGGAGG GAAAGAGAATGTCTCATTCCAGTTTCCAC K> TAGATACTTCAGTCC AAGGAGAATCCTAGG

ΓS13167122 144237999 TTATATCTTCTCTATACCTGTTACTACGCT AH^" TTTTACTTATCTAAC I I I I I CCCCCTGGG SEQ_0298 TTCTGGTTCTTACTTTCTGATGATTATTCA ATTAGTTGTTTTCCTCATATTGCCTAATTG GTAGAACCTCTGTTTAGAAAAAAAAAATG CACGTTATATCCTGCTCCAATTTTCATATT CCTCCTTATCGTTGTAGTATGCTAA I I 1 I I TCACAATTACTTTATCCGAGGGGAAAAAA CATGGAAAGCATATTATTTAAAAGAATAC GACTCCAGTATTTTATTTCCCCTAATACA ATTTATCCTCCAAATAATTCTTTATAATTA GAGTTTTAATTTCCTCAATTTCCAATCTTA ATTGTTTTGTCTGTAAGCCCTA ATATTTGTCTTTTCCTTCATAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs9324972 5 144240672 GGATGGCATCAGCAAGCTCCCTTCCCAT GΠΓ GGGGGAAAAGACAGATGTACAGATAAAT SEQ_

CTAGCTTCCTATTGAGTTTGATCACAGTG AAATATTTACACAAGATGGCAAAGTCTTC GGCATTGGCTGTGTTCAAGAGAGAAGGA AAGGTTTGAGTATCCACAGAGACCCTAG GAATAAAATAAAAGTTGCCATTCCCTAGG TAACTCCCAGCATAAGCTGTAGCAATGAT TCCTTTATAGCAGAGTTCTTTTAGTTTGG AATGATTTTTGTATCATCGCCTGGGTCAG CTTGTCTAAAGTTGCAAATTATCAAAGTC ACCCCTGTTATCTGTCACCTGCACAACAA ACAACTCCTAAGGGATAACCTCTCAGCT CAAAACTGCCTCCTTGTTACTCTCTCTGT CTTCTCATTCTCGGGGTTCCATTATACTT TGCCCATCTGGTGAAAAGCACTATTCTGT CTTCTTGCCCTTTCAGAACTAGGGATGGT TTACATCATGCAGTGATGTTCCT TATTGTTTCCAGATGTTACTAGTCCGAAG AAACTGCCCTGTCATTTGTAGTTACCTAA TATCCTACCAATAGTAGACATTGTCTTAA ATTCCTCAAATTATCCCCCTGTGGTTTGA TTA^"I I I I I CTTCAACTGCTTGAACAGCAG GCTAAAGAGAGATAATTGGAAAGGCAAT TTTAATGCTACAATCTTGGTCCATAGATG GTTCAGATG I I I I I CTGTCCTCCTGAAAT K* TCATTTTTTTT rs 10040705 5 144241285 ACCCTATCCACAAATCAGTTCTATGTTGA G/T CAAGAAC I I I I I I I AATTTAAAAGTTCAAA SEQ 0300

TTAAAGACCAAAGTATACAAATCAACTTT GTCTGGTAGAAGACATGGACAATACAAA AAAA I I I I I AGGGAAAAATCTGGGAAATC TAACTCACAGAAGAGCAAAATCCAGAATA TAGGAAATATGTGTGACTTCTAGTAGGAA AAAAGAACCCCAACATGTTGATAAGAAAA ATGGCTTTAAAATAAGACACAATGAGTGC ACATAATAGCCTAATTAAAAGAAATGACA AAATGATAAGGACAATATTTATGTATGTA AATGTAATAGCAAAAGTGTAGAGGAGGG TTTGAATATTATGAATAAAAAGTTTA AAAAACTTGAATACCAAATGAACCTAAAA ATTGTGTTTCTTCTCACTAGTAATACATG AAATGGTATTTAAATGTAATTCAATTCTAA TGCATGCCAATCAGGTTTACAAACATGTC AAAGTTTGATAATGTCAATTGCTGGAGTA TGTGGAATAAGAGAAACCCTTATAAATTA GTGTACCTGCTTTGGAGAGCAATTTAGTA ATACCTAGTTAAGTTGAAGAAGTGAAATA I I I I I GTCAATAACTAGGATGGTTGAAAT GTTCATTCCCATGATTCAAGTTGTCAGTA TATGCTCTAGAGAAAGTCCTGCACATTTC CACGTGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7712842 144247299 ATAGTTGCAGTCATTCTGCAATGATGCAT Cπ AAATCTTCAAGAATATGTA I I I I IAATGGT SEQ_0301 GTCAATGGCATCAGTGCATTTCTGCCAG GTTCTTCTTTGGAAGCATTTTAGTTATAC TATATAAATCTCTACCCATCTCTGCACCA AAAATGGTTTCACTGAACTTATGAATTAA TGTGGAGGTTTAAACATTTCATGAAATGA GAGCCCAATAGATTGTTGGTTACTTTGAA TACATTGCCATGAATCTTACTTATCTTCTC TTTATGAGTTCTCTGTTGAACTTTAATTTG ATATTTATACTGTCATAGTCTCTAAATAAT AAGGAAGCCAGCTACACAAGTCACATCA ATG I I I I IACTCTACTTCACAGATA ATTTTCAAAGTCTCATTACTGGTAT rs13436784 144256173 AGATGTAAATTTGTACAGCCAGTATGGAG C/G CAAAAAATGTTAGAAAGGATGAATAACAG SEQ_0302 AAGAGGAGTTTGGAGGTTCCTCAAAACA CTACTATTCAATAGCACTACAGAGTGACT CTAAAAATAGAGCTACCATATGATTCAGC ATATTCAATAATTGGATTGTTACTCAAAA AATTCCACTGCTGGGTATATACCCCAAAG GAGAAATGCTTGAGAGGATGGATTCCCC AAAGAAAATAAGTATATCGAAGAGATATC ATTCCTCATGATTTGCTTATTCAACATGG TGCACTCCTATGTTTGTTGAAGCCCTGTT CATGCCTATATCAAACACCTCATTTACCC TACAATAGCTAAGATTTGAAAACAACCTA CATAAATATATACCCTACTACGTACCCAC AGTGTCCATTAACAGATGAAAGGAGAAA AAAAATTAAAAAAAATTAAAAAATTATAAA GAAAATATGGTACAAATACACAGTGGAGT AAGAAAGTGTTGAGCCATTGTCCATGGT K* ATTATTCAGCCACAAAAAAGAATGAGATT ACTGAATGTATAATATAGCTACAGAATAG CAGTCATTTGCAACAACATTGATGGAATG ATGAGAACACTGTTGTTTACTTGACTGCT GGAGCTCATTGTGTTAAGTGAAGTAAGC GAACTAAATTTAATAGGACTTTCTAAGTA CAGGCACAGCAAGACAATCTTTGTGTCTT ATTAACTGGATGCCAAAAATGCAAAAGTG CTCACTTATTTGTGGGATCTAAAACTCAA AACACGGCACAGTCATGGTTTTCAAAAA ACAATTGAATTCATGGACATAGAGAGTAG GTTCACAATCATGGTGAAAAAACTGCCCT AAGGATGATTACCAGAGGCTAAGGAGGA T CACTGTGGGGCTGGGGGAAGGAGAGGA TGGCTAATGGGTA rs 13355677 144263062 CCTTTATTGCTTGTCAACGTTATAAAAAT A/G AATGCATAGCAATTTACTACAGATAATCG SEQ_0303 GTGTGTGTGTCCGCGTCTGTGTACACTT ATCATCATTTCAGAGTCTTTTCAAAAGGA ACTTGTCCTTTACCCTAAAACCAAGGAGG TTGGTTTGACGACATTTTCCACTGAGATT GAGTCTAAAGCAAGAATCATATCCTCAGA CATATGACCTTTTCCTACAATAAGGTTGA ATTTAAATTTAAATACCATTGTAAAGTAAT TCAAACTCCCAGCAAACCATGTTGTTCTA TTTAAGGGGAAAATTCAATCACATCTTTA CAACAGAAGACAGGTTACAAGCTAAAGA TAACATGGCAAATACACTAAGATAAT AATTAAAGCAGATTTATTTAATTTGTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 11743254 5 144265646 ACTAATTGATCCTGCTTGAAGAATGTACT A/G GCTTCCAGGAAAAAGGAGCAGGCAGCCT SEQ_0304 rci 1 1 1 1 1 1 1 1 1 1 1 GACAAACTGTTCTT TTGCTGGTGATACCCAGGCAAATAGGGT

TATTGGGTGATCTGATTGCCCAGTCTGG CTGGAGTGGACCCTCAGAAAACTCCAGC

ATTAGAGTCCCATTCCTGTGTCTGGGAA AGACCTGGAGAAGAGGGGCCTGACTGTT

GTAAGGATGGGGATTTATAGCCTTATAAG GGAAGGAAAACTAACAAACAGCAATAGC

TATCACATGTAAAAGAAAGGCAGCAGCC ATCAACATCAACAAAAAGGACGACCACG

CCAGTCAGGGTCTTATGGCTAAAACTCC TAAAAACTCCATCCGAAGGTCACCAACA

CATCTCTCTGGGACAGAGCACCCAGGGT GCAAAGGCCAAAGGTAGATAAATCCATG

AAGAGGTGGCTGTAGGTGGAGCTTTAGC AAGATGAGGAAAAACCAGTGCAAAAAGT

ATACTTAAGCGTTCCTGCCTGCCAGCTCT CTGAAAATTTCAAAACCAGAATGCCTCTT

GAAGAGAACAGCGGACCTCCCAGCACA CTCCTCCAAAAGATCACAACTCCTAGCC

GTGCTCGAGCTCTGCTAAGGGACACACT CACAAGGGAACAAAACTGAACAGAGAAT

GCTTTCTCAAGTGGGTCCCTGATCCCCG GAGTTTGACGAATTGGCAGAAGTAGGCT

TGCCTCCTGATGGGGAGATACATCCCAA TCAGAAGGTGGGTAATAACAAACTCCTC

CAGGGGTCGACAGACACCTCATACAGGA CAAGCTAAAGGAGCATGTTCTAACCCAAT

GAGCTCCAACTGACATCTGGTAGGTGCT GCAAAGAAGCTAAGAACCTTGTTAAAAG

CTTCTGGGACAA GTTAGAGGAATTGCTAACTAAAATAACCA K*

GTTTAGAGAAGAACATAAATG O rs 10067954 144272557 AAAAACAAACAAAAATTTCCAGATCTTAT GfT GAAATCAATATGTTGAAGAAATGTCTGCA SEQ 0305 CATCAACATCCCCTTGGAAGAATCAAATA CTCCCATGCTTACTATTGAGTTATTCATA AAGATAAACACTATGAAACAATGTCAAAA ATAGCCAAGACATGGAATCAATCTAAGTG TAAGACATACAAGGCTGAGGCAGGAGAA TCTATTAACAGATGAGTGAATAAACAATA CGGCGTGAACCCGGGAGGTGGAGCTTG TGAGTTATATATGCACAGTGGATTACAAT CAGTGAGCTGAGATCACGCCACTGCACT GTAGCCTTAAAAATCAAGGAAATCCTGTT CCAGTCTGGGTGACAGAGCGAGACCCC ATTTGTGACAACATGGATGAACCTGGAG ATCTCAAAAAAAAAAAAAAAATGACATAC AACATTATGTTAAATGAAATAAGGCAGAC AAATGGCCAACAGGTATATGAAAAAAAAT ACAGAAAGGCAAATAATATACGATCTCAC GTTCAACATTACTAATCATCCATGAAATG TTATATGTGGATTCCAAAGAAATCTAACC CAATTTAAAATCACAATTAGAATGACTAAT CATAGAAGCAGAGAGGAGAATGGTAGAT ATCAAAAAGACAAAACATAACAAATATTG ACAAATGGCTGTGGAAAAAGTGTGGAGA AAATTGTGGAGAAAAGGGAACTCTGGTA TGTTTGTCAAAGGATACTAAATTTCAGTT TACCTTGTTGGTGGGAATATAAATTAGTA AGACAGAAGGAATAAATTCAAGAGATGTA TACTCATTATGAAAAACATTATGGAAGCT AGACATGATGATCATGGTCAATACAATTT CCTCAAAAGCTTAAAAACAGACCTACCAT AGTGGATACTTGAAAATCACTAAAAGTAA ATGATACAGCACTCCCACTTCTGGGTATA ATATTATATGTTCTCACCACAAAATGAAAT TCACCAAAGGAGA AAATATGTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10070114 5 144273603 AGGTACCCCTAAGATTCCAGGTAGCAAT GfT AGTACACACTCAAAATATTCAAGTATTATT SEQ_0306

AAGAGATAAACCACTTGATCAGGAAGTTA AAGATTCTAAAGATAAAGCCCAAGGGGC

CTGCTGGGACAAATAATCTCTCACCAATT CAAGCATGACACCTTGATTAATGAAACCA

CTCTGTTCTTGAGTCCCTGTATGCTGAGA TCAAAACTCTACTGAAGAAGGAGATATAA

AGCAGGCAGCTGTGTGTTTAAAAGCATC TCTCTTGTAAGAATGTTAGAGTACATTAG

TGCACACCCATCAGACAGACATGGATTT CAGAAGCGTGGCTACTCAAAGCTAGAGA

AAATTCCACTACCAGCACTTAAATACTGG GGCAAGGAATGACAAATGTCCCCTAGAG

CTCTCTGGTCTTGAGCTATTCATTTCAAT TTGCCAATGCACAGAATTACAACTCCATT TATAAAGTGGGGATAATAATGACATCTAT TTTATTGGGTTGTTGTGTGACACAAAGGC TTACATTAATGTCAAATCCG rs11167873 144276327 TATTATAATGAGAAAAACTGGCAACAAAC A/G CTGTGCTA I I I I I I CTTTTAATGGATAATA SEQ_0307 AAAATAAAAAAAATATTTACAGGTAAAGG GCTGAACCAGTGTAGGTAGAGTATCATG CATATGCCAGGTAAGGTCTAGAAAAGAG TATGTGCATATCCACATTATCCCAACTGC TTTAGGAGGAGATTGGGCTTTAGACAATA CTCTACTCTTTGCATTACTACTGGGAAAG AGTGAATTTATAAGATTATGGTTCATATAA AACCACAGACTGAGAAAATGACAACACT K* AAATGTATAAAGTGTTTAACTTACACTTTC CATTGTCCCGGTGACTTCTGTAAATTCTG ATGCTAAAGAAAGCCTCTGAGTTAC GTGGATTGAGACAACTCAGGCAGCCCA rs 10044798 144277067 AGTGAGCCAGAAAACTTATGTGACTATG CfT TAGATC I I I I I I AAAAATCCTTATCAGAAC SEQ_0308 GAGGCCAAGCAAATGATGGAAATAAGTG AATCAAAAGATATTCATGGGATGCCAGTT AACCTATTAATTGGGAGTGGTAAGAAGT TGACACACTTGTCCAGAATTTTCAACTTT GGAGAAGCATGTCTCATTGATAGATGCA ACAAAAGTAATATAGGGCAATGGTTACAA ATGACTGCGAGTΠTAGACAACTGTGTTC ACCCAAACTTTTAATACAGTCTGGTTCAA AAGTAGAAATGTAACCTAAAGATGTTAAG ATTCCCTCTCTATTGCCTATTAACTGAAT ATATCCTGA I I I I I I I CAAAG I I I I IAATG GATCCTGGGAAGTTACTAAAATTTCCTGA TCCTCAATTAACTCAATTGTGAAAAAAAT ATAATGCCTAACTTTTGGAATTGTTGTAA AAATTGCAACAATATATTTAAAGTTCATAA TGGTGATGATGACTGTTAGAACAAAAGTA ACTCCAAAATTCTTTATGTCTTTGATTCCT AGAGTCCTATCACAATCACATTTTCACCA TGTTAGGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs6894954 5 144294556 CTTCTATACTTATTTTCATGTTTATATAAC A/G GAGACATTGCAAGTGATAGCACAGAAAT SEQ_0309

AATATACAAAATTCATATTAACACACTCAT GAAAGGGATCATAAAAAAGTGCAATGAG

ACACATTAATAGTTAAGAAAAATTTGTTTG CAATTATACACCAACAAATTGGATAACTC

CTTCACTATATAAAGATAACCCTACTACA GAAAGACATGGATAAATTCCTAGGAACAT

TATACTTTCCTGTACCTTAGTC I I I I I GCC ATAATCTACCAAGTCTGAATCATGAGGAA

CTTAAAAATACATTGTGAAAATGTCTTTAA ATGGAAAATCTGAACAGACCAATAATGAG

AACTATATAGTGTGCTAACTGGCATCAAC GGAAAAGATGGAATAGTAAACAAAAATCT

AAAATGGCAGAATGGGAATTCTTAGTGCT TCCAACAAAGAAACGCTGAGGACAAGAT

TGACCCCTCACAGAACCATCAATCTGAA GACTTCACAAGTGAATTCTACGATCTTTC

CAACCATCCATTAATAAAAATCCCTGCAT TCAAATTCTTCTAAAAAGTTAAAAAGAAG

GGGACCTAAGGAATCCAGATGAGAGATT GGAACACTACAAAAGTCACTTTATGAGGT

ACAGCACCTGAGTGTAGGGTGAAAATAA CAGCATTACTCTAATACCAAAGCCAAACA

GAAAGGATGACACACTGAAGAGAGTGGG AGGACATTATAAGAAAAGCAAATTAAAGG

AAGGATTGTTTCACACTACCCATATCACC TAATATCCCTGATGAATACAGATGCAGAA

CTCCCTCCATGTTGGGAAAGGAGATTGA ATCATCAACAAAGTGCTATCAAATCAAAC

AGTCATCATTCAACTATGCCACAGACCCC TCAATAGCACATCAAAATGATAACACTCA

AGCACCAGGCCCATTCAGTGAATCCTGG TAATCAAATTGTACGTATCTCTGGAATAC K.

TGTGAAGCTGGTTCCAGTGGCCCCAGGA AATGACTTTTCAACATGGACAAGTCAATG ^

TTTGGGTCTTTCCCAGTACCAGGGCAGC AATGTGATAGACTACATTAACAGGGTAAA

CCTGCAACAGCACCAGTCTACTGCCCAC GGAAAAAGCTATATGATCATCTCAACAGA

AGCCCCAAGCTCCAGACTAGCTCCTATG TGCAGAAAAACATTTGACAAATTCAACAT

GACCAAGATTCTGTGTTGTTCTCAGAAGA CCTTTCATGACAAAAACTCTCAACAAATT

CCCAGACTCCAGAGGTTCAACTGCAGAC GGAGAAGAAGTGTATCTCAACATAATAAA

TCAGGCTTAAGACTTACCCCAGTGTCAG GGGCATGTATGATAGCCCCACAGTTCAC

ATAGGTCCTCACAGTCCCAGGCACCAGA ATACTTAATCATAAATAGCTGAAACATTTT

CATTCCCACAGGATCCAGGGACCAGGCC ACTGTAAGATTAGGAGTAAGAAAAGGAT

TGCCCTAGTGGACCATGATGTCTGCCCA GCCTGCTCTTGTCATGTCTATTCAGCATA

AACCGTACAGACTGAGAACACAGCCCCC GTATTAGAAGTCCTAGCAAGAATAATTAG

CATCCCCCACCGCCCCCAAAAGACTCAG GCAATAAAAAGAAATAAAAGTTACCTGAG

GTTGAAGACCAGCTTCTGTGTACCCAGG TCAGAGAAGAAATAAAATAGTCTCTGTAT

CTTCAGCCTTGCCTCTATGAACATAGGCT GCAGATGATGTGATTTTATATGTAGAGAA

CCAGGCCCCACCACATGTATCCAGGCAG AACACTTAAGATGCAACTAAAATTTGTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6861229 5 144296195 CTTCTATACTTATTTTCATGTTTATATAAC A/C TAGCCAAATAAATCTTGACCAAAAGAACA SEQ_0310

AATATACAAAATTCATATTAACACACTCAT ATGCTAGAGGCATTACACTACCTGAATTC

ACACATTAATAGTTAAGAAAAATTTGTTTG AAAACACATTTCCAATCTGTAGAACTCAA

CTTCACTATATAAAGATAACCCTACTACA AGAATATGATATTGGCATAAAAATAGACA

TATACTTTCCTGTACCTTAGTC I I I I I GCC TATAGGACAATGGGACAAAATTGCCCAG

CTTAAAAATACATTGTGAAAATGTCTTTAA AAATAAAACCACTTATATTTGGCAAACGT

AACTATATAGTGTGCTAACTGGCATCAAC TCCAGGAACATACAATGAGGAAAGGATT

AAAATGGCAGAATGGGAATTCTTAGTGCT ATCTCTTCAATAAATGATGCTGAGGAAAC

TGACCCCTCACAGAACCATCAATCTGAA TGGATATCTACATGTAAAAGAAAGGAACT

CAACCATCCATTAATAAAAATCCCTGCAT GGACAATAATCTCATACCATACACAAAAA

GGGACCTAAGGAATCCAGATGAGAGATT AAATCAACCCAAAATGGATTGAAGAGTTA

ACAGCACCTGAGTGTAGGGTGAAAATAA AACGTAAGACCTAAAACTACTAGAAGAAA

GAAAGGATGACACACTGAAGAGAGTGGG ACACAGAGAATAAATTGTTGACTTTGATT

AAGGATTGTTTCACACTACCCATATCACC TGGGCAATGATTTGTTAAAATATTACACC

CTCCCTCCATGTTGGGAAAGGAGATTGA AAAAGCACAGGCAACAATAGCAAAAATAA

AGTCATCATTCAACTATGCCACAGACCCC GCAATGGGATTGTATCAACCTGTAAAGCT

AGCACCAGGCCCATTCAGTGAATCCTGG GTTGTACAGCAAAGGAAACAATCAACAG ^

TGTGAAGCTGGTTCCAGTGGCCCCAGGA ATTGAAAAGACAAGCTATGAAATGGGAG C3

TTTGGGTCTTTCCCAGTACCAGGGCAGC AAMTAΓΠTCAAACCATGTATCTAGTAAA

CCTGCAACAGCACCAGTCTACTGCCCAC GAGTTAAAATCCAAAATATGTAGGCAACC

AGCCCCAAGCTCCAGACTAGCTCCTATG CACACAACTCAATAACTAGAAAATAAGCA

GACCAAGATTCTGTGTTGTTCTCAGAAGA ACCCAATTAAAAATGGGTAAAGAACCTCA

CCCAGACTCCAGAGGTTCAACTGCAGAC ACAGGCATTTCTCAAAAGAAGAAATACAT

TCAGGCTTAAGACTTACCCCAGTGTCAG TTTCCAATAGGTATTTTAAAAAATGCTCAA

ATAGGTCCTCACAGTCCCAGGCACCAGA CATCACTAATTATGCTGGAAATACAAATC

CATTCCCACAGGATCCAGGGACCAGGCC AAAATCACAATGAGGTGTCATCTTATACT

TGCCCTAGTGGACCATGATGTCTGCCCA TGCTAGGATGGCTATTATCAAAGTTATTA

AACCGTACAGACTGAGAACACAGCCCCC AGGATAAATATTTATAAGAAGAAAAGGAA

CATCCCCCACCGCCCCCAAAAGACTCAG ATCCTTGTACACTGCTGTTAGGAATGTAA

GTTGAAGACCAGCTTCTGTGTACCCAGG ATTAATACAGCCATTATAGAAAACAGTTT

CTTCAGCCTTGCCTCTATGAACATAGGCT ATAGTTTCCTCAGAAAATTAAAAATAGAA

CCAGGCCCCACCACATGTATCCAGGCAG GTTTCATATGCTCTAACTATCCCACTTCT rs9324973 5 144304626 TAAATAAACTAAAAGGTGTCTCACAAAGA C/T ACCATATGGATCTTCAGAATATTTACAGT SEQ_0311

GTATTATCAACA I I I I I ATTTTATCACATA GTATGTCTAGAATAATCTGATTTAAAGTA

AATGTGTAA I I I I I I GAAGCTGCAATTAC TAGTCTGATGGTCACACTTGAAAGTCATG

TGTTGCTGTTAC I I I I IAAATAATATTTTG TTGGAAAACCTAGATGGCACCCAAAAGC

AAGGCAAAACAGGAAGAACAAAATTCAT AATAGATATCCTTCTGCCAGAACAGCTAA

GTAAATAAAATTAAGTTGTTCTTTCCTATG AACTGAGCCTCAGAGAGACACCCTCGTA

TCCTTAAATACATTTCATGTATGT ATGGCTGACAGGAAGATACAGGCAACAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10476865 5 144305920 ATTTAGAGCTCCCCATTTGAAAACCAGAG A/T ATCAGGAAACTCTGGCAATTGATAATCAA SEQ_0312

ATCAATGGCTGCAATGTGAATCTGCTGAA GATGATATTAAAATAGCAGTAGAGCCACC AGAATAACAAAACAGCAAGCTAAACATCT ACTTATTGAGTTCGTATGATGCATCAAGT GGACTAATTTTCAGAAGTCATAAAATGGA ATTTATATTTATTTATCAAAATTATTTATAA AACATTACCAGAAAATATGATAGAGCTTG ATGCCTACTATATGTGAGGCACTΠTCCT GCAGGTAAAGAGAATGTCAAAAAAATCT CGGTGTAGAAATGCAGCTAGAAACAAAG GAAAGGGAGAAAATAGAATAGGAAAAA ATAAACAAAGTACCTGACTTCATAGAGCT TATATGCCAGTGAGGAAAATTTCTAATTA

TTTC rs 10477261 144306068 G GTAAAG AG AATGTC AAAAAAATCTG AAA C/T GGTGTAGAAATGCAGCTAGAAACAAAGA SEQ_0313 GGGAGAAAATAGAATAGGAAAAAAATCA TAAACAAAGTACCTGACTTCATAGAGCTT GGAAACTCTGGCAATTGATAATCAAGATG ATATGCCAGTGAGGAAAATTTCTAATTAT ATATTAAAATAGCAGTAGAGCCACCACTT TTCCAGTACTTATGACAGTGCTGCAAAGT ATTGAGTTCGTATGATGCATCAAGTATTT AGGAATTGGCAACCCCAATΠTATAGAAA ATATTTATTTATCAAAATTATTTATAAATG TTGAAGACTAAAGAAAGTTAATTAACTAT CCTACTATATGTGAGGCACTTTTCCT AACTCATAATTGGCTGCCAACTTGCCG

K> rs 17613806 144310140 TGTTGGCGGTTTTGTGGGA I I I I I I I I I C C/T ACCATCCTCTATGCAACTTCACCCCAGAT SEQJ3314 4- ACACCACTCTGCAGTTGAGCTTGTGTTCT ATGAACTTGTTCGTGTTGTTTCCCCATCT AAAATAGCTGTTCATGTCTCCAAACTTCA TGAAATGTTCCTTGTCCTCCTCCATACAC TTTATGCTAATCT ACCCTATCCCATC rs 1476736 144313655 TTGTGTTAC I I I I I I CAAATGGCATTTAAT C/T ACTGTCTGGTGTGCAGCATTTAATGTCCA SEQ_0315 GTCTAGTGTATCATTTTAGCTTCACAATG GTAGCTAAGAGGAAGACAGAGAAGTTAG ACAGTATAATATTGTTTAAGAGCTTTTGC AGGAAAAGAAGATGGAAGATACCAGCTA TCTGAAGCTAGACTGCCTTGAGTTCAAAT CTACTACTAGATTCGAGGATTG I I I I IAC GCTGACTCTGAACATGAACCTCTATAAGC AAATTTTTGCTGTAAAGGGCCAGAGAGTA TTCAATTTTCTCAGCTATGAAGTTTGAGC AATATGTTCGGTTTTGTAGGATATATATT TAATAAGAGGATTTACTTCTTAAGGATGT CTGTTGCAAATATTCAAATCTGTCATTATA TGATGATGAAAATCAATGAAGGACATGCA GCCAGAAAGCAACAATAGATACACATAC GAGAGTTTAAATAACTATAAAAAGATATT ATGAATGGGTGTAGCTGCACCCCCAATA GGCTCTGGTTGCTGATGCAATCAGGAAA AGATTTTATTTACAATAACATGAATTGGC CAAAACACATAGTCAGCATCTAGAATTCA CTAGATTTGTCTCTTGCCATATGCCATAG CTCTATCAACCATGCATACTGCCTGTCCT TTTGGCATCTGGATCACAGAATGAGAACT ATCCCAGGGGTTTGTGAGGATTTAGCAA TGAAAACAGTCTTTTGTTGAAGTTCAGTA AACTTAGCC TTCTTTGCAGCTTCTCCCAGCTGTCACCC TCTGGCCTATTTTATTACTGGGAACAATG AGGGAATGAGACTATATAACCCCTTATGC TGTTTTCAGAACTGATGGTCTAAGAGTCT ATGGTATCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11167886 5 144364033 AATGAGACCATAGAGCTATTAAACTGGG AAT ATGTCTATCCTATGCTTGCCCCACCATTG SEQ_0316

AACATCTATTATTAAGACAAGAGCAGAAG I I I I I GGAAGCACGTAACTTGTTTGATTT AACTTCAAAGGAAATTCAGAGATCATCAA CACAGGMTTTTGTCTCAATAATTTGCAC GGCTGCCACTCCTACCACAGGCCAAAAG CTTGAGTCTCATTAATAGTTGATTTAGAT TGAATGGGCCTGCAGGGCAGAGCTCTCC GATATTTTGATGAGACACTTGTGTTTAGA CACCTCCATTTCAAAGAGTGGGACCCAT CTTTAGAGTTGATGCTATGAGTTAAGAAT GCCTAGTGGAGCTATGGGGGCAGGGCT TTGGGAATTGTTGGGGTAAAATTAGTGTC GCCTGTTGAAGTACTAGGTACATGACCC TTTTGCATGTAAGAAAGGTGTGAATTTCG CCCACCACTTGTGAAAGAGAAGAAAGGC AGGAGCTGAGGATAGAGTATTATGGACT ATAATGGAATCACCACAGAAAGCCAAAG GAATGTTCTTGCAAATTCATATGTTGGCA TTGAACATCACCCTGCCAAGCTGTGGAG TCCTAACACTCCATGTGATGGTATTAGGA GTGATATTCCTATATCTGTGGGTCTGGAA AGGTATAGCTTTGAGGAGGTAATTTAGGT GGTGGAAACTCCTCCACCCAAGTTGGTC GATGAAGATGGAAACTTCATGAATGAAAT TGTAAAGCAAAACTTCAAGCGGAAGAAG TAGTGCCCTAATAATAGAAACTCCGAGA ATTATTCTTGATCCTTAAAGTTTCGGGGG GTTACCTAGTCTTCTTCAATCATGTGAAG GCTTGTCTTGCTAAGTTTTGAACTTGCTT ATGCAATAAGAACAGGGCAGTCTGCAAC GGTATTATTCATTCCTTCC I I I I I I CTTAT CCAGAAGAGGATTATATTAGAGTTTTCCG K* TTATCTCTTTGGAATGGA GAGAAACAAA rs11744715 144373085 AATATTATTTACAATAGCCAAGCTATGGA A/G TGATGTATGCATATATCAACAGGTTGTAT SEQ_0317 TTCAACCTAAGCGTCCACTGACAGATGA ACCATAAATATACACAAATTTTATTCATCA ATGGATGAAGAAAATCTGATATATTCATA ATTAAAAGAAAGGAAAGAATTTAATGTAT GAATGGAATACTATTCAGCATTAAAAAAT ACAATTTCAAAA I I I I I CTGTAAATAACCA AATAAAATCTCGTCATTTGCAAAAACGTG TTTTCACACAAAAAAGTAGTACTTTATAAA GAGGAACCTGGAGAACATCATGCCAAGT CTTCTTTGTAAACTACTTTTATATATTGAG GAAACAAGACTGATACAAAAAGACAAATA CCTTTCTATTCATTATA I I I I I IACATCAT CTGCATTATCTCTTATGTGAAGAATCTAA AATTTTAATAGCTGCAAGTTATTACATCAT AAAACTTGAACTCATAGAATCAGAGGGTA ATAGATGAAACTTGCCAGTTTTAAACTCA GAATGGTGGTTATACCAGTGGTTAGGAG TGTGCTGTAATTGGATAGGCAATTGTTTC GAAGGAGGAGTAGAGAGATGAGAGTCAA TAAGAAGTGGCTTCTAAAATCCAAATAAA AGAACACAAAATTTCAATAGACAGGAGAT AGTTAATATTTTCCAAGATTAAACCTTTCA ATGAACATAAGAAATATATTGTATAACAT AAGTTTTGGAAGGAATTTATTAAAGTTAT GGTGACTATAGTCAATAACAATGTATTGT AGTTCTACAAGTAAAATTGCTGGTGCAAA ATACTTGAAAATTACTAAGAGTAGATTTTA TGGTGTGCAAA I I I I I AACATACAGTGGG AATGTCCTCATAACAAAAAATATGTGTAT ATATTACCAAACCACTACAGCCAAGAATA AAGGCTATTGATATGTTAATTAGCTTTATT CTTAGAGAATCAGCACTTCCCCCCTACT TAGCTGTCT G

Supplementary Table 3

SNP Chr Position 5¹ Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs740475 5 144377800 CTGTAGCAGGAAAAATAAAGCTACACAG A/G TAACTATTTCTCTTTATGATCTTAGCATTT SEQ_0318

TTGGAGAAATCTCTTAAAAATACCTTTCT AACAAAGTAAACATTAAGGCAACTAAAGG GTATTTTATAAATTTTCTGTAATATGTAGC TTGATGAATTTGCCAGGGCTAAGTCTCCA ACTTTTGGTTGAAAGTATGTTTTAA I I I 1 1 ACTAAAGA I I I I I CATTACTCAGATTACTT AAAGAAATAAAAGAGATTGCAATTGGATG ACAAAAAATATTGTATTCATTCAAATGATC ATGTGAGTATAGCTGGAAAACTTGAGGT CAGACTGGGTTTTGGGTCTGGGTGGAGG GTGACCTTTGAGAAGAGGTATGTGTGCA TGGGGAAATAAAAGGGTAATGCTTTGAT CACATGTAGTGTACAGACATGGGCGTGG GAGCCATCAGATTGGATAAATGTCTTCTT GAGTATAAAAAAGAGTTCATGTATGTATT TTCAAATCTTAATACTTTCTAGAGTAAAAA CAGAACACATGTAAGCATTCAGAATTACA TTCTCA I I I I IAAGCTGTCATCCAAGGGA TGTTTGAGAGCTTCACCTGGACAATTACG TTATTTTACACTGCTAGTTCCTCAGGACC CATTTAGCTGTGCAAAGTG I I I I I GTAAA AGGAACTTCTCCCCAACCTTGTGGTCCT ATCTGAAATTTACTTATTTCTACAGGTAAA CAAGGCCTGTTTG AGTTTGCCTTGATGCACAAAAGTTCTTTT AACCCTATGCTGGCTTGATTAATAAAAAC rs7705018 144405404 TAAAG I I I I I ATCAAAAGAATCAAAGTTTT A/C ACCCTTGAATGGGGAAAAAAAAATAGGG SEQ_0319 K* TATCAAAGGAATCAAAG I I I I IATCAAAA TTTCTGAGAAAGAAGAGAAAGGGTCCCT GAGTCAAAGTTTTTAAAAAAGGAAGAGAC TTGATCCAACAGTTGAAGGAATGGGTAA TTTTGGAGTGAAAATGTCATGCTGTCATT GGTGATGTATGCTGAAACTGGGAGTCCA CTGGTTTAGGAAATGGACACCCAGCTTC ACCTACAGGACCTGCTGGGAGTTGGGCC CACCTGGGCAGTAAAACCAGTGAAGTGT AGGAAAGGTGAGTTGATTTGACTGCTGA ACAATGCATAACCTTAGTCTATCCTCA TTCAATTGCCATATCAAACCACCAAGATT

CAT rs4960473 8930286 GCCCCCCCCCCTTGTATTATGTCACATAA C/T GATGCACAGGTGACAATAGTCTAACCAG SEQJD320 TTGTGTAACTTTGTGGTGCAATCAATACT TAGCTGC I I I I I GTTTGTTTGTTTAAGATG ATTGATAAACAGTCAGTGCATCTTGGCTA ATTTCCTTCGATGCTCTGCATACAGCTTC GTCAAGATGTTGTCCGTCAAGAGTGTTTA AGGAAAATATAGAATGCCAGTCTAAAGTA GCTTGATAGAATTCAGCCAAGTGTAGTG AAACCCTTTCCAATGCA I I I I IAAAAATTG AGAACATTGCACACTGTGTAGCATTGGT TGTTAAGAAGAAATAACATGAGTTCTACC CACATAACTCAATAATACACAATCATAG CTCTTAACAAG I I I I I AAGTGTACC rs9405431 8932904 CCTTTCAGTTCCCACTGCCCCCAAATCAT AH^" CCATCCAATCTGATCTCCCATTCCTTGCC SEQ_0321 CATCTCACATTAGGATACACTTCATAACC AGTGTGAACTCTGCAGATCAGCCCACCT AACTGGGCTCCATTCCTGGTGTCGCTAC CCTCATAGCTCAGAACATGGCATGTCAT CTTTTAATGTCACTAGAAAATTCTTCCTAA GCTCAGCTCAATGACTCTGCTCCTTTCCC AAACCTCATTTTAAGAGCCATCGGTCGCT CACATAAGGAATTGTCTCCCTTCTCCACC AATCCTGTCAGAGCCCTCCACTTGATTTT ACCTATGTCCGACTCCCCTCCTTTAAGTG CAAGGCTGTAATCTAACCATGTCTTG TCCACACTGATTTATCCACTGTTGTACC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9406229 6 8934563 ATAGAATGTTATTTGTTATATTGCAAACAT A/G CATAGCAATTTCAAAATAATTTGAAATTCT SEQ_0322

TTGAATAAGACAATGGTTACTG I I I I I GT AGCTCTATTGCCTTTAATGAATGTGTTTG TATTGTTAGTATTTCATTGAACTCCAGCA - CTCTTTTCCTGTTTTAGTTCCATTGTCCAT TGGAATCACTGACTTTACTACAAATTAGT CAAATGAAAATCAGAATACTTACATCATA GACAACAAACTAGTAACAATGTGAGTTGT GGAATCTGAGTAGTTTTGTTTGATATTGA AATAATTCTTATGTGTTTTGAGACATGTCT GAACATTTTGACAATACAAAGCACTGTAA CAATCATGTGAGAATAAAATTAGG CTGAGTATTAAATATTTTAATGAA rs9379274 8935206 ATTGAGAACATTTTGACAATACAAAGCAC C/T GGCCTTCTAACTCAGGTTGTCCTGAGCT SEQ_0323 TGTAACTGAGTATTAAATATTTTAATGAAT TTGGAATCAGACTGACCCACGTTTGAATC TTTACCTTGTCTATTAGTCCATTCTCGTG TAGGCTCTGCACCATAACTGGGGCAACT TTGCTATAAAGAACAGCTGAGACTGGATA TACCTACTATGTTCTCTGTCAGTTTCCTC ATTTATAAAGAAAAGAGGTTTAATTGGCT ATCTGTAAAATTTGGGTAATAAACTGTAT CACACTTCTGCTGGCTGTATAGGCATGG CCTGCAGGTTTGTTCTAAGGCTTAAGTGA CTGGGAAGGCCTCAGAAAACTTTCAATC GAACACGGCTGTACATATTAATGCTCAAT ATGGCGGAAGGTAAAAAGGAAGCAAGCA AAATAACAATGATCTACAATCCTACATTT CATTTACATAGCCAGAGAAGGAAGAAGA GTAAACAAGTTAACATGTTGAGTCAACAA K* GAGTGAAGGAGGAGGGCTGTAGACTΠT TGACTTATTAATCACCCGGACATGTTCAT AAACAACCACTTCTTGTGAGAACTAGCTA GGGTTAAATCCAGGTTGAGGCACAGTGA TCATGAGAACAGCAGTGGGGACATCTGC GAGGATTTGAAAGTCATTCAACAAATATG CCCCATGATCCAGTCACCCCCTACCAGG TATTGAAGAGTATGCATCTACCACCTGTC CCTCTTCTCCAACACTGGTGGTTACAATT AGGTATTCTTCTAGGCATCCTGGTAGAGT CAACATGAGATTTGGATGGGGCCACAAA GAACAAAACACAACCCCCTTCCTCATAGA TCCAAACCATATCAACTTGTATAAAGAGA GCTTTCATTCCAATTGATGGAATAATAGG TAGCAGTAGCCACCAGTGTAGTCTGTTTA TAAGAAATGCAAAAAAAGAACAACACATC ATACCTGAGACTTA AAAAAGATTA rs6597377 8936885 AAATAAATAAATAAACCTTTCCAGGAAAT A/C TGTTATAAACAAATGTCCAAGAAGTTTTA SEQ_0324 AAGAAAAAGAAAGGAATGCATACATTGAT AGTCATGTAAATCATTTTATACATGCTAT GTTACAATTTACTTCTATAGTTAAGTCATA GTAAATAACAAACATGTTTATGAAAGTTTT AAAATTTGAAACTTAAAAAAAAAAAAAAAC TCCCAAACTCACTTTACTCTCAATTCAGT AAGGAACAGGAAATTTAACTAAAGGCCTA CTGTGTGCTGAGTGAGCAAGGGCTGTGC AAACAACAGTTGCCAAGATGTTCTAAGAA TATGTCATTTGTGCCCCCAAATGGGTGG AGGAAATGGTTAATTGTCAAGTGA TTCCCTAGGGTACCATGTCAGCAATGA rs9505582 8939853 CCTCATAAATGCCAACAATTATTGGCTTG CfT I I I I I I IAAATTCTTAAGTGCTTAATGGCT SEQ_0325 AATTCAAAAGTGGAATAAATTTTGTCCTT CTGGAGGCAACTATGATAGAATGGCAAG GAGTACAAGAGTGATAGCAAATAACCAAT TGCACTAGGCTAGGAGGCAGATGATCAG TTTAATATTTTATAGAGAGAGTTATAGCC GTCTAAGTCTCCACCCTTCTAGAGAGGG ATTTCCTGAACTACCTCTGATATTATTTCT AAGTCCCCAAATCCTTATCCAGAAAATGG GGAA GAAGCAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs2327112 6 8944645 TTCATAC CTGTCAAACATATTATAAAATG A/G AAAATTATGCTATCCCACAATAAACTGGT SEQ 0326

GCAAACAAGAATTAAATAACTTTTGGATT AAATACATTAATGGCAGACTACTGGTTTT

ATTCTGCACAGTTGATCATTTCTGGGTAA TTTCCTATTTGAGTAGCATGTATTCTTAAC

GAAAAAAAATTGGCAAAACTTTATTTGTG ACAAATAGACTTGTATCCTGAAGCAGCAA

AAGCAACCTAAATGCCTAGTGATAGAATA TAAAATTTAAACGAGTCAGGCACTGATAA

TGATTAAAGTTTTAAAAATTGGCCAGGTG AGTAATAGGCAATGTCTAAATATCATTAT

CGGTGGCTCACGCCTGTAATCCCAGCAC TGTTATTAGAGCAAAAAAAAAAGATGTCA

TTTGGGAAGCCGAGGTGGGCGGATCAC GTATTTCTCCAGGGTAAATGTΠTCCATT

GAGGTCAGGAGATCAACACCATCCCGGC AAACATTTAATGGAAAGAAATGTTAATCA

TAACACGGCGAAACCCCATCTCTACTAAA TTTCTTATTCCCTTGCACCCACCTTTAATT

AAAATACAAAAAAAATCAGCCGGGCGTG AATTGATACGCTACA I I I I I I CACGCATG

GTGGAGGATGCCCGTAGTCCCAGCTGCT TCTTTCATACTTTTGAAGCATTTTCTTTGT

CGGGAGGCTGGGGCAGGAGAATGGCGT CAAAATTAGAGTTAAAATTCTAAAAAAAAA

GAACCCGGGAGGCGGAGCTTGCAGTGA TTCTTGTCAAAGAAGTGGACTTTGCTTAA

GGCGAGATCGCGCCACCGCACTCCAGC TATTGCTTTATTATACGAGGTACAAATCC

CCGGGCGACAGAGCGAGACTCCGTCTC ATTTTGGCTAAGGCATATGAGCAACCTAT

AAAAAAAAAAAAAAAAAAGTΠTAAAAATG AATAATAGAACACATTAGGGCACTΠTCA K>

TTCAGAGTCCATAGGCCTG GA ^

RS887847 7 7953022 AGCGTGAATGCTAATGTAAACTATGGACT C/T CCCACAGAACCCATGTTTTCCTATCCAAT SEQ_0327

TTGGGTGATAATGATGTCAATGTAGGTTT TACCTTGACTATGACAACATTAGTGATTC

ATTGACTATAACAAATATACCACCTGGTG GTGCCGTGGGTACACTGAGGCTGGAGA

TAGGATGTTAATAGTGGGAAAGGCTATG GCTTGCATCCATATAGACAGAGAGCTCTT

TATATGCTGGGGAAAGGAATCTATGAGA CTGTGGCCAACAAGAGCAGGCCCAG

AATCTCTGTACATTGAGCCTAACTTTGCT

GTGAACCAAAAACTATTCTAAACAATAAA

GTGTGTCTGTGTGTGTGTTTGTAATAGAA

CAGCCTTAAAACTTGATTTGCTCATATGT

TCATTAGCCTTTCTGCAAGTCACAGAATA

AAAGAAATATGATACTTCATTATAATGGA

TTTTATTCTGTGCATATATAAAACAAGATG

ATCGACATTTACAATCTCAAAATATGCAA

ATACCACAAGCAATTATACTGCACAAGGA

ACGAGAGAAAATTTGATTCCCCTGCATTG

TCACATATTGTATGAATATATAATTTATAT

AGATTTATAACTTGCATACAAATATAATAA

ACTGCAGTTTATATTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10280313 7 7964390 CGCCATCAGGCGTGGATGAACAAATGAC A/C TGAGAGAAAACTTGAAAGCCTAAAAGGA SEQ_0328

AAGCCACACTCCGGCTCGTCCCCCTCAG TATCCTGGATGCTCGCCATATGTAATTGT

ATTTCAGTGGTGGCCTTGGTCAGTCCCT CTTGTTGGGACTGGTAACTAAAATAGCAT

CCACTCCCTCCTTTCTTGGTGACCTGGAT TGCAGGGATATTTACCCAATTTTCATAAA

GCATCCCAATTTTCTGTTTCCAATGATCT AACTATTATGGCTTTATTTTCAAAGCAAG

GGCCTGGAGCAGCTTGGGAAAAAAACAG TAACTACAGAGCCATGTGGCCGGTTGGT

CCTTGCTAAATGCTGTGTAAAGTAATGAC AAATGTTCCAGTGATTAACTGAGAAATG

A rs3807839 7 7965206 GGGGTAGTGGTGTTGAAGGAGATGGTG A/G GGAGAGTTTGTTGGGGTTTCTAGGTTAT SEQ_0329

GTGGTGGTGGTGGAGGTGATGGTGATG GTTACTTTCTCACTCTCCATTTCACCCTA

GTGATAGTGGTGGGGGTAGTGGTGATGA GATTGTCAGTTTTATGTGAGTTTCACAGG

AGGAGATGGTGGTTGTGGTGGTGGTGGT TGAGGCTATGAATTGCAGTGGGACAGGA

GATGGTGGAGGAGGTGATGGTGGTAGT GGTCTGGCCAGATCTCACCCCAGGGTAA

GGTGGGGGTAGTGGTGATGAAGGAGAT CCCAACCCACCCCCTGCCTGGCTTTCAC

AATGGTGGTGGTGGTGGTGGTGGTGGT AGACACTCTGGCAGCTCGATTCCCAAAC

GGAGGAGATGGTGGTAGTGGTGGAAGA CT

GGTGATGGTGGTAGTGCTGGGGGTAGT ^

GGTGGTGAAGGAGATGGTGGTGGTGGT ^

GGTGGTGGTGGAGGTGGTGATGGTAATA

GCAGTAGTGAAAGAGGTGAGTGGTAGTG

GTGGTGGTAAGGGTGACGGTAATGGTTG

TGGTGGTTGTTGCGATGGTGGTGGCAGT

GGTGAGGATAACAGCCACGGTAAAGGCT

CCAGTAATGACATAGTGCTGGTAATGGG

GATGTACTTACTATGAATTCTATAGTAGA

TCCAGAAGACAACCATGCGAAGCATCAA

TAC rs13226206 7 7967941 TACTGTGATACATTAAGTATTAATGGCTT C/T TAGATGAAAACCATTCTAGAGAGGTAACA SEQJ3330

TCACCATCATGTTTTGTGGCATACAAAAC AAAGAACAAAAGTACAGTTTATTTGGTTG

AATATGCAACATACTTATATCGATCTAATA GTTTCTGAACATTTATTCTTAATATTACCA

GTGAGTTGTATCGTAACAGGATTCCATTA TAACATCATTATACCCTAACAGATATATTA

TATCATATTTGAGTCCACATAAAGAAAAA TTACTCCTACTAAGATTATATCACAATTAA

TATTAGGTTGGTGCAAAAGTAATTGTGGT ACCATGAACTATTACTTAAACCATAATTTA

TTTTGACACTAAAAGTAATGGAAAAACCC AGGAAGGCTCTGGGGATGTAAA

GTAATTACTTTTGAACCAACCTGATAATT

ATCTATCAGCTTGAGATTCTAATGTGATA

TGTCATCATTGAAAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10282493 7 7969769 ACCTTCTCAAGTGAGGATATTTGAATATA A/T GATTCTCATTGTATTGAATCCTGATGCAG SEQ_0331

ATAATTAAAAGTAACTGAGTTTATGGGAC TAAAAAAAAAAAAAAAAAAAAAAAAAGAA TTGTACAATCTCCCCTTTAGCAATGTCAA AGAAAGAAAGAAAGAAAAAGACTCTGCT ACAAGTATTTTAAAGGAGCAGGACCAATC GGGGGCACAGTTCTCTCTTCAGCATTCT ATTAGACTCAAGTTCACCACAATTCATCT GAGTCCTGGAATAATGATGCTTTCTGCAA CCCAGGAACATGTATCTCAAGGTTCAAG TGGACTTTGCTTGTGATATAAACAAAACT GTTCAATTCGCGCTTTTGGATTGCAGT TTACTTTTCTCAAGATTTTCTAGTGGCCC CTCTAGCTTCCATACCTTTAAAGTAGTAA ATTCATATGGTTGATAA rs2058519 7 7987814 GAGAATTTCCCCCAAGATGGCAAGAAAA A/G GAGAAATACACGTTCCACTGCTAAGAGA SEQ_0332

AAAATGAAAGCTGGGCGTGGTGGTTCAC AAGAGAGGAATGGGTGGTTAAACAGGGC GCCTGTAATCCCAGCACTTTGGGAGTCT CTTGGAGACAAAAATTCCACCATCTGGA GAGGCAGGTGGGTCGCTTGAGCTCAGG GGGCAAAAGAGAGAAAGGATCATCTCAT AGTTTCAGACCAGCTTGGGCAACGTGGC GTGCTTGTCAGGTTCAGCACTTGAGGTA AAAACCGGGTTTCTACAAAAAAATAAAAA AGGAAAACGAGGTGGGGCTGAGTGAGA AATCAGCTGGGTGTGGTGGTGAGCACTT GGTTGAAAAGAATGTGGGGGATAAAGCG ATAGTCCCAGCTACTCAGGAGGCTGAGG GGGAG K> CGGGAGGATCACTTGCACTGTGCTCCAG 00 O CCTGGGTGACACAGCCAGACTGTATCTC AAAAAAAAAAAAAAAAAAAAAAAACAGAG AGAGAGACAAATGAGACAATTCATACTCT TTAATGCGGGAAACACAAACACGTCCAC TCTTGGCAGCATCATTCTACCATTGCGCT GAAGAGAATTACACCTGAATAGTAGGGG AAAGAAACCGAAGAATGAGTGAGAAAGA CTTTAAACCAAGGCCAG rs7804613 7987906 GTCCACTCTTGGCAGCATCATTCTACCAT A/G GAGAGAAAGGATCATCTCATGTGCTTGT SEQJ3333 TGCGCTGAAGAGAATTACACCTGAATAG CAGGTTCAGCACTTGAGGTAAGGAAAAC TAGGGGAAAGAAACCGAAGAATGAGTGA GAGGTGGGGCTGAGTGAGAGGTTGAAA GAAAGACTTTAAACCAAGGCCAGGGAGA AGAATGTGGGGGATAAAGCGGGGAGGG AATACACGTTCCACTGCTAAGAGAAAGA GCACAGAGTGGGCTGGCCAAGCTGATG GAGGAATGGGTGGTTAAACAGGGCCTTG CTTAACCTTGCTCAAGGAGGGAGCAGGG GAGACAAAAATTCCACCATCTGGAGGGC TAGAGAGATTTCAGGGACAGGGAAGTTG AAA AAGTCAA rs 13276304 20237115 AGATTGGTGCTATCACCTTCATTCTATGA G/T CTATTTGCTCTTGGGCATTTGAAATCAGG SEQ_0334 GATCCTTACACAGAAGGCAGTTACGATG TTCTTGACAGATATTTGAAAACCAAATAA ACTTGCTTCCAACAGGCAGGCAGCGTGT TGTACAGAGAATTTTGAAGTΠTAGCCAA ACTAATTTGAAGTAAGGAGTCAGTCCGAA GAAAAGCTCTCTAGGTAAAAGACAGTGG GGACTTACGATGTTAAGCAAAGAAAAATA CAGTAAAAGCAGCCCTGAATTTTCTCCCT AAAA I I I I I GGACTCATTTTATCTCACTTT TATATTTCATATTGGGGTTTTCATTTATTC CACCGAATGAAGCCTGAGCTCACTTCT CTGTTGGAGGAGGCATAGTGGATCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs1021201 8 20240373 TATTCAATGTTAAATTTTCCTCTATCAATA A/G CAACACAACCACTCCAATATTCACACCAG SEQ_

TTATATTACTTTTCTCGATAGCATAAATGA GGACTAACTAGATGATTTAAAAAAAAAAA TAAATTACAAAATATTTAATATTTATAAAG AACATTAGTTTA I I I I I CAAATTGACAAAA ACCCAAGAATGTATAAAAAATAAAGAGAA GTTTTATTTATTTATTGCATACAACCTTTT AATGAATGCCTAAAATAACATCAAACTAA GTTATGAAATATCTATCCATTGTGGAATA ATTACCAAGCTTACAAGTATGTCAGAGTT ACTAAATTGAGTGTATTATA * TAAGATGTCTGCGTAGGGATTCAGAAAC TTATCCCTTCACACCATCACCACCACAAT AGCCTCTTGCCC I I I I I CTTACTTTAAAA

GAAAAAAAATTCCACACACTTGGATTCTA GAAATAAAAAACAGTCAAAGACGACGAA AAACATTCCCTAGGGAGTTTTGTATGATG AGAGGTTGGAGGGACAACTATTTGGAGC AGAGTTTTCTGAAGAACAGGGCCAGATT GAGAGGTGATAGAAGGAGTAGAACATGG AGACAGGATAATACGGAGAAGAAGAAGA TCTTCTGGGTTAGAGGTGTCCAGGAGTT K* GTTGAGCACTAGAGAATAAGTGAAGACA CAGCATGTTAATAAGAGAGTCTCTAGACT GTACTTATGTCTCCCTGAATGAGTTTGGA AGCCGTCAGTAAGAATTTGATTTTCTGTT AAATTGTTCTTTAGGTGCAACACTTTACT GCTAGGTTGTATCAGTTAAGGCTTTTACA TGGGTCATGCAAGATACACTTTACTCATC TTTAGCTAACAGCCACTACTGTCACTTAT CCCTCCTGCTCTCAACCGTCTCCCACAT GATGGCAGAGACCATCAAAACACCACTC CAGGTATGCCTATCAGGCCTCCAGCATC CACAGTCCTAGATTCAGGAGAAAAGCAA GCAAGAAAGAGAGCAGGAAGTCCTCTTT TCTACTCTCACATCTΠTAAAGGTCTACC TTTCTGTTTTCCACCTAAGACCCAAGAGA

RS7815591 8 20240699 GAAAACAGAAAGGTAGACCTTTAAAAGAT C/T TAGCTAAAGATGAGTAAAGTGTATCTTGC SEQ_0336

GTGAGAGTAGAAAAGAGGACTTCCTGCT ATGACCCATGTAAAAGCCTTAACTGATAC CTCTTTCTTGCTTGCTTTTCTCCTGAATCT AACCTAGCAGTAAAGTGTTGCACCTAAA AGGACTGTGGATGCTGGAGGCCTGATAG GAACAATTTAACAGAAAATCAAATTCTTA GCATACCTGGAGTGGTGTTTTGATGGTC CTGACGGCTTCCAAACTCATTCAGGGAG TCTGCCATCATGTGGGAGACGGTTGAGA ACATAAGTACAGTCTAGAGACTCTCTTAT GCAGGAGGGATAAGTGACAGTAGTGGCT TAACATGCTGTGTCTTCACTTATTCTCT

G

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6651486 8 20241030 GTTTTGATGGTCTCTGCCATCATGTGGG A/T AGTTGTCCCTCCAACCTCTCATCATACAA SEQ 0337

AGACGGTTGAGAGCAGGAGGGATAAGT AACTCCCTAGGGAATG I I I I I CGTCGTCT GACAGTAGTGGCTGTTAGCTAAAGATGA TTGACTG I I I I I I ATTTCTAGAATCCAAGT GTAAAGTGTATCTTGCATGACCCATGTAA GTGTGGAA I I I I I I I I CTTTTAAAGTAAGA AAGCCTTAACTGATACAACCTAGCAGTAA AAAAGGGCAAGAGGCTATTGTGGTGGTG AGTGTTGCACCTAAAGAACAATTTAACAG ATGGTGTGAAGGGATAAGTTTCTGAATC AAAATCAAATTCTTACTGACGGCTTCCAA CCTACGCAGACATCTTAAACTCTGACATA ACTCATTCAGGGAGACATAAGTACAGTCT CTTGTAAGCTTGGTAATTTAGTTTGATGT AGAGACTCTCTTATTAACATGCTGTGTCT TATTTTAGGCATTCATTTTCTCTTTA I I I I I TCACTTATTCTCTAGTGCTCAACAACTCC TATACATTCTTGGGTCTTTATAAATATTAA TGGACACCTCTAACCCAGAAGATCTTCTT ATATTTTGTAATTTATCATTTATGCTATCG CTTCTCCGTATTATCCTGTCTCCATGTTC AGAAAAGTAATATAATATTGATAGAGGAA TACTCCTTCTATCACCTCTCAATCTGGCC AATTTAACATTGAATAGAAAAGCATTGAA CTGTTCTTCAGAAAACTCTGCTCCAAA GATATGCATATCTTTACCA rs 12544090 20242704 GGCTTGTAGAGGAAAAGGAAATGTCTGA A/C AACAGGAAGAAATATCAAAGCCAATGGT SEQJD338 GATGATCAGCCATCGGGAGACAAATACT AGAGACAAATATTGCTCTAAGATATCAGC GCTGTCTAGGAGACATGTCTTATATTCAG AAGTGTCCAAGGAGTTTCCTGGGGGAGA AGCTCAGTATAATACTGCATTCTAGCAGA TCACACCCAAGCTGGGCTTTAAAGCATG CAGGTCCTATATTCAGAGCTTAGTATAAT TGAGGATTCAGAGGAAGGCTTCTTTGAG ACTGCAGTCTTGGAGACATGTCTTATATT CATGGCAACATCATGTGGCCATGCACCT CAGAGCTTAGTATAGAGTAGGATACATA GTCATGTGGGGGCCAGTGATGAGGCTA

GGCA rs10503677 20248324 ACTCTCACTGAGTTTGCCTGTGGTCCTGT G/T TTCCCTACCTGCACGAGGGATGGTGGAA SEQ_0339 TATTCTTGCATCCAGTTCATTTCATGCCT GCCTTGCCTGCCACCCCAGTTTTCTCAG TGCCATTGGCTTGGCCTTAACTAATAGC AAGCGAATGCTATGTGCATCCACTCCTTT GATGGCCTGTGTCTTCATGCTGTCTTAGT CTAGCATCTTCTAATGATCTTTCATGTCC GCACAGCCGCACCTGCACCAAGCTGTAC CTACTGAATGTTTCCCTTTGCATTGCCGC TGCAGACATAGCTGTAAGCTTCTGTTCTT CCATGCCCACAGGACTGATGAAGCACAC CTCTTTAAGAATATCCCTGAGAGTCTCG TCTGTGGTTGTCACTAGTGATCTGAAGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs900956 8 20255235 GCCAGTGGGTGGGGACAGGAGAGAGGA C/T TGTAGCTTGGGGACTAAATCCAAATCTCC SEQ_0340

AAAGGAAAAGGAGGAGGTGATGCCCCGT AGGCTCCCAGTTCAAAACACGTCCCCCC GATGGGTCCCCAGCAAACTTTTCCCTCG ACCAGAGCATGAATGGTCCTAAGCACAC GCCCTCACCCCACCCCATCCCAAAGCTC TCTATTAAAATGCAAATGTTCCCCAGGAG TTCCTCATGATGACACAGGATTATTTATT GTTTAACTCCAAGTTATTAGCACCTTAAT TTGGGAAAATGTGACAGGGAGGGGCTGA GTGAGGGATGTGAATTGGGTTAACATGC ACGGTGTGAGGTGGGTAAGATGCTTGCA TTC I I I I I I CTTTTAATTGAACTCGATCTG TCGTACTGCCTGGGTTTGAATCCTGGTT GTTCAAAAGGAGTACAGAAGGGGAGTGG CTGCTCCACAGTAGCGACTGACCTTCAG GAGGGGGGAAATT TAAGACACTTATTGACTTCCCTGGGCGTC AGTTTTCTCATCTGTAAAATGGTGCCATG AATAGTACCTGTCTCATAAAATTGTTATAA AGTGTATGTGGGATAAATTATCTAGTCCA AAATTTTAAATTTAGGGACCAGTTGGAGA GTCTAAGCAGACAAAGAGAGAGAGAGAT CACTTACCCAAGGGCAAAGGGCTAA rs900955 8 20255809 GCTCTGCTGGGTGCACTTCTCAGTTTCTT A/G GGATGTTACCTGTTACATTCAACAGGGT SEQ_0341

TTCATCAGCATATCTGATGTCCAATTGTA GTGATGGTTGGTCAAGAGGGTTAGCGAT TTTTGAGTACTTCACTTTCATGCAGTTAAT TGCCTTTCACGAAACTGTAAACACCACCC TATTTAGTTTTAACCTACAAGATTTGCAG CCTCTGTCTAGCAAATGGCCCAGCTCTA GAAGATCTTTGTTTTCATGAAACCAACTA GCTTGTGTGGCCAGTGGGTGGGGACAG TCATCTGCAAATTAAAAACAGTTGCTGTC GAGAGAGGAAAAGGAAAAGGAGGAGGT AAGTACTCAGATCTGAATGTGTGTGC GATGCCCCGTGATGGGTCCCCAGCAAAC TTTTCCCTCGGCCCTCACCCCACCCCAT CCCAAAGCTCTTCCTCATGATGACACAG GATTATTTATTTTGGGAAAATGTGACAGG GAGGGGCTGAACGGTGTGAGGTGGGT rs11204110 20256243 GATGGGAATCCTACCCTCAGTGGGATAT A/T TCAGAAGCTGGGAGTATATCCTGAGGAC SEQ 0342 GGTGCTGGAGCTGTGGGTTGGAGCGAT AGACACAAAGAAACCCCATGGTCCGAAG GTTCATGGGAAGAACATGTTGGCAGGGA ACCTACCAGAGAACATGCAGTTCAACAG TAGTGGTAAGGGGAGTGAAGGGAAGAG GAATGAAAAGAAAAACAAATGTAAAAGTC AGAAATTCAGTTTCCTGGAAGATTTGTGA GTCTCCTCTGTATAGATCTCTTAAGATGG CCAGTTCGTTGAGATGGCATTTCCATGG AAGTGCCAGCAGCTACAGATCCTTCCAA AATTCAGGAGACTGCATGGAACATAGATT GGTGCCAGGCAGTGCTCTAAGTGGATGT TAAA CA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1872346 8 20256683 AGGAATGCCAGACAGATAAGAAACAATTT A/G ACCCAGCCTGAAGTCCCCAGGGACTGGA SEQ_0343

GCCAGGAGATCACTGAGAGGTTCCTGAC CTCAGGTGTCTGGACTGAGGAAAATCCC

ACCCAGGAGGCCCAGGTGCCTGAGGAG TCTGGTACCCACTGTCCTTTCCTCTATGA

GGGCAGCAAGCAGGCAGAGTAGATGAA CACTCAACCAGCTGAGTACGGCCCCTAA

GTCTACACACAGAGCACCTGTGACCCAT ACCAGCTCATCCGCTTCAAATATGGGCT

GTTCCTCCCTGCCCCATCCGCAGGGGTG CCAGCTATGACCAAAAGAAAGTGTCTTAA

CCTGCTCCTCCAAGATTAGACTAAGGAC CATGCGTGCTGTGAGTCCTCCGCAAAGT

AAAAT AG rs4376510 8 20259350 AAGGTGAAGGTGAAGCAGGCACCTTTTA CfT TAATTCCTAGTACCTCAGAATGTGACTGT SEQ_0344

CATGGCCAGAGAAGGAGGAAGAGAGAG ATTTGGATACTGGACCTTTAAGTAGGTAA

AGAAGGGGGAGGTGCTACTCACTTTTAA TTAAGTTAAAATGTGATCAGCAGGGCAG

ACAACCAGATCTCATGAGAACTCACTATA GCCCTAATTCAAGATGCCTGATGCCCTT

ATGAGAACAGCAAGGGAGAAATCCACCC CTAAGAAGCGGAGATTAGGGTAAGGATA

CCATGACCTAGTCACCTCCTATCAGGCC CACACCAGAGGGAAGACTATGGGAAGG

CCTCCTCCAACATTGGGGATTGCAATTTA CAAAGGGAGAAGACGGCCATCTATAAGC

ACATGAGATTTGGGTGGGGACACAAAAC CAAGGAGGGAGAGACCTCAGAAGAAACC

CAAAGCTATCACTGAGGATTGTTCCACTG AATCCTGCTAACACCTCAATCTTGGACTT £>

CATGGATGCTCTACCCAGTCACACCATC CCAGCCTCCAGAATTGTGAGAGCGTCCA *-

CAGGCCCAATCCAGCCATGTCTGGAGAC TTCTGTTGTTGAAGGCACCCAGTCAAATG

TGACACCAATCTGTATCTGCAGTGCTCCA C I I I I I I ATGGCATCCCAAGCAGACTAAT

GTCGGCTCATTCTCACCAGGAACTGTTC GCAGCCCTGTATTACCCATTCAGTCCAA

ATTGCAGGGAGAAAGGCCTAGCCAAATT CAAGCATTTGCTGAATGCTTTCTACATGA

TCCTTATTCACCATCAGAGAAATCAAATG CAGGCTGGGTCAGGGATATATTAGGAGG

TCAGAGCTGGAAAGATCCTTGATACCAG GAAGAGATGAGGTTTCCATCATTTAGAAA

TGGGTCCCTGTTTGGGGTTGAATTGTGT CCTCTGGCCTCCTTGCATTTTGCATATCA

CCCTTTCAAATCTATGTGTT ACAAACCAAGGCTCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence ^' SNP Base 3' Flanking Sequence SEQ ID rs2062348 8 20260042 CCAACAGGATATGTGTATTACATGTGTAG A/G CAACACAACAAATGAGGATGGAGTCTGG SEQ_0345

AGAGAGAGAGATTTATTTTAAGGAATTGG ACTAGA

CTCCCATATTTGTGTTGGCTGGAAAGTCT

GAATTTTGCAGAGCACGCTGTCAGGCTG

GAGACCCACGGAAGAGTTAAGGTTGCAG

GTCAATTCCAAAAGCGGTCTCCACGAGG AGTTCTCTCTTTCTTGGGAGACCTCAGTC TGTTTCACATTAAGGCTTTCAACTGATCT GATGAGGCCCACCCACCGTGTGGACAGT AATCTGTTTTACTCAAAGTCTGCTGTTTTA AATGTTAATGTCATCTAAAAATCACACTC ACAGAAGCATATAGTGTGTTGTTTCACCA ATTATATAGGGACCATGGCATAGCTAAGT TGAGACATAAGATCAGCCATCACAGCGG GTGACCAAAGGTTCACAGGGCATATCGG GTATACCTCCATGGCAGGCTTGACCTCA

TTTTAACTTAATTACCTACTTAAAGGCCC K.

AATCTCCAAATACAGTCACATTCTGAGAT Sn

ACTAGGGATTTGAACATTTAGATTTGGAA GAGACACAATTCAGCCCCAAACAGGGAC CCGTTGGTCTCAAGGGTCTTTCCATATAC TTAAAGTGCCACAGGAGCCAGCACTGTC TCTGGAGCCAGGGCCCCTGTGTCTAGGT CTGCCAAAGGTAACTGAAGAGGGCTGCA CAGGCCTGTGTCATTAGCACACACAGAA CAGCACAGATTGTCGAAGCCAGATGGCA GACACCTGCTCTGAGGGCAAGTGCAGAC CTGGAGCAAGTGTGTCCTGGATGGCATC CAGCAGGCTTCCCTGAAGGCCCATCCCA

TCCTAATCATTATGCTTTCCACTTGGAGC

TTCGCCTGCACTTTCTTCTTTGGTTCTTA

TGGCCACCCGTGGAGAAGGCTGGAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4397421 8 20260788 TGTTCTGTGTGTGCTAATGACACAGGCC A/G TAAAACAGACTGAGGTCTCCCAAGAAAG SEQ_0346

TGTGCAGCCCTCTTCAGTTACCTTTGGCA AGAGAATTCCTCCTGGAGACCGCTTTTG

GACCTAGACACAGGGGCCCTGGCTCCA GAATTGACCTGCAACCTTAACTCTTCCCT

GAGACAGTGCTGGCTCCTGTGGCACTTT GGGTCTCCAGCCTGCCAGCCTGCTCTGC

AAGTATATGGAAAGACCCTTGAGACCAA AAAATTCAGACTTTCCAGCCAACACAATT

CGGGTCCCTGTTTGGGGCTGAATTGTGT ATGGGAGCCAATTCCTTAAAATAAATCTC

CTCTTCCAAATCTAAATGTTCAAATCCCT TCTCTCTCTAAACATGTAATACACATATC

AGTATCTCAGAATGTGACTGTATTTGGAG CTGTTGGTTCTGTTTCTGTCGAGAACTCT

ATTGGGCCTTTAAGTAGGTAATTAAGTTA GACTAATATACCCCACCTTATATCGTCAA

AAATGAGGTCAAGCCTGCCATGGAGGTA TGTGGGCTGCTATAACAAAATACCACAG

TACCCGATATGCCCTGTGAACCTTTGGT ATTAGGTGGCTTAAACAACAGACGTTTAT

CACCCGCTGTGATGGCTGATCTTAGGTC TGCTCACAGTTCTAAAGACTGGGAAGTC

TCAACTTAGCTATGCCATGGTCCCTAGAT CAAGATCAAGATGCCCACAGATTTGGTT

AATTGGTGAAACAACAGACTAGATGCTTC CTTCCTGGCTTGCAGATAGCTGCCTTCTT

TGTGAGTGTAA I I I I I AGATGACATTAAC ACTGTGTCCTTGCGTGATGGAGAGAAAG

ATTTAAAACAGCAGACTTTGAGTAAAACA TGAGCTTTGGTCTCTCTTCCTCTTCTTAC

GATTACTGTCCACAGGGTGGTGGGCCTC AAGGGGACTAATCCTATTATGGCAGCCC ^,

ATCAGATCAGTTGAAAGCCTTAAG CACCCCAATGGCTTCAACTAAACCTAATT ^

ACTTCCCAAAGTCCCACCTCCAAATACCA

TCACACTGGGGGTTAAGAGCTTCAACAT

ATGAATTCTAGGGGGACACAAGCGTTAA

GTCTGTAACACCCCGTTATCCCCATTCTC

AAATAACTCTCATTTATTGAGCACTTATTG

TGCTTACTAGCCAATGTTCTACACATATC

ATATGCAACCATACGTGAGTATTATTGTC

TCTGTTTTACAGTTGGTGACCCTGAGGC

ACAGAAAGCTGAGGGAATTTGTTCGAAG

TCACACAGCTGGTAAGTGTCCTGGAGTC

TACTTTCTTGACCTCTGTGCTGTGCTGCC

TCTTGGGTCCAAACCCACATACCTGAAC

ATAAAATGAGCGCTTACACCTATCCAAAG

AACAGAGACAGTGCAGCCTCTCAGGTGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6586909 8 20260832 TGTTCTGTGTGTGCTAATGACACAGGCC C/G AGACCGCTTTTGGAATTGACCTGCAACC SEQ_0347

TGTGCAGCCCTCTTCAGTTACCTTTGGCA TTAACTCTTCCCTGGGTCTCCAGCCTGC

GACCTAGACACAGGGGCCCTGGCTCCA CAGCCTGCTCTGCAAAATTCAGACTTTCC

GAGACAGTGCTGGCTCCTGTGGCACTTT AGCCAACACAATTATGGGAGCCAATTCC

AAGTATATGGAAAGACCCTTGAGACCAA TTAAAATAAATCTCTCTCTCTCTAAACATG

CGGGTCCCTGTTTGGGGCTGAATTGTGT TAATACACATATCCTGTTGGTTCTGTTTC

CTCTTCCAAATCTAAATGTTCAAATCCCT TGTCGAGAACTCTGACTAATATACCCCAC

AGTATCTCAGAATGTGACTGTATTTGGAG CTTATATCGTCAATGTGGGCTGCTATAAC

ATTGGGCCTTTAAGTAGGTAATTAAGTTA AAAATACCACAGATTAGGTGGCTTAAACA

AAATGAGGTCAAGCCTGCCATGGAGGTA ACAGACGTTTATTGCTCACAGTTCTAAAG

TACCCGATATGCCCTGTGAACCTTTGGT ACTGGGAAGTCCAAGATCAAGATGCCCA

CACCCGCTGTGATGGCTGATCTTAGGTC CAGATTTGGTTCTTCCTGGCTTGCAGATA

TCAACTTAGCTATGCCATGGTCCCTAGAT GCTGCCTTCTTACTGTGTCCTTGCGTGAT

AATTGGTGAAACAACAGACTAGATGCTTC GGAGAGAAAGTGAGCTTTGGTCTCTCTT

TGTGAGTGTAA I I I I I AGATGACATTAAC CCTCTTCTTACAAGGGGACTAATCCTATT

ATTTAAAACAGCAGACTTTGAGTAAAACA ATGGCAGCCCCACCCCAATGGCTTCAAC

GATTACTGTCCACAGGGTGGTGGGCCTC TAAACCTAATTACTTCCCAAAGTCCCACC K.

ATCAGATCAGTTGAAAGCCTTAAGGTAAA TCCAAATACCATCACACTGGGGGTTAAG ?α

ACAGACTGAGGTCTCCCAAGAAAGAGAG AGCTTCAACATATGAATTCTAGGGGGAC

AATTCCTCCTG ACAAGCGTTAAGTCTGTAACACCCCGTTA

TCCCCATTCTCAAATAACTCTCATTTATTG

AGCACTTATTGTGCTTACTAGCCAATGTT

CTACACATATCATATGCAACCATACGTGA

GTATTATTGTCTCTGTTTTACAGTTGGTG

ACCCTGAGGCACAGAAAGCTGAGGGAAT

TTGTTCGAAGTCACACAGCTGGTAAGTG

TCCTGGAGTCTACTTTCTTGACCTCTGTG

CTGTGCTGCCTCTTGGGTCCAAACCCAC

ATACCTGAACATAAAATGAGCGCTTACAC

CTATCCAAAGAACAGAGACAGTGCAGCC

TCTCAGGTGAGTGCACCAGTCCCCTGGC

CACAGGAGGGACATGCAGATTTCTGGGA rs4921704 8 20262371 GGGAACATATGGAGGAAAAAGCTACAGT A/G AGATG H I I I i CTCAAGGTGTGTTAGCTG SEQ_0348

TTAGAACATGATCAGGAAAGTGCTGCCA AGCCCTGGGCAGCTGCTGTCAGGCTCCT

GCGATGAGGGAGCAGATTACCCTCAAAC GTGGGCAGGCGCTTTCAATCTTGGCTTC

ACTGTGTGAAAAATATTTACACTATGTGC TGTGGCCTTGGTAGAGGGCCACAAAAAG

AGTATTAGTTTTATGATGATGATGATATAT CTTCTGAGGTCATCTGCGAACATTATTGC

ATAACAAATAACACATTTTCTCACTTTCAA TTCTATGGGCATTTTCCTGGGAGACCTTG

TCTGCTGATAATGGTCTTGGTGACATT GATACATTGCTTTGACCAGATTTGCAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs900954 8 20262537 TCTCACTATGTTGCCCAGGCTGGTCTTG A/T CTCCCAGGAAAATGCCCATAGAAGCAAT SEQ_0349

AACCCCTGGCATCAGGTGATACTCCTGC AATGTTCGCAGATGACCTCAGAAGCTTTT

CTCAGTCTTCCCAAGTGCTGGGATTACA TGTGGCCCTCTACCAAGGCCACAGAAGC

GGTGTGAGCCACCACACCCAGACTGGAC CAAGATTGAAAGCGCCTGCCCACAGGAG

CAGA I I I I IAGAGGAGTCTGAACTCAGTG CCTGACAGCA

CCACTCTTGGCTGCTTTGCTCATTAAGAA

AATGGATGTGCCCCTTTTCATTTGTAAGG

ATACTTAGGAAGTGGCAAAGAGCACCAA

CTCAGAGCCTTGAGACCTGTGGCCCCAC

GACAGCTCCATCATGGCCTTGCTACATG

ACTTTGGATAAACCAACAACCCAACCATG

GAAACTGGAAAAGTCATCAAAAACTCCG

ACAGTGAATGACAGTCTTGGACCATTAA

G I I I I I I GCAAATCTGGTCAAAGCAATGT

ATCCAAGG rs871403 8 20263308 CTGATTGCTGTGGTTTCTGGCCAGGGAT C/T GGGCATTTGCAGAGAAGAAACACTTGGG SEQ_0350

GGCCAACAGATGTGCACCAGCAGCCTCC GAGGTCACAGGGAACAAAAAAAAAGCAG _W

ACGGGTCCGTGTACAGATATTGGGCAAA TGGAATGTCCTTTGCCTCTGCCACTCCCT §g

TTTCCCCAGCATGATGCAACTCTGAGAC TTGTAATGGTAGTTCTTATTTGAGACAAG

AAGGAGGGACCCAGAGAGAGAGAGAGC GCACACGTGAGCAATTTGGAATCTGGAC

AGCTCCAGCTACTCGTGTGAACAGCTCA AGGATTTATTTTGAGGACACACCCTGTGT

GA I I I I I AAGGCCTGCTGGTTGGAACCC TTCTGGACCAGA I I I I I I I I I I AAACAGG

CGCGGCACTGGCTCACCACTCATTACAT GTCTTGCTCTGTCACCCAAGCTGGAGTG

GCTGGGGAACTGTGGGCAGTAATTAAGG CAGCGCTGCTATCATAGCTCACTGTAGC

ATTACCCAATGGCATCAATTAGTGCCAAC CTGGGACTCCTGGACTCAAGCCATCCTC

AAGAGGGCTCAGTTGGACGTGTTGACTC CTGCTTCAGATTCCCAAGTAGCTGGGAC

TCCAAGAGGGGATACAGAGGAGGGGAA TATAGGTACCTGCCACCACTAA I I I I I I I

GGCCATCTCTTAC TTACAATTTTTATAGAGACAGGAACTCAC

TATGTTGCCCAGGCTGGTCTTGAACCCC

CTGCTTAGGTGATACTCCTGCCTAAAATG

TTCCCCAAGGCTGGGATTACAGGGGTAA

GCCCCACACCCAACTGGACCAGATTTTA

GAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4922163 8 20264224 ATTCTTGGCCTAGGTGGACATTTTCAAAG A/G GTATTTTCAGACAGTGATTGACTACATTG SEQ_0351

TTCTCCTAGCTTTAAATTATTCATAGGCA AAACCATGGAAAACAAAATG I I I I I I I GC GTTAGAGGGAGTCAGGGAGGGTTTGCCT AGTAACCGAAATGGAAAAAATGGAACTG AAAGCGCCGTTTTCACTCTAAGTTCTCAT AAGGTCGGGTGCAGTGGCTCATGCCTGT TTAAGGCAGGTTGGTGCTGGAGGAAGGT AATCCCAGCACTTTTGGAGGCCGAGGTG CACACCCTTTGGGTTCAGACATAACTTG GGTGGATCACGATGTCAGGAGATCGAGA GCTTATTCAGAGGACTAAATAAGTTAATA CCATCCTGGCTAACATGGTGAAACCCTG CAGTAGGTGGCCCTTTATCTTTGGGGGC TCTCTACTAAAAATACAAAAAAATTAGCC ATGTTCCAAGACCCCCATTGAATGCCTG GGGCGTGGTGGCGGGCGCCTGTAGTCC AGACCTTGAATAGTATAGAACCCTATATA CAGCTACTCAGGAGGCTGAGGCAGGAG CACTATG I I I I I I I CCTATACATATGTAGC AATGGCGTGAATCCAGGAGCCGAAGCTT TATAATAAAGTTTAATTTATAAATTAGGCA GCAGTGAGCCAAGATCGCGCCACTGCTC CAGTAAGAGATTAACAACTGATAAGAAAA TCCAGCCTGGGAGACAGTGTGAGACTCT AATTTATAATAATATAAGGTAATAAAAGTT GTCTCAAAAAAAAAAAAAAAAAAAAAAAA ATGTGAATGTATTCTCTCTCTCAAAATAT AAAGGAACCGAAGATAAGGGGAGACTAC CTT TGTATACATTTAAGTGCTAGGCAGTATGG CTGCCCCGTAGGAAGCTCTCTGGGTGTG K* ACAATTGTTGTGGAGATTAGAGATTATGC C rs4921705 8 20264821 AGGAACCGAAGATAAGGGGAGACTACTG A/C ACCCTGAGTTTATTGTCAAATTTGTGCTC SEQ_0352

TATACATTTAAGTGCTAGGCAGTATGGCT TTTAGAAACTGATTGGTGCTCTAAAAATC GCCCCGTAGGAAGCTCTCTGGGTGTGAC ACCTTGGATATGGGAGCGAAAAGCCTGA AATTGTTGTGGAGATTAGAGATTATGCCT ACTCTAGTGTTAGCTCTGCCATTCATTGG GTAAAGCCTGGTAAACAGTAGCTAATAC GCACATAAAGGCCAAGTCACTCAATCTTT CATTATAAGCCTAGTTCAGCACAGGAAG I I I I I I I I I I I I I I I I I I I GAGACTGAGTCT CTTCCCAAACAAAAATCATCGCTTTGCCC CGCCATGTCTCACCCAGGCTGGAGT C

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4921706 8 20265001 CTGGGTGTGACAATTGTTGTGGAGATTA A/G TGTCTCACCCAGGCTGGAGTGCAGTGAT SEQ_0353

GAGATTATGCCTGTAAAGCCTGGTAAAC GAGATCTCAGCTCACTGCAACCTCTGCC

AGTAGCTAATACCATTATAAGCCTAGTTC TCCTGGGTTCMGTGATTCTCCTGCCCC

AGCACAGGAAGCTTCCCAAACAAAAATC AGCTGGGATTACAGGCATACGCCACCAC

ATCGCTTTGCCCCAACCCTGAGTTTATTG GCCCAGCTAATTTTGTATTTTCAGTAGAG

TCAAATTTGTGCTCTTTAGAAACTGATTG ACAAGGTTTCGCCATGTTGGTCAGGCTG

GTGCTCTAAAAATCACCTTGGATATGGGA GTCTCGAACTACTGACTTCAAACGATCCA

GCGAAAAGCCTGAACTCTAGTGTTAGCT CCCACCCCGGCCTCCCAAAGTGCTGGG

CTGCCATTCATTGGGCACATAAAGGCCA ATTACAGGTGTGAGCCACCATGCCCGGC

AGTCACTCAATC I I I I I I I I I I I I I I I l I I I TAAGTAGCTTAACCTATAGGGCTTACTGT

TTTGAGACTGAGTCTCGCC CCTCAGGTGAATTAAACATGGAGGAGTC

TGCACTGGGTAAAGGGTTAAAGGGTGTC

CTGGCAAAATACATGTCCATCCAGAACCT

CAGAATGTGTTCGTATTTGGAAATAGGGT

CCTTGCAGATGTAATCGGGTGAAGATGG

GTTCATATTGGATTGGAGTGAGTCATAAT

CCACTGTGACTGGTGTCTTTAAAAGAAAA _M

GGACACACGGAAATTCAGAGACAGAAAG S

ACCCACAGGGAGAATGCCATGTGATGAC

AGAGGCAGAGACTGGAGTGATGGGTCTA

TAGCCAACGGACACCAAAGACTCTCATC

CACCAGAAGCTGGAAGAGGCAAGAAGGT

ATGGTCTCCTAGAGCTTTCAGATGGAAC

AAGTCCCTCCTGATACCTTGATTTTGGAC

TGCTGGCCTCCAGAACAGTTAGAGAATA

CATTCTTGTTATΠTAAGTCACCCAGTΠT

TAGTATGGCAGGCACAGGAAACTAATAT

AGACCCTAAGAAGTCTTCCAGCTCTGCT

ATTCTTAACTTACTGGGACACAGAAAGCC

CTGTCTCCTCATTTGACATTATCCACCTA

CTTTCACTACCTTGATCTCTGAAGGTGCT

TTAGACCTGCCTGTCCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2410641 8 20265917 TGAAGATGGGTTCATATTGGATTGGAGT A/C AGGAAGGAAAGGAAGTCAGGTGGAAGA SEQ_0354

GAGTCATAATCCACTGTGACTGGTGTCTT GGAGGTGGGGTGTTGGAAACAGAGGTT

TAAAAGAAAAGGACACACGGAAATTCAG GAAGTGGCAGAAGCAGCACTTCCTGAGT

AGACAGAAAGACCCACAGGGAGAATGCC CTGGAAAGGTGGGAGGGAATGAAGAGC

ATGTGATGACAGAGGCAGAGACTGGAGT CTCAGGGCTGAGGGAGAAGGGCCTGCT

GATGGGTCTATAGCCAACGGACACCAAA TCCTTTGTGAGGCCACTCAGAGGCAGTG

GACTCTCATCCACCAGAAGCTGGAAGAG GGTCACCGAGGCTCGGTCATAAGTGACT

GCAAGAAGGTATGGTCTCCTAGAGCTTT GAGGTGAT

CAGATGGAACAAGTCCCTCCTGATACCT

TGATTTTGGACTGCTGGCCTCCAGAACA

GTTAGAGAATACATTCTTGTTATTTTAAGT

CACCCAGTTΠTAGTATGGCAGGCACAG

GAAACTAATATAGACCCTAAGAAGTCTTC

CAGCTCTGCTATTCTTAACTTACTGGGAC

ACAGAAAGCCCTGTCTCCTCATTTGACAT

TATCCACCTACTTTCACTACCTTGATCTC

TGAAGGTGCTTTAGACCTGCCTGTCCCC K>

TAAAAAGCAAAGAGGGA 2 rs12549080 8 20266185 CAGCACTTCCTGAGTCTGGAAAGGTGGG C/T GAGGAATCAGGTCTGAGGATTTGGGGTT SEQ_0355

AGGGAATGAAGAGCCTCAGGGCTGAGG CTTTCGCCCTGTATTTGTCAGTGAACTTA

GAGAAGGGCCTGCTTCCTTTGTGAGGCC TAGGGCAAAATGTTTAATAAGCAATTTGT

ACTCAGAGGCAGTGGGTCACCGAGGCT CTCTGGAAGGAGAGGAAGGAACTAATGT

CGGTCATAAGTGACTGAGGTGATAAGTG TTTGAATTTCAGATGAGATTCTTTCAAGTT

GGTCAGTTAAGCAACAATCGAGGTCTGG CTTTCCTTCGATGAGAAAATAAACAAAGA

GCGCCTTGTCATTTGGAGAGGGCTTAGG TGAATAGTTATCTCTGCCCATATGGTC

ΓGC

Supplementary Table 3

SNP Chr Position 5¹ Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS10503678 8 20266438 ACTTATAGGGCAAAATGTTTAATAAGCAA A/G A N N IACAAATAAAAAACTTTACTCCTGA SEQ_0356

TTTGTCTCTGGAAGGAGAGGAAGGAACT GAGTAACTATGGTAGTTACCAAGAACCC AATGTΠTGAATTTCAGATGAGATTCTTTC CAGCTTGCAGATGAGACTCAGAGCTGTG AAGTTCTTTCCTTCGATGAGAAAATAAAC AATTAGCTCAGTCAGAGGACTTGCCAGA AAAGATGAATAGTTATCTCTGCCCATATG GATTCATCCAGTGATGAAGCTGACTAACT GTCTAGAAGCGGGTATAGAAGGCAGGAC TCAAAGACCAGACTCAGCCAGCAGCGGT CTTCTGTAGGCTGGACACTGTGCTGGA GGCTCACGCCTGTAATCCCAGCACTTTG GGAAGCTGAGGTGGGCGGATCACCTGA GGTCAGGAGTTCAAGACCAGCCTGGCCA ACATGGTGAAACCCCGTCTCTACCAAAA GCAGCAAAAATTAGCTGGTCATGGTGGA GCATGTCTGCAGTCCCAGCTACTGAGGA GGCTGAGGTGGGAGAATTGTTTGAACCA GGGAGGTGGAGGTTGCAGTGAGCAAGA TTGCGTTACTGCACTCCAGCTTGGGCGA CAGAGCAAGAGCCTGCCTCAAAAAACAA AAACAAAACAACAGAAAACCAGGCTCTTA K* GCATTCAATATAGCCAATTCTC K* rs4922167 20267105 GCGGTGGCTCACGCCTGTAATCCCAGCA G/T CCTCAGTΠTCTCAAAGAGAGCTGTTCTC SEQ_0357 CTTTGGGAAGCTGAGGTGGGCGGATCAC TTGGCCAGGCGCATTGGCTCATGCCTGT CTGAGGTCAGGAGTTCAAGACCAGCCTG AATCCCAGCACTTTGGGAAGCTAAGGTG GCCAACATGGTGAAACCCCGTCTCTACC GGCGGATCATCTGAGGTCAGGAGTTCAA AAAAGCAGCAAAAATTAGCTGGTCATGG GACCAGCCTGGCCAACATGGTGAAACCC TGGAGCATGTCTGCAGTCCCAGCTACTG TGTCTTTACTAAAAATACAAAATTAGCCG AGGAGGCTGAGGTGGGAGAATTGTTTGA GGCGTGGTGACACATGCCTAATCCCAGC ACCAGGGAGGTGGAGGTTGCAGTGAGC TACTCAGGAGGCTGAGGCAGGAGAATCG AAGATTGCGTTACTGCACTCCAGCTTGG CTTGAACCCAGGAGGCGGAGTTTGCAGT GCGACAGAGCAAGAGCCTGCCTCAAAAA GAGTCGAGATCGAGCCATTGCCCTCCAG ACAAAAACAAAACAACAGAAAACCAGGC CCTGGGCAACAAGAGTGAAACTCCATCT TCTTAGCATTCAATATAGCCAATTCTCCC CAAAAAGAAAGAAAAGAAAGAAAGCTGTT I I I I I I GTCTCCATCTTTCCTCTTCTCTCA CTTTTAATCCTTTAAATCTTTTACAGCCAG AACTCGTATGTATTCATTTAGAGCGCTCA GTGCAGTGGCTCACACCTGCAATCCCAG CTTGCCATTCTCACCAGCACAGAAAAATT CTATTCAGGAGATTGAGGCAGGAGAACT TGAAGAATCATAAAAGGTCAGAATAAGAA GTTTGAGGCCAGGAATTTGAGACCAGCC GGAACTTGCCCACCTTTTCATTTTAGGAA TGCTGGGCCACATAGCCAGATCCAGTCT TGAAGAAACTCATTTCTT CAAACAAAACAAAACCCCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4922172 8 20267464 CAAAATTAGCCGGGCGTGGTGACACATG C/T TTACAGCCAGGTGCAGTGGCTCACACCT SEQ 0358

CCTAATCCCAGCTACTCAGGAGGCTGAG GCAATCCCAGCTATTCAGGAGATTGAGG GCAGGAGAATCGCTTGAACCCAGGAGG CAGGAGAACTGTTTGAGGCCAGGAATTT CGGAGTTTGCAGTGAGTCGAGATCGAGC GAGACCAGCCTGCTGGGCCACATAGCCA CATTGCCCTCCAGCCTGGGCAACAAGAG GATCCAGTCTCAAACAAAACAAAACCCCA TGAAACTCCATCTCAAAAAGAAAGAAAAG CAAATGATTACATCTCTGAAGTGTCTGAT AAAGAAAGCTGTTCTTTTAATCCTTTAAAT TCTCCAAAGACATAGAGAGAGGAAATGA CT CC rs13278066 8 20268014 TTACAATTTCTAG G AATCAGATG AAATTC A/G GGGAAGCCAGGCACAATTTCCCATCGTT SEQJ3359

TTTCAAGTCCTTTCCTTTGATGAGAAAAT C I I I I I CAGAGAAAAATTTCCAATTTTATT AAACAAAGATGAATAGTTATCTCTGCCTA TTTTGGCAI I I I I I I GAGATATTGCTTATA CGTGGTTGAGAAAAGGATACAGAAGACA GATAATAAATGGTACCCATAATATGCCAT ATGTCTAGAAATGGAGCCCATCAAGGAG GTAATGGTAGTACAACATTAAAGGACCAT TTGAGCACATTCACTCATTTGCTTACAAA CTACTGAGTTTTGACTTATGTATACAACT GCCTGATGATTTAGAAATCATTAATGAG ATAAAACTATCACAAGTGAGATGCCAGAC

AGTTTCATCGTCCACCCCCAAAGACTTCC

TAGTGTCCCTTTAGAATCTTTCTCTCCCT K*

ATAATCCCATCCCCAGGCAACCACTGAT

GTGCTTTCTGTCACTTCAGATTACTTTAG

TTTGCTTTCTTA I I I l IAG I I I I IAGTCGA

GACAGGGTCTCACTTTGTCACCCAGGCT

GGAGTGCAGTAGCATGATCACGGCTCAC

AGCAGCCTCGACCTCCTGGGTTCGAGCA

ACCCTGCCACTTCAGCCTCTAGTAGCTG

GAAATACAGGTCCGCACCACCACCCCTG

GCTAATTAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12550451 8 20268079 GATGAATAGTTATCTCTGCCTACGTGGTT C/T AI I I I I I I GAGATATTGCTTATAGATAATA SEQ_0360

GAGAAAAGGATACAGAAGACAATGTCTA AATGGTACCCATAATATGCCATGTAATGG

GAAATGGAGCCCATCAAGGAGTTGAGCA TAGTACAACATTAAAGGACCATCTACTGA

CATTCACTCATTTGCTTACAAAGCCTGAT GTΠTGACTTATGTATACAACTATAAAACT

GATTTAGAAATCATTAATGAGAGGGAAGC ATCACAAGTGAGATGCCAGACAGTTTCAT

CAGGCACAATTTCCCATCGTTC I I I I I CA CGTCCACCCCCAAAGACTTCCTAGTGTC

GAGAAAAATTTCCAATTTTA I I I I I I GG CCTTTAGAATCTTTCTCTCCCTATAATCC

CATCCCCAGGCAACCACTGATGTGCTTT

CTGTCACTTCAGATTACTTTAGTTTGCTTT

CTTA I I I I IAG I I I I I AGTCGAGACAGGG

TCTCACTTTGTCACCCAGGCTGGAGTGC

AGTAGCATGATCACGGCTCACAGCAGCC

TCGACCTCCTGGGTTCGAGCAACCCTGC

CACTTCAGCCTCTAGTAGCTGGAAATACA

GGTCCGCACCACCACCCCTGGCTAATTA

AAACAAA I I I I I I GGCTGGGTGCGGTGG

GTCACACCTGTAATCCCAGTACTTTGGG ^

AGGTTAAGGCGG S

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6985844 8 20268359 TTCACTCATTTGCTTACAAAGCCTGATGA GfT TCGAGACAGGGTCTCACTTTGTCACCCA SEQ_0361

TTTAGAAATCATTAATGAGAGGGAAGCCA GGCTGGAGTGCAGTAGCATGATCACGGC

GGCACAATTTCCCATCGTTC I I I I I CAGA TCACAGCAGCCTCGACCTCCTGGGTTCG

GAAAAATTTCCAATTTTA I I I I I I GGCATT AGCAACCCTGCCACTTCAGCCTCTAGTA

I M M GAGATATTGCTTATAGATAATAAAT GCTGGAAATACAGGTCCGCACCACCACC

GGTACCCATAATATGCCATGTAATGGTAG CCTGGCTAATTAAAACAAA I I M I I GGCT

TACAACATTAAAGGACCATCTACTGAGTT GGGTGCGGTGGGTCACACCTGTAATCCC

TTGACTTATGTATACAACTATAAAACTATC AGTACTTTGGGAGGTTAAGGCGGGGGG

ACAAGTGAGATGCCAGACAGTTTCATCG ATCATTTGGGGTCGGGAGCTCGAGACCA

TCCACCCCCAAAGACTTCCTAGTGTCCC GCTTGGCCGACATGGTGAAACCCCGTCT

TTTAGAATCTTTCTCTCCCTATAATCCCAT CTACTAAAAAAATACAAAAATTAGCCAGG

CCCCAGGCAACCACTGATGTGCTTTCTG TGTAGTGGCAGACGCCTGTAATCCCAGC

TCACTTCAGATTACTTTAGTTTGCTTTCTT TACCCAGGAGGCTGAGGCACGAGAATTG

A I I I I IAG I I I I I A CTTGAACCCGGGAGGCGGAGGTTGCAG

TGAGCCAAAATTGTGCCACTCCACTCCA GCCTGGGCGACAGAGCAAGACACCATCT CAAAAGCAAGACACCTCTTTTGAATGAG _M

GTCTCATTATGTTGCGTAGGCTGGTCTTA S

AACTCCTGAGCTCAAATGATCCTCCCTTC TGGGCCTCCCAGTGTGCCACTGTACCTG GTCTAGTTTGCAATTCTCAGAGTΠTATA

TACATGAATCATATGATCTATATTC M i l l TGTTGCTGTTGTCTGGAGTATTTTACTCA GCATAGTCATTTTGAAATTTATTCCTGGT GGTGGCTATACTGACAGTTTATTCTGTTT TAGTTTAGAAGTGGCATTCCATTGTATGG ATATACCACAGTTAGTTTATACAGTTGTC TGTTGATGGACTTTGGGGCTGTCTTCAG GTTTACCATTAG I I I l I I M I I M I I I I GA

GATGGAGTCTCGCACTGTCACCCAGGCT

GGTGTGTAGTGGCTCAATCTCAGCTCAC

TGCAGCCTCCGCCTCCCGGGTTCAAGCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12543855 8 20268934 CCTGGGTTCGAGCAACCCTGCCACTTCA A/T TTCTCAGAGTTTTATATACATGAATCATAT SEQ_0362

GCCTCTAGTAGCTGGAAATACAGGTCCG GATCTATATTC I I I I I I GTTGCTGTTGTCT CACCACCACCCCTGGCTAATTAAAACAAA GGAGTATTTTACTCAGCATAGTCATTTTG I I I I I I GGCTGGGTGCGGTGGGTCACAC AAATTTATTCCTGGTGGTGGCTATACTGA CTGTAATCCCAGTACTTTGGGAGGTTAA CAGTTTATTCTGTTTTAGTTTAGAAGTGG GGCGGGGGGATCATTTGGGGTCGGGAG CATTCCATTGTATGGATATACCACAGTTA CTCGAGACCAGCTTGGCCGACATGGTGA GTTTATACAGTTGTCTGTTGATGGACTTT AACCCCGTCTCTACTAAAAAAATACAAAA GGGGCTGTCTTCAGGTTTACCATTAGTTT ATTAGCCAGGTGTAGTGGCAGACGCCTG I I I I I i I I I I I I I GAGATGGAGTCTCGCA TAATCCCAGCTACCCAGGAGGCTGAGGC CTGTCACCCAGGCTGGTGTGTAGTGGCT ACGAGAATTGCTTGAACCCGGGAGGCG CAATCTCAGCTCACTGCAGCCTCCGCCT GAGGTTGCAGTGAGCCAAAATTGTGCCA CCCGGGTTCAAGCGATTCTCCTGCCTCA CTCCACTCCAGCCTGGGCGACAGAGCAA GCCTCCTGGGTAGCTGGGATTACAGGCT GACACCATCTCAAAAGCAAGACACCTCTT TGTGCCACCATACTCGGCTAA I I I I I I GT TTGAATGAGGTCTCATTATGTTGCGTAGG A! I I I IAGTAGAGATGGGATTTCACCGTG CTGGTCTTAAACTCCTGAGCTCAAATGAT TTAACCAGGATGGTCTCAATCTCCTCAAC CCTCCCTTCTGGGCCTCCCAGTGTGCCA TTGTGATTCACTGGCCTTGACCTCCCAAA K* CTGTACCTGGTCTAGTTTGCA GTGCTGGGA rs4922173 20269870 AACCCTATATAAGCGATTAGGACAGAACT G/T CAAATAAAAACAAAACCCTAGACTTTΠT SEQ_0363 CCACATGCTGGACGAAAACAAAAGGATC ATTACTTAAATTTTAGAAATACCAAGTTAA AAGCAATAGGTCTTGGATGACTGGAGGG ACAAATTTAAGTTTCTTTATCACAAGACCT TTTCCAAAATTTACTTCCAGAGACAGGAA CTCAGAGCCTGTACCATGTTAATGATGTT CTGAAAAAACAGCCAAACAAAAATCATTA CACTATAAATTCTGAGAAGGTTATATTTA TTTCACAAAGCCTGTTTGAGAAAACCACT ATTTGAAATTTCCTCAGTGTATTGGACCA TGTTCCTCCGGATGATAGTAGATGTTTT CCAAACAGTTTTCCCCTCGTAAACTAGTG TTTCATAAGGACACACTTTGGGAAATGCT CTTTTAGGGACTTAATCATCTCTAAAGAA ATTTTAATATGAAGGAAAAGGAAAGTAGG TAATAAAATGTGAAAATTAAGGCAAAATT AGATTCAGATTCCCCCCACAACCTTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3892686 8 20275192 AGATTCAGATGTAGACCTGGCCTTCAGC A/C TGGGCTTGTTCTTCCCGCCCTCTGTCCA SEQ_0364

TCCCCCTTCCCACCTTCAAGTCCAGCCTT GTGGCAGTGACAGCAATCTGAGTCCTCT

CAAGTCTAGCCTCTTTCCACTTTCCCATC CCCAAGGACAGGTGGCAGCAACATGCCT

ATCCACAGGGAGGAGTTGGCTCAGCCAA GTGCTGGTGAACACTGGAATGAGAGCAG

GTGAGCTTTTCTAGGATAGCTTCATGAAA TGGGGATGTAGGAGGAGGAGATGAAAG

CAGCTGCCATTTGAGCGGGTTCTATTCT AGGAAGAGGAAAAGGAGGATGAGAAGG

GGGCATGTTTACAGGACGCTAGGGGGC AAGAGGAAGAGGAGGAGGGGAAGTGGG

CA GAAGGAGGAGGGGGAAGAGGAGGAGGA

GGAGAAGAAGGAAGGGAAGGAAGGGGA GGAGAAGGAAGAAAAGGAGAAGGAGGA GGAGGAGGAAATGGTGGAGGGGAAAGA GGAGGAGGGGAAAGAAGAGGAGGAGGA AGAAGAGGAGGAGGAAGAAGAGGAGGA GAGAAAGGAGGAGGAAGAAAAGGAGGA GGAGGGAAAGGAGGAGAAGGGAAAGGA GGAGGAGGGAAAGGAGGAGGAAGAGGA GGAGATGGAAAAGGAGCAGGAGGAGGA K* GGAAGAGAAGGAGGAGGAGGAGGGGGA AAAAGAGGAGGAGAGAAAGGAGGAGGA GGAGGAGGAGTCGGCGGCAGGAGGAGC CTTCCTAACACCTGGAGGGAATAGTGAG AGGGTTTGGCAGC rs 1038466 20277596 ATACAGTCAAGGCAGCAAAATGCAGTAC A/G ATCAACAGATATTACATATTCCC I I I I I GC SEQ_0365 AATATCAAGCTATGGCTTAAGGGAGAACT TTCCTTCCTTAGCTTGGGCATGTCTCTTT GAGGCTATAGAATAATGCTCACTATACTC CCCATTTTGGACCAG I I I I I I I I I GTTTGT AGTCGTTGTAATGTCTGTGTGCCTCTGC TTTTGCTTTTGTTTTG I I I I I ACAACTGAA CCCATTTACCTGAGGTCATACAGTCTCCC CAATGAAGGGCTTAGCTAAAATCCTAACC TATCCCTACAGCTCAGCATAGTGGCTGG ATTTGGATTCCAAATACGAGATTTTAGTC CGCCAAATTAGAGCTCAATCAATGTTGAA TAGTGCTAGTTGTTCCTGAGAAGAGACT TGAAAGCACTAGTGAAATAAAGCAAAGA CATGTGCATTTCATAGATATTATGCAGCA GTGTTGTAATTTCCTAAGTCTACTTCCTC CTCACTGCATATTAATT ATGTGAGAAAATGGGTGCTAATTATAGCC TGGTAGAGATGGAATAAGTTCAGTTCCAT ATGTGCTTAATGAGATACAGTGCCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4442161 8 20282398 TCTGTTCCCAACTGACCAGGCCATTTTCA A/G ATACAGTGAAGGAGCCTGAAGTAAGAAG SEQ_0366

TCTTCTCTGCCATTGCTGCTGGCCATACA GAACATGCTAGGTCCC I I I I I I I GTCAAT

GAACCTCTGAGCATCCTGGACCTTTCCC GGACTGCATCCTTGATACTTCTTGTTATA

TAGACTCTTTCAGGATGTCCTGCCCCTTT CTTCAGAATAAAAATTAGCGGGGCAGAA

ACATGCTATTTCTTCTTCCTGGAATTTCAT GCTGTCATCTGTGTGTGCACCTCAGGAA

CATTGTTATTTGATTGGGAAAAACCCCTC AGACCCACTGCTCCTTGATCGAGCCAAG

ATTCAAGATACAACTCCAATATGTTGACC CGGCCCTGGTGCAGCCCGTCTGTGAATC

TTGGGAAAACTTCTCTAATGGACCCAACT ATTTCTGATGAGTTCTAAATGGCTGCCTT

CTACAGGGCTTGATCTTCCCCTGGAGGT TTAGAACCATCCCAGCCTCCTTGCAGATT

CAGGGACCCTGTCATAGTCATCTATGTC TAGCTTGCATTGCTGTCTCCTGGCTGTG

CCTAGGTCTTAGCATCATGCCAGAGGCA GGGCCGGCATCCTCATTTCCAGGGCTGG

CAGTAGATGCCCAATTAATATCTGTTGAC AGCAGCCTGAAGCTTCCGGCTGTAAGAC

TGACTGGTGTGTCTGTCTGTGCAGGTGT AGCGAGTGTCCACCAGAGGCTGCTGCTG

ACATGTGGCGTTCTTGGGGTGAAGGAC CCATTCTCTGTCACTCCATCAATTCCCTT

TCA rs4922176 8 20282855 TAGCTTGCATTGCTGTCTCCTGGCTGTG A/G TGACAGATGGTCGTTTACTGACCTGCTG SEQ_0367

GGGCCGGCATCCTCATTTCCAGGGCTGG GTGACTTGGAGGTGGGGATGGGGTCCC K.

AGCAGCCTGAAGCTTCCGGCTGTAAGAC TGAAACTCGCAGATTTGTGTGAGAGACTT Se

AGCGAGTGTCCACCAGAGGCTGCTGCTG ATATCATATATACACACACACACACACAT

CCATTCTCTGTCACTCCATCAATTCCCTT ATATATATTTTCCCTCATAGTTGAGGTGC

TCATTCTGGAGCCCTGACTCCATCATCCA TACTAGAACCTAGGCTTTTCCCATATATA

TTGCCCCTTTCTGTTGCCTCCAGCTTCCA TATATATATATATTTATATATATATTTAT

A

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS9650601 8 20285218 TCATTGAGTGCTTATTATTATGTTTCAGG CfT CCTACCTTCAAATAGTTCACAGAATGCTT SEQ_0368

GTTGGGCTTATTCACCAATCTAGGAGTCA GTAAAGGAGAGAGACTAATAAACATTTCC TCCCTGATGACTTTCTGTCTCTCCAGGAT AAACCAAGGTGACAAAAGCTATGATAGA CAATCTGTCAATCGGGCTGAGAGATGCT GAAAGGTATAAAAGCACTATTCGAACACA TCCAAGATATGTGCTGTGCCTGGCCTTTT GATGAGGAAATAATTAAATTTGCTTCATT CTCCACTTCTTCTGCCTTGCCCAGCATCT TGAATGAGGCTTATCTCTTTGCTTGTATG CCAGTCCAGAΓΠTGAAATCACCTCACTT GTAAGCTCCTTAAGGACAAACTGTATT CCACTATTGCCCCAATGTAATGCATTCTC CATAGACAGGGATTCTTGAAGGGAGGAA ATCAGATCATGTTGGTTAATCACCTTGGT TAAAATTCTCCAGTGGTGTTTGTCCTATT GCAATTGGAATCAAATAGAAATAGAACTA GAAAATAAAATAGAACCATCCTTACCCAT GGCTTATGAGGGTGCATGTCACTTAGCC TCTGCCCACCTTTCTGGCCCCGTCTCCT GTTTCTCTCCCTGTCAGTCACTAAGTTCC ACCTCCCTGGCCTTCTCTCCTTTGCTTCA K* GCCTGAACCAAAGTTGGTTGCAACCTTT GAGCCTCTGCACTTGGTGTCTCTGCCAG GGATTCTCTTTCCAGTTGTTTATGCCATA AACTGTATGTTATCATTTTGGGATTTAGC TCAAAAGTCACCAACTTAGAGAAGTCTCC TATGACCATGCTATCAAATATTGGCCTCC TTGTCAATCTCTTTCTCATTACCTTGTΠT ATTTTCTTTATGGCACTTGTCTTATTCATT TATTTTGTTTCTCCCCATCCTCCTCCCTT CACTAGAATGTAAGTTCTAGGAAAGTGA GAGGGTGGTCACTTTTGCTTTCTGCCAC ACTGCCAGAGCCCAGAACAGTGTCTGGT GGACTCAATATTTGTTTAAATAAAAGAAT GCATGAATGGTAAAAAGACCACGTGACT GAATGTATCCAAGATGAATAAACATAGC

ΓS11204111 8 20285881 AATAAATCCATCTCTGTCAGCTCCATTCT GfT TTTTATTCTTTTAACTGAACAGCACACAG SEQ_0369

TTCTCTGACCAGCTGCAGCTGAGCCCAG GCATTCTCCTCTTAGCTACCTACCCCTTG AGTGAATGACCACGCATGTCTGAGGTTC TGAATAGTCGCGTGGCAGCCGAGAGCC CTGCCAGTGGGGAGAGCACGAGAAGAT GCAGCCTGGAGACAGCCACCTCCGGGC AACAGCAATCCTTCCTTCTTCCTAGCGTG CGCACGGTCTCCTGGTTCTCACAGGCAC ACGGCTTTAGTGTCGCTCATACCTCTTCA TGGGCCCTGAGCTGAAGGGCAGGCGGG CAGGGATGGTTATTACCAGCCTTATGGG AGTCTGCGTGCCCATGCTGGTGTGGACT TC GATGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4922184 8 20295408 TCAGAAAAACCACCTATAAGTTGACCCCA A/C TGTGGCATAAGAATGGAAGAGGAATAGT SEQ_0370

ATAGTCCAATATTCTTTTCAAATGAGGAA AAAAATAAATGTGGGGAATTATTTAGGCA

AAGTGGATGAAACTΠTAAATGTACTATT ATGGGAGATATTGATGGCTTCTAGGAAC

TGTCTTCTCACTATATTGTAACTAAACCA CAAGATACACGCAGTCCTAAGTTCAAGT

AAGCCAGGAATACAGAGAAAGCATTTTAT GGCAGCTCCACAGCTTATCAGCTGTAAA

ATATTATTGTTGAATTTAACAAAGAAATTA ACCTTGGGCAGGTTATTGAGCCTTAGTTT

GGTTGAAACTCAATGACTTTCTGGG CTCCATCTGTAAAATGGAAGATAATCACA

GCACGTATTTGTAGGGTATCCAGAAGAA

TGAATTAAGAGAATGGATGCAAAGCACA

CAGCACATGGTAAGAACTCAGTAAGTGT

TAAGTATGATTATTATGTTTAATTCCTGAC

CTAGAAGTTGAATG I I I I ! IATTTCAAATA

TGTGAAACAATATAGCAGTCACTTGAAGA

GATCACACACCTTACACTGGTA

W

O O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2200330 8 20299494 TTAGCAGCTACTGAAAATATATAAGTAAT A/G GACTACAACGAATTTAAAAGTTTCTGCAC SEQ_0371

TTATGGCTACACTTCAACAAGTTMGACA AGCAAAGAAAACAACCAAATGAAAAGGT TCTCAATCAAATCAGTTATACATATACCG AATGTATGGAATGGAAGAAAATACTTGCA GTTCAACTTCTTTGAAAAATAATATGGCA AACCACATGTCTAATAAGGGGTTAACATC ATAAATTTATCAAGAGTAATAAAATAAAAG CAAAATGTATAAGGAATTCAAACAACTCA TTTACATGCTTTGATCAATAGTGTGCTGG ACAGCAAATAATAATAATAATAACCCAAA TAAGCCAGCTCTCCATAAACTAAACAAAA TTTTTAAATGAGCAAAGAAGACATACAAA ATTAGATTTGTAGCATTTGTTAATTTGTGT TGGCCAAGAGATATA I I I I I IAAAATGCT GACATAAATATTTCTACCTCTCACAACTT CATAATCACTAATCATCGGGGAAAACCAC ATTTTAAGGGAACTTTCTGAATACAGAAT AATGAGATATCACCTTATACCTGTTAGGA TGGCAACAGATTTGCAAAATGAGATCTCA TGGTTATATCAAAAAGTCAAAAGATAACA CAAGCTGGTATGACCTAGCGCCAACATA AGTGTTGGGGAGGATACAGGGAAAAGG CACTGCCTTTGATCCTCCTCCTAGACATT GAGCCTTTGTTCACTGTTAGTGGAAATAT AATCCCGAAGAAATAAAATGA I I I I I CTG AAATAGTACATTCATTATGCAAAACAGTT CATCTATTGAGATGGTCGTAAGATCTTTA TAGAGGTTGCTCAAAAAATTAAAAATAAA TTCTTCACTCTGTTAATGTGGTGTATGAC AGTACTCTTTGATCCAGCATCCCACTTCT ACTTACTGACTTGCATATGTTGAAACTTT GACATATCGAAAGGAAATGAAATCATGAT O TTTGCATCCCAGGAATAAATGGCACTTAC CTTGAAGAGTTAGCTGCACTCCCATGTTC TTAATCATATTGTACGATTCTTTTAATGTG TCTGCAGTATTACTCATAATAGCTAAAAT CTGTAGAGTTCAGTATGCTAGTATTTTGT ATGAAAACAAATTGCGTCCATTGACAGAT TGAGAAGTTTTGCATCTATGTTCATCAAT GAATGAATGAAAGAAATGTAATACATATA GATATTGGCCTGTAATTTTCTTTCCTGGT ACTATATAATAGAATATTATTCAGTCTTAA AGTACCCTTGTCTGGCTCTGGTATCAGG AAAAAGAAAATTCTGCCATTTGCAACAAC GTAATGCTGGGCTCATAAGATGAATTTG ATGGATGAACCTGGAAGACATTAAGTTAA GAAGTGTTCCCTCCTTTTCAA I I I I I GGA GTGAAATAAGCCAGACACAGGAAGATAA AGAGTTTGAGAAGGACTGGTATTAATTCT ATATTGAAAAATATCATTTACATGCAATAT TCTTTAAATGCTTGGTAGAATTCACCAGT CTAAAAAGGTCAAACTCATAAAAGCAGAG GAAGCCATCTGTTCCTGGGTCTTTCTTTT AGTAGTATGGCAGTTACCAGGGGCAGTG TTGGAAGG I I I I I GATTACTGATTCAATC GGTAGGGGAAATAAGATGTTACTGAAAG TTCTTAGTCATTAATAGTCTGTTCAAATG GGCACAAAATTCCAGTTATAAGAGGAAT CTCTGTTTCTTCATGATTCAGTCTTGGTA GAGTTATGGAGCTATAATATATAACATGT GGTTACATGAATTTATTCATTTCCTCTAG TGACTACAGTTAATAATACTATATTGTATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4922185 8 20305040 CAGGGCAGAGGGCCTGAGAGAAGAGGG G/T TGTTGCATTCTGAGTTGCATTCTGTTCAT

TCAGATTAGGACTCTGGAGGGCTACAGA TTGCCCAACAGTGCTCATCCCGATGTGT ATCCCACTCAAGGCTTCCGCAGAGCACT GTTTACATACTCACTTGTTTACATATGATC GATGGGTGCAGATATGTGAGCACATTAC ACTTATGTCTTCTCTGTGACTTCCCACCT TCAAGGGCAGAGAAAAATACCACCCCTC GATAGCAAACTCCATGAAGGCAGACACA A I I I I I IAAAATTATTATACTTTAAATTCTG GTGCCTGTTTTATTGCTTGGTGTTTGAAC GGTTACATGTACAGAACGTGCAGTTCTG AGCACCTGTTACTATGCTAGCACATACCA TTACGTAGGTATACACGTGCCATGGTGG TCCAATAGATGGTACCTGTTGTTATCATA TTTGCTGCACCCATCAACCTGTCACCTAC GCAGGGAGTCAGTAAAGGAATAAAATTA ATTAGGTATTTCTCCTAATGTTGTCCCTC AATTAACAGATGAACTAGTAATTTTGCAG CCCTAGCCCCCCACTCCCCGCAGGCCC ATGAAGAAACTGAGGTTCAGATAAACTCA CAGTGTGTGATGTTCCCCTCCCTGTGTC CTCACTAACCTGAGGCCACATGACTAATT CATGTGTTCTCATTATTCACCTCCCACTT GAGGTTCCA ATTGGTGAAAACATGTGGTGTTTGGTTTT TTGATCTTGTGATAGTTTGCTGAGAATGA TGGTTTCCAGCTTCATCCATATCCCTGCA AAGGACATGAACTCATCC I I I I I IATGGC

O TGCATAGTATTCCATGATGTATATGTGCC K* ACA I I I I I I IAATCCAGTCTGTCATTGATG GACATTTGGGTTGGTTCCAAGTCTTTGCT ATTGTGAATAGTGCCACAATAAACATATG GGTGCATGCGTCTTTATTGTAGAATGATT TATAATCCTTTGGGTATATGCCCAGTAAT GGGATTGCTAGGTCAAATCGTATTTCTAG TTCTAGAACCTTGAGGAATTGCCACACTG TCTTACACAATGGTTGAACTAATTTACAC TCCCACCAACAGTGTAAAAGTGTTCCTAT TATTCCACAACCTCTCCAGCATCTGTTGT TTCCCGTATCTTGAGTTGA I I I I I GTGTA AGGTGTGAGGAAGGGGTCCAGTTTCAGT TTTCTGCATTTGGCTAGCCAGTTTTCTCA ACACCATTTATTAAATAGGGTTTCTTTTCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs900951 8 20308179 TGGCATGGTAGGGGGACAGCAGTGGCC C/T ACCCCTGCCACAAAGAAGTGCTCAAAGG SEQ_0373

CCCAGTCTGCCAGGCCAGCATCACAGAT AACAGATGTCAATTGTTTATC I I I I I I I I I

GGGCTCTCCACAGCACAGGGAGTGTCCA TGTTTGTTTG I I I I I I I I AAGACAGGGTCT

AGCCTTGCCAGGCTGTGGTTCCCTCCTC TGCTTTGTTGCCCAGGCTGGAGTGCCTG

CTCTCTGCTGGCGTTTCCTCTGGTATTTA GCATGATCATAGCTCACTGACACCTCGA

TTCACTCACATAGCCTATAGAGTTAAAAG ACTCCTGGGCTCAAGCAATCCTCTTGCTT

AGGTTTGTTTCTTTTCAGGCTGTTGAGTG CAGCCTCTCCAGTAGCTGGGACTACAGG

CAGCCAGGGTAATTTAGTAGAAAAATGTC TGCATGCCACCACACCTGGCTAATΠTAT

ATGCTAATGCAATTCAAAGTTCAAATGAT TTTCTGTAGAGACAGGGTCTGGCTGTGT

CTTTCATΠTGAGGGAAAGAAGAATGTGT TACCCAGGCTGGTCTCGAGCTCCTGGCT

GTGCAGTTGGAATGTTAAAACTCACTACT TCAAATGATCTCCCCACTTCAGCCTCCCA

TGCCCTGCAATTCAAATAGAAATATGAGC AAGCCCTTGGATTACAGGTGTGAACCAC

TGCAGGGGCTACATAAGTCACATGAAGT CACACCAGGCCAGCTGTTTATATCTCAAT

ACTGTGAGTGAAATGCGCAAAATGAATAA ATG

AAATGATCCGGAAGCCGTTTATTAGCATT GCTGGGGGCCAGCACCAAACAAGAACT

GTAGCCGTCAGAAGCTGCGTGGAGAAG W

GAGTGTTTGCATAAAATTACAATAATCCT S

GAAATAATGAGGAAGTAAGTGATCAGTG AGGTCCTTCTTACCAATGTCTCGAAAGCC GCCCTCAGACCCCCGGAAAGCTGTACCC TTTCCCAGCTCACATGCCCTTCCCTCCTC TATCTGCCTGGCTTGGCTGCACTTGCAG GTGGGTGGGTGGCGGTGAAGCTTGGGG AGAGGCTGCATGTGCCCCCGCACTGCCT GCTGTCTTGGAGTTTGAGGGGAGATAGA AAGATGGATGGAGAAGTTGTGGTCACTG GGCTTAGTTCAGGCCACCCACAAGAAGA CAAGAGAGTGTGGTTGGCACCTGGGCA

GGGGAGGCAGCTCCCCAACCCTCACTG

GAAGTCAGGTCTGTCCTTGGAGAGTTCA

TCCTCCTTCCACTCCTCTTCTGGTTTCTT rs4921710 8 20308883 TGCCCAAGTTTCTTTCTTTAGTCTTAAAAA C/G TAGGAAGAAGTAATTGAGGTTAAATGATC SEQ_0374

TCAAATTCTGTTTACCTCTAAGAGATCAT ATAAGGGTGGGACCCTGATTTGTAGGCA

CTCGGGTCACCATCTACACAACCTGCTTT TGTGAAGGAGAGGTCCTGTGAGCACACA

GATGGTATTATTACATTCTCTATCGTTGTT GTGGGTGAGATGCTGGCCCCCTACAAGC

ATGAAAAAACTAGGTTCCCCCTGAAAAAA CAAGAAAAGAGGCCTCAGAATAAAATCTA

AATTCCCATGTCAAAGCCCCAATCCCTGA CCTTGCTGGCACCTTGATCGTGGACTGA

TGTGACTGTATTTGAAGACAGGGT CTTCCTAGCCTCCAGAACTGTAAGAAATA

A

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs885437 8 20312188 TTGAATTC I I I I I I GTTTTGTTTTGTAGAG G/T CACTGCTGGAGTCTGTATCTTCCCCAAG SEQ_0375

ACAGTATCTTACTCTATTGTCCAGGCTGG ACTTGATTCTCCACTTTCTTCTCCCGTGT

TCTTGAACTCCTGGCCTCAAGTGATTCTC TCAGGCAACATTTATTCTAGAAAGGCTCT

ATGTCTTGACCTCTCACAGTGCTGGGATT GGCTTTAAAGACAAAGGAGAAGAAAAAC

ACAGCTGCAAGCCACCACACCTGGTCAA TCCCAGTAAAACAGAGATCATCAAAGCA

AAGCTATTGAG I l I I I I GAGAGTGAACAG GAACCATTTCTAAGTGAAATGATTTCTTC

ACAAGATTCCATTCACG I I I I I I ATACTAT CTACCCAAACTTTACCACAAGGCCCCATT

CCACAGTCCCTAACATTATGCCTTACATG AAAGAGCTGCAGAGCCCCAGCACGGAA

TGGTCAGCAATTATCAAATATTTGTTGAT GCACTATAGATTACAAGAATCCAGAAATC

TGATTAATGAACTGCCAAAGCCATTTTGA AGGAACAGAGAGTCACAATTCCCACTGG

T AGTTTGCTGTGCATTTC I I I I I GCAAAGC

ATCCAAAGCAGATTGAAATCCTGGCTGA

GGAGCTCGCAGAAAGAAAGAGCTAAGGC

AAAGGGCAAAGGCATTAAATAATATATAG

ATTTTCACAAAAGATCATTTCTGCTTAAAT

AGCTGACTGGTCACGTTGGTGACCAGGT

TTGGCAAGGAAGGAGGCTGGTGCTGCT _W

GACAGTGGAGAGCACGGAGCTGATGCA g

ATCGACGGGGACACAGTGACCGTCATTT

AAATGCCCCAAATTGAAAGTCCAAATTTC

TAGGAGGTATAACGTGAAGACGATTTATC

CTAGTTTTATTAACTCTCATAAAAGCACTT

CTAGCTGCTCTCTGATACAATCATCTATC

CAGTGGTATAAGTTAAGATATAAGTTGAG

CAGTATAAGTTAAAATTCCAGACAACCCT

ATACTACCCCAGGAGTGGTTTCCCCACT

TTCAAGGTTTCAGAAACCAGCTCTTCCAT

GAGAGTCTCTACAATAACAAAGGGCTCT

ATTCTCACCCTTCTTCAAGAACACCATCG

CCACCAACCCTCCAGTTCTGGTACATTTC

CACCGAATGGAACACCCGCTGGTTTTAG

GGAGAGGAGGACTAACAACAGCAACTAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4921712 8 20314771 ACAGCATGTGGTGGCTGCA I I I I I GTGT G/T GTTCCACGGTTGTCAAAGTGTGGTCCCC SEQ_0376

CTGTTTCCTTGTTGAGCATGGCTGGAAA AAACCAGCAGCATCAACTTCACCTGAAAA GTGAGATCAGCTAGAACCATTGACCAAA TGTGTTAGAATAGTCAATTATCAGGCCCC GTGCTTATGCATGGG I I I I I CAGCATGGT ACCTCACAACCATTGAATCAAACATCTTG

GACCTCAAGGTGGTCAGAGCTTTTAAAT GGTGGGACCCAGCAATTTGTATTTAACC

GGGAGCTCGGAGCTCCCAGAGTGAAAAT AAGCCCATAAGGTGATTCTGATGTGTGTA

TCCAAGAGACGGTAAGCATAACCTGATA AGGGTTAAAGAAGCCCTGGGGTTGGTTC

CTCTCTCAAGGCTGGGTCAGGAAACAAC CTTTCAGCCGACTTTCTGTGATTCTAACT

CACAACACCATTTCTGCCCTATATTACTG ACAGAAGCACCCTTTCATGCCACATGAC

GTGACGCAATCCCAGAACCACCCTCTAG CAGAACTAATAGCCAATTAATTGAAAAAA

TCAAGGGGAAGGGACAAAGACCCCACCT TTAATTAAAATTAAGAAATGCTACTTACAT

GTGGATGGGAAGAGTGTCAAAGCAATTG TTGTGAAACTTTTAATTTTAACGAAAGGA

TGGTCACATGTAATCTATCATGAGCGTTA AGTCAATCTTTCGATGTAGGGTCAAGGC

TATTATTTGTΠTGACAGCAGGAGGCAAT CTTTCTTTGAGTGTGAGTCTGCTGGTTGG

GGGAAGATCCTGATGCTAACTTCGGCTC ATTTCTATGACAGC I I I I I I GCATAACCC

TCCTGTTAGCCCACTGTGTGTACATGAG ATATCTTTAATGCATGATCTAAGA

GGAACCTCTTTAAATCTCCACACCTCAGA

ACTTCTGCAGTGATGGATG O rs962438 20317569 AAATAGGTGGTCCTCACGTGCAGCTGCT C/T GAAGCGGGCTATGTTTACCCATAGTTCAT SEQ_0377 CAAATAGGCCACTGAAGGCTCAGACCCC AJCTGGCATCTTTTATAATTGGTGGTTAT TTCTCTCTCTTCCTGCTTCATCATCTTTCA TTATTTA I I I I IAATATTACCCTTGCTTAA TATCTTTAGCTTTTATTTTCCATTGCAGG AAGCCCCACCTGCTAACTTCTGCTTTATC GTGGCTGCTGTGCCTTCAGGCATCGGAT TCATCATCTAGTTCTGGGTTACATAGACA CACGTTCCAGGTGGTAAGAAGGGAGAG CCCTTGCCTGGGATAGAGTTGGAAATTG GGCAAATTGGCAGAGCAGATGACACTGA AGTG I I I I IACTTGGGTGCACTGCCACC GCCTGTTCCTTTCCT CTCAAACAGGTTTGAGATTCTGTCAAAGA .GAAGACAACAACAGATACTGAGCAGGCA ATTAATCGTCTGCCATAATGCTTAATTCA AACTTGTGTATTATTCTAAATTGCACCAC TTGGCTTTATATTTAAAGGCAACAAGCT rs 12547668 20318368 I I I I I C I I I I I I ATTTCCCACGGGCCCCC CfT ATTTAATTCTTTAATGTATGTATTAAATAC SEQ_0378 AAATGGTACTGAACACAACATAGAGGAAT CTATTCTACGCTAGACAAAAATACAACTG ATTACATACTTACTGTTTGGTTCATAGGA TCCTAGATTCTGTATTCTATTGACCTAGC AATGGTATCATGGTGGTAGTTGAGCTAG AGTATAGACAGGGTCAAATACCAACAAG ATATGAATGTGGAACAGTATGAAGGCTG ATMTTTTGCAAAAAATTATAGTTCTAGAC TGTTTCTGGGTCTAAGAGTCTGGGTGAC TTCCTCTAGATTGAACACTTTCCATCTGC AGAGTAGCGAAAGATAAAGTTAGTTCATT CTGGCACATGGACAGAAGCACACAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs17491195 8 20319492 GCAGCAGCTGTGTCTGGCAGGGGTCGG C/T TGTTGAAGGCAGACCTTCCACAAGCTGA SEQ_0379

AGGCTCCCTTTCCATACACTACCTCTGG GCTGTTCTCAGCTATCCAGTGTCTTGACA

CTAATGGTCCGATCCCAGCACTGACAGC TGGGAGGAACACTCGGTGATTTGAGCGT

TCGGTTCATACATTCTC TCTTTGGGTGCCTGC rs 13255879 8 20320530 CAGCACTTTGGGAAGTCAAGGAGGGAAG C/G AAATTCAAATATTGAAGTCCTGTCCCTCA SEQ_0380

ATCGCTTGAGGCCAGGAGTTTGAGACCA AGATGATGGTATTAAGAGGTGCAGACTC

GCCTGGGCAACATAATGAGACCCTGTCT TGGGAGATGATTAGATCATGGAGGCAGA

CTACAAAAAATAATAAAAAATGTTAGCTG GACCTCATGAATGGGATTAGTGTCCTTAT

AGCATGGTGGTGTACAGAATGTTTAGTC GAAAGGCTTCAGAGAGACCCCTGGCCCC

CCAGCTACTCAGGAGGCCGAGGCAGGA TTCCGGCATGTGGGGACATAGTAAGAAG

GGATCATTTGAGCTCAGGAATTTGAGACT ATGTCATCTATGAGGACATGAGCCCTCA

GCAGTGAGCTATGATCGCACCAATGCAC CCAGACGCCCAGTCTGCTGATGCCTGGA

TGCAGTCTGGGTGACAGAGCAAGAACCT TCTTGGACTTCCCATCCTCCAGAACTGTG

GCCTCTTAAAAAAACCTTATTGAATTTCT AGAATACAA I I I I I GTTGTTTACAAGTCA

CTAGAATATAAGTATGTTGATGCTGGCTT CCCAGTTGAGAGTACTTTGTAATAGCAG

GGATCAGGGCGTCCTTGGTGCCTGGCA CCTGAACAGACTAAGACACATGCTGATT

CTTACTACATGTGCAGCAAATATTTACTG CCTATTTTTTCATAAGAAACCCGGAACAC _W

AATGAATTGCTGAATGAACTTGAGAAGG GGAGCTATTAAGGGTGTAAATGGCAGAA °,

CTCAGGCACTGCACTTTTGCATATACTTC TTAGGATTTCAAGTCATGGTTGGGTCTGT

CATTTTCTCCTTCACGTCTAATTGTGTTTA ACAAGGTTAGGGCTCTTTCTTCCTCTTGC

TATGAGGAAACAATAGTGCTGTGGTCTG CTCAGCTTTTCCGTCTTCTCAACCCTGGC

AATGTTTATGTCTCCACC TTCTCACCCAAGGCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4922188 8 203210₄6 ATGAGGAAACAATAGTGCTGTGGTCTGA A/G TAAGACCAGCGGTTCCCAACC I I I I I GG SEQ_0381

ATGTTTATGTCTCCACCGAAATTCAAATA CACCAGGGACTGGTTTTGTGGAAGACAG TTGAAGTCCTGTCCCTCAAGATGATGGTA I I I I I CCATGGATGGGGGGTGGGGGATG TTAAGAGGTGCAGACTCTGGGAGATGAT GTTTTGGGATGAAACTGTTCCAACTCAGA TAGATCATGGAGGCAGAGACCTCATGAA TCAGTCATTAGGTTCTCATAAGAAGCTCA TGGGATTAGTGTCCTTATGAAAGGCTTCA CAGCCTACATCCTTTGCATGTGCAGTTCA GAGAGACCCCTGGCCCCTTCCGGCATGT CAATAGGGTTCAGCTCCTATGAGAATTTA GGGGACATAGTAAGAAGATGTCATCTAT ATGCCACCACTGATCTGACAGGAGGTGA GAGGACATGAGCCCTCACCAGACGCCCA AGCTCAGGCAGTAATGCTCGCTGGCCTG GTCTGCTGATGCCTGGATCTTGGACTTC CCACTCACCTCCTGCTGTGCAGCCTGGT CCATCCTCCAGAACTGTGAGAATACAATT TCCTAACAGGCCACTGACTGGTACTGGT TTTGTTGTTTACAAGTCACCCAGTTGAGA CTGTTGCCTGGGGGTGAGGACCCCTGTA GTACTTTGTAATAGCAGCCTGAACAGACT TGAGACAATGTTTTGACTCTGGGAACCCT AAGACACATGCTGATTCCTA I I I I I I CAT GTGAATTCCAAGCCACCATTGTTTCCCCT AAGAAACCCGGAACACGGAGCTATTAAG GATTCTCTAGGGAAACATAGTTTTACGTT GGTGTAAATGGCAGAATTAGGATTTCAA CTTGTACTTGGTTTTGGGGATGTCCACAC GTCATGGTTGGGTCTGTACAAGGTTAGG ACTGTGTGCATAGAAGGGGGTGTCTGAG GCTCTTTCTTCCTCTTGCCTCAGCTTTTC TGTGTGTTGGGATAGGGATGACTTCAGT CGTCTTCTCAACCCTGGCTTCTCACCCAA GGGAAAGTACATCAGCTGCT GGCTGCAAGACTTTGCTACC

O

ΓS4922190 8 20322594 ATTGATCATTCTAATATTTGTCTCCAGCC G/T ACTGAGCCCAGATCTGAGTCTCCACCTT SEQ_0382

TGTAATTCTCTCCTAGAACCACCTGCCAC CTCTGGATCCACATGAGTCCTTGCCGTC TGTGACCAGACTTACAAGCCATTTCCCCA ACTGTCTCTTGCCACGACTTCTGCAGAG GGGATAACAACCCTGGGACTTCAACACT GCCTCCTCACTGGCCTCCCCACTCTTCA GATCCTGCCATGTGTCTGTCTTTCTTCTT TGCCCTGCTTCAGCTCATTTGCCTAAGTG TGTCTGGGCTCCGGGAATGGCGTTGCCA GTCTTCAAATAATGTAAATCTGATCATTTC TGTAACTCAGGTCCATGGGAGAAACATG ACATTCTTGATAAATGTTCTTCAGCATTTA GGCTCCTCCCCCCGTCTCACACCTCATA CCCATTTGATGGAGGAAGAAGTCCACAC TCTGATATATCACATAGGTGATTCATTCT TCCACAGCAAGGTTATGGATCTGGCCTC GTCTCCTAAACACC AGTTCAATTTTATGCCTCATTTCTAGACC TAAACTTTTCTTCCCTGGCCAACCCTGTT CTCAGCTAGCCAGAGTAGAAGAGAATAG AACAAAGCCACAAGTGTGCCCAGTCTCT GGCCTCCAGCCCTGGGATCATGGTGTTC CCAGTGCCGGAACCCCTTCTCCTTTCCT TCCCGTCATGTCCACATTGTCATCCACTC AGTCCTTTTCAAGGTTCACTCCTACTTAT TAC I I l I I IATGCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 13255790 8 20325402 CTCCTTGTTGTTACCAGCACAACAGCTG A/G TGAATCATCAGACCCCCGAAACGTGTTTT SEQ_0383

CTTTGTCCAGCAAGTCCCTGTTCTATGCA CCCGGCCTTGTCCCTCCATCTGCACTTT AACTGGCTAGGTGCCATTGCCATGAGAT GAGTGATATGGTACAGCTGTTGTTGGAA TCATAAGAATATGCATTCAGAAGATTAAG AACACAGAATTCATCAACAACATGTGTGA AGGTCCTGGGTAGCTACTGCTCTTCTAC AAGAAAAGAAGCCCTGTTACCTGAAAGC CAGGCTTTAGACACCCACCAGAGCTTCT TTTCTACATTTTAGTA I I I I l I AATCAGTG CTGACATTAGGGCAACCAGGAGAACAAA AAGTAGGAGAAACTCTTTCCTTCCACTT GC rs 13266634 8 118253964 TGCTGCACTAGAGTTTCCCCTGCCTTGT en GGGACAGCCAAGTGGTTCGGAGAGAAAT SEQ_0384

CTGTGTGAATGTAGCTGATTATCAGAGCA TGCTAAAGCCCTTAGCAAAAGCTTTACGA AACGTGGCTTCCTCTGAGTGCCCTGCCT TGCACTCACTCACCATTCAGATGGAATCT CTGCCCCACCCCAGCAGGTCAAAGACAA CCAGTTGACCAGGACCCCGACTGCCTTT AGTACTTGAAGTTGGAGTCAGAGCAGTC TCTGTGAAGACCCCTGTGACTAGCTCAG GCCCATGCGTGTGCAATCAGTGCTAATC TCACACCGTCAGTTTCCCAAATTTGACAG TCCCTGTGCTTCTTTATCAACAGCAGCCA GCCACCTTCAAACATGCTGCTATGCAGTT GC rs3802177 8 118254206 AAGGGAGATGAATTTGGTATTGCCGATA C/T ATGAATTTCTTCCTTTGGTTCCTTATTTTC SEQ_0385

GTTACAAACAGCTGTTACTTCGGCTCCAC TATGATGCAGAAACTGCATAGCAGCATG TCAGGAATAATCTATATACACATTCCTGC TTTGAAGGTGGCCTGTCAAATTTGGGAA AATTGAACACAGCTACTGATCAGTATATA ACTGACGGTGTGACTGAGCTAGTCACAG ATCCAATTGATTGATGGATCTCAGTGCCT GGGTCTTCACAGAAAAGGCAGTCGGGGT O CTTCCTTCATGGTGAATGGAACTAAATAA CCTGGTCAACTGGAGATTCCATCTGAAT ATAGATAAAATGTGCATTGCACCATGA GGTGAGTGAGTGCATCGTAAAGCTTTTG CT rs11558471 8 118254914 GTGGTTGTAGAGACCCAGAAGTCTTCAA A/G GAAGGAATAAAGCAGATGCAACCAATTC SEQ_0386

GAACAGCCGACAAAAACATTCGAGTTGA ATTCAGTCCACGAGCATGATGTGAGCAC CCCCACCAAGTTGTTGCCACAGATAATTT TGCTTTGTGCTAGACATTGGGCTTAGCAT AGATATTTACCTGCA TGAAACTATAAAGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11774700 8 118289451 ATCCAGAGCCAAGACTTGTGCCCATAAT C/T GAGTTTTAAGTAACAACCAGTCATTTTCA SEQ_0387

GTGAACTAGAGAATTAGCTTGGAGCTGG TATACACTGATCCATTTGATGCCGCCAAC

GTATGTGTACACATGTGTATATTCTGGGC AATCTGTGAAAAGTGCTGTCCTTATTACC

TTTCTATTGCCTTAAGCAAGTGCAACATG ATGGAAAAAACACTGGTCAAAGAATGAG

GGATACTGACGTGAGCACTGCAAAGAAT CTAAGCTCAAGTATAATTAATACAAGCTC

GAACCATTTTAATTAATGTATTACCCTTCA ACATTCACCAAGGACACACTGTGCACCC

GAGTCTGATCTTGCTTCAATATGGCATA ATCACTTTATATGTATTTTCTTTAATACCT

GAAAATACACTGTGAGGTAGAGATAGTA

GTTCTCAACTAGAGGCTATTTACCCCCAA

GGTGATATTTGGTAATATCAGGAGACATT

TTGGGTTGTCATAACTGGGGGTGAAAAG

GTGAAAAAGGTTATGCTATTGGCATCTAA

TGAATAGAAGCCAGGAATGTTGCTTAATC

TCCTACAATGCACATCACAGCTCCACACA

AATAATTATCTCCAGCCCAAATGGTAATA

GTACCAAGATGGAGAAACCCTGCTCTAC

ATCTCATTGTATAGGTGATGAGATGATGA

AACTACAGCTC

W

O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2050831 9 77117950 TGAATAAGCGGTGAATAAACA I I I I I GTG A/G TCTAGGTTCTTGACTGAGGCTCTATGAAT SEQ_0388

CTAATCAACATTGAATTACTTTTCTTTCAG GGAAGACAGATTAACATGAGAAAACAAG ATTCAAACATCTACTTCTTTGGGAACATC CAGATTTACTAGCATTCATATTTCATGGG ACAGATTTCACAGAAAATAATTCCTCTCT TACATGCAAGAAGCTCAGGAATGAGTAA TGGAACTTCCATCTGTTTCTGAAGATGGT CTCAAGGTGGTGATTAAAATTTGGGTTTA AAAATGAAACTGCTTAAGGATA I I I I I CTT TATACCAGTTTGGGCTTAAACAAAGGAAA ATTTTATTAAAATAATTTCTGTTTTGAGGC AGAGGTTTTGGGCTTCAGGGATAGGGGT ATATTTTTCTCAAAGGACCACACAGAGGA TGCTGGGGAGGCAAGGTATATGGGAAG AGGAAAATATCTTTTCCTTTTAAA GCGACCAGAAAAAGTATGGTACACAAGG GTAAAGTTTGTTACGCAGATATGTCAGTG TTTTCTCCGTTGATAAGAATGTCTTGGGA GTAAGAGTCATCTTCCCTGGTACAGAAA GGAAGATACCTTTACAAGGTAGATTTCTC TTATAAATGTTAATTTCCCTTAGAAAAGG GAAACTTAGGATCTGTCTTCAGAGCTTTT CCTGTGTCTGCTGTTTCTTAAAATAATTG ACTCAGTGTAATCCTTATGCCAAAAAGAC ATGTTTTCGAGTGGCGTATTTTGGTCTTC TGTAGTCATATAAGAAATTTAAGGCAATA GCAGATATTTGTATATTTTCAGGAAATTTT AACTAAAATTTATTTTAAATAGCACAATTC O CTTAAAGTTGCTTTTGCAATGGGA I I I I I TTGGTATAAAGTTGAACAGAAAATGACAA GGACCAGCCAGGCGCAGTGGCTCATGC CTGTAATCCCAGCACTTTGGGAGGCCAA GGCGGGCGGATCATGAGGTCAAGAGAT CGAGACCATTCTGGCCAACATGGTGAAA CCCCACCTCTACTAAAAGTACAAAAATTA GCTGGGAGTGGTGCTGCACACCTGTAGT CCCGGCGACTCGGGAAGCTGAGGCAGG AGAATCGCCTGAACCCAGGAGGCGGAG GTTGCAGTGAGCAGAGATCGTGCCACTG rs945384 136892579 GCCCCCAGCCCTGGAGAGGCTCCTTCC C/T GAGGGTCATCTCCCGGAATTCCTTGATG SEQ_0389 CTGGCAGGGCTCATGCCCAGGGGCTGG GAGGTGCCCCGGGTGGGCTTGTCAAAC GGGATGGGAGGTCTGCCCAGGGTCCAC AGTACCAGCTCCCGCCGGGGGGCCGCA TTGGGCCCATCTGTGCCTTTGCGCTGGG TCCGACCGGGCCTTGGAGTCGAGGGTC CATGTTGGTGCCAGGGCCGCCTGCTGG TCCTCAATGCCACACTTGATGGTTACATC GCATATGACCGTGGTGTGGACTCCTGCC CTTGTCCCGCCAGAGCCCGCTGTACACC CTGCCCCCTAGGAGAGCTGCCTGACCTT TGGACAGGGCCACAGAGGTCCTCCGTG GAGGAAGC CAGACAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10998852 10 70975273 TTTGGGGACTTCCTGCTCCCCTCTGATCT C/T GGAGGCAGTCAAAGAAGCTTAAAGAAGG SEQ_0390

CCCCAGGCCATCTCTGTTCTCAGAATACT TGAAGCTTAAATAATAATCATAGCCAACA

GGAGGAGAGGAGGCTACGGAAATGCGG AAAGCAGGCACCAGGATTTCCTAAACAC

GTTTCATCCAGAGACTCAGGGGCACCCC CTAAGGGATTAACTGCTTTACCCTCCACT

TAAGTCCTCAGCGGGCTCACCGGTCAAG ACTCTAGGAGGTAGCTGAGGCTGGCTAA

TCAGATGCCTGGGGAGGGAGGCTGAGG CTTGCTTAAAAATCCCAGCTAGGCTGGG

GGAAGGGCTAAGGTGAGGATGATCTGCA TGCGGTGGCTCACGCCTGTGATCCCAGC

CAGT ACTTTGGGAGGCGGAGGCAGGCGAATC

ACAAAGTCAGGAGTTCGAGACTAGCCTG

GCCAACATGGTGAAACCTCGTCTCTACT

AAGAATACAAAAAATTAGCTGGGCGTAGT

GGTGGGCACCTGTAATCCCAGCTACTCG

GGAGGCTGAGGCAGGAGAATTTCTTGAA

CCCGGGAGGCCAAGGTTGCTGTGAGCT

GAGATCGTGCCACTGCACTCCAGCCCGG

GTGACAGAGTGAGACTCTGTCTCAAAAA

TAAAACAAAACAAAACAAAGCAAAAAACA

AACAAACAAACAAAAAAACCAA rs10998854 10 70976345 TTTAACATTATCTCTTCCCTGATGACTCC C/T GATTCAACTCTGCCCTGACACCCTCATCT SEQ_0391 w

CAAACTTTTGTCTCTATCCTTGACAAATC CCCTTTTCAACCAAACACCTCTCCTGCCC E

CCATGGCCTATGGGACACATTCATCTGG CATTG I I I I I GCCAACCCAACATCCAATC

ATAACTCAACTCAAAAACACAAGAGGCCA ACCAAGGTAATTCTGCCTTTGAAATCTCT

TCAACTGAACTCATGCTTCCTCCAAACCT CCTGCACCTCCCCTCTCCTCATCTACTAA

TCTCACACTGGAATTTCTGTCCTACGCAT GTCTCCATCATCTCATACTTTGACTATTT

CCAAGGTGGAAACTCTTGGGTTCTCAT GACATAGATCCCTAACAAATGTCACT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs297050 10 70976430 AGGCACCAGGATTTCCTAAACACCTAAG A/G TCACCAAGGTAATTCTGCCTTTGAAATCT SEQ_0392

GGATTAACTGCTTTACCCTCCACTACTCT CTCCTGCACCTCCCCTCTCCTCATCTACT

AGGAGGTAGCTGAGGCTGGCTAACTTGC AAGTCTCCATCATCTCATACTTTGACTAT

TTAAAAATCCCAGCTAGGCTGGGTGCGG TTGACATAGATCCCTAACAAATGTCACTG

TGGCTCACGCCTGTGATCCCAGCACTTT CTCAGTCTTTCTGCTGCAGACAAAGAGC

GGGAGGCGGAGGCAGGCGAATCACAAA CCTTCAAACCCAGTCTCACAAAAATCTCC

GTCAGGAGTTCGAGACTAGCCTGGCCAA CTGCTCAAAGAGTTCTGTGAGGCCGGGC

CATGGTGAAACCTCGTCTCTACTAAGAAT ACAGTGGCTCACATCTGTAATCCCAGCA

ACAAAAAATTAGCTGGGCGTAGTGGTGG CTTTGGGAGGCTGAGGCAGGAGGATCA

GCACCTGTAATCCCAGCTACTCGGGAGG CATGAGGTCAGGAGTTCAAAACCAGCCT

CTGAGGCAGGAGAATTTCTTGAACCCGG GGCCAACATGGTGAAACCTCATTAAAATA

GAGGCCAAGGTTGCTGTGAGCTGAGATC CAAAAATAAAAAATTTAAATACATAATTTA

GTGCCACTGCACTCCAGCCCGGGTGACA AATTAAAAATTAATTAAAATACAAAATTAA

GAGTGAGACTCTGTCTCAAAAATAAAACA AAATATAAAAATTAACCGGGCGTGGAATC

AAACAAAACAAAGCAAAAAACAAACAAAC ACATGCCTGTAATCCCAGCTACTCAGGA

AAACAAAAAAACCAAACAAACAAAAATCC GGCTGAGGCAGGAGAATCTCTTGAACCT

CAGCTAGTGGGTGGCCGAGTTTACCTTG AGAAGATGGAAGTTGCAGTAAGCTGAGA

TATTTCCTTGCTATCTACCCATTCCTAGT TGGCGCCACTGCACTCCAGCCTGGGCAA

CCGTATTCTTCACCTCCTTGTGGCATTTG CAGAGTGAGACTCCATCTCAAAAAAAAAA

ATTTTGTTAAGACTCAATCTΠTGGCTTC AGGTCTGTGCCATCCCTTAACAAAACTCC _W

CAGAACTCCACTCTCTTCCTGGACTCTTC TATCACTTGCTCTTCATCTTCCATGTGCT K

TAACCTCTCTGATCATTCCATGTGCGTCT ATGCACCCTATACCCCACTATAGGCACTT

TCCTAGGGGCCCACCCAGGGCTTCTGCT ATCTAAACACTCCT

GCCAGGGCAGTGTGTGTATGCACAAACA

GAGAGCCTGCGTAGTCTCTAGATTCCAG

ATACTCTCTGGAGTAGTGCAGTTTGGCA

GTGTTGACCCTACCCCTTGAATGTGCCT

GGGGTTTATTCCTTGGCCTTCTCATCTGT

AACCAGACTCATTGTTTTAACATTATCTCT

TCCCTGATGACTCCCAAACTTTTGTCTCT

ATCCTTGACAAATCCCATGGCCTATGGG

ACACATTCATCTGGATAACTCAACTCAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10823405 10 70979963 TAGGCAGAACATTTCCTTACTCCTGATGT A/G TGACAGCAGACTACTCATCAGAAACTATG SEQ_0393

TTCTTTCTAGACTTCTGCTTCCAGTTGTA CAAGCTGGAAGACAATGAAACATCTTTAA

AGGGAAGCCCTATAATTGAGACAGACTT ATGCTGAAAGAAGAAAACCCCAAAAACC

ACCATTCTCCTGTAAACAGAAAACTTGAC TATTAACCTAGAATTATGTTCACAGTGAA

AAAACATATGAAATAACAGTTTTCAGACA AGTACCTTTCAAAAATTAAGATGAAATAA

ATGGACTGTGATCCTTGAGAGAATGGAA AA I I I I I I I AAAAATGCAAGCTAAAGTAGT

ACAAATGAGGTGAGCCCTGTGATCACCT AGAATTTGTTGCCAGCAGACTTGCTCTAT

GGCTTTCTGCTGGAGATTTCTGGTCTGT AAGAAACATTAAAGGAAATTCTTTAGGAG

GATGCAGGGATGGGGAACCCAAAGAGA AAGGAAAATGGTATCAGGTAGAAACTTG

GCCTGGTGGTCTTGCTGAGTTGAGGATA GATCTACAGAAAGGAGTGAAGAAAGCAG

CAAAGAAGAGAATTCAGGAGGTTGAGGC GAAATGACAGAGATGTGGGTAAATATAAA

AGCTAGGGTTTGCACGTAGTGGAAAGAT ATATGTTGATTGTGTAAAGCAAAAGTAAT

TTTTACAGAGAAAGTTTCAGAAACATGCA AATGATATATTTGGCAGTTTATAATACAT

TAGAGCTCCCTTGAGTTCCCATGAAGCT GTAGAAAGTGTATGATGACAACAGCACA

AACTAAAAAAAAAATCCAGGGAAAGGAC AAGGATAAGAGGGAAAAATGGAAGTATG

AATTACTTGGGAGAAGTAAGATAAAAAGA TTGTAAGGTTCTTAAGGTATACATGAAGT

TTCTTAGAGTTCACACAGGTTGGGGAAT ATATAATATATTATTATAATCTTATTTGAT

CATTTGAGGTTCTACTAACCAGGATGGA GATAGACTGTGATAAGTTAAGCAAGTATA

GACGCATTGCTATAATATGTGAGGCATTT TTGTAAGCCCTAGAGCAACACTAAGAGA

ATATATTTGATGAAAGATTCTAGAAGGGT GTAATGAAGAGGCATAGCGACTAAGCCA W

CATATTTCAATGGTGGGGCTAACCTAGCT ATAATAGAGATAAAATGAAATCTTGATGT C

CTAGAGTGAAGGTTACTGTAGTCCCATTT TTCCTTCTGTGTGTAGGGACCCCATTGG

TTTAAGAGCTTAAAAACAAGCTTTAAAAA TATAACACACCTGGCTTCTCCCTGCTCTC

GATTATAGTTGTCTTTTAATGGCCTCCAG TCTTTCATTCTGCTCCAGCGAATATTGAG

GACAAAATGCAACCCCTCTTTAATGGAAT TGACTTAT

ACAATAAAATCAAGCACTCAATGATGTAA

ATTTGCATTACCCAGCATCTAATCAAGAA

TGACTAGAAATACACAGAATTAGAAATAT

GTTACCCATAATTAGATGTGGATGCTAAA

GCAACTCCATCTTGGATGCTAATCTGCCA

TGTTGACTTCTGATTAACCCTGTTCTGGG

AAGGCCTGTAAGATTTCTACTTTATCTAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10998855 10 70980137 TTCTAGACTTCTGCTTCCAGTTGTAAGGG C/T AGAATTTGTTGCCAGCAGACTTGCTCTAT SEQ_0394

AAGCCCTATAATTGAGACAGACTTACCAT AAGAAACATTAAAGGAAATTCTTTAGGAG

TCTCCTGTAAACAGAAAACTTGACAAAAC AAGGAAAATGGTATCAGGTAGAAACTTG

ATATGAAATAACAGTTTTCAGACAATGGA GATCTACAGAAAGGAGTGAAGAAAGCAG

CTGTGATCCTTGAGAGAATGGAAACAAAT GAAATGACAGAGATGTGGGTAAATATAAA

GAGGTGAGCCCTGTGATCACCTGGCTTT ATATGTTGATTGTGTAAAGCAAAAGTAAT

CTGCTGGAGATTTCTGGTCTGTGATGCA AATGATATATTTGGCAGTTTATAATACAT

GGGATGGGGAACCCAAAGAGAGCCTGG GTAGAAAGTGTATGATGACAACAGCACA

TGGTCTTGCTGAGTTGAGGATACAAAGA AAGGATAAGAGGGAAAAATGGAAGTATG

AGAGAATTCAGGAGGTTGAGGCAGCTAG TTGTAAGGTTCTTAAGGTATACATGAAGT

GGTTTGCACGTAGTGGAAAGA I I I I IACA ATATAATATATTATTATAATCTTATTTGAT

GAGAAAGTTTCAGAAACATGCATAGAGC GATAGACTGTGATAAGTTAAGCAAGTATA

TCCCTTGAGTTCCCATGAAGCTAACTAAA TTGTAAGCCCTAGAGCAACACTAAGAGA

AAAAAAATCCAGGGAAAGGACAATTACTT GTAATGAAGAGGCATAGCGACTAAGCCA

GGGAGAAGTAAGATAAAAAGATTCTTAGA ATAATAGAGATAAAATGAAATCTTGATGT

GTTCACACAGGTTGGGGAATCATTTGAG TTCCTTCTGTGTGTAGGGACCCCATTGG

GTTCTACTAACCAGGATGGAGACGCATT TATAACACACCTGGCTTCTCCCTGCTCTC

GCTATAATATGTGAGGCATTTATATATTT TCTTTCATTCTGCTCCAGCGAATATTGAG

GATGAAAGATTCTAGAAGGGTCATATTTC TGACTTAT

AATGGTGGGGCTAACCTAGCTCTAGAGT _W

GAAGGTTACTGTAGTCCCA I M i l I AAGA £

GCTTAAAAACAAGCTTTAAAAAGATTATA

GTTGTCTTTTAATGGCCTCCAGGACAAAA

TGCAACCCCTCTTTAATGGAATACAATAA

AATCAAGCACTCAATGATGTAAATTTGCA

TTACCCAGCATCTAATCAAGAATGACTAG

AAATACACAGAATTAGAAATATGTTACCC

ATAATTAGATGTGGATGCTAAAGCAACTC

CATCTTGGATGCTAATCTGCCATGTTGAC

TTCTGATTAACCCTGTTCTGGGAAGGCCT

GTAAGATTTCTACTTTATCTACTGTTATCA

TACATGTTGCCCAGAGGTCAAAACAACC ΓS10823406 10 70982029 GCGATATGAGCCCAGGTCTCTGGGAATC A/G TGTGGGAAACACAAGCAGAATCAGAAGT SEQ_0395

TAGGCCAGTGTGATTTCTGCTATATTCTG TCCCCTGGCCTCTCCCTGGGTCCTCTTT

TGGCCAGTCAAGCTCTCTCCAGATGGGC TTCCCACCCCCAACTAGTGGCTGAGCCA

AAAGAGAAAAGAGGGACAATATTTCAGA AGAGGCTGGAGCTAAAGCCTCTCCCCCA

ACTGCCTGAGTTTATTCTAAGGGAAGCT TTGGCAACTTTACTGATCCCTCCCCTAAA

GGACCTAGGATGGGGGATGAGACAAAG CTTTCACTCCAGTGGTTAAATCATTGTCA

AACTTCATGGGTGCAGCAGGTCTCTTGG GAGACACAAGGTCAGGCTACCAGCTGGC

TGTC TG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs297046 10 70982827 TTCTTTCCTCCCCTTGGCTCCCAGGGAT A/C GATGCAGCCCACTCAGTCCCCACAGCTA CTGGTCCTGGGAGTCCTGGGAGTCCTG TTGCGTGAGCATGATATAACTACGGTCC GGTCTCAGTGTCCTGTAGGCGGGGAAGA CCACTTGCAGATGGGAAAACTGAGGGGC TCTTCCAGAAATCGAACATGAAAATATAA AGAATGGCTCAGTGAGTTGCTCATGGTC AGCTATACTTTAGCTTTTAGGATGGCAAT ACAAAGCCAATAAGTATCGGAGGTTGCT GAGAAAGTAGCGTCTACTTTTTAATGATG TCTGTTGTCGGTTTATATCTGGCCATGGG AAATCCCTTAGACTAATCATAATTTACAAA GCAAGGCTTTGCCCTTTTGAAGACTCAA CTCACATGGTAGGGGGTTGTCCCCCCAA CCCATCCCCACTATGGGAAGTGGAGCAC I I I I I CCTGGCCCTTTCTCACCTGGAATA CTCATGATGAATAGTCATATCCTTCTCCT TTTTCAAAGCTAGTAGAAATTTTGCCGCC TCTGGGAAATCTTCCCTGTTTTAATCTCC GGCAAAGATTTTTCCTTCTTCACCCTGAC TTCTATGCTGCTCCCAGGGTACCCACCT CCCAGGAGCATGGGGCTTCTTATCTGCC AACTCAGC rs192710 10 70983142 ATATAAAGCTATACTTTAGCTTTTAGGAT C/T CAAAGCTAGTAGAAATTTTGCCGCCTCTG SEQ_0397 GGCAATGAGAAAGTAGCGTCTAC I I I I IA GGAAATCTTCCCTGTTTTAATCTCCGGCA ATGATGAAATCCCTTAGACTAATCATAAT AAGA I I I I I CCTTCTTCACCCTGACTTCT TTACAAAAGATGCAGCCCACTCAGTCCC ATGCTGCTCCCAGGGTACCCACCTCCCA CACAGCTATTGCGTGAGCATGATATAACT GGAGCATGGGGCTTCTTATCTGCCAACT ACGGTCCCCACTTGCAGATGGGAAAACT CAGCAACTCCTCTCTCTGGTTGGAAGGC GAGGGGCAGAATGGCTCAGTGAGTTGCT TGGATGACAAACCCCTGGAGGGTGGGA CATGGTCACAAAGCCAATAAGTATCGGA GCCATGCTACATTGGCCTCCATTCCAAC GGTTGCTTCTGTTGTCGGTTTATATCTGG CTCCAGCCACGGAGTGCCCTC CCATGGGGCAAGGCTTTGCCCTTTTGAA GACTCAACTCACATGGTAGGGGGTTGTC CCCCCAACCCATCCCCACTATGGGAAGT GGAGCAC I I I I I CCTGGCCCTTTCTCACC TGGAATACTCATGATGAATAGTCATATCC TTCTCCTTTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs11597949 10 70983189 TGATGAAATCCCTTAGACTAATCATAATT C/T AATCTCCGGCAAAGA I I I ! I CCTTCTTCA SEQ_0398

TACAAAAGATGCAGCCCACTCAGTCCCC CCCTGACTTCTATGCTGCTCCCAGGGTA ACAGCTATTGCGTGAGCATGATATAACTA CCCACCTCCCAGGAGCATGGGGCTTCTT CGGTCCCCACTTGCAGATGGGAAAACTG ATCTGCCAACTCAGCAACTCCTCTCTCTG AGGGGCAGAATGGCTCAGTGAGTTGCTC GTTGGAAGGCTGGATGACAAACCCCTGG ATGGTCACAAAGCCAATAAGTATCGGAG AGGGTGGGAGCCATGCTACATTGGCCTC GTTGCTTCTGTTGTCGGTTTATATCTGGC CATTCCAACCTCCAGCCACGGAGTGCCC CATGGGGCAAGGCTTTGCCCTTTTGAAG TC ACTCAACTCACATGGTAGGGGGTTGTCC CCCCAACCCATCCCCACTATGGGAAGTG GAGCACTTTTTCCTGGCCCTTTCTCACCT GGAATACTCATGATGAATAGTCATATCCT TCTCC M i l l CAAAGCTAGTAGAAATTTT GCCGCCTCTGGGAAATCTTCCCTGTTT

RS 10998857 10 70988081 I I I 1 1 I CTCATTATGAAAGATAATGTTATG A/G CTACAATCTACTAAGGAGGGAGGCAGCT SEQ_0399

AATACCTTTGTTGAGACATTTTAATGCAA CTCAGGCCTCCTGGAAAGGTCTGGGCAG TTTCTGATAATTTCCTCAGGAGGATTGTC AGGAGAGACAGGCGCTGCAGGCAGGAA TGGGCCAACAAATTTGGCTATTTTAAGGC GATTAGGTGATGACATGTGGGTGGCCCT ATTAGATAATACTGAAAACAAAGGCTGGA AGAGGGAGAGGTGGTGGGGAGGCTCCA TCAATTTCTTAAAAACTGAAAGTAATATAT GGCAGGACTCCCTGTGTGGCTGGGGAA GGGCATGATAAAAATTTTAAAAGTAGAGA CAGTGCCCTTCAAGAGGCAGGACAGGG AAATCACTAATCATGACCATGACAACAAC CGGGATCCACAGGCATTGCA ATCATCAATAACAACAGCTAACAGTCGCT GATGGCTTCATGCAGTCTCCTCCTTTTAT ATΠTATATAGTATACACTTACCATATATT ATATTACAGATTCTATACTTAATCTTTATA GCTATCCTTTGAGAGAGGTACTATAATTA TTCCTATTTCACAAATGACATTGGGGTTT AAAGAGGTCTCCTACAATCACCAAGCTG GTAGGTGATAGATTTGTCACCTGAACTCA AGGAGCCTGACTCTGAAGCCGGTGCTGT

TGAGC rs12781626 10 70991180 AGGCAGGCTTCTTCCCTTCCCACGCCTT A/G GCAGGTTGCAGGATGAGCACACGGAAG SEQ 0400

CAGCCTGCAGAGAGCCCTCTGCCTGCCC CTCAGGGATGTGCTGGTTCACACGTAGT CTCTTTTCTGTTCTCAGTCTTATGTATTTG GACAGCACACACACAGAAACAAGTGCAA GCAGAGTTTTCTCCCTACCTCCTCCAGG CACATGGCACACACACATACAACCCTGA AAGTCTCAGTGCTGTGCTTATACCTTCAT GGCAGGTATGTCAATTCCTGCTAACAAAT GCCTTTGCTTGACCAGTTTTCCTCTGGTC GGGATCAGAGGTTAGAAAGCCTGAGATG TCTGTCAGTCAACCAGAAACTGCAAGAG CAAGAGCAGAAGAAGGGGGGACCTGGC

CTTGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2798253 10 94192885 TC I I I I I I I I I AGACAGAGTCTCGCTCTG C/G TAATTTTATATTTCTAACTCACCCTACCTT SEQ_0401

TCTCCCAGGCTGGAGTGCAGTGGCACAA ATAGTTGTGGAAAGATTCCTCTGAAACAC

TCTCAGCTCACTGCAACCTCTGCCTCCT TTCCCAAAATATCTTTTGCTACAATAAAG

GGGTTCAAGCGATTCTCCTGCCTCAGCC AACAAGTGTGGCTGGGCACTGTGACTCA

ACCTGAGTAGTTGGGATCACAGGCGCcc TGCATGTAATCCCAGCACTTTGGGAGGC ^■

GCCACCACGCCTGGCTAA I I I I I GTATTT CAGGGAGGGACGATTGCTTGAGCCCAG

TTAGTAGAGACAGTGTTTCACCATGTTGG GAGAGTTTGAGACCAGCCTGGGCAAAAT

TCAGGCTGGTCTCAAACTCCTGACCTCA GGCGATATTCCTGTCTCCACAAAAAATTA

GGTGATCCGCTCACTTGGCCTCCCAAAG AAAAATTAGCCAGGTGTGGTGGCGTGCA

GGCTGGGATTACAGGTGTTAGCCACCGT CCTGTAGTCCCAGCTACTCGGAGGCTGA

GCCCGGCCTGACTGGGCTCCTTCTGATT GGCAGGGGGATTGCCTGAGCCTGGGAG

GGTTGCTGCAATCACATG I I I I^' I AGGAAA TCCGAGGCTGTCAATGAGCTACGATGGT

AATGGTCTACTTGGGGTTTTCCTGCTTCC GCTACTGCACTCCAGCCTGGAATGAGAC

TTAAAGTTTCAGTTGGAGGCTGGGCGTG CCCAGCTCTAAAAAATACAAAAAAAAACA

GTGGCTTACCCCTGTAATCCTAGCACTTT GA

TGAGAGGCTGAGGTGGGCAGATTGCCT

GAGCTCAGGAGTTTGAGACCAGCCTGGG

CAACAAGGCAAAACCCCATCTCTACTAAA

AATACAAAAAATTAGCTGGGTGTGGTGG

TGCACACCTGTAGTCCCAGCTATTTGGG W

AGGCTGAGGCAGGAGAATTGCTTGAATC ^

CGGGAGACAGAGGCTGCAGCAAGTTGA

GATTGCACCACTGCACTCCAGCCCGGGT

GACAGAGAGAGATTCTGTCTCAAAAAAAA

AAAAAAAAAGAAAAAAGTTTAGGTTGGGT

GTGGTGGCTCACGCCTGTAATCCCAACA

CTTTGGGAGGCCGAGGCAAGCGGATCA

CCTGAGGTCGGGAGTTTGAGACCAGCCT

GACTAACGTGGAGAAACCCCGTCTCTAC

TAAAAATATAAAATTAGCCAGGTGTGGTG

ATTCATGCCTGTAATCCCAGCTACTTGGG

AGGCTGAGGCAGGAGAATCGCTTGAACC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6583813 10 94199919 ACTTCCCTCTGAGTGACGGAAAATTCCTT err GCCGCCGACAACGACAACAACAACAACA SEQ_0402

ATCACATACTGACCTTGTTATTAGAAGAC ACAACAACAACAACAAAAGACATACTTTT ACTTGATGCAGTATTTAGGGGTAAGGAG TTCAAGGGTATCCATGTGGAAAATGCTCA TCATAACATCTGCAACTTACTCTCAAATG GTATAAATAGGCTACTGAGGGGAAGAGT ATTTGGCAAAACACACACGTGCGCACGC TCCCACACTGAGTACGTGACCCCTTCCT ACACATACACACATAAGAGAGAGAACGG ATATGCACAGGAAGAAGACTGCAGAGAA ACAGGATATGAAACAAACAACATTGGTCA ACACCATGCAAGCAGTGGCTGTCTCTGT ATACAGGGGGAAGGGTATATGGGAATTC GGTGGTGTCACAAGTGAAAATGACTCTT ACTGGACTATTTCAACAACTTTTCTGTAG CCTCACACTCCTCTTCCAAAC I M I I I I I I ATTAAACACTTTTCAATATATAAAGTTAAA M I I I I I I I IAAGACAGAGTCTCACTCTGT TAATATATTCATATTCCATAACCTGGCAAT CACCCAGGCTGGAGTGCAGTGCCACGAT TTAAGGGAATAATCAGAAAATCACACACA CTCAGCTCACTGCAACCTCCGCTCTCTG TACTCTGCACAAGAAAGTTTATCACAGAT CAACCTCCGCCTCCCAGGTTCAAGCGAT CAGAACTTGAAAACACCGTAAAACCCCC TCTCTTGCCTCAGCCTCCTGAGTAGCCT ACAGAGGATTCAATAAACAAACAATACGA GCCACCACACCCGGCTAACTTTGTATΠT TACCAAAGAGC TAGTAGAGATGGGGTTTCACCATGTTGG CCAGGCTGGTCTTGAACTCCTGACCAGG

TGGGTGAGTGATCCACC rs11187007 10 9₄204560 GCATACCTCAGTTCTACTTAATATACTGT A/G GGACTTAGAGGCTTCGCATCAAGGCTTC SEQ_0403

I I I I I I GTTTTGGCTTGAGGCCGCTCTAC AGCAGAGTAGCAGAGGCTGGTGTGCCC so CTAATAACCCATGTATCTTGATCTGCTGA ACCCACAAAAAGCCTAGTTACACTGCCA CCTTTCTTCTGGATCAGTATGTCTGGAGG GTTTCCTCCTCTTGCAAGCTAATGTCAAT GTCGTGAATTGGTCTGTACAAACCTATG CCTTCTAGATGATTAAAATACGCAGGTAA GTAAGTGTCCTTAGTCCTTTTGGTTTTCC CATGGGAGAGACTAAGAAGTCTCTCTCC TCTGGGCAAACAAGGGCTGGCTCACCA AGTATTCAGTGCTGGGAACAGATGTGGC CAG rs2149632 10 94222227 GCATTTTGGATTATTGTAGGAGTATATAT err AATCTAGTCTCCTATCCAATGCCTGAGGC SEQJMCM

ATCAAAATGGAATAATTATTTACTTGAGC AATCAACAAAATAATGACTTTCAGTACTTT AGAAAATTTAAATAAAAAAAGAACTGACT GCTCGATTTGTGTCACTGATGACATCAAA ATTCTCTTTACAAAATCCATTTTAGGAAG AGCATAGTGTTACGTAAGTATAAGAACTT CCTTCATATCCCTCTGAGATACTATAGAG GTCACAAAAGGTTATTAAAACATTCAACA CTTATTCTGCTTAAAATTAACATGCCATCT GAATTC i M M 1 1 1 1 1 1 i i 1 1 1 1 1 1 GAGATG GACCTAGATTCTAACGAAGGGTGAATAA GAATCTCTGTTGCCAGGCTGGA AACCCTCAAACCTTTGCTTTTTGATCATt ATAAAAGTAGGCTTCGTTTTGGAAAACAT TTAAAATTAATTGTGTGGTA I I I I IAAAAG GTATAATTCTTGCTATTAATTGCATATGAC CATAATCATTTTGCAAAGAAAAGCATATT AACTGTCCTGATAAAAAAATGTACCTGTT CTAGTAAGTGA I I l I IA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11187033 10 94252339 ACCATGTATGTGTGGAACTATATCTGGAC /VT TTAAACCATTTAAATTATGTGAACTATATC SEQ_0405

TCTGTTCTCTTCCAATGATTTCTTTGTCTA TCGCCATCCCCCACTAAACTACGTCAGG

TCCATATGATGTCAATACTACCGTGTCTT CATGAATAACTTAACATATTACGTTATACA

AATTACTGAAGCTTTATACTAATGTCCTC AATATTTAATCTACAACTTTCTCTGTTGTT

AAATCTAGTGGTTTAATTCCTCCCACATT CACTGAATGGAAAAGGAAAGATTTCTTCG

TGGTGA I I I I I I I l I I I I I CCGGAGTGTTC I I I I I CAATTCCTCAGTAAATTATCTAGAG

TGACTTATCTAGGTCCTTTGTATGTCCAT TTGAAAAAGAGCATTTGCTGTTA

ATAAATTTTGGAACCAATTTCTGAAAAAA

GGAAAAACAGCCTGGCCAACATGGTGAA

ACCCCATCTCTACTGAAAACACAAAAATT

AGCTGGGCGTGGTGGCATACACCTGTAA

TCCCAGCTACTTGGGAGGCTGAGGCAAG

AGAACCGCTTGAACCTGGGAGGCAGAG

GTTGCAGTGAGCTGAGATCGCACCACTG

CACTCCAGCCTGGGCGACAGAGTGAGAT

CCTGTCTCAGAAAAAAAAAAAAGAAAAAG

AAAAAAAGAAAAAAAAGGCCAGGTGCAG

TGGCACATGCCTGTAATCCCAGCACTTT

GGGAGGCTGAGGTGGGAGGATCATTTG

AGCTCAGGAGTTCGAGACTAATCTGGGC W

AACATAGTGAGACTCTCTCTCTACAAAAA «

AATTAAAAAATTAGCTGGGCATTGGTGGC

ACATGCCTGTAATCCCACCTACTTGGGA

GGCTGAGGCATGAGAATTGCTTAAACCC

AGGAGGAGGAGGTTGCAGTGAGCCAAG

ATGACACTAGTGCACTCCAGCCCGGGCA

ACAGAGCAAGACTCTGTCATTAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAGCCGGTGC

ATTGGCTCACGCCTGTAATCCCAGCACT

TTGGGAAGCCAAGGTAGGCAGATCACAA

AGTCAAGAGATCGAGACCATCCTGGCCA

ACATGGTGAAACCCTGTCTCTACTAAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10509645 10 94267846 CTTAATTAGTTCTCTCATTTTCTCACTAAT A/C TCTCGTATCAAGGTGAAATTTGAGTATTG SEQ_0406

GACCAGTTCAAGCTGGGCACAGTGGATC ATGAAGCCTTTCTTTTCTACTAAATGAAG

ATGCCTGTAATCCCAGCACTTTGGGAGG ATTCTAAAAGCCACAGTTCTAGAGGGAG

CCAAGGCAGGTGCATCACTTGAGGCCAG TTTTGCTTAAGCTCCTTAGTGCTTTACAC

GAGTTCAAGACCAGCCTGGCAAGCATGG TGCCATCTCGGCTCACTGCAACCTCCAC

TGGCATGCCTATCATCCCAGCTACTCAG CTCCAAGATTCAATTGATTCTCCTGGGGC

GAGGCTGAGGCATGAGAATCACTTGAAA CAGATATCTTCTGACTGCATGGCCTTGAA

CCAGGAGGCAGAGACTGCAGTGAGCCA CAAGTTACTTTACTTCTCTGTGGCTCAAT

AGATCACACCACTGCACTCCAGCCTGGG CTCCTCAACTGACATTAGTGGACTTACAG

TGACAGAGTGAGACTCTGTCTGATTGATT TACATAATGAGAAAAATACACGTAAAAAA

GATAGATAAATAAAATAATATAAATAAATA AGTATAAGACTATTACTTAACAAAAATGTT

AATAAGACCTAGTTCTGCTTTACTGCCCA AAAGTCTTACGACACCAACTGTTGTTTAG

GAGAGGTCCTGAGACATTCTCTATTCTCT TATGCAGAGAATGAGAACTCAGACACTG

CACTCTACCTGAGGGGTCCAGATGCTCT CCTGATGGAGTGCATCTTGAATCAACCG

TAGGTGCATACCCATAGTCCTAACTCCTT ^' CTACAGGAAACAACCTAGTCAATCTGAA

AGGGAAAAAAAAAGGCCTTTTGCTGGAG GATGTCCATATCCTACTACATAGTAATTC

AATGTTTGAAGTT CACTCCTGGATATATGTATCCAGAGAAGT

CTGTGTACAAG rs2421943 10 94301795 CTCCATCTCAAAAAAAAAAAAAAAAAAAG A/G TGAGAAACAATCAATATTCTAACAAACTA SEQ_0407

AAAAGAAATCAGCTAATCACAAAAGGACA ACCTAACAACTATAAATGAGTAACATAAT W

AATACTACACAACTCCACTTATATAAGGT CACATTGAAGGAGTGTAAAAGAAAAGAA O

ACCTAGAGTAGTCAAATTCACAGACAGAA CTTAACTATGGAAAGCTGGATTTTGACTG

AACAGACAGGTGGTTGCAAGGGTCTGAA GATACAATAAAGCCTAAGAGAAAAAGAAC

GGGAGGGGAAATGGTGAGTTATTATTTG TACATGCAAATATTGTGACCTATTTTAAAA

ATGGGTACAGAGTTTCAGTTTGGTGAGA ATGTTTCTCACAGGTGAGCTAGCAATTAT

TGAAAAAAGTTCTAGAGATGGATGATGGT GAAACTATGTGTACACTAGAATTGAGGAA

GATGGTTACACAACAACGTGGATGTATTT ATAAGAAAGTAAATTGTAGAAAATGAAAT

ACTGCCACCGAACAATACACTTAAAAATG CCAGTGTTCTCATTGTTGGAAAAAGATGT

CTCAAAATGGGCCAGGTGCAGTGGCTCA TATAAATAAGAAATGGGAGAAGGCTACAA

TGCTTGTTACCCCAGTACTTTGGAAAGCC TTGTGGTACTAAGTTGGAATCAAAGGTAT

AAGGTAGGAAGATCACTTGAGGCCAGGA CAATACAAACTTATA I I I I IATTATATACA

GTTTGAGACCAGTCTGGGCAACATAGTC AAAAGACATAGAAATATAAAAACGTGTAT

AGACCCCATCTATACACACACACAAAAAG ATGTGGCTGTCCACCAGAGGCACTAGAC

GTCAAAATGATAAATTTTATGTTACATATT TGGCCGGCCACTAGAAGCAATGACACCT

CTTTATCACAATAATAAAACCAACCATGA CAGCAACAATGAGCACATCTAGTGCCCA

TGGGGGGGTGGG GATCTTGGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11187078 10 94330685 GTCAACATAGATTTTGTGATTTAGGATM C/G CTGATTGCCTCAAATGTTTC I I I I I CACA SEQ 0408

AAACATTTTGAAAAATACGATTTTAGAATT ATGGGTTTGTTCAAATCAGGATCCAAACA CCACAGCCAAACAATGTCCATAAATAAAT AGAACAAAACACTTCATTTAATTAATATGT ACCCCAGGCATCCATTCATTATTCAGCTT TTCC I I I I I I IA I I I I G I I I I GTATC I I I I G CCATAATTACCAGTTCATGGCCAATATTG AAGATGATC I I I I I I GAAGAGTTTATTGA TTCTATCTTTTCCTCCAACTCCCTCAACC AGTATTGCAAACAGAAAAGTAAACAAGTG TCCACTAAATTATTCTGAACCAAATACCG ATAAGTGTACAGCTCAGTGAATTTTCAAA GGCATCATATTATTAATATTTCATCTCAGT AACTGAACACATCCCTGTAAACACACCCA ATTTCAGTATATGTCTCAAAGGACTTAAA GAAGCTCTGCCTTATTCTCCGTTTCAGTC GAAAATCCACAGGCACTAACATACTTAM ACTGTCACCCCAAGGGTAAACACTAACC ACATTAAGATAATTATTTAATATAATCAAA TGACTTCTAACACAATAAATTAGTTTTGC TATGTAGTCAGTGTTCCCACTTTCCTGAG CTGGATTACAGTTTAATATAAATGCACTC TGTTCCCACTTT ATACAGTATATACTCTTTTGGGTCTGGCT TTGTTTAACTATCTGGTGAGATTTATCCA TA I I I I I I AGAATAA I I I I I GTTTGTTCAC TTTC I I I I C I I I I CTTTC I I I I C I I I I I I I I I I I I I I I I I I I I I I I GAGACAGTCTCACTC TGTTGCCCAGGCTGGAGTGCAGTGGCGT GATTTCAACTCACTGCAACCTCTGCCTTT CAGGTTTAAGTGATTCTCCTGCCTCAGC K* CTCCCAAGTAGCTTGGATTACAGGGGCC CACCACCATGCCCTGCTAA I I I I I I I I I I I I I I I I IAGTAGAGACCGGGTTTCACAATG TTGGTCAGGCTGGTCTTGAACTCCTGAC CTCAGATGATCCTCCTGCCTCAGCCTCC CAAAGTTCTGGGATTACAGACATGAGCC ACCGCGCCGGCCTGTTTGTTTAC I I I I I I TTTTGAGATGAAGTCTCACTCTGTCAGCA GGCTGGAGTGCAGTGGTGCAATCTTGGC TCACTGCAACCTCCGATTCCCTGGTTTAA GCAATTCTGTCTCAACCTCCCAAGTAGCT GGGATTACAGGCATGCGCCACAATGCCC

Supplementary Table 3

SNP Chr Position 5 Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2421941 10 94335889 AAGAAAAACATGGAGGCTGGGCATGGCA OT ATTATGTCTGTTCATAGCTGAGCATTTCA SEQ_0409

GCTCATACCTGTAATACCAGGCAGGAGA TTCTAGTGACTAGAAATTTTGCAATGAGG

ACTGCCTGAACCTGGGAGGCAGAAGTTG CGGGGTGTGGCGGCTCATGTCTGTAATC

CAGTGAGCCAAGAGCATGCCACTGCACT CCAGCACTTTGGGAGCCCGAGGCAGGT

CCAGCCTGGGTGACAGAGTATGACTTTG GGATCACCTGAAGTTGGGAGTTTGAGAC

TCTCAAAAAAAAAAAAAAGAAAGAAAGAA CAGCCTGGCCAACATGGTGAAACCGTGT

AGAAAGGAAAGAAAGGAAAAGAAAAGAA CTCTACTAAAAATATAAAAATTAGCTGGG

AAACGTGGAAATGTTTTATAAAGTTAAAT CGTGGTGATGCACGTCTGTAATCCAAGC

AGTTCTAAAAGGCTTGTAACAACAACAAC TACTTGGAGGCTGAGGCATGACAATCGC

AAAAAAAGTATTTTCTCAGCCTTATTCCA TTGAACCTGGGAGGTGGAGGTTACAGTG

CACCAATGCCTCTAGACCTTTACCCCAG AGCCGAGATTGCACCACTGCACTCCAGC

AAACAACCAACCACTTTAGTTG I I I I I GC CTGGGTGACAGAGCAAGACTCCGTCTCA

TGGCATTTACACATTTCTATTTTCATAAG AAAAAAAAAAAAAAAAAAAAAAAAAAAAG

GAATTTGTATATACTGTTATTTGTATTTAT AAAAGAAAAAAAGAAAGAAATCTTGCAGC

TTATTTATTTATTA I I I I I I I GAGACAGGG TGGGCATGGTGGCTCACGCCTGTAATCC

TCTCACTCTGTTGCCTAGGCTAGAGTGC CAGCACTTTGGGAGGCTGAGGTGGGTG

AGTGGCTCTATCAGGTATCACTGCAGCC GATCACGAGGTCAGGAGTTCGAGACCAG

TCAACTGCTCCCATTGAAGCAATCCTATT CCTGGCCAATATGGTGAAACCCCATCTC

GCCTCAGCCTCCTGAGTAGCTGGGGCCA TACTATAAATACAAAAATTAGCCGGGCAT

CAGGCACATGCCACTACACCTGGCAAAT GGTGGCGCGTGCCTGTAGTCCCAGCTAC W

TTTTTTCTATTTTTTGTAGAGACAGGGTCT TTGGGAGGCTGAGGCAGGAGAATCGCTT K>

CACTTTGTTGTCCAGGCTGGTCTTGAACT GAACCCGGGAGGTGGAGGTTGCAGTGA

CCTGGGCTCAAGTGATTCCCCCACCTTG GCTGAGATCGTGCCACTGTACTCTAGCT

GCCTCCCAAAGTGCTGGAATTACAGGCA GGGGCAACAGAGTGAGATGCTGTCTCAA

TGAGCCACCGCGCCTGGCCCTTGACCTC AAAAAAACAAAAAACAAAAAAAAGAAATC

CTGGGTTCCAGCAGTCCACTTCCACCTC TTGCAATGATGTGCCTTGGTGTGCATCTA

CTGAATAGCCTCAACTGCATCAGTTGAA CTTTCTTTCTTTC I I I I I I I I I I I I I I GACA

GTGATCTTACTGCCTCAGCCTCATGAGTA CGGAGTCTCACACTGTCGCCCAGGCTGG

CCTGGGACTACAGGCACACACCACCACA GTGCAGTGGCGCAATCTTGGCTCACTGA

CCCAGTAATTTTTAAAGTTGTTCATAGAC AAGCTCCGCCTCCTGGGTTCACGCTATT

ACAGGGTATTGCTTTGTTACCCAGGCTG CTCCTGCCTCAGCCTCCGGAGTAGCTGA

GTCTCAAGCTGCTGGACTCAAGCAATCC GACTACAGGCGCCCGCCACCACGCCCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs6583826 10 94337810 AATAAAAATCAATTTAAAATAGTTTATTCG A/G ACATTTCAGGGACTGCTTAGTGCAACAAA

AGAAGTACATATACTCCTGAAAGAGAAAT ACACTTACATGGGGCCATTAGACCCTAA GCCAGAGCAAACACGTGGGCAACGATGT CTATCTCTATTAGACTTAGCCCTGAGGGC TGCATTGTTAGAATTCAGTTTAACTAGAC AAGTACAATAATTCAGCCTGTATATTCAC TTAAATTATTATTATTATTATTGAGACGGA TGCCAGGCCCACAGTAAGCATTTCAAGA GTCTTGCTGTGTCGCCAGGCTGGTGTGT AGAGTATGAGAAAAGTGGATGTGACCAG AGTGGCGTGATCTCGGCTCACTGCAGCC GCATGGTGGCTCATGCCTGTAATCTCAG TCTGCCTCCCAAGTTCAAGTGATTCTCCT CACTTTGGGAGGCTGAGGTGGGTGGATC GCCTCAGTCTCCCGAGTAGCTGGGACCA ACGAGGTCAGGAGTTCGAGACCATCCTG CTGGCACACGCCACCATGCTAAA I I I I I l GCCAACATGGCGAAACCTCGTCTCTACT I I I I I I I I I I I I I GTA I I I I I AGTAGAGAC AAAAATACAAAAATTAGCTGGGTGTGGTA AAGGTTTCACCATATTGGCTAGGATGGT GCGCGTGCCTGTAAACCCAGCTATTCAG CTCAAACTCCTGACCTGGTGATCTGCCC AGGCTGAGGCATGAGAATTGCTTGAACC ATCTTGGCCTTCCAAAGTGCTGGGATTA CGGGAGGCAGAGGTTGCAGTGAGCCAA CAGGTGTGAGCCACCACACCCGGCCCC GATTGTGCCACTGTACTCCAGCCTGGCG AGCTAATTTGTTTGTTTTGAGATGGAACC ACACAGCAGTACTCCATCTCAATTAAAAA TCGCTCTGTTGCCCAGGCTGGAGTGCAA AAAAAAAAAGAATACATGTGCACTTAGCA TGGTGTGATCTTGGCTCACTGCAACCTC AATGAAAAAAACTCAATG CACCTCCAGGGTTCAAGCGATTCTCCTG CCTCAGCCTCCCAAGTAGCTGGGATTAC

K* AGTCACGTGCCATCACACCCAGCTAATTT TTGTA I I I I I AGTAGAGATGGGGTTTCGC CATGTTGGCCAGGATGGTCTCGAACCCC TGACCTCAGGTGATCTACCTGCCTTGGC CTCCCAAAGTGCTGGGATTACGGGCGTA AGCCTCCGTGCCCAGCCGAGAAATGTfG ATTATTAGGCTGAGTAGTTTGAACTCAAC AAAGGCAATGTAAAAT rs3824735 10 94344184 GTTTATTACATTGTTCTTAATAAC I I I I I G A/C GCCCCAGAGTACAACAACTAGTAAGTGT SEQ_0411

TAAGTCTGAAATATTTTGTAACTMCATTA CACTGGCTAGACTTAAGATTGCCACCCA AAAAAGAAATTAAATAAATGCATACGGAA ATTTCCTCTCTGACACCTTGTTTAGAAAC AAGGTAATATTGCCTGGTTTTATTAAACA CTAGTCATCACCTTCGATATCCACAATTC ACCAAAATAATTTTAAAATTTGCACTTGTT AAGTTACCAGGGCTGAGTAAACAATAGC ATATGCACTGCA I I I I IAAATAAAAATCTT CTAAGAAAGTTTGTTGATACAAG I I I I I C CAAACAACTAACTACTAACAGA TAAAAAATAACCTTTTAATTTTAGAATAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10786050 10 94357210 GTGACTGAAATTTAACTGTATAAAACTTG A/G GTCTATTTATGACAGAATGGTTGGAGCA SEQ_0412

TTTGAGGGCCTCTGTCTTGGAATAGAGA GAATATTGTAGAAAAGTTGGAATATGAGT

TCAGAGTACCTATGTCAAAATGAACTTAG GAAGCTTGAAGGCAGGGAGGGCTTTGTA

GATAAACCACTACTACAGTAAAATTAAAG TTGAAGGAATGGGTCTCAGAAAGTTAGC

TGCATGGTATGACTCCTGTTTAAGAAACA ATGGCCAGGGGAAGTATAGTACTTTATTC

GCCTCAATGGAAGAGGAAGGACCAATAT ATGATGATCCTAAGTGTTCAAGAAATTAA

ATATGGCACAGTTATATGATAAAAGAGG GATGAATGTATTGTTTAATATTGCAGAAA rs11187096 10 94359568 CCATTTTCTTTTAAGAAGAATTAGGAACT G/T GTTGAAGCAATTCTCCTGCCTCAGCCTCT SEQ_0413

TGGAGAAAGTCAAATTGGGGTGGGTCΛG TGAGTAGCTGGGATTACAGGTGTCTGCC

GGTATGTGGGTCACGTACCTAGAGTTTG ACTACGCCCAGCTAA l I I I I GTA I I I I I G

TGTTATAAGGAGGGGTCATTGGTAATTG GTAGAGATGTGGTTTCACCATGTTGGCC

GCTTGAGATTTATATGGAAGGAACCAATA AGGCTGGTCTCGAACTCCTGACCTCAGG

TTGGAAGAATGTTGAAAGGAGAACAAAG TGAACCACCTGCCTTGGCCTCCCAAAGT

ATAAGTTGAACCATAGCTGAAGTATTAAA GCTGAGATTACACGTGTGAGCCACGGCG c i i i i i i i i ci i i i i I GAGACGAATTTTCG CCCGGCCTAAACTTTTTTAAAGTAGAAGA

CTCTTGTTACCCAGGCTGGAGTGCAGTG ATCCTTTTATTCTAGTAACATGATATATGG

GCGCGATCTTGACTCACTGCAACCTCTG AAGCCCAGGATAAAATGTGGCTGCTATA

CCCACCG GTTGATTTTGGAATGGGACGCTCTGAGG

CTTACCTCCTTAGCCTTATGAAGGGGTC W

CCTGAGGCACTTTTGTGGAGCCCCCTAC £

TGATATTAGAATATAGTTTGAAAACCCTT

GCATTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7914814 10 94372930 GTATATTTCTGAAGAAAATTTTAGGTAAG CfT TCTTGCTAATTCACTGTAGTCACACTCAC SEQ_0414

CCCTTGGCTATGGAGTTAATTTCCAAGAA CTCATCTTTTCCATGATTCCTAACCCCTG

TAAGCATTTCTGATAACAGGCTATTTGAA GCAACCACTAATCTGTTCAC I I I I IAAAG

GTAAAACTTATGTAGCAGTAAGTAAAATC CCCTGGAGTAATTTGTTCAAAGGAAAGCT

TTTATATCCAGTGCCGATAAATACTTCAT TTTATTGAGGCCCATTGTATAAAACAACA

TTTGTGTGTGTGTGTGTTTTCTTTTGAGA ATAATAACAGAGAAAACAAGGGGAAGAA

CAAGGTCTCGCACTGTCACCCAGACTGG GGCAAGTGGGATGCTAAGGACTATAACT

AGCACAGTGGCACAATCTTGGCTCACTA TGAAAATTCCTGATTGTGTTTATCCTTGA

CGTCCTCAGTCTCCTGGGCTCAAGCGAT AGATATTAGGAAGCAAGACTTTCACAGA

CCTCCTGCCTCAGCCTCCCAAGTAGCTG GCA I I I I I I AAAAGTTAA

GGATTATAGGCATGAGCCACCACACCCT

GCTAA I I I I I GCA I I I I I I I GTAGAGACA

GGGTTTCACCATGCTGCCTAGGCTTCTA

TTTTGTTTTGACATTAACAAGTAGCTATCA

AACAC I I I I I AAAAATCTTTTACTAACTTT

TAAl I I I IAAATCATTAATTCATGTGAAGT

TTCAAGAAGAGTACAAGAGAGGTTTCAT

GTATTCTTCACCCAGTCTTCCTCAGTGGT

TATCTCTTAAATAATTATAGTACAAGGCT

GGATGTGGTGGCTCACACCTGTGAATCC S

CAGCACTTTGGGAGGCCAAGGCAGGCA ^rj>

GATCACGTGAGGTTGGGAGTTTGAGATT

AGTCTGACCAACATGGAGAAACCCCATC

ACTACTAAAAACACAAAATTACCCTGTGT

GGTGGTACATGCCCGTAATCATAGCTAC

TCCAGAGGCTGAGGCAGGAGAATTGCTT

GAAGCTGGGAGGCGGAGGTTGTGGTGA

GCCAAGATCGCGCCATTGCACTCCAGCC

TGGGCAACAAGAGTGAAACTCTGTCTCA

AAAATAAGTAAATAAAATAATAGATAAATA

AAAAATAGGCGCGATAAATAAAAAATAGG

CTGGGCGCCGTGGCTCACGCCTGTAATC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10882095 10 94384382 GGCTAA I I I I I I GTA I I I I I AGTAGAGAT GfT GTATGGAACTAACTTTTGAAACC I J I I I C SEQ_0415

GGGGTTTCACCGTGTTAGCCAGGATGGT ACTCATGTCTTGTAACATTAGGAGTAGCA

CTTGATCTCCTGACCTTGTGATCCACCC GTTATTAGTGAGGCTTCTAATGACTAAAG

GCCTCGGCCTCCCAAAGTGCTGGGATTA GGCAAGTTTAGCACCACATGATATCAAG

CAGGCATGAGCCACCGTGCCCAGCCAG GGACTTGTTAGTTGGCCCAGAAATTGGC

CCTCTCCTTTTCTTTATTTGTATTTATTTAT AAGTCACTCTTTCCCCAGGGGTCCTGGA

I I I I I I CAGCCTCTCCTTTTCTCGGCTCA CCCAACCAGAAGGGGATATTGGGTAGCT

CTGCAACCTCTGCCTCCTGGGTTCAAGC G

AGTTCTCTTGCCTCAGCCTCCCGGGTAG

ATGGAATTATAGGCATGTGCCACCACGC

CTGGCTAATTTTCGTA I I I I I I I I IAGTAG

AGATGGTGTTTTACCATGTTGGTCAGGCT

GGTCTCAAGCTCCTAACCTCAAGCAATC

CACCCACCTCGGCCTCCCAAAGCGCTGG

GATTACAGGCGTGAGCCACCGTGCCCG

GCCGAGAGTACGTTTATA I I I I IAAAGAC

AGATCTCTCCACTGTTTATTCTCTCCCAG

AAAGATTATTTTCAAA rs7900689 10 94385728 CAGCACACGCCTGGTGGGACAATCAGAA A/C TTAGATCAGGA I I I I I I I I C I I I I I ATAAA SEQ_0416

CACAACGTTTATCAGTTACATTTGCTGTC TATTTCCAATCTATACTACATTCTTAATTT W

TTATAGGGGTACAGTTTATGGTACCCCAA CCCTATTTCTTGACAAGAACAACATCTTT O^

GACAATTACAATAGTAACATCAAAGATCA CACAAGTTCTTCTGATACMTAGGATGTA

TTGATCACAGTGTATAATGAAAAAGTTAG AGTCATCTCAGATCTTCAAAGTTAAGTAC

AAATACTGTAGTAGTTACCAACATGTGAT TTCCAGCCCAAGGGCTAATCTTGATGAC

GCAGAGACAGAAAGTGAGCACATGATAT TACTTGGTCTCAGCC I I I I I GACTG

TTGAAAAAAGTCACTGATAGACGTGCTCA

AGGTAGGGTTGCCACAAACCTTCAATTT

GTAAAAATTTGGTATCTGTGACACATAGT

AAGGTGAAGCACAATAAAATAAGCTATGC

CTGAATTGATACATTTCTACTTACCAAGT

TACAATTTTTGCTTGAATTAAAAGAAAAG

AGGCATGTTGCTCTCACAAAATTAGTTGA

AATTGGTATGCTAGCTCTTCTTTCCAAAA

GAATGTCAGTAGACCTATAAGTATTTACT

AATGTATTTCTGTTATACTTCCTCAGCCC

TATCCTACCAAAAGGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6583830 10 94388098 ATAAATGTAATTCATGATTTATCTTCCCTG A/G TACTACCTGAAAAGCATCCATGTTTGAGT SEQ_0417

TAAACTGTTCCTCATTATATGAGGCTTTA GGCTCTTTTGTGTG I I I I I I GGCAACTTA

AACCAAAACCAAGCCTTCAAACCATAATC AAACTGCAGCATTTTCTCATACATCTACA

TGTAAATATCAGATATCTGAAAAACAGCT TAGGGTATTTCCCTTAAACCCGTTGAGAA

TCTGGTATTCTTAAGACTTTAATAATGACT C I I I I IAGGTGTATATTCTAAGGCTGATC

GTCTAAAGTTTTATTAAATGAGCTTATTAT CCC I I I I I ATAAATTTGCTGTTTTGAAATG

AATATGACAGAACTCTTATAATAGTTAAC CTTAAAATTGTTAGACAGCTCTTTA

ATTTATTGAGCAATTCACTGTGTTTATTCC TCCCATCAATATAGATATAAATTCTATTAC TAGTCAGATTTTTAATGAGGAAACTGAGA CCCTGTGAGCATCTAATAGTATGTAGATC ATCTTGCAGAAGGTGGTAGTGATC

1»

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS10882096 10 94391366 TATACTCATGAGGAGAAAGATACTATATT GfT TTGAGTTTATTCTATTTGGGTTTTGTTTAG SEQ_0418

TACCCTATTΠTCCCCATTTAATTCTGAAA CTTCTTGAATCTGTAGGCTTATGCCTTTC TTAAACTTCCTAAAGTTTCAAGCTTTCTTT ACCAAAACTTGGGAAATTTTCATCTATTA GGTGGGAAGTAGTCTTTAAGGGTGGGTC ATTCTTTGAATATTTTTCAGCCCTATACTC TGCTGGACAGAAATTG I I I I I CTTTGTCT I I I I I CATCTGCCCCTATGACTTTGATGA AAGAATGTCTTGATTTCCCCTTCATTCCT CACAAATGTTAGATCTTTTATTTTGGTCC GAAAGGTATTTTCACTGGCTGTGGAATTC CTCAGGAGATATGTAGAATATATTTCTTA AGGGTTGACAATTATTΠTTTCCAGCATT TAGATACATATATTCTCTTTGTTGTTCACA TGAAATATTTCCATTTTCTTCTGGCCTCTA TTGGGGAAATTCTATTGATCTGTCTTCAT TGAAATGAGAAATCCACTGCCATTCAAGT ATTCACTGAGTCTCCTTCTGTCATCTCTA AATTGTTCCCTTATAGGCAGTCTCCCTAT ACCTACTGTTAAACCCATTCAATGAGGTG AGCTGCTTTCAAAAC I I I I I I GTCTTTAGA TTTTTTCAGTTATTGCTTTTTTATTTTTAGT AACTTGATTATATTTTGTCTACTTATATTT TTTATAATTTTCATTTGC I I I I I I IATACCT

C TGTTTCTTAGCTAGGA I I I I I I I CTTTTCC AGGAGTATTTTAATTTCTTTTTGGAGCATT TTTTGATGGCTGCTTTAAAATCCTTGCCA GACAATTCCAACATCTGAGTTTTCTTGTT GTTGCCATCTATTGATTGTCTTTTCTCATT CAACTTGTGA I I I I I GTGGTTCTTGATAT

ATGATAAGTGATTTCCTATTGTACCTTGA K* AGATΠTGGGTATTATGTTAGGAGATTCA GGATCCTATTTAAGTAI I I I I IAGCTGGC

ATTCACCCTGTTTAGGCTTAGCATACAGA

TCCAGGCTCACTTTTATGGGCTGTGGTT

CCACTGACAATTTAG I I I I I AGAGCCCTT

GCAGTGTTATTCTGATAATGCTTTGTTTG

TGTGCTACCCACATGAGAAAAATTTGTAT

TCTGCTTTTGTTGCATGAAGTGTTCTGTA

TGTGTCACTTTGATCAAGTTGATTGATAG

TGCTATTCAGGTCATCCACGGCCTTACT

GAGTTTCTGCCTATTTGTTCTATCAGTGA

CTTAGAGAGGAGTATTGAAATCTCTAATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11187114 10 94396217 ACATTCAAACCTATTATTATTTTAAGTATT A/T GCTGTTTTCACTAAAAGGAACTAGAGTTT SEQ_0419 TAGGTTATTGTTCTGGTAACTAAAGGATA GTATACAAATAGCTAATTTCAGATTTGTG CTTGATAGGTTTATGGATTTGCTTGAACT ATAGGAAATGTATAATATATGAGCCTAGA TAACGCTTGCATGAGCCCTTTGTAACTTG GATCTTGTCATACCAGAGAGTAAGGAAG G I I I I I I CTTTCTTTGCATTAATAGGATTT CTGTTAAAGATTTCTGAGGTTGTCAAAAG TACTAACATTCTCAGGAAGTAGGTACAAA GTCTTAGTAGCCAACCTCCCCATCTTCAA GAATTAAAA I I I I I AATCTATATA AGGTGGCATAATTTGAGCATCAAAAAGAA TAATGGCCATAATGGATTAAAACATATCA AATATATTAAAACTTACGAACTCATAAAAA TTTCATAGGTCTCCTTTGGATCATGCTAG GGAAGCAACACATTGTCCTGAAAATGGG TAAAGAAGAAGAAAAAATTTAGCATCCAT CTGTCTTTCCTAAAAGAACCATATCTTGG TTTAGCAGGGTAATGAAGAAAAGTGTTTC ATTAGACTCTAAGCTAATAAAATGGAGAA GAAATGATAGAATTAATATATCACCAGTA TGCAACTCTTAATAAAATAACCCCTGTGG ATGTTAATGATGGCTTAAACCATTTGATC AAAAGCTGTTGGGGAACTTTATAATTAAT AGGCTAACCATACCTGAACTCACTGATAA κ> A rs4933734 10 94₄0₄547 TTCAGTAGTCAGAATTTTATCTAGAAATC A/T AGAGTATACATTGCTATTATGGGAGACCA SEQ_0420 TTTTAACACC I I I I IAGTGGTTATTTCTAA CCCAGACATCTGACTAATGGCTCTGTGC AATCACTGTCAACAATAAATCTAACCCTA CCACACTCCAAGACCTGTGCCTTTTAGA GTTGTATCCCTCCTTTCAGTAI I I I ICACT GAAGCTCACAATGATTTAAGGACTGTTTG TGTTGCCCCAAATGTGAAAGCATTTCATT AAACTTCCAATTATGTCTATAATTTATATT CCTTTAAGAGGCCTAACTCATTCACCCTG CTTTTGTTTACATGATGAAAC I I I I I GTTG ACAGAGTTCACAAAAAGCCCACTT TTGCTTGTTTGTATATAATACAATGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2185756 10 94420477 CCCTCTAGCAACCTAGCCGCCCACCACA G/T I I I I I I I GAGACGAAGTTTCGCTCTTGTT SEQ_0421

CTACTGAAAACCAAAGAGAAAGAGAAAAT GCCCAGGCTGAAGTGTAATAGGGCAATC

TTTGAAGACGACCAAAAACAGAAGACAC TCAGCTCACTGCMCCTCCGCTACCCAG

ATTAAATGCAGAGGAACGAAGATAAGAAT GTTCAAGCGATTCTCCTGCCTCAGCCTC

TATACCAGG I I I I I CATTAGAAACTGTGC CCGAGTAGCTGGGATTACAAGTGCCTGC

AAACCAGAAGACAATAAAGTGACATTTAA CACCATGCCTGGCTAAATTTTTGTATTTT

AAAATATTGAAAAAACCCACTTTTAACCA TAGTAGAGATGGGGTTTCACCACGTTGG

GAGTTCTATACTCAATGAAAATACTTTTC CCAGGCTGGTCTCAAACTCTCGACCTCA

AAAAATGAAGGCAAAATGAATACTTCTTT GGTGATTGCCCGCCTTGGCCTCCCAAAG

AGAAAACAAACCTAACAATTTATTACCAA CGCTGGGATTACAGGCATGAGCCACTGC

CAGTCCTGTACTATAAGCAATATTGGCCA GCCCAGCCAATAGTC I I I I I I I I I I IAATT

GGCACGGTGGCTCCCGCCTATAATCCCA AAAATTTTTTAAAAAAGAAAATAAGTAAAT

GCACTTCGGGAGGCCGAGGTGAGCAGA AGTGTCCTATCATATATTAAAGAGGCATC

TCACCTGAGGTCGGGAGTTCAGGACCAG AATATTGTTCGTAGAATTAATTAGCAGAT

CCTGACCAACATGGAGAAGCCCCATCTC ATGAAAAAGTTCTTAAATGTTACAATTTTA

TACTAAAAATACAAAAATTAGCCAGGCGT AAAATATTGTGCACCCATAAAATATAGCT

GGTGGTACATGCCTATAACCCTAGCTAC GTTTACACTCCTTAAAAAAAGAACCTGGT

TCGGGAGGCTGAGGCAGGAGAATCGCT ATACGGGCCGGGCGCAATGGCTCACGC

TGAACCCGGGAGGCAGAGGTTGTGGTG CTGTAATCCCACCACTTTGGGAGGCCGA

AGCCGAAATCACACTACTGCACTCCAGC GGCGGGCGGATCACGAGGTCAGGAAAT W

CTGGGCAACAAGAGTGAAACTCCATCTC CGAGACCATCCTGGCTAACACGGCGAAA O

AAAAAAAAAAAAAGAAAGAAAGAAAGAAA CACTGTCTCTACTAAAAATACAAAAAATT

AGAAATGTTAAAGAGAGTTCTTAGGCCA AGCTGGGTGTGGTAGTAGACGCCTCTAG

GGCGCGGTCGTTCACGTCTGTAATCCCA TCCTAGCTACTTTGGAGGCTGAGGCAGG

GCACTTTGGGAGGCCAAGGTGGATCACT AGAATCGCTTGAACCCAGGAGGCAGAGG

TGAGCCCAGGAGTTTGAGACCAGCCTGG TTGCAGTGAGCCGAGATCCTGCCATTGC

GCAATATAGTGAGACCTTGTCTCTACAG ACTCCAGCCTGGGCGACAGAGCAAGACT

GAAAAAGAAAAGAATTAGCCAGGCATGG CCATATAAAAAAAAAAAAAAACAAAAAAA

TGGTGCACACCTGTAGTCCCAGCTCCTT AAAACCCTGATATACAAGGAGATAGCCC

GGGAGGCTGGGGTGGGAGGACTGCTTG TTGATCCAAAAC

AGCCCAAGAGGTAGAGGCTGCAGTGAG

CTGTGATCATGCCACTATGCTCTAGCCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7911264 10 94426831 AGTCTGGAGCTTCTCAGGACATTCATTTA C/T AATATTTGCTAGAGAAATGCTCTAGTTTA SEQ_0422

CCAATACCATTATAACAAAGCTCTTTGAG CCATAAAAGAATTAGAAGAGCCCCTTGA

GGCAGGAGCCTTGTCCTATTAATATTTAT GCTACTTTTCTCCATTATCATTATTGTAGT

ATTCTCCACTAGATATTTATATCTAGTATG TGTCATTGGTATTATCATTATTATCATTAC

ATAGACCCTGGATAAATTTCTAACTGAAA CATGGCAACCACCATTTATTAAGTGCTTA

ATCTCCCTATAATAACAGATTTCCAAAAT CTCTATGCCAGTGATTGACATGCAACAAC

CCAGACAAGGCACATTTATTTCAAG TCATTTTATCATCACAATACTATTATGAGA

AAGATATTACCATCCCTATGCTACTTAAA

GGACACTGGGGCTCGAAGAAGTTAAGAA

ACTAATCAGGCCGGGCTTGGTGGCTCAC

ACTTGTAATCCTAGCACTTTGGGAGGGT

GAGGCGGGCAGATCTCAAGGTCAGGAG

TTCAAGACCAGCCTGACCAATATGGTGA

AACCTCGTCTCTACTAAAAATACAAAAAA

TTGGCTGGGCGTGTTGGCACACGCCTGT

AGTCCCAGCTACTCGGGAGGCTGAGGC

AGGAGAATCGCTTGAACCTGGGAGGCAG

AGGTTTCAGTGAGCCAAGATCACACCAC

TGCACTCCAGCCTGGGCGACAGAGTGA

GACTCTATCTCAAAAAAAAAAAAAAAAAA £

AGAGGAAACTAATCAAAGCACACAGTAA ^

AATTGGTGGGACTTGAATTCAAAATCATG

TTTGCATTTGACCCATTATTGGGTATATA

CTCAAATAAATAGAACTCATTCTACCATA

AAGACACATGCACTTGCATGTTTGTTGCA

GCACTATTCACCATAGCAAAGACAAGGA

ATCAATCCAAATGTCCATCCTAAGTAGAC

TGGATAAAGAAAATGTGGTACATATACAC

CATGGAATAGTACACAGCCATAAAAAAGA

ATGAGATTATGTTCTTTGCAGCAACATGG

ATGGAGATGGAGGCCATTACCCTAAGCA

AACTAATGCAGGATCAGAAAAGCAAACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2488087 10 94436021 TTTAAAAAACTATAAAGGAGCCGGGCGC CH^" GCTCCATTCATTGCCCAGGCATGTCTCG SEQ_0423

GGTGGCTTACGCCTGTAATCCCAGCACT ATCTACCGGGCTCAAGCTATGCTCCTGC

TTCGGAGGCAGAGGCGGACGGATCACG CTCTGCCTCCCTAAATGTTGGGATTACAG

AGGTCAGGAGATCGAGACCATCCTGGCT GCATGAGCCATTACATCCAGCTATGTAAT

AACACGGTGAAACCCCGTCTCTACTAAA ATTCTAAATCCTTTGTTGTCATTTCAATAA

AATACAAAAAATTAGCCAGGCGTGGTGG TGTTCACAGCATATTCACCAGAAGTAGAT

TGGGCGCCTGTAGTCTCAGCTACTCAGG TCCATCTCAAAAAACCACTTTCTTTGCTC

AGGCTGAGGCAGGAGAATGGCGTGAAC ATCCATAAGAAGTAACTCCTCATCCATTC

CCGGGAGGCGGAGCTTGCAGTGAGCCG AAGTTGTATCATGAGATTGCAGCAATTCA

AGATCGCCCCACTGCACTCTAGCCTGGG GTCACATCTTCAGGCTCCACTTCTATTTC

TGACAGAGCCAGACTCTGTCTCAAAAAA TCTTGCTGTTTCCAGCACATATGCAATTA

AAAAAAAAAAAAAAAACTATAAAAGACAT CTTTCTCCACTGAAATCTTGAACCCCTCA

TGC I I I I IATTGGGGGGGGGGATAATGG AAGTCATCTGTGAGGGCTGGAATCAACT

GGACAAACTATGAAGTATATGTTAGTTGA TCTTCCAAACTTCTGTTAATGATA I I I I I A

CATTATTAATCTTTTAGATGTGATTGGTAT CCTCCTCCCATGAATCATGGCCTCTGGA

TGCAGGTTACTTTGGAAAATGCGATCTTG ATGGTGAATCCTTTCTGGAAGGGTTTTAC

GGAGTTGCAAGCTAAAGTCTTTAGGAGT TTGACTTTGCCCACAGAGGAATCACTATC

GATGGGTCATATGTGCAGCTTACTTTTAA TATGGCAGCTATAGCCTTACAAAATATAT

ATACTTCAGTATATACATATATGTGCATA TTCTTAAATAATAAGATTTGAAAATCAAAA

CACATCTACATGTATATTTATACACACATA TCACTCTTTGATTCATGGGCTGCAGAATG W

TCTATGTATATGTTCATATATGTATATATA GATGTTGTGTTAGCAAGCATGAAAACAAC tJ

AAGAGGGATATATCACAGGTTCAGTTCTA ATTCATCTCTTTGTATATCTCCATCATAGC

GACCACTTCAATAAATAAACATAGCAATΛ TCTTGGGTGACCAGGTGCATTGTCAATG

AAGCAAGTCACATGAATTATTTGGTTTCC ATCAGTAATAATTTGAAAGGCATATTΠTT

CAGTGCATGTAAAGGAGGTTATCTTTACA TCCTGGGCAGTAGATCTCAACAGTAGGC

CTTTACTACATTCAGTGTGCAATGGCATT TTAAAGTGTTCAGTAAACCACACAGTAAA

ATGTCTTAAAAAGCAACGTACATACCTTA ATGATGTGCTGCCATCCAGGCTTTGTTAT

ATTTAAAAATACTTTGTTACTAAAAAATTG TTTATTTATAGGGCACAGGCAGAGTAGAT

CTAACGATTGGCAGGGAGTGGTAGCTCA GTAGCATAGTTCTTAAGGGCCCTAGGAT

TGCCTGTAATCCTAGCACTTTGGGAGGC TTTCAGAATGGCCAATAAGCATTGCTTTA

CAAGGCTGGCGGATCACTTGAGGTCATG AACTTAAATGTCAGCTGCATTAGCACCTA

AGTTGAAGACCGGCCTGCCAATATGGTA ACAAGAGAGTCAGACTGTCCTTTGAAACT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10882100 10 94450667 TTTAAGCCAAGATAAGCAATAATAATAAC C/G CTGTTCCACGGAGAAGGATGATCCTGTA SEQ_0424

ATAGTCCAGGTACAGTGGCTCATGCCTG CACAGGTCTGGAGGTGAAAGAGGGCAG TAATCGCAGCACTTTGGGAAGCCGAGGC GGAGTATGCATGACTGGACTCCAGAGAT AGGCAGATGGTTTGAGGTCAGGAGTTCA TTTGGATTTCAGAATTTTCAGTGAGGGAT AGACCAGCCTGGCCAAAATGGTGAAACC TGTGGACCTGTGTTCTCTCTACCCACCA CCGCCTCTGCTAAAACAAATACAAAAACT CACAGGTCTCTTTG I I I I I GCATTGGCAC GGCAGAGTGTGGTGGCAGGCGCCTGTA TTTCCTCTCTCTGGAACTCTCTTTCCCCC ATCCCAGCTACTCGGGAGGCTGAGGCA AAATATAGCCTCATGGCTTGCTCCCTCCT GGAGAATCACTTGAGCCACTGCACTCCA CTCCTTCAGACATGGCCTTCCCTTGCCA GCCTGGGCGACAAAGTGGGACTCCGTCT CCTTTTTACAATGCCAACCTCCTCTTCCT CAAAAAAAATAAAAAATAAAAAATAAAAM ATCCCCAACAACAATTTAATTTTCTCTATT ATAAAATAACATAAATAGAAGAGTAATAA TCACTTAATGCAATTGGATATAATA I I I I I TCCCTGTGTCTCTAGGGTCCAGGCGCTC ACTGCCTTATTTATTATGTGTCTCTCCTTA AGTAGCACTGGAGTGTAATGGAGCTGAC TTGACATATGAACATCATGAGGGTAGGG AGAGAGAGATGCTGCAATAAGGGATGGA A I I r I I GTCTGTTATGTTCACTGTTATGTA CAGCAGATGCTGTGGCAGAGTCTGCCAG TCTTCAGCCTGACCTATTAGGTGCTTGTT GGACTCCCAACCAGAGAAAAGGAAAAGG AAACATATGTTAAATTAGTGAATTACTGA AAG GCACGTACTA rs11 1 1875 10 94452862 GCTGCCTCAGGCAAATGGTACTTAGGTG A/G GACGTCTGAACCTGCACTCAGGGTCCAT SEQ_0425

ATTTTAAAGACCTTAATGAGATCAGGTAA I I PT IAAACATTTATTGAATTAGTCTGGTC TTGCTTGGTGAAGCTAAAAATTTTACCTT TAATCTACAATTAATGGAAAGTCTGTAGT CAATTAACTGATCAACAGCACCATACATC AATGCAGTTTCCATAAGCAGCTAAGGAAA ATCATAACTTCTCACTCCCTTCCACCTCC GTTGAAACTTTGAAAGAGCATGTAAAGTA GTACCATCAAGTCATTTCCTCT AACACTTTCTCTTCCTTCTACACTTCTTTG CAATTCATAAAATACTTTCAGAAATCATTT AAAAAATTTGGATTTCCTGCTTCCATTTTC TGAATAGATGATGCTGATAAAAATAGTAG TGATCACAGCCCATCCCAAATAGTGTCAT I I I I I I I I I CAGTAAACTGGATATATTTTA AATAAAACTCTTGATTGAAATTGAGAAGT GTGAACTGGAAATTGAATGAAATTGCCAA GTCTGAAAGGGAAAAATGGCCAATAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12778642 10 94454287 TGAAAATGACACTGCTCACATTTTACTGG G/T AGGCCGGGTGCGGTTGCTTATGCCTGTG SEQ_0426

ACTCCAAGACTCCTAGGTGGAGAGAAAG ATCCCAGCACTTTGGGAGGCTGAAGCAG AAAGACAGCAGAAAGAGCAGGAGCATCA TTGGATCACTTGAGGTCAGGAGTTCGAG GGCTGTCAAGAAACAAATCACTGCAACC ACCAGCCTGGCCAACATGGTGACACCCA TTTCACATATCAGAAGGGCTGGGAATATC TCTCTACTAAAACTACCAAACAACAACAA AGTAACCAATATCTCACTTA 1 1 I I rCCCA CAATAACAACAACAACAAAACCCCTAAAA CTCAGGTGGGTTAAATGAAAAAAATCACC ATTAGCTAGGCATGGTGGCAGGTACCTG TAATCCCAGCTACTCGGGAGGCTGAGGC AGGAGAATTGCTTGAACCTGGAGGGCAG AGGTTGCAGTGAACTGAGATCATGCCAC TGCACTCCAGCCTGGGCAACAAAGCAAG AATCCATCTCCAAAAAGAAAAAAACAATT TCTAAAGACAACTTCAATTCTGGACATAG GTCTCCCTGTAGTTACAGTATTTTATTTC AGTAGTTTTAGGAATTTAGTTTGCATTCT ATTCCACTTTCATTTTCCTGTTACTTTGAT GTTTAAAATTATAAAGCTGCTATGGGATG ATGTGCTGGATTTTA rs5015480 10 94455539 CTGCCTTGGCCTCCCAAGTGCTGGGATT C/T GTTTTCTATCAAATTATTCAAGTATTCATT SEQ_0427

W

ACAGGCGTGAGCCACCGCGCCCAGCCT CAGAAAATATTTATTGAGCACCTACAATG W AGGTCA I I I I I AATGTTGCACTTAACACT TGGCACGTGGAAGCACTGGGGATATAAA AAGACGCTATG I I I I I CTGTTCTATATCTT TTTGCATAAGGCTCAGTAGGATGACTTTG TCTAAGCAACATATTCACCCCTAAACTTC AAGACCAGAGAAAACATCCTTTTAATTTC AGTGGCTATGTGTTTTAGGTGTTGAGAG CAACATTCAAGGATGAACCTATTTTCACC GAATGAAGAATCTTTTATTTCACCGGTCT CTAAGCATAATTATAATTTTGCTTGCTATA TCTGGTGTTCACTCCCTGAGCAGGACTT TAATAATTCCATGCTGTTTAAGTTCTTGA GTCTTATACTTAAGCTCAGTTCTAAGGTT GTTTGTCTTGCAAAAGCTΠTGCCAAACA AAATCAAGGCTCAGTCTCTATCAAAGCCT ACCCATAGCAAAATATTTAATAACACATG ATAAAAGCTCACCCTAGGGAAGTGTTCTT GGCATTCCAAAGTCATAAATAAGAAACTA AGGGAAGCATTTCTAATATTTCCAGCTGT AGTGGACCTCCTTTTAGAGCATGTCCCC CCATATATTTTCAAACAAATAATAGGGTA ACAAATGCCCTCTTCTCTCCTCATTTCCA TTGAAGTAAACTCGAATGTTGATTATA TCCTGGGGTGAATGCCCACTTCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10882102 10 94456475 GGCATTGAGGCTGTGAATCTGCCCATCT C/G AGATGGCAAAATTTCTTAATTCTCTTGTT SEQ_0428 ccccTGGTTTTCTCCAGGTAACTCCACCT GGGTTAATGTTGTΠTGTTGTTATAAAATT

TGGGCAAGGTCTGCATTATATATATATCT TCTAAAATGAGAATGTTTTGCCTCCATTT

ATATTTACATGTATAAAAGTATATGTATAT CAGTTTAATTCCTTCTAGAGTATATTCATA

GTATTTTTAGAGGCAAGGTCTCGCTCTGT GAAAATGAATCATTGAGCCAAAGGGATG

CACCCAGGCTGGAGTACAGTGGCATAAT AATATTTGATAAATATTGTGAAATACTTCC

CATAGCTCACTGCAGCCTCCAACTCTTG TGGGAAAGTΠTGTCAATTTATATCAGTG

GGTGCAAGGGATCCTTCCACCTCAGGCC GAGAACAAGGATCATTTCTCCATATCTTC

CACAAGTAGCTGGGACTATAGGTGCATG ACCAATGGAAGTGCTG I I I I I CTAATCTT

CTACCACACTTGGCTAATTAAAAAAAAAA TCTTAATTATTTAGGAGAAGAATAGTATG

AATTTATAGAGGTAAGATCTCTATGTTGT CTGTATTTTAATTTTACATTTCATTCCTTT

CCAGGCTGGTCTCGAACTCCCGTCCTCA CATTATTCCCAAAGTTGAATTTTAAAAATA

AGCAATCCTCCTGCCTTGGCCTCCCAAA TGCTGGCCAGGTGCTGTGGCTCACGCCT

ATGCTTGGGATTACAAGCATGAGCTACC GAAATCCCAGCACTTTGGGAGGCCGAGG

CTTTGGGCACATAATGTATTATTAGGTA CGGGAGGATCACGAGGTCAGGAGATCC

AGACCATCCTGGCTAACACAGTGAAACC

CTATCTCTACTAAAAATACAAAAAATTAG

CCAGGTGTGGTGGCACGTGGCTGTAGTC

CCAACTACTTCGGAGGCTGAGGGAGGA

GAATCACTTGAACCCGGGAGGTGGAGGT _W

TGCAGTGAGCCAAGATCACGCCACTTCA &

CTCCAGCCTGGGCAACAGAACGAGATTC

TGTCTCAAAAATAAATTTAAAAAAATGCTA

ACCTTTTATTTC I I I I I CTATTTGAATTCTT

TTA l I I I I IATTA I I I I IATTA I I I I I I GAG

ACAGTTCAGTCTGTTGCCCAGACTGGAG

TGCAGTGGTGCCATCTCGGCTCACTGCA

ACCTCCACCTCCCGGGTTCAACTGATTC

TCCTGCCTCAGTCTCCCAAGTAGCTGGA

ACCACAGGTGTACACCCCCATGCCCGGC

TAA I I I I I I GTA I I I I I AGTAGAG ATG G G

GTTTCACCATTTTGGTCAGGCTGGTCTCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11187144 10 94459960 CACTTACTGGAGACTTATA1 I I I I I GCATT Crr ATGACAATTGTATATTTAACTTTTTGAGGA SEQ_0429

M i l l CAAATCTTTATGAATGTCTTCAGTA AATTCTAAACCATTTTCCATCATCACTGT

AAGTTAAATATTTTCTTTATTTAATACATA GCCATTTTACATTCCCACCAGCAATGTTT

CTCATTAAAAATTTTCAAGTTTATTGAGGT GAGGATTCCAGTTTCTCCGTCCTTACCAA

GAAATATAACATAAAATTAGCCATΠTAAA TACTTGTCCTTTTATAGAAAAATTATAGG

GTGAACAATTCAGTGGCATTTAGTACATT CAAGCTCATGGGTATGAAGTGGTATATC

CAAAATGTTGTGCAAACACCACCTTTATT ATTGTGGTTTTGATTTGCATTTCTCTAATG

TGTTCCAAAAGATTTTCTTTTCTTTTCCTT ACTAATGATGTTGGGCACCTTTTATATGC

I I I I I I I I I I I M I GATTTAGC I I I I GTTGC CTATTTGCATTTGTATACCTTCTTTGCTTT

TCAGGCTGGAGTGCAGTGGTGTGATCTT TTTA I I I I I IAI I I I ΪGAGTAGTCAAGTGC

GGCTCACTGCAACCTCCACCTGCTGGGT AGTAGTGAGAAGGGGGAAAGAGTAGAAC

TCAAGCGATTCTCCTGCCTTAGCCTCCT AAGGAGTTCGATCTATAACTGACTGAACA

GAATAGCTGGGATTACAGGCAAGTGCCA ATCAACTGAGATAACTCACTATGTTCAGA

CCACACCTGGCTAAGGTTTTGTA I I I I I G CCAGCCTGTATACCTTCTTTGGAGAAATG

GTAGAGATGGGGTTTCACCATGTTGGCC TCTTTTCAAATTCTTTACTCATTTAAAAAT

AGGATGGTCTCGAACTCCTGACCTCAGG TGTGTTGTTTGTC I I I I I I GTTGTTGAGTT

TGATCTACCTGCCTCGGCCTCCCAAAGT GTAGGAGTTTGTTACATATTCTGGATACT

TCAGGGATTACAGGCGGGAGCCACCATG AAACGATTATCAGATATATGATTTGCAAA

CCCGGCCTGTTCCAAAACATTATCATCTT TAI I I I I I I CCCATTCTGTAGGTTGTCTTT

TCCAAAATAAAACTCTGTATCCATTAAGC TCACTΠTTAAAAATTGATACACAACAATT

AGTCACTCCCCATTCTCTCTTCTCCCCAT GTACTTATTTAGAGGGTACACATGATATT

TTTCTGGCAACCACCAATCTGCTΠΓCTGG TTGATATGTGCATACAATGTGTAATGATC

ATGGGTTTACTTATTCTAAATATTTCACAC AAATCAGGGTAACTGGAACATCCATCAC

AAATGGAATAATACAATATGTGATCTTTC CTCAAACATTTATCATTTC I I I I I GTTGAG

GTGTCTTATTTATAAAACATTAGCATAAC AACATTCCACATCTTCTAGCTACTTTGAA

GTGTTTGAGGCTCATCCACCTTGTAGCAT ATATACAATAAATTATTGATAACCATTCTT

GTATCAGTACTTCATTCC I I I I I ATGGCT TCAC I 1 I I I ! GATAATGTCC I I I I I I GCAT

GGACAATATTTCATTGTATAAATAAAACA AGAAGTTTTTAATTTTGATGAAGTTCCATT

CAGTTTATTTATCCATTTGTTAGTTGATG TCTCAA I I I I I CTTTTGTTGCTCAAGCTTT

GACATTTGGGTTGTTTCCACCTTTTGGCA TGGTGTCATAGTTAAGAATCAATTGTCAA

ATTGTGAGTAGTGCTGCTATGAACATGTG ATCCAAGGTCATAAAGATTTAATCCTATG

TGTCCAAGTACTTATTTGAGTATCTATTTT ATCTCTTCAAAGAGATTTATTATTTTAGCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7087591 10 94463609 CTTTGTCTTCCTCTnTCATGACCTTATTT A/G AGACAGACCCGCTCTATTGCCTAGGCTG SEQ_0430

CTTCAGATGGATGTTTTGAGGTTATTTTC GAGTACAGTGGGGCAATCTCAGCTCACT TATTTTGAGAAAACTATACAAATCTGATTT GCAGCCTCTTTCTGCTGGGTTCCAGCAA ATTATCACAATAGCTCAAAAGTAGTTCCT TACTCCTGCCCCAGGCTGCCAAGTAGCT GTTGAAGTTCTCCACATTGTCAATACTGT GGGATTACAGGTGCCCACCACCTTGCCC GACCTCCTGTCAGTCTCCTACACTGGAT AGCTAA I I I I I GTC I I I I I AGTAGAGACA GGGAAACTCAAGCTGAGATTTCTCCAAA GCATTTCACTGTGTTGGCCAGGCTGGTC GTGCTTCCCACAGCGGCTGAACTAATTT TCAAACTTCTGACCTTAACCTGACCTTAA CAATTACCACCAGTGGTATACAGGCGTT GTGATCTGCCCGCCTTGGCCTCCCAAAG CCCTTTTCTCCACAGCCTCGCCAGCATC TACTGGGATCTTTGGGGTATCGATTTTCT TGATG I I I I I I GAC I I I I I AATAATAGCTG TCCTGTAAACCTTTGTGGCCGGTGGCAC TTCTGACTAGTGTGAGATGGTATCTCGCT CTTTGCCTGACTTCTTGTGTCCAGGAAGA GTGGTTTTGATTTGCATTTCTCTGATGAC ATGAGGTACACAGACAAGTGAAAGGTGA TAGTGATGTTGAGCA I I I I I I CATATATTT AGAAGTCAAAGGGGAGCTTTATTTAGTGT GTTGCCTGCTTGTGTGTCTTCTTTTGAGA TAGCACAGCTCAGAGGAGACCCACAGTG AGTGTCTGCTTATGTCTTTTGTCCACTTT GGTAGCTCCTCTCTGTAGGCAGGTTGTC TTAATGTGGTTATTTG I I I I I I GCCTGTTG CCATGGAGTGTTCAGCTCTCAGCAGAGA CATTATTTAAGTTTCTTATAATTTTGGATA CGAGGCCCTGGAGAGGGTAGCTCCTCT TTAGACCTTTGTCTGATGCAGTTTCTGAG CCACAGGCGGGTTGTTAAGAGCATCTCT TATTTTCTCTCCCATTCTGTAGGTTGTCT GCTCTCAGCAGAGAGGGTAGCTCTTCTC ATTTACTCTGTTGATAGTTTCTTTTGTGTG TGCAGCTAGTCTTGCCATTGTCTCTCCAT CACAGGCTCTTTAGTTTAATTAGGTTCCA CCTCTGCCCTCTTCTTGCTGATCCCAGG TTTGTCAA I I I I I G I I I I I GTTGCAATTGC GCTCAGAGGGGAGGAAGTATGTGTTGAT TTTTGAGGACTTAGTCATAAATTCTTTCC TGGTCCATGGGCAGCCATAGGTGACCTG

CAAGGCCAATGTTCAGAATGATGTΠTCG GAGGAGGCACAAGTCCCCACTCCAGTCT

AGATTTTCTTCTAGGA I I I I IATAATTTGA GCGGGACTGGCAGCCCAGCCCCCAGCC

GGTCTAACATTTAAATCTTTTAATCCATCT TTCAGGCCCTCTCTGGCCTGAAGGTGTG

CGAGTTAATTTTTATGTATGGTAAGAGGG GCCTTACTGGAACCTGCTCCCTTCCCTC

AAGGATCCAGTTTCGTTCTTCTGCATATG CAGGAATCTGTCTGCCTTCTGCTGCCATT

GATAGCCAGCTATCCCAGCACCAGTTAT CATGACCCCGGGGCTCAGCCCCAACCCT

TGAATAGGGGAGTCCTTTCCCCATTGCTT GCTTGGAGATTGGAGCAGGCACTGGGA

A I I I I I GTTGACTTTGCTGAAGATTAGAT GAGGAGAGGCCAGGCAATGGGAGCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10748582 10 94467199 CTTTGTAGTGGTGGAGTGTCTGGGGCGC AJT TAGGAATTCAGTTCCCTTGATTGCTTTGT SEQ_0431

AAGAGAGATTTCTGTCCTTCACCTGGCAA . ATAACAGCGCAATTCGCTGATGGACTAA

TAGTAGACCGCTAATTTATATCAGAGTGT AACAAAATTATGGTTTTGTATGTCTTATAG

GTTTCTTGCCCCTCCCCCAGGGGCAGAC GTTATCCA I I I I I I AATGTATTTATTTGAC

AGGCACTACCTTGTCCTCAGACAAGGCT ACATTGCGGGG I I I l I I I I I GTTTTGTTTT

CAAAGCATGAATGGGCTTCCCTAGGTAT TGAGACAGAGTCTCACTCACTCTGTTACC

GCCTGCTCCACCCTAAAACCTTGGCAGG CAGGCTGGTGCACAGTGGCACAATCTTG

TGCTGTAGGGCTGTACCACCAAGGGGGA GCTCACTGCAACCAACCTCTGCCTCCCG

AGGGTCTCCCAGGCCTACTGTGCTGTTT GGTTCAAGCGATTCTCCTTCCTCAGCCT

CCAGTCTTTCTCATGCATGCCGAGTAGA CCCGAGTAGCTGTGATTATAGGTGCCCG

GGCCAGTGGAAAAGGATGGCAAGCAGAT CCACTATGCCCAGATAA I I I I I GTA I I I I I

GGGGATTTCTCTGTGTCCAGCGTGCTCA AGTAGAGATGGGGTTTTGCCATGTTGGC

GGGCTTCTAAACTGCCATGCTAGCTTATC CATGCTGGTCTCGAGCTCCCTCCTGACC

CTTTGCCGGTAAGAATTTGTTTTCTTCTT TTAGGTGATCTGCCCGCTTTGGCCTCTC

ATCCAGTTTTCTGATGATTGTCTGTTCTT AAAGTGCTGGGATTACAGGCGTGAGCCA

CCCATTCTCTGCCAAAAGAGGAAACAGC CCGCGCCCGGCTGGTTATCCA I I I I I CT

TGGTGTGTCTTGTCCCI I I I IGGAAGGAC CTTGTGTATGCCAGCCTCACAGAGTGTG

TTGTGAGCC . GGATATGAGAAAGA

U)

90

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7923837 10 94471897 CACTCGATAAATGTTCATTGAGGCTGGG A/G TTTACCATTTTAAAACGTAAAAAAAAAGG SEQ_0432

CATGGTGGCTCACACTCCTAATCCCAGT AAATATTTGATTTGATTAATAGCTGAACT

ACTTACAGTGGCCAAGGTGGAAGGATCA GACAACGTGCAAGAACCATTTAATAATGA

CTTGAGGCCAGGAGTTTGAGACCAGCCT CCAATCATGAAAGGTTATGGAAAAAGAAA

GTGAAACATAGCAAGATCTCATCTCTGCA TGATTTAAGAAGGCCAAGAGCCAGGCCA

AAAAAAAA I I I I I I I I GAGACAGAGTCTC AGGTATTGGTAAGCCCTGAACTCATCAC

TCTGTGGCCAGGCTGGAGTGCAGTGGT ATGTCTGGAGTCGACAGTTCAATCAGTT

GCAATCTCAGCTCACCGCAACCTCTGCC

TCCCAGGTTCAAGTGATTCTCCTGCCTCA

GCCTCCCAAGTAGCTGAGACTACAAGCT

CGTGCCACCACGCCCGGCTAATTΠTCT

ATTTTTAGTAGAGACAGGGTTTCACCATG

TTGGCCAGGATGGTCTCGATCTCCTGAC

CTCGTGATCCACCCGCCTCAGCCTCTCA

AAGTGCTAGGCTTACAGGCATGAGCCAC

TGCACCCAGCCAAAACTTTTTTTAAAAAA

ATTAGCCAGGCGTGGTGGGGGGCACCA

GTAGTCTGAGCTACTCAGGAGGCTGAGG

TGGGAGGATCGCTTGAGTCCAGGAGGTT

GAGGCTGTAGTGAGCTATGATTGCACCA _W

CTGCACTCCAGCCTGGGCGACAGAGTGA £

GACCTGTCTCCAAAAAGAGTTAAAAAACT GTTCATTGAAATGTTTATAAAATAGGTGG TTCTCAATATCTCATATCCTATTTCCAGAA TTATGAAGAACAGTACAGTCAAGGGGGC AGGTCTTGCAGTAAGCCTGACGGGGTTT GAATCCTAGCTGTATGACCTTAGGAGAG TTGCAGAGCTTCTCTGAGTTTCAGATTCC TTCCGTTATAAAGCAAGGATAGGAATAGT ATCTACTGCAAAAGGTTGTTGCAGAAGTC CAATAAGAGAAGGCACACATAGTGCTTA GAATAGTGCCTGGTACATAGAAAATGCT rs7923866 10 94472056 AGATTTTTATAGCATAGGCMGAAACTTT C/T CTGAACTCATCACATGTCTGGAGTCGAC SEQ_0433

GTGGCACTGGTTGTTTACCATTTTAAAAC AGTTCAATCAGTTCTAGTTTTGAATATGG

GTAAAAAAAAAGGAAATATTTGATTTGAT GCAGGAGCTTTTTGTAAAAAAAAAGTTTT

TAATAGCTGAACTGACAACGTGCAAGAA GGGGCAATATGCATATGGCTTTCTTTTCT ccATTTAATAATGACCAATCATGAAAGGT TTCTTTCTCTΠTCCTGCCCCCTGGGCAA

TATGGAAAAAGAAATGATTTAAGAAGGCC TATGTGTACTGCTTTCTGAGAATGAGTTT

AAGAGCCAGGCCAAGGTATTGGTAAGC CCAAATAATTGTGTACCTACTGATGCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2497306 10 94475191 AAACTAAGACACTAAGGAAATCAAAGCAC G/T GGTTAAAAAGTGAAAATCCCAGTCAATTA SEQ 0434

ATCTGGAGGACTGTGAAGGAAGAAGAGA ACTGGCTATTTTGTTTACATAAAGGCAAC AAGATTTGATATCAGGTTAGGTATTCACA TCATCAC I I I I I I I I I CAACCAACAAACTG CCAGAGAAGGATAGTAACTAAAGGAAAA ACAGGTTAAACACACACACACACACACA TCTCACCTTGAATGTGTGCTTGTTTGACT CACACACACACACACACAAGCCTGAATT GTGTGACATTGTGAAAAGCAACTTAGCAA GAGCAGTTGTTTTGGCACCATTCTGAATT AAGTTCTCTTTGTCTTTGCAATGATGAC GCTCTGAACAGAAACTGAACATTATAA rs2488075 10 94480154 AGGAGAAGAGCAAAGGGAAATCTTTTTC A/G AGAAATTGGAAACTACAACTTTGTGCTTT SEQ_0435

AAATATTTTTCAATGTTTGCCACAATTTTG CGTATGAGAAATACAAAATGAGCAAAAAA CCACC CGGGGCTTAGGACAGGTAAGGGATAGG TACTGCCMGGCTTTGGATCTATGTCCAC ACATG I I I I ICTCCCACAGTCATCAAATG TCAAAGATTTAATTTATTTCGTGATTCTCC AGCCCTATATTCCCCACCCCCACCCCA rs2497304 10 94482696 AAGGCTGGTAGAGCCCCAGGTGGGGCC A/G TACTGCTCCAGGGTAGTCAGGAAACAGA SEQ_0436

ACCCCTTGGCAAATGGGGCACAAGCAGG GGGCAAGGAAAAAAGTAGAGGGGAGTG ATTTCAGCTCCAGCCAGCTCTTCAACCA TCAGAGAAGAAACCTCTAAATAGTGGAG GATGTCTTTGTGCAGTGCACAAATTGCAC GTGACTATTTTGAACCCTCAGCGTCAGCT AACTGTACACAGAAGACCTGTGTAGCTAT GCTCCATCTTACTTTGCTCATTGTAAACC

O CAGAGTAATTTTGAATTACACATCTTGTC TATGGTCTCAGTTGGAAAGCCAAGAGGA CCTTCCTTTGTCCAGTCAGAGATGAAAG TGTTTATATAGGGTGGATCCAACCACAAA CG CT rs 17732523 10 102151091 CACCACTGCACTCCAGCCTGGGTAACAG C/T CTTCACTCAATATTATACTTATATATTTAC SEQ_0437

AGCCAGACTCCGTCTCAAAAAAAAAAAAA CCACATTGATATATGTATCTCTAGTTATTC AAAAGAAAAAGAGGGATTCTCCTGCAGT ATCTGTTCTGTTCATGGACATTGAATTTA CTTGGGTTTTTTTTT TTTCTAGCTTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10883477 10 102151386 GCCAGTATTTTAACCTTTATACAAAGATA A/G CTTGATATTATCAGACCTACTTTCCAACC SEQ_0438

AGAGGGGCTGGGTGTGGTGGCTCACAC TACTTTTGTAGCTTTAATTCCTTTTCTGCA

CTGTAATCCCAGCACTTTGGGAAGCCAA TGAATCTTTGATTCCAGCCATATTGTAGT

GGCAGTTAGATCACCTGAGGTCAGGAGT ACTTGCTCCCCCTTGAACATTCTATAATT

TCCAGTCCAGCCTGGCTAACATGGTGAA GATTCCCCTACTCCCTCAAGTATTTATTG

AACCTGTCTCTACTAAAAATACAAAAATT AGTAGCTATACACGTCAGAAGCCCTGCT

AGCCAGGCGTGGTGGCGGGCGCCTGTA AAGTGCTAGGAAAACAAAGATGAAAG

GTCCTAGCTACTCAGGAAGCTGAGGCAA

GAGAATTGCTTGAACCTGGGAGGCGGAG

GTTTCAGTGAGCCGAGATCGCACCACTG

CACTCCAGCCTGGGTAACAGAGCCAGAC

TCCGTCTCAAAAAAAAAAAAAAAAAGAAA

AAGAGGGATTCTCCTGCAGTCTTGGGTT

I I I I I I I CCTTCACTCAATATTATACTTAT

ATATTTACCCACATTGATATATGTATCTCT

AGTTATTCATCTGTTCTGTTCATGGACAT

TGAATTTATTTCTAGC I H I I GCTATAAAT

ATTTTGTATCTGTCTCCTTTGTATACATGT

GCAAGAAACTCCCCAGAATTGAAATTTCT

GGGCCACAGGATATGAGCATTAGACTTT ^' w

ATTAGATACTGATAAATAGTTCTCCAAAA ^

TGGTTGTGCCAACTTAACAGTCTCATCAG

CAGTGTATGAGTTTCTACTCCTCCACTTC

TTTACCAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10883478 10 102152842 TTAAAACAAAACAATAAGCCAGGTGCACT C/T GTAACAGAAAGACTTTAAGAAAACAACTC SEQ 0439

GGCTCATACCTGTAATCCCAGCACTTGG TTTTAAAAGTCATCTATGCTATTCATCTG

GAGGCCGAGGCAGACGGATCACCTGAG GCACAAGAAAACATGTTATGTAACATTAT

TCAGGAGTTTGCGACCAACCTAGCCAAC AAAATCTAGTCAATAGGCCGGGCGTGTT

ATGGTGAAACCCCGTCTCTACTAAAAACA GGCTCATGCTTGTAATCCCAGCACTTTG

CAAAAATTGGCTGGGCGTTGTGGTGTGC GGAAGCCAAGGCGGGCATATTACTTAAG

GCCTGTAATCCCAGCTACTCAGGAAGCT GTCAGGAGTTCAAGATCAGCCTGGCCAA

GAGGCGGGAGAATCACTTGAACTCATGA CATAGAGAAACCCCGTCTCTAATAAAAAT

GGCAGAAGTTGCAGTGAGCCTAGGTCAT ACAAAAATTAGCTGGACGTGATGGCATG

GCCACTGCACTCCAGCCTGGGCAACAGA CACCTGTAGTCCAAGCTACGGGGGAGG

GTGAGACTCCATCTCAAAAAATAAAAATA CTAAGGCAGGAGAATCGCTTGAACCCAG

GAAACAATATCTCCCATACAGCTTAGAAT GAGGCAGAGGTTTGCAGTGAGCCCAGAT

ACTGATGACACACAGTGTGTATTCATTCA CGCGCCACTGCATTCCAGCCTGGGCCAC

GTAATTACTTGTAGAATGAAAGATGAAAA AGAGTGAGACTCCATCACACACACACAA

CAAACAAGGGAGGGCTACATCATTGGTT ATACAAATACAAATACACACACACACACA

CCCATTCTCCCAGATGCTTGACCCTTCAA CAATTTAGTCAATCTTGAGGGCTTGCTCT

ACATTTTAAGCAATTGCTAATTTGGGCTG AGTATTTCTGTTTCCTGCTTCTTTAACAG

CTATTTACTATTGCCAA ACTCTACATTCCCATTTT rs 10883479 10 102152850 ACAATAAGCCAGGTGCACTGGCTCATAC A/G AAGACTTTAAGAAAACAACTCTTTTAAAA SEQJD440

CTGTAATCCCAGCACTTGGGAGGCCGAG GTCATCTATGCTATTCATCTGGCACAAGA K* GCAGACGGATCACCTGAGTCAGGAGTTT AAACATGTTATGTAACATTATAAAATCTAG GCGACCAACCTAGCCAACATGGTGAAAC TCAATAGGCCGGGCGTGTTGGCTCATGC CCCGTCTCTACTAAAAACACAAAAATTGG TTGTAATCCCAGCACTTTGGGAAGCCAA CTGGGCGTTGTGGTGTGCGCCTGTAATC GGCGGGCATATTACTTAAGGTCAGGAGT CCAGCTACTCAGGAAGCTGAGGCGGGA TCAAGATCAGCCTGGCCAACATAGAGAA GAATCACTTGAACTCATGAGGCAGAAGT ACCCCGTCTCTAATAAAAATACAAAAATT TGCAGTGAGCCTAGGTCATGCCACTGCA AGCTGGACGTGATGGCATGCACCTGTAG CTCCAGCCTGGGCAACAGAGTGAGACTC TCCAAGCTACGGGGGAGGCTAAGGCAG CATCTCAAAAAATAAAAATAGAAACAATA GAGAATCGCTTGAACCCAGGAGGCAGAG TCTCCCATACAGCTTAGAATACTGATGAC GTTTGCAGTGAGCCCAGATCGCGCCACT ACACAGTGTGTATTCATTCAGTAATTACT GCATTCCAGCCTGGGCCACAGAGTGAGA TGTAGAATGAAAGATGAAAACAAACAAG CTCCATCACACACACACAAATACAAATAC GGAGGGCTACATCATTGGTTCCCATTCT AAATACACACACACACACACAATTTAGTC CCCAGATGCTTGACCCTTCAAACATTTTA AATCTTGAGGGCTTGCTCTAGTATTTCTG AGCAATTGCTAATTTGGGCTGCTATTTAC TTTCCTGCTTCTTTAACAGACTCTACATT TATTGCCAACGTAACAG CCCATTTTAAAAGATC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10786590 10 102154594 GTTGGATTCTGCTCCAGGCCTGAAGGAA Cn TCTTTGTTGCCACCTGGTCACACCAGTG SEQ_0441

ACAGGG I I I I I l I CATAGACTTTTATACAT ACCTAAACAATATCTCATCTGTGGAAGCT ATCTACTTAATGACATTATCTATATCAGAA GGGTTTGGACTAAAAATCTAACAGGTGTA AACTATGTAAAGTTAGGTGAAAATATTTT CCTGAGAAGCCCTCACAAAGAGGTGCAA CTTTC I I I I I I I I I I I GTGACGGAGTCTC TAGCAAATAGTGATCTCTCATTAAGGAAA GCTCTGTTGCCCAGACTGGAGTGCAGTG AAAGAGACAAGCATTTGCGTATCCTAGTA GCGTGATCTCGGCTCACTGCAATCTCTG ACAATCATTTGATTTCCTTCAGGAGAGA CCACCCAGGTTCAAGTGATTCTCCTGCC TCAGCCTCCAGAGTATCTGAGATTATAGA CATGCACCACCATGCCTGGCTAA I I I l I I TGTATTTTTAGTGGAGACAGGGTTTTGCC ACATTGGCCAGGCTAGTCTCAAACTCCT AACCTCAAGTGATTCACCCACCTTGGCC TCCCAAAGTGCCAGGATTACAGGCGTGA GCCACCATGCCCGGCCAATCCCTTGTGT TTAAAGCTAGCCTGCAACCTTCCCAGATT TAAAGTCGGCAAAGAGACCAGACACCAA GGACATCCCTTAGA rs1 1 190513 10 102155228 ATTAAGGAAAAAAGAGACAAGCATTTGC A/G AAAGCTC I I I I I GCAAGGATTTAATTACC SEQ_0442

GTATCCTAGTAACAATCATTTGATTTCCTT ACAAGGATCAGGAGGAAATGCACAGGAA 4- CAGGAGAGAAATTCCATTTTCATCTAGCC TTTACTCATTTTACTCTCAGGTTGAGGAC TTGGGATTCAGATGAAGGATTCTAGGGG CACTATACACTATCTATGAATGTGTTTAC AAAAAAGATTCTCTTAATGAATACTCTGC AAACTTCAAGATGAGGATGATACCTTCCT AATAATAACTGCAATTATTTATTTATTTATT CAGTTACTGGAATTCTATGAAGAAAGCGA TTTGAGACAGAGTCTCGCTCTGTCGCCC ACCAATTCATGGACACTTTATTCAATG AGGCTGGAGTGGAGTGGAGTGATCTCAG CTTACTGCAACCTCTGCCTTTCGGATTGA AGCAATTCTCCTGCTTCAGCTTCGTGAGT AGCTGGGATTGCAGGTGCCCGCCACCA CACCTGGCTAA I I I I I GTAI I I I I AGTAG AGACGGGGTTTCACCATGTTGGCCAGGC TGGTCTTGAACTCCCAGCCTCAAGTGATT AGCCCACCTCAGCCTCCCAAAGTGCTGG GATTACAGATGTGAGCCACTGCACCCGG CCACAACTGCAATTTAAAAAATTTTCCTTA AACATTTCACAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID r$3829162 10 102162742 CTTTCCAACCTTTTGTATTCATCCAAACA G/T TTAAACCCAGATGAAGATAAGGTATCAAA SEQ_0443

AAGCTAATGCACTTTTAAAAATCCTATAC ATAAACCTCAGGCAGACTGAGCTGTGCC TTG I I I I I I I I CAGACCATCTCGCTCTGT ACAATTTTAACACTAACTGATGAAGGCAG CGCCCAGGCTGGAGTGCAGTGGTGCAA GATGCTTCTCCTGCTCAGCTGAGCATCC CCTCGGCTTACTGCAACCTCCGCCTCCT TGTCTCCCAAACTCAAAAAACTAAAATCC GGGTTCAAGTGACTCTCATGCCTCAGCC TGGAATCTTAGAACTGGAAGTGACCCTT TCCTGAGTAGCTGGGATTACAGGCACCT GTCTTTGTGACTGTCCTTGAGCTCTGCTA GCCACCATGCCAGGTTTGTTTGTA I I I I I AGTAGAGACAGGGTTTCACTATGTTGGC CAGGCTGGTCTCAAACTCCTGACCTCAA GTGATCCGCCCGCCTCAACCTCTCAAAG TGTTGGGATTACAGACATGAGCCACTGC GTCCGGCCTAAAAATCCTATATTTGCAAT CTATGTGACCACAACTGA rs3750723 10 102162979 TCAGGCAGACTGAGCTGTGCCACAATTT CfT GAAGTAGGACTCTGCGCAGCCAGAATTT SEQ_0444

TAACACTAACTGATGAAGGCAGGATGCT TTTGTGTTACCTCTTTGTAATCAGATAGG TCTCCTGCTCAGCTGAGCATCCTGTCTC GCACAACTGGCTGAGATTGTTGTCAGTA CCAAACTCAAAAAACTAAAATCCTGGAAT TGTGGGTGTGGCTGGAAAAAAATACCCT CTTAGAACTGGAAGTGACCCTTGTCTTTG CTGTGACCAATAGTTCTTTCTTCACTGTA TGACTGTCCTTGAGCTCTGCTACCCATG CACAGCTTTCATACTGTTTCTCATGAATA AGTTTTGCCTCCAAAATTGTCCCTTTTAT AAACATATTCACATGACATTTTGTACTTT 4- A rs10883483 10 102164234 GAGAGAACCCATCTCTAAATACATAAAAC C/T AGGAGAAAAAGAAAGAAGGGAGGAAAG SEQ_0445

I I I I I I I I I I I I I I I GAGATAGAGTCTTGC GAGAGACAGAATCAGATTAGTTTCAATTC TTTTGTTGCCCAGGATGGAGTGCAGTGG AGACTTTTCACAAAAATACAAATTTTGGC CGTGATCTCGGCTCACTGCAACCTCTGC CAAATTTTGAAAATATCAAGCATCTGCCG CTCCCAGGTTCAAGCGATTCTCCTGTCT AGCGTGGTGGCTCATACCTGTAATCCCA CAGCCTCTCGAGTACCTGGGACTACAGG GCCCTTTGGGAGGCAGAGGCGGGCTGA CACACGCCACCACGCCCAGCTA I I I I I I I TCACCTGAGGTCAGGAGTTCAAGACCAG A I I I I IAGTAGAGATGAGGTTTCACCACA CCTGGGCAACATGGTGAAACCCCATCTC TTGGCCAGGATGGTCTCAATCTCTTGATC TACTAAAAATACAAAAATTAGCTGGGCTG TCATGATCCTCCTGCCTCGGCCTCCCAA TGGTGGCACGCACCTGTAATCCCAGCTA ACTGCTGGGATTATAGGTGTGAGCCACC TTCAGGAGGCTGAGGCAGGGGAATCGC GCACCCAGCCCATAAMCATTTTTTAAAA TTGAACTCAGGAGGCAAAGGTTGCAGTG ACAAAAGCAAGAAAGAAAAAAGCAAAAG AGCCGAGATCACATCACTGCACTCCAGC TCCTGGACTCTGGGTCTATAAACTAATTT CTGGGTGACTCAAGGAGAGCCTGTCTCA GCTTTCTTCCTAAAAAGTCTGTTTACGTT AAAAAAAAAAAAAAAAAAAGACATGAAAA CCAAGACAGAAGAAATTCCCAATAGCTTT CATGAAGCATCAGTAAATTGAACATGATA C I I I I I GTGGAGCAAATAAATGGAAGATG CCTTCG I I I I I GTAGACCAAAGTGAATCA GAAGGAGGGAAGA CTTGGTAGATCACGCAGCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4919458 10 102167718 GAATTAATGTTAATTCAACATTAGAAAAC A/G ATAAAAAAAAAATTGTAGGGTGAAATCTG SEQ_0446

ACTTCTTTTAAATCTGAAAAACAATAAGG TTACTATCTTGTCTCTACTATCTTTGCCTG GTTCTTATACTACG I I I I I G I I I I I I GTTT GCTAGTTTCTGCCTTTTGTTTAAAAATTAT TGAGATGGAGTTTCACTCTTGTTGCCCA AGGTAGGATGGGTGCCGTGACTCACACC GGCTGGAGTGCAATGGCGCAATCTCGG TATAATCCTGGCACTTTGGGAGGCTGAG CTTACTGCAACCTACACCTCCCGGGTTC GTGGGCAGATCACTTGAGCCCATGAGTT AAGTAATTCTCCTGCCTCAGCCTCCCGA CAAGACCAGCCTGGGCAACATGGCGAAA GTAGCTGGGATTATAGGCATGTACCACC CCCCGTCTCTACAAAAAAATACAAAAATT ATGCTCAGCTAATTTTGTATA I I l I 1 IAGT AGCTGGATGTGGTGGCACATGCCTGTAG AGAGACGGGGTTTCTCCATGTTGGTCAA TCCCAGCTACTTGGGAGGCTGAGGTGAT GCTGGTCTCGAACTCTTAACCTCAGGTG AGGATGGTTTGAGCCCAGGTGGCAGAG ATCTGCCTGCCTTGGCCTCCCAAAGTGC GTTGCAGTGAGCCAAGATCATGCCACTG TGGGATTACAGGCTTGAGCCACCACAGC CACTCCAGCCTGGGCAACTCTCAAAAAA CGGCACTACGTTTTAATTATTATTATTTTT ATGAAAGAAAGGAAAGAAAAGGAAAAAA TCTCTTTGGTAAAATAAGCTCATACTATG AGAAAGAGAGAGAGAGATAAAGAGAGAG ATATCCACTTAATGTGGAAAAACTAAGAA AGAGAAAGAAAGAAAAAGAAAGAAAAAG AGGGATTTCTCTAGTTCATATGGCAAATG AAAGAAAGAAAGAAAGAAAGAAGGAAGG ACCAGCTGAGCTAG AAGGAAGGAAGGAAGGAAG rs10509743 10 102180396 TGTTCATGAGACTACTTATTAAAGCACGA C/T TCAATTAACCAGTATACTCTGTTCCAAGA SEQ_0447

AAATGGACTGAGGCAATTTAGAGAGATTT TTTTACAG I I I I IAGACTTA I I I I I CTTTA 'Jl CAAACAAAAAGTGTCTCTCATTAACCCAT CAACCATGACAATATTGCTTCTAAATCCC ACTTAATCAGAAG AGCCATTTCATA rs 12360395 10 102184064 GTCATTTTAGGGCCAGTTTAGGGTAGGA AfT CTCTGATTCATAAATTTTGAGAGGAGCGC SEQ_0448

AAGAGGGTGACAGCAAGAATTAGAAGGT AGTCATCTGTCTTTTTAAAAAGCTTTTTCA GTAGGGGAGGGCGCCAGGGAAGTAGGG GAAGATCATCAGTGTGTTGTTTATCTAAG AAAGGAGATGTTAGGAAGAAAGCTGGTG ATTTAGAAGCGAAAAAATATTTTAAGGGG GGCTACTTCTGCCAGATAGGGCTTCCCT AAACCAGTCCTAGTCCTCTCAGGACTCT AGCACCCCAAATCTGATCCATTGCAATTA GTGAATACAACTTC I I I I I I I I I I I I I I I I I GGAAAGTTATCTCCTAGTCCAAGGAATTT I I I I I I I GAGACAGAGTCTCATTCTGTCG ATCCAGTAGTTCCCAAATCTGGCTGACT CCCAGGCTGGAGTGCAGTGGCTCCATTT GGCAGAATCACCAGGAGAACATTTTTAAA CTGGTCACCGCAAACTCTGCCTCCTGGG GATACAGATTCCCAGATTTTATCCCAAGA TTCAAGCGATTCTCCTGCTTCAGCCTCCT A GAGTAGCTGGGATTACAGGCGCCCACCA CGATGCCCAGCTAA I I I I I I I GTATTTTTA GTAGAGACGGGTTTCATCATGTTGGCCA GGCTGGTCTCGAACTCCTGACCTCAAGT GATCCACCCACCTTGGCCTCCCAAAGTG CTGGGATTACAGGCATGAGCCACTGTGC CCAGCCAGCCAGAATTTTCTTAAAGCAAA GCAGCCTAGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs872290 10 102188869 TCAGAACACTCAGGGATATAATAATGTGT A/G AGGATAAGAATTGTGTACTGTTGACTGTT SEQ_0449

CAAAGTGTATGTAAAGCAGGAAGAGTCA GTCTCTCCAGAGCCTAACAGTTCCTAAG

GCAGCTATAAATACTCTCTCACAGTAGCA CACGTAACAGGTGCTCAATAACTATTCAT

ATCAGGAGAAACTAATAAAGAGAACGAA AGAATGTAATGAGATCTTCTGGTACCTCA

GAAGAAAATAGCGATTGGCACCCCACCA GCTCCTTACTTTTACATTTGCTGTGCTTT

TGCCAGTCTTCCCAGCTTCATCCCCAGA CAGCATAGCTTTTCTGGAGTGTGCTATAA

TCTCTTTACCTGCCTCACCGCCGCAATCT TTCAGGAAAAGAAAATATCCTTCCTTTCT

CCATCTTCACCCCCTAACTGCACCCCTC GAAA I I I I I I I I I I I I AA I I I I I I I GTAGAG

CCTTCCTCTGTGCTCTCACTGTACAGCCA ATGAGGTCTTACTATGTTTCCCAGGCTG

ATTGCCTGTTTACTCCATGGAATCACCTT GTCTGAAACTCCTGGGCTCAAGCGATCA

AGTGATCCTCCCACCTCAAGAGTGCTGG

GATTCCAGGCCTAAGCCACCATGCCCAG

CCAAAAACATCCTTTCTCATCTCTTGCTT

TGTCGCCCGGCTGGAGTACAGTGTTGCG

ATCTCGGGTCACTGCAACCTCTGCCTCC

AAGTTCAAGCAATTCTTCTGTCTCAGCCT

CCTGAGAAGCTGAGATACAGGCACACAC

CACCATGCCCAGCTMTTTTTGGATTTTT

AGTAGAAAAGGGTT

W

4-

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190540 10 102192619 CTGAGGCAAGAGCATCACTTGAGCCAGG C/T GTGACCACATCTGAGGTAGGCCTGTAGT SEQ_0450

AGGTGGAGGTTGCAGTAAGCTGAGATCA CAGTCCCTATTCATTATAATTTCATAGCAT

CACCACTGCACTCCAGCCTAGGCGACAG ATATTATCTGAAGTTATTTTGCCATTTGTT

AGCGAGACTCCATCTAAAAGAAAAACCA CATTATTTCCCTCTCCCAACCACCACCTT

AACAAACAACAACAACAAAAAAACCCATT CAAGACAACAATAATTAGTTTCTTTCTTCT

TTGGAAAAGTTTGGCAGCTTCTTAAAATG TCACAGCTGTATCCTCAGTGCATACAGC

TTAAGCATACACCTACTATAAACCCAGCC AGTGTCTAGCACACCACAGACACTCACA

ATTCCATTTCTAAGTATTTATCCCAMTAA TGTTTGTTGAATGAATGAATGGGTGACCT

ATGAAGACATAGATCCATTAAACACTTGT TCAAGCAGTCTGGAAAGAGAGCAGCCAG

ACTAAATGTTCACAGCAGTTTTATTTATTT TTCTCTACTTAAATGTTTTCAGAAAAGATT

TCATTA I I I I I AAA I I I I IAAAATAGAGAT CCACCATTTTTCTGACAATAAAAATGAAG

GGGGGGTCTCACTATAATCCCTGCTCTT TCCAGTGTCCAATAATATTTAGTTGTCAG

TGGGAGGCCAAGGTGGGGAGATAAGCT AATGGTTCTCCTAATATCCAACCTAATCC

GATGTCAGGAGTTCGAGACCAGCCTGGC TTCCCAAAGCAATTTCTGTCCTGTCTCTT

CAATATAGTGAAACCCTGTCTCTACTAAA CTCATTTGTCTGGTGCTCAATGGAATAAT

AATACAAAAATTAGCTGGGCATGGTGGC TAAATTAGCTTACCATGGTCAATAATAAA

GCATGCCTGTAATCCCAGCTGTTCTGGA TGTACCAGGCCTTCTCAACAATAATTCTA

GGCTGGTGTAGGAGAATCACTTGAACCC CTTCTCATCATATCTCACATTGCTGTTCT

AGGAGGAGGAGGTTACAGTGAGCCGAG CTCTGGTCC

ATTGTGCCATTGCACTCCAGCCTGGATG £

AGAGTGAGACTCCATCTCAAAAAATAAAA -¹

TAAAATGAAATAAAATTTTAGAAAACGCA

ATGAAATCTTTCCCCTGGACTACCACACT

AGCTTCCTAAATGGTTCTCTCTGCTTTTC

I I I I I I I I I GAAATGGAGTCTCACTCTGT

CACCGCGGCTGGAGTGCAGTAGTGAGG

CCTTGGCTCACTGCAACCTCTGCCTGCT

GGGTTCAGGTGATTCTCCTGCCTCAGCC

TCCCGAGCAGCTGGGATTACAGGCACGC

ACCACCACACCTGGCTAA I I I I I GTATTT

ATATTACAGACAGGGTTTCACCATGTCG

GCCAGGCTGGTCTTGAACTCCTGACCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190541 10 102193061 AGCTGGGCATGGTGGCGCATGCCTGTAA A/G GCTTACCATGGTCAATAATAAATGTACCA SEQ_0451

TCCCAGCTGTTCTGGAGGCTGGTGTAGG GGCCTTCTCAACAATAATTCTACTTCTCA

AGAATCACTTGAACCCAGGAGGAGGAGG TCATATCTCACATTGCTGTTCTCTCTGGT

TTACAGTGAGCCGAGATTGTGCCATTGC CCTTGTCAAAAGTTCTCGGTCTCAAGTTT

ACTCCAGCCTGGATGAGAGTGAGACTCC CATCTGTGAAGCCCAGTATTCAACCCAAA

ATCTCAAAAAATAAAATAAAATGAAATAAA TATTACTGCTTGAAATAGCCTACATAAGA

ATTTTAGAAAACGCAATGAAATCTTTCCC AAAACTCAACGTATAAGTACCTACTT

CTGGACTACCACACTAGCTTCCTAAATG

GTTCTCTCTGCTTTTC I I I I I I I I I GAAAT

GGAGTCTCACTCTGTCACCGCGGCTGGA

GTGCAGTAGTGAGGCCTTGGCTCACTGC

AACCTCTGCCTGCTGGGTTCAGGTGATT

CTCCTGCCTCAGCCTCCCGAGCAGCTGG

GATTACAGGCACGCACCACCACACCTGG

CTAA I I I I I GTATTTATATTACAGACAGG

GTTTCACCATGTCGGCCAGGCTGGTCTT

GAACTCCTGACCTCAAGTGATCCACCGG

CCTTGGCCTCCCAAAGTGCTGGGATTAC

AGGTGTGAGACACCGTGCCCAGCCTCTC

TGTTTCTTTTCTATCACTCCTCTAATCCAC W

TCTTCACGCAGCATCCAGGATA I I I I I I I ∞

CTAAAATATAAAGCATATCATGATGTGAT

GCTCTTCTGCTTAAAACCCTCCTATGGCT

TCCAATTGCTCTTAGAATACAATCCAAAT

ATATGGTAGAGGCCAGGAGCGGTGGCT

CATGTCTGTAATCCCAGCACTTTGGGAG

GCCGAGGCAGGCAGATCATCTGAGGTCA

GGAGTTCGAGACCAGCCTGGCCAACATG

GCGAAACCCCGTCTCTACTAAAAAAAAAT

ACAGGCCAGGTATAGCGGGTCATGCCTG

TAATCCCAGCACTTTGGGAGGCTGAGGT

GGGCAGATCATGAGGTCAGGAGATCGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10883492 10 102196079 AGACTGCACTAGCCAAAGTTATGATGATA A/G AAATTTGATAGCTTAACACACTGAAACAC SEQ_0452

CCTCAGTTTTGTTAAACAGTATAGCACTA ATTTATGATCTCACACAGTTTATATGGGT

TTGTTAGAATAAGCACTGGAGTCAGGCA GAGAAATTCGGGCAGCTTAGCTGAGTGC

CACCTAGGTTCAAATCCTACTTCTGCCAC TTCCAGTTTAGTATTTCCCATGATGTTGC

TTACCTACTGTGTAAATCTGGGCACCTTA AGTCCAGAACATTGGCCAGTACTGCAGT

CCTTGCTTCTCTAAACCTTGGTTGCTTCA CATCTGAAGGTTTGACTGGGGCTGGAGG

CTCATAAATGAGGGCAATGATATTGCATC ATCCTCTTTCTAGGTGGCTGACTCACAGA

CCTCATAGAGTCGTGAGATTAAATGACTT GCTGGCAAATTGATGTTGGTTGCCAGCA

CATTCATGTAAACCCC I I I I I AGGGTTGT GGAGGCCTCCTTGCTGCAGTGACCCTTC

AGGAATTGCTCAATACATTTATTTGAGTT CATAGAGCTGCTTGAGTGTCCTTCCAAC

ACTACTATGAATTCC I I I I I I I I I I I I I I I I ACAGCAGCTGGCTTTCCCCCAGAGCAGG

I M I I I I GAGATGGAGTTTCACTCTTGTT CAGACCGAGAGAGCAAGATGGAAACAAT

GCCCAGGCTGGAGTGCAATGGCGCGAT ATCTTTTATAGTCTAGCCTCAGAAGTCAC

CTCGGCTCACTGCAACCTCCACCTCCCG ACGTGACCATTTCTGCAATATCCTATTAC

GGTTCAAGCAATTCTCCTGCCTCAGCCT ACAGGTCAGCCCTCTTCAGATATGGGAT

CCCAAGTATCTGGGATTACAGGCATGCA GTGAATATCATTAGGCAAAGATCATTTGG

CCACCACACCCACCTAATTTTGCA I I I I I AGCCATATAGAGACTGGCTATCACAATTT

TTAGCAGAGATGGGGTATATTATAAACAA CATGTCATATATCTTCTTTCATGGTGAAA

CTATAAGCCAATGTATATGAAAACTTTCA CACTGAAATTATTCCATTTCATTAACAAG

TCAAATGAACCATCTTCCAGGAAAAAATA ACAAAAGTTGCCACTATCATTTCTATTCT W

CAATTTACCAAGACTGACTCAAGAAGAAA ATTGAACTAGAGGTCTTAGTTGACACAGT ^VO

GAAAAACCCTTAATAATCCTATAACAAGG AAAATTGAACAAGAAATAAAAGGAAGAAA

CATTAAAGCAATAGCTAAAAATCAAGTCC CAGTCACTATTTTCAGATCACATATGTCA

AGGTGGTTTCACCAGTGAGTTCTCACATA ATATAAAAAAATGCAAAAGAATATCCCAC

CATTCAAGGGCCAAATGATTCCAACTTGT AAAGTGTTAGAATTAAAGTGAGTAATGTT

GCAAATCAATTCAGAGTACAGAAAAGGAT TCTGAATACAAAGTGAATATTAAAAAATA

AAATCACTCCCAATTAATTTTGTGAAACT AATTGTGCCAGCAACAATTGGAAAGTACA

GGCAGAATTCTTATAAAACTTGACAAAAA ATTTCAGGACCAGGCTCATCACCCTCCC

CTTTATGAATAAGGAAAATTATAGGTCAT ACCTTCTGGAGTCTTCAGTGTCTATTATT

AGTCACTCAGTAATATAGATGCAAAATCC CCACTCTGTGTGTCTATGTGCACTCATTG

TAATAAAGTGTTAGAAAACTAAATTTAATA TTAGCTCTCATGAATAAGTGAAAACATAC

ATGTTCAAAACTGACAATACTTTATGACC TGTTTTCTGCTTTCTGCTTCTGAGTCATTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190552 10 102196597 TTGCTTCTCTAAACCTTGGTTGCTTCACT A/G AAATTATTCCATTTCATTAACAAGACAAAA SEQ_0453

CATAAATGAGGGCAATGATATTGCATCCC GTTGCCACTATCATTTCTATTCTATTGAA

TCATAGAGTCGTGAGATTAAATGACTTCA CTAGAGGTCTTAGTTGACACAGTAAAATT

TTCATGTAAACCCC I I I I I AGGGTTGTΛG GAACAAGAAATAAAAGGAAGAAACAGTC

GAATTGCTCAATACATTTATTTGAGTTACT ACTATTTTCAGATCACATATGTCAATATAA

ACTATGAATTCC I I I I I I I I I I I I I I I I I I I AAAAATGCAAAAGAATATCCCACAAAGTG

TTTTGAGATGGAGTTTCACTCTTGTTGCC TTAGAATTAAAGTGAGTAATGTTTCTGAA

CAGGCTGGAGTGCAATGGCGCGATCTC TACAAAGTGAATATTAAAAAATAAATTGT

GGCTCACTGCAACCTCCACCTCCCGGGT GCCAGCAACAATTGGAAAGTACAATTTCA

TCAAGCAATTCTCCTGCCTCAGCCTCCC GGACCAGGCTCATCACCCTCCCACCTTC

AAGTATCTGGGATTACAGGCATGCACCA TGGAGTCTTCAGTGTCTATTATTCCACTC

CCACACCCACCTAATTTTGCAI I I I I I I A TGTGTGTCTATGTGCACTCATTGTTAGCT

GCAGAGATGGGGTATATTATAAACAACTA CTCATGAATAAGTGAAAACATACTGTΠT

TAAGCCAATGTATATGAAAACTTTCATCA CTGCTTTCTGCTTCTGAGTCATTTCAATA

AATGAACCATCTTCCAGGAAAAAATACAA AGGATAATGGCCTCCAAAACATCGTATTT

TTTACCAAGACTGACTCAAGAAGAAAGAA AACGATGAAATATTAGAAGCATTTCCACC

AAACCCTTAATAATCCTATAACAAGGCAT AAAATAGGATAAGATCAGGAGGCCCATT

TAAAGCAATAGCTAAAAATCAAGTCCAGG ACCGTCACCAATATTACATTCAAGTTTAG

TGGTTTCACCAGTGAGTTCTCACATACAT TCAATGCAACAAAAGAAGAAAAAGAATAG

TCAAGGGCCAAATGATTCCAACTTGTGC AGAAATATAAATATTGAAAAGGAAAGGCA _W

AAATCAATTCAGAGTACAGAAAAGGATAA ATTTGGTAATATCTATTAACACTTTAAGTA g

ATCACTCCCAATTAATTTTGTGAAACTGG TATATATTCACAAGTTTTAGGTG

CAGAATTCTTATAAAACTTGACAAAAACT

TTATGAATAAGGAAAATTATAGGTCATAG

TCACTCAGTAATATAGATGCAAAATCCTA

ATAAAGTGTTAGAAAACTAAATTTAATAAT

GTTCAAAACTGACAATACTTTATGACCAA

GTTGGGTTTATCTTAGGAATGCAAGCTTG

GTTTAGCATTGGAAAATCCACCAACATAA

TTCAAAATATTTGCATATTAATGAAAGATA

ATATGTTTATTCACTACATGGATACAATG

TATATGAAAAAATCCACCATCAATTCATTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10883493 10 102198178 TCTGAATGTGAGTAAAAGGTTTGCTGCA A/T TATGTCCTATATGTTATGGATTGAGTTGT SEQ_0454

GGGTTTGGGGGTGTATTTTGGTTGTTGTT GTCCTCCTAAAAGATATATTGCAGCCCTA

ATTGTTGTTGTTTTGAGATAGGGTCTCAC AGCTCCAGTACCTCAGCATGTGACTTTAT

CCTGTCTCCCAGGCTGCAGTACAGTGGT TTGGAAATAGAGTTGTTGTGGCAGATGTA

ATAATCTTGGCTCACTGCAGCCTTGACTT ATTAGTCAATTTAACATGAGGTCATGCTG

CCCAGGCTCCAGTGAACCTCCCACCTCA GAGTAGTGTGGGCTCTTAATCCAACACA

GCCTCCCAAGTAGTTGGGACTACATGCG AATGGTGTCCTTCTAAGAAGAAAAGAGG

CGAGTCACCATGCCAGACTAACTTTTGTA CCGGGGCAGTGGCTCACACCTGTAATCC

I I I I I GGTAGACAGAGAGTTTTGCCATAT CAATACTTTGGGAGGCCAAGATGGGAGG

TGATTAGGCTGGTCTCAAACTCCTGAGC ATCGCTTGAGGCCAGGAGTTTGAGACCA

TCAAGTTTTCCACCCGCCTTGGCCTCCC ACCTGGGCAACATAGTGAGACCTTGTCT

AGTGCTGGGATTACAGGTGTAAGCCACT CTAAAAACATATAAGAATTAGCCAGGTGT

ATGACCGGCCCGTTGGAG I I I I IAGAGT GGTGGCGTGCACCTGTAGTCCTAGCTAC

GAAATATTTAAAGGT TCAGGAGGCTGTGGCAGGAGGATCACTT

GTTCCCAGGAGTTCAGGGCTGCAGTGAG

CCATGACTGCACCACTGCACTCCAGCCT

AGGGGACAAGCGAGACTCTGTCTCTAAA

AATAAATAAATAAAAATTTTAAAAATGAAG

AAGAAGAAGAAGGAAGAGAAGAAGAAGG

AGAAGAAAGAAGAAGAAGGAGGAGGAG _W

GAGGAGAGAAAGAAGGAGGGAACACCG ^L

TGTGATGACAGAGGCTGAGAATAGAGTG ATGTGTCCACAAGCCAAGAAATGCCAAG GATCGCCAGCAACACCAGAAGCAAAGAG TAAGGCTTGGAACAGATTCTTTCTCTGAG CCCCCAAAGAGGAACCAATCCTGCTGAC ACCTTAATTTTAAACTTCTGCTCTCTAAAC TGTGAGAGAATACATΠTGGTTGTTTTAA GCTTCCCATTTTGCAGTGCTTTGTAATAC AGCGGCAGCCCTAGGAAACGAATACATC TTCCACATTAGTTTTCTATATCAAGTTGTT TTTTCTCAAGATTGTATTTCTTCCAATCTT RS7085261 10 102199801 CTGCCTCAGCCAGGTGTCACTTATTGAA A/G GAATATTCAGGAAACAGGAGAAGCCCAA SEQ_0455

GTTGATGCAGTCC I I I I I GGTTGTGCAAA CTTGACAGAGACACTATTTTCCTCTCTGT

GACACACTCGGCTTCTATCTACTACTCTA CATTCTCTCTCTCATCCAAATTTCCAGGG

GGGCTTCTAGATTCTCTAAATC I I I I I CT AAGGAAACCTGATTGGCTCAGCTGGGGA

CCTTGTCATCTATΠTAGAGCTCATTTTG GAGTACCCACTTAGTTACCCACTTAGTTA

CTATCTCGTGTTTCTCCTTTCTGCTCTCA CATCATTTATGGTCAGGGCTGAGGTCAT

CTATTCTTCTTTTGAAAAAAAATACAT GTGGTACAAAATTACTGCCAGAGGCCCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7085439 10 102200090 GGAAACCTGATTGGCTCAGCTGGGGAGA C/T ACCCTTGTGTATAATCTTTATAAACATCAT SEQ 0456

GTACCCACTTAGTTACCCACTTAGTTACA ATGATTACTTCCTTAAAATAAATTCCTAAA TCATTTATGGTCAGGGCTGAGGTCATGT GGTGGAA I I I I I GGGTCAAAGTGTATTAA GGTACAAAATTACTGCCAGAGGCCCCCC TATGATTAAAGTTTTAAATTCATGTTATCA ACTGGAGGTTAGATAGCCTATAAACTGC AATTCATCTCAAAAGCATTGGATTAATTC CCATGAGCTGGGCAGACACTCCAAAAGC ACACTCCTATTAGCAGTATATAAAATAGC ACTCTGCTATTAGTTGTAATAATTCAATG CATTTGACAACACAATATTGGATCTTATTT AA TTTTAAATCTTTGCCAATTTGATGAGTTAG GTGATGTCTTGTTATTTTAATCTTCCTTTT ATAATCAGTAAAGGTAAA I I I I I I I I I I I I TGAGACAATGTCTCACTCTGTCACCTAG GCTGGAGTGCAGTGGCACAATTTTGTCT CACTGCAACTTCCACCCTCTGGGGTTCA AGTGATTCTCCTGCCTCAGTCTCCCAAGT AGCTGGGATTACAGGCAGCTGCCACCAT GCCCAGCTAA I I l I I I GTA I I I I IAGTAG AGACGGGGTTTCTCCATGTTGGCCAGGC TGGCCTCGAACTCCCGATCTCACGTGAT CCTCCCACCTCGGCCTCCCAAAGGGTTG AGATTACAGGAGTGAGCCACCACTCCCG Ul GCCAAGGTAAATAGTTTCATCTGCTTCTC K> AGGTGTTTTTTATTTCTGACTTTTGAAGA GCCTATCCATATGAATTTGCCATTTTAAA ATTGGACA I I I I I CATTCTAATGGTTTGTT ATAGCTCTTTATATATTAAAAATATTTACC M I I I I G I I I I G I I I I G I I I I I I GAGACTC ACTCTGTCACCCAGGCTGGAGTGCAGTG GCTCAATCTTGGGTCACTGCAACCTCTG CCGCCGGGGTTCACGCAATTCTCCTGCC TCAGCCTCCTGAGTAGCTGGGATTACAG GCACCTGCCACCATGCCCAGCTAA I I I I I GTA I I I I IACTAGAGACAAGGTTTCACCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12219789 10 102203768 TTGAAAACAAAACCTGATGGAACTGATAA AJG GAATAAAAAAAAGAAAGAAAAACTGCCAA SEQJD457

ATTTATTTATAATTCATTGTACCTCAACCA TTCCTTTATTAGACTGAAAACAACCCAAA

TTGAGATAAAGACTCTATCCTCCAGTATC TATTGAGCAAAATAAGATTACTTGTATAC

AAGGTGATTAAAATAGCAATACTTAAATC CTGACAATTTATACTATCCTGCTCTTTAAA

CAAATTAAAATAAATTAAAAAGTTGACTTT AAATTGAGAGTAAGAGATACATATATATA

TTTTGTTCCCTTCTTTTCACAGGTGTTGA I I I I I 1 GAGACTGAGTCTTGATCTGTTGC

AAAAGTTGCCTTTTAAATACCCGA CCAGGCTGGAGTGCAGTGGTGCGATCTC

GGCTCACTGCAACCTCCGTCTCCCAGGT

TCAAGTGATTCTCCTGCCTCAGCCTCCT

GAATAGCTGGGACTACAGGCACATGCCA

CCACGTCCAGCTAA I I I I I GTA I I I I I AG

TAGAGACGGGTTTCACCATGTTGGTCAG

GCTGGTCTTGAACTCCTGACCTTGCGAT

CACCTGCCTCAGCCTCCCAAAGTGCTGG

GATTACAGGCATGAGCCACCGTGCCTGG

CCGAGAGATCTTTAGACCCTAACATAGAA

AGTTGTATAGAGGTTCCAAGATGGCCGA

ATAGGAATAGCTCCA

W

(Jl

W

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs1539089 10 102211414 AATGAGTATCCATCACCTCAAGCATTAAT C/T GCATCACCTTTCTTAAGGTCTCCCTGAGA CCTTTGTGTTACAAACAGTCTAATTATAC CAATGGTCTTTGTTCTTTTCTTTTAACCTT TCTTAGTTACCATGTACAATGAAATTATTA GTTCCTCTTGCTCCAAAACCCTCTCTGGC TTGACGATAGTCACCCTGTTGTGCTGTTG TAGACTGAACCAGAAAATAAAGAATTAAT AATACTAGGTCTTCTTCATTCTTTCTAACT ACACAAATTCACTTTCTCCATTACCTAGG ATTTTCACACCTTCTACTTTAGCATC CCAGACGATTTAGGGGGTCTTCACCTCA GTATCTTAACTGTGTAATTTTGTTGTCCA CATGGAATCTTCTAGACCAAGTCTTTATT TGGGGCTCCAAACCTTATTGTGAGATGA GCTTGGTCAGTTGTGGCTCCTACACAAA CAACTTTAGGTCCTCCTCTCTCTTCATTC AGAAAGGGAGCAGTAGAGTCTATTTCAG GCCAAGAGTCAGGTTCTAGGAAGATAAG GAGCAATGACTCCTGGATTTCAGCCTTG ACTTCTTCCCTGACCACAGTTTTTGCCAT TTACTTGACTAGAGAACTCCTAAGGGATG CAAAAATTCATTGGGAGGTAGAGCAGAT TTGGGCAGTTTTTGTGTAAAAAGGGAGA GCTAATTTAAAATGAGTTCATTGAGGCAC TGTCCTATCCCCTTAGAATTTCTTCCACA

Ul AAGGAGAAAGTTAAGACTTTTATTGTTTG TTTATCTATCTGTCTGTCTGTCTGTCTGT CTGTCTGTCTGTCTGTCTATCTATCTATC TATCTATCTATCTATCTATCTATCTATCTA TCTATCTATTTA I I I I I AGAGACAGGGTC TCGCTATTCTGTCCAGGCTGGTCTCATAC TCCTGGCTTGGCGAGATCATCCAGCCTT GGTCTCCCAATGTGCTGGGATTACAGGC GTGAGCCACCACGCCTGGCCTACTTTTA TTGTTTTGCACAAAATTAATACATTCTTAT AATAAAAACTTAAACATGACAGAGATAAA TAGTGCAAATCCCCTTTGATGACCTGCCT rs3793772 10 102212815 CCCAGCTCCAGGTAAGAGTCCAGGTTAC A/G AAGCCCAACTTCCTTGGTGTGTAAGCGA SEQ 0459 TTACCAGCTGTGGCTGAGTTGGAGGACA TCCCAAACAGAGTTAAGGGGAGGTGAAA CAGGTGAAAAGACAGATGTACACAGAAG TGGAGCTGCCAAACGTCCAAAGAAGAGA GCTTTGAAAGAAACATAATCCTCTGGAGT TTATCTACTTAATTAAAG I I I I I I I I CCCC AACAGCTAGAGAAAATTCCAAAAAACTGG TCTAAGTCCTTCAGCCAATCAGAACTCAA GAGATGGGTAAGCAAGACGGAGAAATAT GTGCCAGAGAAAGATTGAGTCGATCAAA TCTCCTCAGTGCCAGTGGGATGGAATTC AGAACACTCCAGGATCCTCCCAGACAAA TC T

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3793771 10 102212947 ACTAAAATCAGCCATAAATTTAGGAAGAG C/G AGATGTACACAGAAGGCTTTGAAAGAAA SEQ_0460

CCCTACCCCATAGAACAG I I I I I CCTAGG CATAATCCTCTGGAGTAACAGCTAGAGA AGAGCTATCAAGGCTTCCTACATTTCTGG AAATTCCAAAAAACTGGGAGATGGGTAA AAATGAAATGAGCTTTACCCAACACATTA GCAAGACGGAGAAATATTCTCCTCAGTG CATACACTTACCTATTCCCAGCTCCAGGT CCAGTGGGATGGAATTCTCAAAGCCCAA AAGAGTCCAGGTTACTTACCAGCTGTGG CTTCCTTGGTGTGTAAGCGATCCCAAAC CTGAGTTGGAGGACACAGGTGAAAAGA AGAGTTAAGGGGAGGTGAAATGGAGCTG CCAA

ΓS1 1 190568 10 102214267 TAGTCCA I I I I IAATTGGCATTTTAATTAA C/T GGTGTGAAGAATTGTTCTATAAAAAATAC SEQ_0461

ATATTTCAATGTTAAAAAAAAGGTCTCTCT CTTTACTGTGTGTTCCCTTCCCTGCTGGA TCTCTCCCCCTCATGAGAACAAAAAGACA GGGGGTCATGTTCATTTCATTCCGATACT AAAGGGAGAGGAGACTATTTCAGAGCAT GACACAGCCACACTGAAAGGTGGCTGG TTCTACTGATGTTCATGGTATTCTTCAGC GTTGCTTGTCTGTCCAAATTCAAGTGTCT TGATTCAGTATCAGCAAAAGAGAAACAC GGATTCAAAAAGAAAAAAGGAAAAAGAG GAGATTCCCTTCCCTAGTCACCAGGG ATGTGAAAGAAAGTTCTAATTTAAGAAAA rs11190569 10 102217399 ATGAAATTCTTATACTCTCCAGGCCAAAT A/G TTATCCTGTCTGGTATTTCCTCACCTTAA SEQ_0462

TTACACCACCCTACATTAGGAGGAATTTC TCCAAGGCATCTGGTGGAGCCCAGATTC CCCTTCATTCAAAACTGCAATTACCATTT CATAGATTATTGCTTTTCAGAATAATTGG GCTGCTCTAAATCTCAGTCC I I I I I CTGT TTTTGTTTTAAAATTTTCATACTATGGGAA AGTCAGGTTCTTTAGGTTTATCGTATCAC AAACATG I I I I I ACAAATGTTGAGAACAG Ul ACTTTGAAGGTTCCATTATCCAGGACGCT CATATATAACAAACCCCAATAACTCAGCT AAGTAGTGAATCAATAGATTGTCCAC TCAACCGTTATCAATCTCTGACCAATCAT GTTTCACCTATACTTTCTGTAGCA I I I I I A ACTGCATATTCTCTTAGTCTGAATCTTCC AAGTACTACCATGGTTCAAAACAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1417823 10 102217876 CAGGCTTTGGCACTTTAGTGCCA I I I I I A C/T AACCACAGCTCCAATAGAAATAAACACAA SEQ 0463

CTGCTTAATGGAATTAATCCAAATAGATG ACATGTATTTGAATGACTTATTCCCTTTTG GTAAAATGTTCTCTCCTCAATCTGATCCA CTAATCTGTATTCTTGATCTTCTCCTAAG ACCATCAATTTCTACTGCCTTTGCTAAT GGCAATGGGAGAAATGTACAATGTTCCC CAAACTTCATTCTAATTACTGGCCTGAAT CTCTCAGACACAGGACAGATAATCCTTTT GCTATCCCTCTTCTTCCTGTTTTGAACCA TGGTAGTACTTGGAAGATTCAGACTAAGA GAATATGCAGTTAAAAATGCTACAGAAAG TATAGGTGAAACATGATTGGTCAGAGATT GATAACGGTTGAAGCTGAGTTATTGGGG TTTGTTATATATGCTGTTCTCAACATTTGT AAAAACATGTTTTTCCCATAGTATGAAAA TTTTAAAACAAAACCAATTATTCTGAAAAG CAATAATCTATGGAATCTGGGCTCCACCA GATGCCTTGGATTAAGGTGAGGAAATAC CAGACAGGATAACGT rs 10883497 10 102218509 CCTGCCACAGTCCTCATTTAGATGCTAAG Cn GCTTGTGAAGGAATCTGCCTGAGCTTCT SEQ_0464

TGCTGAAGTGCTTTTCTGTAGCTTAGCGT TTAGCAAAGATCCATGGTACAGAGTTGTC TTCTCAGCAGCACTTGCTACAATACATAA CTGTGGGCTATTACATGGCCTTTGCTAAC AGAAGGAAAGAAATGAGGACAGGGAAGA AATTGTTTGGCAAGGGCCGGATTTGCGA TAGCCTATCACTCTATAAAATATCCTGGA TAATGTGGGATTTTAATATACATTTTAATA ATACAAATGACGTATCAGTTGCAGGGAA TAAGGACTACTGCTAAGATTGTCACATCT AAAGATGATCCCCCGAACATTTGTGCTT GTTTAACTTTAAAAAA I I I I I I I I GTC rs7900678 10 102219006 TTACAGGGCTGAACTCCCTTTGAAGAAA C/T AGCACTAGCTACTTTCATGTCATAACTCC SEQ_0465

GAAATGGACTTTAATTTGGTGAAATAGTT TCACTCTCTGCAATCTGGCTTGTGTTCTA ATGGGAATATGACCAAAAGCTACACATTC TTGCCATACTTAAATAGATCCCTCCACTG CTGAA I I I I I CTTTCTATACTCATCTTGAA ATACCAGCTTTGTTCCCTCTTGACATATT AAATACCTTCCTCTGGCCCCAATCTCTAC TTTAAGTAGGAGGAAATCTGATTTTGAAA TGCAATCATTTCTCCTTTCTC IT I I I I CTT GTCTGAATACTTCTCTTCCCTTTAAGACT TCAATGCCATCCTCCCCCAACCAGT TCAGATACCTTGTAACTTCTACCTCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190573 10 102223162 GAAAGGGAAACCTTCATATGAAACAGAG CfT ATTAGCATTCACTCCCCGTTCCTCCTCCC SEQ_0466

AAAAGTTGCTGTGAGGCTTCAAGGTGTG CTCAGTCCCTGGAAACTGTGAATCTAGT

CTGGTTGTGGCTTCTGCACTGGTACTTAT CAGTTTCCATGAGATTGCCTATGCTGGA

TCAAGAATAAGTGAGATTTTTAAATAATA CATTTGATATAGATAGAATCATATCATTTA

GCTTTATTGAAATATAATCTACATACTATA TGGCCTΠTGTGTCTGGCTTCTTTCACTC

AAAGGCACCCTTTAACAAATCAATGATTT AGGATGATATTTTCAAGGGTCATCCATGT

TTTTTAGCCAATTCATGGATTTGTGCAAC TGTAGCTTGTATCCAGTACTTCATTCCTT

CTTCACCACAATCCATTTTAGAACATTTTA TATATGGTCAAAAAATATTCTATTATGGG

ATCACTTCAAAAAGAAACCCTTTATT TTGGACATGGTGGCTCATGCCTGTAATC

TTGCACTTTGGGAGGCTGAGGCAGGCG

GATTGCTTGAGGTCAGGAGTTTGAGACC

AGCCTGGCCAACGTGGCCAAACCCCATC

TCTACTAAAAATACAAACATTAGCTGGAC

ATGGTAGTGCATGCCTGTAATCGCAGCT

TCTTGGGAGGCTGAGGCACAAGAATTGC

TTGAACCCAGGAGGTGGAGGTTGTAATG

AGCCAAGATGGCGCCACTGCACTCTAGC

CTGTGCAACAGAGCAAGATTCTGTCTTAA

AAAACAAAAAAAAAGGTGACTCTTCATGA

I I I I I GTCTGAGCAACTAGGAGGAACAGT W

CCTTTACTTAGATGGAGAAGACTACAGAA <I

GGGGTAGGCTTGGGTGATGGCAGCGAG

GATCAGGAGTTCAGTTTTGGACACGTTAA

GTTTGAGATGCGTATTAAACACTGAAGGA

GAGATGCCAAGAATACAGTTGGATATGC

AAGTCTAGAGTTCAAGCAAATGTCTGAGA

AGAGCTGGGAGGGTTCAGGAAGTCATGA

ACCCTTTGAATGGTCCTGAATCTGGGTAA

TATTGTCAGCAACTGTACAACCTCATGGG

AAATGGGAAGCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190578 10 102228943 AAACAAGTTGGTGTCTCTGCATTATATTC C/T ATTACAGATAGAAAGATTGAGACCCAGA SEQ 0467 TG I I I I I G I I I I I I I M I CCCTTATAGGTC GGGTGTTAGGGACACATCTAAAACCACA GGTGAACAATTTCCTGATGACTGGTCCA TAGCAAACCACTGTCAGCGCCAAGATAA AAGGTAAGAACAAATTCCATTAATTGATA GAACGCAGGAGCACTGAATTTATGGCTA TGGATTTCACTAATCTTAGCCTGTTGACT GAATTTCCAGAGCCATAAAAGTCAACAG AAAGATGATAAATGCAGA I I I I I CATTATA CCTTTTATAGGTGTCAGGCTGCAAAGTCA TCCACATATTTTATTATGCTGTATA CACATCCTTCTCAGTGCCCCGTGGTGGG ATGCAGTTTCCCATGTTTAAAATGCTGGA ATTGTACTACATGATCTTTACATTCATGG GCATTTTCAGTTCCAAAATGTTGTTTTCTA AGATGGTCATGTGATGAGAACTCCTTAAA TTTCATGAATTAGGTGATTTGGGCTCATT TT rs2295770 10 102229819 AGGCTTACCTGATTTACTCCAGCAGTGT A/G ATAGCCCCTTGCCTCCTCGACACCCTTAT SEQ_0468 GGCAGCTGGTGCCCAGAGTGGTATTGAA TCCTCACCTGCTCTCTTCTCTTAGGTCAT GAATGCAAGTATCAGTTTGCCTGGGACC CTCCCTCTCCAGGATCTTCTCTTTTCCTT GCTGGAACTGCCCTGAGAGAGCCCTGCA TTCTACTTCC I I I I I CCCACCTGTAGAGT GCTGTCCAGCCATGGTGGGCTTCGCAGT F I I I I CTTTCTTTCTCAACACTCTCATTGC GGTAAGAAAAACCTCAGCCACAGCTCCC TCAACAAATGGATCTTGCCTTACTCCCAA TGGACCCTCTGGTCACAGGTTAGAGCCC TCCCATACCATCCTTGGCCTCCCAG Ul CAGG 06 rs12355721 10 102234901 AATGGATACCAGATTCATTCCAGTTCTAC C/T GTGGTCCCTTTACAAAGTAGACAACTCCA SEQ_0469 CAAGAAAACATGACTGAGATGCCTTGGA GAACTGGTGCTTGGGAAGACATCTTTGA TCTGTATTGCTTTTCCCTTCCTTTTGCAAT GGTCAGCCAGTCAAACCTTTTGTGTTACA ATCCACTTGTTCATTTGTTCATTCAACAAA GATTTAAACTGATGCTGAGAAAGATGACT CACCAGAGTAGAGATAGTGGTGAACAAC GGCTTCTTCCCCCAACTAGTAAGTTACTG CACCATTGCTGCATCACGGAGTTTMGTT TGGGGAGAGTGCAGAGCACAGGCCCCT CTCATCTTACACTCAATTGCCAGGGC TCCACCTCTTGTGTGCTCTTCAGGAGCC

CATCTGTCTCAGCCAGAAGACAGAAACA

GAGGGAGGCCCTGAGAAGTGACAAGGA

CATTGGTTGGGGTGGGCAAAACACTGTC

TCCTTCCTGTCCCTGGCCTGTGAGCCTA

MCACAGGCAGAGCTTTTTCTTTTTGAAA

AGMTCGCA rs2298075 10 102237398 CTGCCAGGGTAGGAGCTGGGTTGGGCT GfT CTGTCCTCATCATCGCTCATMGCTGCTG SEQ_0470 CACTAACCTAAGGGTCATTCCCTCCACA GTCTAAACCAGGCAGCCTCTCTTGCTAG GCTCTCACCTCATGTCGTGGCTGGGCTC GAGGCCACTTCTGCTGTTACATMCTCCT CATGAGGTTGCCCGATGTGTGGATGCAG CCCTGCAGMGAGGGGACTTCTGCAACA GAAGCTTTGAGCAGGGCCTTGCAGTGCA GATTCTGTTTC I I I I I CCCGACTCTTTTCC TGCCCAGGTGGCGGGCTGTAGCAGCTT TTGCTGCCAGGTATGTGATGCTGTAGGC CAGCGAGGTGTCCAGCTTCATGCCTATC TTGGCTCCAMCCAGCTGAGTGCCTGCT CTGAAG

Supplementary Table 3

SNP Chr Position 5' Flanking Seαuence SNP Base 3' Flanking Sequence SEQ ID rs3750720 10 102238874 GATTCTTCCCTCACAGCCCCCTGTCTCC A/G TCCTTACTGCAGAGAAAGGGAGGCTGCT SEQ_0471

AGTGTGAGTCATGCTCCCCCAGGAGTTC CATCTCCCCAACTCTGCTGTAATGGGAA

CAGGAGAACTCAGCCTGCAGGTGACAAG CAGTGTGACTGTGAGTCACTGGGGACTA

GACAATGTATTCCCCTCCCTTGGGAAAC GTCCTTAGGGAAGCCATGAGMGGACAG

CTTCCAGCCCTCCTTGGGTGCAGGTCAT CTTGCCCCTCTGGCCTTTCTCCCTGCTTC

GGTAGATGGGCCTCATTCCTCAAGGCAT TTTATCAGCAGCTTCAGCACCTGCCACCT

GTGCTGAGGGAGACTGGGGGCAGGTAC GAGAAGATGGAAAGGAAGGAGCTGCCC

CAGGT CCA rs3750719 10 102238940 AGAGACATTTATGCCCCCAGCACCAATTA C/G GTCATGGTAGATGGGCCTCATTCCTCAA SEQ_0472

CTGCTCCAGTTATGAGCCTCACCCCTGA GGCATGTGCTGAGGGAGACTGGGGGCA

GCTACAAGGGATTCTTCCCTCACAGCCC GGTACCAGGTGTCCTTACTGCAGAGAAA

CCTGTCTCCAGTGTGAGTCATGCTCCCC GGGAGGCTGCTCATCTCCCCAACTCTGC

CAGGAGTTCCAGGAGAACTCAGCCTGCA TGTAATGGGAACAGTGTGACTGTGAGTC

GGTGACAAGGACAATGTATTCCCCTCCC ACTGGGGACTAGTCCTTAGGGAAGCCAT

TTGGGAAACCTTCCAGCCCTCCTTGGGT GAGAAGGACAGCTTGCCCCTCTGGCCTT

GCA TCTCC rs2273694 10 102246486 CCTGACCATACCTAGGTGAAGGCAGCAG G/T ACTAATTGTTTCATGTGCGACTTTTGTCT SEQ_0473

ATGATGACACGTAAGAACTGTGACAGAG CTCCATGAGTCTGTGACCCCCACTTTCT

AAGGGCCACCTGGCCTCACCTCCCAAGC GTGGTCACCCACAGAACACCTGGAAGTT

TGTTAGGATTGGATTTAACTGGACCCATC TAGATCCACAGAACTTTCCACAGTAGCTA W

TGGGTCTTAGA I I I I IGTACATCTCTACC ATAGAAGGGCCAAGCCACAATTACTCAA «

TCTTCCTTTTGC I I I I I IACCCTTTCTGCT GTACTGAATACATCTGTAAAACCAAACCT

TATACATCACCAACCACAGACTCTGTCA GAAATAGGAAAAAAATTATGAAGACTAAC rs2273695 10 102249558 AGAACACAGAAAAGATTCCATTAAATGAA A/G CATGAGAATTTGACCTTTCATTGACTTCC SEQ_0474

CATAAATGACGCTCTTCCTACAACAAGCT TAGCTCTGTTACCCTGGTAGTCTGGTGA

GGGTATCTGTGCCAGTATACCCAATATA GAGTAAAATGTCAGCTGTTCCTAGGCAAT

GTTCTTTGTACTACTAGAAGTGCCCTCAG ATGCTTGTGATTGGTAACTTGCATCTGGA

CAGTCCAATGCCATCTC I I I I ICCTCCCT CTGGAACTATGTAACCTAGAAATAATTAA

GGATCTGACTTACTGATGGGCTATCAGC TGTGAACAACATGCTATGCATTTCCCTGT

AGTGTTAACATAGCCCCCTGCCCTTTGC TTGCAGTGGCTCTTGTAACTGGACAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4604805 10 102251399 ACAAAAACAAAAAAACCCAGAATGCCCT C/G CCTTTCTTCCTTCAGATCTCTCACTTGCT

GTCCTATAGGTCCCTCTGTCCTATAGGTA CATTTCCTTTGATAGGTATAGTACTCCTC CCACTGTCTCCTTTGTTTAGCGGAGTAAA CTGGTGTCACAGGAAACTTGAAATTAAAT GGCTGAACTCCTGACCACTCCCTCTCTTT GAGAACTGGAACTGAACCCATGCCTCCA ACCATCTCACCATTCCTGGAACTTGTATC GTGTACAGTGGCACCTGAACCCTAGGAC CTGCTTATGACAAAAGCATCATTTCTTAT CCACTCCAAGGACTTGCCTTGGGTTACT TCTTTTCTTCCCACATCATTCTCTGGCTT TGAAACCAACTCAAAGCCTTCTTATGACA CACTGTATAGTCAAGATCTTTCTCAAATC ATATGTCCTTCTAACTAATG I I I I I CCTTT CTCTTTCTCTAACTTCCTGATGTCCACCT CTCCTC I I I I I CTCTTTCCTCCC I I I I I I C TCATAAAGCTCTACTATGCCTAAAGCTCA TTCCTTCCCATTACCTTATCTGCCCTTTG AATTTCAAGTCCCTCTCAGATGCCCTGGT GCATGATACCGTGAAGGTCTTTGCCTTG ACAGGCCCAATCC I I I I I GCTTTCTTCTA GCCCTGGTAAAATACCTAGGACATCAAC AACAATTCCAAAAACTTGCACAATCATCC CATAGTAGCAACAAAAGAAAACATCTCGT CACTGACTGACCAGTCAGCTACTT GTATTCCCCATCTTTCCTAGCCTCTT rs7477246 10 102251528 CC I I I I I GCTTTCTTCTAAACAATTCCAAA C/T CTGAACCCTAGGACCCACTCCAAGGACT SEQ_0476

AACTTGCACAATCATCCCACTGACTGACC TGCCTTGGGTTACTTGAAACCAACTCAAA AGTCAGCTACTTGCCTTTCTTCCTTCAGA GCCTTCTTATGACAATATGTCCTTCTAAC TCTCTCACTTGCTCATTTCCTTTGATAGG TAATG I I I I I CCTTTCTCCTC M i l l CTCT TATAGTACTCCTCCTGGTGTCACAGGAAA TTCCTCCC I M I i I CTTCCTTCCCATTACC CTTGAAATTAAATGAGAACTGGAACTGAA TTATCTGCCCTTTGGCATGATACCGTGAA O CCCATGCCTCCAGTGTACAGTGGCA GGTCTTTGCCTTGGCCCTGGTAAAATAC CTAGGACATCAACCATAGTAGCAACAAAA GAAAACATCTCGTGTATTCCCCATCTTTC CTAGC rs7071271 10 102254814 AAAGAAGTCATATGTAACTGGAACATAGA A/G GTTAGAGAAAAGATGGAATCTCAGGCTA SEQ_0477

GAACATATGAGAATGAGACAGAAATGGA TTTCTCCACAACCAAGAGTTCTAAGGCAG AAGGTAAGTGGAGCCCTGTGCAAATTTA TCAGCTCCTTTTAGACAGGACTGGCAGA GCCTTGTCTATAAAGCAATGGGAGGCTC AGATATAGAATGGGTGAAGTGAAGAGAA AAACGTTTTGAACAGAGAAATGACAGAAT GGAAGCTATAGTAACTCTCTCCTTGAGA AAAATGG I I I I I I I I I I GCCTTCTTTGTAG GGTAAAGTGGGATCCATTCTGAGACAGA TTCCTTACTACCAGTCCAGACACGTAAG GGCAGTGGGAATACGTCTGCTACAAAAC TTA rs2295772 10 102255173 AAACACACACACACCTATACATCCACTAC A/G TGCTTGTGCCACTTGCTCTGGCACCTGC SEQ_0478

ACTTACAGCAAATGAAACACCTGTTGGTC AGTGGTGGGAGAGGCTGGCCTTTGCTGA TTCTAATCCATTTGGGGGG I I I I I I CAGG AGGAAGAGGAGATCTGGGGGGAAAAGA GGAGGTATCAGTG CACCTGCATCGCCATCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2295773 10 102255805 ACATTGTGGCAGAAACTAACATCCTTTCA A/G TGCTGGACTTCCCAGCTCCTACCCATCA SEQ_0479

GGAAGATGGGCACTAGGGCAAAGGTGC CAGAGTACAAACTGATCCAGCCGTTGAA

AGCCCTCCCAAACCCCGGGCCCTGGTCT GGAGGCAGCAGAGAACACTGAAGGGTC

CCCAATCTCCAATATCTCCGCTTCTCAAG CCGAGGGCACCACTGCACATCAAAGCAC

CCATATGTCTCTCTCCCACAAACAGAGAC CAGCTGCTCTGTGTTGGTAGCTTATATAC

AGCCCCTTCCCTCCAGCATTCTCTACCAA CACCTAATATGAGGGAACACACCATTAG

GCCCTTCAAACCTTGTCAGCCTGTCTCAT GGACAGTCCATGAAACCCAAAACACATG

GCTG rs2295774 10 102255837 AGATGGGCACTAGGGCAAAGGTGCAGC A/C GTACAAACTGATCCAGCCGTTGAAGGAG SEQ_0480

CCTCCCAAACCCCGGGCCCTGGTCTCCC GCAGCAGAGAACACTGAAGGGTCCCGA

AATCTCCAATATCTCCGCTTCTCAAGCCA GGGCACCACTGCACATCAAAGCACCAGC

TATGTCTCTCTCCCACAAACAGAGACAG TGCTCTGTGTTGGTAGCTTATATACCACC

CCCCTTCCCTCCAGCATTCTCTACCAAG TAATATGAGGGAACACACCATTAGGGAC

CCCTTCAAACCTTGTCAGCCTGTCTCATA AGTCCATGAAACCCAAAACACATGGCTG

TGCTGGACTTCCCAGCTCCTACCCATCA CAGCTGAGATTCTTCTACCCTCTCTCTCC

CAG CAT rs7080356 10 102256725 CAAACCAAACCTCAGAGCCTGTGCACTA A/C CCCAAGGAGATACAAAGGCACCATGGCC SEQ_0481

TGCAATGTACCACTCTGCCTCTCTTAGAT CTTTGGTTAGAAAGAAGAGATTGTGGAG

CACTGCAGGATGACCTGCTTCTTTTCACT GCTGGATAGAGGCCTCCACAGGATAGAC

GATTAGACAGTAGAGATTATGAATCAGTA AGGAGTCAAGTTG I I I I I ATGAAGAAATC %

TGAATCACACAAACACTCATCACTATGGG CTGGAGGAGGCAAGCTCATCACCTAAAG ^

TGCTTTTAGCCCAGGAGGTAGTAAAGAC AAATGAACATTATCCTCATATCAGAGCCT

CTAACCATCTAAAGTCCCCAAGGAGGCC GGAGGCTAAACACTGGTTCCAGTATTTCT

AGGCACAGTGGCTCATGCTTGTAATCCC C

AACACTGTGCAAGGCCGAGCGGGGAGG

ATCACTTGAGCCCAGGAGATCGAGGTCA

CAGTGAGCCTTGATCACGCTACTGCACT

CCAGCCTGGGTGACAGAGCAAGAACTG

GTCTAAAAAAATAAAGGT rs3793706 10 102259075 ACATACCACCCTAGGAAGAAACAGAGCA A/C AAGTCGAGGGCTCTGACAGCCCCCGTGT SEQ_0482

AGAAAGGAGGAAAGAAGCCCAAATTTGG GCTTCTGTTTCTGAGCAATCACAGGCTC

GGCTATCAAAAGCCTCCCCTGAAACAGC CTTCCCCGAAGACAGGATGTGGGTCACA

CTGGAAAGGGGTCAGAGTTACAGACTGG TTGTATAGAATAAGCATGCCATTGTCCCC

AGGCCACAAATGAATGCTTCCACTCAGA GCCGCCAACAATAACCCCGGAGCTTTCC

TCTGTTGCTCCCTGGCTTGGCCATGTTT AGAAGCCCACTGCCAAAGCTCCCCCAGA

GACTAACTGAAATGTAGTACCTGGAAAG CCAGCTTGTGAAACCTATAAAGAGGAGG

GATT AACTGGCATCAGTACAAACTTAGGTTCAT

GTCAGTAAGCACAGGATGGGCATCTCTG

TCAGCTTCTGCCATTATGCAGGCAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3763695 10 102259196 ATGAATGCTTCCACTCAGATCTGTTGCTC A/G CAATAACCCCGGAGCTTTCCAGAAGCCC SEQ_0483

CCTGGCTTGGCCATGTTTGACTAACTGA ACTGCCAAAGCTCCCCCAGACCAGCTTG

AATGTAGTACCTGGAAAGGATTCAAGTC TGAAACCTATAAAGAGGAGGAACTGGCA

GAGGGCTCTGACAGCCCCCGTGTGCTTC TCAGTACAAACTTAGGTTCATGTCAGTAA

TGTTTCTGAGCAATCACAGGCTCCTTCCC GCACAGGATGGGCATCTCTGTCAGCTTC

CGAAGACAGGATGTGGGTCACATTGTAT TGCCATTATGCAGGCAGCCCCACCCCTA

AGAATAAGCATGCCATTGTCCCCGCCGC GCTGGAACTTGCCTGTCTCCTTCATTTCC

CA CAGACAGAAGGGATGTATCCTCCGCCCA

GTCCTGCCCTTTCTCTGAAAAAATGTTTC ATCTACGTTACACCAGAAGCCAGGA rs 10509744 10 102261569 TTCATGTTAGTGAACTAAAGTGAAAAGAG Crr AGTACTCCAAGCTGGAGAATGAATGGAG SEQ_O484

TTTGTCCACATTCAAGCCAAAATAACTTG CATTGGTTGTTTGAGAGGAAAGCTACTTT GGAAACTCAAGCCTCCCTAGAAGTCAAA TCTGAATGCCTACGCATCTACTATGAATC CAGAGTGATTAAGG CTCAATTTACAGTG

ΓS4244338 10 102262792 TGGTTGAGGCATGGGTTTGGAGAAAAGA A/G ATCATCTAGGTCAATAGTTTATGATACTG SEQ_0485

GCAGGCAGAGAATGGGGAAGATTTTGAA ACTGTTGAGCATGTGACCTAACCTAGACT AGGTGCATGTTTAGTTGATAAAAAAGAGA GGAACAGAATGAAGTGGGTGTCTTAGAC TATAGGAAGAGGTTTAAAAATGGAAAAAT CCTGGGTGTCTAAGATGATTTCTTCAGAA GAGGAAGACTACTAGAAAATAAAAGGGA AGGCCCCAACAGGGCTGTGTCAAAGGTA ATAAGAGACTGAACATGAAACCTGAATTC ATCCCTTTGGGATTGAGGTCTTTGGGAAT K> AGATCTCAGCTAGTTTCTTAGAAGTTATC GTGATTTAATCTTCCAACACAGTTACAGA TGGTACAATCTCTTCTTTATACATAAGTG GGTGGGAAAAGAAAGCAGAGATAAAATA AGGGAACCTAAGATAACTGACTTGATTTG CTTATCAGTAGGGTTAACTGTGCTATTTA CCCAAGTCACACAGCTCTATTAGTATTAT TTCTGATTACTGGCCCCAAATCCCTACAG GGCCAATGCTACTGCCCCACACAACTGT AGTGGAGCAGGAGTATGAGGTAAAGTTC GCCTTATGCCACAGCATGCAGAAGACAC ATGACTCCCAAATTCAAACTAACAGCTTG AGAAAAAAAGAGAGAGGAAGACAGAAAG AAAAACCCTTAAGACACTAAGACTAACTG CAAAGGACGAGTGTCCCTCTATCTTCCC TAACTGAAGTGCTGGATTTGAATGCTG T rs11 190589 10 102265461 CA I I I I I I CTGATGATATAAACATTTGGA A/G AGGAGAGGATCATTCGTTCTCTTCCTTGT SEQ 0486

GACCATTGCTTCAGATTGTAAGCCTCAAC TGGCAGAGAGGGTGATATTGTGTAAGGT TTTACAAGACCTTTAGAAGAAGGGCAGA GTTTATCTTCACAAGAGCCAAGGGAGGA ATGATGGAAAGAAGGTAGGCTTTGGACA AGGAGCCAATATCTCTGGGTTCAAAGAC CAGATAGGCCTTGACTTAAATCCTAGCTT AGACCAGGTACACGTGGGTCCAGGCTTG CTCAGAGTTTCAGTTCCCTCCTATGTAAA TCTGAGGCATCTCTATCACATGCATTCAG ATGGAAATATGGTACTTATCACTTAGGTT CCTGACACTGCTATTGCTGCTGACTGGA TATTATGAGGAATAAATAAAATGTACAGA AA GCCCCTAGCACAGTGTCTGGCATGTATA CATGTGCTCAATGAATGATAGTATCTAGC GCTGGAAGCCTGCAAGAGCCATGAAATC CATGAGAACCAATCAGTGTCTAAAAGCAA T

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3750627 10 102265632 ATGAGAAC CAATCAGTGTCTAAAAGCAAT A/C CTGACACTGCTATTGCTGCTGACTGGAA SEQ_0487

AAGGAGAGGATCATTCGTTCTCTTCCTTG AGGGGGGGGGTGGTTG I I I I I IAAATCC

TTGGCAGAGAGGGTGATATTGTGTAAGG TΠTGCAAAATAAGCCCAGAATTAACTTT

TGTTTATCTTCACAAGAGCCAAGGGAGG TCTCCAACTTGGCAAAGCTCCTTCTTCCC

AAGGAGCCAATATCTCTGGGTTCAAAGA TCACTTGGCTCCTCATGAGCCCTAAGAA

CAGACCAGGTACACGTGGGTCCAGGCTT ACACACACTGCTCCCAGGATTCCACGTC

GTCTGAGGCATCTCTATCACATGCATTCA AGTATCTACCCTGTATACCCATCAATAGA

G T rs3750629 10 102265717 ATCACATGCATTCAGCCTGACACTGCTAT C^T TCTCCAACTTG.GCAAAGCTCCTTCTTCCC SEQ_0488

TGCTGCTGACTGGAAAGGGGGGGGGTG TCACTTGGCTCCTCATGAGCCCTAAGAA

GTTG I I I I I IAAATCCTTTTGCAAAATAAG ACACACACTGCTCCCAGGATTCCACGTC

CCCAGAATTAACTT AGTATCTACCCTGTA rs3750630 10 102265770 AAGACAGACCAGGTACACGTGGGTCCAG A/G AGAAACACACACTGCTCCCAGGATTCCA SEQ_0489

GCTTGTCTGAGGCATCTCTATCACATGCA CGTCAGTATCTACCCTGTATACCCATCAA

TTCAGCCTGACACTGCTATTGCTGCTGA TAGATCAGACAATACCTGCTCAAGGCAG

CTGGAAAGGGGGGGGGTGGTTG I I I I I I AAAGGACTCCTCTGTGTTTCAAGTCCAGA

AAATCCTΠTGCAAAATAAGCCCAGAATT GAAGGGTCCCTGAAATCAACCTCAAATAT

AACTTTTCTCCAACTTGGCAAAGCTCCTT TTCCAATGTGCCATTTGTGCTGAAGGAG

CTTCCCTCACTTGGCTCCTCATGAGCCC GAATCTAGCTGTTGGGCAGATGTTCCTA

T G £ rs3750631 10 102269284 GTGCAGGAGGGCACCAGCTACCCTTGG A/G GTGAACAGGGAGACCCTCATCCGGCTG SEQ_0490 ^w

CAGTCCAGTCCCTAGGGAGGACGGTCA GGGGTTCCCGTGCGGCAGGGACAGTAG

GCACAGCCTCTTTCCCGCTGTCGCCGAA AGCCGGATCCAATTCAAGGGTAGACGTA

GCGCGGCGCGCCAGGGTCAGCAATGAC GTGGAGGCCCCCGAGGCCCGGACCCGC

AGACCTTCCCGCCCAGCCCAAACGCAGC GGGCAGGGCAGGCGCGGGCCGGGGGC

GACACCGGACGGCCTCGGCTGGGCCAG TCCGCAGCAAGCGGGCTCCCCTCCGCG

GTCAGGACCAAGGCGGATGGGAAGGCG CTCTGCCGAGAAAGGAGCAGTGCTCCG

CAAGGCAGC GGTCCCCAGCG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12358187 10 102274439 AAAAGGGTGATGTGCTTACAGAACTGAA C/G TGGGCAGCCAACTGCAAACACAGCAGCC SEQ_0491

AAATGGAAGAGCCACACTGTTCCTTGCT TCCCTGCTTTCAGCTTCTCTCCTTCCAGT CTCCTGAAGTGAAGTTAGTGCTCACCCT ACATCCTGGAGACTACTCCTGGATTAATC AGCCCTACGTGCATTCTCCAGCATGGAG TTCCTAAGAACTCAGCATTCATTATGTCA CCCCTGGGGCTTGGTAGGAAGGCTCGT CTTTTCTGTTCGAAAACCCAAAATGGCTC GTCAGTGCACACAGACATACCAGCTACC CCTGCCACCTAGAGGCAGACCAAGTCAT TTCAGGACATTGATTGTCTCTGCAGAGGT CACTGTATCCCCAACCGCTAGCACAGTC AGCA TGCATCTGGTACATAGTACAGGCTCCATA AATATTTGTTCAATTAATGCTTTATTACAC CATCAAGTCCAAATCCCTTAGCAATGAAA TAAAAGCTGCCCAACCTAACTGACCAACT TACCTCACAATA I I I I I IAACACAGTGATT TCCAAATCTAGGTGCACATCAGAATTACC TGGGAGCTTGTTAAAAATACCGCTTCTG GAACCCTACTGTGATGCTACTGAATTAG GAGCACCAAGAAGTGGGGCCTGGGAAT CTGGG I I ITT AGCAAGTCTCCAGGAAAC CAATGCAGCCGGT rs4919468 10 102278333 TGACTGTACTCTGATTCCCTCATTAGATA C/G CTGGGTTTTCCCCAACAAATCCAGGTTCA SEQ_0492

GAAAATGAAAAATTAAAGTTTAGAGTCTG TCTGACACTGGCTTCGAACAAGGCTGCT AATCCAAAGTCACCCAGCTAATTGGAATA CTTGTCCACAACATAAGAAAAAACAGGAA AAAACAAAAAGGGTACAGATTAGAAAAG ATGATGACAACTAGACATATGCTACAGAA CACTCTTCTCGTAATAACTGTGTTCTTGA AATGAGTGTATAACAAGAAGAATAGAAGT CCACCCAGTTGGCATTCATCTCTGCGTC TGCTGAAACCAAGATTGAAAGAGTGACA TCAAACACCTCATGGGACCTCTTGCTAA TTAGGACAGGAAATAAAGGCGATGATAA rs 1800662 10 102279068 ACAGCACTAACAGAAAAACA I I I I I I I IA A/C AACCCAGCCGGCCTTCTCCCATCACTAC SEQ 0493

AAGAGACATACACACAAATATAGAGTACT TTGGGTGCGAGCATACCCTCTCTGTCTC CCGTTTACAAATAAGATTCTCATGACAGG ACCCCATGCCATCATCCGGGTAAGGTTC AGTCCAGCTCCAGCCTGGTCACATGCCT GTAGTCTTCCACACGCATATTATACTTCT GGATGACAGCACCTGAGCGCAGCAGAT TGGCGGCGGCGGCCCGTTCTTCTGGGG GCTCAATCTAAATGAAACTCGACGCTCTG TCCTAGGATAGGGCCCCGGGAACATGTC GATAGAGCCAAGGAAGGCTCCTGCTATT CTTGGTCATGTGGGAGGCTAGAACGCAG CGGGGGTCCTCGAGGGAGCCATTAAAAC AAGAGA CTCGGCTTCCTCATTTGAGGAAACAGCC TGAGCCAAGGAGAAAATTGAAGTCCTCT CAGCTGCAGCTGCTCACCCACCCCCCTC CCACCTCCCTCCACAGAGAAAAGCACCC ACTCCATTGACTCTGAGGGGTCACGAGA AGGTTCGGGAAAAAGGGTCACAGTCAAG CCACC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10883506 10 102279733 CATCACGTTCCGGGATGCCCTTTGCAGC C/G AGTTGGGAAGCCAAGGGTTGGATAGAGG SEQ_0494

CACTGGACTCCCAAGACCCCGGCCCTG CTGGGAAGGATAAGCGGGAAGAAGGGA GCCACCGCCATCTTCACCTTCTTCACGTT AAACCAGGCAGGTCTCTGACATTTCAGA TCCCTTCTGCACATGCGCAAAGGCCTGT ATGTTGTGTCC I I I I I CTCCCTGAGCTGA CACGGCGGCTGAGCCGGGCCAAACGTG CTTAGACCCATCCAGGGATGATGGGAAC ACGGAGGAAGCCGGGAGTGAAGAAAAG TCGGAACCTGAGCAACTCAGGTAGACAG CCGAAGGGTTCAACAGGGGCGGGGTTT CTTAACCACCTCCCCCAGGAGCTGTACT AAATACG AGTG rs10883507 10 102281265 GTAAATGACATCACTAGTTGATGTTCAGA C/T GTTGCCCCTACCTCTACCCACTGGCAAC SEQ_0495

ATAATTGCACAACATCTGCATTCAACCAA CACTAATTTACTTTCTGTTTCTATGGATTT TAGCAAACCCTGATCCAATTTAGGTCAAG GCCTATTCAGACAGTTTATATAAATGGAT AAACAGAGTTGATCTAATTTATTTAI I I I I CATGCAATATGTGGCCTTTTGTGTCCATT ATTAAGATATTATTCACATACCATAAATTC TTCTTTCACTTAGAATAATGTTTTCAAAGT ACCCTTTTAGGCCGGGTGCGGTGGCTCA TTGTCTGTGTTGTAGCACATATCAGTACT CGCCTGTAATCCCAGCACTTTGGGAGGC TCATTCC I I I I I GGGCTGTATAATATTCC TGAGGTGGGAAGATTACTTGAGGTTAGG ATTATATGAATGTACAGTACAATATTTTAT AGTTCAAGACCAGCCTGGCCAACACAGC TTATACATTTATCAGTTAATGGACATTTGA AAAAACCCATCTCTACTAAAAATACAAAA GTTGTTTCTGCTTGTTTGGCTATTGTGAA

ATAGCTGGGCATGGTGGTGTACACTTGT TAATGCTGCTGTGAACATTCTTGTATAAG

AATCCCAGCTACTCAGGAGGCTGAGGCA I I I I I GTCTGGATGTATGCTTTCTATTCTT

AGAGAATCACTTGAACACAGGAGATGGA TTGGTTATATGCCTAGGAGTAGAATTGCT Ul

GGTTGCAATGAGCCGAGATCACGCCACT GGGTCATAGGGTAACTCTGTGGTTTAAC

GCACTCCAGCCTGGGTGACAGGGTGAG TTTTGAAGAACTGCCAAATTG M i l l CAA

ACTGTCTCAAAAACAAAAAACAAACAAAC AGCAGCTGTGACATGTTACATCCCCATTA

AAAAACAAAAACAAAAAAACCTΠTAAAG GCAGTGTGTGAGAGGGTTTCAGTTTCTC

TGTACAGTAGTTA I I I I IAGTACATTTACA CACATCTTTATCAACACTTGTTATTGTCfC AAGTTGTGCAATCATCATCACTATCTAAA I I I I IAGTATCACCATGCAAGTGCCTGTG ACA I I I I IATTGCTTCCGAAAAAACCCAT AATGGTACTTCATTGCAGTTTTCATTTGC ACACATTAGCA AGTACCCTGATGACTAATAATGCTGAGCA TCTTTCCATGTGCTTATTGGCCATGGTAT ACCTTCTTTGGAGGAATATCTGTTCAAAC CCTTTGTTCA I I I I I AAATTGGTTTGTCTT TTTATTGTTGAGTTGTAAGGATTCTTTATG TATTCTAGATACAATTCCCTGATCAGATA CACAATTCATAAATATTTTCTCTGACTCTG TAGG I I I I I I I GC I I I I I IACAGTATCATT TGGAACCCTGTGTTTATCAGGAAGGGGT GTTGGGGTTTGTCAAAAGC I I I I I CTGTG TCTATTGAGATGATCATGTAGGG I I I I I I CTTTTACTAATATAGTGTATTATGTTGATT

Supplementary Table 3

SNP Chr Position 5' Flanking Seαuence SNP Base 3' Flanking Seαuence SEQ ID rs10786597 10 102281277 GTAAATGACATCACTAGTTGATGTTCAGA C/T TCTACCCACTGGCAACCACTAATTTACTT SEQ_0496

ATAATTGCACAACATCTGCATTCAACCAA TCTGTTTCTATGGATTTGCCTATTCAGAC TAGCAAACCCTGATCCAATTTAGGTCAAG AGTTTATATAAATGGATCATGCAATATGT AAACAGAGTTGATCTAATTTATTTA I I I I I GGCCTΠTGTGTCCATΠTCTTTCACTTA ATTAAGATATTATTCACATACCATAAATTC GAATAATGTΠTCAAAGTTTGTCTGTGTT ACCCTTTTAGGCCGGGTGCGGTGGCTCA GTAGCACATATCAGTACTTCATTCCTTTT CGCCTGTAATCCCAGCACTTTGGGAGGC TGGGCTGTATAATATTCCATTATATGAAT TGAGGTGGGAAGATTACTTGAGGTTAGG GTACAGTACAATATTTTATTTATACATTTA AGTTCAAGACCAGCCTGGCCAACACAGC TCAGTTAATGGACATTTGAGTTGTTTCTG AAAAACCCATCTCTACTAAAAATACAAAA CTTGTTTGGCTATTGTGAATAATGCTGCT ATAGCTGGGCATGGTGGTGTACACTTGT GTGAACATTCTTGTATAAG I I I I L GTCTG AATCCCAGCTACTCAGGAGGCTGAGGCA GATGTATGCTTTCTATTCTTTTGGTTATAT AGAGAATCACTTGAACACAGGAGATGGA GCCTAGGAGTAGAATTGCTGGGTCATAG GGTTGCAATGAGCCGAGATCACGCCACT GGTAACTCTGTGGTTTAACTTTTGAAGAA GCACTCCAGCCTGGGTGACAGGGTGAG CTGCCAAATTGTTTTTCAAAGCAGCTGTG ACTGTCTCAAAAACAAAAAACAAACAAAC ACATGTTACATCCCCATTAGCAGTGTGTG AAAAACAAAAACAAAAAAACCTTTTAAAG AGAGGGTTTCAGTTTCTCCACATCTTTAT TGTACAGTAGTTA I I I I IAGTACATTTACA CAACACTTGTTATTGTCTC I I I I IAGTATC AAGTTGTGCAATCATCATCACTATCTAAA ACCATGCAAGTGCCTGTGAATGGTACTT ACA I I I I I ATTGCTTCCGAAAAAACCCAT CATTGCAGTΠTCATTTGCAGTACCCTGA ACACATTAGCACGTTGCCCCTAC TGACTAATAATGCTGAGCATCTTTCCATG

TGCTTATTGGCCATGGTATACCTTCTTTG

GAGGAATATCTGTTCAAACCCTTTGTTCA I I I I I AAATTGGTTTGTC I I I I I ATTGTTG AGTTGTAAGGATTCTTTATGTATTCTAGA TACAATTCCCTGATCAGATACACAATTCA TAAATATTTTCTCTGACTCTGTAGG I I I I I TTGC I I I I I I ACAGTATCATTTGGAACCC TGTGTTTATCAGGAAGGGGTGTTGGGGT TΓGTCAAAAGC I I I I I CTGTGTCTATTGA GATGATCATGTAGGG I I I I I I CTTTTACT AATATAGTGTATTATGTTGATTATAAATAT

Supplementary Table 3

SNP Chr 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7091356 10 GTTATAAAAAGTAAACAAATATGGATATA C/G AGATGTTGAACTGACCTTGCATTCCTGGA SEQ 0497 TACTATTTAATATATAAATTTTGGGAAGGA ATAAATCCCACTTGGTCATAGTATATAAT CTACACAGCAACTTGCTGTCTTGTAAATG TCTTTTATATGGTGTTACACTGAGTTTGC ACATCACTAGTTGATGTTCAGAATAATTG TAGTATTCTGTTAGGA I I I I I GCATCTATA CACAACATCTGCATTCAACCAATAGCAAA TTCATAAGAAATATTGGTCTATAGTTTTCT CCCTGATCCAATTTAGGTCAAGAAACAGA TTCTTTC I I I I I I I I I I I I I I I GAGACGGA GTTGATCTAATTTATTTA I I I I I ATTAAGA GTATCGCTCTGTTGCCCAGGTTGGAGTG TATTATTCACATACCATAAATTCACCCTTT CAGTGGTGCAATCTCGGCTCACTGCAAG TAGGCCGGGTGCGGTGGCTCACGCCTG CTCCGCCTCCCAGGTTCACGCCATTCTC TAATCCCAGCACTTTGGGAGGCTGAGGT CTGCCTCAGCCTCCTGAGTAGCTGGGAC GGGAAGATTACTTGAGGTTAGGAGTTCA TACAGGTACCCGCCACCATGCCCGGCTA AGACCAGCCTGGCCAACACAGCAAAAAC A l I l I I I I GTA I I I I I AGTAGCGACAGGG CCATCTCTACTAAAAATACAAAAATAGCT TTTTACCGTTTTAGCCAGGATGGTCTCGG GGGCATGGTGGTGTACACTTGTAATCCC TCTCCTGACCTCGTGATTCACCCGCCGT AGCTACTCAGGAGGCTGAGGCAAGAGAA GGCCTCCCAAAGTGCTGGGATTCCAGAC TCACTTGAACACAGGAGATGGAGGTTGC ATGAGCCACTGCACCCAGACCAGTGTTA AATGAGCCGAGATCACGCCACTGCACTC A I I I I I I AAAAAATGTTTGGTAGGATTCAT CAGCCTGGGTGACAGGGTGAGACTGTCT CAGTAAATCTATCTGGTCTTGAGCTTTTC CAAAAACAAAAAACAAACAAACAAAAACA I I I I I C I I I I I C I I I I I I I I I I I I CCTGAGA AAAACAAAAAAACCTTTTAAAGTGTACAG TGGAATCTTGCTCTGTTGCCCAGGCTGG TAGTTA I I I I I AGTACATTTACAAAGTTGT AGTCAGTGGCACGATCTCAGCTCACTGC GCAATCATCATCACTATCTAAAACA I I I I I AACCTCCGCCTCCGGGATTCAAGCGATT ATTGCTTCCGAAAAAACCCATACACATTA CTCCTGCCTCAGCCTCCCAAGTAGCTGG GCACGTTGCCCCTACCTCTACCCACTGG GACTACAGGCGTGCACCACCATGCCTGG CAACCACTAATTTACTTTCTGTTTCTATG CTAA I I I I I GTA I I I I I GATAGCGATGGG GATTTGCCTATTCAGACAGTTTATATAAA GGTTTTACCATGTTGGCCAGGCTAGTCT TGGATCATGCAATATGTGGCCTTTTGTGT CGAACTCCTGACCTCAGGTGGTCCCCCC CCATTTTCTTTCACTTAGAATAATGTTTTC GACCTCGGCCTCCCAAAGTTCTGAGATT AAAGTTTGTCTGTGTTGTAGCACATATCA ACAGGCATGAGCCACTGTGCCCAGCCTT GTACTTCATTCC I I I I I GGGCTGTATAAT TTCTTTTCTTTTGAGACAAGGCCTAGCTC ATTCCATTATATGAATGTACAGTACAATAT TGTCTCAAAAGGCTGGAGTGCAGTGGTG TTTATTTATACATTTATCAGTTAATGGACA CAATCTCAGTTGACTGCAACCTCCACATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12354411 10 102284527 CAGCCTGAGCAACATGGCAAAACCCTTT A/G ATCTCATCTGAGGCTCCGTGTGTGTCCTT SEQ_0498

CTCTACAGAAGGAAAAAAAATTAGTCCG TCCCAAGTTCAGTGGTTGTTGCCAGAATT GCATGGTGGTGTGTGCCTTTAGTCCCAG CAGTTACTTGCATTTGTAGGATTAAGGTG CTACTTGGGAGGCTATGGTAGGAGGATT CCCACTTTCTTGTTGGCTGTCACCCAGG GCTTGAGCTGGGGAGGTGGAGGTTGCA AGCCTTTCTCAGCTCCTAGAGTCCACCT GTGAACCAAGATTGCATCACTGCACTCC GCCATTTCCTGCCATATGGCAGTTTGCTC AGCCTGGGTGACAGAGTGAGACCCTAGC CTTCAAGGTGAACAGGACAGCTGTGCTG TCAAAAAAAAAAAAAAAATTCAAACACTG TGGCTTCAAATCTCTTAGATTCTGTCTCT CAGATAAAATGAMGCCTTGATTGCCCC GACCTCTAGCCCTGATTTAAAGGGCTAG CTGCAGCCTCAAACACTTCCACAGAGGT AGTGATAAGATGAAGCCCACCAGGATAA AGCCCTATTATCGGTTTGGTGTAGCATG ATCACCTC I I I I I GACTGCCTTAAAGTTA GTTACTATGTAGCATAATTACATAGTTAA ATTGATTAGGGACTTTAATTACATCCTTG

GCCAGTGCATTCATTTCTATTACTGCATA TCATATAAGCTAACCTAATTACAGGAGTG

ACAAATTACTGTAAATTTAGCAGCCCAAA ATGCTCTATCATATTCACAGTCGTGTTTT

ACACCAATTTATΠTCTCACATATTCCATG CTTTTAAGGGGAGAAATGTATACAGGAT

AGTCCAGGTACTGGTTGGCTGAGTCCTC GTGTACACCGTAGGGTACAAATCTTGGG

AGCTCAGGGTCTTATCAGGCTGAAATCA ATACATCTTAGAATTGGGCCTCTCACAGC

AGGTGTTGGCTGGGTTAGC CAGCCATAAGAACT rs2295779 10 102286051 TGAAAGAGATGGGAGACTGGCAGGGCT A/G GGAGAAATTATTCTGAAGTTGAGAAGTAG SEQ_0499

CTAGACTAGGGCCTATGGGAAGATGGAG TTGGGATCATGGAGGCCAACCCACCGGC AGAAAGGCGAGGAGATACGGAACTTAGG TCCTTGGCATTACTTCATTTGGTG I I I I I GGTTCGTGCTGATTAAC CACCTGTTGTTTTC rs 10883509 10 102286451 TCTGTGTACAGTGCCAGCACCCACAAGT CfT A I N U CTTTCCTATACTTGTTTGAAGGTG SEQ_0500

TCTTGTACTATGATGAGAAGAAGATGGC TGGCAGAATTGGGTCAATTAGAGATTGG CAATTTCCAGAACTTTAAGCCGAGGTCCA CCTCTCCCATCTCTGGATTCCAGTTGAAG ACAGGGAAGAAATGAAATTTCATGAGTTC GAGTAGTCTGGTCTTCCAGCCTTTAAGG GTTGAGAAACTGCAGGATATACAGCAGC GGTTTGAGTTCTTAGTGGTTCTTGGTGCT GAGGAGGGGAAGAGAGGTAAATTCCGAA ACAGCCAGCTAGTTCTGTAGCTTGAGGG AGCTTAATTTTCTGTTGGATTTAGGACAC ATGAGGGAATGATTAAACTTGAGCTATG T

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10883510 10 102287008 TTAAACTTGAGCTATGAATCTCTGGGTTC C/T CGATTTTCAAGAGAAGTTCAAAATCAGGA SEQ_0501

CCATCTTCTTCCTCATAAAGAGTTAGTTG I I I I I ATTTAAAATCTTTTGACTTTAAATG

CCTAGAAGGGTCAGGCAGGTGAATGGAA GAGCAACTAAATCAGATTTAAAGAAAAAA

GGAGTAATATCGTCTGTGTGAAATCAGT AGTTGCAGGGGGCCAAACAAAAATGTTT

GATGAGGCTGAAGGCATAAGCCTTGTTC GTCACTGGATTTAGCTCTGAAAATGCCTG

AAAGTGAGAAGCCAAGGCCGGCGGGGG TTTGTAGCCATTGTCCTTAAGTATTGTGA

TGGCTCATGCCTGTAATCCCAGCACTTT TGACTGAGGATAGTTCAACCTGAAAAGTT

GGGAGGCCGAGGTGGGAGGATTGCTTG GTATAGTTTGTTGTGATTCTGCAGTAAAG

AGTCCAGGAGTTCAAGACCAGCCTGGGA AAGGTTAGGATTCTCTAGCTTAGGGAAG

AACGTGGTGAGAGCTAGTCTCTGCAAAA ATCAGATTAAATTTG I I I I I CCTATCACAA

TTAAAAACTAAAACAAAAAACCATGGTGA CAGCAACACAAGACACACAA

GAGGTCATTACTTGACTCTGCTTGCTTCA

GTTTTGGAGTGCAGTTCTAGGGTTGGGA

GATATT rs11190602 10 102287246 GCATAAGCCTTGTTCAAAGTGAGAAGCC C/T AGGATTCTCTAGCTTAGGGAAGATCAGA SEQ_0502

AAGGCCGGCGGGGGTGGCTCATGCCTG TTAAATTTG I I I I I CCTATCACAACAGCAA

TAATCCCAGCACTTTGGGAGGCCGAGGT CACAAGACACACAAGACAGTGATTCTTC

GGGAGGATTGCTTGAGTCCAGGAGTTCA CTCTCTGCTTTTATTCCTGCTTATGAGGA

AGACCAGCCTGGGAAACGTGGTGAGAG CAGCCTCTTATGTAGGTCCGAGACAGTA

CTAGTCTCTGCAAAATTAAAAACTAAAAC TTCAGTCCCACACTATAACACTGCCTCTG _W

AAAAAACCATGGTGAGAGGTCATTACTTG GGGAATTGCTTTCGCTCAGTACTTCACG S

ACTCTGCTTGCTTCAGTTTTGGAGTGCAG

TTCTAGGGTTGGGAGATATTCCGATTTTC

AAGAGAAGTTCAAAATCAGGA I I I I l ATT

TAAAATCTTTTGACTTTAAATGGAGCAAC

TAAATCAGATTTAAAGAAAAAAAGTTGCA

GGGGGCCAAACAAAAATGTTTGTCACTG

GATTTAGCTCTGAAAATGCCTGTTTGTAG

CCATTGTCCTTAAGTATTGTGATGACTGA

GGATAGTTCAACCTGAAAAGTTGTATAGT

TTGTTGTGATTCTGCAGTAAAGAAGGT rs7084810 10 102287536 TCTGCTTTTATTCCTGCTTATGAGGACAG A/G GTCTGTGGCTAAGTGAATGGATTTGAAAT SEQ_0503

CCTCTTATGTAGGTCCGAGACAGTATTCA ATC I I I I I I I CTTCTTCTTAACACTTAGCA

GTCCCACACTATAACACTGCCTCTGGGG GTTGTCATAATGATGGGA I I I I I GACCAG

AATTGCTTTCGCTCAGTACTTCACGGTGA AAGAGTTTCCAAGATATGAACTGTGGTC

ATTACCCTCTCGCATTTGGTGTCCAACCC GATCTGTCCATGATGTCTTAATATATTGG

TGGGTTTCTCTCTAGTCTCTTGCTTCACT TTCAGTTATCTCATGCATTAATTTTCTAAA

CACTCCTGTTCCTGACTCCTTATCAGC ATTTAACACAGTGTGTGTGTGCACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4919471 10 102289229 TGTC I I I I I I I I AGGTTTGCACACTTATTA A/G CTAGGCTTCAAGCCAGAGCTCGGGCTAG

AATGTCTCTTGTGGGCTTGTTCAAGTGTG AAACAACAGAGGCTTATTTCTCACTTACT

TCTGGGTTTTCATATCTCTTAAGTAACTTA ACATGTTGATCATGGGTAATGTCATATTG

TGACCTTCCTCAGGTATGTTAGGAGCCT TTCTTTACATCATCTTACTTGCTCTGGCA

GAGGCCTTTACCTAATAAGCTATCTTCCT CCCAGATTGCCCCAGCAGCTACTATCTA

TACTTTAGCTGTAGAAGGCTGCAACAGG GAACTTTGGAGTTGCTGTGGCAGAAGGA

ATAGGTGGCTGAATCAGTTAAGATAA AAGAGATGTGGTAGTGGTAACTTGTTCTT

AAATTACAGTTGGAAACAACACAAGTCGC

TTCTGTGGACATTTCCTTGGCCAGAGCA

GCGTAAATAAGCAAGCCTGGCTTCAAGG

GGATGTGAAAGAAAACTCGCACACTGAG

GGAACCAGCTCTTGGTGAACAGTAATAC

AATTTACCACAGTGGTCATCAAGGGCCA

ACGGAGA rs 1088351 1 10 102289397 GGTTTGCACACTTATTAAATGTCTCTTGT A/G GGAAAGAGATGTGGTAGTGGTAACTTGT SEQ_0505

GGGCTTGTTCAAGTGTGTCTGGGTTTTC TCTTAAATTACAGTTGGAAACAACACAAG

ATATCTCTTAAGTAACTTATGACCTTCCT TCGCTTCTGTGGACATTTCCTTGGCCAG

CAGGTATGTTAGGAGCCTGAGGCCTTTA AGCAGCGTAAATAAGCAAGCCTGGCTTC

CCTAATAAGCTATCTTCCTTACTTTAGCT AAGGGGATGTGAAAGAAAACTCGCACAC

GTAGAAGGCTGCAACAGGATAGGTGGCT TGAGGGAACCAGCTCTTGGTGAACAGTA _W

GAATCAGTTAAGATAAACTAGGCTTCAAG ATACAATTTACCACAGTGGTCATCAAGGG ^

CCAGAGCTCGGGCTAGAAACAACAGAGG CCAACGGAGATGTCTCAGGCTCTGCGAG

CTTATTTCTCACTTACTACATGTTGATCAT TCTCTGGAGTGAGACTGATTCATCATTCT

GGGTAATGTCATATTGTTCTTTACATCAT AGGGTCTGTGGATAGGCTTCTAGGAGTC

CTTACTTGCTCTGGCACCCAGATTGCCC TGAAATTGTGTGAAAGTTCTGGGTGTATG

CAGCAGCTACTATCTAGAACTTTGGAGTT TGCATTT

GCTGTGGCAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7099965 10 102291155 GGGGCAGCTTACCTCTAACCTGCTGCTC A/G AAAGAAATGAAACATGATAATGTCTTGTA SEQJD506

ATTGGCATGGAAGGTAAGAAATCTTTCAA AATAGTTGTGAAGTTGTGAAGATTAAATG AAGCAGCATGGCTTGGAGTCATATGAAC AAATAATGTATGTCGAGTCTG I I I I I I I I I CTGATTTCTAATCCTGTCTTCACCGCTTA GTTGTTGTTGTTTTG I I I I I I I GAGACAG TTAGCTCCATGACTTTGAACAAGCCACTT AGTCTCACTCTGTTGCCTAGGCTGGAGT CACTTTCTTAAGCCTCAGCCTACTCAGCT GCAGTTGTGTGGTCTCGGCTCACTGCAA CTAAAAGAAACATAATAGGGGCTGGATG CCTCCGCCTCCCGTGTTCAAGTGATTCT CCGTGGCTCACGCCTGTAATCCCAGCAG CCTGCTTTAGCTCCCAAGTAGCTGACAC TTTGGGAGGCCAAGGTGGGTGGATGATG TACAGGCGTGTGCCACCATACCCGGCTT AGGTCAGGAGATGGAGACCATCCCGGC ATGTCGAGTCTTTAAGCTAGTTTCGTGTA CAACATCATGAAACCCCGTCTCTACTAAA TTCTAAAAAGTTCCCTTTTCCCTTCCTCA ATACAAAGAAAACAAATCAGCTGGGCAT GCTGTTATGTGAGTGTGTATACTGAGATA GGTGGTGCGTGCCTGTAGTCCCAGCTAC TTAGGGACCTCTCTGAAATACAGACATGT TCGGGAGGCTGAGAGAGGGGAATTGCTT GATGCTTAATGTCAGGGATACGTTCTGA GAACCCAGGCGGTGGAGGTTGCAGTGA GAAATGTGTTGTTAGGTGACTTCATCATT GCCAAGATCACGCCACTGCACTCCAGCC GTGCAAACACCATAGAGTATAGTTACACA TGGCGACAGAGCAAGACTCTGTCTCAAA AACCTAGATTGTGTAGCCTTCTATATGCC AGAAAGAAAAAGAAACATAATAGGGCCA TAGGCTATATGGTGTAGCCTCTGACTAAA GGCATGGTAGCTCATATTTGTAATCCCAG CCATGTACTACATGGTGTTAGCATATTAC CACTTTGGGAGGCCAAGGCAGGAGGATT TGTGCTGMTATTATAGTCAATTCTAACA GCTTGAAGCCAGAAGTTTGAGGCTACAG CAATGGTAAGTATTTGTGTATCTAAACAT TGAACTATGATTGCACCACTGCACTGCA ACCTAAATATAGAAAAGGTATAGTAAAAG GCCTGGGCAACAGAGTGAGATCCTATTG TACGGTATCAGATACTGCAGGAAAAAGG CTTAAAAAAGGAAAAATG T rs11190604 10 102292447 TCGTAGATGCAATCTGTTGTCGACTAAAA A/G ATTCAAAAGGTGTAAATAGGTACATAGTG SEQ_0507

TGTCATCATGTGGCACATGACTGTACCA ATAACTACCCCTGTCTCTTAGCCTCCCAA CTTTTCTCTACTAGATCTGTCTATATTCAG TTTCCTCCCTGGAGGTACTGCATATTATT ACAAI I I I I GTCCCTGTGAAAGAGGAGAA AGTTGCTTGTGTTTTCTGCTAGAGAAATT ACTTAT I I I I I IAGTGTAAATTCAACTTTA TATGCATACACTAATAAATATGTGAATGT TTG I I I T l ATTTATTTATTTA I I I I I GAGAC G I I I I I I I I I I I I I I I I I I I I I I I C I I I I GA AGAGTCTCGCTCTGTCGCCCAGGCTGGA ATGAAAGGAGAGGCCCTTAAACTCCACT GTGCAGTGGCGCGATCTCGGCTCACTAC CAGGAGAATGAGAGC I I I I IATGA AAGCTCCGCCTCCCAGGTTCACGCCATT CTCCCACCTCAGCCTCCCAAGTAGCTGG GACTACGGGCGCCCGCCACCACACCTG GCTAAT I I I I I I l GTACTTTTAGTAGAGAT GGGGTTTCACCGTGTTAGCCAGGATGGT CTCGATATCCTGACCTCATGATCCACCTG CCCCGGCCTCCCAAAGTGCTGGGATTAC AGGCGTGAGCCACCGCGCCTGGCAAATT CAACTTTATCTTTTAAATAGATAATACATT CATGGAGTTCG

Supplementary Table 3

SNP Chr Position 5' Flanking Seoueπce SNP Base 3' Flanking Sequence SEQ ID rs12219158 10 102292913 CAGTAGCTCAATGCCAGGCCCATGGTAG CfT ACCACCTGCCTC I I I I I I I G I I I l I GTTTT SEQ_0508

GTACTTAGTAAATGGTGAATAACCTGGGT TG I I I I I I ATTGAGACAGTGTCTCACTCT ~

TGAACAAGGAAACAGAGAAGTTATTTATT GTCACCCATGCTGGTGTGCAGTGGCATG

GTCATTCACCACTTAGCTCCTTGGTTTCT ATCAGGGCTCACTGCAGCCTTGACCTCC

TCTTGTTTGATTGTCTGTTCTTCAGATTTG CAGTCTCAAACGAfCCTCCCACCTCACC

GATCCTTTGCTGCTGGTACTAATAAAGAT CTTCCAAGTAGCTAGGACTACAGGCGTA

TTCCGGCCATGTGGCTTGTGAATTGA AGCCACCATGCTTGGCTAA I I I I I AAAGT

A I I I I I CTGTAGAGATGGGGGTCTCCCTA

TGTTGCCCGGACTGGTCTCGAACTCCTG

GCCCCCTCTCACCTTGGCCCCCTAAGTG

ATCCTCTCACCTTGGCCCCCTAAAGTGTT

GGGATTACAGACGTGAGCCACTGTGGCT

AGTCTTACCTGCCCCTTTGAAACCAACTC

TTGGTTGACCTGCCAAGAAAGAGCCAGT

TCTGGTTTACTTGACTC I I I I I I I I GAGAC

AGAGTCTCGCTCTGTCGCCCAGACTGGA

GTGCAATGGCGTGATCTCAGCTCACTGC

AAGCTCTGCCTTCCG rs7088827 10 102293855 TCCTGTGGTAGGGTGCATGGAAGTGGAT C/G ACGTGGTCCTAGTTAGAAAGGAGTAGAT SEQJD509

CCCTCAGGTAGAGATGAGAGAGCAAGTC GGAACATACACTAGGGCACAACTAATTC _w

TGCTTTGAGGATGCATGTGGACTCTCAT AAGGTGGCATTTAAAATAATGTGCCATAT £2

CACTTAAGAAAGCATCTGTCTTGGCATAC TTAAATTACACAGCACTCTCTTCAGTCAT

CCAGACAGAGCTGGGGAAGATTGTCTAA CTGATATTCTTTCCTCCAATGAAAATCAC

ATTCCATGCCCTGCAAAAGTGTGTGTTCA TTGCACCAGTGAGCCCCAATGTTGCTTTA

ACTCATGGACTGTGCAAAGGCCAAACAA AGAAGTGTTGTCTTGGCTAGATGTGGTG

CA GCTCACGCCTGTAATGCTAACACTTTGG

GAGGCTGAGGTGGACAGGTCACTTGAG

CCCAGAAGTTGGAGACCAGCCTGGGCAA

CGTGGTGAAACCCCATCTCTTAAAAAAAC

AAGTATTGCATTCGTTAGGTG rs2295780 10 102295955 AGTGGTTGGCCCTGGTGATGTTCTTTAC A/G TAGTGGCGGGAATGATAGCCCTGTCTCT SEQ_0510

ATCCCAATGTACTGGTGAGAAGGGGGCT AGGACAGGATGACGGTTCTTCAAGTCCA

AGGGCTGGGGGC I I I I I GGGAGCTTTCT AAGAGATTCCGGAGGCTTGAGCCTAGAA

TTTCCATTCCCTGGAAAGCCTTGTCTGTG AAACTGTTCTTGGCTCTTTGGTATTTCGA

TCGCTTCTGAGTTATGGCATGATTGGTTT GACTGAACACCAGTACCTCTAACCCCCA

TATGTGGTCTATAGGAAGGTTGGCATATC AGTGTGTG M I I I I i CACAGGATGAGTGT

CAGACATGAGCGTACTGAACCTGTGGGG AAAGATATTGTCTTCACTATTTTCCGTAA

G C

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7073586 10 102297661 TAGCATCAGCCCCAGTTGCAGATGATCA A/G CTATGTCCCAGAATACTGGGTTGACCTTC SEQ_0511

I I I I I I GAGGATATGGAGGCAGTTAACAT AGGAAGATAGGTGATTAGAGGATTCACA

TCTGGAGAAACATATAGACACTCTTGGGT AGATTGTATGAAAACATTGTCTCTGTCCT

GTTCGGGGATTATTAGCTTCTCTGACCAT TGGCTGGACATCTGATGTCTCCAGACAC

GTCTGTCCGTTTGGGGCAGATTACGGTA ACCCTGTCCAATTCCAGGGCCAGGGAAC

AGAGACGGTGTTGTGCGAGAGAAGAATA AGCCAGTTCTGATTGGCTCCTCATGTTTC

ATAGTACAAGATGGACCCCTGAGGGAAA TTTACAGGTGGGGCCCTTGTTGAACACA

G A rs10883512 10 102298506 CCTCAGTGCCTCAGCCTGAGAGAGAGAT NG TATAGCCTTCCTGTGAGAGAGGATTAGAT SEQ_0512

GAGATGCTCTTGGACTCCCCACTGCATC AGGGTTCCAACTGGGCCTACAAGCTCAA

TGGGCTGCAGGGCCAGAGCTAGTCTGA GCCATACATAAAAGGACCTTGGGACATA

CCATTAGGTCAGTCTGCCTCCTGACAGT AGAACCAATGATTGTGCATAAGTTCTAAA

TTTTGCGTAGTCAAGCTCTAGGCGGTAT TTAGAGACACATATAGTTTCTCTCTTTCA

GGGAATGGCTACCGGGACTCTAATGGG GCACCAGCTCTTGCCCCTATGCTGGGTA

GTGAAAGAGAGGGGAGGCTTGCCTTTGA CCAAGGGAGTTCTCCTAGCTGTGGCTTC

GAGCCT T rs11816840 10 102299210 GCCCGAGGCTAACTGGCTAGAGCCTCCA C/G TTGTAATGTGCCACAACACCCTCAATAGT SEQ_0513

GGCCCTATGATGCTCCCTGCCCAGGCCA CAGGGCAACTGGTGGAGCATGGAAGTC

TATCCTTTATTCCTGCTGAGCTTCCTGGC GAATTTCCTTTTCTGTTAGGAGCTACTCC

TGAATAGATGAAATGGGGTCAAGCCCAG TGGGAACCCCTCTCAGGGCTGCAGCTTA W

GCAGCTCATTCACTACCTGTGATCCACCT CAGGTGGGCAGCTGTGATTGCACAACTT C.

CAGGGCACGGGCAAACACATAGGCTTGC GAAGGGCCATCATTCACATCTATTCAGTG

GTCTTAAAGCCAGCTCCTCTGCCAGACC GGAGTGGGGTCCCTGGGATTGGGCAGT

CC GTGGTGGCCCTGTGTCTCCTCACCTCTG

CTCCTGTCTTCATCACCTTCTCTCTGGAA GGGAAGAGGAGTTGGAAGGTCTCTGGTT TTC I I I I C I I I I I I I I I I I I I I I GCCAAAG GTTTACTTCCAGC rs11292 10 102303597 CCCTCAACTCAATATGGTTTATCTAAGGT C/T TTCAGTTATTCCAACAACCCTGAGGTAGA SEQ_0514

GTTTCTCG I I I I I CCCTATGCTTTTCTTGA TATTTTCAACATGCCTCCCTCCACCCATG

GAGAGAAAGAACCACTGGAAATCTGTTT TTATTATAGTTGAGGAAACTGAGGCTCAG

AGAGATCACTGAAACCAAGTTTCTGAATA AGAGGTTAAGTAAATCAACCAAGGTCAAA

AATCACATAATAAATATAACCACCACCAC CCCAGCTGGTAAGTAGTGAAGCTAGAAA

CACAGCCATTTATTAAGTGCTTGCCAGG TTCAAACCAACTATATGTGACTCCAAAAT

CACTGTGCTAAAGCTTTACAAACATTG CCATGCCTTTAAACACTATCCTAGATTGT

TTACCATTGAAAGTTAAAGGACATATGCT

CCTTCCCAAAATATGAGAATAGATTTTCA

GTGGGAAAGCAGGGGGGAGCCCATATG

TAAATTCTTTCATCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11190613 10 102303987 TGAGTTGAGGGTAGACAGAAGAGTCTAG C/T ACCTGGAGAAGCTGTTGTCTCCTCACAC SEQ_0515

TACCTAAACTCACCCTAGAGGAAGAGAA CATGAAATGTAATAGCAGTCAAATCAGGC ACAGGAAGTGTCTTATGCCTCTTCTGCCT CCCTCTTGATTCAATTTTAGTCCATGCCT GGGCAGCCAGACTTTACTGCTGTACTAC TTCCATGTATTTAAATTATATAAGTGTTGG CAGCCCAGGGCCTTGGGTGAGAAGGTTT CCAGGTGTGGTGGCTCACACCTGTAATC CAGGTCTGAGCTCCCCTTGCACTGTGTG CCAGCACTTCGGGAGGCTGAGGCAGGA AGAGGCCGTGGAGCCGAATGAGTCCTTA GGATCACTTGAGCCCAGGAGTTCGAACC TTA AACCTTGGGCAGCATAGTGAGACCCCTT CTCTTAATAA I I I I I I I I GAAAATAA I I I I I TAAAAATTACAAATATGGACCAGACACCT GGGAGGATTACCTCACGCCTGTAATCCC AGCACTTTGGGAGGCTGAGGTGGGTGG ATCACCTGAGGTCAGGAGTTTGAGACTA TCCTGGCCAACATGGTGAAACCCTGTCT CTACTAAAAATACAAAAATTAGCCAGATG TGGTGGTGGGTACCTGTAATCCCAGCTA CTCGGGAGGCTGAGACAGGAGAATCACT TGAACCTGGGAGGCGGA

TS4919472 10 102305854 CCGTTTACTTAAAACCTATTCACTTGGTC AH^" CTAAGTTCCTGTTTCTAGTCTCAGGGCAT SEQ_0516

ATTGAGGTCAGAACTATCAGGAAAGCTG ATCTAGTTGTCAGCTCCTGAGCAGAGCA TGCTCCTTAACCCATCATCTAAGCTAAGC GAGGTATAAGTGTCAACTCATGCTTGTGT TTGGGCCAGG I I I I I ATTACCTCTTGAAT TACCAGTTCCTACCCCTGTCAGTAACCTC ATATATAGTGCAATATAGTGTAGTGGTTG TGATGCTTACAAGGATACTATCACCTATG AGAGTGGAGTCTGCATACCTGGATCTGC CCATCAGTGGGGAATGACCTTCCAAAAA CATTCTGCATGACTTTGGGCAAATGGAC ^• TATTTTTAACAATACTAAAAATACCTGA AAACTGCCCGAAACTTGACTTGTTTATAT GTATGGGGAAGACATCATTTACATTGTCA GGGTAAGGCTTAGCAGAATGACCGGTCC ATAGCAAGGGCTCAGTCTTTCTGTGTCTC TCAGTCTTTACCTCTCTTCCCCATCTAGC TTTCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489034 10 102309182 TACTTAAGGAAATCAAATACATTAATCATA CfT TGAGACAGGGCATTGCTTTTCGACGCAG SEQ_0517

TAAATGCCATTTAAGTGTTTAAAGGAGTT GCTGGAGTGCAGTGGGGCAAGCATGGC

TAGTTAAATGTAAGTTGGATCAAACATTA TCACTGCAGCCTCAACCTCCTGGACTCA

AAC I I I I I I GTTTTATAAGCAAAATAATAA AGTGATCCTCCTGCCTCAGCCTCCCATG

GATTTGTTAGCAGAACTTAAAAGCTTAGA TAGCTGGGATCACAGGCACATGCCACCA

AAAGAGAGGATTTTGGATATGTAACTTTG CACCTGGCTAA I I I I I I A I I I I I I GTAGAG

AAGAGGTGAATAGTTTGCTCTTTT ACAGGGGCCTCACTTCATTGCCCAGGCG

GATCTCGAACACCTGGGCTCAAGCAGTC

CTGCCTCAGCCTCCCAAAGTTCTGGGAT

TACAGGCATAAGCCACTGTGCCTGGCCT

TGAATATAI I I I I I AACCAAAGTAATTTAT

GAATATAAATTGTTTCTATATAACCCAAA

GTCACTCTCATTGACATTAAGAAACTCAG

AGAGTGGGTTC rs2489037 10 102309908 GTGGGTTCTAAATGTAATATTACCACACA CfT TGTCTGGCCCACATAGATATTTGAGGGT SEQ_0518

CCCAAGTCACTTAGCCTCTACAAGTACCA ATGGCCCTGAACTTGAGGCACTCTGGAG

CGTAACTAGCAGCCGTTAAAAGATGGCC TTGCTAACAACTGATGCTGGGCAGCCTA

ACCGCTAGTCCAGTCGGCCACAGACATG GAATAAGGGCTCAGGAAAAGTGTAGGCC

GTTTTGTTTGGCCAATACAAG I I I I I GAA CTACCTCTCTCTGTTCACATCATTCCCCC

AGTTTTAAAAAATTGACAACATTAAAGAT CTCCAGCCA

CAGAAACTTGACCTAAAAAGATTTCTCTC -i

TTTGGAAAATCAGATCTGGCAGTAATGAA ATCGCCTTTCCCATGTGACAGCAGTTGG CTGGAGCTGAAGAGCAACTGCCCCCTTG GCTGTGTTCCTTTCAGTTTGTCAATCTCC ACTCTTCACTGTTGTACCCTAGATCTCAC TCACGTGAC rs2495759 10 102310353 CTCTGCCTATAAATGTGCAGTGGCCTCC C/T AGTGATGGTGGAGATAGAAGCAGAAGAT SEQ_0519

CTTGCCTAAAAAGCTCTCTACTAGCTGCC TCACAACCACATCACAAAGATCAGATATG

CCCTTAAACTGTGGTTGGCTTCTGCCTCT GTGGCTGCATAAAGCAGAGAGCCCAGGA

GTCCTTCTTTTGAAAATCCAAACACTTCC CCCCTCACAGACCAAAGTCAGGCTGCGG

AAACTCACCTTTCATGTCTCCTAAGCCTT TCAAACTAGGCAGGTGACCAGAATGTTC

TAGCAATCTGGGCTGCCAATCTCTCAGC AAAAGGACTGAGACATGAGGTCAGAGCC

TGAGCAACCATATTGCCCAAGCAGTGGA TAGGCAAAGTGCCTGGTCACAGACAAGA

GCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs2495753 10 102315630 TCCTTAGCTTCTGGCTGGAGGCTGTMG A/G CCACTTCTCAGAAGGGACTGπATCAAA SEQ_0520

GAGTGATGATGATGAGGAGGAGAAGGA GCAACAGAAAAAAAGCCTTTCGAAAACC

GGAGGAGGAGGAGGATGCTGGCAATGG AACTGTCACCAACTGGCTGTGTGACCTT

CAGCACCCTCTTAAGCAGCACTTTCTATG GGCCAAGTTACTTCCCTTCTCTGAACCTC

TACTAGACACTG I I I I I I I I I I CAAATCTT AATTTCCTAATTTGTAAAATGATAAAACAG

CTACATATATTCATTCATTATCATTACAAC TACCTAGTTCGCGGTGGTTTAGAAAGGA

CCTATGAGATAGTGTTACTATTATTCCTG CTCGTGAATATAGAACACTCCTTGGCATG

TTTTTCAGATGAGAAAATTGAGGGAGAAA AAGCAAGCACTCCCTTTCTGTACCTCCTC

TTAAGTAACTTGCCCAAGGTCACCTACCT CTGTCCTTCCCTCCACTCATAGCCTACCT

AGTAAGTAGCTGATGAAAAGGCATAGCA CAGATACTT

GAAAGTCAGACTTTGGA

ΓS2495751 10 102317250 GCCTCAAATTGGGGGTCAAGTGTGTGTG C/T TCTCATGTACACACCCTCTTCAACTTGCC SEQ_0521

TTGCGGGGAGGTGGAAGTCAGAGAATAG TCCTGAACCACGGCTCGGTCCACTCTCC

AGCCTGGAGAAATCCACTACTTTGGACC TTGAACTCCCAAATTCCTCCCGCCCCTG

TGAGGTTGGCTGAGGTTGGGGGTGGTTC AGTCATCTTCACCCTCAGCAGCTCCACT

CCTGTGAACCCTAGTTCAGGGAAACGCT GTTCCTGGCTTCCACCCTGCTACTCTGC

CTTCTCCTGCTCCCTTCCCCTCTGCAGG CAGCTCCTAGGCCTGTTCCCTGCAGCCG

CCTCAGTGTTTCCGCACCCCACCACCGC GCAGCGCTGGCAATGCCCTCTCCTAGTT

CCCG CTC rs2495750 10 102317698 AAGGAGCAATAAGAATTGAATGAGCCCA C/T AGCAGTGGCAGATGATGACTGGGGGAA SEQ_0522

ATTGGAGGAGGATTCCTAGAGGAGAGGA GTGGGAGATGCAGGGTGGCCCACACAC -J

GTTTTCAACATCCCATGCAGATTCCTAAC TGTTTGAAAGCCCATATGCACTGAGGAT

TCCGGTGACAGACTCAAAGAGACCAGGG GGCAAATAGGAAAAACTCTAAAGTCAGG

AGCTGGTGGGGGAGGGAGTCGGGGCGC TCACCTTACGGGAGCAGAGCTTTCTCCT

CACTTCTCAGAAGGGACTGTGATCAAAG AGGGAAGGGAATGCTGAGGGCAGAGGA

CAACAGCCAAGAAAAGCCTAGTTGGGCC GGCAGGGAATCCCCTGGAGCCAGATGA

TGAA GTGAGGAC rs2489039 10 102318026 CATGGGATGTTGAAAACTCCTCTCCTCTA AfT AGAGCTCACCTAGTCCAGGAGTTTCCAA SEQ_0523

GGAATCCTCCTCCAATTGGGCTCATTCAA GGATATTTTTAACCTTAGAACCTTCAATT

TTCTTATTGCTCCTTTCCTCGGTTGAGTC CTGAATGTACACACACACACACACACAC

TGCAGATATGGAGTCCACTTAGATAACTT ACACACACACACACACACACACATACAC

TGCAGATAAAAAGCAGCTCGTGCTCTGC ACAGAGAGAGAGAGAGAGAGAGAGAGA

TATCTGACTGGGAACCA I I I I I GCCTCTA GAGAAAAGCAGAAATACGTTGGCTGAAA

TTGCATTGTAATATTCTGTAAGGGAAC TTTACCCTTGCTCTAACCTTTACCCATAG

CAG

JS2495747 10 102318237 AAACACAAATTACATTTTTAAAAAACACTA A/G GTGTCTAGGGCTGCTATGGGTAAAGGTT SEQ_0524

GAGGGAGAGCTTGGCTGGATGTTAATAA AGAGCAAGGGTAAATTTCAGCCAACGTA

GTCCTAGAATGCTAGAATTGGGAATTGG TTTCTGCTTTTCTCTCTCTCTCTCTCTCTC

GGGAATCCTGAGTTTTTGCTCCTGCTGT TCTCTCTCTGTGTGTATGTGTGTGTGTGT

GTGACCTTGGGAGAGTCCCTTCACTTCT GTGTGTGTGTGTGTGTGTGTGTGTGTGT

CTGGGCCTTTCTCATCTGTAAGTGAAGAA GTACATTCAGAATTGAAGGTTCTAAGGTT

ATTGGGCTTTCAGAATGTGCTCCATGGA AAAAATATCCTTGGAAACTCCTGGACTA

GCTCTAAGGGTTCTCAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2495745 10 102319065 AATCACTCATGATGTTCGTTGCCCATAAT A/G CGACTAGTCAGAGAAGCAGACCAAAAGA SEQJD525

GATAATTTGACAGTATCTGCTTCATAGCG AGGAGACGGAATGAAAGGAACCCACCTC

GCACTTAATAACTTAATATTTATTGAATGA CGTCAGGGTTGGGGACAGGGCATTCAGT

TACAGTGGCAATACATTCACAGACTAAGA TACCCTTTGCAACTGGAGACATC I I I I I G

TTCACACATATGTACCTTACAGCTGAAAT AAACACAAATCTAATCCTAGAATAAAGCC

AGATACAGCACAAAAAGTGGAAACAAGC CCAGCACTACTTAACAGCCTGCGCAGCC

CCTGCTAAGAATGTCCCAAGCAGAAC CATCTGGTATGTGGCCCCTGCCTGCCCA

TC rs2495744 10 102319399 AGCTCCGGATTTACAGCAGGAGATGGGG A/G TAATGACACCTACAACAGACTTACACCAA SEQ_0526

TCTCCGGTGCCACCCACAGACGCTTCAC CAACCATACAAGAACACAGCTACCCATG

ACCCACCAAGTGTCACCCGGTCAGGGCA TGGTCAGTCACTTAGAGCACATGATTAAC

CACATGCTGACAGTCGTACATTCACACT ACATTCACACACGACACAATTCACCAACG

GCACAGTAACACACACAACCACACATCA TTGCACACACAGACACACAATCACTCATG

CCTCAGCCACGTGATGCTGTCATATCAA ATGTTCGTTGCCCATAATGATAATTTGAC

GTCACACACAAAACCCACTATGACAGTC AGTATCTGCTTCATAGCGGCACTTAAT

ACAC rs9420797 10 102321137 AACATGAGTGTGACTGAATGTGCCTTTGT C/T GACTCTGCTCTTCCTTCCCCG I I I I I I CT SEQ_0527

CTCAGTGTTGTGAGTGTGATGGCATGTG AATTCAGTTCCTCTTATTACAAAAATAAAA

TGGTGCCTTGGTGTGGCTGTGTGTGGCT AATAAAGCGCTGCCCCTTTCCAGTGGCT

GTGTGTGACTGTGTGTGACAGCGTGTGT GGCCCTACGGAGCCCCCGCCTCGGGAC _W

GTGCGTGTGTGTGTTTGGTGAGCGGCTC CAGCCTCGTTTCACTCCATTTCGGAGAAA ^

TGCTGCCTTAAGCACCTTTCGAATACATT ACGGGAAGTCGGTAATTTTAAAAAATATT

GGCCACAGCTCATTGAATCCTTTAACAAT TTCTACTTTATTTGGGATTTAATGTTCT

C rs2489040 10 102321288 AGCACCTTTCGAATACATTGGCCACAGC A/G TCGGTAATTTTAAAAAATATTTTCTACTTT SEQ_0528

TCATTGAATCCTTTAACAATCTGACTCTG ATTTGGGATTTAATGTTCTTACAGAATCC

CTCTTCCTTCCCCG I I I I I I CTAATTCAGT TGCTGCTTCCCTCTGCCCCCCGACCCAT

TCCTCTTATTACAAAAATAAAAAATAAAGC CCACCCCCAGCCCCGCATGCAAGAGGC

GCTGCCCCTTTCCAGTGGCTGGCCCTAC GTAATGGCCCGTTCAGCATATTAGGGGA

GGAGCCCCCGCCTCGGGACCAGCCTCG GCTGAGCGCGCGTGTGTGTGCACACTTG

TTTCACTCCATTTCGGAGAAAACGGGAA GATAAAAACACACAGAGACCCGCAGCAG

AC rs2495741 10 102321785 TTGGCAAGGCTGGTCTCACACTCCTGGT C/T GACTCATTCCCCCGGACTACTCAATTCAC SEQ_0529

CTCAGGTGATCCGCCCTCCTTGGCCTCC ATTCCTTTACAGCATAGAAGTTGCTTCCA

CAAAGTGCTGGGATTACAGGTGTGAGCC AACTGTCTCTCACCGTGAACATGTCTCTC

ACTGCACCCAGCCCCACGTCTTCTCGAC TCCTTCCTCCTATCTCTGACCACCTGCCT

TCCCTGCATGACCTTGAGTAATCATTTCT CCTTCATGTCTCCAGAGGTTCTCCTCTGA

TGACCATACAGTGTTCCCTTGTACAAAAT CAGTGCTCCTGGTTCTCTTTCCCTTTGGA

GGGGCACACCTGGCCCAGGGATCAACC GTATCTGGGAATGGGTCTCTGTCTTT

TCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489041 10 102323625 CCAGGCCCCACATTCCATCGTTCTTTGTT C/G TTTTGCTCTCGTTGCTCAGGCTGTAGTGC SEQ_0530

AAGGAACCCACTTTCGTGGGTTTGAAGT AATGGTGTGATCTTGGCTTACCGCAACC

CCAATGCTTTGGAGAAAGTTAAACACTTC TCTGCCTCCCGGGTTCAAGTGATTCTCC

ACTTGTCCAACAGGTGACTCTTAATTGTT TGCCTCAGCCTCCTGAGTAGCTGGGATT

CTAGGAAAATCATGGTAACTCCATTCATC ACAGGCATGCACCACCACACCCAGCTAA

TTGGATGGATGATTTGGGAATGGACATAT TTTTGTATTTTTAGTAGAAACACGGTTTCT

GATACAAC I I I I I I I I I I I IATACAAA CCATGTTGGTCAGGCTGGTCTTGAACTC

C rs2489043 10 102324317 TGACAGAGAAGAGATGTGAAAGGAATCT C/T CTCTGTCTCTGTCCCTTCCTCCCTCTCCC SEQ_0531

AGGTGCTGGTGATGCCATGGGGCCACAT CTCTCTCTGCCCCCTTCTCTCCCTCTTCC

TAATCAGAGAGATAAACAGGTAAACTGA CCTCTATTTTCCTTTTCCCTCTCCCCTAC

GGAGCTGACAGTTGGAAAGATCATCAGA CCTCCCTCTCTGCCTCCTCCTCCCCCAT

CTCTGAGCCCCTGATGTTTATGTTTAGCA CTACCTGCTTCTGTCTCTAAGAGTCCCCA

CCTGTTACATACTTGTTTGTATTGACTAT TACGCATGGCTCAGCTCTGCCTCCCATA

GTGATTTTCTAGTTTGGGAAAAACATTCT GTAAGGCATTTACTTGTGTGTCACAGGC

G rs2495735 10 102328599 TGTTAGCAACACAGCTAGTAAGTAAGTG CfT CTGCCAGAAACTCCCTTTTCTCTCTGTCT SEQ_0532

GCAGTGCCAGGATTATTCCACAATGCAA CCCCTCCTGAC I I I I I GTGGCCTGTGTAA

ATCTTAATTATGTCATATATTGTCCTAAAA CCCCTACTCATTCTTCTAACCTCAGCCCA

TCCTTTATGGGCTCCCCATCCCCTTAATA GGCATTGTCTCACACTGAAACCTTCTTTG

CAACGACTCAAATTCTTTAGCCCAGCAGA ATGCTCTGCTCTCTCCAGTTTGGGTCGG

CCTATCCACCTCTCCTGTGCCATCTTTAC TGCCTGTGGTGAACACTACAACGTGCCA °°

CTCTGGGTTTTAGTACATACTGGTCTT CTCAGATCCCCTTCAATGTGGGACTTATC

ACCAGTTGCTCGGAGTGCTAGCACACAG

GCCTCAGCTGTCACCTCCCATAGGAGAA

TGGCTTCAGCGGAAGAAAGCTCCCTGGC

CCAAGGTTACACCAACTTCCTGGGCCCA

CCCTTATCCCTGACCCATCAGTGTCAGA

GTATAAAAGCCGAGCCCTCTGGCCACAA

CTTGGGAAAAAGCTGAAGGGCCATTCCA

GCTCCAGAGTAACCCAGAGGGCAGGTCT

TGGCCCAACCTGACTCCCTCCTCTCCCT

TCCACAGGTTCTTATCTCCAGAGTTCCCT

GCACATTAATCTCCATCTCAGMTCTGCT

TCCTTGTGAAGCCCCCAGTGCTCACGTC

CCCCCAGCTAGGCTCTGAGCTCCCTGCA

GACTCTGATAAAGGGCTGGGGTGCTAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2495734 10 102328676 AAGGGCATTTTCACATGCCAGCCTGACC CfT AAATTCTTTAGCCCAGCAGACCTATCCAC SEQ_0533

TATACAATCTCACTTCATTCTTGCAACAA CTCTCCTGTGCCATCTTTACCTCTGGGTT

CCCTAAGAGGCAGGCACTATTATTATTCC TTAGTACATACTGGTCTTCCTGCCAGAAA

CATTTCATAGATGAGGCGATCAAGGCAC CTCCCTTTTCTCTCTGTCTCCCCTCCTGA

AGAGAGGTTAAGTAAGTTGTTAGCAACA C I I I I I GTGGCCTGTGTAACCCCTACTCA

CAGCTAGTAAGTAAGTGGCAGTGCCAGG TTCTTCTAACCTCAGCCCAGGCATTGTCT

ATTATTCCACAATGCAAATCTTAATTATGT CACACTGAMCCTTCTTTGATGCTCTGCT

CATATATTGTCCTAAAATCCTTTATGGGC CTCTCCAGTTTGGGTCGGTGCCTGTGGT

TCCCCATCCCCTTAATACAACGACT GAACACTACAACGTGCCACTCAGATCCC

CTTCAATGTGGGACTTATCACCAGTTGCT

CGGAGTGCTAGCACACAGGCCTCAGCTG

TCACCTCCCATAGGAGAATGGCTTCAGC

GGAAGAAAGCTCCCTGGCCCAAGGTTAC

ACCAACTTCCTGGGCCCACCCTTATCCC

TGACCCATCAGTGTCAGAGTATAAAAGC

CGAGCCCTCTGGCCACAACTTGGGAAAA

AGCTGAAGGGCCATTCCAGCTCCAGAGT

AACCCAGAGGGCAGGTCTTGGCCCAACC

TGACTCCCTCCTCTCCCTTCCACAGGTTC

TTATCTCCAGAGTTCCCTGCACATTAATC _W

TCCATCTCAGAATCTGCTTCCTTGTGAAG ^

CCCCCAGTGCTCACGTCCCCCCAGCTAG

GC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489045 10 102334744 TTGGTA I I I I rAGTAGAGGCAGGGTTTCC C/T CTGGAGGATTCTTTAAAAGTTCCATAAAG SECL0534

CCATGTTGGCCAGGCTGGTCTCAAACTC AAGGTAGATAGTTGGATAGATTGCCTGT CTGGCCTCAAGTGATCGACCTGCCTCAG CTTTCCTTTC I I I I I CCTGCCTGCCTGGT CTTCCCAAAGTGCTGGGATTACAGATGT GCGCTGGAGCTCCAGCTCCATCTTGGAC GAGCCACTGCACCCAGCCTGGGGTCAC TATGGGCCAGCCTTAAAGATGGAAGCAC ATTTAAGAAATCTTTGCCAAACCCATCAC TTGCTGAGGATCTACAGAGTCTGGGTTC TAAGATTTTCTCCTATGTTTTCTTATAGAA CTGGTGACAGTAGAACTGCCACACGAAT GTTTAATGGTTTTAGCTCTTATATTAGGT CCCAGATTGTCAAAGTCTGAACTTATTAT CTATGATACTTTTCTAGTTAATTTTAGTAT ACCAGAGAAACATAAACCCTTATGTGTCT ACAGTGTGAGGTAAGGGTTGAGGTTTAT AAGCTATTGTAATTTGACTGCTTGTAGTC TTTTGTGTGTTTGTGTTTGCACATGTGTA AACTCTAATCCTGACTTATACACCTTATAT TTCAGTTGTTCCAGCATCATTTGTTGAAA CCAAAGCTCTAAATAGTAGCCCCAGCAT AGACTATCCTTTCTTCATTGAATTGCCTT ACTTTCCAGCCTCTTCTCATTCTATCCCT GGTAC I I I I I CAAGAATCAATTGATCATC TACAAATACACATGTAGCCAAACGTCACT TATGTGTGATTTTATTTCTGGACTCTATTC ATTTGTTTTCTAAGGAGACAACTΠTGCT TGTTCCACTGATCTGTTTTTCTGTCTCTAT TTTCTGTCTCTAAGTTTTTGCTCATCTCAT ACCAATATCATACTGCACTGCAGTATCTC GCCCATTCTCCATGTC TATAATCTTAAAATTAGGTAATGTAAGCC TTCCAACTTTA I I I I i CAAAGTTG I I I I I G CATTTCCATATACACTTTAGAATCCATTTG

06 TCAAGTTCTACAAATAAAAAAAAAAGCCT O GCTGGGATTTTGAGATTGCATTGAATCTG TAGATCAATTTAGCGATTATCAGCACCTT AACAATATTGAGTCTTCCAATGCATGAAC ATATTTCTCCATTTATTTGGGTCTTCTTTT ACTTTCTCTCAGCAATGTTTTATGGTTTTC AGGATACAGGGCTTGTACATTATTGATTA AATTAATCCCTAAATATTTAA I I I I I I CTTT TTTTGAGACAGAGTCTTGTACTGTCACCC AGGCTGGAGTGCAGTGGCCCATTCTTGG CTCACTGCAACCTCTGCCTCCTAGGCTC AAGCGATTCTCTTGTCTCAGCCTCCTGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489046 10 102336272 CAAAGTAAGTCACGGGGACACCTCTGTC A/C AAGCTATATGAGACACAGCTGTCTGTCC SEQ_0535

TGCAATGGACAAGGCTGAAAAAAAATTAT CACTGAGTAGTGAGGTCCTGGCTTACAG

TACAGTTGGCCCAGCCTGCCTΠTAAGA GAGCCATGACCTGTTTATTTCTGCTCACC

GCAACAACTAATATTTACTAAGCACTTGC CTGCAGAGCCTACACAGTGCCTGCTATG

CATGTGCTGACACCATGCAAAGTGATTTA TCCTGAAGGATCAGCAGAATGATTGGCA

AATGCACTATTTCATTTAATTTAATCCACC TGAAAATGATCAAAAAGAGGTTTCCATCC

AACAATCTATGAAATTGGACTAATCGGGC TGGGAAGATGGAGTAGACATACTTTCTCT

CATGCACGGTGGCTCATGCCTGTAATCC AGTCTTTCCACTAAGTACCACTAAAAACC

CAGCACTTTGGGCAGCTGAGGCAGGCA CTGGACAATATGTATAAAGCAAACACAAG

GATCACGAGGTCAAGAGATCGAGACCAT AAGACTCTGAAACATGTAGAGAAGAAGG

CCTGGCCAACATGGTGAAACCCCATCTC CAGACCAGCCAGAGACCCTGGAATCTAA

TACTAAAAATACACAAATTAGCCAGGTGT GGAACAACATGGTGGTGAGTTTCCTGGA

GGTGGTGCATGCCTGTAGTCCCAGCIAC TTTTG I I I I I GCCTCACCTCATGTATCCC

TCAGGAGGCTGAGGCAGGAGAATCACTT AGACTTGGAGCAAAATAAGCCAGCAACC

GAACCCGGGAGGCGGAGGTTTCAGAGA TGGAAATGCTGAGTACAGACCCCACCCC

GCCGAGATCGTGCTTCTGCACTCTAGCC ACCCCTGCAAAATAAAAGCCTCAACAAAA

TGGCGACAGAGTGAGAATCCGTCTAAAA AGCCTTCTCTCTGTAGTCAAAGGGCTAG

AAAAAAAAAAGAAAAAGAAAAACATAAAG AAAGTGGGTAGCCCAGAGAGAGTATTTT

AAATTGGACTAATCTCTCCCATATTTTGT TAGACAATAACCACTCTACTCCAGTCAAA

AAGTTAGGAGACTGAAGTTCAGAGGGAT CACCACAGAAAAACCTGTAGCCCCATCC _W

TAACTAACTTATTCAGGGTCACAGAGCTT CCATTCAGGCCAGCAAAGGCTGAGTGAT 2

GAAAGTGTCAGAGCTGGAATTGGGACTC TAAGTGGTGAGCCTTAACTTCTGCCCTCA

AGTCCTGTCTGATTGAAGCCATGCTCTTA CCAGGCTGTAGTAAGGCATGCCAGCTCC

ATTGTGATCGAGTGT CTGCAGGGTATTCAGGGAAGGCCAAGTA

GAGAGCCTGGATGTTCATCTCTGCTTGT

GGGAACAAAAGTCAGTGGAGACCATGTG

AGAAGCCTATACTCTACCCCACCCAGCA

GTGATGAGGCACCCCTTCCTCTACATCA

CCGAGGAGGCCTAGTAGAGTCAGGAATT

TACACACACACCCTTGGTGTCGATGGAG

GCCATATGGGTAGCAGTAACAAGGCACT

GCTATCCCTCGCAGCTAGGGAGGTATCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9420798 10 102337018 TCTGCAATGGACAAGGCTGAAAAAAAATT A/G TACTCTACCCCACCCAGCAGTGATGAGG SEQ_0536

ATTACAGTTGGCCCAGCCTGCCTTTTAAG CACCCCTTCCTCTACATCACCGAGGAGG

AGCAACAACTAATATTTACTAAGCACTTG CCTAGTAGAGTCAGGAATTTACACACACA

CCATGTGCTGACACCATGCAAAGTGATTT CCCTTGGTGTCGATGGAGGCCATATGGG

AAATGCACTATTTCATTTAATTTAATCCAC TAGCAGTAACAAGGCACTGCTATCCCTC

CAACAATCTATGAAATTGGACTAATCGGG GCAGCTAGGGAGGTATCAGTGGAGACAT

CCATGCACGGTGGCTCATGCCTGTAATC TGGTTGGGAGCTGGAACTCCTACCTCTG

CCAGCACTTTGGGCAGCTGAGGCAGGC ACCAGCAGCAACAAGAAGAGAGGCCAAA

AGATCACGAGGTCAAGAGATCGAGACCA TGGGAAATCTGAACTTCTACCCTACTGTG

TCCTGGCCAACATGGTGAAACCCCATCT ATCAGCCCCCTCACCTGCTAGAGCGATG

CTACTAAAAATACACAAATTAGCCAGGTG TCAGAGGAACTCAGCTAAAAAAGAAAGTT

TGGTGGTGCATGCCTGTAGTCCCAGCTA TAAATAAGATCAAGAGTCTCATAACATAC

CTCAGGAGGCTGAGGCAGGAGAATCACT CCAAAACATCCAAGTTTCAATTAAAMTC

TGAACCCGGGAGGCGGAGGTTTCAGAG ACTCATCATACCAAGAACCAGGAAGATCT

AGCCGAGATCGTGCTTCTGCACTCTAGC CAAAATGAATGGAAAAAGACAATCAATAG

CTGGCGACAGAGTGAGAATCCGTCTAAA ATGCCAAAGATGTTAGAATTATCTGACAA

AAAAAAAAAAAGAAAAAGAAAAACATAAA ACATTTTAAAACAATCACCACAAAAATGC

GAAATTGGACTAATCTCTCCCATATTTTG TTATAAAACAATTATGAACACCTTTCAAAC

TAAGTTAGGAGACTGAAGTTCAGAGGGA AAATGAAAAAAGAGTCTCATCAAATAAAC

TTAACTAACTTATTCAGGGTCACAGAGCT AGAATATATAAAGGATAAACTAGAAAAAT &

TGAAAGTGTCAGAGCTGGAATTGGGACT TAAATTGAAAAATATAATAACAGAAGTAA ^

CAGTCCTGTCTGATTGAAGCCATGCTCTT AAACTTTGATGGATGGACTCAAAAGCAG

AATTGTGATCGAGTGTAAAGCTATATGAG AATGAAAAGGAAAGAAGAAAGAACCAGA

ACACAGCTGTCTGTCCCACTGAGTAGTG AAACAGGAAAATGGAACAATATAAATTAC

AGGTCCTGGCTTACAGGAGCCATGACCT CATATCTGGACAACAGAGAGAAAATACA

GTTTATTTCTGCTCACCCTGCAGAGCCTA CTGAAAATAGACTGCAGGACTATGATAAA

CACAGTGCCTGCTATGTCCTGAAGGATC ^■ AGATCTAACAGTTGTGTCATTGGAGTTTC

AGCAGAATGATTGGCATGAAAATGATCAA AGAAGAAATGAGAAAGAGAGCAGGGCTG

AAAGAGGTTTCCATCCTGGGAAGATGGA AAAAAGGACTCAAAGAAAGAATGGCAAA

GTAGACATACTTTCTCTAGTCTTTCCACT ATTTCCCCAAATTTGGCAAAAGGTATGAA

AAGTACCACTAAAAACCCTGGACAATATG TCAATAGATTCAAGAAGTTTTGTGAACCC

TATAAAGCAAACACAAGAAGACTCTGAAA CAAACAAGACAAATGCAAATCTGTCCTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9420801 10 102340888 GAAAGGAAATGATTAGAAAAAATATTGGA A/T GAAAATAAATGTAGAAACACTCAAGAAAA SEQ_0537

ACGTCAGGAAGGAAGAAAGAACACAGCA TACTAGCAAATAGAACCCAGCAATATATA

AGCTAAAACTGGATAAATACAATAAACTT ATAAAAATTAGATACCATGAGTAGTTGGA

TCCTTCTCCTCTTAAATTTTCTAAATTGTG GTTTATTCCAAGGATGAAAGGCTGATCCA

TTTGACTATTGAAGCAAAAATTATAACAC ATATTCAAAAATCAACTAATGTACTTTACC

TATCTGATGTATGTAGGGGCAATATGTAA CTATTAACAGACTAAAGAAGAAGAATCAC

GTCAATTATAAATAGATGAGGATAAAGGG ATAATCATATCAGTTGATGCAGAAAAAGC

ATGTAAAGGGAGATAAAGTTTCTACAGTT ATTTGACAAAATCAAATTGGAATATCTAA

CACTTGAACTGGTAAAATTATAATGACCA ACCGGTGCCATAATACAAGAAAAGGAAA

ATAGACTGTGATAAGCTACATATATATAT TAAAAAGCATACAGATCAGGCCAGGCAC

ATATATATGTTACAAAAGCTATATGAAGT AGTGGCTCACACCTGTAATTTCAGTACTT

GATACACTCAAAAACAATACAGAAAAATA GGGGAGGCCGAGGCGAGTAGATTACTT

AAAGTAGAATTCTAAAATATGTTCAAGTT GAGGCCAGGAATTCAAGACCAACCTGGC

ACCCCAGAAAGGCAGGAAAAAGAAAACA CAACATGGCAAAACACTGTCTCTACCAAA

AATAAAAAACAGAAATAACAGCAAACAM AATACAAAAATTAGCCAGGCGTGATGGC

AAATAAAGTGGCAGACTTAGGCCCTAAC AAATGTCTCTAGTCCTAGCTACTCGGGA

ATTGATAATTACATTAAATATAAATGGCCT GACAGGCACGAGAATCGCTTGAACTTGG

ATGTACATAAACTAAAAAACATAGCTTGG GAGGTGGATGTTGCAGTGGGCTGAGAAC

CAGAATTGATTGGTATTTATGATCCAACT ATGTCACTGGACTCCAGCCTGGCAAGAT

ATATGCTGCCTATAAGAAACTCACTTCAA TCTGTTAAAAAAAAAAAAGCATACAGATC W

GTATAACTATATAAGCAGACTGAAAGAAA AGAAAAGAAGACATTCTTTTCTGCTGAGA W

AAGGGTGGAAAAAGATATATCATACAAAT AAATCCAAAGGAATCTACAAAAAAAGTTC

GTGAATCAAAATAGGAATGGCTACATTAA TAGAACTAAAAAGTGAGTTCAGCAAGGTT

TATCAGATAAGGTCTACCTTAGAGCAAAG GAAGAATACAAGATAAATATGCAAAAACA

AAAATTATCTCAGATGGAGAGGGACGTG TCGATTGTATTTCTACATACTAGCAATGA

ATGTAATTATAACAGTGTCAATCCATCAA ACAGATGGACACTGAAATTAAAAATGAAA

GAAGACATAACAATCCTAAATGTCTATGC CACTATTTACAGTCACTCAAAAGTAAAAT

ACCAAGCAACAGAGTTGCAAAATATGTG AAAATACTCAGATGTAAATACAACAAAAC

AAGCAAAACCTGATAGAACTGAAGGAAG ATGCAGAACTTGTGTACTGAAAACTGCAA

AAACAGACAAATACATAGTTGAGGACTTC AATGCTGATGAAATAAATAAAAGAAGATC

AACACACCCTCAACAATTGATAGAACTAA CAATAAATAAATGAAGAGACATACCATAT

ATAGATAGAAAACCAAAATAACTCAACAA TTACAGATTGGAGGACTTAGCCAAGTGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9420802 10 102341775 AGAACTAAATAGATAGAAAACCAAAATAA A/G TATTTACAGATTGGAGGACTTAGCCAAGT SEQ_0538

CTCAACAATACCATCAACTATTAGGGTCT GTGGTGGCTCACCCCTGTAATCTCAGCA

CATTGACATTTATAAAGCACTCCATTCAA CTTTGGGAATCTGAGGCAGGCAGATCGC

CAACAGCAAAATACACATTTTTTCCAAGT TTTAGTCCTGGAGTTGGAGACCAGCTTG

GCCCATAGGACATATGCCAAGATAGAGC GGCAACATGGCGAAACTCCATCTCTACA

ATATGCTGAGCCATTAAACAAACTCAGCA AAAAATACAAAAAAATTAGTCAGGCATGG

AATTTAAAAGAATTGAAATCATATAGAGT TGATGCACACCTGCAGTCATAGCTACTC

GTGTTCTTTGACCACAAATGGAA I I I I IA AGGAGGCTGAAGTGGAAAGATCATCTCT

AAAAATTGAATTGATAATAGAAAGATTGC CCACAGCCCAAGAGTTCCAGGCTGCAGT

AAGAAAATCTTCAAACACTTGGAAACAAA GAGCCATGATCATGCCACTGCACTCCAG

ACAACACACTTGTAAATAATCCATGGGTC CCTGGGTGACAGAGTGAGACGCTGTCTC

AAAGAGGTAGTCACAAAGATACACCAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAATT

CTGAACAAAAATGATAATACAACATCTTA GGAAGACTCAATACAATAAAGATGTTGAT

AAATTTGTGAGTCATAGCTAAAGCAGTGG TCTTCCCAAGTTGATATACAGGTCTAACA

TGACAGGAAAATTTATAGCACCAAATTTA AAATTCCTGTGAAAATCACAGCAAGATGT

TGCATTAGAAAAGAAGAAAATTTCAAATC TTTGCAAATATAGATAAGATTATCCTAAAA

AACCATCTAAGCTTCTACTTCATGAATCT TTTATCTGTTAAAGGCAAAGGAGCTAAAA

AGAAAAAGAAGAGCAAAGGAAATCCAAA TAGCTAAAAACAATTTTGAAAAAGAAGGA

GCAAGTGGAGGAAGGAAACAATAAAGAA TAAAGCTATAGTAACCAAGAGATTGGTAG

AAGAGCAAAAGCCAACAAAACTAGAAAT AGGTATATACACATAGATTAATGAAACAG W

GTGAAAATGATAGAGAAAATCAGTGAAAC AATAGAGAATCCAGAAATACAGCCACAC £

AAAGAGCTAGTTCTTTGGAAGATCAATAA AAATATGCCCAGCTGATTTTTGGCAAAAG

AACTAATAATCCTCTAGCAAGACTGACAA TACAAAAATAACTCAATGGAAGAAAGATG

AAAATAAAGAATGAAGACACAAATTACCC GTCTTTTCAACAAATGGCTCTGGAGCAA

ATATCGAGAATAAAACAAGAGATATCACT GTGGATATCTGTAGCTACCCCCTGCCCC

ACAGACCCTGCAGACATCAAATGGATAA CACCCCCACCAAAAAAAGGAAAAAAACC

TGGAATACTATGAAAAACTACACATATAA TCAACCTAAGGTCTCACACCTTATTCACA

ATATTGACAATTTAGATGAACTGGACAAA GTTTAACTTGAAATGAATCACAGGCTGGA

TTTCTTTAAAAATACAAACTACCCCAACT CATGGTGGCTCACGCCTGTAATCCCGAC

CCCCCAACAGGAAATAGATAATTTGAATA ACTGTGTGAGGGCAAGGTGGGCAGATCA

GCCCTCTATTAAGGAAATTGAATTCATAA TGAGGTCAGGAGATCAAGACCATCCTGG

TTTAAAAACTCCCCAAAAAGGAAATCTTC CCAACATGGTGAAACCACGTCTCTACTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489053 10 102343331 CCTAGCTACTCGGGAGACAGGCACGAGA CH^" TGAGATGAAATATTAGCAAACCACATGTC SEQ_0539

ATCGCTTGAACTTGGGAGGTGGATGTTG CAACAAAGAACTAATATCTAGAATATATA

CAGTGGGCTGAGAACATGTCACTGGACT AAGAATATTTAGACCAGGCACAGTGGCT

CCAGCCTGGCAAGATTCTGTTAAAAAAAA CACACCTGTAATCCCAACACATTGGGAG

AAAAGCATACAGATCAGAAAAGAAGACAT GCTGAGGTGGGTGAATTGCCTGAGACCA

TCTTTTCTGCTGAGAAAATCCAMGGAAT GCCTGGGCAATATAGTGAGACCTCATTT

CTACAAAAAAAGTTCTAGAACTAAAAAGT CTACAAAAAATTTTAAAAATTAGCCAAGC

GAGTTCAGCAAGGTTGAAGAATACAAGA CTAGTGGTGCGTACCTGTAGTTCCAGCT

TAAATATGCAAAAACATCGATTGTATTTCT ACTTGGGAGGCTGAGGTGGGAGGATTG

ACATACTAGCAATGAACAGATGGACACT CTTGAGCCCGGGAGGTGGAGGTTGAAG

GAAATTAAAAATGAAACACTATTTACAGT TGAGCCATGATCACGCCCACTGCACTCC

CACTCAAAAGTAAAATAAAATACTCAGAT AGCCTGGGCAACAGAGTGAGACTCTCTC

GTAAATACAACAAAACATGCAGAACTTGT TCGAAAAAAATAAATAAATAAATAAATTTA

GTACTGAAAACTGCAAAATGCTGATGAAA AAAAGACCATTTAAAACTCAACAGTAAAA

TAAATAAAAGAAGATCCAATAAATAAATG ACAAAACAAAAACCAATAAACCAATTAGA

AAGAGACATACCATATTTACAGATTGGAG AGATGGGCAAAAGACATGAAGAGACATT

GACTTAGCCAAGTGTGGTGGCTCACCCC TCTCTGAAGAGGATATATACATATGGCAA

TGTAATCTCAGCACTTTGGGAATCTGAG ATAATCACACGAAAAGATGTTCAGAAAAA

GCAGGCAGATCGCTTTAGTCCTGGAGTT TTAGCTCATTAGGATAA I I I I I I I AAAAAA

GGAGACCAGCTTGGGCAACATGGCGAAA CCCAGTGAGATATCATACACGCCTGTTG &

CTCCATCTCTACAAAAAATACAAAAAAAT GTAGTGGGATTGTACCTATGAATAGCCA ^¹

TAGTCAGGCATGGTGATGCACACCTGCA CTGCACTCCAGCCTGGACAATATAGCAA

GTCATAGCTACTCAGGAGGCTGAAGTGG GACCCCATCTCTTAAAAACAGAAAAAAAA

AAAGATCATCTCTCCACAGCCCAAGAGTT ATGTAGGTGACAATCCCAAATGCTGGCA

CCAGGCTGCAGTGAGCCATGATCATGCC AGAATGCAGGGATGGTCACTGACACATT

ACTGCACTCCAGCCTGGGTGACAGAGTG GCTGGTGGGGATGTCAAATGGTATAGTC

AGACGCTGTCTCAAAAAAAAAAAAAAAAA ACTTTGGAAAATAGTTTGGCAGTTTCTTA

AAAAAAAAAAATTGGAAGACTCAATACAA AAAAAATTAAACATACACTTATCATAGGA

TAAAGATGTTGATTCTTCCCAAGTTGATA TCCAGCAAGTGTACTCCTAGGTGTTTATA

TACAGGTCTAACAAAATTCCTGTGAAAAT ATGATGTCCTCACAAAACCTGTACACAAC

CACAGCAAGATGTTTTGCAAATATAGATA TGTTCATAGCAGCTTTATTAATCATAACC

AGATTATCCTAAAATTTATCTGTTAAAGG CCAAACCGGAAATAATCCTGATATCCCTC rs2489001 10 102348387 CAGCCTGGCTAA I I I I I I I I I I I I I GTATT A/T AGTTTCTTCTGGCTGATTCCAAAATCTAT SEQ_0540

I I I I I GTAGAGACTAGGTTTTGCCATGTT GCTTTTGTGTGCTACACTATATTGTTTAC

GCCCAGGCTGGCTTCTATATATATCTAAA AATATTTATTTTGTCAATGAACAACCAACA

TTAATCATTACCTGAAGAGAGTAGGATCA CAAGCAAGTATGCAGAGGATAGGTAAGG

TCCTATTTTATAGATAAGGAAACTGAAGC GCTTGGATGTTGGAAAACATTTTCCTACC

TTAATGAAGTTCCATAACTTTCCCAAGGT GTCAGAAAAGTGTTCCTCGAAAACCAACT

CTCATAGCTACTAGATGGTAGAGGC GGCTCATTCTTAGCAGTTTCCTGAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2489003 10 102350845 AAGG I I I I I I I CTTCCACTGTGTGCATCC A/G TTGCACTGGGGACACACACGTTTAGACC SEQ_0541

TGGCTAGGCTGCTTTGCATTGTCACCAA ATAGCACATTATATGGACCAAGCTTTGTC

CCAGGGACCCAGGCATTGCTCTAAGAAG TTAGTTCATTTTCTGCTGCTATAGCAGAA

TCCTGCGGTTTATAAAAGTTAAMTCCTG TACCACAGACTGGGTAATCCATAATAAAC

TTTACATCTGTTTAGGCTTCTGTTTCCCA AGAAATTTATTGGCTTGCAATTCTGGAGT

GATTATGTGACCACAGAACGCTTTTCTCA CTAGGAAGTCCAAGACTGAGGGGTTAGC

TACCTATTTACATCCCATCTTAGTTCTTCT ATCTTGCAAGGACCTTCTTGCTACTCACC

GGACTGCTACAACAAAATACCTTAGCCT TCATGGGAGAAGGGCAAAGAGAGGTTGA

GGGTAATTTAAAAACAATGGGAATTCATT GAGAGAACAGGGGGCTGAACTCAGCTTT

ACTCGCAGTTCTGGAGGCTGAGGAGTCC TTATGACAAACCCAGTCCTGCTATAACAG

AAGATCAAGGTGCCAGCAGATTTGGTGT CATTAAATTCATTCATGACGGTGGTACCC

TTGGTGAGAACTTGC I I I I I GCTTCAAAG ATGACCCAAACATCTCCCATTAGGTCCCA

ATGGTGACTTCTTGAGGTATTCTCACATG CCCTGCAAGACTACTTCATTGGGAATCAA

GCAGAAGGGACAGGGCAGCTCCCCTCA ATTTCTTTTC I I I I I I I I I GAGATGGAGTT

ACCTCTTTTGTAAGGAAACCAATCCTATT TAGCTCTGTCACTGAGGCTGGGGTGCAA

CATGAGGTAATCATCTTCTAAAGGCCCCA TGGTGTGATCTCTGCTCACTGCAACCTC

TTCTTAATACC CACCTCCTGGGTTCAAGCGATTCTCCTG

ACTCAGCCTCCTGAGTAGCTGGGATTAC AGGTGCCTGCCACCACACCTGGCTAATT

TTTGTA I I I I I AGTAGAGACAGGCCAACC &

ATGTTGGCCAGGCTGGTCTTGAACTCCT °"

GACCTCAAGTGATCCGCCTACCTCGGCC TCCCAAAGTGCTGGGATTACAGGTGTGA GCCACGGTGTCTGGCCTTTATTTCACTTT TTAG rs4074720 10 114738487 TACCCTGCCTCTCCCTTTGCATGTCAACA A/G ATAGAACCACAAGAGGACCTCAAAAATG SEQ_0542

TAGCAACCGCAGAGCATGACAGGACCCG TGAGCTTTCCCCTCTCTTAACATGCACAT

AGCCTCAGACAAGGCCCAGACTCAATCC CACGGAATAATGCCAGCCCCATTTCATAA

AGCGCTGCCACTTGCTAGCTATGTATCC CTGGAAAAATTGAGCCTAGGCTCATATTT

CTGGGCAAGTCCCCTACCTTCTTTGAAAT GCATTAGTGATAATACTAAGGTTCAAACT

TCTGTTTTCTTATCTGTATAACGGGGATG GGTGTACAGAAAGGAAACTAAGAGAAAA

ATGTTTAAAGGCATTGTGAGTGTTATGTT TTAAAGGGTGAGTGGCCCACTCGGCCTA

GCAATATATAATGTCCATATATAGAGAAA TCTCCAAAAGGAACCACAGATGGGAGGC

CTGGCAGATAGAGCTCAAAAAACACCTA AGGTAGAGAGTGACCCACACTATTCTCA

TTC I I I I I I CTTGTTGCTATTAAGGTTATT TTTAGTCAAGTGGAAGAAAGATAAAAAGA

TCTGGAGGAATGATTGCTGAATAAACAAA CGCCTTGAGCCAAGGGAAGTGGTACATA

GCGTGAGTTCCTACACAA AGACAGAAGCTCAAAACAACACAGGGCC

AGGTGCAGTGGCTCACGCCTGTAATCCC

AGCACCTTTTGGAGGCTAAGCGGTTGGA

TCACCTGAAGTCAAGAGTCGAGACAGCC

TGGCCAACATGGAAAACCCCTCCTACTA

AAAATACTAAAAATCAGCCCAGCCTGTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4074718 10 114738607 TACCCTGCCTCTCCCTTTGCATGTCAACA CfT CATATATAGAGAAACTGGCAGATAGAGC

TAGCAACCGCAGAGCATGACAGGACCCG TCAAAAAACACCTATTC I I I I I I CTTGTTG

AGCCTCAGACAAGGCCCAGACTCAATCC CTATTAAGGTTATTTCTGGAGGAATGATT

AGCGCTGCCACTTGCTAGCTATGTATCC GCTGAATAAACAAAGCGTGAGTTCCTAC

CTGGGCAAGTCCCCTACCTTCTTTGAAAT ACAAAATAGAACCACAAGAGGACCTCAA

TCTGTTTTCTTATCTGTATAACGGGGATG AAATGTGAGCTTTCCCCTCTCTTAACATG

ATGTTTAAAGGCATTGTGAGTGTTATGTT CACATCACGGAATAATGCCAGCCCCATT

GCAATATATAATGT TCATAACTGGAAAAATTGAGCCTAGGCTC

ATATTTGCATTAGTGATAATACTAAGGTT

CAAACTGGTGTACAGAAAGGAAACTAAG

AGAAAATTAAAGGGTGAGTGGCCCACTC

GGCCTATCTCCAAAAGGAACCACAGATG

GGAGGCAGGTAGAGAGTGACCCACACTA

TTCTCATTTAGTCAAGTGGAAGAAAGATA

AAAAGACGCCTTGAGCCAAGGGAAGTGG

TACATAAGACAGAAGCTCAAAACAACACA

GGGCCAGGTGCAGTGGCTCACGCCTGT

AATCCCAGCACCTTTTGGAGGCTAAGCG

GTTGGATCACCTGAAGTCAAGAGTCGAG

ACAGCCTGGCCAACATGGAAAACCCCTC W

CTACTAAAAATACTAAAAATCAGCCCAGC ?α

CTGTT rs17747324 10 1 14742493 AGTTTCTCGAGGAAGACTCCATGCTTTG CfT GTTACTCTCTTATA I I I I I CTTTC I I I I I I I SEQ_0544

GTTCTGGCCCCTGGAAACCCCTCCTGAG I I I I I l GAGACGGAGTCTCACTCTGTCAC

GACTGGACCTCCAAGCAGACCCCCTCTG CCAGGCTGGAGTGCAGTGGCACGATCTC

TGACTCCGGAATGCAG GGCTCACTGCAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7901695 10 114744078 TGTACCTAGGTTGCAAGATTCCTCAGGG CfT GGGCTTTTGTGTCTGTCTGCTTTCACTTA SEQ_0545

TGCACCTGGGCTTATCGTTATCTGTAAGT GCATACGGTTCTCAAGGTTCATCCAGTAT

TATCCCAGCAAGCACTTAAAACACAGTGT TGTAGCATCTATCAGTATGTCATTCCTTT

TGGACGATGAATCCCCTCTACAAGAGAG TTATGGCCAAATAATATTTTATTGTATGGA

GGACAGGGCAAAAACGACACCTCTTGCC TAGACATTTTGTTTATTCATTTATCTGTTT

TCGCAAGCTGTCTTGGGCCAAACCTCAG TTGGTTATTATGAGTAACACTACTATGAA

GTCTATTCTTTC I I I I I I I I GAAAGTAGTG CATΠTGCACAAA I i I I I GTATTGACATGT

GCTGGGCACGGTGGCTTACGCCTGTAAT TTTCATTTCTCCTGGGTATAGTCCTATGA

CCTAGCACTTTGGGAGGCCAAGGCGGG GTGGAATTGCTGGGTCATATAATAAATAA

CGGATCTTGAGGTCAGGAGTTCGAGACC CTGTTTAACATTTTGGGGAGCTGCCAAAC

AGCTTGGCCAACATGGTAAAACTCCATCT TTTTAAAACCTTGGGTTCTGTGATGTACC

CTACTAAAAATACAAAAATTAGCTGGGCG AGTTGTGTTAGGCAGCACAGCAAAATGT

TGGTGGCGCATGCCTGTAGACCCAGCTA GACTTTTGATTGCCAGAAACAATATTTAA

CTCAGGAGGCTGAGGCAGGAGAATCACT AAAGTGGTTATAAAAAGTGGTTTGGGAG

TGAACCTGAGAGGCAGAGGTTGCAGTTA GCTGAGGCAGGAGGATCACTTGAGCCCA

GCTGAGACCATGCCATTGCACTCCAGCC GGAGTTTGAGACCAGCCTGGGCAACATA

TGGGCGGCAGAGCGAGACTCTGTCTCAA GTGAGACCCTGTTAAAAAAAAAGAAGGC

AAAAAAAAAAAAAGAAAGTAGCAGCTCTA CAGGCACAGTGGCTCATGCCTGTAATCC

CTGAGATATTTAGAAACCATAAAATCCAC CAGCACTTTGGGAGACTGAGGCGAGCA

CTATTTGAGGTGTACAATTGAGTGATTTT GATCACCTAAGGTCAGGAGTTCCAGACC W

CTGTATAGTCACAGATCTGTGCAGTCATC AGCCTGGCCAACATGGCGAAACCCCATC OC

CACACCCTCTAACTCCAGGACATTTTCCT TCTACTAAAAATACAAAAATTAGCCAGGC

CACCCCCGAGGAGAAACCTCCCTTACCC CTGGTGGTGGGCGCCTGTAATCCCAGCT

ATTAGCAGTCACTCCTCATTTCCTCTCCC ACTCAGGAGGCTTGAGGCAGGAGAATCG

CCCAGCCCCTGGCAATCACTGTGGATTT CTTGAACCTGGGAGACTGAGGTTGCAGT

GCCTGTTCTTGACATTTCATATAAATGGT GAGCGGAGATCATGCCATTGCACTCCAG

ATCATAAAATCTA CCTGGGCMCAAGAGCGAAACTGTGTCT

CAAAACAAATGAAAAGAAAAGGCTGTCAT

GTTAGATCCACCCTCCTCCTCAGGGGAA

CCCCTGGGCTGCTCTCTGGGTAGAGATG

GGAACCCAGGCCTCGGGCCAGTGAGTG

GAAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4506565 10 114746031 TAGGGGCTCCAGAAATATCTGTGAGTAA A/T TGGGGCCCTTGTCAAGGGTCTCTATTAT SEQ_0546

ATAAGTTATTTAATCTTTGCCTCAAATTTC GGCATCAAGAAAAGATGCTGCTTTCGGT CAGTGACTGTAGGGATATAGCTGTGAGC GATGCCCGAGGAGAGCCTCAATATTTTA CTCTAGGAGCTGAGA I I I I I IAAATTTCC CATGGGAAACCTAAAAAAGGGGCCATGT CACTTAAACATTTATTTAAAAATTTTGTGC TGTGGTCTCTGCACCTAAGATACTAAAG TCAGCATGGACTAAGGACTTTACATTCAT GAAATATTTTATGGAGAGATGCAACATGT TAACTCATTTACAGCTTGATCCTATGCGG CAGGCCTTGGAGGGAAACCCCAGGATC TGGGCATTCATTTACAGAGGATCCCATTT CAGATGGTTGCACTCTCAAACCAGGGCC TACAGGTGAGGAAGAGGCCAGCTAGGG CCCCTCACCTTGGCCTTCAGCATTTAGT GTGCAGCCTAGGTTAGTATTCTAGAGCT GTTGGAACCAATAGCATAAGCTTTGGTCA CATCAGGCTGTGTTGTCCCCAGTGAAAG GGACCTTTGATGGAAGCCACAGTGCTCA AATAAGCAAAGAAGTGAATGTTGTGCATT TTAGTGACCACGGTTGACTACCTTCTCTC GAGAAAAATGACTCTCGGAGGAGGATGA TCCTAAGCTGACTTCTGGAGGGCACCTG GCCTCTCGGATATGGCGACCGAAGTGAT GGATTTCCGGCCAGTGATCAGTGCTGGT GAAGCC rs7903146 10 114748339 TTTTGGATCTGTTTCTTTAATTGTAAATTG CH^" TATATAATTTAATTGCCGTATGAGGCACC S EQ_0547

AATCGGACTAAAACCTTTCCAA I I I I I I C CTTAGTΠTCAGACGAGAAACCACAGTTA ACATGTGAAGACATACACAAAAGTTTTAT CAGGGAAGGCAAGTAACTTAGTCAATGT TGGAGGGTTGCACATGTGAAAGAAAAAG CAGATAACTAGGAAAAGGTTAGAGGGGC GGAGAAAGCAGGATTGAGCAGGGGGAG CCTGGACACAGGCCTGTGTGACTGAGAA CCGTCAGATGGTAATGCAGATGTGATGA GCTTGGGCACTTCACTGCTACATTTCATC GATCTCTGCCGGACCAAAGAGAAGATTC TCTTCGCTATAAACATΠTAGC I I I I I GTG C I I I I I AAATGGTGACAAATTCATGGGCT TTTGCTGACTGGCAACAATACATAGTGAA TTCTCTGCCTCAAAACCTAGCACAGCTGT AGTTCTAATAATTTGTAATGCTTTTGCATG TATTTACTGAACAATTAGAGAGCTAAGCA TCTTTGTATTTTTCTTGGTTATCACATCAC C I I I I I AGATA ATCAAATTAAGATACTGATCAGCAGTGTG

AGAGGTTA I I I I I CCAT rs 10885402 10 114751687 CCTTGATCATACTCGTTGTTTACACGAAG A/C GCCCAGCTGTTTAGAGGCTACGAGACGT SEQ_0548

GGAA I I I I I ATTGTCTTGTGAGTGTTGAG GAGGCAMTCCTGGTATCTCTCTTTGGG TGATGATTAAACAGAAGAGATGTGACTCC CCTCAGTTTCTTCATCTGTGAAATGGCAC AAGCCTGGCTTCACTAAGATAGTCTTGTT AGTACTACCCTCCACCAAGGATGATGAT TGTTTCTTTTCCTCCAAAGTAATTTCCTAA GAGAATTAAATGGGATGACAGGTTTCATC AGAATTAAAAGCCCCTTTGAAACCCAGCA CCCAGCTCCTGTTCTTAGGAAGGAAAAA CTACCTTGTCTCTGATTATCAGCATAGGC CTGTGACTTATGAAGCCTGTAGGTTGTGT AGGAAGGGCTTTTAAGGTCTG TCAGGTTTGTATGAGGCCTCGGACTTCA

TACAAAGGTATCAAAGTGGCAAACCCTG

ATCCAGATGTTTTCAGTTCAGTCAGCTGG

TCCTTGAGCCTGTTGTGTGCCAGATATC

CTGACCAAAGAAGCTAGATGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6585198 10 114752227 GAAGCCTGTAGGTTGTGTTCAGGTTTGT A/G TGACAGGAGTCATCCAGCCCAACATGTC SEQ_0549

ATGAGGCCTCGGACTTCATACAAAGGTA ACTAGTGCTGCAGTGGAGAAGCCCTGGC

TCAAAGTGGCAAACCCTGATCCAGATGT TGTGTGTGGGGGTGTGTGTGTGTCCTCT

TTTCAGTTCAGTCAGCTGGTCCTTGAGC TCTACATTTGATAAGGTAACTCACACTTG

CTGTTGTGTGCCAGATATCCTGACCAAA CTGCCCCCATGATCGCTGTGGGGGATGC

GAAGCTAGATGGGAGCTGCTGTGTTGTT TTATCTATGCCCCAGTCCTGGTGTTGGTT

CCTTGGGGCTGCTGGATGCAAGTTGTTT GATGGGAACATCAAGATTCAGGCAAGAT

AGGTCGGCGGTTTTCAAATGCTGGTGAT GGAAAATAGCCCTTAGAACTAGCAGGAA

TTTGCTCACCAGAGGACATTTGGCAATGT AAGAATCTCCTTTCATTTGTCTAGAGGT CTAGAGACATTTAGCATGGCCAGTCA-|T GGGAGGTACTCCTGGCATCTCGTGGGCA GAGGCTAAGGATGCTATTGAACATCCTG CAATGCCCAGGACAGCCCCCT rs4132670 10 1 14757761 GAATTCTGGCAGCATAGTGCTGATATCAT CH^" GCTGCTATGTCTGGGCTGCACACTTCCC SEQ_0550

CAGGGTCTCAAGACCCCACAGAAAGGTG CAAGCCCCAAGTCAAGCTGCCTGCCTGC

ACGCTGAGTGCCGCTACGCAGAGAGACA CCAGGCTTNCTTGAATTC

GGTGTATCTGGGGGCACTGAGAGGCTAA AGGGCAGCTTCACGATGCTGGACACTGA

CCAGGAAGATGTCCAAGGATGCTCTGAG _W

CATACACCAAAAAGGTACCCAACGCAGG g

TGTGGGGAAGATGACCATCCCCAGAGTT GAATCGTATGCCAAATAGAATCAGGGCC AAAATGGGTTTGAAAACCTCTCATACAGA GCTTTGGATGAAAATCTGAAAAAAGGAG CATTGCAGAAAATGTTAAATTAAACAACA ACCAAAGTGTCTGCAAAGCTCAGCAAGA GATCAAGTGGAGAAGACGATGGGTCGCT TTCACTTTTGCATGTGATGAAATTCTCAT CTCAGCCCTCAGCCCTGAGGCCCTCTCA T

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 33'' FFllaannkkiinngg SSeeqquueennccee SEQ ID rs6585200 10 114758599 CTGTGAAATTATAGGTTTGATGTGCTACT A/G GGCCTTCCAAGGGGGGAATTTTAAGGTTTTGGCCTTCCAAAACCCCCCAAGGGGTT SEQ 0551 TATTTATTTA I I I I I IAATACACATTAGTAT GTGGCCTCAAAATTCTGCTCATGGAATA AATCCCGTAACGGCTAAAGTAACACTTTG GCCTCAGGCTTCTATAAATCTCATCTTTT TACTGCCTAAAACCATGCTTGGGAGCGC TTGTTTTG I I I I G I I I I I G I I I I I GAGACT CACAGTTTGAGAAAGTGCTTAGCCTTCCT GAGTCTTGCTCTGTTGCCCAGGCTGGAG TTCCCTCCTTTAGTGACTTGTGGTTTGGG CACAGTGGCGCAATCCACTGTAACCATT GCATCTGTTGACTCCTAGGGCTCCCTTG GCGTTCTGGGTTCAAGCGATCCTCCCAT TTCATCTTTCTGTTCCTA CTCAGACTCCCAAGTAGCTGGGACTGTA GGCTGGTACCACCAGGCCCGACTAATTT TTAAAI I I I I I GAAGAGATGGGGTCTCAC TATATTGCCCATGCCGGAAGTCTAGTTTT ATAGTGATGAGAATTCATCTGGGGTCCA AGGGGCCCTCCTGTGTTGCTTCCTGTGC TCCCCTCTAAATAAAGATACTCCTTCCAA GTTGTCCTGATTTTCAGGTCAT rs6585201 10 114758773 ATGCTTGGGAGCGCCACAGTTTGAGAAA A/G TTCTGGGTTCAAGCGATCCTCCCATCTCA SEQ_0552 GTGCTTAGCCTTCCTTTCCCTCCTTTAGT GACTCCCAAGTAGCTGGGACTGTAGGCT GACTTGTGGTTTGGGGCATCTGTTGACT GGTACCACCAGGCCCGACTAATTTTTAAA CCTAGGGCTCCCTTGTTCATCTTTCTGTT I I I l I I GAAGAGATGGGGTCTCACTATAT CCTAAGCTCAGGGATTAGTTGCTCAACC TGCCCATGCCGGAAGTCTAGTTTTATAGT CAGGTGTGGCCTCAAAATTCTGCTCATG GATGAGAATTCATCTGGGGTCCAAGGGG GAATAGCCTCAGGCTTCTATAAATCTCAT CCCTCCTGTGTTGCTTCCTGTGCTCCCC C I I I I I I GTTTTGTTTTG I I I I I G I I I I I GA TCTAAATAAAGATACTCCTTCCAAGTTGT GACTGAGTCTTGCTCTGTTGCCCAGGCT CCTGATTTTCAGGTCATCACCA I I I I I I G GGAGCACAGTGGCGCAATCCACTGTAAC AGCTGGATGGGGAAGTTGGCCTGGAGC CATTGC AGCCTTCCCTGTCTCCGAGTTGCATTAC CTCCTGAGAGGTCT

Supplementary Table 3

SNP Chr Position S' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7904519 10 114763917 ATCAGTAAGTGCTGACTGACTGAGGCGC A/G GGTCGGCATTCAGCTGAAACAGTGATGG SEQ 0553

CCCACACATCCGGCTTCCTTCTGTTACTC TTAAAATTCTGAAAAATGTCCACGCTCTG TACGCGTGTTGCTGAAACTTAACGAACC CATTCTCTTCCTAACACCCAGGACCCAGT CATGTGGGGTCTTCTCGCCTGGTGCAGT AACTATAAAGCCCCCTACCCTGGGGCAT CCGGCCCAGTATTCATACTGAGGTTTGC AGCAGGGGGCTTCAGGGACCCATGAGA AGTGGGAGAAAGGAAGGTATTTATTTGTA AGGTCATCTGCTGCTAGTTACACTCCTTC GGTCACCAAGCAGGGCAAATCCAGCAGC TGGGACCTGATTTAGACAGTTTGGTGGT TCACGCTTAAGACCTGACCTCTCCCATG AG GTTTATAAGCAAGTGG I i I I I I I I I I I I I I I I I I I I I I CAGACTGAGTCTTGCTCTGTC ACCCAGGCTGGAGTGCAGTGGCGTGAT CTCAGCTCACTGCAACCTCCGCCTCCCA GGTTCAAGCGATTCTCCTGCCTCAGCCT CCTGAATAGCTGGGACTACAGGCGTGCG CCCCCACACCTGGCTAAGTTTTGTCTTTT TAGTAGAGATGGGGTTTCACCATGTTGC CCAGGCTAGTTTCCAGCTCCTGACCTCA AGTGATCCTCCTGCCTTGACCTCCCAGA GTGCTGGGATTACGGGCATGAGCCACAG TGCCTGGCCTGTAAGCAAGTG I I I I I AAA GAAAGGGGTAAATTTTAGGGAAACAGAA κ> GTTCTAGGCAAAATGGTAAATTAATACAG GGAGGTAAGACATTGGTTTGGCCTAAAA AGATGGGATATTTTGAAGTGGGGGCTCA

TAGGTCATAAGTGGATTTAAAGA Π I I I I T

GGTTTGTAATTGGTTAAGGAAGATAAGCT TTGATTAAAGATTTGGGGTCAGCAGAAA GAAATGTTAGGTCTGGCTCGTGGGCATG TC I I I I I CTAGGCCCCTCCTTGGAAAGAA CTTTAGAGCAAAGAAAGGCAGTTGGAGC TTAGTCCCCACTTTCTCCTGATCTGAGGT CTACGGACCACTGGATCCATTTGGTGGG rs10885405 10 114767660 AGACACCCTCTCTGGTCACCGCAGACTT C/T CTGGGGTCTTTAAAATGCATCC I I I I I GC SEQ 0554

CCTGCCCTCCATCCAGTGTCCTTCTACTT AAACAAATAAACTTAGTGTATTAAAAGGG GCAGGATGTGTGCCCAGCAGAGAGAATC CTGGAGAGAGCAGAGTAAGGTAACATTT TCTGAAGCCATGTCATTATTGGGATAACA GGGTGGTCAGCATGTAGTTCTGGGTCCC TTCCTGTCCCAGTCACCTTATTTCTCAGA CACAGTGGAGATGGCACAGTGCTGGGT AAAAGGACAATGGGAAACAAG I I I I IATT GCTGGGGGAACTATGGTCACTAAGAGAC GAATCCTATGCTGGGCCTATTAATGGGG ACTGAATAATTTAATGCATGCCCCTGATT TCTCTTACTTTTCATAGCAGCACTGCAAA CC CAGAGTTACGTTTCTATTCATTTTATGGA TTAGAAAGCTGAGATCCAGAGCGGGCAG ATGTAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10885406 10 114767714 CTTGCAGGATGTGTGCCCAGCAGAGAGA A/G AGGGCTGGAGAGAGCAGAGTAAGGTAA SEQ_0555 ATCTCTGAAGCCATGTCATTATTGGGATA CATTTGGGTGGTCAGCATGTAGTTCTGG ACATTCCTGTCCCAGTCACCTTATTTCTC GTCCCCACAGTGGAGATGGCACAGTGCT AGAAAAAGGACAATGGGAAACAAGTTTTT GGGTGCTGGGGGAACTATGGTCACTAAG ATTGAATCCTATGCTGGGCCTATTAATGG AGACACTGAATAATTTAATGCATGCCCCT GGTCTCTTACTTTTCATAGCAGCACTGCA GATTCCATCACTGACTGTTGAGGTAACAC AACAGAGTTACGTTTCTATTCATTTTATG ATACATTTATATTGTCAGTGGTGGTGATG GATTAGAAAGCTGAGATCCAGAGCGGGC ATTACATGAGCTGCGTAAAGCGTTTGAC AGATGTAAACCTGGGGTCTTTAAAATGCA CAGTGCCTGCACATAACATAGTAGGTGC TCCTTTTTGCAAACAAATAAACTTAGTGT TCAATAAAGATCACCCACTCTT ATTAA rs 10787472 10 114771287 TGTTAGATGATTCTGCTACTTATTATTGTT A/C TAAGCTGCTGCCTGCAATTATGATTTGGG SEQ_0556 TTC I I I I I CTCACCACACACCTTCCCTTTT AACAACTCTGAAAGTAGTTACCTCCCATT TATGTACACCTCCTAGGAAGTAAGTTTCT TTATAGAAGAGTAAACTGAGGTTCAGAGA GATAACATACTGCATTGTTGGATAACAGC GGTTAAGTAACCCCCCCAGGGTCTCTCA AACAAAAAGCACTTCCTGACATTATTGCC GGAAGTAGTTGGTGGCCTGGGATTCAAA CAAATCACCAAATGAGGCAATTACCAACT CACCAGAATTGGTCTGACTTCCCACTCTT TTGGAATAAGAATAGCAACGGTGGTAAG TAAACCACACTCAAAACTGAACTCTCCAC AGCTGACATTTCTTGAGCGCTTGCCATAT GTGTGTGTGTTCTGGGCATTTTCGCATCT GCTGGGTGTACTACT CCCTTGGCTTGTTGACAGCGTGGACTTT TGCTTTCCCATTCTCATAGAACATGGCCA GTGCAGGAGGAGGAAATCCACACTGGTC TTTGGACTGAACCAGAGGCTGGCGATGG TCCCGAAACAGGGTGCCAAGTGGCTGAC CCTTGTTTT rs7924080 10 114777002 GGTCAGCCCTGGCCTTAAACATGAGAAA CIJ GCTTATTTC I I I I I GGl I I I I GAAGCAGG SEQJD557 ATAAAGGTGGTCCTTGCTTTGGAATGAGT AATTTGATTTGGTGTCTGGGTTTTGATAG TAGTGGTGCTGACTAATTCAACTGGTTTT GGGTGTTTATGTTTCATCAATGTCTTTTG TC I I I I I C I I I I I GGAAGTGGAATTTGATT GTTCTTTCAGCGTTTCTCTCCTTGTCTGT TGGTGTCTGGATTTTGATAGGGCCATTTA CATGTGTCAGAGAGGGTGCCTGTCAACG TATTTCTTCAGCAC I I I I I GGTTCTTGCA ATTCTCTCTCTCCAGGGAGAAAGTCTTTC GAAAGTTACATTCCTAGTTCCTCAAC TTAAAACAGCCCTAAGATCCTTATCTC rs12243326 10 1 14778805 TAACCCTTCCAGGTCACCAGGACCCTGT C/T ATCCTTCAAGGTTGAATAAATGATGTGGG SEQ_0558

TACTTGCTGGCTTTGTACCTCTCAAAGGT AGCTAGTCAAGGGGCTTTAGGTATGTGA CATTTGTTGGCTTCGTCTCTTAACAATTT TTTCATGCCTAC I I I I I I I I AGGTAGAGA CCATGGTAGACCTAAAATTTCTGGCTGTG AACTGAGGTCACAGGGTACTAGAGAATG AAATCCCCTGTGTAGTGGGAAGAAGAAA GACTCTAAGATTCAGGTTTCTGAATTGCC TAGCAAATCTTAGCTGCCTTGGACCTGAT TGTGGTTTTGTTGACTCAACTGCTCTTCT ATAATTATTTGTCTTCATTTACATGGTT GTTG I I I I I IAGCCACATGCCTTGAAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7077039 10 114779067 ATGCCTAC I l I I I I I IAGGTAGAGAAACT C/T CTTTCACAAGGTCTTGGAGTTCCCATGC SEQ_0559

GAGGTCACAGGGTACTAGAGAATGGACT CTTTGTAAGCATCCCTCCCCGAGATTCA CTAAGATTCAGGTTTCTGAATTGCCTGTG GCACCAACCAAAATCACATTTGGAAAAAT GTTTTGTTGACTCAACTGCTCTTCTGTTG TGCTTGTTTCCCAAGAAGCTTTGGAGGAT I I I I I I AGCCACATGCCTTGAAACAGTCC ATGATTTTGTATAGAACGGGTTCACAGGT TCTTTCCCATGTTTCTTCATCAGCACCAT, TTTCTGTTCATTCTTCTATGGTGGAGTGT TAACCCAAGGTATACTGTCCTCTCTTA GTGTGTATGTGACTCTGTCTTCTCTCCA rs7900150 10 114783813 TGAAGGGACTTGTGAAATAGTTTCACAGA ATT GGGCTGAATTTTCCATCGTCCATTTCTGA SEQ_O56O

GTTTCAGTGTTAGGTATATTTGATCAATG GAAATGAGGTAGGTTTAGAAAGAGACAA

CTAACTTTTGGAAAACTTTGGTGCCTGTA TCAGGCCTCTTCTTTAACAGAAATGTTTG TGATTCAGAGGGTAGGGCAGAATATTAA TGTCTACTAGGTGTGTGTCACAATATGAG ATTAATCACAACTTCTTGTATΠTAACCAT TTCCTGAAGAAATAAGTGTCCGCTATTGG TCTGGGTAAATTGGGATTCCGTGACGCC GTTGTATACTTGTACTTCCTATTTTCTTAT

CAGGCAAAATTATTTGTTTATAGAAGA TTTGCACATTTTTCTGGTATTTCCCT rs7100927 10 1 14786038 AGGAAATACTGGAAATACTGGAAGCCAC A/G AGGATGAAGGCCCCTCTATGGGAGCAG SEQ_0561

TTGGTGTTTTATCAAGGATGTGAGGTTTC GATCAGTCTGGCTTTAGTAGATGCCAATT CTGGCAACTTTGTCGCCATATCATCATCA TCTGCTAAGACTATTTCCTAAAGGAGCCT TCATCACCATCATCATCATCATCATCATC CTCCTCATTTGCCTTTTCTCCCTGTTTTC ATCATCATCATCATCATCATCATCATCTG ATTGGGGGAGGTGGAAGAGGAGAAAAAT CCCTTTAAGTTTTCTGCTTGTTTAGAAAA AATTAGAGATGCTCACC I I I I I C I I I I I G GAAATTTATACAGAGCCCCCAGTAGCAG CTGGCAATTTAACAGTCTTTTCAGCTGCT CTGTAAGGGGGCAGGTTCTTGGAGCAGC CCATCCTCAACATTCTTGCTGCTGATGGA AGATTCTC rs7895340 10 114791515 TGCTGTGGCTGGTTCTGTTTTGCTGACT A/G TGAAGAAGCCTGTTTTCAGGTTTCCCGC SEQ_0562

GTAAATTGGGTCATGGTCAGGGACAGTG CTCCCTGAATTTCCCAGCATGGTCCAGG CATAGGTGTAAAGAAGTTGCTGGTTGGG CTTTGAAATTTATTTATCTGCTTTTGGCAA GGTTCTAATGCAGGTTTCTCCAAAAGTGA TGGTTGATGGGAATTTCCCACATTTATTT ATGCCCTGTTAAAAAAAAATTCTTAACAA TTTAGCTACAGAGAAAGGACATTATCTTT ATATACAGAGA I I I I I I I I I IAAAAAAGTG AAAATCTCTTCGTTGTTCTCTCTCTTTGA TGACAGTTCTAGACACCTAGAGAGTAAA GTGAGGAGAGAAGATGTGAATCCTGGC rs11196200 10 114791928 TGGACACAGCCCCTGTGTTTGTGGCATA C/G AAAACATTCCTTCCAGAGCCTGTGTGGAT S EQ_0563

GGCTCTGTGGGCCCCATGCCAGGGAGC TTTGGCCAGGGGTGCAGCAAGGGGGCT AGTACCCCCGTGTAAAGGAGTGGGGGTT TAGGCACCTTΠTCCTCTGCTGTGTCTTA TGTCCATTTGGATAGAGCAAAGATCCTCC GCAGGCGTGTTGACCATAGCAACTCCCC ACCTCAAATCCCACAAGAACAGTTGCCA TGGGGCATACACACCCTCTTGTAGATGG CAACCTGGGCCCTAAGCATCTCATTTTCC AGACCTTTGTCCAAAGCAGCCACAGCTG TATGTAGAAATTAATGATCTGGAGGAGAT GCAACTGTCTACAATCTTTTGGGCTTTCT GG GC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11196205 10 114797037 TAATΠTGTATTTAAAAGTTGTACCTCTAA C/G AGCAGTATGTAAGAGAGTTATGGTTGGA SEQ_0564

AGTAAGTGAAATTTA I I I I I AAACGTAGC ATGATTTTAATGTCTCTGGGGAATTTAAC TTTCTTCATTCATAAAGTTTATGTTCATTG AACAAAAAAACTTTAGGCTTCTTTGGAGA TAGGCAGTTTGGAAAACAGCCCATAATCT GAGACATGCCCTTAACTCCACCCCGCCC CACCACTCGGAGATTACATTGTGAATAAT TAGAACAGAGACCCAGCCCATCCAAGTC TTGGTATATTTCCTTTTAGAAATATACCAA AGCCTCCCCAGGTCCTCCACCTTCAAAA ATTATCC I I I I I l CCTCTGAGTGTATGAAT CAGGCAAACGAAATCATTTCTTGAATAAT ATTTATATTTG I I I I IAACATACTTGAGCT T CATAGTGCTCAGTATTTCCAACGTTCTGT TTATTTAAGATGAAAATTGCTGTAGTTAAT AAGCACTTCCCCATGTCATTAAAATGCTT AAGGATTTTTAATGACCACATAACAGTCC ATAATATGATTAAACCCCAATTTACTGAAT CAATGCCATATTGTTGGGTCTTTAGATTG TCTCCTTTTGTTTCTGCTACTGTGAATGA TCCTGTGATGATCATCTTTGTGTGTAAAT CTTTGTCCCCTCGCCCCCTCCCCTTTTAT TATTTTCTTGGGATAGACCCCAGGACAAA AGGTAGAAAAGAACAAAGTGTTAAAAAAT TTCTTGATACATAGCCACAGATTATTTTC CTGAAAGTTCTCAACATTTATAACTAC rs10885409 10 114798062 AGGGGCAAGATTGGGACCTACTTTGGAA C/T GCTGATTAACTCTATGGATGGGGCATGT SEQ_0565

GGTTG I I I I I GTTTCGGCACCTGCTCTGT TTCTCCAACCAGATTGTAAGTTTCTTGAA TTACGAAGCGTGGGAGCCTGTTTTAAATT GCCAAGGAGCCCTGTGGTTGATTTCTTC AATGTGCGCCTACTTAGAGCTACACTCAT ACATGTGGCTCTCTCTCCTCCCACAATG GGTTTTGACTATGTTTATCTTTCCAGTAA GTGCTTCGTTAATTAAGCAGAAAACCCAT ATAAAACAAAATTGTTCATTTGGCACCCA CTCTGGTTAGGGACTGGAGTTGATTTCG GCCTGTCCTGCTTGTCATTTCTTGTCT TTTGGAATGAGTGTGACTTCATCATGACC T

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12255372 10 114798892 TTTCATC I I I I I AAATTAATTATCATAGAA G/T ACCATATTCTGATAATTACTCAGGCCTCT SEQ_0566 GGAGAAAACAACTGGATTTCAGAATTGTC GCCTCATCTCCGCTGCCCCCCCGCCCCC CCTTGAGGTGTACTGGAAACTAAGGCGT TGACTCTCTTCTGAGTGCCAGATTCAGC GAGGGACTCATAGGGGTCTGGCTTGGAA CTCCATTTGAATGCCAAATAGACAGGAAA AGTGTATTGCTATGTCCAGTTTACACATA TTAGCATGCCCAGAATCCACGTCTTTAGT AGGATGTGCAAATCCAGCAGGTTAGCTG GCACTCTCTCCCCAGCTCCAAACCTGTT AGCTGCCCAGGAATATCCAGGCAAGAAT ACTGCTTGTGTTCAACATCTCAGTAAAGC TCMCAACATCGACCCATTACTTAGGCCT CAAACCTTGGGTGGCATCGTCGATTGCT CTTTTCTTTCATACCCCACATTCAACCCA TCAGCCCATCCCACAGGCCCAAGTGTGT CCTCTCTACCTTCAAAGCGTGTGTGGCA TCCACCGCTTATCACCACCTCTGCCATTA CCACTGGAGTCCAGTGCCATCATCTCTC ACTTGGATGTGGCCAGAGTGTCTTTGCT GGTCTCCTTCTTGCTTCCTACCTTTGTAA CAGCCTATCATCTATCTCTGGTCTCCATA GCTCACTCCCATACT rs 12265291 10 1 14800230 TGCTGGGGTGAAAAAAACAGCAAGCATT CfT AGCCCTTTCAGATTGAAAGGAGACGCCA SEQ_0567 TGAAAAGGCTGAAGAAGGAAAGAAAGCT ACCTTGATGGGTGGAGGTAGAAAATAAA GAGAGCGGTACAGCCTTGGGGACTGAG GTCCCAAAACAGTGTCTTGTAAGCGAAG CCATCCCATTGTCCCAGAGGTGGGGGTG GGGAACATGGCTGGGCAGAGGGCTTCT TTATCAAGACCTG I I I¹¹I IGAGCCATACCT GGTGAAACTTTTGGGAGTATTCAGTTGG CTGACTCTTCCTGGAAAGTTAGACCCAA AACTCAGGAAAAAAAAATTG I I I I I I I GG CTCAAGAACACACTAAGAGAAGTGTTTCC AAAGAGGTAGCAGCCCCCTTCAGCCAAA CCC GCTC rs11196208 10 114801306 GGTGAGGCGGAAATGCCTGTATGGCACC C/T TGCAAGAGCAGAGCACGCATGCTTTCTT SEQJ3568 ATGGAGTTCTGTGTAGCCAGTTCTAATCC TAAGAACAGGTTGGTTTGTGGTCGTCTG TGGGCTATTTGGTAAGGAATGAAGTTGG AGGACTGTTTTAAGGAGACTTATTATACA AGATAGTCTTCTGTCCCTTACAACCAAAG CAATCATCCCCCACAAATGATTTCTAAAG GAATTCTAACTAATAGTTTGCCAAGTTTT AGAGGCTGGTATGAAAGAAGGAGTTTCC ATGTTTATAATAAAAAATGACATGC I I I I T ATGATTCTGTCCTGTGGTTCTGGGGAATT CTTTTGGATTTTTAATGCTTTTGAATTAAA CTGAAAATGAACTTTAGATA I I I I I GTGA AATGCTAGAACATGAACTGATTCTTCTAT CGCTATTTAGATAGAGCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7077247 10 114802061 AAATTGGTGGCAAGCTGAGCATACAGTT C/T TGATGGATTAATTTCTGCCAAGGCTGAAA SEQ 0569

GTrTATTTCTGTTTGACTGATTATTACAAC GAGGAGAGAGTAAGAGGCTGTAGAGGT TTCATTATTTGATGAAGGTTCTGTACGTT GTCACAGCTGTCATTGCTGTTTTAGGCA TTCCTTTAAGACACATAGAAATTGTGAGA GTCAAGCTTTTGGGAAAGTGTCAGAAATT AGATCCTGCAGCCCCGAAAGGCTACAGT GAGCCCCCTACTGGATCTATCGGAGCCC GTTGATCCAAGGACTCTGAGCCGAGTGC TGTCAAATGTCCATTTAGATGTCCTGGTG AGGGTTTGTACTTGGACCTGCAGGCTGG AACAAAAGTTCTCTGACTCACCATTTAAA GTGGCGTCTGTGGGAGCAGTGTGTTGAG AACTTGTTCCAAATGAAATTATGGGAGAA AGAGATTCTGAGGCTGTATGTGTCAGGG AGGAACAI I l I I C CCTCCAGGGGAAGGATGCA rs12718338 10 114803037 CTCATGGTTAAGTTTTGGAACATAATTTG C/T GGAGGCCAGCAGGGTTGGGCTTGGCTA SEQ_0570

AAAAATGTAACCCATTGAGAGGCAGTAA AGTGCTGTGGTGTCTGGATGCCTATGTG GGACATACGGTGAGCTAGTGCGTGTTTG AGTTTCCTCCAGAAGTTTTCAGTTGGCAA GACGTCTGTGTGGAATAAGTGAGTGGGT AGTAGAACCTGCTGGATATGTAGCAAGG AGAGAGGACATTTGTCAAGGAGCGGGAG GTGTGGATTGTCGGGATCCTGCTGGGCG GGCGGGCCATTGGCTTGGGGGAAATGG CAGGCGTGTGATACCAGAGGTCAGAACA GCTGAGACTCTAGGGGTGGCCAGCACC GAAGCTGAGGGATGAGGCTTTGGGAGCT GCATA rs11196212 10 114811239 TGGATGACAGCAGTTCTCTGTGCCTCGC CfT TCCAATTTCCCTCTTATGTCTAGGTGTGA SEQ_0571

TGGGACAGAGTGTATTCTGAGGTCCAGC GTGAGGATACGTGTAGTAATTGTCGCAG GTCTGCATGGAGATCTGCCTATCCTTCA GTATTAGTGAGAAAGGGTGCAGATCACA CTTGGGGTGCTCAGTAGATAACGCGGCC CAAATATTTCACACGTTATTAGTTGGACC ACTTTCCTATACATTTCCTTAATTTAAGGG AGACTTTGGAGGCAAGGGAGGGCCGTG AACAGCGTAAACTCAGCCCAGGTGGATT TCACCTAGGAAATTTGCTCTTCCGTGGA AATCTCTCCAGTGACTTTTGAAACTTCAA GATGAAAGGGCAGTGAATTAAGTGCCTG T CTT rs1 1196213 10 114811544 TAGTTGGACCAGACTTTGGAGGCAAGGG CfT GAACGCACTAGCAGGTGAGGAGTTAAAA SEQ_0572

AGGGCCGTGTCACCTAGGAAATTTGCTC GTTGGCAACGCCTGCCCTCTCGAGAGTG TTCCGTGGAGATGAAAGGGCAGTGAATT TCAGGA I I I I I AGTCTCTTCCTTGAGAGC AAGTGCCTGC I I I I I CTCCC I I I I I CCCT TAGAAGATGTTTCTAAAAGAATCTCTTTG CTGACGGTTATTGATCCTCCCCTGGAAC GTGACTTAGAAGTGGAGAGAGCTTTAGA TGTACAGTTCACGTTCTGATC I I I I I CTT AGCATGGCACAAATAAAAGGAAAGAGGC GACAAAGGGAATTCCCAGTTTGTTCGCT AAACACCGTCATTCTACATCTGTTTATTTT GG rs4918789 10 1 1481 1797 AGTGTCAGGATTTTTAGTCTCTTCCTTGA GfT TGAGGGTGTAGAGAGCAAAAGTGTGAGT SEQ_0573

GAGCTAGAAGATGTTTCTAAAAGAATCTC TGTACACCATGACTGGAATCGCTTGGAC TTTGGTGACTTAGAAGTGGAGAGAGCTT ATACTCTTCAGCAGACATCGTGTGACTGT TAGAAGCATGGCACAAATAAAAGGAAAG GGAAGAAATGAGTTTCATGAAGATGACT AGGCAAACACCGTCATTCTACATCTGTTT GATAGAAGGAAGCCACTGAACCAGTCCT ATTTTGTTATTAACAAAAGGCAAGGCGAT CTATCACCTCTTCCAAGGCTAAAGTTTGG TTTCATTAAAGTTTTGCTGGGGTTGGGG AGCCACTTGCAGAAGGCTCTCCTCAAAC

CC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7087006 10 114813416 TGGCCCTGGAATGTGGCACTGCTCTGGC A/G TGCTTCTGTTGAAACCCCCACACCCGGG SEQ_0574

TGGAGGGAAGATGAGAGTGAGGGATGG TGATTCCTTGCCTCTCCCAAGGAGCCGG

AGAGGAGAGGAGAGCGGGAGATGGGAA AGGGTGGAGAAAGCAACAAGAAAAAGGA

CCTGGTGGACACAGGAGGGAGTGTGAG GCCAAGAAAAGAGCAATGAAAGAGTTCT

TTCTGAGGGCCAAAGGAAACTTGACACC TTAGGAAAAGGGGAAGGTCCCGAGAGAT

GGATGGGACATTAATCTGATTCTGTTATC CTGGTAAATGTTAAACTGAAGGGCCAGG

TGAGGCTGTCACCAGTCCTCCCTGTCCT CATGAGGAAGAGTAGGCAGTAGGAGAAG

CCTGGC AGTGTATGTGTGTGTGCACATGGATGTG

GCGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTTTC rs1225404 10 114904655 TAGTAGGGCCTTCATGTACAGCTGTGCA C/T GCTAGGGAACACTGGGACTAAGAACCGC SEQ_0575

GGGCGTGCACTGCACAACTCTAGAGTAT AGCACTGAAGCTTTTATGCATTTGAATGT

GTCATTTACACTGGGGTCTATGTGAATG G

GTGCCCCCTGGAGTTGTGCAGGGTGAAA

TCTCTACAAAGGTACAAGGCAGACTGTG

ATAGCTTCAAAAGAATACCGTGTTTGACT

TGCCTGGGAGTCGTTTAGAGAAAGTATT

GCTCGAGGC I I I I I GTGACATACTTTCTC

GGTTTCAGAAGGGCTGTTAGGCACTCGA

AATGACTTTAGCTCAGTTTTAAATTTGGA W

AGATGGTTTGGTATAATAAGGGAACTCCT ∞

GAGACGATTTGAGGTTTAGAGATCTGGA

TTTAGGGCTCTAGGAACTTTATCTCTTGT

AAGAGGTACTTAGATTCCTATTACAATGG

CTCATTACACATGGGTGTGAACACACAC

ACTCACACTCACGCCTTCCTTTTATG rs290483 10 114905204 AACCCCTGGGATTATATTTGACATTATTT G/T TTTATCCACTTTCTCATGTCTTC I I I I IAT SEQ_0576

CC I I I I I AACCCTCTACACTGGGTAAAGG TAAAACACAATCCCTGTCCTCCAGAAGTC

ATAGAGGTCCCATGCCATTTGCTCACCT TCTAGTCTAAATGACAACTTCTTCAGTAG

GAGTTTCTTTTCTTCTACCCATATCGTAG TCAACATCTCCGTGCTATATCCTAAAGGC

GCCCTTTCTTTCTTCTGTTACATTTAAAG ACAGCTTCTTTGTGTGTAGAGGAATΠTC

GGGTAGTAGCGTGGCCACTTCCCTGGAG AGATGCCTTCACAGTATATTGCAAGGAAT

ATGCATCTTCCTCTTCACTAAGTGTAGG TGGAAACGGGGATGC I I I I I CACAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2442422 11 4966456 CAGGAAATTTGACTAGGTTCCTATACAAT A/C TCTCTCACTCCAGTATATAGATCAGAGAC SEQ_0577

TACAAAATACATGACTGCAACCAGTTATA CTATATACTGGAGTGTTCACTCTATGCCA ACA I I I I I IAGGTATTTTGGATGCTTAAAA TATAGAAGACTAAGAAAGTGAGAGATGA GTTTGGAGCAAATTCATAA I I I I I I I AGAA GCAATGGGGCTGAATTAGGCACAGAAGG ATTGAAAGTGTGTGGTAGACCGACTGGG CACAGTGCCTAGGGCCCAAAAACACTTT AGATTACTCAGTCAATGTGAAGGTCCCAT TAGGGGCTACAAAAAATTAA I I I I I I I CTT TAATTTATTTGAATGATTTCCCTTG AAAATTAGAAGAGAAAAATGAACACATAG ATAGAATAAAATGTTTTCATGTGTAATATT AATGTGTGTATTTATCATTATACCATGCA GTCACACATACACACACACACGAAATAA GAGCCCACAATGGTCACCATGTAATAAT GTGGTCCTGAGTCGTTCACCTACCTCAA CAAAGTCCCATCCTTTATGGTCT

ΓS2499946 11 4967229 AAATGAAATGGGGAATGCAGAACCAGCC AfT GTTTATCCATGTTATTTTTATTCTGTCACT SEQJ3578

AAATTTTATGTCCTGGAGTGATTGATTGT TCTCATTCATATCATTTCACTGTGGCATA ATCCTGATTAAGAAAACCTCCATCAGTCA AAGAATCAGGGATGGCTGCCATCATCTG GAAAGACCAGAGGCCATCTTCCCCGGG ACTGAGAACAGGAGACTTAGGAAGGCCA GAATTCCCAGGTAATATCTTCCTGTCGTT GACTAAGTACCGTCCTTCTGAGACCCTC TATACTTGGGTTTCTCCATCCTAAAACTT AAAGAAGGCTATGCCCAGGGTAACTGAT GGAAGCTTTTTCTTTTAAAAAAATGTTAT ATATGGGTCTTCCCTATTGACTCTTAGTA rs2499953 1 1 4967481 GTGGCATAAAGAATCAGGGATGGCTGCC A/G AGAAGGAGTCGCCACTCCTTACCCAGGA SEQ_0579

ATCATCTGACTGAGAACAGGAGACTTAG GACACAAACACAGCTCCTGCAACAATTC GAAGGCCAGACTAAGTACCGTCCTTCTG CATCGGAATGGGACAGACCTACTTGACA AGACCCTCAAAGAAGGCTATGCCCAGGG TGCAGATGCATGCTCTGCTACACCAGCC TAACTGATATATGGGTCTTCCCTATTGAC CCACTGTGGGGTGCCTGATGGGTCCGA TCTTAGTACTCATCCTTCTTGATCTGATT CACCTCCATCTCGCCAGGAAGATGCAAG CAGGGCTATTTCCATCAA ! I I I I CCTGAC TGGAATAAGCACACTCTAACTTACAGGTG C CTTG rs2499956 1 1 4968083 CTATCCTTTCCCTTTGTTAAATCTTTTCTT OT ATATTTAATTTAATTTAATTTTGTTCACATT SEQ_0580

TTTAATTTTAATGCGTGAGTGTGTGGATG GTTTTATTTACTTA I I I I TCCCCAACCACC GTTCTAAGGTACAATTTTGAAAACTTAATT AGATAGGACTGTCATTCTTAGACTTTAGC TCTGCCTAGGTTACTCTTTCTGTTGGGGA TGACCTAAGAATAATTTGGGATATTGTTA TTCTAAATATACTTGAGATATCTAAAGCA AAATTCTTAGAAATCTATATTTGCATGTTT AGCAGTACTAAATTATGTAGAATGCTATA AATTCCTTAAGTTTCTGATTTAATTAGTCT CATTTTAATTTATGTAGAATGCTG GAAATTAGCTCAACTTTATAAATAACCAA

AATGAGTCCTAAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4445619 11 42202178 GAATACATTATAAGTGTACAAGTTAATATT C/T TATCCTCAAATACTTATCTTTACACCCCA SEQ_0581

TTGTATATTTTGTTTTATACTACATTTTCA CCGGCAAAAACACATTTGCTAAG I I I I I C

CATATTATTTCTTTTCCTTTTATAi I I I ΠC AAAAAAA I I I I I I I I GTGTGAAAAATGTTT

TTTATG I I I I I I ATTTATTTATTTATTTATT GTGGGCTTAGATTTTGCTACAAAGAGCAT TATTTTGAGACTGAATCTGACTCTGTCAC TTAATTTTATTTCTTCTTGTTGTTTTGAGA CCAGGCTGGAGTGCAGTGGCATGGTCTT AAAATGTTCAACGATTTATGCATTATTAAC GGCTCACTGCAACCTCTGCCCCCCGACT ATACTGCACATTGTATTGGATTA TCAAGCAATTCTCCTGCCTCAGCCTCCT GAGTAGCTGGGATTATAGGTGCCTGCCA CTGCACCTGGCTAA I I I I I GTA I I I I I AG TAGATACGGAGTTTCACCATCTTGGCCA GGCTGGTCTTGAACTGCTGACCTTGTGA TCCACCCGCCTTGGCCTCCTGAAGTGCT GGGATTACAGACATGAACCACTGAGCCA GGCGTGTA I I I l I I C I I I l I I ATATGATTG CAAGTATACCATGTATACACTATTGATTA ATTCC I I I I IATTTATCATTTCTAAATTATC ATGTGTCTGTAAACTATAAAATATCAATTA AAATTGCTGTATAGTATTCCACTGAGTGA TTGATTAATTTATCTTGCCAGTATTACCTC TTTAGATATCGAGGCTGCTTTCCATTATT O O TTTATTATAACTAGCACAACCAGCAATAT CTTTATTCAGAACCACAAGCATATTTGAT ACATGGCATAATAACATTATGAACTTATT C rs7480010 11 42203294 CTCCTTGAGGACAATAGTTTTGTATATTA A/G GGCCATTATACGATCACGCAGAGTAATG SEQ_0582

CATTTCTATATAAGCATAACTTAGCCCAA AAGTTATGCAGGTAAATCTCCTTAAAAGC GTGTCATAAAAGATATTTAATAAATCTAG AGCAAACATCCTTTACC I I I I IATTTTAAA GCCTATCAAATAAGTATAATATAAACCAA AAATTAAACAGAAAATTAAATGCAGCAAC CACCAATGGTGTGACACAATTAGTTTTGA ATATATTAATTACTATATTGAGTACAAAGT AAGAGAACAGATGACATTGTAGGTATAAA TAAACAGCCACTAAATCATGAAGTGCAAA CATCAGTTTGGTGGATAACTCAGATG AAG I I I I I CCTATAATTGTAAACCCATCC ACGTTAAGCAAATGTTG

ΓS6485307 11 42204903 TCTGAAATCAAAACTAGGCTTGCAAAACT A/G TGAAATACATAAAGGTCTTGCAATTACTC SEQ_0583

GATACCAAGCACCATTAGAGATCAGTACT CAGGAGAGGATGCTTTTAGAATATGGTC ACCACTTGTTTGCCTTTAAAAAAATGTGG TTCCTCTAATAAAACTCATCCCTAACTCA GGTCACTCAGTAATGAATTTTGCTCCCCT AGCTCATTTACATTGTTGTTTGTGAATAT TTAGTAGGATGCTAAATGAATACTGCCAG CCCTCATTAGAATCGCCCTTACTCAAAGT TAATTGTATAAAATTAAGACTTTATACTGG ATCTTTCCTGTTTGTTCAGTGTTCAGTGT CTCCATTCAATCCCAGGAATGGATA TCCTGGGGGGAAAAAATCTCATACCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7483599 11 42212613 TAGTCATTTACAGATCTCCTTATCTGTGC C-T TTGAAAGGATAAGTCATAGGGAACTCCT SEQ_0584

CAGCCAC I I I I ΓΪAGGCACCAAAAATGCT GTCATAAAGACCATGAGCTGTCTGCTGT AAAGACTCTTGCTTAGCAATGTAGAAAGC AACCCAGCAGCCTGAGGGCTGAAGAGA AGTCTTTATTGTGGGCAGGGAACA I I I I I GTGGTTCTAATAGGTGGATGAAATTATAG GCAGATAATATGACTTCACAGAGCATTTC TCACTGCCTTCCAAAATATCTTATTCTATT CAATTAAAAGTTGGGTACAAAACAGAGAT TCCATAATAAGCTAGACTATAAATGAGTT TTTTGGGTGATTGCCTTGGGGTAAGG ATGTTGAAAGATAATAAATAAAAATGTGA rs 1 1036787 11 42225316 GTTAAGAGAGCACATACAGAAATTAAAAA C/G AGTCCAGACATATTAAAGATAAACAACTA SEQ_0585

AAAAATATTATGGTATCTTCAAACCAGAG ATTACTTATTAATTGCTTCTCAATC I I I I I AAGGAGAAAACATTTAATTACAGAGTGAA TCAACTTAGACTGGTTTCATAGATAATTTT ATTGATGCTGTTTTGATAGCTGAAAGTAC ACACTCTCTAGAAAACACGATAATCTTAA AATCTTCTACCTCTAAATTATATTAATTAG CTTTGAATATAGTCTAATATTACATATGAT AAGGTGGAGGTTTTCAGCCCCTATTACA AATGGTAATCACTCATTTCAGAAACCATA CGCTCAGCATGGTGCTTGGGTTGGGGGT GGATTCCCTCTAAC I I I I IACAT TCAGTAATAAACAAGAAAGATTCAATTTC TTGGCATTTGCGGCATCACTTAGTTTTAT ACAATCCTCACAGCAGCCTCTGTAGGTA GATCTTGTCTTCTTCATTTTACAAATGTG CAAACCAAATTCAAGGAGGTGAAGTAATT TGTCTATGATCACATATGTAGGAAGTGTT GGAGTCGTAACATGAACTCAAGCC I I I I l TATTTTGAAGTCTAATTATTTTCGCTATAC TTGGATTCCTCT rs10837800 1 1 42241041 TTTTAACAAAAGGTGTAGTCAATGTCTTG CfT TCCAATATAGTAACCTGTGGGGGAAAAAT SEQ_0586

GTTTCCAGAATGGCCTGATTCCAAAGTTA TACTTTAATATTATAAAATCCACAAAGCAA ATCAGTGGCTTTTATTAATACAGCCCTAA ATAAGTCAATTCAGGATTCACTGACTTCT ATTATACTTGACCTTTTGTGGGTGGTAAA TAGACTAGGGCAGAATTCCAAACACTTTT AGAATTTGTCATCATAAAATATAAACCAA ATGTTAGAAAAATCAACTCCCAGGAAATG ATATATGCAATGA M i l l GTGAGCATGCA AATGTCGTCAGTAACTAACAGTAAATATG CACACACATACTCACTCACAATTTAG AATGATCTCCACATATAACAGATCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs178523 11 44053802 GGCGAGACCCTCTAAATGACCAGCCCCC A/G TAGTATGCTTTCGGGCACAATAGAATATA SEQ_0587

TCTTCCTGGCTCAGATGATCTGGAGCAG CTAGACTGCAGGGGGCTTGAATAAGTGG

GGTCCACACGGATGAGCTTGGCTGTCAG CTTGACAAAGCACCCGGGGGTCAGCAGT

TCTAGTGGCTTTGTTGTGACAGAGCCTC TCCAGGGGAGGTTAGTTTGATGTCAGGG

AGGTGGCACCAAGGCAGGGCCTGGCGC TCCTGGGCTTTCTCTCTGCCATGACCTTG

TCACTCTGTGCTGTCCTGGGAGGCTGCG GCTGCTTCATGCTCATMGGTGGCTGTC

GGTCCGTGCACACTCCTGGAACTGGTTC GCGTCCTCACGTGACAGTGTGTCTTAGA

ATCTTCATCCCTTGGATATGTCGCCCTTA GCAGGAAGAAAGGGATGTGGTCGTGCC

GGTGGTTGTCCTGAATGGTGGTGCCTCG GTGCCTGTCTC I I I I I I ATCAGGAGATGG

CTCTTCTCTGCTCTGGCCACGGTGCTGT GGATGGGGAT

GTGAGGCCGGGGGTAAGTGAGCTCTGT

GGCCTGCCCCGCACTGTGAGCCTCATTG

TGCTTGCAGGGTTCCCAGTTGCCTGGCC

TCAAGGGCTGCA rs178524 1 1 44054576 CGCGTCCTCACGTGACAGTGTGTCTTAG C/T GTCAAAGTCACACAAAGAGAGGTAGTAA SEQ_0588

AGCAGGAAGAAAGGGATGTGGTCGTGC CCAGTATTTGAACCATGAAAGAGAGATTC

CGTGCCTGTCTC I I I I I IATCAGGAGATG ATTGTAAGGATATAATAGGGAATTTCCTG

GGGATGGGGATGCTGTTTCCCAGAAGAG CCGGTTCCAGAACAATCAATAACAGGAA

GCCCACTTCTATCTTCCTGACCAGAATG CCCTCTAAGCTTCAGTTTCCCTGTCTATA

GACTCATATGCCTGTTTCCAAAATGGTCC AAGTTAGGATATAATAAATAGTACCTCCT ^

CTGGCAAAGGGGACTAAGAAAACCAAGG TCGGAGACTAATTGTCAGGAGCAAATGA g

TTGCCTTAAACCAGATGTGGTTTGTCCCC GATAAAATAGAAACAAATGTTCAGTGCAT

CAGGGACAGGGGAAGGCCCACCTTCCTT TTCCCATCACGTCGTAAATGCTTAGCAAA

AGACATCTTGCTGGTCATACCTGAAGAAA TGTTAGCTGTTAATAATTAGAAAGGGGGC

CTAGTGCTCTCTTAGCATGGAAGGAAATT TGTATTAGTCTGTTCTCATGTGCTAATAA

GGAATGGCTGTTGAGTGGGCAGCCAGC AGACATACCTGAGACTGGGTAATTTATAA

CAGCATTGCCTGCTGCAAGAGCCTGTTG AGGAAAGAGGTTTAATGGATTCACAGTTC

TTTTAAGAATCAGTTGTGGTCAGGGGTTA CACATGGCTGGGGAGGCCTCACAGTCAT

TTGGTTGCAAGGAAAAGAGACCCATTCA GGTGGAAGGTGAATGAGGAGCAAAGTCA

TGGTAACTTAATTAATAATGAGAATATTA CATCTTATATGGCAGCAGGCCAGAGAGG

GTAACATTTATTGACCACGTACTGTGTTC TTGTGTAGGGGAACTCCCCTCTGTAAAA

CAGGGATTAGCCTAAGGCTTTATGCAGA CCATCAGATCTCGTGAGACTTAATTCCCT

GTATTTCATTTAATCCTCACAATACTTCAA ATCACCAGAACAGCACAGGAAAGACCTG

TAAGGTCGGTTCTATGGTTATCTCTATTT CCCCCGTTACTCAATTACTTCCCTCCAGA

TACATATGAGGAGACTAAGACACAGGAG TCCCTCCTATGACGCAGGGGAATTATGG

GTTAACT GAGCTATAATTCAAGATGAGATTTGGGTG

GGGACACAGCCAAACCATATCAGGGGCT

GATCTCAGTGGATCCAAGCTTTCCAAAGT

GTTTTGGGAGTTAAGAGTGCAAGTATGC

CCCAAACGGTCCCCAAAGAAGTTAAAGG

CTTGGAGAGGGACTGGGGACAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs178526 11 44056574 TGATACCCGGTGATTGGGACAGACAGGT AJT ACCAACAAAGGTAACCTACTGGTATTTGG SEQ_0589

AGGGTGGTAGCACAGAATTATTCTGGGA GTATA I I I I I I CTCTGGGCCTTGTCCTCC

GTCAGGCAGAACCCTGCCCAGGGAGGG GCCTTTATCTGATGCTGCAGATGTAATTC

TCTTCCCTTTCAAAACAGACTCTCAGACC TGTGTTCCGCTTGTTTGCTTCATGTTGTG

TCAGTTCACAGAGAATCAACCAGGGAGC TTATGAACATGTCCCCCTCAAATCTCCCT

ATCACTAAAGATACCCCCATCCCTGATCC GGGAGCCTTCCAGCGATCAGCCCCCTTT

ATCTGATTATGATTCAGTGGGTCAAGTAT GACTGTGTGGCTCTGGCCTTGGGGAAG

GGAGTACAGGAGTCTGTGGTTTTACMG

TCTCCCTGGTAGTTTGAGGGGGCAACCT

TGCTCACTGTGGGGGGAGCTGAGGACT

CCCAAAGAAGAGCAGAGACCAGTATTCC

AGTGGTTCCTTTCCAGCCTACTTTTCAAA

AATCTACTTAA I I I I I I I I IACTTCTGTCA

TGAAAGCTATACATACTCACTGTAGGAAT

TTTGAAAGTGCAAAAGGCCAACCCAAAAT

TC rs178527 11 44057422 CCCACTGTGGGCTGCTACTTGCTTGGGC A/G GGAGATCCTTTTCTCCCCTGCAGTGCTT SEQ_0590

CCTTCCTTGGCAGTGGAGCGGGGAAGC CAAAAGCTCCTCTGTCACCTGCTCTGTAT

AGGGATTTGTGGGATGCCCATTCCTCTTT GTGTGGCTTTCTGTTTGAAAAAAACAGAA

ATCTTTCACTCTTTATAACAATAGCTATCA GAAAGAATGGTGTTCTTGGAAAAACAAGT g

ATTAGCGCACACTCTAGGGGCCAGGCAC TTGGTAACCCCGGGCTAGACCCCGGCC W

CATGCTAAGCACTTTATGTGCCTCATACA CCTCTGGATTTCTGATGTATTACCTCCCC

ATCCTCACAACAATGCTATCATACAATCC ACCCTGTGGGACGCATCTGCCCTACACA

TCACAACAACCCTTTATGTGCCTCATACA C

ATCCTCACAACAACCCTCATACAATCCTT

ACAACAATCCTTACAACAATCCTCACAAC

AACCCTACTGATGCTGTTATCACATCCAG

CTCACTGAGCCTTAGAGTGGTCAAGTGA

GGGGTGGATCCAGACTTGAACCTGGGTC

TCTCCGACTCGAGCCCTTGTGCATGACC

TTGCCCCTCCATGGAGGTGCCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs178528 11 44058135 GAGAAGCAGGGACGGTTGGGCTAGATTA A/C TGGATATTTAAATGTTGGGC I I I I I CATTA SEQ_0591

GTGATTTTCAAGTTGTTCTGTGGAATTTC GGTTTACTGTAAGCAAAGCATTTGTGGC

TGAGAACTCCAAGAAGAGGCCTCAGGAT CAAAATACCTTTGGGAACACTTGGAGCA

CCCTTAAGTTAGGGCTGAGTGGATGGCA GATCATCCTCAAGGCACACTGGCCCATG

AATTGGCCTCTTTGCTGTTTCCTTTACCT CCTGTMTCCCAGCACTTTGGGAGGCCA

CCAGAGTCGCTCCAGTTTTATTCATTCAT AGGTGGGAGGATTGCATGAGCCCAGGA

TCATTTACTCATTCATGCTCTCATTCACTC GTTTGAGACCATCCTGGGCAACATAGTG

AGCACCTCTGGAGCCCCTTACACACAGA AGACTCTGTTTCTACGGGAAAGAAAAAG

GTGTGCCAAACACCT AAAGTGGGGACCAGATCATGTGGGTAGT

CTGTGAATCTCACCTTCAGGGGTTCTAAC

AGTTCCGGCTGTTTGTTCAGAACCTTCAG

CCCAGCCAAGCCCTTTCCATTAGCCTTCT

CTTCTTGTCCTCACAAAGCCTTGAGGAGT

TGATGGAGCATGGATTGTGACTCTCATCT

A I I I I I I GGATTAGGAAACTGAGGCACAG

AAAAAAGTGATTGTCCACGATCCTTGGTT

AGTCATTAAAAAAAAAATTATTGAGCATC

GATTTCGTGGCAGGCACTGTGCTAAGTG

CTGGAGATACAACAGTGAACAAGAAAGA

CATAGACCCTTCTTGTGTAGAACTTTAAT g

TTCTAGCCAGAAAAACCATTTTAGCGGCT 4-.

AAATGCACATCCAGCCATTGGATTATGG

CCATCATGAATGCTAAAAGGGAGAGTCC

AGGGAGCTGTGAGAGGATCTGTTTAGGG

TACCTGATTGGCCTGGTCCCAGGGGGAG

TGGTTAGGGAAAGTCTCTTTGATGAGTG

ACATTTGAGCTAGGCTCTAGATCATGGCT

GTGTTCTCATTAAACTTTATTTACAAGAAA

CAGGCAGCAGGCTATGTTTGGCCCGCG

GGCTGTCATTTGCTAACGCCTGCTCTAAA

GGATGCATGGGAATGGGTGGTTCAAAGA

CATGAAACCAGGGCTTGTCCTGGAACCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs178529 11 44058657 GTGCCAAACACCTATGGATATTTAAATGT A/G CAACAGTGAACAAGAAAGACATAGACCC SEQ_0592

TGGGC I I I I I CATTAGGTTTACTGTAAGC TTCTTGTGTAGAACTTTAATTTCTAGCCA

AAAGCATTTGTGGCCAAAATACCTTTGGG GAAAAACCATTTTAGCGGCTAAATGCACA

AACACTTGGAGCAGATCATCCTCAAGGC TCCAGCCATTGGATTATGGCCATCATGAA

ACACTGGCCCATGCCTGTAATCCCAGCA TGCTAAAAGGGAGAGTCCAGGGAGCTGT

CTTTGGGAGGCCAAGGTGGGAGGATTG GAGAGGATCTGTTTAGGGTACCTGATTG

CATGAGCCCAGGAGTTTGAGACCATCCT GCCTGGTCCCAGGGGGAGTGGTTAGGG

GGGCAACATAGTGAGACTCTGTTTCTAC AAAGTCTCTTTGATGAGTGACATTTGAGC

GGGAAAGAAAAAGAAAGTGGGGACCAGA TAGGCTCTAGATCATGGCTGTGTTCTCAT

TCATGTGTGTAGTCTGTGAATCTCACCTT TAAACTTTATTTACAAGAAACAGGCAGCA

CAGGGGTTCTAACAGTTCCGGCTGTTTG GGCTATGTTTGGCCCGCGGGCTGTCATT

TTCAGAACCTTCAGCCCAGCCAAGCCCT TGCTAACCCCTGCTCTAAAGGATGCATG

TTCCATTAGCCTTCTCTTCTTGTCCTCAC GGAATGGGTGGTTCAAAGACATGAAACC

AAAGCCTTGAGGAGTTGATGGAGCATGG AGGGCTTGTCCTGGAACCAAAACTAGAT

ATTGTGACTCTCATCTA I I I I I I GGATTAG TCAACCACCCATCTCTTCATTTGTTCAAC

GAAACTGAGGCACAGAAAAAAGTGATTG CAAACACATGTGGGTTTCCATAGTTCTGT

TCCACGATCCTTGGTTAGTCATTAAAAAA GTTGCCTCTGTTCCCATGCTGTGCTCTCT

AAAATTATTGAGCATCGATTTCGTGGCAG GCAGGCTCCCTGACCCCCAGAGGACCC

GCACTGTGCTAAGTGCTGGAGAT ATGTGATGTGGGC

4-

O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4420249 1 1 44060798 ATTACGAAGGGGAGGTCAAGAAGGGATG A/G AACAGTTCCACCATCCTAAAGAACACCCT SEQJD593

GAAATGCAGTGTTCAATGTAAAGCACCTT GATGCTGTTGATAGTCACATCTCTGATGT

AAACCCAGACACTCAGCCCTGACAGCTC GACTATAAACAGATCTGCAAGCACAGAT

CAGGTCCCACACCCCCTCAGCGCAAAGT CTGTTCTCCATCACTACAGTTTTGCCTTT

CCCCCAGGATAAAGAATCGAACCCAATG TCCAGAATGTCATCGAATTGGAATTATAC

TTTATCTAGTTCTAAAGTTCCAGAGTGAT AGCATGTAATCTTTTGAGGCTAGCTGCTT

GCTCTGTAGTCCCACAGACCAAGGTTCA TCACTCAGCAGGATTCCTTTGAAATTATC

GATCCCAGTGTGGCCAATGACAAGGGGT CCATACTGCCACGGATTTTATTGCAGAGT

GGGTCCTTGGGCAACTTCACCTCTCTGA AGTGTTCCATTGAGTGGATGGGCCATGG

TCCTCATTGTTTGTACTGAC I I I I I GTCG TTTGTGCATCCACACATCTGTGGAAGGA

TTGTCATACAGTTCTATGAATTCTAATACA CATTTGGGTTGTTCCAGTTATGGGTGATT

TGTGTACATTTATGTAACCACCACCATAG ATGAATAAAGCAGCAGTTATGGGTGATG

TCAGGATGCT ATGAATAAAGCAGAGG I I I I I GGGTGAC

CATCAAGGTCAATATCTAGGAGTAGGATT

GTTGAATCACTTGGCAAGTGTATGTTTAA

CTTTATAAGAAACTGCTGAATTCTTTTCC

AAAGTGGCTGAACTACTTACACTCCTACC

AGCAGTGTATGAGACTTCCAGCTGCTCC

TTATCTTTGTCAACACTTGATGTTGTCAC

TA I I I I I AAAACTTTTAGCTACTATAGTGA 4--

GTGGGGTAGTATCTGGTCCTCATTTTCCT ^®

CATCTGTAAAATMTAAGGAAAATATAAG

AATTCTTGCTTCCTAGGATTCTGGAGTGA

ATGAGATGATACAGCAGGTGCATTTGCT

AGGCTCAGTAAATGGCGGCATTTAAAGG

TAACCTTTGCTATTTAAACTCACTATTTGA

ATCTAGGAACAGAATAGATTCACAGCAA

GAGAGATACTTCCTTTAAAACAATTTTCC

TTAGAAGCTTCTGCTG I I I I I I GTTGTTG

TTAAAGACAAGGTCTTACTCTGTCACCCG

AGCTGGAGTGTAGTGGTATGATGAAGGC

TCACTGTAGCCTCAACCTCACAGGTTCAA

Supplementary Table 3

SNP Cjhr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1075983 1 1 44063971 ACAGGGTTTCACCATGTTGGCCAGGCTG A/G TTTTCTTTCTCATCTTTCTGTGCTACATTC SEQ_0594

GTCTCAAACTCCTGACCTCAAGTGATCCA AGGGTAATTTGTTTTGGTCTA I I I I I CAG CCTGACTTGGCCTCCCAAAGTGCTGGGA TTTAATAATTCTTTCTTTAGCTGGATGTAA TTATGGGCATGAGCTACCTCACCTGGCC TCTGCTTTAATCTATTTGAGTΠTAAATTT TGCTCTA I I I I I GAAAGAATTTCACTGGG AAGCAAATATATTTTTATTAGTAGAAGTTC TGTAGGATTACAGGTTAATAGTTATTTTC TAAAAGTTATTCTTTATACCTCAAGTTTGT TGACTTCCATTGTCCCTGTCAAGTAGTCA TTTTCA I I I I I I AAGATGTAATAAGCATAA GCTGTCAGTCTGTGGCTTCTTCAAAGGT TAATAATAATAAGTTTA I I I I I I GAGACAG GATCTGTTTCCTCTGTCTCAATGCCTTTA AGTCTCACTCTGTTGCCCAGGCTGGAAT AGACATACTCTGATCATTGATGTTATACA GGTGAAGTGCAGTGGCATGATCTCAGCT GTGTTACTATTATATATCTCGATGGTTTCT CAGTACAACCTCTGTCTCCCAGGTTCAA TTTTACTGATCTTATTTTGGGTATTGGGA GCGATTCTCCTGCCTCAGCCTCTAAAGT TTCTTGCATCTGTGGATTCTTTCAGCAGC AGGTAGGATTACAGGTGTGCACCACCAC TCTGGAAAGTTCTCATCAAATATTTCTTCT ACCTGGCTAA I I I I I GGCA I I I I I AGTAG GCCTCATTCTCCCTCTTCTCTCCCTCTGG AGATGAGGTTTTGCCATGTTGGCCAGGC AATTCCTATTAAATGTATGATATAGATCAA TGGTCTCAAACTCCTGGCCTTAAGTGGT CTTGCTCTGTCTTCATGTCTCCTAATCTC CCACTTGCCTCAGACTCCGAAAGTGCTG TTTTTCAT GGATTACA rs10838231 11 44069549 GGCTTTAGG I M I ! GTTGTTGAGAAGTCT A/G TTCTGCATTGTGAGTTTACATTTGTCAGG SEQ_0595

GCTATTAGTCTCATTGTTAGTTCATTGCA GTTTTATTTGTCAGAATCCTAGGTAGCTT GGTGATCATCTCTGCTCAATTTTGGAAAA GTGTTGAGGATGTGGGTCTCCAGAGGG O TTCTTAGCTATCATCTCCTTGGATATTAC GATTTATGTTTCCTTCTGTTGGATGTCTTT CTTCACCTCCTTTTCTCTATTCCCTCCTTT GGGTGCTACCAACCTGGGAATACTGTAT TAGATATGTGCCATTTTCTTCATCTCTCC GTTACTATCCTGGCTTGGAGCTTCCTAGA TCTCCCTCTCTTAACTTCTCTTTCCTATAT CCATGCTGGTGGTATAAATTCAAACCCCA TTAATTCGTTTCCTGTCTTTCAGATCGAT GATGGTCATAAAGCTTGATTGCTATGAAC CGTTGTTGTTTCTAACCTACTATTTAACTT TGAATGTTCATCCCCTCCCACACCTCCTT ATGCATTGACTTTTCAATTTCAATGTTTAT CATATGTTGAAGTCCTAATCCCCAGTGTG ATTTAGTACATTTTCAGTCTCCTTGGTCTT ATGATTATTGGAGGTGGGGCCTTTGGGA TTAAAAATATAACATCTTATTTCTTTGTAA TGTAATTAGGTCTTGAGGGTGGAATCCT TGTTTTACATTTCATTTTAAGTCTTTGAGT CATGAGTAGGATTAGTGCCCTGACAAGA GGTATAAACATACTTGTTTTATATTTATGT AGAGACACAGAAAGGTCΓΠTTCTCCACC ATCATAATTCAATTATATGTAGTTCTTGG ATATGAGAATATAGCAAGAAGGTAACCCT GGGTTAAATTTCTGCTGTTTGTGATTTCT CTGCAAACCAGAAAAAGAGCCCTCATCA GGTGGTTTGTTTTCTCATATGCTTTATA GGAACCAAATTGGCCAGCACCTTGATCT TGGACTTCCTAGCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs3814767 1 1 44072318 AGGATTAATTAAAAACATACATGTTTAAAA A/G GGTGTGTGCTACATTTTGTATCATTTGCA SEQ_0596

TACAGATAAATATGGAGAAGAAAAAAAGA GGGGGGATTTGATTTGGAAAGCAGAGCA GGCCACAATCTTCCAGACCAGATAGCTA ATGCCCCCTTGGATGTGGGGAAGCAGAA TTGTTGACTTATTTCAAAAAGTGAAAACA CATGAGTGTCCCATCCCCAGAATGTCCT ATATTCCCTGGGATAAGATAAATTTGGAT CATCCCAATCTCCCTAGATCTGTGACAAG ACAGTTCCAGTGGTGATTGTCACTGCTCT CAGGCATTAACTCACAAAAATATCCCTGG CCACCCATCCAGTTCTCAAATGGGGT AATCGAGGTTGCTGCCGGAAGCCTCTGT A rs7928476 11 44077382 ATTCAGAGTCTATGGAAATATCTAGCCAT G/T TTCACTGCAAGCTCCGCCTCCCAGGTTC SEQ_0597

TCCCCCTCCTCCTTTGGAAATTCCTTCCT ATGCCATTCTCCTGCCTCAGCCTCCTGA ATTTAGGAAAGATAATAGTCAGAGGCCG GTAGCTGGGACTACAGGCACCCACCACC TCACATATAATAACTCAAAACTTGGATGC ATGccTGGCTAAi I I I I I GTGTΠTTAGTA TAAACCGTGTGCACCTATGGAACTGGGA GAGATGGGGTTTCACTGTGTTAGCCAGG AGGATACAGACATTTGTTCGTTCAACAAA ATGGTCTCGATCTCCTGATCTTGTGATTC TATTTATGTTTATATTAAATATGTTCTATTT GCCCGCCTCCACCTCCCAAAGTGCTGGG TC I I I I I I CTCCTTGGAGACAGGGTCTCC ATTACAGGTGTGAGCCACTGTGCCTGGC ATTGTCGCCCAGACTGGAGTACAGTGAC TTAA I I I I IATA I I I I I I AGTAGAGACAGG GCAGTCATGGCTCACTGCAGCCTCAACC GTCTCGCTATGTTGCCCAGGCTGGTCTC TCCCGGGTTCAAGAAACCCTCCCACCTC AAACTGCTGAACTCAAGTGATTCTTCCGC AGCCTCCCAAGTAGCTGGGAGTGTAGTC CTCAGCCTCCCAAAGTGCTGGGATTACA GTGCACCACCACACCTGGCTAA I I I I I G GGTGTGAGCCACTGCGTCTGGCTTAAAT O 00 GG I I I I I I I I I GTTTGTTTGTTCG I I I I I G ATATGCTCTGGATTTGGTATTAGATGCTA AGACGGAGTCTCGCACTTTCATCCAGGC GGAATACTGAGCAGAGATGAACAACTGA TAGACTGCAGTGGCGCGATCTCG TTACAGGAAAAATCACAACCAGTAGAGG

AGACAGACTTGCAAATACTTAACCAATTC

ATAAAATGTGGCAAGTGCTAGAATGCAG

TGTATGAAAGGTGATGTGGGTGCTCACA

GGGAAGATCCTCTCTCTGTAAAGCA rs7935138 11 44099510 TTCAAGCCCTAGTGGGGTGGGAGCTTCT CfT GTGCATATTGAAAACCATGCATTCATCTC SEQJ3598

GCTTAAGAGAAGAGTAGTAAGGTAGCCT AGTATCTCCAGTTCCATCCAACACTGCAG GGTGCTACCACATTTATGTTGAAAATGGA GGGCATTCTGGTTTTCTCTCTTTCCATAT GTAGCAGTAGAGCGGGGATCCAGTGATC TTGTAACTCCCTTCTCTGACTCCTAGAAA CTGGTAACTGAATGTCTAAAATAGAACTT TCTGGCTCTCTTTATCCTCAACATCTTTA TATTTCTCATCAGTGAAATCTAACCCAGA CTTATTTGATCAACCCTCTTATATTCATCA GTCTTTCTTAAGAGTTTTCTTTGAGCACC AACTTCTGTTGCCCCCCTGCCCCCACAC ACACATCAACATCTGTATTTATTTCTGTAT TGCACAGAGGCCTTCCCCACCCCTCCTC CTGTACAGACAGATGTCTATCTATT ATCCCTGCTCAGACTCTGACCCCCTACA TTGTGCTGCCCTGCACCCTCCCAGCACA GATGCCTTTCTCACACTTCTTGGGTTCTA GCACTGGGGTGATGCTATCATTACCATC ATTCTCCCCACAACTTGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11037880 1 1 44107557 TAGATCTGCTTGGGTAGTGCTAATTATGG A/G CCTCCTTGCTGTTCCTGGAACTTGCCCA SEQ_0599

ATTTAAAGTCAGAAGGCCTAGGTTGAGAT CCATACTGCTTCTTCAGGGCTGTTTGCTT

AACCAGCTCTCTCACTGGCTGGC I I I I I G GTTAGAC I I I I I GCCTGGAATGCTGTTTC

ATCTTGGCAAATGACTTAATC I T I I I I GA CCAGGCATTCTTCTGGCCTGCTTACTCTC

GTCTCAGTTCTCCCATCTGTATAGTGGAA TTGCCTTCCTTGTCTAATTAATTCACTGTT

ATCATTTACTTACTTAACAAATGTTTATCA GGGTTAGCACATAATAGGGCTTCCATAA

AGTGCTAACTGTGCAAGGCAGTAATATA ATATATGCCAGATAAATGAATAGATTTGC

CCAGGTGCTGAGGATACGCTGGTGAGTG ATAGATAGCTAAAGGAGAAAAGTATTTGT

GAGCCAGGCACACΓΓTCCGTCCTAATGG TAACTTAGAAACGGAATAAAGGAAGAGT

ACTAGCCTAGTTGGCAGAAGTGAGGTTT GTACTAGGTGGGTGGGATTTCACATGCA

AGAGTTTAATCATTAATTTATACAAATGTA AAGGCCCTCTGGTAGGGCAGAGCATGGT

ATTACAAACTCTGCCAAATGTCGTGAAGG GTGTTCAAGTGACTGAAATAATACCAGTG

AAAAGTGATTGTTGAGTCCTCTCTTTCTC TGGCTAGAGCACACTAGTGGAGTGGAGG

TTACCCACCACATCTAATCTGTTAGCAAA CAGGGTGAAAGATTAATGGAGTAGGGAG

CCCTGTGGGCTCTACCCTCTCATCCCCA TGGGAGGTAAAAAAATGGAGCTGTAAGA

TCATCAAGTCTTCCCTCATCTGCATCTCT GAACTCCTTTGAGAAGTTCAGCCAGTGA

TGCCTGGCTTTTGCAGTGTTCTCCAGTTG AGAAGGGAGGGGAAAGAGATAATACTTA

TTCTCTCTGCTCCTGTCCTTGCTTTCCTG CCGGAAGGGATGTGGGGCTGAAGGAGG

TAGTTTATTCTAACACTTTAGATAGAATGA TTTGGGATGTTGTTTCTGCTT

TCCTGTTGGAACATGGTTAGGTTATATCA £

TGCTTTTGCCCAAAACCCTCTCATGGCTT ^

GCCATCTCAGAAAAAAAGCACAAGTCTTT

CAGTGGCCTACAAGGTCCTATACTCTTTG

CTGTGACTCTGTCTGTCCCATTTCTTCTT

TCCTGGTGTTATTCTCTGCCTTCTTTACT

CTGCTCCAGCCACAATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11037882 11 44108153 CTTCTGGCCTGCTTACTCTCTTGCCTTCC A/T TTTGCTGTTGTCTCCAGAGCATCTGTGGT SEQ_0600

TTGTCTAATTAATTCACTGTTGGGTTAGC TGTACCAGAAGAAAAGATGTCAGATGTG

ACATAATAGGGCTTCCATAAATATATGCC TACAGTATTTTGCAGAGCATCCCCCAAAG

AGATAAATGAATAGATTTGCATAGATAGC ACAGATTGAAGAAATGCAGAGACAGGTA

TAAAGGAGAAAAGTATTTGTTAACTTAGA AGAGGCCAAGTCTTGGGGAGGTGACATG

AACGGAATAAAGGAAGAGTGTACTAGGT GGTGGTACCGAAATGGTGGCCTTGACTG

GGGTGGGATTTCACATGCAAAGGCCCTC GATACAGAGGGACAGGAGCTGAATGCCT

TGGTAGGGCAGAGCATGGTGTGTTCAAG GA

TGACTGAAATAATACCAGTGTGGCTAGA

GCACACTAGTGGAGTGGAGGCAGGGTG

AAAGATTAATGGAGTAGGGAGTGGGAGG

TAAAAAAATGGAGCTGTAAGAGAACTCCT

TTGAGAAGTTCAGCCAGTGAAGAAGGGA

GGGGAAAGAGATAATACTTACCGGAAGG

GATGTGGGGCTGAAGGAGGTTTGGGAT

GTTGTTTCTGCTTGTGAAATGAAACAAGA

CTGTGTGTAGAAATGCTTTCTGTGAAGG

GCTGTGTGTATGTAAACTG rs7117287 11 44109582 CAAAATCACCGATGTGGGAGAAGAGCAG C/T TCTGGGCCTCAGTGACCTCATCTGTGCA SEQ_0601 ^

GAAAAGAGGCTTGGCGGATTCTCAGCAG ATATTTTGGCATTCTGGTTTGAACGCAAA S

TACGTGCGTAAGTGTCCCATGCCACCCC TCGCAGGTTAGTTTTAGCTTCCCTGCAGT

CTGCTGTTAGTTCGGCACCCTCAGCCTC TTATTTATAGCATCCTCCTGTTCGTTTTAA

AGGCAGAGAGCCTGCATTTGGCCATGTC GTTTCTGGGTTTCCCAATTGTTATTTAAC

CCAAGAACAGGCCACAGGCTTCTGTCTG CACTGATTTCATCTAAGTTTTAGTGAATC

GATGGGGACAGCGCATCTGCCTGGCTGT AGAAAATCAGTCCAGAGATCTCTAGA

GTGGGGAGGGGATCTGAGGTTCTGACT GTTACTTAAAGTTTCACTTTGACCTCCTG CTTGAACCCCACTCTTCCCCTGACTTGG GGCTCTGCAGTGTGACTCAGG I I I I ! CT CAGCTGATTTAGGAGGCAGCTCTCTTGA GTCTATAGCATCAGTTACCACTTCTTCCT TTACTTTTCAGCTTCCACATTCTGATGCT

GTTATCTTGTCTTTCATTCTC I I I I I CTTA

GGGGATACATACCTTAATTTAGAAAATTC

CCCTTAATTGTCATTTTAGAGTTTTAGGA

GAGTGAGGTTAGTGGATGTGTTCAGTCC

ACCCTCTTTATTATGATAGTGAACTTCTTA

TCGACACAGATTAAGTCTGTAGGTTCTTA

CCTCAGATTGCCTGGCTTGGGTATCAGC

TCTGTGGGTTACAAACTCTGTACCCTTAG

GTAAGGATCTGCCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs11600929 11 44111859 AGCAGAGGTCTCCATCCACTTTTAATTAA A/G CAATAGAGCTAAAGTTTCTGATTTGGCCC

CTCATTTTCCCTCTGAGTATTTAAATCTTT CAGAAATGTGGGGTAGGGTCTTGGTGAG CCAAGAAATCCTAAATGCCATGAGCCAC GAAGGTATTGGAGCAACATTTTGCAGCTT TCTGGTGCTTCACACTGACATCTTCCTGA AGAGTTTAGGATCAGAAAGGCTACAATCT TAGCTGCTCTCTAGAGACCATTTCTTTCA GACAGATGTCTAAAGTGGTGAAAGTCCT GATGAAGAAGAAGAAAGAAAATCCTGCT TGTTGTGACGGGAATTTGTGTGTACCAA TAGCACAGGATTTTACTCTCCCTAGAT GGGAGAAAGTCATACTACCTGACAAAGA A rs11600984 1 1 44112201 CTTGTTGTGACGGGAATTTGTGTGTACCA A/G GCCACCAGTGAGCAGTGCTGCCACACGT SEQ_0603

AGGGAGAAAGTCATACTACCTGACAAAG GGCATTGGGCAGACTACTGGGGGCTTAT AAAGGAAATTAAATTCCCTTAGATGTGAT AGGGCTTTTTGTGGGGAAGTTAAAAAAC AGTAGCAGCCAAAAAGTTAACTACAAGG AGTTCCTTAAGTCAGTAGAAGACAGTAGT CTAGAGCCTAATGTAAGTAACAGCTATAG TGTAACAGTATAAAGCTGACTTCTCAGTT TTAGACTAAGACTTTTGAAAAAAAGTACA GGCCTTTTATTGTCCTGTGAGCTAATGAT ACCTGTGTCTCTGGTATCTATTCCTGAA TAACTAGTTAATTTATTGAATCCCTAATG rs4379834 1 1 441 15014 ATTTTATGCTGCTTTAAACAACACATGTT OT GTCTACTTCACAGGAAGAACTCCAGGGA SEQ_0604

GACCACTTTCCTTCACAATAGGGATATAC TCAGGTCAATGTGCACTGTTTAAGGGAA ATACTAGGAAAATTCAAACAGAATATAGA GCAGCCAGTAACTGTΓTAAGGGCAAGTA GTGCTACTGAAAAAAAAAAACTGTGAAAT CAAAAGCAGAGACCACGAAACACAGCTT TTAAAATATCCCACAAAATGATTACACCC GGAGTGGCATGTCAGGACTGGAGAGGG ATTACCAAGGCTCTCCCATTGGCCAAAG GAGGAGGAGGGGCAGGGAATATTTGGC AGCCTCCCTTTGTATTAGAACCATGGT A I I I I I IAAAAAGCCCCAAGAGTCCAGTT

TATGT rs 10838240 11 44119149 I N I I GGCACAAACATGTTA I I I I I CCTTT CfT GTGTAGCTGTTGTGGGGAAGAGTACAGT SEQ_0605

TTCAAGTGGACATGAGCAGTTTTGCAAGT CATCCCTCAGTATCTGTGGGGGATTGGT GTGTTCCATTTAAAATAGTCATTTAACTTG TCCAGGACCTCCTGCAGATACCAGAACT AGGTTGAGGCAAAAGCAAGAATTTTTATA CAAGGATGCTCAAGTCTCTGCTACAAAAT GTAAGTTAGTCAAACATATATAGCTGTTG GGCATAGTATTTGCATATGACCTATGTAT ATCTTGGATTGTCATTGAACAAATAATAA ATCCTCCCTTATACTTTAAATTACCCCTA AATATACTGATTCATTTTATTACT GATTAATTATACTTCCTAATACAATGTAAA

TGCTGTGCAGATAGTTATTATACTGTATT

GTTTAGGGAATAAGTGAAAGGAAGAAAA

TTTTATGTATGTTCAGTACAGGCACAGTT

I I I I I I CCGAATA I I I I I GATCTGTGATTG

GTTGAATCCATGGATGTGGAACCACAGA

TACAGAACCGCAAATACAAGGGACCAAC

TGTAATTGTACAAAAACCAAATGAGCAGC

AAAACAAAGCAAAATGCCCCAAACTCCAA

AGTGGTAGAATCACTTTTCCATACTTTTC

TGATGACTAAGTTGATATCATCTAATTAG

TTAAGTTTAAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs7118541 11 44127521 GGGGTATTTGTCTTTTACACTGAGGTAM A/1 TTTGCCTCTCTTTGTCCCATGTTCTATTTC SEQ_0606

TACA I I I I I I I GGGAAATTCCTGTGTTGA I I I I I I CTGTATCCTTTCTCTGATGATAAC AGATTGTTTCTAGGTTGCTTGTCCTGCCT TAGG I I I I I AAACTCTTTATAGGAATCAA TTTTGTAATGTTTTCCTTCTAATTGCAAGT CCATGTAATCCAATGCCATATAAGCTTGT TTACTTGTCTTATTCCAAACTCCATGGCA AAAGAGCTTGTAAATACGTATTGGACCTT TGACTTAGAGAAAGAAAAGAGTTTGGGG GAAAATAAAACCTTGTCTAAAAACTCTTG TTGGGTGCAGTAGCTCAGGCCTGTAATC TGAACTTACATGAGTACACTATTT CCAGCACTTTGGGAGGTGGAGGCAACA GGATCACTTGGGCCCAGGAGCTCAAAAC CAGCCTGGGCAACACAGCAAGGCCCCAT

CTCTACAGAAAATGAAAAACTTAGCTGGG

TGTGGTGGTGCATGCCTGTAGTCTCAGC

TACTCGAGAGGCTGAGGTGGGAAGATTG

CTTGAACCTGGGAGATGTAGGCTGTAGT

GATCTGTGATCATGCCACTGCACTTCAG

GCAGGGTGACAGAGCAAGACTCTGTCTT

AAAAACAGTTGGAGΓΓTGGAATCCCCA IT

TTTC rs4551754 11 44128032 AAAAGTTTTAATATTAACAAACACAATTAT A/G TCCAAAACTATGAGTCACTCAAAGGTTAG SEQ_0607

GAAACTCTGTGCCATACTAAATGGACCTT AAAAACAAGAAAATACATGGACCAGCACT ATTTCTCTCTCTCTCGCCCTTCTCAGGAT CAAATCCTAATCTCAAACACAGTGGCCTG TTTGACAACTTGCTCATGACCTTACCCCT GAACATTCCCAAAGGCCCATATATAAGCA TGGTTAGCTGCAAAGATCTTGCTTGTTTA CATGTCATCCATTTCGAAGCATATTACTT AATCTAACTTTCTCCACTCCTAGCA I I I I I CCTTTCATCTCCAGTCTCAGTATTTATATT GTTAACCATCTCTTAACCTCCTCCAGTTT TGTGGGGGGTAATTAAAGAATTAACATG AATCCCATTTCCCTGGTGCTGAGGAAAA CAGTTAAGTTCCACCAGAGAAAATGGCT AAAAGGCTCTACACAATCTTCCAGGCCAT AAAGCATATATTCGTTAATGACAAAAATG GTTTCCCTAGCATGTTCCAAAGAATTTCT TAGGGAAGAGGTCTAAATGATGAAGTCC GAAGAACTCTCAACATCAGCAGCAGCCC AGGACAATACTTTCTGATATCAAAATAGT CATCCACATATAAAAAGTTGAATATACAA GTACTCATGTAAGTTCACAAGAG I I I I I A CAATTTCCTCTTTGTGTAGTTTAATTTTGG GACAAGGTTTTATTTTCAAGGTCCAATAC GGAGTTCTAAATCTATTATTAC GTATTTACAAGCTCTTTACAAGCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

RS 12223543 11 44142492 TTTGCTGTTTTCTCATTAATTTTGGAAAAT CfT GTCAGTGGGCTGTTTTCTCTTATTTCAAA SEQ_0608

TCTTAGCTC I I I I I CCTTTAAATACATCTG AAACTGAGAGGTTAAGTAACTTAAAATTG CTGCCTTGTTCTCCACTTCCCCCTCTCTC CTCAAGATGCTCTATAACTGTTGTTCTTT CTCTTCTGAGACTATAGTTACACTATATT CCACTATGCCACACTGGCTTCTCTTAAAT AGAGTGTTTGATATCGTCCTACAGTTCTA ACTTATTATTGCTAATCCCATTGCCTTTG GAGTACTCTGTTTTAGA I I I I I CCCTCCC CATTACTGAAAATTAAGAAATTAATCACAT ACTC I I I I L I C I I I I I GTGTTTCAGTTTGG TTAATTTATGTATAAACTGAGATAGCAGT ATAATTTCTATTGTTCTGTCTTCAAGCTCT TTCAATTTGGAGTTCCATTTT CTCTTTCTTTTCTTGGCTCTGTCTAGTGT GCTAAGACTGTCAAAGGAATTCTTCATCT ATAATACTGGTΠTTCACTTCTAGCATTTT

TATTTGACTG I I I I I I ATATTATCCATCTT

TCTACCAAAAATTCCCATATGTTCCTGCG

AGTTGTCCACC I I I I I CACTAGATCCTTT

AATATATTAATTATAGTTAAAGTCCTTGTC

TAATAGTTCCTTCATCTTGGTCATCTTTG

AGTTAGGTTCTGTTGACAGCTTTATTTTA

ΓS7120534 11 44143978 GAGCATAAGGCTTTGGAATGCTTAAGTT C/T GTGCTGGTGCTCTTAATGCTCTGGAATG SEQ_0609

GGAATGTGGTTTAATTTGAATATGACTTA GGGTAGAAAAAAGGTCTGAATTTAGTTAG W AAAGAATATATGATGATAGACCCAGTTGG GAGTCATGGATTTGGATTGTGATTCTGCT GTAGAAAAGGAGATAAATATTCAGGATAT CCTTAATATCTTTGTATCTTAGTTTCCTCA ATATGTGTTTATGTTTGGCCTGATGCTTT TTTATAAAATGAAACTGTCCCAAATAAGT GTAAA I I I I I ACACCTTTCAGTTTCTTGAA GACAAGCTGGTTGTGAAGAGCAGATGAA AAAGGGTGATTTTCTAAAACTTGCTA ATAATGAATATAAAAGTGCTCTGCAGCAG GTAGAACACTAACATTTGCAAGGATGCT GA I l I I I AAAATACCAGTATCTATTTCCAA GGAACTCACAGTCTAGCTGGAGAGAAAA AAGTAATCCTCTGAAACA

Supplementary Table 3

SNP Chf Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs10838241 11 44146150 CTGACAGGACCTCTGACAGGATtAAAGT A/G AGTGTTCTCGTAGTTCAATTCCCACCTAT SEQ_0610

GGCCTGACTGTACTCTTACACCTGCCAA GAGTGAGAATATGCGGTGTTTGG I I I I I I

AAGAATAAGTTACAGTCTTAGGAGGAAG TTTCTTGCGATAGTTTACTGAGAATGATG

ATAATCTGAATCATCCAGAACCTCTACAG GTTTCCAGTTTCAACAAAGATATGAAATC

GTTTTAAACAGAATGTCTGCCATCCAATA TACTTTTGACAAGATCAAATGGAAATTCT

AAAAATTAAGAAGTGTGCTAAAATTGAGA GGAACTGAAAAATATAGGAATGAAATTAA

CCAAATGACCAAAATGAAGAGAAAAACG GAATTTAATACATGGGTTTAATAGCAGTT

ACAGTAGAAAGATATCTACAGGTGACTCA TAAACACCAAAGAAAAAGGGCTAGAAGA

GATATTGGAGTTTATCAGTCAAAAACTGA TTATTGAACCAGAAGAAAAGTTAGTAGAA

TTATGTTCAAGAAAGTAGAAGAAAAGAAG AACACCCAGATTGAAGCACAGAGAGAAA

GAGACTTTC I I I I I I I IATTATTATTATACT AAATACTGAAAAGAGAATAAGAGATACAT

TTAAGTTTTAGGGTACATGTGCACAGTGT GAGATATATTGAAAACATTATGAAATATAT

GCAGGTTAGTTACATATGTATACGTGTGC TTCACATATATTTATATTTGGAGTCTCAGA

CATGCTGGTGCGCTGCACCCACTAACTC AGAGGAGAGTGCAACAGAAATAATATTTA

GTCCTCTAGCATTAGGTATATCTCCCAAT AGAAATATTGTCCGAAAGTTTTCTAAAAT

GCTATCCCTCCCCCCTCCCCACTCCCCC CAGTGGAAAGCATCAAACCACAAATTGA

GACCCCACAACAGTCCCCAGAGTGTGAT AGAAGCGCTACAATCCTCAGTGGGATAA

GTTCCCCTTCCTTAGTCC ATACAAAGGGCCACACCTAGGCATGTCA

TAGTTGAATTACTGTAAGCCAAAGACAGA £

GAAAGCTTAAATGCAGTCAGAAATAAAAA E

GCATATTGTCTTCAAAGGTGCACCAGTAA

GATTGTCAGCTGATTTATTAATGAAAAAT

TGGATGAAGCCAGAACACAGTAGAAGTA

TATCTTGAATGTTCTGAAAGAAAATTGCT

AACCTAGAATTCTCTACCTATCAAAAGTA

TCCTTCAAAAATTATTTGGGTAAAAAGAA

GCTTTCAAACAAATAAAAGAGTCACCCAC

GAATTCTACAGTGAAATAMTAACAAAAT

AAATTCTTCAATTAGCAGGAAGATGATAT

GTGATGGAAGTTCAGATATGCATTAAGAA

AAGAAAGGGTAAATATACGGTGAAAATTT

ACTTTAAAAAATAATGATGTCCCCAGACG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs871504 11 44156870 AAAATATCACTCAGCTATAAACACTAACA C/G CAGGAGGCCTTCTTGGCTTATTCTCTCCA SEQ_0611

AGCAATAAATCACTCTGCAAGCTGAAGAA TCTTCCTCCTACTGCCTAGATATGATTAA GCACTAGCTCGGATGTATGAAGCAGAAC AAAAAAAAATGTATGGAATTTAGAAATTTT TCTAAGTTGAAAAGATACCAGGTTAACAG AGCTTGAATTTAAGGTAAGTTTAAGCTTT TCTGTGTAACTCAACTCAGCACCCTGTAA TTGAAGTCTATTGTTTTTATAGGTATCACA GTTGTGGAATGTTTCTCTGGAATTTGAAA TTTATAGGATCACATTTGCACAAGTGATC GCCTACCCTGCCCC CAGTATGCTACCCTAAATTCCAGACCTTT CCTTGAGTAGTACCTTTTACTTCTTTGGA AGTGAGCTAGAAAGTCTCAGGATGTCAG CAGCCAGGGAATAAGGAAAGCTGAACTG GGTCTGCAGATGGAGAGATGCAGAAAGA CACAGAGAGCTTGATCTGGGGCCCCAAG CAAAGAACTTGGCCAATTCTGATGGTCA GATAGAAAATGGTAAAGAAAATGAAAATC ACAAGCCAGATCCAGATGGGGAGGATAG ATAAAGCATTTGAAAAGACCGACTCGAG GATATTGCTAAGATGATCTTGGCMTCAA AAGAGCATACTAGAGCTTT rs903513 11 44156927 ACAAGCAATAAATCACTCTGCAAGCTGAA A/T AAAAAAAAAAATGTATGGAATTTAGAAAT SEQ 0612

GAAGCACTAGCTCGGATGTATGAAGCAG TTTAGCTTGAATTTAAGGTAAGTTTAAGC AACTCTAAGTTGAAAAGATACCAGGTTAA I I I I I GAAGTCTATTG I I I I I ATAGGTATC CAGTCTGTGTAACTCAACTCAGCACCCT ACATTTATAGGATCACATTTGCACAAGTG GTAAGTTGTGGAATGTTTCTCTGGAATTT ATCCAGTATGCTACCCTAAATTCCAGACC GAAAGCCTACCCTGCCCCCCAGGAGGC TTTCCTTGAGTAGTACCTTTTACTTCTTTG CTTCTTGGCTTATTCTCTCCATCTTCCTC GAAGTGAGCTAGAAAGTCTCAGGATGTC CTACTGCCTAGATATGATT AGCAGCCAGGGAATAAGGAAAGCTGAAC TGGGTCTGCAGATGGAGAGATGCAGAAA GACACAGAGAGCTTGATCTGGGGCCCCA GCAAAGAACTTGGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs10838244 11 44162378 I I I I I I GAGGGTGATTTGTC I I I I IAAACC C/G CTGTTCCAGGGAATTTTAT I I I I I CATGTA

TGAAGATTGTTGAGTTTAAAGGTTCTTCT TCATGATATTTACGCTGGGAAGCCTTGTT TTAATCCA I I I I I GGAAAGTTTTCATTCTC TTCCCATGTTATAGAGCATTCTTGGTTTA

TCTTTGAATATTACATATCTGCAATTCTCA ATAAAACTAGCTAAAAATTACA I I I I I I CT CTAATCTTTCCTTCTAGAATTCTATTAAAT TAAAGTAAGTGCTCTTTCCACGTGAGAAC CTTTGTTAGGCCTΠTATTCTGTCCTTAC TAC I I I I I I I I GTTTGGTTTGAAGGTAAGA CTTATGTCTCTCAGCTTTGTTTTGTTTCGT AAGGGAGGAGGAACTTTTCTCTT

TCATCAGGTTTTCCACA I I I I I CTCTCTCT

GTGCTGCATGCTAGATAAC I I I I I CACAT

CTATTTTCCTATTTTCTTCATCTTTGACTA

ATGTG I I I I I IACCCATTCATCATGATTTA

AATTTCAGTGGTTATTTGTAGAAGTTCTA

TTTGATTATTTTTCAAATCTGTCTGCCTG

GCCTTCTTCATAGCATC I I I I I I I CTCACA

I I I I I AATTCCTTCTTTTATATCTTTAATCA

TTTGAGACACTTACTTTATATTCTTCATCC

AATTTTCTGAATTCCTGTGAGGTCTGATC

TTGTCATTTGTCTACTGTCCACTGCTCTT

GTTGCATTGTTTCCTTAGATGTTTTATAAT

TTTGGAATGTGAGTTCATCTCACATGTGA c

\

GGTΠTCTGTGGAAATTCTCCCATCCTGG

GATAAGGAGGTATTTTCCAGAGAATTTGT

TTTTGTTTATTTTGCTTCTTCAACATTAAT

GTCTCACTGGAGGTTTCTGAACCACTCA

GATAATTCATTGAAACCCCAAACCTGCAT

GAGCCCCAGCCTCTGTTAAAAGCTCCCA

AGGGAAACAGAGCTGACTTGGTTACGM

GCAGTAAGCTCTTTCTCTTTCTGCAAGTT

GGTGAAAACAT

Supplementary Table 3

SNP Chr Position 5¹ Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12792891 1 1 44167904 TTGATTTTCTCCA I I I I I CACATGTCTGTT A/G TAGACATGTGCATCAGGTAAACTTCAGAC SEQ_0614

TAATGGTTGGTCAGTGAGATTTGGCCTTC TTGTCCCCAAAACTTTTCTCTCTTGAGCT

AGTGTTATTCTTGTTTTTCAGAACAGTCA AAGAGATGCTACTTGAAGACATTGTTAGG

GTTATTGTATTAGTCTGTTCTCACATCAC TCTCAGTAATTCTCTAGTTTTGCAAGTCA

TGTAGAGAATTACCTGAGACTGGATAATT GCATGTGCCTGGCTGGTGGAGTGCTGTG

TAGAAAGAAAAGAGGTTTAATTGGCTCTT CTGTGGGTATTTGGGGCTGTAGAGGTTT

GTTTCTGCAGGCTGTACAGGCTTCTGCT AATGGTTAAGGCAACATGGACCACATTA

TCTGGGGAAGCCACAGGAAACTTACAAT

CATGGCGGAAGGCAAAAGGGAAGCTGG

CATGTCTTACATAGCTGGAGCAGGAGGA

AGAGAGAAGGGGGAGGTACTACACACTT

CTAAACAACCAGATCTTGGGAGAACTCA

CTCACTGTCATGAGAACAGCAAGGGGGA

AACCCACCCCCATGATTCATTTATATCCC

ACCAGGCCCCTCCTCCAACATTGGGGAT

TACAATTCAATGTGAGATTTGAGCAGGAA

CACAAATCCAAACCATATCAGTTATTATTT

GAGAGTGAAATGAA rs14951 19 11 44181936 ACATTCCATTAGCTGTGGGAAATGATGTC A/G GGGTGGCTTTCTTCCTGGTTCTGGTATG SEQ 0615

ACTCATGACCTGTAGATTCTGGAGAACTC CC I I I I I IACTTCTTGCTCCAGTAGTGCC TACTGTACATTTGTGAGAGAATAAAAGAA TGGCCAGCAGGCAGGCAGGCAGGCAGG GTGGGAAAGAGAAATAATGACTCAGAGT CAGGGGCACTTGTCTCTAGCAAGTGTAA GATTATGAAAATAATTTCCATGTCCTGGA GTAGCACCTCTTCCCTGGGGCAGCTTCC TCTCCTGAAAGGATCTCAGGGATGCTCA CAGGAGGTTCTAGCACACCCCAACTGGC GGGTACCCAGATTACACTCTGAAATCTG TTCCCAGTGAATTTAACAGCACCCCTCCA CTGAGTTAGACTCTGTTCAGATTTGGGTA GGAAGCTTCCCAGCAAGTTATGTGGATG CCACAACATTAAAAGAAGTACCAACAAGC CCCCACCAGCAACTCAGCCACAATTCTC CCAGAAAATAGTTGAGAAGAAATAACAAG C GACAGTGCAGGCATCTGTATCCAGGCTT TCTACAGAATGCTTAAAGAAACTAAGTGT GCCACTTATCACTTTATTGCCTCTCAGTT TCAACTGTAGTCATCATTGCCCTGTTAGT GATAGCTGAACTGGACCCTGTAAACATC TCTTCTTTGCCAACTGGCATGGCGTCAC ACTGTGTCAGTACAGGGCACTGAAGGGC CAGTGCAGCGCATG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs4755236 11 44205402 GTGGCTTTTCTCCTAGTGCTGGCCCGTG C/G GGTACTTCTATGTGTATGGCATTTTAAAC SEQ_0616

ATTTCATAACTGAACGTCCCAGATGGGC AAAGTTAGATAATGCAGCCCATGCTGTTT

ACCACCTGTTGTTACACCTTCCCCCTTCT AGAAACTTACAACTTGAAACAGATCACAA

CCCCCTAGTCTGTTTCCGGAATCTGACT TTGGTGGGTTAGTTCCCTGGGAACAGGT

GCGGTTAGCACACACCCTGAGTTTAAAA CAGTGAGGAGGAAGATAAAAAATCTCAG

TGCACTCTCTAAGCTGGCTTAGAAGGTA CTGTTAAAGGACATCAGAATTCACTTAAT

GTGCATTAACTTC I I I I IAGGACCATTTAT CCAATCCCTTATTTTATAGATGGCAAAAT

T GGAAGCAAGACACCTTGAATAGGTCAGT

TGCACAATGCACTAGTGGCAGAGCTTCC

TGGACCTACTTTAACCATGTGCCTCTGGT

CCACTTTCTATAGGATGTGAGACTCAATC

TAGGCTGCCC rs869915 11 44205901 CTGTTAAAGGACATCAGAATTCACTTAAT A/G GACCAACAGGTAAGAGGTGTTGAGGATC SEQ_0617

CCAATCCCTTATTTTATAGATGGCAAAAT CTTCACTAGAATGTAAGCTCCTTGGGAG

GGAAGCAAGACACCTTGAATAGGTCAGT AAGTCTCCTTGAATACCTTGTCCATCACT

TGCACAATGCACTAGTGGCAGAGCTTCC TTAACCCCAGTACCTGGAAGAGTGTCCA

TGGACCTACTTTAACCATGTGCCTCTGGT GCATAAAGGTTGGGTTAATAAACATCTCA

CCACTTTCTATAGGATGTGAGACTCAATC AGTCTGATGGAAGCCTATGAATGCTTACT

TAGGCTGCCCCCTGTGGGCTTTTACACA ATGCAACTTCACACAATCCTTACAACAGC £

AAGGTAGAAGATATTTGTTTGATCCTATC CCTATGATGTAAATATAAAAATTAGAATG ∞

TATAGTAATGGGACACGACAAAAGACCT GAAAGAAACAGTTGGAGGATGTTCTTAC

CAGGAGGCTCAAGAAAGAAGAACTTGGA ATTGTTACAATCCCCATTTGACTAGTGGT

AAATGGCCAAGTAAGCATAGCTGAGAAT GTGGGATAGCCACAAATGGAAGGACTAT

CTAGAGAGCAGAACATTTCCATAATCAG CCAAATTATTGCTAAGTCCCTAACTTAGG

GTAAGAGGTGTTGA CATAGAGG I I I I I ATAACAAGAGATAGGC

TTCTGTCCCCAAGGATGCGTGCAATTTAA

ATAGATGGGGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs12790182 1 1 44207953 TCTGGAAAAACAAGTCACAACATGTGCTT G/T GC I I I I I ACTCACTGAGATTCTGCCCATT SEQ_0618

TAGTGGGGAATTAGGACTGTGGTCTTCA CGTGTGTTAGACAACTGTGTGTGGAATG

CACAGAATGGATATCACGTTATTATTCAT TTGTTGCATACCAGGCACTGTTCTTTGTG

GGTAACTGCTGGTCAGTACTGCTGCAGG CGTGGAATACCACAGTGTATAAAACAGT

CTTCCTTCCTGAATTAAGGAATATACTGG CTCTGTCCTCTTTGAGTTTAAATTCTGCA

CTCTGGTAAATATTTTCTCTGAAGAAAAG AGAGGAAAATACATAATAAACAATAAATA

AGAAGGA I I I I I GGTCCCCTTCATTCTT ACCAATATAATGGTGCAAGTGAAAGTTTG

GTAAAGAAAAGGATGAGGTTGGAGGGGT

GTAGCGAGGAGTGGCTGGTTGCGGGTG

CTGTTTGCTTCAGCAAGGAAGGTTCGAG

AAGCCCTCTCAAAGTAGTTGACATTTAAA

CAGGGACCTGACAGATGAGAAGGACCCA

AGCCTTTGGAAGAGCTGGAAGAACACTC

CAGCCAGAAGAAACAGCAAGTGCAGAGG

GCTTGAGGTCTAGTGGTGGCTGAAGAAC

AGAAGGGCCACTGGAGAGTGAGGGGAC

ATGGTGAGAGAAGAGGTGAAGAGTGGAT

GGGCCCTCTGTGACATGTGA rs1845618 11 44209913 AAAGACTGAGTCTTAGCTTTTGGGTTTGA A/G GGACCTTTCCAGATTTGGAAAGCAAGTAT SEQ_0619 ^

GCAACTGGCCGGATGATTTATTGAGATG TTGTTTTCATTGTTTTACAGATTACAGAAT

GAGAAGATTGAGAGAATGACTTGTCTAG CAGACAGCCCTTCTATCCTTTAGGCTTCC

GGATAAGGAATCAAGACTTATGTTTTGGA AGTAGGTCATAAGAATGGTGTATGCTCAA

CGTGTTAGGTTTGTTTATCCAGGTGGAG GAGAAATAGATGC I I I I I I I I AATAAGAA

ATATTAACTAAGTGGTTGGCTATCTTAGG ATGGGACTTTATCATAAGTTTTCATAATC

AACATTCGGGGCTAAACATAAATTTAGAG ACCAATTTAATACAAATCAGGGCAG

GTCACCAGATTATTGATGATATTTAAAGT GATTGAAACTAGATGAGACTACTTAAAGA AAGAGTTTGAAGAAGAGAATAGAGCCTA GGACCGAATTCTCAGAAGTCTGGTGATG GTTGAGGAACTAGCAACAGAGACTGAGA

AGAAGCACCAAGACTAGCCAACAAATTG

TTATACTCATTCATGGTATGGATCTTTTCA

AGGTTAGACTAAATTATACAGAAACACAT

GGGAGAAGGTACTGGAAGTTCCTCATCC

CCAGTATACCCAATTCTGCTTAATCCAAC

AAAGCTCTTATGTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1113132 11 44209979 TATGAAAACTTATGATAAAGTC CCATTTC C/G TGTCTGATTCTGTAATCTGTAAAACAATG SEQ_0620

TTATTAAAAAAAAGCATCTATTTCTCTTGA AAAACAAATACTTGCTTTCCAAATCTGGA

GCATACACCATTCTTATGACCTACTGGAA AAGGTCCTTACATAAGAGCTTTGTTGGAT

GCCTAAAGGATAGAAGGG TAAGCAGAATTGGGTATACTGGGGATGA

GGAACTTCCAGTACCTTCTCCCATGTGTT

TCTGTATAATTTAGTCTAACCTTGAAAAG

ATCCATACCATGAATGAGTATAACAATTT

GTTGGCTAGTCTTGGTGCTTCTTCTCAGT

CTCTGTTGCTAGTTCCTCAACCATCACCA

GACTTCTGAGAATTCGGTCCTAGGCTCT

ATTCTCTTCTTCAAACTCTTTCTTTAAGTA

GTCTCATCTAGTTTCAATCACTTTAAATAT

CATCAATAATCTGGTGACCTCTAAATTTA

TGTTTAGCCCCGAATGTTCCTAAGATAGC

CAACCACTTAGTT

K*

O

Supplementary Table 3

SNP Chr Position 5' Ranking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7945827 11 44211556 TGATACACATTTTATTTGACCCAATTTAAT C/G TTCTGGGAATCATCACTTCGTG I I I I I GA SEQ_0621

TTTTCATACCTGCCAAGAGGGCTTAGAAA CTC I I I I I I IATTAGGGAGAGATTGGGGA AGCCATATTGTGTGACAGTATTTTACAAA ATATGCATTTGATTTTAGAATATTCAGTTC TAAAGCTATCC I I I I I CTAATTATAAAAGT MTAGTAGAATGCTCCCTGGGAGTATAT AATGCACGCTCATAGTAGAAAATATGAAA GGTTTAATTAAACAATCATAACTTGTCTG ATAGAATGAAGAAAAGTTACTTGTAATCC TTGTCAGCAGTAGCATAAAGAACTGATGT TGTCACTTCGAGATAACCATTTTATCATT CGGGAGAAAGGTCTGTTCAGCTCAACAC CAGGTGCTATTTCCAGCTTGCCGTTTATT AGTTAATTTAATTTAGCTGTATTCATATCG TATTTACTTACTTGTATGTATACACAGACA ATTGTTTGTTGTTAG GTTGTAAATATTCTCATTAGCCTGC 1 1 I I I CATGGATTGTATTGTGAGCCTTTTCTCAT GTCATTGACATTTCTTCATAAACAGTTAC TTGTTAGCATAATTAAGATACCATTATCTT AATGTTTTAGAAGTCATGTATAACTATTTT GCTATCGTGGATATTACTTTCTAAATTTTT GCTATTTTAAATAACGCTTAATATCTAATG TTAGTGATAGATGTCCATTTTCATAACTG TTTGTACTCATGACCATTGTGATAGATTC CTAGAAATAGAATTATTATATCAAAGGGC ATGAATATTTTGGG I I I I I IAAGATGTATG TACATACATGTATATATACACATATACATA TATATGTTGTGAATATTCTAAGCATATATA TGTTGTGTATGTATACGTGTGTGTGTGTC TGTTGGTTTCAGGATTGTTTGTGCAAATT TACACTCCCACCAGCAAAATATAAAACTG TTTTACCATGCCTTTTCTTGCATGAAATAT GATTAATAGAAAAGAAATGAGCAATTTTG ATAAGTAAAAGTGAATTTTATTGTTTTAAC TTTGATTTGATTACTAGTAAGACTGAAATT CCTTTTGTGTATTTATTAGC I I I I I GTACT TCCTCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 11037909 11 44212190 TTTTAGAATTGCCTCA I ! I I I CTTCTACTT C/T AAAGGGAACTGCTA I I I I I GAATATTTCT SEQ_0622 TAAAAAGCACACACTTTGGTAGAAAATGA TCTTTCTGTCTCACTTGACAGTATTTTAAT CCATATTGAACATGCTTGGTCACTTGACC TACCTGTATACCTACAAAATGCCTGGGG AAAAGCATTCTAATGCCTCCTTTTACCCT ATATCAAGAACTGGGTAGATGCTCATATG TCCTATTAATACAGCCTTGTGATTAATCTT AACTGTGAAGATATTGCCATGAACTTCCT ATGAGAGAAAGCTTGTCCCCATGCCTTG GGTGGCCAACGTCACGGGAAAAGCAGTT GCTATGCTGCCCCTTATTTATCAGC ATCAAGGTAGGAGGCTCTGCCACTCACT TGCTTTGTGATCTTGGGCAAATATCTATT ATCTGAGCCTAGGAAGTTCTTGTAACTAT AAATTAAATATAGGACTAGATAAACTTTAA GCTCTATTTTAGTTTAAGGTTCTATGATT GATGCGGTCACATT rs3740878 11 44214378 AAAGCCCCATAAACAGGCCTAAGGCAGG A/G AGGACAATAAAATCATGCTTGTGACACCA SEQ_0623 AAATAGAGATCAGAGGCTAAGGCGCACT CACTGCATTCTTTTGTGTTGTAAGCTGAG TTTGGTTGGAGGCTCACTTACCTCTCCAC ATGTTGCATGCGCGTGCACACACACACA CATGTGTGTTTGGTCTAGTGAAAGCCCAT CACACACCTCGCCATTCCTCCATTCAACT CTATGGCTGTGCACTCAGGACACTTGAA CTGTCTGGCTCAGCCAACGGCAGAACTC TTTCTTTCGTGGGGTTACCTGCCAGAGG ACAAGGGCCCAATAAAAAAGGCTTGGAG AGGACAAAAACATACCTGGCTGTCAGTG GGCTTTTGCCTTCTGTAACTGGAAAGAA K* TC G K* rs897007 1 1 44221074 TTCAGCATTAGGCCAGAGGGAAAACGCC C/T CCTCACAACAACCCTATGGGGTAGGACT SEQ_0624 TGGAAAAGCTGCTTTTGAAGTCAAGGGG ATCATTCCCATTTTATAATGGGAAGACTG ACCTCAAGGATGGATTTCAGAAAGGTCA AGATACAGAGAGGATAAATAACATGTTCA ACACTCTTGCCTCAGTCGGGCCCAGGAC AAGGTCAAATAACTAGAAAAAGCTAGAG ATCTGAGAGCACTACAAAAAGAACAAACT CCAAAGCAGGCATTCTGGCTTCTGAGGC TCTCTCTTGGTCATTATGTTTCTAAAAAAA AAAAGTCTTAATTAGATGATACAAATGTA TTTGTTATTATTTCATTTTGAGCTTTTAAC CTTATTAACACAATTCTAGGGTCCAATGA TCATAACATCATCATGTCCACCAACACCA AGGGGACTGGAAATTAACAACTGCTGAG CAAAGCAACAACTACCATTTACTGTATGT CACCTATTATGTGACAGATAATTTACATA TCCAAGCTGTGTTAAAATTGCTTTCTATG CATATCTCATGGATTGCTTAAAGTAATCC CATTAATAATGCATTTAA TCCCCCATACTCATCACCCCCCTTGCCC AACTATTGGGTGTATAGTAGCCTCATGTT ATGGGTTAAGAAATTAAGGTTCAGAGAG GTTAAGTAACTTGCCCAAGGACCCAGGG GTAGAATGTGGTGGAACTGGGTTTTAAA CTCAGGTTTGAGCTGGCAATAGAGCCTG CTCTTTGGATCACACTCTACCATTACATG CCAGTGACTGAGTGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1002106 11 44228649 ATATGTCTTAGACCAAAGCCACCAGTCA C/T GTGTTACCAGAGAGCCTGGGGGTCT SEQ_0625

GGCCTTGCCACCATATAGAACCTTCCCTT

TAGAATATATTTATTTGGAATTTTACTTAT

AGCTGCAAATATATCATTGGCTACTATAC

CCAAGCATCAACTCAAGGAACATTTGGTT

TTCTGGTGAGCACAGCTGAAGACCAACC

AACTAGTTACTGATCCAGATGAGGGAAG

AGAACATTTATTCAGTCATTCTGTTATGC

TAACTATTCATTTTCTCATGAAAATGTAGT

CTTTGGCTGGGCATGGTGGCTCATGCCT

GTAATCCCAGCATTTTGGGAGGCCAAAG

CGGGCAGATCATGAGGTCACGAGATCGA

GACCCTCCTGGCTAACACGGTGAAACCC

CATCTCTACTAAAAATACAAAGAATTAGC

CGGGCATAGTGGCAGGCACCTGTAGCC

CCAGCTACTCGGGAGGCTGAGGCAGGA

GAATGGCGTGAACCTGAGAGGTGGAGCT

TGCAGTGAGCTGAGATTGTGCCACTACA

CTCCAGCCTGGGCGACAGAGCAAGACTC £

CGTCTCAAAAGAGAAAATGTTGTCTTTGC ^W

CAGGCAGTGTGGTAGGCCCAAGAGATAT

AGCAATTAGAGTTGACTAAGACAGTGTC

CCTATCCTGTTCTTGAGCTCCAGTTCTAG

TGGGAGTTCTTGAGCTTGGTAAGATGAT

GTGAGTCCATCAGTGGCCCAGGACTCTA

AGCATGTATGTTTTAGTCCCAGCTGTAAA

TGAGGATTCCATTAACCCCATCTTCTCCA

ATGTATGGAGGATGCAAGAAGCTTTAAAA

TGTCCTTTTCTCACAGTGACTTCCCTTGA

CCATGCCTTAGTTTCCTCAGCCAGAAATT

GGAGACAGCAAGAGCACTTATGCCTGAG

TTGGTGAGATGGAATGATGTATCATATCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs729287 11 44236666 GGGGTGGATGAGGTTCATGGTCAAGCAG C/T GCACATTACCTAACATTCTTATTCTCTCA SEQ_0626

AGGCTCTGACACTCCAGGAAGATCTCTA GGCATTCGGATGTGAACACAGCCTGTCT

GTGGGCTGAGTCAGCTTCCAGCTGTCTG CCTCTTTGGGATGTGAGGAAGTCAGATG

TAAAACGAATCCCTGAGTGTCCTCTGAC GATAAATAGATATACGGTATCATGTGCCA

CTCCCTCCTCCCACCCTTAATCAAMCAG TCATGGTATTATGACACAAACAGTΠTGT

AGCATCTCTTTATTCTCACCTTCCCATTC GGAGGCCAGAGGGGCAGCCTTTGACCT

ATTCACTCATT AGGGGTGGAAGTTGAGGTGAGGGCATG

GGCTTAAGAAAGAGCTTCACAGAGGGTG

CTATCATTTGGAGGATACACTGCAGAGT

GGCTGGGTGCATTGGAGGGGATCTAGG

GAGGAGATAGAGGCATTCTAAGAAGAGA

TAGCAAGTCCAGTGGTGTGGCCAGGTGA

AAAGGCCTAGATGGCTTGGGGAACAACA

AGCTGTGCTGGGTGGTCAGACCCAGTGA

AGGGCTGAGCCGTAGTCCACAGTCAGAG

GAGGCCCTGCTGGCCCTGGCCTTGTCGT

TGTTCTCCCCAGAGACCACTTGGAGGCA

CAGGTCCCAGGGGTGGGCTACCTGCAT

CCCCCGTGATGCCTAAGTCACACATCAG £

GCCAGTCTTCCTCTTCAGCAGTGGTGCT ⁴^

CATCTGGACTCTGAAGGATTTGGGGGGT

GCTCAGCTCCCACAGGAAGAAGCAGGG

GTGTGAGGTAGAGACAACACCCCGTGGT

TTCGCATGTGGTTTGCACATGGCTTTTCT

CCCTCTCTGCTTCAATTCCTGCCCTGTGA

CTTGGCAGTGATTTGGTGTGGAGTGTCC

AAGTGCTACCATGACCCTGAGCCCTAAT

ATAGGACAGGTGTCATTTTTTAAAAAAAC

AAGCTCCCAGCCCAGGTCAACCTAAAAC

CCAGTTGGGTCTATACTGAATGTGAATG

CACTGACACAGGTATCAAATCTGAGATGT

GGTTCCAAGAGAACAATGTCCAAATAGTT rs7116335 11 44239814 GAATCAAGTATAGTTAAAAGAATTCAAGG A/G GACTGGAGGCTGTCAGTGTGGGGAGGC SEQ_0627

AAAGTTCTAAAAGCCCATGTCCTCCAAGT TGCCCATCCATCTGCCGGCTACCCACGA

GCTATTTCAGCCTTGGAGACAAGCCTCT CTTTA I I I I I AAGTTGCCATCTCTGTTGA

CTGTGTGCCCCCCAGAGCCCTCGCTCCC GATCTTAGGCAGGTATCCAAAGGAAATC

ATGCCCCAGGAGTAGTGCTGGCATCTGG CTCACCTCTCTTAGCTTATTCGCATAGCA

AGGGCAGTAGCAGCACCTTAGTGTCAAG ATGAACCACGTGGCAGGTAGATGCTTCT

CCTTGCCATGCTGAGACCTGTGCCCAGC CTCCACCTGCCTTCATGAGCTTTAGCTCC

AG AG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs897004 11 44240501 AAAGAGGAGGAGAGCCAGGTAGCTCCA C/T CCTGTTCATCTCGTCAAAGGCAGCCACG SEQ 0628

GAGTGGGCCAGGAGGGAGAGCAAGGGA TACCCCAGGCCTGTCCTCTGTGGCTTGC ~

ATCAGGACAAAGAGGAGGACAGACAGGT CCNGAGCCCTTGGGGGCCACCTAACCA

AGCTCCAGAGCAGGCAGGGAGGGAGAG CACTAAGTATGATAGGACCACCGAGTTG

TGAGAGCTTTAAGGGGGCTCTTCCGCAG GGAGGAAGCTTAGAAACCCTCTAGTTAG

TGGCCCCGGCACTCAGTTCCTCCATGCG TCCAGTCCCTTCACAACAGAGAAGACCC

TCTGCTCTCTGGCTGGGCTAGACCCAAG TGGCCCAGAGTGGAGACATGACTGCCCT

TCAGGCAAATTTCAACCCAAAAGCTTGAG GACCTGTACTTGCCCTGAGACTAGGCTG

AAGAAAAGGCGTCTATTAGAAGACTCTGT AGAGAGGAGCCTGGGACGTGCCACCCA

GGCTATGGCTGCCTGTCCCAACACACCC GGGTGTGAGGGCCTGGGCTTCGTTGGC

AGGAAGTGTCTAGGATTAAACATGCCAAT ACCAGGGGCGGCCGGTGCTGCATGGAG

GTGAAACAT CTCCCCTCTCCAATGCCTCATGGGCATT

CACTCA rs3802805 1 1 44243142 TCCCCTGCGACCCGGTGCCTGCCTGCAT C/T GTGGGCCAGACGCACATGGGCAGCCTG SEQ_0629

GTCCCCTCATGCCCACCCCCCTGCTCTG TTTGGAGCAGCCAGCCTCAGCCCAGGCC

GGGCCAGCAGCGTCACCGACTTCCTGA TCAATGGCTACGAGCTTAACGGCGAGCC

GTGTGTCTGGGGCTGGCAGTCA GGACCGCAAGACCTCGAGCATCGCGGC

CCTCCGCATGAAGGCCAAGGAGCACAGT

GCGGCCATTTCCTGGGCCACATGACAGG 6

GCACCCCTGCCCCGTCCCCACCTCGGG ^

ACACCATGGGCCACGCCCATGTTTTCCA

GGCCCCCAGCCTCCCACTCGACTTTCCT

CTTAGGAACCTGGCCTGGGCCAGGGGC

CTGACCCTCAGCACTTTCAGCCGCCCCA

AGTCTGAGGCCCCGTGGACTGCTGGGA

GGGAGGGGGCAGCAGGCCCCTGGCCCC

TCCCTGGCACTGAGGCCCTGACCCCTGC

TCCCGGCCACAGGCAGTGGAGAAAGCC

AGGTGGCCACG I I I I I CAGCTTCGCATC

CATGATAAGCTGAAA rs4755800 1 1 44244257 CTCTACCTTCTAGGCACGTATAAGGAGG A/G CATTTCTCTCTGCGGTGCAGGGGAAGGG SEQ_0630 ^'

TAGAATTAGGGTGTGGGGGAGACCCGG GGACCGGTTGGCCTCCATCACCCCCTCT

GAACCTCTCAGCTTATGCACACGGGATT CAGAAGAGGTCTGAGCACACACTATGTG

CCTGGTAACCTCATGTGGGCTTCTGCTG GTGCTGTAGGTGAGGTGGGGGTAGGAG

GCCTGCCCTCCTGCATGTGTCTGGAGCA GGGTGAACAGGGCCCTGTGTTGGGTTCT

CACTCGAGGGAGGCATTTTAAAGCAGGG CCCTCCAGCTGTGCGCTCAGGCAGCAGA

AGAAAGAGCTCAGCCCCCATCCTGGAGG GCTCAAAGCCAAGGAGGGAGCTAGAGTT

GAACC CCATC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10769024 11 44245888 GCTGCATCTGCCCAAAACGCTCCCGCTT C/G AACCTTGGTCTTTGTCCTCAAGAGCTGAC SEQ_0631

CCTCCACTTGGCCCTTCGGTTCTGGAAC AATCTAGAATCATCCACTCTGAGCTGGG CAGACCTACAAGACGCGAAAAAGCCATT AAGGTATCTTACCCCCACTAGCCATGGG GTCACCAGGGTGAGATGCCCGCCTGGA CGTGATCCTGAGCCAGAACTTTTA M i l l GGCCTCACTTTCAGGCAGTGCAAACTGT CTAAGCTTGAGAATCTAGAGCAGCCAAG TCCCTTGAGCCCCCCATCAGTTGCAGTG TGTCACCACCTATAAAACAAGTCACTGGT CGTTTGGGAAACGGTGCGGCCACACATA CATCTTAGCAGTCATCTAAGCAGACTCCT AATAT rs10769025 11 44246011 AGGCAGTGCAAACTGTTCCCTTGAGCCC C/G AGAATCTAGAGCAGCCAAGTGTCACCAC SEQ_0632

CCCATCAGTTGCAGTGCGTTTGGGAAAC CTATAAAACAAGTCACTGGTCATCTTAGC GGTGCGGCCACACATAAATATCAACCTT AGTCATCTAAGCAGACTCCTGTGGAGAA GGTCTTTGTCCTCAAGAGCTGACAATCTA GCTGATAAAAGCTACAAATGCTCCTCCA GAATCATCCACTCTGAGCTGGGAAGGTA GATGTGTTCTCCTAGACAATCACACACAG TCTTACCCCCACTAGCCATGGGCGTGAT TTTTGCCACAGTTTTCCAAAAGGTTCATG CCTGAGCCAGAACTTTTA I I I I I CTAAGC GCTCTCTAAGGCTTATTGGTCCAGATTCA TT rs 11037922 11 44246212 AGAATCTAGAGCAGCCAAGTGTCACCAC C/G AATGCCTTCCTCCCTGCATCCTGTCTGCA SEQ_0633

CTATAAAACAAGTCACTGGTCATCTTAGC GCCTTCTTGTTGGAGACAGTCTCCCAGC AGTCATCTAAGCAGACTCCTGTGGAGAA TCAGAACTCCCCTGTGTTAAAGGGAGAA 4- K*

GCTGATAAAAGCTACAAATGCTCCTCCA CAGGGGCTCTGCTGGGCAACAGAGGCA GATGTGTTCTCCTAGACAATCACACACAG GTCAGGGAAGACTTCCTGGAGGAGGGA TΠTGCCACAGTΠTCCAAAAGGTTCATG CAGGAGCTGGGCCTTGAATGGTTGGCTG GCTCTCTAAGGCTTATTGGTCCAGATTCA AAAGGAGGAAAGCCAAGGCCTAGGTTTA GAAACAGCAAGGCATACTCCAAAAACCT AAAGAGGTCAATTTGAAGGAAGCGGT rs4755802 1 1 44246879 GCTGTGAGCACTGGGG I I I I I GGTGACG C/T CAGGAATGGCTTTAGGCTGATTCAGAGA SEQ_0634

GGGAGTATTGGGTCCTTTTCCTTTGCAC TGGACCGTGGTGCTCCTCAGAGGGAGG GAGCATTTCTGGAAGGCTGAGAACTTTC CCTCTGCCAGCTTGATGTGCACTTGTCT CCAAGGCTCAAGAGCAAGAGCTGCCCTA GCTGGCTTTGCAGACTCAGATGCAAGTG CCCCTGGCCCATGACTTAGGATCTGGAG GGCACACCTCAGACAGCACGCTGCAGAC AAGGGGTGATGGGGACGGGGTGGGTGA CGGGAGAACAGAGCCATGACAATAGCCT GAGAGGGAGAGTGAGGAGGGATCAGCT CAGCTGCAGAGCCATAAGGAGCCTTGCC TCCAGG AGGCC rs7949067 1 1 44248060 TGTGCTGCTGAAATGGGATCCCTCTTTAT A/G CGGAGAGAGATGGCTTCTC I I I I I CTTTT SEQ_0635

CAGTGGCCTGGGATGGGAGACTGGGGC TGTCACTGTGACTGTTGGGGTTCTCCTT CAGGATGAGAGAATGAATCAGAGGAGCT GTGTCTCTGTGGGTTCCAGGTCCCCATG TGTTTTCATTTCATGTTTAATTTCCTGCAG GTGGGACTGTGGAAGTGGAAGATGTCCC GCTTAGCTCCGTCTTTCCGCTCCTTCCTC TACAGGCTCTGGAACAGAGGATCCAGGG AGCCTCCCAGGGTTTTCTGTGGGGGAAG ATGGGCGGGGAGGGACCCCGAAGAGGG CTGGGGGGAGGGGAGAAGCCACTGGAG AAGGAGGTGGCCAGCGCCTGGCAAAGG GC GGTCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1318969 1 1 126027239 CTTGTAC AAGTCTTG AAACACATATTAG G A/G AAAACCCAAGGTTCTGGAGGTCACTGGC SEQ_0636

AATGATTATACCAGAGAACCCAATAAATG AGGCTGGAATTTCAGCCCCTCAGAGTGA

AGAAGTTTTGGAGACAGCATTAATTGTGA AGGGATGGGCTTCTTTGGTTGAGTTCCG

TGAAGGGTTCATAAAGCAGTGGATGTTC GTGTCTGTTAACCCCCCACCCCTTGTTCT

AATTTTCCCATTTGGGGTGGTAATAACAG TTGTGTGAAACCAGCACCCACTGGCCAA

GTCTAATCATGACACCTCCATAAAGTCAT AAAGCCCGGGTTGGGGTCTCTGTGGGTT

GGGAAGTCCCTAATGAAAGTTTCTGAATT GATGGATATAAACCATCTTCTTTACTTAG

CAGATATTTAAATGATGGTAGGGTAAGTC GGCACAAAGAAGAACCAAGACAGGAGAG

ATTATGCCAATGGGAGAATGAGGCAAAA GAAGCCTGGGCCAAGCCTGCCTAGGGA

AGCGGAGTTCATCCTTGTGCTAACCAAA GTCTATCGTGGTAGGAACAAGAGCTACC

GAAAAGATGAAATGGTGAGGGCTCATCA ATGCCTTGAGCCCATTCTAAATGGTAGG

ATTCTGGGCCAGGAGGAAGATAGGCACT CAAGTGCTAGATATTTGGCTCACACATTT

AGTAGGTCTGATCTGTCTGGAGGATTCC CATCCTCATAACAGCCCTATGGTGTAGA

TTTAA GAATATCATTATCTCCACTTCACAGGTCA

GGGGGCTGTGGACAAGAGGTCAGGCCA

TTTGCCAAAGTCCTCCACTCAATCTATAG

GTAGCGGGGCTGGGTTCCTAAGGATGTC

TGATTCTGAAGCCTGGTCCTTGATCTCTG

TGCTCCATGACCTTCTGTAATCCCCACAG 6

TCTCCCAAACATCAATGCTGTCATTACAA ^

CCCCATCACCTACCCTTACCCTTACCACA

CCAAAGAGTTACTC I I I I I I GAAATCTGA

ATCTCAGATTTTCACTTTCCAGGCAATTC

ACCAGGACAGAGGCCTTTCAACTTTCCT

CCCTGAGATCTTCCTCCGTGAACCAACA

ACAAAAGGACCAGCCACCTCACTGGTCC

TCTGTTGCCAGTAGAAAAAGCCCTACAA

GGATTAATGCAAGAAGAAGTTCTGCTTTG

GGTGAGACATCAGTTTAATTTATATTTGA

TTAAAAAAGTCATTCAT rs544503 11 126028522 GAGAGGCAGACAGTGCACTATCTACAGA A/C GCCTCACCGTCTTTGCTGTAAGATGGAG SEQ_0637

ATCCAACGGAGGAGGCGGTACTGGGGC ATAATGATACCTCATGGGGTTGTCATGAA

CCGTGGTGGCAGAGGATGACGGCTTTG ATTCAAATCAGGAAATGGATATGAAATGG

CAGAGGCAGAGGAACGACTGACTTGCTC TTCTGAAAGATGTAAAGAGCAATATAAAC

AGTGAAGGATGGGCAGACTTGGGGTGG ACCAGATACGGAATGAGAAAAAAGCGGC

CAGAAGAGGCACCAGCTGGACCCGCCC ACCGGAAGTGGCATTTTGCAAACTCCAA

AGGAAGCCAAGCCCCTGTGCTGCCTCAG TCCCCCAGGACCACATGTGAAGGAGCTC

TTTGTAAGTAGGCATTTGACCTTGTGGG TTTTCAAGGTCACACGGACACTCTGACC

GAATCACTCTCTAG CGACTCTCTCCTGGCAGCATTCAATGTG

ACACGCCAGGGCAATGAGAAACGGGAG

GGGCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1783988 1 1 126028590 GAGAGGCAGACAGTGCACTATCTACAGA A/G GAAATGGATATGAAATGGTTCTGAAAGAT SEQ_0638

ATCCAACGGAGGAGGCGGTACTGGGGC GTAAAGAGCAATATAAACACCAGATACG CCGTGGTGGCAGAGGATGACGGCTTTG GAATGAGAAAAAAGCGGCACCGGAAGTG CAGAGGCAGAGGAACGACTGACTTGCTC GCATTTTGCAAACTCCAATCCCCCAGGA AGTGAAGGATGGGCAGACTTGGGGTGG CCACATGTGAAGGAGCTCTTTTCAAGGT CAGAAGAGGCACCAGCTGGACCCGCCC CACACGGACACTCTGACCCGACTCTCTC AGGAAGCCAAGCCCCTGTGCTGCCTCAG CTGGCAGCATTCAATGTGACACGCCAGG TTTGTAAGTAGGCATTTGACCTTGTGGG GCAATGAGAAACGGGAGGGGCTG GAATCACTCTCTAGCGCCTCACCGTCTTT GCTGTAAGATGGAGATAATGATACCTCAT GGGGTTGTCATGAAATTCAAATCA rs523249 11 126031391 TAGATTCTGGGACTATACCTTATCTATGC A/G TGATTCAGTTTCTTCATTTGCAAAATAATT SEQ_0639

TGTGCAAAGGAATAAGAAACTAGTGCTG TAAAATAAGATAATATGTTGAAAACTCTTA TCTCGGGAACCAGCAACACAGATGTTCC GCACCCAATAAGCCTTCAAAATTATAATT CAGGAGCAATGTTTGCAGGTGAGTGAGG GTTTTGTATGTTTTGGCAAGAAAATAGAA TCAGGGAGGGCTACAGAGTTAGGACTCC TAATATTATTATTGGAGTCTCTGGAAAAC GAAGTCAGAAAAAAAGCCTGTTGGTTCT CTAGGTTTCCAAACCTTTCACCTTAAGTA

4- GCCGTTCATATCTGTGAGATATCAGGCT GAl I I I IATAAAATGAGACTTCACGTGGA K* GGTTTCTTAACCATAACCTCC ATCTCAACATACAAAATTGGCATAAGTGG GGGATAAGGCAGCAGGTGACAGTGGTT GCGTGCTCCTGGGCACCGCCTGCCCAG CCCCTGCACTGATTGTCTTACCCACAGG GGCAGTTTAAATCTTCATGCTTTTACCAC CTTATACTGAGTAAGAAG rs546252 11 126032473 CCCACACTGGGTGAGAAGAGGAATGACA C/T I I I I I GGAACTGGCCCACTATTTCTCTAA SEQ_0640

CTGCCCTTCTTTGCTAAACAGCTTGTCCC TATTTTAAACCAGCAGTTGTCTAACTAGG ACTCTGGCCTTGGTTCCTCCAGCACTCA CCCCTCAGAGCCTTGAGATTCCATGAAG CCTCTCAGACCTGTGCCCTGCCACATAT ATTTATTTATTTATTTATTTATTTATTTATTT GGAGGTTTCTCCTGATCCATGTCTTTCTG AATTATTTATTTGGAATTCTCATTTTATTC GGTTGGTTTGCTTGGTTACTAAAACATGT TCCTGAGAGATTATGCATGATCTATTATA TAACTGGCTGGATGTCATCAGGGCTCTA AAATATATAGGTAATACAAAGTTCAAAAG C CCTGTCATGTTTATAGAATAAACAAATGA AAATTAAAC rs7950175 11 126033245 GACCAGTCCACAGAGCTCTCCTCCCGGA C/T TGTAGTGGTAATGCTTGGAATAACAAGTA SEQ_0641

TCCCATCAGTTTCACAGAGAAGATGGCA GTTATTGTCATACAAGAAGAATAAGGAAG TTGCCAAAGCCTGGGGCTGCTCACCCAA CTTTTGATGATCTCGAATAATGTGGATAT TCCCTTTGTGTCTGTCACAGCTCTCCCAT CTACATCATTTTTGCATGTCAGTGGGTAT TTCTGGAGGAGTCGAGTTAGCCCCTCCT ACCCAGCTTTGAGGGAATGGTTA I I I I I A TCTCCTTTGAATCTCTTCTCTTTAAGACTC TACCTTTCAAGACTTGGTATGCTTAATTA GCAGCTTCAATACCCAAATGCTGCCATG TCTAGGGAAACTCATAACCCCAACTT T

Supplementary Table 3

SNP Crtr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1346306 11 126035147 GGATGCCTTCCACGGGCTGATGTGCTTG CfT TGCGCAGCTTGTGGAGTGGCTTGGAGAC SEQ_0642

ATAACAATGCAAATGCAAGGAACATGCC CTCCAATAGCCCTGCTAGGATCTGGGGC CCAGACAACTGAACTGGAATTTCTATGAG AGACAGTGGGCACCAGCCGATGCCAGG CACAGCCCAGGAATTTGCAATTAAATCAA GTATGTGAAGGGCAAAGGAGGCCCTTTG GCTCGTGGGTGATTCTTATGTTCAATAAA GGGGAAGAGAACTGTGAGGCCACAGGA GTTTGAGAAGCATACTACTAAGTGTTGCC CTACTGAAATAGAGCTCCATGCCCTTCTC TTTAAAGGCAACTCGAAAACTTGCAGAAA CATTGCCTCTGTAAATACCCTGGGGATC ACATCTAAAGAAGGCTGGAGGTGGCCTG ACTTT GTGCTTATTGTATAAGAGCATCTGGCAAG CTCCACCCTCTAGGTGGCATTCTGGTCT TGAAAAGCATGATAAAAATTTGGGGTTGC TACTAAGCAGGGACAA rs7113610 11 126054506 ATTCGATTACAATGATGTAGCTACTCAAA AJG TGTCCTTTGCTAAGTGCTTTGTGTTCATT SEQ_0643

AGCCGCTCCCAACTTCCTGCTCCCCTGC TTGAAGCTTCAAAACATGTTCCCTTTAAG CCACCTGCTCCTGAAGAGCTGAGCATTT GGAGCTACTATGACCTCTGTTTTATAAAG GGCCAAGTTCTGACCAATGAGATGTAAG GAGGACACGAGTTTTAAGTGTATAAGGT GAGAACTCTGCTGAGGGGTTTCTGGGAG CACACACCTATTCCAGGAAAGAGCAGAG AGATGCTTTGC I I I I I GACAAAATGGCAA CTAAGATTTGAATCCAAGTCTTTCTGACT K*

GTCACATTATGAGAACTTGCTGGTGCTG AGAGAGTTATTACTATTAATCATAATATTG

CCCTCTGCCCCTTCTTCCTGAATGTGGAT TGACTTTGTAGACAGTTCATCTCAACACT

GTGATGACTGAGTTTGGGCTGCCATCTT GAACTCTGGGAATGAGTGTTACTTAAAGT

GTGAGCATGAGGATGAAAACGTAACATG CTGGTTGGCATAATAGTACTCAGTATAAA

CCATGGATGGTGGAGAATCACCAGGGAG τCACGAAGTTTTTCCACATGACCCACTAA

AGCCTAGGTTCATGATTACATCACCCAG AATAAGGTGAAATTCAGTCTTATTGGTGA

CTGACAGCCCAACCCTGGGGTCATCTAC TTGAAAATTGCATA I I I I I I ACCTGCCTCA

TTCTGGACCTΠTGTTAAGCAAACAATAT ACCCACTCCAAATAGCCGGGGTTGAA

ATAGCCTTGTGGTTGAAGCCACAGTTAG

AAGGGCATTATGTTCCTTGCAGCTGAGA

AACATACCTACATAATCTAAATGGCTCCA

TTTATTGAGCAGCATATGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4937178 1 1 126058195 GGTTAGAGTGGGTGACACTGAGCATGTA A/C AGTGATCTTACCGCCTCAGCCTTCCAAA SEQ_0644

ACTTAACCTCTCTGAAGCACAGTTTCCTC GTGTTGCAATTACAAGCGTGAGCCACAG

ATCTGCAAAATGAGGATGATAATATCCTC CACCGGGTTACTTTGTTACTCTTTAGGGG

CTCCCAGTGTTGCTGGGAGGATGAAGTG TATTGGAAATATTAAGAAAATACAGCAGG

AGATGAATCTGGTGATACTGAGTAGGTG GAGAGATTGA I I I I I AGGATTTAAGAAGA

TGCAATCAATATTTG ! M I I I CCTGCCACT ACAAGAATAGTTTTGGGAGTTCTGGGAG

CCTTTACCAGGC I I I I I I I CACCTCAAAT CTACTTCCAAGGGCATGAACCAAATCTG

GAGTGATGACCTCTGAGTGCGGAGCTTT GAAAGTAGAGTTGGGGTTGTGAAATATTA

TTTGTCAA I I I I I I AAAGACAGTGGTCCC GAACGTGTGGATAGTCTGATGGTTTGCA

CAGCA I I I I I GGCACCAGGGACAGGTTT AGTAAGT

CATGGATGGCAA I I I I I CCATGGACCTG

GGTAGGGGGTGGTTTCTGGATGAAACfG

TTCCATCATAGATCTTCAGGCACTAGTTA

GATTCTCATAAGAGACACAGCACACAGC

CTAGATCCATCACATGCGCAGTTCACAA

CAGGGCTGGTGCTCCTAGGAGAATCTAA

CGCCTCTGCTGATCTGACAGGAGGCAGA

GTTCGGGCGGCAATGTTCACTCACCTGC

CGCTCACCTCCTGCTGTGTAGTCTGGTT W

CCTAACAGGCTGAGGACCGGTACCCCG

GGGCTGGGGATCCCTGTTCTATGAGGAT

AGAAAATCTGGTAAAGTAATTCACCCTAA

GATGCCATTAAATTACTATGACCTCCTGG

GCTCAAGCAATCCTCGCACCTCAGCCTC

CCAAGTAGCTAGGACTTCAGGCATGCAC

TACTATGCCTGGGTAAC I I I I I I GA I I I I I

ATTAGAGATGAGGTCTCACCATGTTGCCT

AGGCTGGTTTTGACCCCCTGAACTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs709239 12 91008608 TAAACCCTAAATTACTATCAATACTTATTT C/T GAAGAATATTCCCAGTGCCAACTATAGTG SEQ_0645

CACTAGTGTGGGAACATTCATACTGAATT CCTTAAAGAGGCCTTTATTGTTTGCCAGA

TCTTCCACAAACTAAAAAGTACAATCATA TTTTAGCAAATATATTTCAAGCAGGAAAG

CCTTAAGTATAACTTTATTTGAAGGTTTAC ACCAGACCCATGACAAATTACTAAGCTCC

TATAATAGATTTGCCGTTAGTTAGGAGTG TGGTTCATAATCAAGAGTTGAGAACACAG

GTGGTGCATGCCTGTAGTCCCAGCTACT CAAGAAAAAAAAAAAAGACTGTTTTATAT

GAAGAGGCTGAGGTGGGAGGATGGCTT TGTTCATTTGGTGACCTTAGGCTTACTGA

GAACCTAGGAAGTAGAGGCTGCAGTGAG ATCAGCATTTAACATAAATAACAAMCAG

CCATGAACATGCCACTGCACTGTAGCCT

GGGTGACAGAGTGAGGCCCTGTCTCAAA

AAAAAAAAAAAAAAGAAAAGAAAAAAAAA

AGATTGGCCGTTAAAATTATTCTGAATGA

TTCTAAATTCCCCAGAAAAATAGTCACAA

CTTAATTCTGGTCTACTTCCCCAGCCTTC

CTAAATGCTGCTTCCTATTTTGTACATCT

GATGAACTGGACACAATGGACAATTTGT

CAGTCCCCAAGCATGCCTGTACTTTCAC

ATCATTCTACCTCTGCACTCGTGGTGTTC ^

TTTAGCTCGACAATATCCTCTCTTGCTTC £

TCCTTCTAAGGTTCAGCTCCTCTCCTATC

CATTGTAAAGCCTTCTTAGCCAGAAAATA

TCCTTCTCCCTCTTCTCTGCTTTCAAAGT

TCATTCTTCATGCTATGTGCTGAGATATG

TCCTTCCTCCATTTTGTTCTATCCCACTG

CATGGGAATCCTTTATTCATAGGTTTGTG

AGCTCCTTCGAGTGTACAACCTATGTCTT

CC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs1798046 12 91013779 AGAATATATTCAGCTCTTAAGTTGTATGG G/T TAATTTCAGCCTTTATTAATTTTCTTCTAA SEQ_0646

TGAGAGCTGAGATAGAGGGAAATACTCC TAACTTAAC I I I I I I CAGTTATTATGGTTA CTGAACTTTTATTTGCTATTTTGAAGGTTA I I I I IAAGTATCCTAAGTTATATACTTCAT AATTGAATTCTGCAATGAAACTTTCTGGG AMTTAMCATTTTTAATAACATTTAAATC TCTAGATCCTTTCTTGGTCTATGGCTTTC TATC I I I l I I CTTATACMCTTAAAAATTC ATGATGCTCCAACTTCTTCTTTGGTTTCT TATTTTATTAGTCTTTATATGAAGATTTTC TCATGTTTTCTTTGTATTCTAAGGTCAACT TAGATAATTTGTAATCTCAGTTTTGATTTT TTGATTATTAATACTTTCTAAAAAATAATC ATCTTMGATAMCTAGG i I I I I AGAAGA CAATTCCTTTAGACTTACAAATGTATTGAT CTAGTTCTCMTATTCMGTATTTAACTTT ATTAATTTGCACTTAATTTTCCTCAGAAAT TTTGGTCATTTTCTTACCTCGTTTTACTAG TATTTTATAATTATTTTAATATATTCTGTAT ATAAAGGCTAATTAATATCTCTACTTTTAA CTGTAGTTATATTTC I I I I I CCAATTTCAA AAATTTATTAAGGTGGGCATAAAACAAAA CGTTGTAATTA I I I I I I CTTTCTCTCCATC ATTTATTAATTCAATACAAGTTGTTGAGG TCTA I I I I I I CATATTCTAAAAATCAATAT GCCTACAATGTTCAAAGCACTGTTCTCAG GTCTAGAGTTTTATTTCATTG I I I I IAGTT TGCAGAGGATACAGMGTAMCAAAACA CAGGGATCTAAGCTTTACTTATTTAACAT GGCMCTMGTTTGCCTTATTCTTTTATG TGCTATTA I I I I I GTTTGCTGCTTCA GAGCTTACATTTTCATGGAAGTGTATA rs35666 12 91036838 GATTTCTTATTTATCTGAAGGTATACAGA A/C CTTAAATCATTTAATATATGGGACTGTAA SEQ_0647 4-

W CTGCCAACATTTTAGACTTATCTCTCAGT ATAGAGAMTCTGTACATTATGAGATCTG K* CTCTGCCACTGAACTΠTATATATGGCTG ATTTCTGGTTATGCCTATAGATCTTTATTT CTATCAAAATATAACCGGTTTATTTTCATA TCTTTATCCCTATAGATCATTTTCTTCTGA TTTGGAACTAATATAACAGTATCACAAAA TGTTMGTGTTATATΓTTTGAMTGCTCCT

TCTTTTACAGTAAGATAGTTTGTAATACC AAACAAGTAAGCCTTAGATTGTATTAATC AGCCGACCCAGCTGCTTAACTGAGT CTGAGGATTGATACCATTTCCTC rs17251474 12 91067786 TGTMGTTTGCGCTATTATAGTTATrTTM C/G MGAAACTGATGTGGAMTACACATTATT SEQ_0648

ACTGTTTTTATATTTAGTTGCTTACTTTTA MTAAGGAGCACGGATTTGACTTCATTAA AATTTATATTTACACAGAATTG I I I I IAM ATTTGTAAACTTCTGAACACTAAAAAATC GCAGGAAGTA AGAATAACAAGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7294785 12 91083266 TATATCACTTTTCGCAGGCGCCTCTTCTG A/G CTGCCAGTTTCACCAGCCTTTTAGGTGTT SEQ_0649 GATTTTGACCGTTATAAAGCAGAACAAAT GGTTGGGACCCTACTGGCCTCTAACGCT AGATAAAGAAAGAAGACTCACAAATGGC GG I I I I I I CAGTAGTGTATCCACCAACTG I I I I I I CATTAAGATGATATACCTTTCATT GTTCTGATTGGCACTTTTCATCTTCAAAT TCTACTTTTTCTCAGTTGATAAGCCCCAA ATGCGATGTTCTGCCTCACTGACAATGG AATAACACAGAGACACTGAAAAAAGCCTT CAGATGGGCCAGTAAATCTCAATCTTGA CTTACAACCTTCTTACAATTTTCTAT CCTCACATTAGGATCACCTGGGAAAGTG TTAGAAAAACAAAATCCCAGTGTCCAGG CTTCTCCCTGGACCAATCAAATCTGMTC TCTAATGGTAGGATTCATGCACTGATATT TTTTGAAGCTTCCCAATGACTGCCATGTG TGGCCAAAGCTGAAAACCCCTGTTAGAT TCTATTTTGGTATATTAACTATGATCTTAA CTAATGAAAGTT rs12582672 12 91104286 TGTATAATAAGCACTATCAATTTAATAAGT A/C AAATTACATTGAGACCTTGTTAAATGCAG SEQ_0650 TA I I I I IATATTTATTTGTTTGTTTGTTTAT ATTCTGATTCAGCAAGTCTGGAATGAGTA TTATTTATTTTGAGACATTGTCCCACTTTT AGAGTCTGCATTTCTAACAAGTTCCTAGG TCACCCAGGCTAGAATGCAGTGGCACAA ATCCTACTGTTCTGAGCATGACACTTTGA TCATGGCTCACTGTAGCCTCAACCTCCA AAAGCAATGCTTAGGCGGGGCGTGGTG GGCTCAAGCAATCCTCCTGCCTCAGCCT GCTCACGCCTGTAATCCTAGCACTCTGG CCAGAGTAGCTGCAACTACAGGCACCCT GAGACAGAGGCAGGCAGATCACGAGGT CCACCACACCTGGCTAATTTCTGTATTTT CAGGAGATGGAGACCATCCTGGCTAACA TTGTAGAGATGGGGTTTTGCCATGTTTTC TGGCGAAACCCCGTCTCTACTAAAAATAC CAGGCAGGTCTTCAACCCTGAGATCAAG AAAAAAATAGCCGGGCGTGGTGGCGGG CACTCCCAAAATGCTGGGATTTTTATAGG CGCCTGTAGTCCCAGCTACTCGGAAGGC CATGAGCCACCACACCCAGCTTTATTTAC TGAGACAGGAGAATGGGGTGAACCCGG I I I I IAACTTTTGTGGAAGGCAATCAACA GAGGCGGAGCTTGCAGTGAGCCGAGAC CAGTTACTATCAGAAGATGAGTTCATGCA CGTGCCACTGCACTCCAGCCTGGGCGA CCTAAAAGGAGGGACAGCAAAGGCATTA CAGAGCAAGACTCCGTCTCAAAAAAAAA AATGCAGCTTTCAGGGAAGTCCTTTGTAA AAAAAAAAAAAAAAAGAAAAGAAAAGAAA ATGCCCTGGAGTAGAAGTCGCGTACTTT AGCAATGCTTAGTCAACAGCAGGCATCT AATGTGCATA TCAGACCTGCTGCCCA I I I I I GTA rs 12824340 12 91116967 GTGGGAGGGATGGTCCAGGACCATCAT C/T GCTGCTGATCCTAATAAAGGATTTTAATG SEQ_0651 GAGAAGACGTGGAAACCAAAGGACCGTG GAGTCAGTGCCATGATCTTTGATTTTAAT TGCTCAGGGAATCAAAATTGTTTGTTTGG AGCCCTAGGAGCAGTATCAACAGGGATT GCTGGGACATTGTATTCAAAGTGAGGGG GTTGAGTTGAGAGAGACCAGTTATGCCA TGGTAGAAAAGGAAACTGGGAAGGTAAA GATGCTAAGTCTAGGCTTGACATAATTTT GAGAGGTCAGCATGTTCTTAGGAAGGGT CAGCATTTTCAGTGCTAAAGATCACCTTT GGTGAGTAGCATTCTGATGGGTATGTGC CATTTCAGTCCTGACAGCCTGGGGAATG TCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs17020113 12 91118086 G I I I I I CTATTTTGAAATAGCTAAAATGTC C/T GTGGAATTATGAAATCAGAGCTTGAAGA SEQ_0652

TTTGTAGAAAATTACACAGAAATAATCAT GAATAAAAACGGCCAAGACAACTGCGGT

ATATCATACAGCACACTAAGAGATGTAGT AAACAGCAACAGTGCATTTTACTTTTATA

TATGTGCCAAGA TTTCCCACAATGCCT rs 12821466 12 91119661 CATACCTGTAGTCATGATGCCTAAAAAAA CfT GTCAGGTGAAATATTTTGATTATACATTTT SEQ_0653

ACCCCAACCTGCATTTTATAAGCTTCAGT GAATCCATGATTTAAGTATGTCTGACAGT

ATTTTCATATCATCTCACTATATTTCATGT CATAAATGTCCCAGAAGGCAATGAGATT

CATCCAATAGCATGCTTATATCATCCAAC CATGTCCCAMTTTTATAGCTTTATGTTTA

AATA I I I I I AGC I I I I I AACAAGATAGTTT AATTCTGCAGCCAAACTAAGTATTTCTTT

TGCTATCTGATTTGACC I I I I I ATTTGAC TTTTCCTGAAGATAATTAAATATTATTATA

GTATATATA I I I I L AAGAAACAAC GTGGCTGTTTCTGCCTGAAACAAT rs 17790100 12 91129962 AATCCTTCAGATGCTTTCTTCCACAAGCA CfT GGAAAAAACTGTGTTACTGC I I I I I TAAA SEQ_0654

AATTTCAGGTCCCTTTCAAAGTAAAATCA TTGGTTTCTATC I I I I I I IATGTGTCAGTG

CATATTTATTATAGTATTTGTGCA I I I I I I ACAATGGTACGCCCTAACCCCATAAGGC

AACCATTTAAGA CTGTGGTTΠTAT rs12813308 12 91130335 TATAAAAAGAATGTATATGAC I I I I I CTCT A/G TGAAGGCTGTTTGCCTATTCTATCAGTAA SEQ_0655

CCAAAGATTAAAATTTACTAGTATAAAATT ATTCATAGTTGATGAGGAGAATTTTCAGC

ATTTAAAGTCTGAGTGGTGGAGCCCATG TTCTGCAGAGAGGCTCTATCTGTCTAGCT

GTGTGACATTGCTΠTCAGGGCTTTAAAC TTGAATTGTCTAAACTAGTTGTTCTCAAA W

ATCTTCTATGTGAGAAAGCCAAGTTTAAA CTTGAGTGTGCCTTGGGATCACCTGAAG

AAATAGTCAAAAGGATGATTACCCAATCG GGCTTGTCAGATGCACGTTGCTGAGTTT

AACCTCTAAAAACAAACCCATGACC CTGGATCATTAAGTCTTGGGTAGTACTCA AGAATTTGCATTTTCAATAAGTTCCCAGA TGGTGCTAGGGCAAACTTATCCACTAGG CACAGTAACACAGCACCTAAAAGTTGGA CACTAAAAGTCCAATTTACTTTTAGTGAA CCATGAAAATAGTTTGATTTTAATCTCTCT TCAAATCAGAATAAAATAATGAATATGAT AATAATGAATGTATATGAGGAATCCAACC TAGAATATATTCATCTTTATATTAACGCAG TATAAAAATATTAATTCTATTTGTTTATGT ATTTCTAATGAAGGAGGGGACATGTGAA GGCAAAAGG rs4884057 13 76310078 CTGGGGGAAAAAAACTATATTCTGCCAC C/T TTTTGAGGTTGTGAGCCAAAGGAACAGC SEQ_0656

CAGCAGAAAGATGAATTTTGTTGGCCTTT AAACACCATTCTGTGTTTAATAAGCCTTA

GAAAGTCAGAGGATTAACTAGTGTTTGG TACTCTCCAGTATTGAGATTACCCGTGAC

GGGGAAATGTTTTAAAAGATACAGAACCT AGAGTTAAAACTTGGTGGGGAAAAAAAA

GTCTTATTTTCTGCTTCATGAACTAGTAA AMGTTATTCCAAGCCACTGGCACAACAT

CACAAACACTGGAGAGGCTGTGATGGGT ^• MGATCCTGCCATTGTAAAGGAATCACAT

GTGTTCCAGCTGTCTGCTAACAGATGAG GGATTGTGAAGGAAGCMTTGTGAAAGA

G

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9544383 13 7631 1981 AGGCCATGACATGACCAAAAAAACTGCC OU TCCACAATTGGATCACACTCTTCAAGAGC SEQ_0657

TAGGTCTAAAATTTTCATAAAGTGCAATC TCTCTCTATCAGGTAAGGGCTTGGGCAA CTCGCAGAGCAAACCAAAAGTTAATTCTT TGCCTTTTACAGGCTGACTCCAAATTACC TGGTTTAAAAGTCCCCTCTTATCCCTTTT TCTCTTGCCTCACCTCTGATAACACCCTA ATATAAGTGAAATTATGTAACCAAAAAATT CCACTATCACCCACTGAGTTTCACCAACC ATAACTAATAAGAAATATGAGTGTTTCAT CCACCCACCTACACTCACAGCACTACCT GTTTATTCCGTTTCCATTGAATTTGA ATTTCTCCAAACTGATACTGATGGAGGA rs2876711 13 76314505 CAAGAGATCAGAAAAAACAAAAATGAAAA CΓΓ CTGGGGTGTGGCAAGGAGTCAAGGCCA SEQ_O658

TGCAAAGATTTTAGAGTGAAGCAAATGAG CAAAGCACTGAGAAGCCAGTTGATCCTA TTTGAATACTAACTCTTACTATTTCTAGCT TTATGCCTTTGGTGGCACCAGTCTATTCG ATGTGAGCTTGGGCAAATTATTTAATTCT GTGGGGAAATTTTCTAATCAGCAAAACTC TCTAAGTCTCAGTTGCTAATATATAAAAT AGGTGTGGAAGACTGACGTCTGGATTCA GGAGATAACAGAAATGTATATAGCTGCTT TCCAGGCCTGGGATTTTGTCAAGCAGTA TGAATAGTAAATGAGATAAACAAGGTAAG GTGAAAGAAGTTACATAGGGACAAAAGA GTGTTTAGCATAGTGCTTAACACATAAGT GTTGATAGTGACAAAAGAGAGACTGAAG ACTTAACAAACATTAGCCATATAGTCTTC TGATAGAACACAAAATCTAAACAGATTGA CTTCAATACACGTATAGCACTCATGCAAG GAAATGGATTGAAGATGCAAGGTGGGTG AGATATTTATAGACATATTCGTGAGTGAC ACAGAGAAAGAAAAAGTAAAGTAATTGAG AAGCACTCTACTAGATGCTGAGGATACC GGTCTAGAGAGCCTAAAGAGACAAAGAG ATGGGAAAGAAAGATCAACACCATCCCT TAAGATGGATATGAGGCTATGTTCAGAG GCCCTCATGGAGCTTACTGTCTACTAGT AGTAAATGTCTGAATATAATAATTGAGTA GCTGGCAGACAATTAAATGAACAGTTACA ACCAAAATATGGGTACGGAGTACCATGG ATTCAGTAGAATAAACAATATTTCAATGC CCAGAGTATGGCCATGGAAAAAGAAGAG TGTTGGTAGGGAAGCTCACAGGGCAAGA GAACAGGGTTAGAGCAGAAGAGGGTTAC ACTAACCAAA GAGTAAGTCAAAACCCTGAG rs8020475 14 64723761 TGGGACCTGCCTGCTTTTATGCTGCTTAA C/T TTTTGGGAAGTAGCAATGCTGTAGAAAG SEQ 0659

GTCTGAATCACAAAACTGTGAGCCCCTG GAAGAACAGTAGAGACACTCCTCGATAG GAGAGCGGGGCAGGCTTAATCCTATTTT TTACAAGGGGAGATGAAGCCTTGGGTCT TTTTAATCCCCTGAGATGGGTTAGTCCTT GATCTGTCCCACATTAGATTCCCATTTGT TGCAGGCTATATTTGTTAAAATGAATTGA AGAAGAAAAAAAGAGAAAGGAATGAAGC AATCAGGAGTGTAAGAC I I I I l I I l I GAA TACATCTCCCTCATCAAGTTAGCCTGGG GGCTTTGTTTCTTTTTCTTGTCTGATGC GGGTCTGCCGCAAAGAGGATTGAAGGG GAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1679885 14 54772712 GGCCAACACGGTGAAACCCCATCTGTAC A/G GATCACGAGGTCTGGAGGTCGAGACCAT SEQ_0660

TAAAAATACAAAAAATTAGCTGGGTGTGG CCTGGCTAACACGGTGAAGCCCCGTCTC TGGCGGGTAACTGTAATCCCAGCTACTC TACTAAAAATACAAAAAATTAGCCGGGCA GGGAGGCTGAGGCAGGAGAATGGCGTG TGGTGGCGGGCGCCTGTAGTCCCAGCT AACCTGGGAGGCAGAGCTTGCAGTGAG ACATCAGCTCCCAGGAATGCTAAGGAAG CCAATATGGTGCCACTGCACTCCAGCCC CAGGGTGATGTGGGGGAACGGAAAACA AGGCGACAGTGCAAGACTCCGTCTCCAA CGCCCAGGCCCAGCACAGCCACCAGCT AAAAAAACCAAAAACAAAACAAAACAACA GTGGGCATGTGACCTGTGCTCAAACCCT ACCAGAGAAAAAAGACACAGAAAGCAAA TCTCCTTTCTAGGCCTGTTTCCGTCTCCA TCAGAGGTTGCCCGGGGTGGAGAGATTA GTCGAGGAATCTCTGTGGACTTACTCCA TGACGCAGGTGTTCCATGTCTTCACAGC TTCAGAACATTTATGACTCCGAGAGGAA AGTGGTAATGGTGGTGGTTGTGGTGTAT GCCGATGTACTACTTCTCTTGGAGGGTG GTGTGTTTGGATTTTAGAAATCATTAGTT ACGTGGGAAGGTCCATCTCCAGATGTGG CATACTAACACATCCAGTTCCAATCTAAC CCTTATTTGGCTAGCCAATGCAATG CCACCCATAATTATATCTTCCCTCTTCCA TAGTTAAGAACTCTGGCTCCGGCCGGGC ATGGTGGCTCACGCCTGTAATTCCAGCA CTTTGGGAGGCTGAGGCAGGC rs 12586596 14 64783067 AAACCTTTTCATCTGGGCTAATGTTCTTT C/T AGAACAGCTAAAAATTAAGCTACCTGTGA SEQ_0661

CAAATTGGAGCACCTTACCTTCATCTCAA CACCAAATGTTGATGAGGATGTAGAGCA ATTAATGTTTGTGTATAGTGTGAAATGAC ACTGGAATGGTCATAGACCACTTTGAAAA AAAGTTAGTTATTAAGTGATAAAGCTTCT GCAGTTTGGGGCGGGGCACGGTGGCTC AGAAGAAAACAGGAGAATATCTTCACAAC ACACCTGTAATCCCAGCACTTTGGGAGG CTTGGAGTAGGCAAA I I I I I I CTTAGGTT CTGAGGGGGGCGGATCACGAGGTCAAG ACAGACAACAATAACTACAAAAGACAAAA AGATTGAGACCATCCTGGCCAACATGGT AAATCAGACATTTTCAAAATTAGAAATGT GAAAACCCATCTCTACTAAAAATACAAAA CTGTACCCTTAAGAAAATGAATAATAGGC AAAGTAGCCGGGCATGGTGGCGCTTACC AATTCTCAGACTGGGAGGGAGTATCTAC TGTGGTCCCAGCTACTTGGGAGGCTGAG AAAACAAATAATGTTATTAATAAAATAGCA GCAGGAGAATTGCTTGAACCTGGCAGGC TTCCTACAACTTAATAATAAGAAAAGCAA AGAGGTTGCAGTGAGCCAAGATTGTGCC CCCATTTTTAAAAAGTGGGCAGACACTTT ACTGCACTCCAGCCTGGCAATAGAGCGA ACAAAGGAAGATATAACAATAACTGATAA GACTTCGTTTAAAAAAAAAAAAAAAGCAG GCACATGAACAAATGCTCAACATCACTAG TTTAGTAATTTCTTACAGTTAGACAAACA CTAGCAGGAAAATACAAATTGAACAAATG CATACTCTGCAACCCAGCAATTAAATGTC CTCAACATCACTAGCTAGCAGGAAAATAC TAGGTATTAACCCAGATAAAGAAAAACAG ACATCCA GCCAGGTGTGGTGGCTCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs11158584 14 64784735 GAAGATAGTCAGCTTAAGAGAGCAAATT G/T TAACTATATGTAAATACTATGACATAAAGT

CTCTCTTACTCAGCCTTCTGTTCTCTTCC CAATACTTTG I I I I I I I G I I I I I I I G I I I I I GGCCTTTAATAGATGGAATGAGGCCCAC AGACGGAGTCTCGCTCTGTTGCCCAGGC CCATATTGGGGAGGGCAATCTGCTTTGC TGGAGTGCAGTGGCGTGATCTCAGCTCA TTATCTATCAATTCTCATGTTAATTTCATC CTGCAACCTCTGCCTCCTGGGTTCAAGT CCAAATCTCTCCCTTGCACACACACGCA GATTCTCCTACCTCAGCCTCCTGAGTAGT CACGCGCACACACACACACACACACACA TGGGATTACAGGTGCACACCACCCACAC CACACAATAATGTTTAACCAAATATCTGG CCAGATAA I I I I I I I GTATTTTAGTAGAGA GCACCTTGTAGCCCAGTGAAGTTGACAT CAGGTTTCAAAGAGAAGAAAACAAAGATA AAAATACTAGCCATCACAAGTCCATCAAC TTTCTCTACAAAGAGTAGAGAAGAAAACA TAATCTCATCAACTTGGCACCTATATGTA AAGATATTTGCTTAGCGTATATGTGGATA TCTCCTTAAGCCATACTTAATCTCCAAAT GATTTATACACACAAATATACACTCACAA AAAGACACTAACAAGGCTGTAATTCCACC ACATATTAATAACAAAATAAAGAGGAAAT TAACCTGATACAGCTATTCTGTGTATAAC GCTCATGACAATTACAGCCCTCTGGCCA CAAAACACACTAACCCCCTCCCCAGAAG GGCACGGTGGCTCACACCTGTAATCCCA AGGAGCTAAAGTCCTTCAGTGATGTATAC GCACTTTGAGAGGCCGAGGCAGGTGGA TTTCTCTATGAAATCCTGTAACTTAAATAC TCACCTGAGGTCAGGAGTTTGAGACCAG TATGGTATAAAA CCTGGCCAACAT rs12100912 14 64786391 GAAGGGTCTGAGCCAGTCATAGTCCTGC C/T GCTGCAGACCTACAAAGTATTGCCGCTG SEQ_0663

CCGGATTGGATTGTTGTAGTTTTCCATTG AGCTGGCACTGTAACTGAGTCTTCAAAA ACCTTAATCACAGGACATGCTTTAAGGGA GGCCATTCCATTGTACTTTCAAACCAGCT TCACTTGTGTTCCAGACAAACTCTTCCTT GCTTCAGGATGGTGTGGAACACGGTAAG TTCTCCACTGTGGAGTAGCAGTCCAATTT ATCAGTGAATTTCATGAGCATGGGCCCA CCCCTAGGTAGTCAGGATTAATTATGCCA CTGCTGCACTTCTTTTGCTGTGAAGTGAG GTCGGCACAGTAACTCCCTTCTTTGCCT CTCCCTGATTGAAAGCAATGCTGTGTGTA GTTGATTTGGAGGCATAAGGAGTCCAAA ATACTATGACGGAGGATAAGACATTCCAT GTGGCCAGGTGGCAGTCTCAACTTCCAG AAGTCTGCGGATAGTAGTTTTGGCAGAA TTCAATAGAATCATTGTTGTGTCTCCTGG GCATTGCATGCAGGGAAGGCAAATCCAT TGGAAACATTCCTCCCTTCAGAACTAAGA ATTCAAAGTGTCTATTCCAATAAGAACAA CCACTAAGCCAGCAGAGCATAAGGTCAT AATGCTGCCCTTTCCATAATGGAAGCCAT GAGAATAGGAAGCAAAAATTTTGCTAGTG CCAATGTAATCAGCCTGCCTCCGGGTAG GGGCACTAGTGATAATAGTGGGTGTTTC CTGTTTGTTTAGCTGGAGGAACAGTGGC ■ TACTCTATGATTCCTGGAGCTGTGAATCT ATATCAGGGACTCAGTGTCGGTCTCTGA TGGCTATGGGAAGAAGAACACCATACAT TGCTGGCAAATTGAACACTCAGTGGTGG TGGACTCTGGTTCAGAGCATATATACAG CTGTAGCCAAATCAGCCTTGGTAAGTGC CCTTCTGGATAACCT AGTCCATGTTGTTGAGCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1256511 14 64804244 ACACTGCAGACTCTTCCAGTTTTGCCATT A/T ATCAGGGCCTGCTCAAGGGCACATGGAT SEQ_0664

ATAACACTCGCGGAGCATTCC I I I I I GAA GTGTTGGCGGGTGTGTGTGTGTCGTGG CAGTACCCATTCCCTTGATGTCTACGATA GGGGGACTGGGTGATGGGGAAAGTGGA TCTACGATATCACCTTTCTTTCCTTCTTTC AGCATGGCGAAGTGGAGAGAGAAGAGG TTTCTTTCTTTCTTTCTTTCTTTCTTTCTTT ATATGGGAGTGAACAGATAAAAAAGAAA

CTTTCTTTCTTTCTTTCTTTCTTTCTTTCTT CATTTAAAGGAATCATTTTGGGGGTTAAA

TCTTTCTTTCTTTCCTGCTTTCTTTCTTTC AAAATAACTCTAGGTTTGAAGGAGTATAC

TTTTCTCTTTCTTTCTTTCTTTCTTTCCTTC AATTT

TTTCTTTCTTTCTTTCCTTCTTTCCTTCTTT

CTCTTTCTTTCTTTCTΓΠTCTTCCTTCCT

TCATTCCTTCCTTCCTCTCTCTTTCTTTCT

CTTTCTCTATTTCTCTCTTTC I I I I I I I I I I

I I I I I I I I I I GAGACGGCGTCTCGCTCTG

TCGCCCAGGCTGGAGTGCAGTGGCGTG

ATCTCGGCTCACTGCAAGCTCCGCCTCC

CGGGTTCACGCATTCTCCTGCCTCACCC

TCCGGAGTAGCCGGGACTACAGGCGCC

TGCCACCACGCCCGGCTAATGTTTTGTA

I I I I I AGTAGAGACGGAGTTTCACCGTGT

TAGCCAGGATGGTCTCTATCTCCTGACC

TCGTGATCCGCCCGTCTCGGCCTCCCAA

AGTGCTGGGATTAACAGGCGTGAGCCAC

CGCGTCCGGCCGATATCAACTTTCTTATA

GATTCGCATACATGTGGCCAAAGGAACA

ACTCCATGTTTTCTAAAGGGCCTAGAGAA

CATATATCGGGTGCCTCTCCTCTTTCCCT

TTGTGTTCGTCATTTTGGCGAATTACTGG

AAGATGGCGGTTCTGGCCAAAAGGAAGG

AGCTATTTTAATTTTTATTAGGCAGAGGC

AGAAATGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1256513 14 64804888 AAGGAGTATACAATTTCCCGAGACTTCAT AJT TTGTATTAGGGCCCACTCTAAAGACCTCA SEQ_0665

AAAGTCCTGCCAACTTCTTCCCTCTAGCA TTTTCACTTAATCATGCCTTTAAAGAACTT

AAACCTGTTTCCGTGTGTTATCAGTCAGT ACCTCCAAATACAGTTACATTCTAAGGTA

TGTGCCTTGTTCTGTAATCTCAATCACAC ATACAGGTTAGGACTTCAACATAGGAATT

AGCGCCCAGTAAGAACAACAAATGCATT TTATGGGGACACGACTTGGCCCATAACA

GCACAAACACATCTTTGTGGTAACACCAC LAATGTTTAGACACTGTTCATTCTATACTG

AATGAAGAATTCTGTAAGAAACATGGAAT CATGAATATGACCCCAGTCACACACTTAG

GAGTTTGCTAGGGCTGCCACAAGAAAAT ATATTAAGGGTATCTCCTTATTGACCCCG

ACTACAGACAAGAGGGCCTAAACAACAG AGAGGTTTTATTATCTACAGAAATTGACT

AAATGTGTTTGCTCGCAGTTCTGGAGGC GTCATGCCTTGGGCTGAGAGTTTATCAG

TAAAAGTCCAAGCTCAAAGCGTGGTAAG ATGAAATGCCTTTGAAAGAAAGTATTGAT

GTTTGGTTTGTTCTGAGGCCTCTCCTTGG TCCTCCCTTTCTTGTTAGGCACGAGCC

CTTGCAGATGGCCACCTTCTCGCTGGGA

CCCCACAGGTCTTTCATCCATGCCTGCG

AACATGTCTGTTGTCTCTCTCTCTGTCCA

AATTTCCTCTTCTTATAAGGATACCAATC

AT rs1256515 14 64805110 TATCAGTCAGTTGTGCCTTGTTCTGTAAT CfT ATTGACCCCGAGAGGTTTTATTATCTACA SEQ_0666

CTCAATCACACAGCGCCCAGTAAGAACA GAAATTGACTGTCATGCCTTGGGCTGAG W

ACAAATGCATTGCACAAACACATCTTTGT AGTTTATCAGATGAAATGCCTTTGAAAGA

GGTMCACCACAATGAAGAATTCTGTAAG AAGTATTGATTCCTCCCTTTCTTGTTAGG

AAACATGGAATGAGTTTGCTAGGGCTGC CACGAGCCAGGTGAAGCAAGAATTGCAG

CACAAGAAAATACTACAGACAAGAGGGC ACCCCAAACTTCCTGTTTTCATCGTGTAG

CTAAACAACAGAAATGTGTTTGCTCGCAG AAAGCTCTATTGCAAATATGGTCAATGT

TTCTGGAGGCTAAAAGTCCAAGCTCAAA

GCGTGGTAAGGTTTGGTTTGTTCTGAGG

CCTCTCCTTGGCTTGCAGATGGCCACCT

TCTCGCTGGGACCCCACAGGTCTTTCAT

CCATGCCTGCGAACATGTCTGTTGTCTCT

CTCTCTGTCCAAATTTCCTCTTCTTATAA

GGATACCAATCATTTTGTATTAGGGCCCA

CTCTAAAGACCTCATTTTCACTTAATCAT

GCCTTTAAAGAACTTATCTCCAAATACAG

TTACATTCTAAGGTAATACAGGTTAGGAC

TTCAACATAGGAATTTTATGGGGACACGA

CTTGGCCCATAACAAATGTTTAGACACTG

TTCATTCTATACTGCATGAATATGACCCC

AGTCACACACTTAGATATTAAGGGTATCT

CCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1256516 14 64805292 ATATTAAGGGTATCTCCTTATTGACCCCG CfT TGCAAATATGGTCAATGTGCCTAAAACCA SEQ_0667

AGAGGTTTTATTATCTACAGAAATTGACT GAAGAGCTTTCTGTAAGAAGTGTGGCAA

GTCATGCCTTGGGCTGAGAGTTTATCAG GCATCAGCCTTACAAAGTGCCCCAGTAT

ATGAAATGCCTTTGAAAGAAAGTATTGAT AAGGGCAAGGATTCCTCCTATGCCCAGG

TCCTCCCTTTCTTGTTAGGCACGAGCCA GGAAGATGCGCTGTGATCAGAAGCAGAG

GGTGAAGCAAGAATTGCAGACCCCAMC TGGCTACGGTGGGCAGACAAMCTGATT

TTCCTGTTTTCATCGTGTAGAAAGCTCTA TTCTGGMGMGGCTGAAACTACCCAGA

TGATTGTGCTAAGGCTGGAATGTAGGGA

GCCTMCTGCAGAfCCMGGGGATGCTA

GCCATTCAGAAATGCAAAC I I I I I I I I I I I

TTTAAGACAGGGCCTCACTCTGTTTCTCA

GGCTGGAGTGCMTCATGGCTCACTGCA

GCCTTGACCTCCCTAGCTCAAGCAATCC

TCCAACCTCMCCTCTCGAGTAGCTGGG

TCT rs1256517 14 64805437 TGAAGCAAGAATTGCAGACCCCAMCTT C/T TACGGTGGGCAGACAAAACTGATTTTCT SEQ_0668

CCTGTTTTCATCGTGTAGAAAGCTCTACT GGAAGAAGGCTGAAACTACCCAGATGAT

GCAMTATGGTCAATGTGCCTAAAACCA TGTGCTMGGCTGGAATGTAGGGAGCCT ^

GAAGAGCTTTCTGTAAGMGTGTGGCAA MCTGCAGATCCMGGGGATGCTAGCCA £

GCATCAGCCTTACAAAGTGCCCCAGTAT TTCAGAMTGCMAC I I I I I I I I I I I I I I A

AAGGGCAAGGATTCCTCCTATGCCCAGG AGACAGGGCCTCACTCTGTTTCTCAGGC

GGAAGATGCGCTGTGATCAGMGCAGAG TGGAGTGCAATCATGGCTCACTGCAGCC

TGG TTGACCTCCCTAGCTCAAGCAATCCTCCA

ACCTCMCCTCTCGAGTAGCTGGGTCTA

CAGGTACACATCATTATGCTTGGCTAACT

TTATTTA I M i l I GTAMGGTMGGGCTC

MTATGTTGCCCATGCTGGCCTTGMTCC

CTGGGCTCAAGTGGTCCTCCCACCTCGG

CCTCCCAMGCACTGGGATMTAGGTGT

GACCCACCACACCTGGCTGGGA I I I I I I

GGTGGTGTTTTTTTCATTTTGAGGAGAAA

AGGTTGAAGCTATAGAAAAATTACCTGTT

TGTACCCCAACCCTTAGCATCTTGCMTC

TACACAGGTMCGMGCTGCACATGTAC

CTGAATCTAAMTAAMGTTGAAAAAGM

MAMGAAAMTCACCAGTAGGAAAATAC

AGTGATATTCTTACTTAAAAAAAAAATCCT

ATGCTGACTTAAAGAATTTTGMGGTCCC

GTTTCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1256519 14 64806077 TGGAAGAAGGCTGAAACTACCCAGATGA A/G AGAATTTTGAAGGTCCCGTTTCTCCTTCA SEQ_0669

TTGTGCTAAGGCTGGAATGTAGGGAGCC AATTGCC I I I I I GTCTTGTTTATACAGGA

TAACTGCAGATCCAAGGGGATGCTAGCC ATTAATTTAGATGGGAGGTCCTGAAAGG

ATTCAGAAATGCAAAC I I I I I I I I I I I I I A GTTTGCAATATTTGCAGAAGCTACTAATG

AGACAGGGCCTCACTCTGTTTCTCAGGC CTCTAGAAACAGGTGCAGTGGCTGAGCA

TGGAGTGCAATCATGGCTCACTGCAGCC TGGGCTGAAAGGAGGTAGCAAGGAGAG

TTGACCTCCCTAGCTCAAGCAATCCTCCA ATCACTGGTCAAGGTAGAGAGGGTGGGT

ACCTCAACCTCTCGAGTAGCTTGGTCTA GA

CAGGTACACATCATTATGCTTGGCTAACT

TTATTTA I I I I I I GTAAAGGTAAGGGCTC

AATATGTTGCCCATGCTGGCCTTGAATCC

CTGGGCTCAAGTGGTCCTCCCACCTCGG

CCTCCCAAAGCACTGGGATAATAGGTGT

GACCCACCACACCTGGCTGGGATTTTTT

GGTGGTG I I I I l I I CATTTTGAGGAGAAA

AGGTTGAAGCTATAGAAAAATTACCTGTT

TGTACCCCAAACCTCAGCATCTTGCAATC

TACACAGGTAACGAAGCTGCACATGTAC ^

CTGAATCTAAAATAAAAGTTGAAAAAGAA £

AAAAAGAAAAATCACCAGTAGGAAAATAC

AGTGATATTCTTACTTAAAAAAAAAATCCT

ATGCTGACTTA rs1256520 14 64806946 TTAG CTACTAAAAAAAATGATTC AAAAAA A/C CATTCAAATGAATCAGAAATATGAATTTTA SEQ_0670

ACATAGTCCCTTCCTTCCAAGCAGAGAG GATCTTCCTTTAATGACCTGAGTAGTGAA

GTCCCTAAAGGGTCACAACCAGTAAATC AAACAAGAAAAAGCATTGTTTACACATGA

TCTTTCAGTCTCCAGAAAATGACTTAAAA GTTGATAAACCACTTGGGGATAAGAAAC

GATTGTAGGTTGGGTGTGGTGGCTTATG AAGATGTGTACTCTACAGCCCCGTGCAT

CCTGTAATCCCAGCACTTTGGGAGGCTG TCTTTGCATGAAGCAGATACTCGATATAT

AAGTGGGAGGATCAGTTGAGTCCAGATG ATTCACTGATTGGATCTGAATCTCCAA

TTTGAGACCAGCCTGGGCAGTAGTGAGA

CCTCATCTCTACAGAAAAATTAGCTGGGC

CCCCATGGTGGCATGCGCCAAGAGGCT

GAGGCAGGAGGATTGTTTGAGCCCAGGA

GGCAGAGGTTGCAGTGAGCCGTGATTAT

TCCACTAAACTCCMCCTGGGCAACAGA

GTGAGACTCTGTCCCCCCTGCTCTCCAG

AAAAAGATTGCAGTTTAAAACTTTTATGA

ACTGAAGTAAAACTCCTTCCTATCTCCCC

ATATGCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ IP rs 1256525 14 64808303 AATAGCCACCACTTGAACACTCTMGAAG C/G TGATATGCATTCTTCAGTGTGAAGAATCC SEQ_0671

AAAAGAATTTAATTCAGGAAATTAGGTGC TACCCACTAGTCTATTAATGGAACACTCC

TTAAAAATTCACTGGTAGGCTAAAGGAGC TGCCCCTGTTCCCTCCCACCCCTCACTC

AGGTCCTAGGCTATGTTGCCAGCAATAA CGTCCCAGGAGAGGTAAGTGAGGTATCT

CCAGCAGAACATTGCAGAAATGTCTGCT GACTGGCAAGTGTAGAAGAAGAAACTTG

AAAGAAGCTGCTACCTGTGTCCCCGTCA ACATGCATGGACCAATCCCCTCCTCTTCT

AGAAGGTGAAGGGACCAGGAAGCCACC CTTTTCTGCCCACAGGGAGTATGCTTTCT

ACAGTAGGTGTGGCTCCAGAATGACACC

TGTGGAAGTCCAGTGCCCCTGTGCCCAT

ATTTGCAAGGAAACAGCAGACAACACAG

ACCACAGCCTCCTTCCAAATCTCMGCA

GGTACAA

κ>

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEC rs1256526 14 64809658 ATGGGCATTATTAGCTGAGGAGCTAATG G/T TTTGTATGTCTTATATACTTATATACAATA SEQ_0672

CTGCAACTCTTAATGTTCATAACCTGTTC AAGTATATATGCTTATATACAATAAAGCTT CATATCATGATACACATAGGAAACGGAAA ACTTATATACAATAAAGTAAGCTAGAGGA AAAACATTTATGTGCACACACACACACAC AAGAAAATGTTATTAATTATAGGCCTTGC ACACACACACACATATCACACTATGGAAA ATGGTGGCTCACACCTGTAATCCTAGCA AAGTATGAGGCTGCTGGCACCAGAGGTA CTTTGGGAGGCCAAGGCAGGAGAATCAC ATTAACCCAGAGGTTCTAGCTGCCCTAG TTGAGTCTAGCAGTTTGAGGCCAGCCTG GCCTTGCATTGAGAGGATCAATATCTTAT GGCAACACAGTGAGTCTCCATCTCTACA CATACCTGTAACCCACTCCCTGGCCACC AAATAAAAAATAATTGACTGGGCACGGTG AGTTAGGAAGTTCTGGCTTGGAGAAGTG GCCCAACACTTTGGGAGGCTGAGGTGG TGCTAATTAGTTCAAGGCCACAAGGTTAA GCAGATCACCTGAGGTCAGGAGTTTGAG TATATTAGTAGTTGATCCTTGAATAACAC ACCAGCCTGGCCAACATGGTGAAACCCC AGGGACAAGGGCACCAACTCCTGTGCAG GTCTCTACTGAAAATATGAAAATTAGCCA TAAGAACTTCACATGTAACTTTTAACTCC GACATGGTGGTGGGCGCCTGTAATCCCA CCCAAAACTTAACTACTAATGGCCTACTG GCTACACGGAAGGCTGAAGCAGGAGAAT TTGACTGGAAACCTTACCAATATTATAAA TGCTTGAACCTGGGAGGCAGAGGTTGCA CAACCAACTAACACATA GTGAGCCGAGATAATGCCACTGCACTCT AGCCTGGGTGACAGAATGAGACTCTATC TCAAAAAAAAGAAAAAAATTAAAAAAATAA ATAAATAATTAGCTGGGTGTGGTGTTGTG CACCTATAGTTCCAGCTACTCCAGAGGC TGAGACAGAAGGATCACTTGAGCCCAGG AGTTCAAGGCTGCAGTGAGCTATGATTG TGTCACTGCACTCCAGCCTGCATGACAG AGCAAGACTCTGTCAAGAAAGAAAGGAA GGAGGGAAGGAAGGAAAAAGCGAAGGA AGGAAGGAAGGAAAATGAGGGAAGGAA GGAAGGAAAAGGAAGGAAGAAGGGAAG GAAGGAGAAAGAGAAAATATATTTATATT CATTACATGGAAGTGGATCATCACTTCCA CTTCATCCTTATTATGTTCATGTTAAGTAG GCAGACTGAGAAGGAGGAGGAGGAAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6499749 16 53749781 ACAGTCTCAGTCTCCTGCACCCAGAATG A/C TCCTTCCTCACAACACTCTAGCATCTTCT SEQ_0673

GTCTCTCTGCTCTGCTTCCTCCCATGCC TGTCATCACATCCCCTCTAACTCTCTCCT

CACTTGCCCTTGTTGAGGTCTAGCTCAT GCCTC I I I I l I AACAGGAACTTCTGATGA

GGCCCACCATTCATATCTTGGAGGCTCC TGTTGGGCTGGCTCTCCCCATTTTAAGAT

TCTGATTCCGAGTTCCTAGGATAGAGGA CCTTAACCTAATCACATCTGAAAAGTCCC

CCGCACAGAGTTGCTCGGTGGAACCCTA TTTGCCATGTGAGGTAACATAATCACAGG

TTCCAGGAGACACTGCTACAGGCAGTAC CTCAGGGATTAGGATATGGATTTTAGGG

TATATAGTATCGTGGTTGAGTTTAGGCTC GACGGGGCTGTTCTTCAGTCTACCTCAG

TGGAGCCAGATGGCACAGGACCACATGC TATATATAAATTTAGGTGAGTTAAACTCA

TAACTCTACCGCTTTCTGACTACGTGTAT GTTGCCTTATCTATCAAATGGCAATAACA

GTATTAGTTCCCCATTGTTGCTGTAACAA ATTGCCTCTAACTTCAGAGAGTTGTCTTG

GTTGCAATACATGTAATAGCTTAAAACAA AGAATTAAAAGATTTAATACGTATCAAGG

CACAAATGTATCATCTTACAGTTCTAGAG CCTCAGCCAGTGCCTGGGTCATAGTAAA

CTAAGTTTAAAATCAAGGTGTGGAGAGG CGCTCAATATATGTTAGCTCTTCTTACTG

TCTGCATTCCTTCAAGAGGCTTGAGGGG TCATACTGTAAAATAAGGGTTCCATGGCC

AGAGTCTGTTTCCTTGCCTTTTCCAGCTT AATGAAGTTTGAGAAAGGCAGCATACTG

CTAGAGACCGCCTGGATTCCTTGGCTCC CATCTGCATCTTGGAGATTCGTGATGCC

TGA CCTCATTGTGTTAAAGGCTTTGATAAATC

TTGCAGAAATAAAGGCTCCTGGTGGCTA GCTCAGCATATGAATGTATTTGACCTTCT AATGAAACCATTTCTTCCACAAAGCATCT ATTTAGATCCTCTATATTTAGAAGTTGGG rs4783883 16 53750132 ACAACACAAATGTATCATCTTACAGTTCT A/G GCCAGTGCCTGGGTCATAGTAAACGCTC SEQ_0674

AGAGCTAAGTTTAAAATCAAGGTGTGGA AATATATGTTAGCTCTTCTTACTGTCATAC GAGGTCTGCATTCCTTCAAGAGGCTTGA TGTAAAATAAGGGTTCCATGGCCAATGAA GGGGAGAGTCTGTTTCCTTGCCTTTTCC GTTTGAGAAAGGCAGCATACTGCATCTG AGCTTCTAGAGACCGCCTGGATTCCTTG CATCTTGGAGATTCGTGATGCCCCTCATT GCTCCTGACTCCTTCCTCACAACACTCTA GTGTTAAAGGCTTTGATAAATCTTGCAGA GCATCTTCTTGTCATCACATCCCCTCTAA AATAAAGGCTCCTGGTGGCTAGCTCAGC CTCTCTCCTGCCTC I I I I I I AACAGGAAC ATATGAATGTATTTGACCTTCTAATGAAA TTCTGATGATGTTGGGCTGGCTCTCCCC CCATTTCTTCCACAAAGCATCTATTTAGA ATTTTAAGATCCTTAACCTAATCACATCT TCCTCTATATTTAGAAGTTGGGAAAACTT GAAAAGTCCCTTTGCCATGTGAGGTAAC GGCCCAGAAGTTTTCTGGTACTTATACAA ATAATCACAGGCTCAGGGATTAGGATAT GTGACAGCAATCAACAGAAGAGTACCTG GGATTTTAGGGGACGGGGCTGTTCTTCA GCAGAGGCAAAGAATGCAAGTTTCTTTA GTCTACCTCAGTATATATAAATTTAGGTG CAGGCCCCAGCCCAACACATGTGT AGTTAAACTCAGTTGCCTTATCTATCAAA TGGCAATAACAATTGCCTCTAACTTCAGA GAGTTGTCTTGAGAATTAAAAGATTTAAT ACGTATCAAGGCCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12929336 16 53753320 ATATTTAAGGGTATAATAATAGTACCTAC A/G CTTAACATTACACTTAATGTCTTCC I I I I I SECL0675

TTGATATGGTTAGACTTTGTGTCCCTGCC GACACCATTAGGATTCTTCACATATGTTT CAAATGTCATCTTGAATTGTAATCCCCAC CTCTGAGCTTGCAAAGTGTTCCGATAATG AAGCTCCGTAATCCCCATGTGTCAAGGG AGTGCACAGTAGTCACTTGAGAAAAGCC AGAGACCAGGTGGAAGTAATCAAATCAC CAGAAAACCAGAGGCAAAGGGTGAGGC AGGAGCAGTTTCCCCCATGTTGTTCTCG CTCTTGGTGGTGGTACAGGCTGCTCCTG TGGTAGCGACTGAGTTCTCATGAGATCT GAGCCCTTCTTTCAGGGTCCTATTTTCCC GATGGTTTTATAAGGGGCTCTTCCTGCTT TGCTTGGCACTTCTTCCTGCCACCTTGTG AAGAAGGTGTCTTGCTTCCCCTTCCCCTT CCACCATAATTGTGGGTTGCCTGAGGCC TCCCCAGCTATGCTGAACTGTGAGTCAA TTAAACCTCTTTCCTTTATAAATTACTCAG TATCAGGCAGTTGTTTATAGCAGTATGAG AAAAGACTGATATACTACCATATAGGGTA GATGGGAGGAATAAATCTAAAAAGTCTTG GAATAGCACCTGGCACATAGTAAACACT ATGAAATA I I I I I

4- 4- rs12930690 16 53753511 TGAGATCTGATGGTTTTATAAGGGGCTCT C/G TATTTTCCCTCGTGTGACACTGCAGCAAG SEQ_0676 Ul

TCCTGCTTTGCTTGGCACTTCTTCCTGCC AGCTTCTCAGGGAACATCCCCCACACAC ACCTTGTGAAGAAGGTGTCTTGCTTCCC ATACTTCCCCAACCCTCATCTCCCACCCT CTTCCCCTTCCACCATAATTGTGGGTTGC GCAATGGATACTGTAGCTGCTGTGCCCA CTGAGGCCTCCCCAGCTATGCTGAACTG CATGCCCTGGGCCCCTTTTACCAATTCT TGAGTCAATTAAACCTCTTTCCTTTATAAA GCGAGCTCATCCTCCCCTCTCTCCTGTTT TTACTCAGTATCAGGCAGTTGTTTATAGC TGCTGCTGACAGCTAGAAGATTCCAGGC AGTATGAGAAAAGACTGATATACTACCAT CAGCCATTCTCTAGAAATCCCTTATCCAG ATAGGGTAGATGGGAGGAATAAATCTAA GATTGTTTGACGTTTCCCTTTGATTAAATT AAAGTCTTGGAATAGCACCTGGCACATA TAGGTTATTCATTTTTGAGGGAAAATAGT GTAAACACTATGAAATA I I I I I GCTTAACA AGTTTCA I I I l I I I ACATGAAAATATTGAA TTACACTTAATGTCTTCC I I I I I GACACCA TCCGTTTGG TTAGGATTCTTCACATATGTTTCTCTGAG CTTGCAAAGTGTTCCGATAATGAGTGCA CAGTAGTCACTTGAGAAAAGCCCAGAAA ACCAGAGGCAAAGGGTGAGGCCTCTTG GTGGTGGTACAGGCTGCTCCTGGAGCC CTTCTTTCAGGGTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs982601 16 53757536 TGTGCATTTATTCTATAAGCAGAGATATT A/G AGTGGGCTGCATTGAGCAATGGACCAGC SEQ_0677

ATACCAGTCACTACACTTTGAGGATGTG CAGATGAGTAAGAATCTATGCAGACAGC

GGGCATTGTGGGCACCTGAATGCCAATG TGGGGGAAGGTGCCCACCAGTTAGTCC

ATGATGGAAGTGGCAAAGCTTGAGTAGC GGAAAACTGACAAACACATGAAAAATTAC

ACAAAGCCAGAAGACCTTCCCAGAGTTG AAAGAAAAMGACCTGGACCTTCCACCA

GAAA I I I I I I AACTTTGAGCCAGCAGCTT AGAAAATTACACTTCCTCACCACCTCAAT

CCCTTAGAACTTGGAGCTCTATTAGTAAA ATGTTCCCCATAAAGGATCTCCGCAAAAT

CATCTAGTTAAATCTTTTCATACTCTAGAT ATCCAAGAACATGTGCCATCTCAGGACC

GAGGAAACTGAGGCCCACAGAAGGGTAA TTCATCAGCTACATTTAAA

AGACCTGCCTGAAGCCCCATACAACTCA

TATCTCCTAGCTCCCTTCCTGGGTGCTTT

TCCTGACACCCT rs 17277775 16 53757981 TGCACAGATAGAGTTTTAATACTGGATTC A/C CCCTTGGCACTGGAGGGAGATCATCCCT SEQ_0678

TGGATGCAACACTGCAGGAGGAAATTGA CAATCAAGAGTCCCAGGCTTTCACTTTTC

GGCCTGCAATTCAGTTCTTCTGCACCAAA CAGATGAACTCTGAAGGGTGACTAGAAA

GGGTTGGTGGTCAG ATTTATTTGGTCCCT rs12597742 16 53759228 GCACTTTGGGAGGCCGAGGTGGGTGGA A/G GCAATGCTATCAGGTAGATGATAAAGCC SEQ_0679

TCACAAGGTCAGGAGATGGAGACCATCC ACAAGGCAAAGAATGTCAACTGTGACCA

TGGCCAACATGGTGAAACCCCGTCTCTA GAAGATGGAAGAGGCAAAGAATGGACTA £

CTAAAAATATAAAAATTAGCTGGGTGTGA CCCCCAAGAGCCTCCAAAGGGAATGTGG o

\

TGACGCATGCCTGTAATCCCAGCTACTC CCCTGCTAACACTGAATTTCGGACTTCTG

CCAGGAGGCTGAGGCACGAGAATCGCTT GCCTCCAGGACTGTGAGAGGATAAGTAT

GAACCCAGGAGGTGAAGGTTGCAGTGA CTGTTGTTTTAAGCCACCCAGTTGGTGGT

GCCAAGATCGCAGCCTGGTGACAGAGTG GAGTTATTACAGCAGCCACAGGAAACTA

AGACTTCATCTAAAAAATAAATAAATAAAT ACAGGAGGTGTGGCCAGACATTCAGCTT

AAATAAATAAATAAATAATCCAGTGCAGG TTACCATCAGAAAACAAAACAATCAGCAG

GGAAGTGGGCTGAACAGAGGCTCCAGA CCTAAGCTGACCCTTAATTAAGCTTAAGG

AAGATATGTCAAAATGCCTGGAACCAAC AGGCTTCTACTGGCTGCCATGGCAGAAG

CTATAAGTGTGGCCTTATTTGGAAAAAGT ATCTTGAAGGCTGCTACTCCAGATATGTT

GTCTTTACAGATGTAATTAAGCTAAGGAT CTGGTTTTGATCTCCTAACATCCATTTTC

ATAGAGATAAAGAGATCCTTCCTGACTAT GCCTTTTCCTGGCATCTGCATTATTTCTT

CTGGGTGGTGCTAATACAGTGCCAAATG TT

TCCTTATAAAAGAAGGACAGAGTGAGATT

TGAGGCAGACCCAAGAGAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1156819 16 53759882 GGCAACAAAGAAATTGATGGAAAAGCTA G/T GTTGATAGGAAGGCTGGAGCAATGACTT SEQ_0680

TAGTGGAAAATTCACTG AGAAAATGGGGTCCAGGGTGCTGAAATT GAATAGTCCTGTCGGCACTGCCCTTGAA TTGTTTTCCACTCAAGATTCTATGTCCTG AGACAGAGAGAGGCCAGTTGACCAACAT TGTGCTACCTTCTTGCTTCTTAGTAGGGG AATACAAAAGGCCTTAATTTACAGACTCA CCCAAAAGAGGAGAGAGAATATTCCAAA AGAAATAATGCAGATGCCAGGAAAAGGC GAAAATGGATGTTAGGAGATCAAAACCA GAACATATCTGGAGTAGCAGCCTTCAAG ATCTTCTGCCATGGCAGCCAGTAGAAGC CTCCTTAAGCTTAATTAAGGGTCAGCTTA GGCTGCTGATTGTTTTGTTTTCTGATGGT AAAAGCTGAATGTCTGGCCACACCTCCT GTTAGTTTCCTGTGGCTGCTGTAATAACT CACCACCAACTGGGTGGCTTAAAACAAC AGATACTTATCCTCTCACAGTCCTGGAG GCCAGAAGTCCGAAATTCAGTGTTAGCA GGGCCACATTCCCTTTGGAGGCTCTTGG GGGTAGTCCATTCTTTGCCTCTTCCATCT TCTGGTCACAGTTGACATTCTTTGCCTT rs11076081 16 53764074 TnTTGCACTATTCTCTCTGTTCAATTTGC C/T CTCTGAATTTATACAGCAGCTCTGTCAGG SEQ_0681

TCTAACTACACTGTTAGCCTTCTTGTTCC AAGGTTCTGTCCCCCATTGCTGACCAGC TCCAACATCTGAAGCTCAAGGCTGCCAC AACTGAGACAGGTGCTCAGCTAGAAAGT AGAGCCTCTGCTCTCCCCTCTACTGGAA GGTAGTGCTGATTTCAGCATGAAAACTC AGCTAATTCACCACACTGATGCATGGCT CTGACCACTCCATGGGCCTCTCACACAC GACTCCTTCCCTTCATTCAGGTCTTAATG ACATGAGCTCAACTGACCCTGCAAGTCA AACACATCGTATCCTCTGAGTGGCCTTTC GGAGTAGGGATCAGCAGGTGACAGAAAC TGACCCATCTAACGATGTCTGATCTGGTC TCCATTTTACAGGTGAGACAACTGAGGC ACTCTCTCACTAAATGCTCTTTCATTTTCT TCTGCATGTTCAAAGACCTTCCTTGAAGG TCATAGTGAAAGTGACTATAAAATTTATC AGTTTGAACTGAGGTCTTCAGCCAATGG TTCTAAGTTAGAAGACTTTTGAGTGTGAA CTCTAGCTCCTCTC AGGGGTTGCTATTGGTAATTATGCCAGG ACAGTGGACATATTCAGGAGACACGTAG GCACTCTACCCACAGAGCCACTTTCTAC ACGTGTGCATTGCCTCTCTCCCACACAG TGTAGTCCCCTGAGAATAGAGGCTGCAC CTGGGTGCCAGGAATGGCACTGGGCAC TTTGAGCATGGAAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12599100 16 53768970 CCATTTAAGACTTCCTGGAACTCCCTGGA CfT TCATTCTTACTATTAACAGTGACTACAGC SEQ_0682

CCAGCAGAACTGCTCTAAGGCTGGAGGC CTGCGTCA I I I I I I CTTCCCACATAGCAG

CTATGTGCACTTCTCTGTCGATGGGCTT TATTTTATAAGATGGCCCAGGACCTGGC

GTTCCCGCATCTCACTATGGCAAGGGTC AATTCAGCCTCCTAAATGCATTACTGATA

CTGGACCAGTCCTCGGAAAAGCTCACCT TATGGTGGTTGTAGTGTCTAGGATAGAG

TTAGGCCAATCACATCTCCTTTTAAGGCC AGAGATATATCTGGGAAGTCAGCAAAGG

CAATGCTGCACAGGGGAAATGCTCTATG AAAGGGCAAAGGAATTAGGGATGGCTTA

TG T rs2589001 16 53776363 CATACTCACTTTTTAAAACAGACAGAAGC C/T CTTTTCTGTGTAGCAAATAAGAATAATTTA SEQ_0683

ATAAAGAGGAAATCTGTACTGCCATCACC GAATAAGAAAAAGAACAAGAACATGGCA

CTGATAACATCTGGGGCATTTCTTCCCG GGTACTACATGAATCCTTCTATATACATT

GGCTGGATAGGATCCCAGATACAGCAGC AAATAAATCAATTGCCACGATGATCCTAT

AGGGGACGGGGAGAAAACCAGCCCCAG GAAGTACACCCTATTATTGTCATTCCTAC

GTGCTCCAGCAGGGTGCTGTCAGTGCCC ATTATAGATGAAGGGACCCAGGCTCAGC

CCATGGTAAGGGGAAAATGAATCTTTTCA GGTGATGTGATGGGCACAGCAAGGAAGT

TG GGCAGGGAGCACAGGGATTTGGATGCT

GGCCCAGCCCTTGGCAAAGCACTTTGCC

CATCATAGGTGCTAAGCACTATTTGAAAG

TTAAATCCCTTCCTCACTAGGAGGAGCT £

GGAGGTAGGACTTTCAGTTTAAGAATAG ∞

CAATTACAGCTCACAACCATTAGGATAGC

TACTGTATAAAAACAAAACAGAAAATAGC

AAGTGTTCGTGAGGATGTGAAGAAACTG

GAACCCTTGTGCATTGTTGGTGAGAATG

TAAAATCAGCTGCTGTGGAAAACATAGAA

TTAGCATATGACCCAG rs2087105 16 5377831 1 TTTTCTTGATCTTGTAAGTTCCCTCTTACC A/G AGACTCTTCTGCATGACCCTTGTCTCTGT SEQ_0684

ACAGGGCCTTTGCACACATTTGTCCTTCC TGCAGTTTAGATTTCTTTGTGTGATTACC

ACCAGGATGTTTCTTTCTTTCCCTGCTTA TGATAAATGCCTGTATCTCCCACTGACAG

TTCTTCAG I I I I I GGCTCAAACATCGTCT TGTTAGCTTCTGCAGGGGAGGAGCTGTG

CCTCAGGGAAGG I I I I I CAGTAGCCTGA TCTGCTTTGCTTCCCAMCCTAAGACAAG

GCAGACAGATCATCCCTTCCAATTTTATG GTGTGAGCCACTGCGCCCGGCCAGGTTT

GGCTCTCTCTGCCAT CAACTTCTTATGGAACACATTAAATGTGT

ACATGCTTATCCTTCTTCCCAACTCTCCT

CCTCTGCAATTGTTAGGGGTTGAGTTATA

TCCCCTCAAAATTCATATGTTGAGGGGGT

TAAGTGCTCTCTTTCACCCTCTGTCTTCA

TGTATACATGGATGATGAATGAATGAATG

AATAGATCTCTTATGAATGAATGAATAAA

TAAGAGCATGGGTAATAAACATAGGAGG

CAATTCTGGATATGGTAGGAAACAAAGC CAGGTCCTGCTGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1486742 16 53779181 TAAGCAGAGGATATTCTGTATGTGTTGCA C/T CCATCTCAAAGTTGATGATCTATGATAAG SEQ_0685

TGGGGGATGGGGTGTGGAGAGGAGGTG TATCTGGTCTTGGATAAGAGGACAGTTTT ACAAACAGTATTAACATTTATTACTGCATT TTAGCCAGGAAAGGTGGGACAAAGACAG TTATTGGATTTCCTTGACTCCATCAATGG AGACCTTGAAGCAAGCTGTGTGAGGAGG TAAGATGCATCATCATTTTATATATTGAGA AAAGAGGAAGGAAGCTCAGGCCTAGGAT AAGTAAAAAGTCATTGCCAAGTAAAGTAC TAACGTGTTCTCCATGAAGTAGACGAACA GTACAATGCTTCTTTAATCATTTAGAATTT GGTTGGCTGTGCAGCTGGGTGGACGGG TCATTTCATACTTAATGAAAATGCTCTTTT GC ATACTTATGTAAAAAGATTTTTATCATAGA TCACTTTGCCCACAAGAAAAGGAAAATGT AAGTGAAATAAATTGGCAAAGGTATTCCT GAACCTTCTTTATATTCAGAGACAAACTT TCTGAACTCAGGGTCATTGGTGTCTGTG TTTTCTTGGCTAAAGCCATGCCCCTAGCT GTTAAGACTATTGTCTGGGATTTTCTTCT AAGCAATGACACCCTCAGGCAAACTTTG CTGCCTATATCATTGGTAACACCAATGAT ATCAGACTTGCTCCTGGGCAACATCAAT CCCAATTTCAACTCTGTTAAAATAI I I I I I TAAAGTG rs2631523 16 53779565 GTACCCCAAACATA I I I I I CCTCCTGATA C/T ACAATGCTTCTTTAATCATTTAGAATTTTC SEQ_0686

TTGGATAGTGAGACTGTCAGCTAAAAGT ATTTCATACTTAATGAAAATGCTCTTTTAT GTCTGGTTGTTCATCCAAGTCAATTCTAG ACTTATGTAAAAAGA I I I I I ATCATAGATC AAG I I I I IATTAAGCTTTAGCCAGTTTCTT ACTTTGCCCACAAGAAAAGGAAAATGTAA AAGACTAAGCAGAGGATATTCTGTATGTG GTGAAATAAATTGGCAAAGGTATTCCTGA TTGCATGGGGGATGGGGTGTGGAGAGG ACCTTCTTTATATTCAGAGACAAACTTTCT AGGTGACAAACAGTATTAACATTTATTAC GAACTCAGGGTCATTGGTGTCTGTGTTTT TGCATTTTATTGGATTTCCTTGACTCCAT CTTGGCTAAAGCCATGCCCCTAGCTGTT CAATGGTAAGATGCATCATCATTTTATAT AAGACTATTGTCTGGGATTTTCTTCTAAG ATTGAGAAAGTAAAAAGTCATTGCCAAGT CAATGACACCCTCAGGCAAACTTTGCTG AAAGTACG CCTATATCATTGGTAACACCAATGATATC AGACTTGCTCCTGGGCAACATCAATCCC AATTTCAACTCTGTTAAAATAI I I I I I I AA AGTGCCCATCTCAAAGTTGATGATCTATG ATAAGTATCTGGTCTTGGATAAGAGGACA G I I I I I I AGCCAGGAAAGGTGGGAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11078674 17 7251197 AGCACCCCCTCTCCCAAGCCAGAGGCCT A/C CCAAACCAAGCCAGCCCCTTCCCGTCTT SEQ_0687

GGTCACTAAGGCTAGGCTTTGATTGGCC CCTCCAGAACCCCCCTCCAGGGTTAAAG

AACAGGCAGGGCTTTTAGCGTTCTTGGT CTGCAGCCCGTTGCCGAGGTAACATTGC

GCCCCCAATCTCCCCCTCCTCTCAACAT GGGGCAGCATCCCGTCACCCGGCAACC

ATATACTTCTTCCTCTATGTTAAGGTTGG GGCTGCAGGATCACGCATCTGTCCCTGG

GGGGAACTCTTGCATTCTGACTCACGCC ATTTGCCCCTCCAGCGTCCCCTCCCTAC

TTTGCCCTCCCCTTCATGCCCTGAATGG TCTAACCCCAGCCTCAAGGTACCCCAAC

ACC TTCTG rs7405696 17 33176148 AAAGCCCCCAAGAACCTTATAAATAATGG C/G GAGAAAGGCACCGGTCCCGAAGAGGGC SEQ_0688

CAAAACCTTTTAAGTCCGACTTAAAAGAG CTGCGGCCATTGTGTCCCAAGCGCAGGT

TGAGGAGTAAGATGGCGCAGTTATACCτ GTCAAACGCCGGCCGCGGCGCCCGCAG

TCACAGCCCTCTGACCCCAAAATTCACG GGTCCGTCCCGCACGCTCCTTCTCAAAC

TGTGTTCACCGGGAAGAGCCGGGAGAG AATGACTTTGCTGCCCACGAGCAGAGAA

CTGGTTATTTTTGTTTGTTTGTTTGAAAAC GCCTGGACTCCAGCGCAGTCCGCAGCG

ACAGCTCAGGTTCAGAGGTTCCCTAACA CGTTCGTTAAGGAGCCCAACTTCGGCTT

C CTTAGAA rs162430 17 39385935 CACCTGGGGGCGTGGCCAGATCTGACC C/T TTAACGACGTCTCCCAGGCTCGCCTCCC SEQ_0689

ACGCTCTTCCCTTCCCCGCCCCCAGGTA CAGATCCAATTCCTTCCCCTTCGCTTCCG

TGGGAAAAGAGACGGCCCGGACACGCT CAGGTCGGAGGGCCCACACCTGTGGTG *■

TCTTTCCAAAACGTTCTTCCCCGACGGC AGGACCCCTGAGGCCTCCTGGGAGATCT O

GAGGACCGCCCCGTCAGGTCGCGGTAA GCCAACCACGCCCACGTCATTTGCATAC

AAGCGCCCGTTACCACACATCCTGCATC GCACTCCCGACCCCAGAAACCCGGATTC

CGAGAGCGCGGCCTGGCCCTACCCTGG TGCCTCCCGACGGCGGCGTCTGGGCAG

CAACATCA GGTTC rs231461 17 39388569 AAATAGCCCCCTACTCTCTGGTATCCTTG C/T TCCTTTGAGACTGGGGTTCTTGAAGGGC SEQ_0690

CCCCCGTTAGCCTGCAGGGTCCTTCTCT AGGGGTGTGTCTTGCCCCCTGGATGAGG

AGGCCCTGATCCCTGGGATCACAGATGT GCTCCCTAAGAAGAATGATTTTTCTCCTC

CCTAACCAGCCCCCACTGCCCCCTCCAT CCTCCAACGGCAGGATCTATGTCCCCTT

CCTAGGGTGAGCACCTGTCTTTTGTCTTT GTCCTGGTGTCCTCTTCCACCCCCATGC

CCATGGAGGAATGGAATTATTTGATTTCT TCAGCAGGGCACCCTGGTGTTTCCTGGG

GCTGTCTCCCCTCCAAACAGGACAAAGG ATGTGGAGTCCCATGGGGCCTGACTGGC

CTGTCTCTGTCTCTCTGTATCTGTTCTGG TGATAAGGAGCCATTTCCGGAGAATGCA

GAACCGCTCATACTGGGGCTCCCCTATG GGTGATTGAACCCATAAAATGGTGACAG

ACATGGCCATATCT AGAGCCCTGAACTCCCCATCTCAGGAGA

GCTCTAAAAATAGCGCCCACAGCCATCT

GTCCTGGGGCTGGAGGGGCTGGCTCAG

AACCAAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9890045 17 39404624 ATTACCCATTCTAATGTGTGGATAGTGCA C/G GGTTCTTTATATATTCTGGATACAAGTCT SEQ_0691

GCTCATCATGGTrTTAACTTGCATTTTCC TTTGCTGAATATGTGATTTGCAACTATTTT GGCCAAGCGTGGTGGCTCACACCTGTAA CTTTCAGTCCGTAGCTGG I I I I I I CGTTT TCCCAGCACTTTGGGAGGCCAAGGTGG TCTTAACCCTGTCTTTCATAGAACAAAAG GCAGATCACGTGAGATCCTGAGTTCAAG I I I I IATTTATGATGMGTCCAATTTATCA ACCAGCCTGGCCAGTATGGTGAAACCCC ATTGTTCTCTTTTGTGACTCATTCTTTTGG ATCTCTACTAAAAATATAAAAATTGGCCG GTGTCCAGTCTAAGAACTATTTGCCTAAA GGCATGGTGACACAAGTCTGTAATCCCA CTGAGGTCATGAAGATTTTCCCCTACTTT GCTACTCAGTAGGCTGAGGCAAGAGAAT TCTCTAMGTTTTATTATTTTACATTGCTT CACTTGAACCTGGGAGGTGTAGGTTGCA TCCCTTTTGAGCTM I I I I I GTATMGGT GTGAGCCAAGATCATGCCACCACACTCC ATGAGGTTTCGGTTGAAATTCTC I I I I I I AGCCTGGGTGACAGAGCAAGGCTCTGTC GTGTATGAATGTTTATTGTTCAGACACCA TCAAAAAAAAAAAAAAAAATTGCATCTTTC TTATTGGGTCTAGGMTCTATACATGTGT TGTTGTCTAATGATGTCAAACATCTATTC TAMGCTCATAMGCTGTACACCAACAAA ATGTGCTTATCTGCCATCTTTATATCCTC ATGGTCMTTTTATTTTATGTTACTTTAGT CTTGGTGCAGTGTCTGTTCATGTGGTTTT TATTTATTTATTTTATTTTATTTTATTTATTT I I I I I I I I IAAGTGGGTTGTTGGTTTTCTT ATTTATTTATTTATTTATTTATTTATTG ATTGTTGAGTTTGAA rs9907468 17 39407615 GATTCAGACCGTCCTGCACAAACTGCCC CfT GGGMTTCGGGTCCTMCATTGTATTCTA SEQ_0692

CCTTTACTAGTAGAGGGTGGGGTGGAAG AAAATGTTCAGAGTTACAGCAMTTGAAA GGCAGGCAGTGGGGGATGGTTCTAGGT MGGCTGTTCAGCMGTGGTGCTGGTGA GAACACGCAGGCACCTTTGGAGGGAGG GGATTAGGATGC I I I I I CTTTCTTTTGGC TGTCCCATGGTTGCTCAAAGCCCCACTC TTAGCTATAGTTTATA I l I I I CTACAGCAG CAGAATCCGACAAAACCTGCTTCAAACC ACATATATTATTTCGATAATTAGAAATAAA CTGTGTCAATTGTTCACCCAGTCTCTGTG TATGGGGGGGAGGATAGGGAAAAAAAAG GTGTGAGCAAATCATTTCATCTCTGAGCT TTCMCAGAGTAGGACAAAGGACAGAGC TTGGTTTTGTCATCTGTGAAAAATAGGTC CCTGTGGTGCAMGCCGCCATCTCCCGC ATAAAAGTGCCCGTAAAGGGTTAGGAGG TTTCAGTCATGGATTGCCTTTAGMGCAG ATTGAATGAAATAATGGCTGTCAGAAGCT CCTCTCATTTAATTAGAAATTCTTCCAGC CAGGACTGTTGCCAGCTCAATGTAAGCA CGTTGAGCCATTTCGCCCACACATCACC CCCCATAACGTGCTACATTTTCTTGCTAT CCATGTCTGCAGGATGTCAGGAGAGATT TGTTTGCAATAAAGAGACTGGCAGGATG GTGCTGTGTGCCTTGCTGAAGTCCAGAC CGCCCTCAGTGTGAACAGTGGAGTTATC ATGAGGAGTTGCGGCACTCCTATCCCCG TTTTGTTG ACCAAATAATTCCATCAACGGGGAAAATC AGATCAACCCAGAACCATCTGTTCTTAAT GGTTTCTGMCAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 12603224 17 39408261 ACATATATTATTTCGATAATTAGAAATAAA CiT AAAAAGAGAATAGTAAAGCTCGTGTCACA SEQ_0693

TATGGGGGGGAGGATAGGGAAAAAAAAG GGCTTCTTTTGGCAATTAAACAGTGGGTA

TTCAACAGAGTAGGACAAAGGACAGAGC GGCTGAGCACAGTGGCTCTTACCTGTAA

CCTGTGGTGCAAAGCCGCCATCTCCCGC TCCTAGCACTTTGAGAGGCCAAGTTGGG

TTTCAGTCATGGATTGCCTTTAGAAGCAG CGGATTGCTTGAGCCCAGGAGTTCAAGA

CCTCTCATTTAATTAGAAATTCTTCCAGC GCAGCCTGGGCAACATAGCGAAATCTTG

CGTTGAGCCATTTCGCCCACACATCACC TCCTACTAAAAATAAAAATAAAATAAAATA

CCATGTCTGCAGGATGTCAGGAGAGATT AAATAGCTGAGTATTGTAGCACGTGCCT

GTGCTGTGTGCCTTGCTGAAGTCCAGAC GTTGTCCCAGCTACTTAGGAGGCTGAGG

ATGAGGAGTTGCGGCACTCCTATCCCCG CGGGACAATCACCTGAGCCCAGAAAGTC

ACCAAATAATTCCATCAACGGGGAAAATC AAGGCTGCAGTGAGCCGAGATCATACCA

AGATCAACCCAGAACCATCTGTTCTTAAT CTGCACTCCAGCCTGGGTGACAGGAGTA

GGTTTCTGAACATGTCTTTCCTTTCCACA AGACCCTGAAAAAAAAAAATATATATATA

TACTTACAAACCTAGGGGTGGTGGAAAG TATATATATACACACACACACACATATATA

GGTATGGATTCCGGAGTCAGATGTTCTG TATACACACATATATACACGTGTACATAC

GGTTTGAATCCCACTCGCATTTCTTAGCT ACGTGTCTACGTACGTGTACATACACGT

GTGTGACTTTGAGAGAGTTTGCTTGGCC GTCTACGTACGTGTACATACACGTGTCTA

TCTCTGAGCCTCACTG CGTACGTGTACATAC rs8070257 17 45796996 CCCAGCCAAGACTTGAGAAGTATGCTGC A/G TGTCTCTGTAAAATCTCCCTTACACACAT SEQ_0694 K* ACATGGCTGGTCTTTGATCCCTCTGGTC CACCCCCTGGGCTGCAGGCAGGGAAGG CCTTCCCTGTGCCAGGTCCTATGATGCC GACAGGGCTACTCTGCTCCCCCTCACAA ACAATCTTTGGTAACAAGAGGGGCTGGG ATCTCTGCCCCAGGGACTTGATGCCGTA CACCAGGAGCTGTTGAGCTGGGCTCTTG GCAAAAAGGGAGCTGCCTGCACCTCAGT GGTCCTTTCCTGCCTCCTCAGATCCAGTT TTGCCTTGCTTGTCAAGCTGGTATCAGTA TCTCAGGGTATCTGCTCCATCCCCTCCC CCAGCCAGGTCATTCCTACACCAGCTTC TGG rs 16948935 17 45798284 AGGTCCAGCCAGTGGAAAGGAGCCGAG G/T GAAGCCAGGCAAGGGACCTAGCGTGGT SEQ_0695 AGTCCCAAGGGATACAAGTGAGGCTCCC TAAGGGGACTAAAAAGAACGCAGGGGAG TGGGCCTGCCACCTGGGATGGGGGAAA GGGAAGGATGGGATGAAGACTGGAGAG AAGTGTGTGCTGGGGTTC GCTTCTTGGAGGAGAGGG rs 16948937 17 45799938 CAAGCTCTCTCTCTGCCCTAGACCTGGA A/G AGAACATGACTGTGTTGCTTCCTTTACTG SEQ_0696 CAGGCAGGGAAGAGGGTTTCCTGTGGC GCTGCTCCCACCCCTCCTCCCAGGGCCC CACCTCTGGGGCTGCAGCCCCAGCTCC AGCCCTTGGCC I I I I I I GGGATCTAAGA CTTGGCATGTGGCTACAG GGAGAAGCAGCAATG rs 17776853 17 45801129 AGTTTGATGTAAATTTTCATTTAGATAGTG A/G ATCATACTACTGCATTAGCTAATACCCAT SEQ_0697 ATCTATAAAGTTTAGGCTCTATGGAAAAT GTAAGCCCTTTAATACACATTAAGTCATT ATAAACCAAAGCTATATGGATAATGCATA TAATTCTCACCTAGTGAAAGAGGTATTAT TGCTAATAAAAC TTCCAACGCCACT rs 16948951 17 45803022 GGAGTGGGGCTTAGCAAGGATGTAACTG C/G GTGAGAGGCGGTGGGGAGATGAGAAAG SEQ_0698 CAGAGAAAACAGAAACATTGTTCAGACA CTGTGTCAGGGGAGCAGAAGTGCCACTG GACAGGCTCAAACTATTTCTGCCTCAATG AGTGTATTAGTTCTCAGGGAATACCTCTA GGCCACATGCTGATA AGTCCTTGGCTTTCTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 16948981 17 45812250 CTGCAGGCTGATATCATAGGCCAGGTTA A/G GCCTACTCAGTTCAAGAAGTGTTCACTGT SEQ_0699 CCATAGGCCAAGTTACCAGGATTAATTAC CAGAATTTAAAATAAGTAAATGACCTCAG AGGTCAGATCACAATGTAATAAGCACTAG AGACAATCCAGTCCAAGTCCCTTATTTTA GAAAGCAAA I M I I TACTTGAGGGGAC rs917029 17 45812566 TGTCTCCTCCAGACTAGTGCGAGTCCCC C/T GCCATGTTACATCTGGCC I I I I I GTGCCT SEQ_0700 TGCCAGCAAGGTCCACCTTCACCCCTCC TTGACAATTTGAGTGCTCACTTTGTTGCC AGCCCAGTCACTCTCCAGACAGAAGGAG AGGTATAGGGCCAGTTGCTGATTCATTTA AAGGTAGTTTCATCTCGGAGCTTCCTGC AAAACTACATCTAGTCCATTATAGTAGAA AACAGCGTGGTTGGAGAGCTGTAAGTTG GAAAAGATACCAGATTCTTTGGATATCTG CTCATTACTCTTCTACACCTGTTCCCCTC GCAATCTGCAATCTATTTCTGGTTCTTCT AAGTGGCAACTGAAAACCCCCCCACTGA AACTGCTAGGAGCTTAGACAAGTCAATCT CCTTGGAAGAGGTGGG CTTCAGGCCTCAGTCCCCTCAAGTATAAA ATAAGGGACTTGGACTGGATTGTCTCTG AGGTCATTTACTTATTTTAAATTCTGACAG TGAACACTTCTTGAACTGAGTAGGCCAAA AATTTGCTTTCCTAGTGCTTATTACATTGT GATCTGACCTGTAATTAATCCTGGTAACT TGGCCTATGGTAACCTGGC rs917028 17 45812608 CTGCTGAATCTGTCTCCTCCAGACTAGT C/G TGGCAACTGAAAACCCCCCCACTGACCT SEQ_0701

GCGAGTCCCCTGCCAGCAAGGTCCACCT TGGAAGAGGTGGGCGCCATGTTACATCT

TCACCCCTCCAGCCCAGTCACTCTCCAG GGCC I I I I I GTGCCTTTGACAATTTGAGT

ACAGAAGGAGAAGGTAGTTTCATCTCGG GCTCACTTTGTTGCCAGGTATAGGGCCA

AGCTTCCTGCAACAGCGTGGTTGGAGAG GTTGCTGATTCATTTAAAAACTACATCTA

CTGTAAGTTGCTCATTACTCTTCTACACC GTCCATTATAGTAGAAGAAAAGATACCAG

TGTTCCCCTCAA ATTCTTTGGATATCTGGCAATCTGCAATC TATTTCTGGTTCTTCTAACTGCTAGGAGC TTAGACAAGTCAATCTCTTCAGGCCTCAG TCCCCTCAAGTATAAAATAAGGGACTTGG ACTGGATTGTCTCTGAGGTCATTTACTTA TTTTAAATTCTGACAGTGAACACTTCTTG AACTGAGTAGGCCAAAAATTTGCTTTCCT AGTGCTTATTACATTGTGATCTGACCTGT AATTAATCCTGGTAACTTGGCCTATGGTA ACCTGGCCTATGATATCAGCCTGCAGAA CACAT rs 12902 17 45814180 AAGTAGCATCATGGAGCTGAAAAGTGGT A/G ACAAGGATCACACTGTCCATTCTCTTGTC SEQ_0702

GCATCACCCAATGGCTAGCACA TGCTAAATTAAGCATTTTCTT rs10491145 17 45817955 GAAGATAGGAGTCCCATAGAAAACTGCC C/G TAGAGGAGCACCACTTATCCCTCATGCC SEQ_0703

ATGG I I I I I I CTCTTCATAGCTGAGTTCT TTTCTTAGGTCCTCCTTGTTATΠTACCCT

AGAAGGCAATCAGTTGCTATGCCTTCTG AATTTCTCTGCTGCTTGAGGATAGGAACC

AGTTAGTACCTAATT TCGTAATCAGAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12452992 17 45820089 AGCAGAGATGTGGGATTATGAAGCCAGC CfT AGGGAAAGTGATTTCCTATTACAGGGAA SEQ_0704

ACTTAAAGAGACTAAGGGAAAAGGAAAC CACTGGGAGGGACTGAAGGGCCATCAG

CCAGCAAAGCCCCTGAGTGAGACTGCAG GAATCTGTTTTAGCCACATTTCATATGAA

TTGGTGTACTCAAGCTGAAGTTAATGGC TGCCTATTAACCCTCCAAGCAGAGATGA

CCAGTTTCACTTGTGTGTGCAACAAGGC AATATAAGCAGTTGACTGCCTCTAGAGCA

CGGTGGAGAGCAGGCAAGTAAGCTTGG CAGCAGAGAAGCCAGGACTGAAGAGAG

GCCAAGGTGGGTTTTGCTGGCCTTGTCA ATTCATCAGATAAAGACGATACCATCCAC

ATGAGTTTGGATTTCATTCTAAGTTCAGT CACAATACTGTCCCCCCACCGCCCACTA

GGGATGCCATTAGAGGGTTTTAAGCAAG ACTGTTCTTCATGACTACTCTACTGGATC

TAGCAGCATAATTATTTATGTTGTAAAAA CCAGCTCCTGAAGCATGAGAATCCACTG

GATCTCCCAGACTGTTGTGAAGAGAATG GCTGGGATGAGGACCTGAAAGATAACTA

AGTTTAAGGAGATGGCAGCATCATGGAG CAAGAGGGACAGCCACCTACCACGTTCT

ACATGCTGGAAGGCATTGTGATGGTCCC ACTTCCAGCCGCCGCTGCCTCTCCCGCT

AGAATGGTGGCTGGTTAGAGATGGCACC CCTGATCTGCCTGCACGGCCTTC

GGAGCTGGAGAAACAGTCCCACATAGGA

CTTGCTGACAGATTGGATGTGGGAATTA

CAGAAAAAAAGGAGTCATTAACATCTTTC

CTATTTTAGGCTTGAATAACTA rs757509 17 45824723 AGGGACTATGTATGTGAACTCGGGCTTA A/G CACTCCCTGGGATTTCTCCTCCTCCTGTT SEQ_0705 4-.

ATGAGCCTCTTTGCCCATCGCCCATCTCT TTTCCCTCCTAGGGCACCTGGAGCTTTG

TTAGAACCTGAAGTGGTTGGACCTGAAG TGTGGAGTTAAGCATTCAGGTCCGAGTG

GATAACCCCCTGGATCCTGTCCTGGCCA AAATATGTCCACTATGAGCCTGTCAAACA

AGGTGGCAGGTGACTGCTTGGATGAGAA GAGACCTTTGTTTCTGCATTTACTTTATCT

GCAGTGTAAGCAGTGTGCAAACAAGGTA TTTTG I I I I I IATTTGTTTTGAGACAGAGT

AGCACCAAGCTCCCTCCCAGTGGCTCCT TGCTCTGTTGCCCAGGTTGGAGTGCAAG

TAT TGGCACAATCTCGGCCCACTCCAACCTC

CGCCTCCCAGGTTCAAGCGATTCTCCTG CCTCAGCCTCCCGAGTAGCTGAGATTAC AGACGCCTGCTACCATGCTCAGCTAATTT TTGTA I I I I I I AGTGGAGATGGTGTTTCG CCACGTTGGCCAGGCTGGTCTCCAACTC

CCGACCTCAAATGATTCGCCCACCTTGG

CCTTCCAAAGTGCTGGGATTATAGGCGT

GAGCCACCATGCCTGGCCTGCACTTAGT

TCGCAAGTCGCAGAACAAGACTGCCTTC

TCTACTGCAGTACTTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4794139 17 45830075 CGGTGCCGCGACGACGACCACTTCCGT A/G AAAGGGCACGGACTGGGCGCCAGAAGA SEQ_0706

GTCCACGTCACCTTCCGCGACCACTGAG CTGGGTTGACATCCAATACTGACCTCATC

ATGGGCTGGGCCAGAGCGGCCCGAGCG AGATCACCCCAATCCCCCTGATTAGGAG

TGTGCGGGCACGCCCCCTGGTGCCCAG CAGAAGCTGGGTGTCCTCTAAAACTGCT

GGTGATGCACTGCACGTCGCCGCCGCC CCCTGTCCTCTACTTAACCCCCGAATAAC

GGAGGGGTGGGGTTGGAGGCTGCGAGC CATCATGGGGAAAACTCTTCTTCCTGAAT

TCGGTTCACGTTCACCCGTGGCCCGCGG TTCTCCTCTCTCCTCCCCACTCACTGCCT

GCATTATTGCTGGCAGTGCCACGAGGC CAGTGCTTGTCTCTGTCCTTCCATCCACT

TTCACC rs1015562 17 45838282 TCACTTTCCTGCTGTGATTGTCATTAAAT C/T TAAGAGAGGGAGTACGATGAAATGTGCC SEQ_0707

AGTTGACC I I I I I GAACCTCAATCACTTC TCACTGTCTCCTCATGTACATTATCAAAA

ACCTGTAAAACTGAAATAATGTCTGCCTT TAAGATAATGGATGCTCAAGGATTTAGAG

ATAAGTCTGTTGTGAAGGCCGAGTTAAAA ATTGCCAAATGCTAATGTATGTATTATCC

GACATAATATATGTAAAGCACAGTCTGAG AATTGCCCTTGTCTGTTTCCCAGAAGCCC

GCACAAATAATG I I I I I GCACCTGTCAAC AGCACAGTGCCTTGCTGGCGACGGGTTG

CTGATGTTATCACACACACACAGCACTAC GGGTGTGCACAGCGGGGATTTGATAAAT

ATATTCATGCACAGATCTCATCTCTATGT AAGGAGTAGGCCATTGTGAGAGAGAGGC

GTTCAGGCACTTATCCTTTTACCTTTTATA AGGACTAGCTGGATTTCCTAGGCCGACT

ATAATTATTTGCATGGACTGTAGGCTCCT AAGAATCCCTAAGCCTAACTGGGAAGGT 4-.

TCATGGTAGGAAAAATAGGGTGTAGTGA GACCGCATCCACCTTTAAACATGGGGCT $

AAAGAAACAGGATTTGGAATAAAAAAGTC TGCAACTTAGCTCACACCCAACCAATCA

TGCCCCTCAACCAAAGGTGTGGCTGAGA GGTAGTAAAGAGAGCTCAGTAAAATGCT

ACAAGTGACTTTTCCTCTCTGAGCTTTGG AAGTAGGCAAAAACAGGAGGTAAAGTAA

TTTCTTCCTCC TAGCCAATAATCTATCACCTGAGAGCACA

GGAGGAGGGACAATGATCGGGATATAAA CCCAGGCATTCAAGCTGGCAACAGTAAC CCCCTTTGGGTCCCCTTCCATTTTATGGG AGCTCTGTTTTCACTCTATTAAATCTTGC AACTGCACAATGTTCTGGTCCATGTTTGT TACAGCTTGAGCTGAGCTTTCACTTGCTG TCCACCACTGCTGTTTGCCACTGTCACA GACCTGCTGCTGACTTCCACCCCTCCAG

ATCCGGCAGAGTGTCCGCTGTGCTCCTG

ATCCAGCAAGGTGCCCACTGCCGCTCCC

GATTGGGCTAAAGGCTTGCTATTGTTCCT

CCACGGCTAAGTGCCCAGGTTCATCCTA

ATCGAGCTGAAGAGAGCTATAACACTCA

CTGCATGGCCCAAGATTCCATTCCTTGG

A

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4793654 17 45839197 TCTGTTGGCAGCC H I M CTTGGAAACAA GfT CAACTTGTTACACTCCCAGCTTCTGTTCC SEQ_0708 CAGGCTGGCCCTATGCTGAACCCCCCAA TCCTTCTGTAAAACGGGTATAATAGCCAG AACCAAATGCCACTTTGTGCTTGGATGTC GTGCAGCAGCCATTGCCTGTAATCCCAG TGAGGTTGTTAGGGGAGCTGCCAAACAG CTACTTGGGAGGCGGAGGCAGGAGGAT AACACAAGTACCAGCAGCAATTGAGAAG CGCCTGAGCCTAGGAGTTTGAGGCCAAT CCCAAGATCAAGACTAGGACAGGAGTCA CTAGGCAACATAGTGAGAGCACCCCCCT TCAGCTGCCTGAAAACCCTTGGGCGTCA ATTCTAAATAAATAAA I I I I I AAACATTGA GGCCAGTGCAGCCACTGCTAACTCTGGG AAAAGTGAGCATAATAATATGAAGTAGCA GCAATCTTG CATCAAGGATCCACAGAGAGACAGGAGA

GAAAGAGCCAATAGCACCACGCAGCAGG

AATCAACCTΠTTAAGGGCAGCTGAGTCC

CTTTGGCAGGTGGGTTGAAAAAAAAAAA

AGGCAGGCCAGGCATGGTGGCTCGTGT

CTGTAATCCCAGCACTTTGAGAGGACAA

GGCGAGTGATCACCTGAGGCCAGGAGTT

CAAGATCAGCCTGGCCAACGTGGTGAAA

CTCCATCTCTACTTTAAAAAATACAAAAAT

TAGCTAGGTGTGGTGGCA rs12451568 17 45839885 TTTAAACATTGAAAAAGTGAGCATAATAA A/C CCCAAAGTATATTTTAATATTGATCTCCAT SEQ_0709 TATGAAGTAGCACATCAAGGATCCACAG TTATATAGTTTACTTACTTACATAAATTTG AGAGACAGGAGAGAAAGAGCCAATAGCA C I I I I I I CGAGACAGAGTCTCTGTCTCCC CCACGCAGCAGGAATCAACCTTTTTAAG AGGCTGGAATGCAGTGGCATGATCTCAG GGCAGCTGAGTCCCTTTGGCAGGTGGGT CTCACTGCAGCCTCCACCTCCTGGGTTC TGAAAAAAAAAAAAGGCAGGCCAGGCAT AAGCGATTCTCCTGCTTCAGCCTCCAAG GGTGGCTCGTGTCTGTAATCCCAGCACT TAGCTGGGATTACAGGTGCGCGCCACCA TTGAGAGGACAAGGCGAGTGATCACCTG TGCCCAGCTAATTTTTGTA I I I I I AGTAG AGGCCAGGAGTTCAAGATCAGCCTGGCC ATACGGGGTTTTGCCATGTTGACCAGGC AACGTGGTGAAACTCCATCTCTACTTTAA TTCTCTTGAACTCCTGGCCTCAGGTGATT AAAATACAAAAATTAGCTAGGTGTGGTGG CGCCCACCTCAGCCTTCCAAAGTGCTGG CATGTGCCTGTAGTCTCAGCTACTCTACT GATTACAGACATAAGCCACCACGCTTGG CGGGAGGCTGAGGCAGAAGAATTGCTTG CTATAAATTCGCCTTAAATACTTCCACAT AACCCAGGAGGTGGATGCTGCAGCGAG GTAGAGACATACATGTGGAATGTAAGTC CCAAGATCACACCACCACACTCCATCCA ACCATGTTCCTGTAAGTCAGCCTTTCCCA GCCTGGGCAACAGAGCTAGACTCCATCT AGGTAACCCTCAAATTGAAGGCAACTGC CAAGTTAAAAAAAAAAAAAAAAGCAGTCT AATTAGAAATCCCAAGATTTTTGTTTC CAGGCCTTGAGGATGTGAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs9889347 17 45840648 CTTGAACTCCTGGCCTCAGGTGATTCGC C/G ACCACCTAGCAAAAGTGCTGGGATTATA SEQ_0710

CCACCTCAGCCTTCCAAAGTGCTGGGAT GGCAGGCCACTGCGCCTGGCCTAATATT TACAGACATAAGCCACCACGCTTGGCTA ATCTTAAAATGCATATAGAGGGGCTGGAT TAAATTCGCCTTAAATACTTCCACATGTA GCAGTGGCTCATGCCTGTAATCCCAGCA GAGACATACATGTGGAATGTAAGTCACC CTTTGGGAGGCTGAGGTGGGAAGATCAC ATGTTCCTGTAAGTCAGCCTTTCCCAAGG GAGATCAAGAGATGGAGATCATCCTGGC

TAACCCTCAAATTGAAGGCAACTGCAATT CAACATGGTGAAACCCTGTCTCTACTAAA

AGAAATCCCAAGAI I I I IGTTTCA I I I I I G AATACAAAAATTAGCTGGGCATGGTGGC

TΠTTAGAACTAAGTAAATATTCTCTTTTT ACGCGCCTGTAGTCCCAGCTACTCGGGA

TTGTTTGTTTGAGACAGGGTCTTGCTCTG GGCTGAGGCAGGAGAATCATTTGAACCC

TTGCCTAGCTGGAATGCAGTGGTACGAT AGGAGGCAGAGGTTGCAGTGAGCCGAG

CACAGCTCACTGGAGTCTCCACCTCCCA ATTGCGCCACTGCACTCCAGCCTGGGCA

GTGCTCAAGTGATCCTCTCCACCTTAGC ACAGAGTGAGACTCCATCTCAAAAAAAAA

CTCCCTAGTAGCTGGGACCACAGGCATG AAAAAAAAAAAAGCATACAGAGGGGGCC

GACCACTGTACTCGGCTA I I I I I IAATTT AGGTGCGGTGGCTCATGCCCGTAATCCC

I I I I I GGAGACGGGGTCTCCCTATGTTG AGCACTTTGGAAGTCCGAGGCGGGTGG

CCCAGGCTGGTCTTGAACTCCTGGGCTC CACCAGGTCAGGAGTCCAAGACCAGCCT

AAGAGATCCTTTCAC GGCCAAGATGGTGAAACCCCATC

Ui

RS 16949053 17 45844439 TTCTCCCCTCTGTTCATTCCATTTGGAAT C/T TCTAAGAAGTCTTACCTGATCACCCTGAC SEQ 0711

GTCCTCTCCTTCCTCCCTTTCCATGGTCA CAAAAGTGAGCCATTCTTCTGATGCCCAT CCATCCTTTTCATCCTTCAAAGTCCAGTC AGCACTATGTCCCGCTTTGCATTAGTTGT CAAATACCACCTC TGGCATGGGTAGC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs7211667 17 45844603 CTTGTTTGTTGGTTGGTTTTGAGACAGGG C/T ATCAAAGGCATGCCAAGACCATGAGGGA SEQ_0712

ACTTGGTCTGTTGCCCAGGCTAAAGTGC AGGCACTACCTACTTCAAAAAAATAAAAC

AGTGGTGGCGTGATCAGGTGACTGTAAC AAGGAAGACAGAGGGAGATCCGACAGA

I I I I I I I C I I I I I I I I I I I I I AAATAGAGAC GAAGAGGAGGAAATGTGAGCACAGATGC

GGAGTTTCATCATGGTGCCCCTGCTGGT AGAGATTGGAGTGATGTGGCAACAAGCC

CTTGAACTCTTGGGCTCAAGTGATCTGC AAAGAACAACTGGAGTCACTAGGTGCTG

CCGTCTCAGTCTCCCAAAGTGCTGGGAT TAAGAGACAAAGAATGGATTCTTCTCTGG

TATAGGCCTGAGCCATGGCACCCAGCCA TTCCCCTCTAAGGAACTAGCCCTGCCAA

GCTCACTGTAACTTCAAACGCCTTTGTTC CACCTTGATTTTATTTATTTATTTAATTTTG

AAGGTTTCTCCCACTTCAGCCTCCTGAGT TTTAAGACAGAGTCTCACTTTATTGCCCA

AGCTGGGACTACAGGCGTGCACCACCAC GGCTGGAGTGCAGTGGTGTGACTGATCT

GCCCAGCTAGAAGCTAI I I I I I CATAAGG CTGCCCACTGCAACCTCTGCCTCCCGGC

ATTAAATGAGTTCTTAGTCCATAGAAGGC TTCAAGCGATTCTTGTACCTTAGCTTCCC

ACTCAAAAAAATCATTCCTGTAAAACCGT GAGGAGCTGAGATTACAGGTGTGTGCCA

TCATCTCTTCCTTATTCCTGCCTTCTCCC CCATGCCCAGCTAA I I I I IATA I I I I IAAT

CTCTGTTCATTCCATTTGGAATGTCCTCT AGAGATGGAGCATTGCTGTAGCAGGACA

CCTTCCTCCCTTTCCATGGTCACCATCCT AGCCACAAACAAAACCCCTCAGACACTG

TTTCATCCTTCAAAGTCCAGTCCAAATAC AGTTAAAGAAGGAAGGGCTTTATTCGGC

CACCTCCTCTAAGAAGTCTTACCTGATCA CAGGAGCTTCAGCAAGAGTCATGTCTCC 8;

CCCTGACCAAAAGTGAGCCATTCTTCTG AATGACCGAGCTCTCCAAGTGAGCAATT ∞

ATGCCCATAGCACTATGTCCCGCTTTGC CCTGTCCCTTTTAAGGGCTCACAACTCTA

ATTAGTTGTTGGCATGGGTAGCAGTGAT AGTGGGTCCACATGAGAGGGTCGTGATT

AGCAGAGGAGCTCAAGAGGAGTCTGCTG GATTGAGCAAGCAGGGGGTATGTGACTG

GGGGTTTCCAGAGAAAGGCTTTCCTTGC GGTGCTGCATGCACTGGTAATTAGAACA

T GAACAGAACAGGACAGGGATTTTCACAG

TGCTTTTCTATATAATGTCTGTAATCTATA

GATAACATAACCAATTAAGTCAGGGGTCA

ATCTTTAACTACCAGGCCCAGGGTGTGG

TGCCGGGCTGTCTGCCTGTGGATTTCAT

TTCTGCCTTTTAG I I I I rACTTCTTCTTTC

TTTGGAGGCAGAAATTGGGCATAAGACA

ATATGAGGGGTGGTCTCCTCCCTTATTC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11655508 17 45846292 AAATCCATGCCACACTTGCACAGGCACA C/T CTGCCCACTGGTCGGGTAATTTGGTATA SEQ_0713

TGTGCCAGTTTTGTCATATTTCTAACTAT AGCTCTATGCCCACATATCCAGTATAGTC

GTCTTCAACTACTTGCCCTTGATCATCTA CAGTGGGGGCTGTCCAGTCCCAGTGGG

TGTGTAGGCAGCAATTAGTAGGGTTAAAT ACTCCGGGTGGGTTCACACAGTTTGCAA

TTCCTACAGACCCCTCCTTCAGCTGCTA CTTCGGGAATTTACTAAATGGA I I I I I CT

GCAAGTAGTCGAGAGCTAATCTATTTTGA TAGTGTGGTTTGAACTCCACTAGGTGGC

TAGATAGCATTTCTCATCTGAGTTTCTTG TG I I I I I GTAGTATTATTATACAG I I I I TG

CCAGGCCAGAATAGTCAAGGCCCTGCCA CCCAAGGCAGCAGAGTCTTCCCACAGGA

GTCTTATTAGTGATTATTTCTAAGACAACT AGGGTGAAGTCCTTCCTTACTCTTGCTAT

TGTAACTGTGTGATTCGGTTGAGCACGT ACAGTATTGTCTAATGATTGAGGCTTTTA

AAATGGGAGTCGGGTATCCCCACGAGCT GGACCTAGAAGTTATCAGGGTGATTATTT

GTCTTGTGCCTAAGTACCAGGCCTATAAT TGAGCCAGGAATTCATCAGGAACTGGGT

ATTGTATGATTCTCTCAGGGGGCCATTTA CTGTAGGTACTAATTCTCAGGCTTCCTAT

TCATC I I I I I AATTTTCTAGTTATGCTTCT GGCCATTGATCTCCCATTACAGTTCCTCT

ATTTTTGCGGGAAGCACAGACAGGGAAG ACATATCTACATACATAACATGAAGTGAC

CCCAGGAGTTCGCCTGTCTTTATGGGCA ATTGAGAGACTGGGCTAAATGCTCAGCT

GTAGGAAGAAAGATGGTTTAATAGTGCC AATTGCAAAAACAAATTTCTTGTTTTTCCT

AGGAACACAACTA GGAATTTCTGGTA

'Jl

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6504653 17 45847135 CCTTATTCCTGCCTTCTCCCCTCTGTTCA C/T CTCTTCCTTAATTAAGAGAATCACATCCT SEQJD714

TTCCATTTGGAATGTCCTCTCCTTCCTCC ATTTCTAACTTATTACTATTAATGACAGCG CTTTCCATGGTCACCATCCTTTTCATCCT CAGGCATCAAACTTTAAGGTGACTTGTTT TCAAAGTCCAGTCCAAATACCACCTCCTC GGGCACCCC I I I I I CTTTTGTTTTGGCTG TAAGAAGTCTTACCTGATCACCCTGACCA ACACCTTACTCGTATCATTTATGAGCCTT AAAGTGAGCCATTCTTCTGATGCCCATAG CACCAGTCCTCAGTCCTTAATCTTATTTC CACTATGTCCCGCTTTGCATTAGTTGTTG AAAAACTGTGGTCATGGGAGGCTCAGAT GCATGGGTAGCAGTGATAGCAGAGGAG GGGTCATAACACACACGAGGTTGCTCAT CTCAAGAGGAGTCTGCTGGGGGTTTCCA TTCCTGGGCTACATACCTTGCATAGAATA GAGAAAGGCTTTCCTTGCTCATCAAAGG GCATTATACAAACATAGCATTATACAAAC CATGCCAAGACCATGAGGGAAGGCACTA AAG I I I I I I I l I I AGAGTCCCAGTACACTT CCTACTTCAAAAAAATAAAACAAGGAAGA ATAATAATCATAAAATAATAAGACTATAGC

CAGAGGGAGATCCGACAGAGAAGAGGA AAC I I I I I GTCCTACCTCAGTGACTTGAT

GGAAATGTGAGCACAGATGCAGAGATTG GTATGCACTGGGAGCAGTCCCCAGTCTG

GAGTGATGTGGCAACMGCCAAAGAACA AGGAAGGTCAGTTAAAGTCCTTACTGTAC

ACTGGAGTCACTAGGTGCTGTAAGAGAC AAGTCCAAATTTTAAGGCAAATGAGTCCC

AAAGAATGGATTCTTCTCTGGTTCCCCTC ATGATGAGTTTTCTCATGCTTCAGCTGTA

TAAGGAACTAGCCCTGCCAACACCTTGA TGTGGACCAGTCAGCTTCCGGGTGTGAG

TTTTATTTATTTATTTAATTTTGTTTAAGAC TGGAGCAGGGCTTGTCGTCTTCTTCAGA

AGAGTCTCACTTTATTGCCCAGGCTGGA GTCACTTTGCAGAGGTTGGCGAAGCTGC O

GTGCAGTGGTGTGACTGATCTCTGCCCA TCCCGTCTACGTACCGCTCACAGTCTAC

CTGCAACCTCTGCCTCCCGGCTTCAAGC TGATGTTCAAGGATGGTTTTGGAGGTTG

GATTCTTGTACCTTAGCTTCCCGAGGAG GGCCTGGTAGAATAAACTGAGTCCAACA

CTGAGATTACAGGTGTGTGCCACCATGC CCTCTACACAGTTATGTTCAACTGGGCTC

CCAGCTAA I I I I I ATA I I I I I AATAGAGAT TCTGATACCAGCAGCAAGGTGGCGGGGT

GGAGCATTGCTGTAGCAGGACAAGCCAC TTAGGTTGTTGCAAACTTCAATGGTTATG

AAACAAAACCCCTCAGACACTGAGTTAAA CGAGGATTTTCACATAGCAAGCTTTGGTA

GAAGGAAGGGCTTTATTCGGCCAGGAGC CTTGGTTAATCTAGCATTTGTTAACCAAT

TTCAGCAAGAGTCATGTCTCCAATGACC GATGTCCTTTGGTAGTCATTAAAGTTACC

GAGCTCTCCAAGTGAGCAATTCCTGTCC ACAGCATGGGTGGCCTGTATATTCAGGT

CΓΠTAAGGGCTCACAACTCTAAGTGGGT TTTGCCCAAGGGTTAGTTTATCTGCTTCT

CCACATGAGAGGGTCGTGATTGATTGAG TGTGCTAACACGGCTGTTGCTGCCAGGG rs4793514 17 66430037 TTAAAATAAGCAAGTATTGCCTAAGGATA C/T TCAGAGCACAATGAGAATTTGGATCACAT S EQ_0715

TATAGACAAATGGAAAACAGCACTTCGCT TGCTCATTCTCCTCATTTTACAGATAAGG ATGTTACAAGGGTTGGCATGGTGCTGGA AAAGTGAAGCTTCCAGAAATTAAATCATC ATTGACTGGGAGCTGCATAATTTTCAACT ATCATGTACATAAAGTCAACATACATAAT TTGCTATCTACAGGCTCCTGTTCCACCTC TACAACTAATTAGTGGCCAACCACATGCT TATGA I I I I I I I GCTTCATCATTTACCTTT AGGAACCTCCATATTTACATATTCAGCAG CTGATCCTTGATAACAGTCATTGTTT TATGTGCCAGAGGCATCCTCAGCACT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7223685 17 66500336 AGTATCAAGAAAAGCTTTGAACTAAAAAC A/T TTGTTCAAATTAGTTCTCGACAGATAATG SEQ_0716

AGAAGAGAAAAAAGAATGATAAATATTTA GAAGGCTTTGATGTCCAAGCTAACGAAC

GTATTMGTCTCTAACATATAAAAAATTTG TGAAAATGAAAGTAGTCATTTCTATCTTC

GTTAATGAATGAATAATTGGGAAAATAAT TTAAAGTTTGATATGGTTTGGCTGTGTCC

TGAGACTAGGGAGCAAAACAAACAAATT CTACCCAAGTCTCATCTTGAATTGTTGTT

ATGCAAGTTGTAGCATATGGGGGAACTG CCCATAATCCCCATGTGTCATGGGATGG

TGCATCTGGCTAGAGAAAAATGTTTAT ACCCTGTGGGAGGTAATTGAATCATGGG

GGTGGTTACCCTCATGCTGTTCTCAAGAT

AGTGAGTTATCACGAGATCTGATGATTTT

ATAAGGGGCTCTTCCTCC I I I I I CTTGGC

ACTTCTCCTTGCTGCTGCCATGTGAAGAA

GGACGTGTTTGCTTCCCCTTCTGCCATG

TTTGTAAGTTTCCTGAGGCCTCCTCAGCC

ATGCTGAACTGTGAGTCAATCAAACCTCT

TTCCTTTGTAAATTACCCAGGCTCGCGTA

TGTCTTTATCAGCAGCATGAGTACAGACT

AATACCATGTTCTTAGAGAACCTTGTCTA

ATTACAATATTCTATGATCCTGGATGTCA

TACAAATCCCTGG I I I I I AAAGTCTGAAT £

AGTTTTCTCCCACAACTTGTTTTA ^

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1005316 17 66501964 AGGTTTCTTGTGAAATGTCGGCATTAATG A/G CCTGTGTCCAACTTGTCACGTTGACTGAA SEQ_0717 AAATTTTAATCAGTTTGTTTATCTAAGGAA ATTAAGCAATACTTAATGAGATCTCTCAT GAATTATTTGCATATCATATTGCAGAAAA GGGACCTCTCTCATATTTTACAGAACTGC TATAGTACTATAGTAAAGTTACCTGACTT CCATCTTTCTCATCTCCACACCTCCTGAA TAGACTATTATTTAAGTGAATCACTTGTAT ATGTCATTCTTCCATCTAATTTGGAGTAA CTTAATTTTCTTAGACAATTTATAGTCTTT GTTGTTATTTATGGATTGTTTTAAATTTAT GG I I I I IATCAG GAAGTGGTGAGGGGTGTTATAGTTAGCT GGATGTCCCTGTGAAGTTCCACAGATCA GTGGTGAAGCCATCCATTTACCAATTGAC TTTTAACCTTCTCTAGCTGACAAAATGTG ATTTATTTTCGTGCAAAGAAAATGAGCTA AATGTTTGACTATAGCCAGG I M I I I CTT GTAGCCTGAGTATATTGCACCTGAAAATC AGCTATTTCCTCAAAATATAACATAGATC AAGGTTAGTGTTTTCCATGAAAGAAACCA TAGGACATTAATGGTTACAGGTGGAATAT GTATTTTTATTGCACTTTATGTTGGTAATT TCCAAATCAGTTTCCATCTTGGAATAATT GTTTTATATGCACATTATAACCTACAACA GTACTAAGATTTTCTTCACTACCAAAATTT K* ATTGTCTTCCGGAGCTTATCCTGAAGCTT AGTATAAGTAGCATTCAAATAGAAATGAG ATAGAGTAAAAGAGATTTGCTTCGTGAGA ACGGAAGTCTATATATGGGATTAAAAGTT ATATAAATTATTATTTGAGCAAGGATTTAT TGAAACCTCCAAACTCACTTACCATTGTA CCAATATTGTTTTATTAAGAATCCAAGATT GTACAATGTTAGCATATTTGAATGCTTAA T rs8080412 17 66508046 ATCTTTTCAGCTCATCTTCCGAGCTGAAA A/C ATCCCAGACCAATGTTGTACAGGAGACT SEQ_0718 AGGCAGCTGACTGTAATAGGAATGGCAA TTGGATAAATAAATACACCACTCTTCTGT CTTGGCTGAAAACAGAAATCTCTCCCTTT TCCCCAATGGAGAAGATGTATGCTACAT CAGCCCCAGCTCTmπrCTGCCACAATTG GGCTCCTTAGAGTGTCATTAGTGAGACC TAGGATTATTGGTGAAACCACTCAGCCA AAGCCCCAGTTGTCCATTGAGTTACCAG CTGTGACACATGCACAAATCTAGACACG TTAAGTAAGAGATCTTAAGACTGCATTTT CAAGTGAATTAATACCCTTGATCAAAGGC CCTCTTTTCTTGTTCCGGTCTTCCAAGTT C

Supplementary Table 3

NP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs758022 17 66518601 CTCCATCTGTTTTCCACCCACACAATTTG CH ATTCGCGTTGAGGTAGTACAGTAATGAC SEQ_0719 CTCACTACAGTTAATAGGAAGCTGTGGT AAGGCACTGTGTGACCTCATGTAAGTGG GTACTTCTTGTGCTTCATAGCTCTAGAAT GATCCAATACCACTCAGGTGAACAAAAG AGAGAACATGAGATTACGA CTTTCTCTAACTTTACACAGTTTCACGAA TAGGATTTTTTATACTCTTTGGACTCTTCT AATGCAGGAAAGGCTTACAGCTGTGGCA ACGGCCAGCCATGTCTTTGGCCTTAGCT GGACAAGCGGTCCAGTGGATAATCTGAA CTACATCAGGGTGCATGTTGAGTTTGAAA GGGAGGGCTGCCTGGGAGCGGTGGCTC ACGTCTGTAATCCCAGAACTTTGGGAGG CCGAGGCGGAGGGATCACCTGAGGTCG GGAGTTGGAGACCAGCCTGACCAACACG GAGAAACCCCATCTCTACTAAAAATACAA AATTAGCCGGGCGTGGTGGCGCATGCCT GTAATCCCAGCTACTCGGGAGGCAGACG CAGGAGAATTGTTTGAATCTGGGAGGCT GAGATTGCGGTGAGCCAAGATCGCGCCA TTGCACTC rs 12983082 19 11077561 CCCTGGGCTCCCCCAGGTGTGGGACAT AJC CTGTTTGGAAGGTGCTGGTTG I I I I I I GT SEQ_0720 GCAGTGATTTAGGTGCCGAAGTGGATTT TGTTTGTTGTTTTTGTTTTTGTTTTTGTTTT CCAACAACATGCCAAGAAAGTATTCCCAT GAGACGGAGTCTCGCTCTGTCGCCAGG TTCATGTTTGTTTC I I I I I I I I C I I I I CTTT GTGGAGTGCAGTGGCGCGATCAGCTCA CTTTATTTTG I I I I I GAGATGGAGTCTCA CTGCAACCTCCGCTTCCTGGGTTCAAGC CTCTGTGAI I I I I I I CATCTCTAAATTTCC CATTCTCCTGCCTCAGCCTCCCAAGTAG TACATCCATATGGCCACCATGAGGCCCC CGCGGATTACAGGCATGTGCCACCACCT AGGCTGGCCGATGGTTGCTGTTAGCTTA CCGGCTA I I I I I I I I I CTATTTAGTAGAGA TTGGGAAATC TGGGGTTTCACCATGTTAGTCAGGCTGG TCATGAACTCTTGACCTCAGGTGATCCAC CCGCCTCGGCCTCCCAAAGTGCTGGGAT TACAGGCGTGCACTGCTGCACCCAGCCT TTTTTTGTTTTTTTGAGACAGGGTCTTGC TGTCACCCAGGTTGAAGTAAGGTGGCAC GATTATGGCTCACTGCGGCCTTGATCTC CTTGGCTCAAGCGATCCTCTCACTTCAG CCTCTCAAGCAGTTGGAACCACAGGCTG TACCACCAAGCCTGGCCA

Supplementary Table 3

SNP Chr Position 5¹ Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1003723 19 11085181 CGACACCTGCAGCCAGCTCTGCGTGAAC C/T GCTGATGCCCTTCTCTCCTCCTGCCTCA SEQ_0721

CTGGAGGGTGGCTACAAGTGCCAGTGTG GCACCCAGCTTGACAGAGCCCACGGCG

AGGAAGGCTTCCAGCTGGACCCCCACAC TCTCTTCCTATGACACCGTCATCAGCAG

GAAGGCCTGCAAGGCTGTGGGTGAGCA GGACATCCAGGCCCCCGACGGGCTGGC

CGGGAAGGCGGCGGGTGGGGGCGGCC TGTGGACT

TCACCCCTTGCAGGCAGCAGTGGTGGG

GGAGTTTCATCCTCTGAACTTTGCACAGA

CTCATATCCCCTGACCGGGAGGCTGTTT

GCTCCTGAGGGCTCTGGCAGGGGAGTC

TGCCGCCCTGTTAGGACTTGGGCTTGCC

AGGGGGATGCCTGCATATGTCCTAGTTT

TTGGGAATATCCAGTTAACGGAACCCTC

AGCCCTACTGGTGGAACAGGAACCGGCT

TTCCTTTCAGGGACAACCTGGGGAGTGA

CTTCAAGGGGTTAAAGAAAAAAAATTAGC

TGGGCATGGTGCCACACACCTGTGGTCC

CAGCTACTCAGAAGGCTGAGGCGGGAG

GATTGCTTGAGGGCAGGAGGATTGGTTG

ATCCTCCCACCTCAGCCTCCGGAGTAGC £

TGGGACCTCAGGTGCATGCCACTATGCC *-

TGGCTAA I I I I C I I I I I CC I I I I I I I I l I I I

TTTCGAGACGGAGTCTCGCTCTGTTGCC

CAGGCTGGAGTGCAGTGGCAGGATCTC

GGCTCACTGCAAGCTCCGCCTCCCGGGT

TCACGCCATTCTCCTGCCTCAGCCTCCC

CAGTAGCTGGGACTACAGGAGCCCGCC

ACTGCACCAGGCCAA I I I I I I I GTATTTT

TAGTAGAGACGGGGTTTCACTGTGTTAG

CCAGGATGGTCTCGATCTCCTGACTTCG

TGATCCGCCCACCTCGGCCTTCCAAAGT

GCTCGGATTACAGGCGTGAGCCACTGCG

CCCAGCCGCTAATTTTCATA I I I I IAGTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs5930 19 11085265 CGACACCTGCAGCCAGCTCTGCGTGAAC A/G GACATCCAGGCCCCCGACGGGCTGGCT SEQ_0722

CTGGAGGGTGGCTACAAGTGCCAGTGTG GTGGACT

AGGAAGGCTTCCAGCTGGACCCCCACAC

GAAGGCCTGCAAGGCTGTGGGTGAGCA

CGGGAAGGCGGCGGGTGGGGGCGGCC

TCACCCCTTGCAGGCAGCAGTGGTGGG

GGAGTTTCATCCTCTGAACTTTGCACAGA

CTCATATCCCCTGACCGGGAGGCTGTTT

GCTCCTGAGGGCTCTGGCAGGGGAGTC

TGCCGCCCTGTTAGGACTTGGGCTTGCC

AGGGGGATGCCTGCATATGTCCTAGTTT

TTGGGAATATCCAGTTAACGGAACCCTC

AGCCCTACTGGTGGAACAGGAACCGGCT

TTCCTTTCAGGGACAACCTGGGGAGTGA

CTTCAAGGGGTTAAAGAAAAAAAATTAGC

TGGGCATGGTGCCACACACCTGTGGTCC

CAGCTACTCAGAAGGCTGAGGCGGGAG

GATTGCTTGAGGGCAGGAGGATTGGTTG

ATCCTCCCACCTCAGCCTCCGGAGTAGC £

TGGGACCTCAGGTGCATGCCACTATGCC <^■"

TGGCTAA 1 1 i i C 1 1 1 1 i CC i i 1 1 1 i 1 1 1 1 1 1

TTTCGAGACGGAGTCTCGCTCTGTTGCC

CAGGCTGGAGTGCAGTGGCAGGATCTC

GGCTCACTGCAAGCTCCGCCTCCCGGGT

TCACGCCATTCTCCTGCCTCAGCCTCCC

CAGTAGCTGGGACTACAGGAGCCCGCC

ACTGCACCAGGCCAA I i I I I I I GTATTTT

TAGTAGAGACGGGGTTTCACTGTGTTAG

CCAGGATGGTCTCGATCTCCTGACTTCG

TGATCCGCCCACCTCGGCCTTCCAAAGT

GCTCGGATTACAGGCGTGAGCCACTGCG

CCCAGCCGCTAATTTTCATA I I I I I AGTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2738446 19 11088326 ATGGTGTGGACATCTACTCGCTGGTGAC C/G TGACCTGCAACTCCCCTACCTGCCCATT SEQ_0723

TGAAAACATTCAGTGGCCCAATGGCATC GGAGAGGGCGTCACAGGGGAGGGGTTC

ACCCTAGGTATGTTCGCAGGACAGCCGT AGGCTCACATGTGGTTGGAGCTGCCTCT

CCCAGCCAGGGCCGGGCACAGGCTGGA CCAGGTGCTTTTCTGCTAGGTCCCTGGC

GGACAGACGGGGGTTGCCAGGTGGCTC AGGGGGTCTTCCTGCCCGGAGCAGCGT

TGGGACAAGCCCAAGCTGCTCCCTGAAG GGCCAGGCCCTCAGGACCCTCTGGGAC

GTTTCCCTCTTTCTTTTCTTTG I I I I I I CT TGGCATCAGCACGTGACCTCTCCTTATC

I I I I I I GAGATGAGGTCTTGGTCTGTCAC CACTTGT

CCAGGCTGGAGTGCACTGGCGCAATCGT

AGCTCACTGCAGCCTCCACCTCCCAGGC

TCAAGTGATCCTCCTGCCTCACCCTCCT

GAGTAGCTGAGATTACAGACACGTGCCA

CCACGGCAGACTAATTTTATTTTA I I I I I G

GGAAGAGACAAAGTCTTGTTATGTTGGC

CTGGCTGGTCTCAAACTCAGGGTGCAΛG

CGATCCTCCCGCCTCAGCCTTCCAAACT

GCTGGGATTACAGGCGTGGGCCACCGT

ACCCAGCCTCCTTGAAG I I I I I rs688 19 11088602 CTGCCTCTCCAGGTGCTTTTCTGCTAGG C/T GGGGGCAACCGGAAGACCATCTTGGAG SEQ_0724 TCCCTGGCAGGGGGTCTTCCTGCCCGG GATGAAAAGAGGCTGGCCCACCCCTTCT AGCAGCGTGGCCAGGCCCTCAGGCCCC CCTTGGCCGTCTTTGAGGTGTGGCTTAC TCTGGGACTGGCATCAGCACGTGACCTC GTACGAGATGCAAGCACTTAGGTGGCGG TCCTTATCCACTTGTGTGTCTAGATCTCC ATAGACACAGACTATAGATCACTCAAGCC TCAGTGGCCGCCTCTACTGGGTTGACTC AAGATGAACGCAGAAAACTGGTTGTGAC CAAACTTCACTCCATCTCAAGCATCGATG TAGGAGGAGGTCTTAGACCTGAGTTATTT TCAA CTA rs2738452 19 11090218 TTTGGTTGTCACAAGTCAATGGGGAAGA A/G GTGTGTTCGTCCATTTGCATTGCAGTAAA SEQ_0725 CTGTTGGCATTTAGTGGGTAGAGGCTGG GGAATAGCTGAGGCCGGGTAATTTATAA TGACGCTGCTGAGCACCCAGAACAGGGA AGAAAAGAGATTTAAACTGGGTATGGCA AGTAGCAGGCCCTAGATAGAGCCATCGT GTTTATGCCTATAATCCCAGAACTTTGGG GGGGAAACCCTGCTCTAAGGAAATGGCG AGGCTGAGGCAGGGGGATCGCTTGAGT CTATTTTATAACCCCACGTTCCTGGCATG CCAGGAGTGTGAGACCGAGACCAGCCT ATTACCAACAGCCAAAAGTGGAGTCCCC GGCCAACATGACGAAACTCTGTCTCTAC CCA AAAA rs4804144 19 11097180 CTAAAAAAATACAAAAATTACCTGGGCAC A/C ATCACACTACAGCCAAGGCCTGGCCACT SEQ_0726 AGTGGTGGGTGCCTGTAATCCCAGCTAC TACTTTTGTAAATAAAGTTTTATTGGAGC TTGGGATGCTGAGGGTGGAGAATTGCTT CAGTGGACCAGTGAGGCCGAATCTTGCA GAACCTGGGAGGCAGAAGTTGCAGTAAG GGTGTAAGATCACAGTCTATCCTTGAAAA CCAAGATCATGCCACTGGACTCCAGCCT TTTTGATATTTTGTTCATTGGGTGGTTTTT CAGTGACAGAGCAAAACTCTGTCTCCAA CATTAATTTAAATTTTAAAAAATAACATAT AAAAATTG I I I I I I I I I I I I I I I I I I CAAAT TAAAGGCTGGTGTGGAGGTGCACGCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs2738459 19 11099473 CGCGATCTTGACTCACTGCAACTCCATTT A/C CAAAAAGAACCTTCTTAAACCGGAATTGA 0727

CCCGGGTTCAAGTGATTCTCCTCCCTCA GTCCTACAACCTCGATAACTCACAAATAA

GCCTCCCAAGTAGCTGGGATTACAGGTG GCCCGTGTGGCCTCTCACAGACTTGGGA CATGCCACCACGGCCAGCTAATΠTGTAT AGTTCTCCAAGTGTCCAGGGAGATGTGC TTTTAGTAGAGACAGGGTTTCACTATGTT CAGGCGCTTTCCTGCCGTGACCACCGTC GATCATGCTGGTCTCAAACTCCTGACCTT CTCTGCCTGCTCCATTTCTTGGTGGCCTT AGGTGATCTGCCCGCCTTAGCCTCCCAA CCTTTAGACCTGGGCCTCACTCTTGCTTC AGTGTTGGGATTACAGGTGTGAGCCACC TCTCCTGCA GCGCCCAGACCAAAATATGCTCATTTTAA

TAAAATGCACAAGTAGGTTGACAAGAATT

TCACCTGCAACCTTGTCAACCACCTAGAA

TAAAAGCCTCTGCAGCCCTCCCCTAAAG

ACTCATCAATGTGAGGCTCAAGAACCTTC

TTAGGCTGGGCTCGGTGGCTCATTTCTG

TAATCCCTGCACTTTGGAAGGCTGAGGC

AGGAGGATCTCTTGAGGCCAGGAGTTCA

AGACAAGCCTGGGCAACATAGCCAGACC

TCTGTTTCTATCCCCC

RS12459476 19 11099492 AACTCCATTTCCCGGGTTCAAGTGATTCT A/G CCGGAATTGAGTCCTACAACCTCGATAA SEQ 0728

CCTCCCTCAGCCTCCCAAGTAGCTGGGA CTCACAAATAAGCCCGTGTGGCCTCTCA TTACAGGTGCATGCCACCACGGCCAGCT CAGACTTGGGAAGTTCTCCAAGTGTCCA AATTTTGTATTTTTAGTAGAGACAGGGTT GGGAGATGTGCCAGGCGCTTTCCTGCC TCACTATGTTGATCATGCTGGTCTCAAAC GTGACCACCGTCCTCTGCCTGCTCCATT TCCTGACCTTAGGTGATCTGCCCGCCTT TCTTGGTGGCCTTCCTTTAGACCTGGGC AGCCTCCCAAAGTGTTGGGATTACAGGT CTCACTCTTGCrrCTCTCCTGCAGCTCTG GTGAGCCACCGCGCCCAGACCAAAATAT GGCG GCTCATΠTAATAAAATGCACAAGTAGGT

TGACAAGAATTTCACCTGCAACCTTGTCA

ACCACCTAGAATAAAAGCCTCTGCAGCC

CTCCCCTAAAGACTCATCAATGTGAGGC

TCAAGAACCTTCTTAGGCTGGGCTCGGT

GGCTCATTTCTGTAATCCCTGCACTTTGG

AAGGCTGAGGCAGGAGGATCTCTTGAGG

CCAGGAGTTCAAGACAAGCCTGGGCAAC

ATAGCCAGACCTCTGTTTCTATCCCCCAC

AAAAAGAACCTTCTTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6413504 19 11102915 GAGGGCCAGGAGGGAGGAAGGGAGAG A/G TGCTGGACTGATAGTTTCCGCTGTTTACC SEQ_0729

GAGGTGTTTTA I I I I I I I GCTTTTA I I I I I ATTTGTTGGCAGAGACAGATGGTCAGTC

TATTTTGAGACAGAGTCTCTCTCTGTCAC TGGAGGATGACGTGGCGTGAACATCTGC

CCAGGTTGGAGTGCAGTGCTGTGATCTT CTGGAGTCCCGTCCCTGCCCAGAACCCT

GGCTCACTGCAACTTCTGCCTCCTGGGT TCCTGAGACCTCGCCGGCCTTGTΠΓTATT

TCAAGCAATTCTTATGCCTCAGCCTCAGC CAAAGACAGAGAAGACCAAAGCATTGCC

CTCCTGAGTAGCTGGGATTACAACACTAT TGCCAGAGCTTTGTTTTATATATTTATTCA

GCCCGGGTAA I I I I I GTA I I I I IAGTAGA

GACGAGGTTTCGCCATGTTGCCCAGACT

GGTCTCGAACTCCTGACCTCAAGTGATC

CACCCGCCTTGGCCTCCCCACGTGCTGG

GATTGCAGGCGTGAGCCACTGCGCCCG

CCTTGATCTTTACACAAGGGGTTTAGGGT

AGGTAGCCTTCTCTGAACCAGGAGAACA

GCCTGTGCGAAGGCCCTGAGGCTGGAC

CGTGCCTGTTGGGTTTGAGGCCGTTGTA

GCTGGAGCAAACAGAGAGAGGGGTAAAA

AGGCAGGAGGCTACCAGGCAGGTTGTG

CAGAGCCTTGTGGGCCACTGGGGAGGA &

CTTTGGCTTTTGCCCTGAGAGCGGTGGG ^∞

AAGTGACTGAATCCGGTACTCACCGTCT

CCCTCTGGCGGCTCCTGGGGGAACATG

CTTGGGGATCAGGCTGGGGGAGGCTGC

CAGGCCCAGGAGGTGAGAAGTAGGTGG

CCTCCAGCCGTGTTTCCTGA r_e4804147 19 11117285 GGTGTGCACGCCTCCTTTCCTTAGCGGT A/G TAAGTTTGTGCTGATATCTGGCTCTGCCA SEQ_0730

ACCCAAAACACCGAGGATGGGAGAGTGA TCATCAGGGAACCAGGCTCCTGTCATCC

TGAACACATTGATTGGCCGGCCCTGGAC CTAAAGGACGGCACTCGTCTGTACACGT

TGGAGTACATGTTCAGTTAGGGTTTATTT GGCAGTATGGCTGCCAGGGCTCCAGCC

TGGTATCTGTCATAGAAAACCCCCAAAAC ATCACACCCACATTCCAGGAAATAGGAA

CAGCAGCTTACACAAGGTAGAAGTTGAG GGGGGAAGAAAGGGTGTATTTGTCTTTT

ATTGGTTCTCCCCTTCTCTCTCCCATTTA AAGAATCCTTCTAGAAGTGTCATGTAACA

A TTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs8Ϊ01509 19 57100638 CCTATGGCGGCGGACGAGGGCGCGAGT G/T TCTGGTCTGCATTTTAATTTTGCTTTGAC SEQJ5731

CAATTCTGCCGCGCTAGGACGATGGGAC ACAGGAGACAGTGAAATGGCACTGATGT

ATGGGCTTCTCTTCGAGGAGGTAACATG GTTCCCTCTCCTGACACCTCAACCCCTG

TCCGCGCCCTGAGCCACGGCTCTCTGG CACTGTGAGGTTGGAGCACTAACAACAG

GCGCGGCCATCTTGGTAGATCTGCCGTA TGCACTGTGGGGAAAAGAAAGAGAGATC

CAGAAGGGAAACAGTTGTTCTTGTGTCAT AGACTGTTACTGTGTCTATGTAGAAAGAA

TAAACCGGGATGACTCTCCTGAAAGCAA GTAGACATAAGAGACTCCATTTTGTTCCG

AAATTTGAGGCGCAGGAGCATTTTCTAG TACTAAGAAAAATTCTTCTGCCTTGAGAT

AGTTTATCTGAACAAACAGCAATTCATGA GCTGTTAATCTGTAACCCTACCCCCAACC

ATTAGGAAGCATCAAACCAAAAGAAGTCT CTGTTCTCACAGAGACGTGTGCTGTGTT

CGCGCTTCTATGCTTAAAGCATTAGACAC GACTCMGGTTTAATGGATTTAGGGCTAT

AAGTATTCACAGGGTGAGTGAAGGAGTA GCAGGATGTGCTTTGTTAAACAAATGCTT

AAACAAAGAAATTATTTGATTAGTTACAAT GAAGGCAGTATGCTTGTTAAAAGTCATCA

TATAAAAATGCAI I I I 1 1 1 AAATTTGCCTT CCACTCTCTAATCTCAAGTACCCAGGGA

GGAAAGTCCCTAATGACATAATAGCATGT CACAATACACTGCGGAAGGCCACAGGGA

GAGTTGCCTACTΠTGATCGGTTGAGATT CCTCTGCCCCAGAAAGCCAGGTATTATC

GAGTTTTGTCCTTCCCTAACACAAGCATT CAAGGTTTCTCCCCATGTGATAGTCTGAA

TACCAGAAATGACTCAAGTGAATTGTTGC ATATGGCCTCGTGGGAAGGGAAAGACCT

TTATGTTTGCAGGTTAAGCAAGGTTAAGG GACCATCCCTCAGCCCGACACCCGTAAA £

CTG I I I I I AAGGCCTACTGGGTTTTGTTT GGGTCTGTGCTGAGGAGGATTAGTATAA ^

GCTCAGGAG I I I I I GAA GAGGAAGGAAGGCCTCTTGCAGTTGAGA

CAAGAGGAAGGCATCTGTCTCCTGCTCG

TCCCTGGGCAATGGAATGTCTCGGTATA

AAACCCGATTGTATGTTCCATCTACTGAG

ATAGGAGAAAATCGCCTTAGGGCTGGAG

GTGAGACAAGCTGGCGGCAATACTGCTC

TTTAATGCACCGAGACGTTTATGTATGTG

CATATCAAAGCACAGCACCTTCTTCTTAA

GCTTGTTTATGACACAGAGACATTTGTTC

ACATGTTTTCCTGCTGACACTCTCCCCAC

TATTATCCTATTGTCCTGCCACATCCCCC

TCTCCGAGATGGTAGAGATAATGATCAAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs13343310 19 57125279 C I I I I I I I C I I I I I ATAGAGATGGCATCTC C/T GCTACAATATAATATGTGATCTTTTGTGA SEQ_0732

ACTATGTTGcccAGGCTGATCTTGAACTC CTGGTTTCTTTCACATAGCATAA I I I I Π I

CTGACCTCAAGTGATCCTCTCTCCTTGG I I I I I I GAGACAGAGTCTTACTCTGTCAC

CCTCCTAAAGTGCTGGGATTCCAGGTGT CCAGGCTAGAATGCAGTGGCGTGATCTC

GAGCCACTTCACCCAGCCACATTTATCC AGCTCACTGCAACCACCACCTCCCAAGT

ATCTTGTAAAATATTGCTTTG I I I I I I GGT TCAAGTGATTCTCCTGCCTCAGCCTCCC

GCATTTCAAAGTAAGTTGCAGACATTCAT AAGTAGCTGAGATTACAGGTGCCTGCTA

ACATTTGCCCCTGAATATTTCAGTAGGTT CCATGCATGGCTAA I I I I I GTA I I I I I GG

TATCATAATTAAGTTCTACTGACAGCTTTT TAGAGACGGGGTTTTGCCACGTTGGCCA

CCTAATTACAGGTCTATTAGTCCCATACT GGCTGGTCTCAAACTCCTGACCTCAGCT

GTATAATTCAGTGGCTTTTACTATGTGCG GATCCGCCCACCTCAGCCTCCCAAAGTG

GCCATCACCAAAGTCAACTTTAGAACATT CTGAGATTACAGGCGTGAGCCACTGCGC

TTCATCACTTAAAAAGAAACCCTGTACCC CCAGCCAACATAGTATAATGTTTTCAAGG

TTTTGTTACCACTCCCTATGCCCTACCAC TTTGTCTGTGTCGTAGCATGTATCTGTAC

TAAGTAATCTCTAATCTACTTTCTGTCTCT TTCATTC I I I I I IATGCCAGAATAGTATTT

ATAGATTTGCTTATTTTGACCTTTCTGTrT CATGGTATGGATATGGCATCTTGTATTTA

TCTTCTAATTTACTCTTATTTCATTTCATG TCCTTTCATCAGTTGATGGACTTTTGGGT

TAAA TATTTCCCCTTTT

4-

O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7254374 19 57127279 ATTGATTATTTATACTTGATTCTTTATCAA A/G TGATAAACAGTTTGCTGTTTGATCATGTA SEQJD733

ACTAACTGGGTAGCCTTTCCAGAATAGTT CTCTCCAGTGGAATGCTGAGTTGGTCAC

AAAATAGTGATAATCATCCTGTTCATCTT GATCCCTTTGGCCTTTTCGGCTCCCAAC

CGATATTGCTCTTGACTTTAGAGAATGTA ATC I I I I I I I I I I I I I I I I I I I I I I I I GAGA

CTTTTATAGTTTCATAGAAC I I I I I I I I CT CAGAGTTTCACTCTTGTTGCCCTGGCTA

TCATTCCTAGAACTTCTGTAGGATGTATT GAGTGCAATGGCTTGATCTCAGCTCACT

TAA I I I I l I AAAATGAGGTAAAATTCACAA GCAGCCTCTGCCTCCCGGGTTCAAGCAA

GACATAAAATTAATCATTTTAAAGTCAACA TTCTCCTGCCTCTGCTAGGATTACGGGC

GTGCAATCGTTCTTAGTACAGTCACAGTG ATGCGCCACCATGCCTGGCTAATTTTGTA

TTGTACAACCACCACTTGCAGCCACTTCA I I I I I I GTAGAGACCGGGTTTCTCCATGT

CATTCTCCCCTCCAGTAGACCCTGGCAA TGGTCGGGCTAGTCTCGAACTCCCGATC

CCAACTATGTGCTTTCCGTCTC I I I I I GT TCAGGTGATCTGCCCGCCTCGGCCTCCC

AGAGTGCCCGATTCTGTCGCTGTTTGGG AAAGTCCTGGGATTACAGGCGTGAGCCA

GCGCCAGTTGTAACTGACCATGATTCCT CCGCACCAGGCCAGTGTGCTGTCTGTAT

GGTAGACTGAACAAAGCGGGGCAAACGA GCATTTACCTAATCTGGGTATTTTATATAA

GGGAATAAAAGACAAAAACAAAAGAGTAT ATGAAATCATATAACGTGACATTTAGTGT

ATTTGGAAGAAGGGGTCAGGGGGCACCT CTGACATTTTC I I I I I I I I I I I GAGACAGG

TGCCTCTAGTGGATAAGGGCTCTGAGCT GTCTCACTCTATTGCCCAGGCTGGAGCG

TTACACAGCTCTCCGTATTTATTAGGCAA CATTGGCACACTCTTGGCTCACTGCAAA ^

AAGAGATAGAGAGAAGGGGGGGTGATT CTCTGCCTCCTGGGCTCAAGCAATTCTC ^

GTCGAGTAATTGTCAGTCGGCCTTTTGG ATACCTCAGCCACCCTAACAGCTGGGAT

TTCACAGCAGGCTTGTGAGATTGCATTC TATAGGCATGCACCACCATGCCTGGCTA

CTTGAGCAATAGCCTCTAGATGTCCCCAT AI I I I I GAAC M i l l GTAGAGATGGGGTT

AGATAGCCTCCAGGAGCCCAGCGCCAG TCCTCATGTTGCCCTGGCTGGTCAAGAG

GGAATGGTGGCCCTCAGCAAAGCTGGG TTTATCTTGAGCTCAAAGCAATCCTCCTG

GCAGGTACAGAAGCGAGTTTGCCCACAT CCTTGGCCTCCCAAAGTGCTAGGATTAC

TCTGTACTC AGGTGTGAGCCACCACGCCTGAGTGTCT

GACATTTTCACTTAGCATAATG I I I I I GT

GGTTGTGGATTGTGTGCTGGGCTACTCC

TTTAATGATTAGCCAGGGAATCTATAAAC

CTGCCTTACCGTTCACTTCCTGCTTGCAC

TGAACCTGTAGACATCAGCCAGAAGGAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11670350 19 57129400 GTCACCCAGACTGGAGTGCAGTGGTGTG GfT TTGGTACTTTTAAAAAAGAAATAAACTGA SEQ_0734

ATCTCAGCTCACTGCAACCTCCACCTGC TGCAAGTGCACCTTCAGTGATATCCTCTA

CAGGTTCAAATGATTCTCCTGCCTCAGC ATCCACCCCCTTTCCTCTCCTCCATCCCT

CTCTTGAGTAGCTGGGACTACAGACATG AGGGATAACTATTCCCTTGAACTAATTTC

TGCCACCACACCTGGCTAC M i l l GTAGT ATATAATGCATGTTTTATTAAATGTGTACA

TTTAGTAGAGATGGGGTTTCACCATGTTG TATTGAAAAATAATACATAGTCTTATTTTA

GCCTGGCTGGTCTTGAACTTCTGGCCTC TG I I I I I IAA I I I I I IAAATATACTTTTCTT

AAGTGATCCTCTGGCCTCAGCCTCCCAA TGTTGTTTCTTTCATATGATGATG

AGTGCTGGGATTATAGGCAAGCATGAGC

CACCATGCCCGGCCAGTCACC I I I I I I I I

GACTCAATATTTGTTCTGTTGTTGTAAAC

CTTTGACTATTTTTCAGAGTTCTGACCAA

G I I I I I G I I I I I I GATTG I I I I FACTTGAT

I I I I I GATAG I I I I I I I ACTTGAG I I I l I G

A I I I i I CGATAGAGGGACGGACCCTTGG

ACCTACCTACTCTGCCA I I I I I ACTCAAT

GAGATTTTCCTCCACAGTATATATGCTTT

TGTTTTTTTTGTT rs919779 19 57130159 TGGGTTAAAGGATGAGTCAGTGCAGACC CfT AGGGTGACTCCATCCAGTTGATGCTCTC SEQ_0735 ^

CTGTGGGTTTGGAGCATGCAGGAGGGC ACCATGTGAGCCTCTTACTTGAGTΠTAG ^

CACCGGGAGCTTGTCACAATGATTCCAC AATTGGGCATAAAAAAAGCCTCTGGGGC

CCAGGTGGAAGGAAAGCT CGCCACTCTCTGACCTGCTGCTTTCAGG

CCAAGGGTGTAGCGTGCAG I I Tl I CCAT

TTGTCTTTGTGCCTGTGTCACTGTTGGCA

GTGCTGATTTCAGAAGGTCAGATTATATG

TCTATGACAGTGGCCATCTTCCATGATGA

ATGAAACTCCCTCAAGGTAGTAGCAAAG

AGAGCTAAGATGTATGATGATGGTATGC

AGTCCAAAGGTATTCAGCAGAGGCTAAG

GTCATGTTCTTGGAGACAGGCTGTGTGG

GTTCAGATTCTACTTCTGCTTTTGGACAA

TATAGTCAAATCTGTAAGCCTTAGGTCAA

TGTTGGAATGGGAAATAATGATTGATACT

TTATAAGGATGTAACGCAGAAGGTAGTAA

TGAGAATTCAAATACAACAACCCCTCTGC

TTGGCTTAATACATTTGTCTTCAAACTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11672744 19 57145574 CACTTCTGA I I I I I ATTTAGGAGCA I I I I I C/T GGAGTCACATTAAATGTTTGCCTTAATTA SEQ_0736

I l I I I CGTTTCATCCTCACAGTTTTCACAA GGATGGAATTGACATGTATAAAATATTCA

TTGCAATACTTTGGGTAAATATTTGATTTC ATTCTATTTCTATATTTTCTATCTATATATA

ATCACTTAAATTCTCATCACAAACATACAT ACATTCTGATACTCCAATTACTCAAGTTC

ACATGTATGTATATATAGTATATATATCTA TTCTGTTCCCACCCCAAGATTTGTGATTC

TATTTCTGTCTCTATATACATCTGTCTATG AC I I I I l I ATGTCCTAGATCTTATGGTTAC

TATGTATGTATGTATCTATCTATCTATCTA ATTTATTCTTAAGTGGCTTATAC

TCTATCTATCTATCTATCTATCTATCTATC

TATCTTTCTATACAGAGAGAGTCAGTCTT

GCCCTGTCTCCCAGGCTGGAGTACAATG

GTGCCATCAGCTCACTCTAACCTTGAACT

CCTGGGTTTAAGGGATCCTCCTGCCTCA

GCCTCCCAAGTAGCTGGACTACATATAA

AATTΠTCAATGGCAGTATCACATCAGAA

GGTTGTACCAGTGGCTTAGTAAA

4- <I

W

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1017379 19 57149118 CTTCATTCTGTATCATCAAACTMTTTTCC C/T TTCTATAATTCTACAATTATGTCTTGGTTG SEQ_0737

CAAAGCACCAATCTCACATTTAGAGAGAA GCATCACAAAAGGGGCCTAAGGGACCAC ACTTATTCTCAGTGTCCAACCTTTAGCCT CTTATTCCTTTTAAACCAAGACTCATGCC CACTGTGGGCACATTCTCCTGTGCTTCTA ACCTTTACATATTTCTTAGAMGGAGGAT AAGAAAGAGGGAAAGATGAGAAACAATG ATATAATGGAGGAAGACAAGGCTCACCG ATCATTTGGAAAGTTTGCAACAGGCCAAT ATGAGTTCAAAACAAGGGGACGAAGAAA GAACCATGTAGACCTCTCCAGAAGCAGA GTGAGGAATTAAGGTTTGCTCCTAAGTAT TGTGCTTCTGAATAGGATAAGATGTGTTA TTTGCTTGAGTCAAGAGAC I I I I I I I I I G CTGAATGGGTGCTACTGCTGGTGCCCAC AAAGATATATTTAACATTTTACATTATGTA ATGTGTTGTCTGTCACCTTCAGTCACATT TATAATAGTCAAAAAGTCTTTTATCTCAGT TGGCATGTAGTACCTACACAGATGTCAG CAATGAATATTTTATTTCAGTGAAAGGGT ATCTGAATTTTTCCCATTTCATTGTCCCTA CTTATATATCGGGGACATCTGGCCTGGG ATACACTGATCCCTTGTCATGTAACTAAT ATCTAGGAAACATGGAAGGAAATTAATCT AGCAT GTAATAAAGTGTTAGTAATTAAGAGGTCA

AGCTCTATGACTCAGTCTCCAAAGTCAAC

TTTCCTCAAGTCCTAATAACTΠTAGACG

CCCCCAATATACAGACTATTTTCTTTTAG

GCTCAACTTTCTTTACATAAGACATGTGA

4-

ATCCACACGTCTATGCCTTCTACATTTTA 4-

GTGCAAGGATTAGTAAAAAGTAACTAATA

GAGCGCTTTCCAGTTTGGTTAAAGGGAG

TCCTTTAACCAAATATCATTTTAGATATCA

TTTCCAGTAGAAAAAAATCTCCTGGCTGA

AGTTCATGGGTTTTAAGTTCTTTGTTTCC

TGGGAGTTCACTATAAAAAGAGTC I I I I I

TCAAATTATGA I I I I IAGGTAGTTGTTTTA

TAAAGATGTCAGAAAAATTTAATATGTCTT

CTTTTAGCATTATGGATTTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2015845 19 57149591 CTTCATTCTGTATCATCAAACTAATTTTCC G/T ACAGACTATTTTCTTTTAGGCTCAACTTT SEQ_0738

CAAAGCACCAATCTCACATTTAGAGAGAA CTTTACATAAGACATGTGAATCCACACGT

ACTTATTCTCAGTGTCCAACCTTTAGCCT CTATGCCTTCTACATTTTAGTGCAAGGAT

CACTGTGGGCACATTCTCCTGTGCTTCTA TAGTAAAAAGTAACTAATAGAGCGCTTTC

AAGAAAGAGGGAAAGATGAGAAACAATG CAGTTTGGTTAAAGGGAGTCCTTTAACCA

ATCATTTGGAAAGTTTGCAACAGGCCAAT AATATCATTTTAGATATCATTTCCAGTAGA

GAACCATGTAGACCTCTCCAGAAGCAGA AAAAAATCTCCTGGCTGAAGTTCATGGGT

TGTGCTTCTGAATAGGATAAGATGTGTTA TTTAAGTTCTTTGTTTCCTGGGAGTTCAC

CTGAATGGGTGCTACTGCTGGTGCCCAC TATAAAAAGAGTC I I I I I I CAAATTATGAT

ATGTGTTGTCTGTCACCTTCAGTCACATT TTTTAGGTAGTTGTTTTATAAAGATGTCA

TGGCATGTAGTACCTACACAGATGTCAG GAAAAATTTAATATGTCTTCTTTTAGCATT

ATCTGAATTTTTCCCATTTCATTGTCCCTA ATGGATTTA

ATACACTGATCCCTTGTCATGTAACTAAT

AGCATCTTCTATAATTCTACAATTATGTCT

TGGTTGGCATCACAAAAGGGGCCTAAGG

GACCACCTTATTCCTTTTAAACCAAGACT

CATGCCACCTTTACATATTTCTTAGAAAG

GAGGATATATAATGGAGGAAGACAAGGC ^

TCACCGATGAGTTCAAMCAAGGGGACG jJ

AAGAAAGTGAGGAATTAAGGTTTGCTCCT

AAGTATTTTGCTTGAGTCAAGAGACTTTT

TTTTTGAAAGATATATTTAACATTTTACAT

TATGTATATAATAGTCAAAMGTCTTTTAT

CTCAGTCMTGAATATTTTATTTCAGTGA

MGGGTCTTATATATCGGGGACATCTGG

CCTGGGATCTAGGAMCATGGMGGAM

TTMTCTGTAATAAAGTGTTAGTAATTAAG

AGGTCAAGCTCTATGACTCAGTCTCCAM

GTCAACTTTCCTCAAGTCCTMTMCTTT

TAGACGCCCCCAATA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs8109375 19 57151862 GTCCAGAAAGAAGTAAGACTTCTAAAGG C/T GGAGTGAATTTAGAAGTGCTTCCAGGCT SEQ 0739

GACTAGCTTGCTAACTAAGTAATTCTGAG GGGTGTGGTTGCTTATGCCTATAATCCTA CATGAAGTGAATTTAGAAGTGCTTCCAG GCACATTGCGAGGCTGAGGCAAGAGGC GCTGGCATGCTGGCTCATGCCTGTAATT TCTCTTGAGCTCGGGAATTTGAGACCAG CTAGCACTTTGGGAGGCCAAGGTGGGTA CCTGGGAAACATAAGGAGACACCCCTGC GATTCCTTGAACTCAGAAGTTCAAGACCA CTCCAGAAAAAAAATTTAAAACTTAGCCA GCCTGGGCAACATGGTGAAACCCCATCT GGCATGTTGGCATGCACCTGAAGTCCCA CTACTTAAAATACAAAAATTAGTCAGGGG CCTAGGTAGGAGGCTGAGGTGGGAAGA TGGTGGCAGGCACCTATAGTCCCTGCTA TTGCTTGAGCCCAGGAGGTTTACCAGTA CTCAGAGGCTGAGGTGGGAGGATGGCT GGGTGATTGCTGTATTAACCCCATGCAG TGAGCCCAGGAGGCGGAGGTTGCAGTG GCTGGTAGTCCTCTAGCCACTGAATCCA AGCCAAAATCACACCACTGCAGTCCAGC ACTGCTGACTGTTGTATTATATAGGTCTC CTGGGCAATAGAGCCAGACCCTGTCTCA TTTTGAGCCCCATG I I I I I GGGTCATAAT AAAAAAAAAAAAAAAAAAAAAAAGATTAT GCCTAGGGTATTTTCTTGATCTTCCTGTA GCAATCACGAGGCATTTCATTCAAATTTA CAAACAACGTAAACAAAATAATTTGGATT GGGGCAGTTTCATATGAGGTGAAGAAAG TCCTAGTACTGGGGCATCTATAAGATCCT AAGTAGGACTTCTAAAGGGACCAGCCTG TTAAATTGTTCCTAACATTAATTGA I I I I I CTAACTAAATATTTCTGAGTA CTCTGTCCAATCCAGAG rs7250159 19 57163215 GGAGATGTCAGTTTGGGACTCTCCTCCA ATf CACAGGGGAGGTGTTAGGAGGGGAGGT SEQ_0740

GGGAGCGGAAGGAGTTTAAACTTACTAG CAGCATTAGCCAAGGGGCACAAAGGGGT AATGAAGGCAATTTTGAAGAGTGAAGGG GGGAGTCCGAAAACAGTGAGGACTTCAA CACAGATGAGAAAATGGAGAACGGGACC AGTTTCCTCTTTGGAAAGAGGCCTGGAA TTTGGAGAACCTAAGAATAAGGAAAAAGA GGTGGAATTTCGTAACAAGAGAGGTGGA GAAGCGAAGGAAGCCAAGGCACAGCGA ACAACATGAAGAAGGGAAATACTTGAAA AAGTCCAGTTTACCCTGAGGAAGCCACA CCCGAGGAAGAAGAAAATTATGCAGGCA TCCA AACAA rs2278416 19 57163376 ACAGCGAAAGTCCAGTTTACCCTGAGGA C/T TTGAAACCCGAGGAAGAAGAAAATTATG SEQ_0741

AGCCACATCCATCACAGGGGAGGTGTTA CAGGCAAACAAACAATATGTAGATAAAAT GGAGGGGAGGTCAGCATTAGCCAAGGG AATCAGATCTCTGAGGAGATAAAGAGTTT GCACAAAGGGGTGGGAGTCCGAAAACA TTGTTTTGTTTTG I I I I I I I I IAACTCTAAA GTGAGGACTTCAAAGTTTCCTCTTTGGAA TTCCTACAAAGAAAAACTGGTCTCACACT AGAGGCCTGGAAGGTGGAATTTCGTAAC GGGAGACAGATGAGTAGAGGAACTGTTT AAGAGAGGTGGAACAACATGAAGAAGGG ACATATCCTCAAACCCCCTTCACAGCTGT AAATA GCTGCCTTCTCTGACTGTCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2278417 19 57163581 GAATTTCGTMCAAGAGAGGTGGAACΛA CfT TGCCTTCTCTGACTGTCTAGAATGTGACT SEQ_0742

CATGAAGAAGGGAAATACTTGAAACCCG TCCATAGCCTTCTGTCTTGTGGGTTCTCT AGGAAGAAGAAAATTATGCAGGCAAACA CACCTGAACAGGCTCCACTGTGGATTCC AACAATATGTAGATAAAATAATCAGATCT ATCTTCAATTGTCCACAGTTGTTCTCCTT CTGAGGAGATAAAGAG I I I I I GTTTTGTT GTTCCAACTTGAAGAGTGCATCCGGTTT TTG I I I I I I I I IAACTCTAAATTCCTACAA GCTGGCTTGATACCCTGTTCATGGAAAAT AGAAAAACTGGTCTCACACTGGGAGACA GATAGAGGACTTAGACATATCAAATTGG GATGAGTAGAGGAACTGTTTACATATCCT GCTGGCAATGTCAAGAAGGAAGAATGTT CAAACCCCCTTCACAGCTGTG ACATTTCAAGAAACTTGAGTTT rs2278418 19 57163597 GAGGTGGAACAACATGAAGAAGGGAAAT A/T CTAGAATGTGACTTCCATAGCCTTCTGTC SEQ_0743

ACTTGAAACCCGAGGAAGAAGAAAATTAT TTGTGGGTTCTCTCACCTGAACAGGCTC GCAGGCAAACAAACAATATGTAGATAAAA CACTGTGGATTCCATCTTCAATTGTCCAC TAATCAGATCTCTGAGGAGATAAAGAGTT AGTTGTTCTCCTTGTTCCAACTTGAAGAG TTTGTTTTGTTTTG I I I I I I I I IAACTCTAA TGCATCCGGTTTGCTGGCTTGATACCCT ATTCCTACAAAGAAAAACTGGTCTCACAC GTTCATGGAAAATGATAGAGGACTTAGA TGGGAGACAGATGAGTAGAGGAACTGTT CATATCAAATTGGGCTGGCAATGTCAAG TACATATCCTCAAACCCCCTTCACAGCTG AAGGAAGAATGTTACATTTCAAGAAACTT TGCTGCCTTCTCTGACTG GAGTTTCTTAAAATACCCAAAA rs2278419 19 57163625 ACTTGAAACCCGAGGAAGAAGAAAATTAT C/T CTTGTGGGTTCTCTCACCTGAACAGGCT SEQ_0744

GCAGGCAAACAAACAATATGTAGATAAAA CCACTGTGGATTCCATCTTCAATTGTCCA TAATCAGATCTCTGAGGAGATAAAGAGTT CAGTTGTTCTCCTTGTTCCAACTTGAAGA TTTGTTTTGTTTTG I I I I I I I I IAACTCTAA GTGCATCCGGTTTGCTGGCTTGATACCC ATTCCTACAAAGAAAAACTGGTCTCACAC TGTTCATGGAAAATGATAGAGGACTTAGA TGGGAGACAGATGAGTAGAGGAACTGTT CATATCAAATTGGGCTGGCAATGTCAAG TACATATCCTCAAACCCCCTTCACAGCTG AAGGAAGAATGTTACATTTCAAGAAACTT TGCTGCCTTCTCTGACTGTCTAGAATGTG GAGTTTCTTAAAATACCCAAAATTTAGTTT ACTTCCATAGCCTTCTG CTTATCTGAAACTATGAAAG rs2278420 19 57163684 I I I I I GTTTTGTTTTGT I I i I Tl I I AACTCT A/G GTTGTTCTCCTTGTTCCAACTTGAAGAGT SEQ_0745

AAATTCCTACAAAGAAAAACTGGTCTCAC GCATCCGGTTTGCTGGCTTGATACCCTG ACTGGGAGACAGATGAGTAGAGGAACTG TTCATGGAAAATGATAGAGGACTTAGACA TTTACATATCCTCAAACCCCCTTCACAGC TATCAAATTGGGCTGGCAATGTCAAGAA TGTGCTGCCTTCTCTGACTGTCTAGAATG GGAAGAATGTTACATTTCAAGAAACTTGA TGACTTCCATAGCCTTCTGTCTTGTGGGT GTTTCTTAAMTACCCAAAATTTAGTTTCT TCTCTCACCTGAACAGGCTCCACTGTGG TATCTGAAACTATGAAAGTTTCGTTTC ATTCCATCTTCAATTGTCCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7253957 19 57165635 GGAAGAAATGCTAAAG I I I I I CTGCTCAT A/C ATATATCACAAATCCAGGCCTCCTATTTT SEQ_0746

TTCCACTCTACAGGCTGTGTGCATATACC TCTGATGGACTAATTATAAACTGAGGGTT

AAATAG I I I I I I I I I I AATACAATGTGGAA CCTATGACCTCCTTGAGTTTGATAATTTC

GAAGTAAAGTCCTAATATAATATTCTGTA TCAAGAAGAAGGAGAAAATCAAGTAATG

ACTGTATATTCAGTCATCCTCCATTCACC GAGAAACAATATCCAAAGATCTAACACTG

CAATTGGAAGTTTCTATAAAGTGTAGAAG AAAATTTTTCAGAACTGATTAAACACTCC

TTAAATCTTGCTAACCTAAAAACAATATAT AAAATTCAAACTCAAGAAATCCAACAACT

TTATACATTTTATATATGTAAATATATATG TTTCAAGCAAGAAGTCTACACGTAGGCA

AATATATGTACATATATTTATTTTAGATAC CAACAGATTGAAACTAAATTACACCAGAT

ATGCAAATGAAAGACATATATACAGCCAT ACAAAGGGAGACTATAAAAAAATCCAAAG

CCTTTAGTATCTGTAGGGTATTGGTTCCA ACCAATGACAGGTTACCTACAAAGGAGA

GGACCTCCTGAGGATACTGAGGTGTCTG CAAAATTTTCTGACAGCTGACTGCTCCAC

ATATAAAATGGCACAGTATTGGTCAGGCA AGAAATCATTATAGCCAATAAATATTGGA

CAGTAGATCACACCTGTAATCCCAGCAC ACAATAAATGTAAGGTCCTCAGCTCTTGG

TTTCGGAGGCCAAGGCAGGAGGGTCACT ACAACACAGCCCAACCTTGAAGACCATTT

CGAGCCCAGGAGTTCAAGACCAGCCTG AGGACTGAAAGGCATGGCTGGCAAAGGA

GGCAACATGAGACCCCATCTGTACAAAA CCTACAGCCCTGTAATAGTGACAATT

AATTAAAAAATTAGCTAGGCACAGTGGTG 4--

AGTGCCTGTGGTCCCAGCTACTTGGGAG Se

GCTGAGGCAGGAGGCTCATTTGAGCCTA GGAGTTAGAGACTACACTGAGTTATGAC CATGCTACTGCACTGCAGCCTAAGCAAC AGAGCAAGACTGTCTCTAATAAAATAAAA TAAAATGGAATAGTACTTGCAGATTTGCA TGTAACCCATGCACATCCTCCCATATACA TTTCTG I I M I I I GAAATGGAGACTCACT CTCTTTCCCAGGCTGGGGTGCAGTGGCA TAATCTCAGCTCACTGCAACCTCCGCCT CCCAGGAGCAGGCAATTCTTCTGCCCCA GCCTCCCAAGTAGCTAGGACTACAGGCA TGTGACACTACGCCTGGCTAA I I I I I I TT

I I I I I I I I I I IGAGACGGAGTTTTGCTCCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2014187 19 57167895 TTTTTCAAGTATAGCTATAAACTGATGGA CfT TAAATATAGACAAGGTCTCACTAGATTGC SEQ_0747

ATTTTATATAATTAATGTTCTTCAATCATTT CCAGGCTAGTCTCAAACTCCTGGGCTCA

GCAATCATTGGTCTTTGGATGTTCAAAGT AGGAATCCTCCTGCCTAAGCCTCCCAAA

GTAGCATCTTCGGCCAATGAAGAGTCCC GTAGGCATAAGCCACTGCACTCAGCCAG

TTCAAGTTGGCTGCTATGTTCTTTGAAAT AAAC I I I I I I I I I I I I I I I I I I I GAGATGG

ATGATTCTATCATGTAAAATATATATATGT AGTCTCTCTGTCACCCAGGCTGGAGTGC

GTATATCATAATGAATATATATATCTACAG AGTGGCACCATTTCGGCTCACTGCAATTT

ATAGATTCATATATACTCACACTTTTATTA CCGTCTCCTGGGTTCACGCCATTCTCCT

ATACATATATAGACATAGATCCACAAACA GCCTCAGCCTCCCGAGTAGCTGGGACTA

GATACAGTGACAGGAAGTAAATATTACCA CAGGCACCTGCCACCACACCCGACCAAT

ACCATTTACAGAAGTGGATTAGGAAGAAA I I I l I GTA I I I I I AGTAGAGACAGGGTTT

ATATGTGAAMGAAAACTTTTTCTCTTTTC CACGGTGTGAGCCAGGATGGTCTCGATC

TTCAATTTTA TCCAGACCTCGTGATCCACCCACCTCGG

TCTCCCAAAGTGCTGGATTACAGCCATG

AGCCACCGCGCCCAGCCGAAATTTATTT

TTTGATATGTGTACTTTCTTACTTTACTGG

GACACAATCACAGATGACCTATGTGGCT

GATCTTAGGTCCACACCCTCCCAGAAGT J-.

CAGGTTTTAACTTTAGCCTCTAGTTCTGG ^O

AAGTTTCTGGCCTATCATAGATCACAGAT

CTATCATAGTTCGTAI I I I IAGGCTGTCC

AGTGGCCAAAGGACCCAAGCAAACAAAG

ACACTACCATTAGCAAGATATTCCAGAAG

CCCAGAGCTCACCCTCCATTAGCTTGAA

CACAAAGGCCAAAACTCCCTTTGTTCAAT

TATTTACTATACAATAAGGACTTGGCATT

TTCTACAAGGTGAAAGTCTAAAGGAAATC

TGTAAACTCCAATCCAAGTCCTGTTCAGA

CAATATCACTTTCAACTCCCTGTCTCCAA

ATCTATATTCAAACACCAGTTCAGCTATC

TGTTCATTGAGAACCATTTGAAAGTCCTG

GAATCCTGCCATATTCCCAGGATGTCTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 11668463 19 57169792 ATCAAGTGTGCCCCAAGAAATGGTGAAC C/G CTCTGTGACGTTTCCGTGGAAGGACTGT SEQ_0748 CCCAAATCCACTTCCTCCCTCTTCAGGTT GAAGGCAGGTAGGAAATGAGACCCACCA ATGTTTTTTGCTCCTGAGGAGTCAGAACC TAGCACCAGCCTCAGGAGATGGTGAACT TGTGGGTTGAAGAGCAAATTCAATGTAA CTTAGGCAGATTAGTTTTAGAAAAGAGAC GTGGTACATTTTTTCCAGGCCCAGATACT AATCAGCAAGGAGAGGACCTGGTCTTTG GTCACTGCTGCTAGGCACTCATCTTAAA TTTTCCTTTAAATCATGTGTGCTCCCACA GCAATGCCCCCAATATAGTTAACTATATA CCTCTTCAAAAGTCTTTGTACATACACCC CCTTTGTTTGGAGCCCCAGCGGATTTTAT TGTGAAGACATGTACTTCAGTTTGAAAGC ACCTGTGGCCAATAATGTCTAGGATTCTT CAATGTACTGGGCAAATCATAAGCATTGT AATGTGGTGGAGGTATGCCTTT CATAAAAACAGTACTGACAATATTTTAGG AGGTTTTAAATACATAAAAAGCTAAAATA CACAATAATTTACTGGATAATTAGGTGGT GAATAAAGTTGACGTGCTCTAAGGTTTCT GTAGAATGGAAAAGTGCCAATTAGCAGA AGAATATGACAAAGGTTGCACACTACATG TAA rs11671547 19 57177705 TGCTATGTAGGCTCTAGACTAACTCACAC C/T AATCCCAAACTGATACTGAAAAGTTTAAA SEQ_0749 TGAGTAGCCATAAAATGCCATTCACTGGA TAGCTATAAAC I I I I I I I IAAAGTTTGAAA CATCCTAACTCATAAAACCCCATAGTTAA AAAAAGTTAGAAGACTTGCCATATCAGTT

O CAATGTACAGCCAATTGTTAATTGATATT ATGAGGACTTATAAAGCTACTTTAATTAG ATTTCTGTAAACCAATGAGAATTCTTGCC GACAGCACAATATTAGTACAATAACAGGC AAACAACTTTATGTCAGCTCACGGTTTGT AAATAGGACAAAGGAACAGAATAAAATCC TCCCTTTTGACTTTAAAACCTGTTTCTAAC TTATAAGCAGAATTAAGCACATATAGAGA AAAATCCTAACAGAGCACTTAACCAAGG CTCAATGGCAATGATAGCACTACAGGGA CAACCTGAAAGTATTTTCCCAGGCAGCT AGTAGATAAAAGCTGTCTTTTCAATAAAT GTCCTCATTTTGGCTCAAGTAAACTCTTT GGAACTAAGGGCGCCGTGGCTCACGCC AAAATTGTATTTTGTGCAGTTTCCTCTTTT TGTAATCCTAGCACTTTGGGAAGCTGAG AGGCTGACATAAACGATATCATTTAGAAG GAAGGTGTGGGGGAAAGAGAGATCAGA AACTCGAATATA I I IT I AAAATTAGATTTA CTGTTACTGTGTCTATATAGAAAGAGGAA CTGAGATAAATTTTAACAGTTTTAAATAAA GACATAAGAAACTCCATTTTAATCTGTAC TGCAAAGATGTACTATAAAGATGGGCTG AAAGAAAAGTTCCTCTGTCTTGAGATACT GAAAACAAAGCATTTTAAAAATGTCAAGT GTTAATCTGTAACCCTAGCCCCAACCCT CTCCCAAATCTACAGATTCAATGAAATCA GTGCTCAGAAACGTGTGCTGTGTTGGCT CAGTCA CAAGGTTTAATGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11671769 19 57178115 CAAAGATGTACTATAAAGATGGGCTGGA A/G TTCCTCTGTCTTGAGATACTGTTAATCTG SEQ 0750

AAACAAAGCATTTTAAAMTGTCAAGTCT TAACCCTAGCCCCAACCCTGTGCTCAGA CCCAAATCTACAGATTCAATGAAATCACA AACGTGTGCTGTGTTGGCTCAAGGTTTA GTCACAATCCCAAACTGATACTGAAAAGT ATGGATTTAGGGCTGTGCAGGACGTGCT TTAAATAGCTATAAAC I I M I I I I AAAGTT TTGTTAAAATGTGTTTGCAGGCAGTATGC TGAAAAAAAAGTTAGAAGACTTGCCATAT TTGGTAAAAGTCATCACCATTCTCCAGTC CAGTTATGAGGACTTATAAAGCTACTTTA TCAAGTACCCAGGGACACAATGCACTGC ATTAGGACAGCACAATATTAGTACAATAA GGAAGGCCGCAGGGACCTCTGCCCAAG CAGGCAAATAGGACAAAGGAACAGAATA AAAGCCTGGGTATTGTCCAAGGTTTCCT AAATCCTTATAAGCAGAATTAAGCACATA CCCACTGATACAGCCTGAGATATGGTCT - TAGAGACTCAATGGCAATGATAGCACTA CGTGGGAAGGGAAAAACCTGACCATCTC CAGGGAAGTAGATAAAAGCTGTCTTTTCA CCAGCCCAACACTCGTAAAGGGTCTGTG ATAAATGGAACTAAGGGCGCCGTGGCTC CTGAGGAGGATTAGTGAAAGAGGAAGAC ACGCCTGTAATCCTAGCACTTTGGGAAG CTCTTTACAGTTAAAATAAGAGAAAGCCA CTGAGGAAGGTGTGGGGGAAAGAGAGA TCTGTCTCCTGCTCCTCCCTGGGAATGG TCAGACTGTTACTGTGTCTATATAGAAAG AATGTCCCGGTATAAAACCCAATCATACA AGGAAGACATAAGAAACTCCATTTTAATC TTCTATTTACTAAGATAGGAGAAAACCAC TGTACAAAGAAAA CTTATAACTAAAGGTGAGA 4-

00

ΓS8102072 19 57180523 ATAGGCAAAACTGTATTAACTACAATGAT C/T GCTCCCTCAGAAACTCCCAGGCAGATTT SEQ_0751

AAATAATGATTAATTATATAAAGAAAAGC TCACATACATAGTTGGCTAGAATTGCACC CTAAAATACTTTTCGGTGTGAGAATGGAA ATACGCCTAAGCTCATTTCCATGTCAAAC AAAGACTCACAGAACACCACTGGTGTGC CTATCACTAGCAATGGCAATTGGAACCA TGACCATATTCTATTTCTTGACCTGGGCA GCAAGATTGGCTAAGACCAACAAGGCCT ATGACTGCTTATACATATATTGCCTCCAT TACTAAGAAACTGGGATTTGGGTCGCCT GATAATTAAATTGTACATTTAAAATATATA TGCCACAGGGATGAATACTTCACGAAAT AATGTAGAAAAATTAACAAAGTAAAGGAA GGAGATTCTGTTAAGAAAGTGTGAATATA GAGATCAACCATACCAAACAGTTTACCTC AGGCGGGCAAGCAACACTCACTATATAT CAGGAAAGGTGTTAACTCCAGACAACAC TAAGAAGTGAAGGCCGGGCGCGGTGGC AACGGGTGAATTTTACAGGTGGGTAATA TCACGCCTGTAATCCCAGCACTTTGGAA AAACAAGAACGTCCACTAACACCCTATTT AGCCAAGGTGGGCGGATCACCTGAGGT TCCTACTTTATACTGGAAAGTTGAGCCAA CAGGAGTTCGAGACCAACCTGCCCAACG

TGCATTAAGATAAGAATGAATTATAAGCA TGGTAAAACCCTGTCTCTACTAAAAATAC TTACAAAGTAAGACAGAAAATTAATGTTA AAAAACTAGCCGGGCGTGGTGGCGTGG TΠTCAGGCGATATCATCACGAACATGGA GCCTGTAGTCCCAGCTACTCAGGAGGCT AAAAGAGATTCAAGAAATTACATATTTAA GAGGCAGGAGAATCGCTTGAACCCGGG

AAAAGAAAA AGGCGGAGATTGCAGTGAGCCGAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Ranking Sequence SEQ ID rs11084127 19 57187192 GCTGAGGAGAGGTTGTGACTATAAACAA CfT AAAGAAATGCAGGAGCTAATCATATAATA SEQ_0752

GGAGCATGAGGGAGTTTGCATTGATGCA AAATGAGGCAGGCATAAAATACTCCGGT ACATTCTGAATCTCGATTACGGTGGTGGT ATTATATACAATATTAAATTTTAGTTCGTG GACATGAATCAATATATGTGTTAAGATTT ATTAGAGGAAGTCACAATTTAAAATGTAT CTTAAAGCTACATATAAAAAACAAACAAA AAAATCAGTGACAAGGCAACTAGGAATAT AATGCATGCATGTTAAAACTGGTGATTTC GGCTCAAGCTATCCTGTTCCCAAATGCA CAAATAAATTCTGTAGTTAACAGTATTGT CATGAGGCATATTATCTGTTAAGGTTA AACAATTTCACTTTCCTGTATTTGGTAAT GAACTATGCTTATGTAAGTTGTTATCTTT GGAAGAAGCTGGGTTAAGGGCAAGAACT CTGGAATATTTTGGTAAGATTTTGTGAAT CTAAACTTATTTCAAAATAAAAACTTACAA AAACATCTTATrTATATTAATTTCATAACA CCTGATGTTACTTATAAACTTAAACATATT CAAGTATGGTCAATTACACTTATGAACTG AATATACTGTATCCAGTTTCATTCTGAAG TACTTTAGTTATTCTGAAATAACACAAACT TAGAAC rs 1 1084128 19 57187458 CAATATTAAATTTTAGTTCGTGATTAGAG A/T TATTTTCCTAAAAGTCTTCTACATTGAATG SEQ_0753 so

GAAGTCACAATTTAAAATGTATAAAATCA TTTTCATAAG I I I I Π CTGCATTATTTCCT 1» GTGACAAGGCAACTAGGAATATGGCTCA AGCACACGATGAGGCAAAACATTTTACT AGCTATCCTGTTCCCAAATGCACATGAG GAAAACCCTGCCACAGGGGTTTGCCAGA GCATATTATCTGTTAAGGTTAGAATTGTG GGAAAGTATTTCTCCAGTGTGAACTCTCT ACAGAAAGCTCTCATCCATCATTTTGCCA CAATCTGTTGAAGTTTTATTTTTGGGCAA AGGCTTCTTTCCTTCATTAAATTCTCTG AGACGTTCCTATAATTATTACATTTC rs2288887 19 57187615 TCCATCATTTTGCCAAGGCTTCTTTCCTT A/G GTTTTA I I I I I GGGCAAAGACGTTCCTAT SEQ_0754

CATTAAATTCTCTGATATTTTCCTAAAAGT AATTATTACATTTCCACGAATTAGTAGTTT

CTTCTACATTGAATGTTTTCATAAGTΠTT ATTCATGATCTATGATCACTTCTGAGGGG

TCTGCATTATTTCCTAGCACACGATGAGG GTTTATCTTCCCACCAAAGGCTTTTATAG

CAAAACATTTTACTGAAAACCCTGCCACA TCTGCCACATTCATAGGA I I I I I CTCAGT

GGGGTTTGCCAGAGGAAAGTATTTCTCC ATACAATTTTTAGACATAATGTCCTAAAAT

AGTGTGAACTCTCTCAATCTGTTGA ATTTTCTCAAATGTΠTGTACATG rs16983353 19 57187961 ACCATGTAGTCTGCATTCATGAAATTACT CfT TGTGTTTAACAAGGATAGACAAGTGCGC SEQ_0755

CTTCTTTGCAGATATCTTAAGGGCCTACA AAAAGCTTTCCCACAATCACTACATCCAT TCTGGCAAGAGGCTTTCCCAAAATGACT AGGGCCTCTCTCCTGTATGTTTTCTTTGA ACCTGTGAATTCTC TGAACATTGAGCCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1978717 19 57189062 TGGGAAAGCCTTCATCAAGAAGTGTCGG CfT TGCACATCATCGAACTCATACTGGTGAG SEQJ3756

CTCATTTATCATCAACGAACTCATACAGG AAACCCTTTATATGCAATAAATGTGGGAA AGAGAAACCCCATGGATGCAGTGTATGT AGGCTTCACCTTGAA GGGAAGGCCTTCTCTACAAAGTTCAGTC TCACTACACATCAGAAAACTCATACAGGA GAAAAACCTTATATATGTAGTGAATGTGG AAAAGGCTTCATTGAGAAGAGGCGTCTT A rs 10500311 19 57189755 TCTGTTGCTTAATGAACTGGGACTTATTA A/G TATCACAATCTTGCTTCAGCAGGAAATGA SEQ_0757

ATAGGTTTTGCAATTGCAGGAAACTTCAT CCTTTGTTCTGATTAACAATATTTCCAAAC TTCAGTATAAAATTGTTTATGGTTAGCAT ATATTCTGTTCATGGCACTGTTTCACACT GAAAAAGGGATTTCCCATCTCTATTAAAC CTTCTGAATACTTTGATTTTGCAAGTGAT TCAGCAGAGTTCTTTAGGCCAGAGCTCC GCTGCAGAGGATCATCAATTTTCCTGATT TTTTCTGGTTTTCAAAACTTAAATTTGATT TCTAGGAAAGAAGAGAACAGTCAATCAC TTAAAGG I I I I I CATGTAAGTCAAAC TCCATCATCTTGTTTTGAAATAAACT rs 1836002 19 57190334 TGAGCATAGTGACTTACACATAGATGTCA A/C GGTGTGTTTATATTATTGTGTTTTATTTGT SEQ_0758

TTCAGCAAACATTTGTAGAATAAATTAATA AAGAAATGAAGGATATTTATACATGGAAT CAGCCTTTGTCATTTGGGATCAACCTGTG TTCCTTTATGTGTAAGAGATAAAAGGAAT TGGTCTGATATTTCTCTTTATTTCTGTGGT CTTACACATCTCTCCCAATGTGTAAGAGA CTGGTATCCTGCCAAATTTTGGGGTTCC TGAGGGATATTTATACATGGAGTTTCCTT CTGCAAAAAGTGACCTGTTTATATTTGAC TATACTAAAATAGGGTTTTCAACCCCCTT TATGTGTGTATTGTATAMGACCTATTTA TAGCTGTAATTTTCCACTACCTACCCAAA GAAAGCAGCCAAATCTATATACATTGTGA TGCTATAAAACTGCCCTCCCCTTATCACC ATTATCTAGCCTTGTTTGTACAGTTGCTT CTTTTCTGACTCC ! I I I I CGGACTCAGTC TTACTTTT CGCCTGCACCCAGGTGATTAAAAAGCTT TATTGCTCACAAAAAAATAAATAAATAAAA TAGGGTTTTCACTAAAGAGTCACCTCACA CCAAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs8109926 19 57191573 GTGGAGAAAATCAAGATATAGTTAAAGAA CfT TTGTGAAACACATAAAGTTTAAGACCATT SEQ_0759

ATGACAAGGTTCACTAATAGGTTCAATGG ACCACATATCCAAGTACAAACATGAAGAA

GACGAGTGAAAGAGGGTTAATGGAAGTG ATTGGTTGAATATATAAATCTCGAAAAGG

AGGACTCAAAGATTATTCCAAAAATTATA CCTTATCTGGAAACAGCAATGTAGATGAC

TGGTTTCAGGCTGGATACAGTGGCTCAC ATCCAACATTTACAAATTATTCAAAGAAA

ACCTGTAGTCCCAGCACTTTGGGAGGAC GAGTACTGGATGAGACTTTAGTTGGAM

AAAGCGGGTAGATCACATGAGGCCAGGA CATGTAGAAAAAAAGAATGAAGGCACAG

GTTCAAGACCAGCCTGGCCAACATAGTG GGCCAGGGATCTTGTCAATCCAACATGT

AAACTGTGTCTCTACTAAAAATACAAAAA AGAGTTTGGGAATTCGTTAAGTCCACTGA

TTAGGCATGGTGGCACATGCCCGTAGTC AATGAACCATACGCTGACTATTATGATCA

CCGGCTACTTGGGAGGCTGAGGCACAA GGTGCACAAGTGGAGACCCAGGTGTACA

GAATCGCTTGAACCCAGGAGGTGGAGGT AAACAAACATCTAGGAGTGGTAAGAATGT

TGCAGTGGGCTGAAATCACACCACTGCA AATAGCCTCTTGAAAATTGCTAAAATAGA

CTCCAGCTGGGGTGACACAGCAAGACTC TTTTAAGTGTTCTCACAAAAAAAGTAAGT

TGTCTCAAAAAAAAAAAAAAAAAAAAAAA ACGTGAGGTAGTATATACATTAATTTGTT

CGCAAAACTATATGGCTTCAGCCATTGG CAATTTAGCCATTCCACAATGTACACATA

ATAGGAAGAAAAAACCTCATGATGAAAAT TTTCAAAACAACATGTTTTACATGATAAAT

AGGAATATTACTATCTGGAATGAAGGGAA ATATGTA I I I I I I ATTTAGGAATTAAAAAG

AAATTTAGCATGC TAATCATGTCCTGGTGTGGTGGTTCATGT oe

CTGTAATCCCAGCACTTTGGTAGGGTGA ⁴^

GGCAAAGAGGATCACTTGAGCCCAGAAA

TTTGAGACCAGCCTGGGCAACATAGTGA

GACCTTTCTCTATAAAAAATACAGAAATT

AGCTGGGTGTGGTGGCATGTAGTCCCAG

CTAGGCTAAAGTGGGAGGATCACTTGAG

CCCAGGAGATTGAGGCTGCAGTGAGCCA

TGATTGTGCCACTGCACTCCAGCCTGGG

TAACAGAGTAGAAAAATAAAGAAAAGAAA

TCATAAATTTAAAAAACAGAAGAATGTGA

GATCCTCAGCATTTGATTTAAAGTGTCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs8103027 19 57192954 ATTCTATGTACCACCATTAAACTAATTTTC C/T AGCACTTTGTGCAACTCCACTAGAACAG SEQ_0760

CCAAAGCACAATCTCAAGTTTAGATGAAA GAGAACTGAAAGCTTGCACCCAGTTTCT GGTTCTATACTTAAGACTCCAACTAATGA CCTGGATTCTTCTTTCTATAC I I I I I ATCT CCTAACTGGATCATACTATCCCGTGTTGC TTGATGATTTTAATTTGTATTATTTCACTG TACAGAAAGAGGGAACAATGATTTGCAG TCACAAACTGTAATCATGAGTGTAGCAGT CAAAGTGTTAACTCAGCAGGCCTGGGCT TCCCTCTCCTCCCCATTAACGTCTACCTT ATTCCATCCCTACACATTCCAAAGAAAGA CTACGTAGCAGGCAAAGTAATCTATCAAA ACTCGTCTTAACTGCCTTCTAAAAGATAA TAAATTAGTTATATCATGTCACTTCTCTAC CCTCTGAGCCCCTGGAATATTCTGCCTG TCAAAACTCCCTACTGTGTTCTCAACTCA CTAAGGGTATCTTTTAATGCCTGAGGCCT TTTGGAATAAAATCAAGGTCATGAATGCC TGGGTCATATCAGATAGTTTATGCTAGCA CTTGACAGGCAGTATGTGACCTCTGTAC ATGTGATTTATGGTGGACACCTGGTTTTG CAAAACTTCCAACTATGCCCCCACTGTTC CATGTCTCAGGCTTTGGGCCACATTTGTA TTATTTCCAGACAGTTTTGCTTTTGCTCA TTGTTTTGACTCTGGGTGGCTACAGACA CTCTACTCTATCCATTCAAGCTTCCTAGA CTGGGCTTAGATGAGCTTCCCTAGTTGG AGTTCCTCAAACACACTCCAGGGTCATTT CAATAACTTCACATGTGTTGACAAACACT TTCAACTTCTCATTGTCTCACACCTGGAA GTTGCAGGGAAAATT CACTCTTCATCCAGGGAGCCTACACGTG TTCATCATCTATCTGCTCAAAGGCACCTT AACAAAGAGCTGTTCCCACCCTACAAGC ACAGTGCCAACTCCTAACACTTACTGTTC CACCAGCTGCTTTAACTTTCCTTATAGCA A I I I I IACTCCAAGATATGTTATTTATATA TCTGCTTATTACTGGTTATATGGTTACTT CTAAGAGAACAAAAGCATTGTGAAGAATA AGGACATGGTATG I I I I I I CTTTCTTATTT GTACTGCTGATAGCGTTGGAATATAGTA GGCTATCAAAACACAAGTTTTGGGTGTGT GGTGGAGGCAGGGGGGTTTGTCATCCA GCCTGGAGTGCAGTGGCATGAACTTGGC TCATTGCAATGTCTGCCTCCAGGGTTCA GGCGATTCTCCCACCTCAGCCTCCTGAG TAGCTGGGATTATAGGCACATACCACCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs8103812 19 57193444 CCACCATTAAACTAATTTTCCCAAAGCAC A/G TGTTCATCATCTATCTGCTCAAAGGCACC SEQ_0761

AATCTCAAGTTTAGATGAAAGGTTCTATA TTAACAAAGAGCTGTTCCCACCCTACAAG

CTTAAGACTCCAACTAATGACCTAACTGG CACAGTGCCAACTCCTAACACTTACTGTT

ATCATACTATCCCGTGTTGCTACAGAAAG CCACCAGCTGCTTTAACTTTCCTTATAGC

AGGGAACAATGATTTGCAGCAAAGTGTT AAI I I I IACTCCAAGATATGTTATTTATAT

AACTCAGCAGGCCTGGGCTATTCCATCC ATCTGCTTATTACTGGTTATATGGTTACTT

CTACACATTCCAAAGAAAGAACTCGTCTT CTAAGAGAACAAAAGCATTGTGAAGAATA

AACTGCCTTCTAAAAGATAACCTCTGAGC AGGACATGGTATG I I I I I I CTTTCTTATTT

CCCTGGAATATTCTGCCTGCTAAGGGTA GTACTGCTGATAGCGTTGGAATATAGTA

TCTTTTAATGCCTGAGGCCTTGGGTCATA GGCTATCAAAACACAAGTTTTGGGTGTGT

TCAGATAGTTTATGCTAGCAATGTGATTT GGTGGAGGCAGGGGGGTTTGTCATCCA

ATGGTGGACACCTGGTTTTGCATGTCTC GCCTGGAGTGCAGTGGCATGAACTTGGC

AGGCTTTGGGCCACATTTGTATTGTTTTG TCATTGCAATGTCTGCCTCCAGGGTTCA

ACTCTGGGTGGCTACAGACACTGGGCTT GGCGATTCTCCCACCTCAGCCTCCTGAG

AGATGAGCTTCCCTAGTTGGCAATAACTT TAGCTGGGATTATAGGCACATACCACCA

CACATGTGTTGACAAACACTGTTGCAGG CACCCGGCTAATTTTTGTATTTTTAGTAG

GAAAATTCAGCACTTTGTGCAACTCCACT AAACGGGGTTTCACCATGTTGGCCAGGC

AGAACAGGAGAACTGAAAGCTTGCACCC TGGTCTCGAACTCCTGAACTCAAGTGAT

AGTTTCTCCTGGATTCTTCTTTCTATACTT CCATCTGCCTTGGCCTCCCAAMTGCTG ∞

TTTATCTTTGATGATTTTAATTTGTATTATT GGATTACAGGCATGAGCCACCGCGCCCA ^

TCACTGTCACAAACTGTAATCATGAGTGT GCCCAAAACACAAGTTTTAAAGGAAGGA

AGCAGTTCCCTCTCCTCCCCATTAACGTC ATCATATGACAAGAAACATGATTAACTGG

TACCTTCTACGTAGCAGGCAAAGTAATCT GACTAGGTGTCATCAAAATATGATAGAAA

ATCAAATAAATTAGTTATATCATGTCACTT AGTAATTAATGTTATTTCTATATTCTAGCA

CTCTACTCAAAACTCCCTACTGTGTTCTC ATGAATAATCTGAAAATGTAATCAAGAAA

AACTCATTTGGAATAAAATCAAGGTCATG ACAATTCCATTAACTGCAGAAACAAAAAG

AATGCCCTTGACAGGCAGTATGTGACCT AAAACTATACTTAGGAATATACTTAGCAA

CTGTACCAAAACTTCCAACTATGCCCCCA AGGAAGTACCAAATTTATATTCTGAAAGT

CTGTTCTTATTTCCAGACAGTTTTGCTTTT GATAATGCATTGTCGAAAGAAGTCAAAGA

GCTCACTCTACTCTATCCATTCAAGCTTC CCTAACAGGATATAAAACTGTCCAGTGTT

CTAGAAGTTCCTCAAACACACTCCAGGG CATGGATCAGAATACTTAATATGATGAAA

TCA I I I I ! CAACTTCTCATTGTCTCACACC ATGGGAATACTCCCCAAAATTGTTACACA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7247405 19 57194524 CAATGATTTGCAGCAAAGTGTTAACTCAG C/T TACTATAGAACCATAATCATCAAGACTAT SEQ_0762

CAGGCCTGGGCTATTCCATCCCTACACA TTGATAATATATATTTATACATAGTATATG

TTCCAAAGAAAGAACTCGTCTTAACTGCC TTCCAAAATTGATTGTGGTATGGTTACAC

TTCTAAAAGATAACCTCTGAGCCCCTGGA AACTAGGTGAATAGATTAAAAACCACTGG

ATATTCTGCCTGCTAAGGGTATCTTTTAA CTTATACACCTTAAATGGGTGAAATCATG

TGCCTGAGGCCTTGGGTCATATCAGATA TGATATGTGCATTGTATCTCAATAATAGT

GTTTATGCTAGCAATGTGATTTATGGTGG TTACAAATATGATGAAAAAAGCAAAAGCT

ACACCTGGTTTTGCATGTCTCAGGCTTTG ATACAGAAATGAATGCAGTCAAAACATCT

GGCCACATTTGTATTGTTTTGACTCTGGG AACATGAATTAAAGAAAGTTCAGAATTAG

TGGCTACAGACACTGGGCTTAGATGAGC CAAAACTATGAAGGAAGTAATTTGCAGCA

TTCCCTAGTTGGCAATAACTTCACATGTG GGCATAAATGTCTGATGGTTTGGGCTAG

TTGACAAACACTGTTGCAGGGAAAATTCA AMTAATATACGATATTAAAAGATCTTTTC

GCACTTTGTGCAACTCCACTAGAACAGG T

AGAACTGAAAGCTTGCACCCAGTTTCTC

CTGGATTCTTCTTTCTATAC I TV I I ATCTT

TGATGATTTTAATTTGTATTATTTCACTGT

CACAAACTGTAATCATGAGTGTAGCAGTT

CCCTCTCCTCCCCATTAACGTCTACCTTC

TACGTAGCAGGCAAAGTAATCTATCAAAT oe

AAATTAGTTATATCATGTCACTTCTCTACT ^"^

CAAAACTCCCTACTGTGTTCTCAACTCAT

TTGGAATAAAATCAAGGTCATGAATGCCC

TTGACAGGCAGTATGTGACCTCTGTACC

AAAACTTCCAACTATGCCCCCACTGTTCT

TATTTCCAGACAGTTTTGCTTTTGCTCAC

TCTACTCTATCCATTCAAGCTTCCTAGAA

GTTCCTCAAACACACTCCAGGGTCATTTT

TCAACTTCTCATTGTCTCACACCTGGAAC

ACTCTTCATCCAGGGAGCCTACACGTGT

TCATCATCTATCTGCTCAAAGGCACCTTA

ACAAAGAGCTGTTCCCACCCTACAAGCA

CAGTGCCAACTCCTAACACTTACTGTTCC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1 1084129 19 57196302 GAGTGGAGAAAATGAGGGAAAATAATGA A/G AGAAAAGGCAGATTTGAAAATCCTAAGAA SEQ_0763

TTCCCAGAGTGGGAATAATGAAGGAAAA GATAATTATGTAGACAAAAACAAGATGTG

TTATTATTTTCCTACTAGGGCAGGAAGAT CATAAAATAAACAAAGATGAAATCTCAAG

GCAGTAGTCAGAAAAAAGTAATGAGTTCA GAAAAAAAGTGGGGGCCGGGCGCAGTG

AAGGTCTCTCTTTCCGGAGAGGCCTGGA GCTCAAGCCTGTAATCTCAGCACTTTGG

AAATGGAATTTCATAGCAAGAGAGGTAAT GAGGCCAAGGTGGGCAGATCACAAGGT

ACACAAGCAGAGACACTGTGACAGTGGA CAAGAGATCAAGACCATCCTGGCCAATA

C TGGTGAAACCCCGTTTCTACTAAAAATAC

AAAAATTAGCTGGGCGTGGTGGTACGCA CCTGTAGTCCCAGCTACTCAGGAGGCTG AGGCAGGAGAATCCCTTGAACCCGGGA GGCGGAGGTTGCAGTGAGCCAAGATTG CGCTACTGCTCTCCAGCCTGGTGACAGA GCAAGACTCCATCTCAAAAAAAAAAAAAA AAAAAGAAAAGAAAGTGGGGCATATTTTC CATACTATAACAAAAAAGAGCTCTTCCTT GGGAAGAAGGAGTGATGGAGGGGCTGT TGCTGTGTCCTCAGATGCCCTC

06 so rs2903709 19 57196732 AAGCAGAGACACTGTGACAGTGGACAAG C/T AACAAAAAAGAGCTCTTCCTTGGGAAGA SEQ_0764

AAAAGGCAGATTTGAAAATCCTAAGAAGA AGGAGTGATGGAGGGGCTGTTGCTGTGT TAATTATGTAGACAAAAACAAGATGTGCA CCTCAGATGCCCTCACTGCTTTGACGCC TAAAATAAACAAAGATGAAATCTCAAGGA TGCTCTGTGTGGGCAGAACATGGTGTCT AAAAAAGTGGGGGCCGGGCGCAGTGGC GTGGCTGTCCACCTGGCTGCTCCTCTCA TCAAGCCTGTAATCTCAGCACTTTGGGA CTCACCAGAACAGATTCGAGAGTAGATTT GGCCAAGGTGGGCAGATCACAAGGTCAA CATCTTCTGTTGTGCAAGTTTCTTCTCCT GAGATCAAGACCATCCTGGCCAATATGG CGTTCCAATTTGGAGAGTGCATCTGGTTT TGAAACCCCGTTTCTACTAAAAATACAAA GCTGGCTTGATACCCTGTTCATGGGAAA AATTAGCTGGGCGTGGTGGTACGCACCT TGACAGAAGATTTAGACAAATCAAACGG GTAGTCCCAGCTACTCAGGAGGCTGAGG GGCTGGCAATATTGAAAAAGGAGAGTTA CAGGAGAATCCCTTGAACCCGGGAGGC CATTTTAAGGACTACATAGGTATCAGATC GGAGGTTGCAGTGAGCCAAGATTGCGCT TGTAACAAGAAGGTAGATTATACTCTCTT ACTGCTCTCCAGCCTGGTGACAGAGCAA GTGTGGGGCAAGAGAATGATGTGAGAAT GACTCCATCTCAAAAAAAAAAAAAAAAAA CTACCACTTCAGAGTACTGCAGG AGAAAAGAAAGTGGGGCATATTTTCCATA CTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2903710 19 57199350 AATCTCCAATCAAGGATGTCCCCAGAAAT C/T TACATTCTAGGATACTGCAATCTGAGAAC SEQ_0765

GATGACACCCAAGTCTTGGAAACTCCGC ACTGTCCTAAGCAAATAATAAGCACTATC

CTCCTTCCTTCACTTGATTTCTCTTGTTCT TTATTTAAATTATTCATTACCATCCACATC

CAGCACCTGTGGGCTGAAGAGCAAATTA TTTGAC I I I I I I I C I I I I I I I I I I GAGACT

CTCTGAGTGGTACATTC I I I HAGGCCCA GAGTTTCACTCACTCTGTTGCCCAGGCT

GATGTTGTCACTGTTCCTATATGCTCACC GGAGTGAGTAAGACTCCAGTGGCGTGAT

TTAAATCAAGGCCCCCAAATATCTCTCTG CTCTGTTCACTGCAACCTCCATCTCCTGG

TTCTTTTATTTAGTGCTCCAGAAGCTTTTA GTTCAAGCGATTCTCCTGCTTCAGCCGC

TATCTGGGCTAGTAAAATATAACATTCTG CTGAGAAGCTGGGATTACAGGTGAACGC

AATATATGGGAGGTACAGCACCCTTCTAT CACATGCGCTGCTAA I I I I I GTACTTTTA

ATAAAGTTGACGTGGTATGACTACTGCTA GTAGAAACGGGGTTTCACCATGTTGGCC

GTAAGTGAAAGAGAATGTGGGGAAAAGA AGGCTGGTCTTGAACTCCTGAGCTCAAC

ATCGTCACAACGTGATGCCCAGCAGCTG TGATCCACCCATCTCAGCCTCCCAAAGT

GGCAATCCTCAGGCAGACCAGTTTTAGG GCTGGGACTACAGGCATGAGCCACTGCA

AAAGAGGTCACATAGACAGTTAAGATGC CCCGGCCGCCATCCACATCTTGATACTT

ACACATTTTTTCTTTAAAACCATGTGTACC GCAAAGTATTCTAAGTATAAATGTATAAA

CATCTACCTΠTCAGAGGTCTTT GGATACTCAGCAAAAATATCCTTGAGGAA

TTACATATTACAGC RS8109948 19 57199861 AGAATCGTCACAACGTGATGCCCAGCAG A/G GATATTCTTCAAGCAAAAGAAAGATGACT SEQ_0766 £

CTGGGCAATCCTCAGGCAGACCAGTTTT CCAGTGTAAGCAGAGGAGCAAGGTCTGA "°

AGGAAAGAGGTCACATAGACAGTTAAGA AGAGGAACAAAACGGTAAGTAATTAATAA

TGCACACA I I I I I I CTTTAAAAC CATGTGT AGCCTAAATCAGTATTGACTGGAAAAATA

ACCCATCTACCTTTTCAGAGGTC I I I I IA ATACTGATAATAATATATCAGGAAGTTTTA

CATTCTAGGATACTGCAATCTGAGAACAC ATATATATAGTGTTAAAATATTCCATAAGA

TGTCCTAAGCAAATAATAAGCACTATCTT ACATATAGGCCGGGTGCGGTGGCTCAC

ATTTAAATTATTCATTACCATCCACATCTT GCCTGTAATCCCAACACTTTGGGAGGCC

TGAC I I I I I I I C I I I I I I I I I I GAGACTGA GAGGTGGGCAGATCACGAGGTCAGGAG

GTTTCACTCACTCTGTTGCCCAGGCTGG TTCGAGATCAGCCTGACCAACATGGTGA

AGTGAGTAAGACTCCAGTGGCGTGATCT AACCCCGTCTCTACTAAAAATACAAAAAT

CTGTTCACTGCAACCTCCATCTCCTGGG TAGCTGGGCATGGTAGCGCGTGCCTATA

TTCAAGCGATTCTCCTGCTTCAGCCGCC ATCCCAGCTACTCAGGAGGCTGAGGCAG

TGAGAAGCTGGGATTACAGGTGAACGCC GAGAATTGCTTGAACCCAGGAAGCGGAG

ACATGCGCTGCTAA I I I I I GTACTTTTAG GGTGCAGTGAGCCAAGATTGTGCCATTG

TAGAAACGGGGTTTCACCATGTTGGCCA CACTCCAGCCTGGGTGACAGAGTGAGAT

GGCTGGTCTTGAACTCCTGAGCTCAACT TCTATCTCAAAACAACAACAACAAAAAAG

GATCCACCCATCTCAGCCTCCCAAAGTG AACATATAAAGTAGGAGGAT

CTGGGACTACAGGCATGAGCCACTGCAC .

CCGGCCGCCATCCACATCTTGATACTTG .

CAAAGTATTCTAAGTATAAATGTATAAAG

GATACTCAGCAAAAATATCCTTGAGGAAT

TACATATTACAGCAAATCCTAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs12461141 19 57200777 GCAAATGAAAACGTATTTTAAGATATCTG A/G GAACACAGCTACATGCATTCCATGACATT SEQ_0767

CATAGCAGAAGAGTATAAAATACTAATTA TCATCTCAGGCTATTATCACATTACAATG CCATAACATTAACAAATAAGTTTATATGTT GCAGAGTTGAGAATTTGGGTCTAGAATG GTTTGTAATCAATAGTGTCAGCAATAAAA TCACTCAGTAGAATGCAGTATAAAAAAAT CTAA I I I I I AAAAAATTATTTCCATGTTAA AATCAAAGATGACTTTTGAATATAAGGGG AAGAGAGGTCTATGGTTTCCGTGGCAGC CAAATTATCAGTATTTGCCTAATACGTCT TACTCAACTCTACTGTTGTAGCTCAAAAA GTATTCCTTTAGTCAGGTGGCTGGATACA TGCCCACATACAAAAAAATAGACAAATGA AAATTTAAATAGAAAAATCCTATATCCTCC TTGTGGCCAGGTCCCAACAAAACTTTATT TAAAGCATATACAGATCGAGTCAGTATTA

AACAGAAACAGGTGCTGGGAGATTTAGT AGAGCAGAACCTTT

CCATGGGCTCTAGTTGCCCAACTGTGAA

TTTGTGCAGAAAAGCCATATGGTCACCTA

AATCAAGAGTCAGTAATATAGTATCCAGG

ACCTGGACCACCTGTΠTGTAAATAAAGT

CTTATA rs 12459079 19 57200806 GCAAATGAAAACGTATTTTAAGATATCTG C/T TCATCTCAGGCTATTATCACATTACAATG S EQ_0768

CATAGCAGAAGAGTATAAAATACTAATTA GCAGAGTTGAGAATTTGGGTCTAGAATG CCATAACATTAACAAATAAGTTTATATGTT TCACTCAGTAGAATGCAGTATAAAAAAAT GTTTGTAATCAATAGTGTCAGCAATAAAA AATCAAAGATGACTTTTGAATATAAGGGG CTAA I I I I IAAAAAATTATTTCCATGTTAA CAAATTATCAGTATTTGCCTAATACGTCT O AAGAGAGGTCTATGGTTTCCGTGGCAGC GTATTCCTTTAGTCAGGTGGCTGGATACA TACTCAACTCTACTGTTGTAGCTCAAAAA AAATTTAAATAGAAAAATCCTATATCCTCC TGCCCACATACAAAAAAATAGACAAATGA TAAAGCATATACAGATCGAGTCAGTATTA TTGTGGCCAGGTCCCAACAAAACTTTATT AGAGCAGAACCTTT AACAGAAACAGGTGCTGGGAGATTTAGT CCATGGGCTCTAGTTGCCCAACTGTGAA TTTGTGCAGAAAAGCCATATGGTCACCTA AATCAAGAGTCAGTAATATAGTATCCAGG ACCTGGACCACCTGTTTTGTAAATAAAGT CTTATAAGAACACAGCTACATGCATTCCA TGACAT rs12461230 19 57201116 AAGGGGCAAATTATCAGTATTTGCCTAAT C/T CCATTCCTAAAACTTTCTTAAAAGGTAAT SEQ 0769

ACGTCTGTATTCCTTTAGTCAGGTGGCTG ATTGGCAAAAGTGTGCTATCTGACAGGT GATACAAAATTTAAATAGAAAAATCCTATA CA I I I I IACTTTCTTCACTTGA I I I I I CAT TCCTCCTAAAGCATATACAGATCGAGTCA AGGGAAAACACAGGTTTACATCAGAAAA GTATTAAGAGCAGAACCTTTCTTGGGAAC ATATTAGCATTCTACATTTAAAATAAAATT AATTTAACATTCTATTGAAAATTGCCAATA GCTGATGGTAGTTCAGTAATATAAGTTTA AAGGTATACCTGGTAACCCAAAAC CGGCTTTAAATGTTTTCATTAATAGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

I-S6509611 19 57202018 ATACAATGTTAATGGTAAAAGCTAGGTGG A/T MGTAATAGTCTAGATTGAAGATTAAAGG SEQ_0770

TAGGCATATTGGTATTAACATTAAACTTC CAGGAAAAACAAAATTCATGGATAAATGG

TTTCAATATTTCCATAGGTTCAAAAATTTT ATAATCATAAAATGTTCCTAAAAATAATAC

CACAAAATAATATGTTAGGCAGAGAGAAA CTAAACATTTTAAAACATTTCACTTCTATC

AATATTGTAATACTAAGAATTAAGATGAC CAAATGTACGCATAAACTTAATGTGAATG

CAAATATAAAATAAATATTTAAAATTAATT CACTTATAGTACCACCGGCTCAAACAGTA

TATCTTTTGTTATAGATTATAAGGAAAGG AAAACAACTTCTAAATGTTTATTA GGAGTCAGAAAGCAATACACTGCAATA rs81 1 1873 19 57209332 AGTCCAAATATGTTGTTAATATATTTAACA OfT AATTCAATTCTGACACTAACTTCTCCAAG SEQ_0771

TATTCAGTTTCTTTTCTACTTAAGTTTGCT TTAGTGCAGACTCCACAAGTTAGTGCAG

TAATGTACAATTAAGCTCAGAGCCAAAGA TCCAAGTTAGTGCAGTGCAAGTTAGTTAG

AAGGAAAAGAGCTAATCATAATATGGGG TGCAGTCTAAATTAGTGCAGACTCCACAA

TGGTTGTTCTGGAGTATTTTCTGACACAA GTTAAGGGGCTCAGTCCAAGACTTCCCC

ATAAATTCTCTAATTCTCCCACACCAATT CACATCAGATGCCACTCACAAGGACAAC

GGGTGTTCTACAATTCAATTCTGAACAAC CTGCAGTTCTGAATGGTGATAAATTCCGA

TGGGTGTTCTA GTTCCCACTGCCCTACTCAGGTTTGATAA

TTTGCTACAGGGCTCACAAAACTCAAGAA

AACAGCGTACTTTGTTTTACTGGTTATAA δ

AGGACGCAMTGAACACTCAAATGAAGA ^

GGTACATAGAGTAAAGCCTAAAAAGGGT

TCTCCTAATCTCAGGAGCCTCTACCCCTA

TGAAGTTGGGGGTGCACCACCCTCTTGG

GCTATTTGGAGTTCTCTTAATCTCATTGT

CTMTCTAATCTCCAGCACCCCTCCCCTT

CCAGGAGGTGGGAGAAATGGGGCACAA

AGTCTCCATCCTCTAGTTACTTGATCTTC

CTAGAGAACAGCCCCATTCTGAGGCTGT

CTAGGGGAGCAACCATAAGTCACTTCAG

TAGTATAATCAGGTGTAATTAAAAGGGCA

GTGCTATGAATAACAACAACAGCAAAAAC

AAAACAAAACCAAAAAACTCTTATCACTC

ATGAAATTCTAAGCGTTTTAGGAGCTCTA

TGCCAGGAACCAGGAACAAAGACCAAAT

GTATTTCTCATTATACCACAATT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base s' Flanking Sequence SEQ ID rs8104890 19 57211420 AGTCTTTCCTGTATGACATCTCTCATGTT en^¬ GAGAGTGCGTTTGACAGTGAAGCCTTTT SEQJD772 GTATGAGGCATATTTTCTGGCTGAAGGC CCACATTCGCTGCATATGTAAGA I I I I I C TTTACCACATTCATTGCATTCATAGGGTT TCCTGTGTGGGAGCGCTGATGTACAATG TTTCTCCTGTATGAGTTCGCTGATGTATA AGATTGCTCTTCACGGTAAAGCCTTTTCC ATAAGAGTGCGCTTTGTGGTGAAGCCTT ACATTCACTGCACATATAGGGTTTCTCTC TACCACATTCATTGCATATGTAAGATTTC CAGTATGAGTTCGCTGATGTACAACAAG TCTCCTGTATGAGTTCGCTGATGTATAA ATAGCGCTTCATGGTGAAGCCTTTTCCAC rs9636139 19 57213108 AAAAAGTCTTTAAAGCTATAACAGCATTA A/G TCCATGGTTCTTGTCCATGTGCCAACTTG SEQ_0773

AAAAAGTTATCAGATGGGGAGATGAATAT GAGAGTACATCTGGTTTGCTAGTTTGATA ATAGTGGAGCTGCTTAGGTACCCTCAGA CCCTGTTCATGAGGAAAGACAAACACAA TACTTCATATATGTGACACCTTTCCTTAAT ACATCCTGAATTGGAGTCCAGTATGTCAA GACTACAATAAGACTCCTATAGCCACTGT GATGGAAAAATAATACATTCGATGAAGAA CCTTGCTGGTTCTCACTTACCTGGACAAT AACAATTTCAAAGTAAGCATTCTGTCTTA TTTTATTCTGAATTTTAGCATCTGTT GAAGAGATTATACCACTTTGGGGTCAG rs12610953 19 57213740 TCCTCCAGGGTCAGTGATTCCTGTAATTA A/G TAGGCAAATGACATCAGGACAAATAAAAC SEQ_0774

CAAAGTCCTATTCAATATGATATAAACTC ATCCCTACATTACCAATGACTTCACAACC CTATTGTTAATATAGAAGTATAAGATAATT AATATAAGGATCTGTCATGAATAGACTTC 4- TTTTAAAAATTTTCACAATACAGCCTGCAT ACATCTTGAATTCATAAAATAGTGCTΠTA K> CTATATTCCTTTCTCAAATATACTTTGGTA AATAAATGTAAGAGAAAAGATGAAACTAT GGAGCAAAATCCTCTATCTATACATTTTA ATCTGTATAAAGCACAAAAGGCCCCTAAA GCGCCTATTTCTAAATATTAAAC GTTGATTAGA I I I I I ATTTA I I I I I I AATTT

TTAAAGAGAGATGGTCTTGCTCTGTAGC

CCCAAATGGAGTGCAGTGTCACAGTAAT

AGCTCAATGCAACCTTGAACTCCTAAGCT

CAAGCGACCTTCCCACCTCAGCCTCTCA

AGTAACTAGGACTACAGGTGGATGCTAC

TACCAA I I I I I GTAGTGACAGGGTCTTGT

TATGTTGACCAGGCTGGTCTTGAAGTCC

TGGCCTCAAGAGATCCTCCTGCCTCGGC

CTTCCAAAGTGCTGGGATTACAGGTGTG

TGCCACTGCGCCCAGCAAAAAAAAACTT

CTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7508453 19 57217930 CTGGATCATCTAGATCATGGAAAATACAC C/G GTGTGGCATCCTCCCAGCACCCTGGTAT SEQ_0775

AATTTGATAACATAGTAAGTGTTGGCAAG GTTCACAAACCTGAAGCTTGTTCAAGAGT

ATTTGCAGCACTGAATGTΓTTTGTGCAGT ACAAAAAATTAGCCGGGTGTGGTGGTGG

GTTTTCCAACACTAACAACCAATTCTCCA GTGCCTGTAGTCCCAGCTACTCAGGAGG

ATTATCTAAACATAAACTAGATGTCCAAC CTGAGGCAGGAGAATGGCATGAATCCGG

AATTCAATTCAATTCTGACACTATCTTTGT AGGCGGAGCTTGCAGTGAGCCAAGATCA

CAGAATCCACAGATTTAAGGGTTCAATCC TGCCAGTGCCCGCCAGCCTGGGCATCA

TACAAGACTGCCTCCTCTTGAGTTCCTCT GAGTGAGACGCCATCTCAAAAAAAAAAA

GCCCGGCCGCCCCACTGTCTGGGAAGT AAGAAAAAAAAAAAMGAAAAAAACTCAC

GAGAAGCGCCTCTGCCTAGCCGCCCAC AGCCTGGGCGACAGAGCGAGACTCTGT

CATCTGGGAAGTGAGGAGCACCTCTGCC CTCAAAACAATAATAATAATAAATAAAATT

CGGCCGCCCCACACCACCGCCGCCATC I 1 1 I I I I I 1 1 I GAGATGGAGTATCGCTCT

TGGGAAGTGAGGAGTGCCTCTGCCTGG GTCACCCAGGCTGGAGTGCAGTGGCAC

CCCCCGCAACGTCTGGGAAGTGAGGAG GATCTCAGTTCACTGCAACCTCCACCTC

CGCCTTTGCGCGGCTGCTGTGCGACCCT CCGGGTTCAAGGGATTCTCCTGCCTCAG

CCAAGTGTGAAGTGACAGCCTTGTGTGT CCTCCTGAGTAGCTGGGACTATAGGCAC

GATCTTTCTGCCCTCCCCAAGTTTGCATT GTGCCACCACGCCCAGCTAATTTTTGTAT

TTCGACATTAAAGTTTACTTTTCAATTAAA TTTTAGTAGAGACGGGCTTTCACCATGTA

A I I I I IAAATTGGAGAATATATAATTTAAA GGCCAGGATGGTCTCGATCTCTTGACCT §

AAAAAAAAAAAAAGACTGCCTCCTCTTAA CATGATCCGCTCGGGATTACAGGCGCGA W

GATGCCAGTCACAAGTCCTGGGCTACCA GCCCCCATGCCCAGCCTGTTCAAGAGTT

GTATTTCTGACTAACTGGCTATAAATTAG TTTATAGAACTTACTCTCCAGTCCATTCC

AGGCTCCCACAAACCCCTCCTCAGGTTT TCCTTTCAGTTCCAATCCTCTAATTGCTT

GATAATTTACTAGAACAGCTCATAGAACT GGTCTTTCTGGGGACCAGTCTCATCCTG

CAGGAAACACTTTACCTATGGTACCTAGT ACACTATCTAGAGGTCTCATGAGTAGTCA

TAATAATAGAGGATATAACTGAGGAACAG CCTCATGAGCAGAAATTCAGGTGTATCA

CCAGACTGAAGAAATGCATAGGGCAAGA CAGGGTTTCCTTATGAATAACAAAAGACA

TATGGAAGAGGGTGTGCCAAGCTTCCAT CACCTATTTCTCAGGAAGAAATTCCAAGG

TCCTCTCTG GTTTTAAGCATACTGTGCCATGAACTGG

GAACAATGACCAAATATACTTATCCGTGT

CACTTTCTATATACCAGACTGTGAAAAAT

AAATATACATTTGGTCTCTGCCCTCCAAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs81 12458 19 572251 17 TTACGTTTTGTAATTTCTAGAGAATAAGA A/C AACTTTGCCGTGGCAGGCTGTGCTGATT SEQ_0776

ATTTCATGTTCGTATTTCTTGAGTGTTATA CACGGGACAAGGAAGGTGATTCAAGGG

ACATATTCCATCCAGGATTAAATTTCAGC CCTGGTTGGTGGAGCACTTTTGTCTGATT

CCCGTTCATCTGGAATGTTAATCTCTGGT CATTGCTGGAGACAATCTGCCCTGAATC

AGGTAAGTTTAGCACCTGGTCCACAGGA CATCCTGTTACAGTGTGGGAATGGTGAT

CTATGAGCAGCCCATGATGGGACCTTCA GGGAGCACCAATCCACAATTTAGGGCAG

CTGATCATTTCCAGGAGTGGGCTGATA AGATGTTCAAATTTAAGAAGGCTC I I I I I

ATAAATGCAGAGTCCGAACCCCATCCCC

AGAAATTCTAGCTTGGAATGTCTGGGGA

GTGACTCAAGAATTTGCCTTCTTTTACAA

GCTTCTCAGAGAATGCTGAGGCAGGAAC

CCCA rs7254131 19 57230839 GCTTTTGGTTTGAGAGGCAGTATTTCCAA A/C CCCCTACGTCGGCCTCTCAAAATGCTGG SEQ_0777

ATGCATTATGTTCATGGTATTGTTCCACA GATTACAGGCATGAGCTACCACACCTGG

CTCTTCAGCATCCTTTGATTTTCCAAGTG CCAGGTG I I I I IAAATATCGCTATTTAAT

ATCCTGCAGATGATCATCAACTTCGTTGT GACAATACTACAATAATAGTATAAAAGCA

TTTCTAGGAAAGAAGAGAACAATGAATCC ACTTCATGTATACACTTTGGTAAAAACAT

TTTTATAATCTTGTTGGGGATAAAACTGT AATAATATAAACAAACCAAAAAGTAAAAG

CTTCTTAGAAAAAAAAATCCTTGGTGTTT CAGTCTGTGTGCAAATAAGGTGAGGCAG §

TATTTTGTTTATTATTATTA I I I I I I GAGAC TTGACAATCTATATCGATTTGACAGCTTT *-

AGAGTCTCGCTCTGTTACCCAGGCTGGA CTAAACAGGACCTTGCAAAACATGCGGA

GTGCAGTGGTATGATCTCAGCTCACTGC C

AACCTCCGCCTCCTGGGTTCAACCAATT CTCCTGCCTCAGCCTCCCAAGTAGCTGG GATTACAGGCATGTGCCATCATGCCTAG CTAA I I I I I GTA I I I I I AGTAGAGACAGG GTTTCAATATGTTGGCCAGGCTGGTCTT GAACTCCTGACCTCCAGTGAT rs17779341 19 57242213 CAGGACCTGTGGACTGAAGAGCAAAACA G/T GAAACACAAGACCCTCAATGTAGGCCAA SEQ_0778

ACTTTCAGGGGTACATTCACCTTAACACG ATGCCTTTCTTCGGTGAAGTGTGGAAGT

TGGCCCTGAATATTTGTCTCTTTATTTGG AACATGAAGATGAAAGGGGAGGTCACAA

TTCTCTCAAACCAA AGGAGAATCCACATAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1 1667001 19 57244481 CTCAATGGAAAATTAAAGTCACCTCTGGG C/G GCAGAACATATTCTCTCTGAGAAGCTTGC SEQ_0779 CACCTCAGTCACTATTGTAAATGCGAAGC GGTGGAACTGGCCCATGGAAATGTCTTT GTTTTAGAAGCCGTATAAAAACTGAAGCA AGAAGAGAAGAACCACCTGGCTCTGTTC AGAGAGACTAGAACAAAAAATAAGCGAG TTGACTCTGGAAAAGAATCCTTTTCTAGA CGGTGCGTTGCAGGTAACGGAGCCAGA ATTATTTAGGTTGTTGCCAGATTAATTTC GCCCTTAGGGGAGAGCATCATGGGGGC CTTTAGAGAGTTTCCTTGCCCCCACGACT GGCCATCTTAGGGGACGTTCGGTGTCCG TCCTATCTTTAAAGCCAACAATAGTATGT TAC GAAATCCCTTTCATATTTGAAACCACTGA CTATTGCTGCTGCATCTCTCCGGTTTCTC

CTATTCTTAAGTGCTTGGGCAATCCAGAA

TAATCTCCCAATGCTAAAGTCAGCTGATT

AATAAACTTAATTACAATGCAGAGTCCTT

TTTGCCATGTAACATAACCATGGGAATTA

CTCTGGGGTTGTAGATCTGGCTATGATAT

GATGACACTAATGAATATTTTGCAATAAA

AACATACTATΠTAAAATATATATATACAT

ATATCTTTATATATGTATATTTCTACAGAA

TTATTAC rs12151270 19 57254049 TAATGTTTATAAGACTATAAAAATTGAATA C/G TTCCCTTGTACTTCAGTGAAAAACTTGGA SEQ_0780 4- ACAAAAAAGCCATTTTTCAAAAAGCTGTA GGATCCATAAATCAAGGTGGTATTTTCAG Ul AAAATTTCTGTATGAGGTTATCATAATAA ATTTGTGTGGCAAAAAATTTGTACAGAGA GCATGGCATTCTATAATTTCTCAACTATA GGCTGGGAGCGGTGGCTCACACCTGTA GCAAAACTTCATTTCTATTATTTATTTATT ATCCCAGCACTTTGGGAGGCCGAGGTG TATTATTTATTTATTTATTTTGAGACACAG GGCAGAGCACGAAGAGATCGAGACCATC TTTCACTCCAGCCTGGGTGACAGAGACT CTGGCTAACATGGTGAAACCCTGTCTCT CTGTCTCAAAAAAATAATTGTTATTATTAT ACTAAAAATACAAAAAAAATTAGCCAGGC TATACACTTTCCTAGAAATCATTTAACCC GTGGTGGTGGGCGCCTATAGTCCCAGC AATTTATAGATTTACATTT GACTTGGGAGGCTGAGGCAGGAGAATG GCAAGAACCCGAGAGGTGGAGCTTGAA GTGAGCTGAGATCGCGCCGCTGCACTCC AGCCTGGGCGACAGAGCGAGACTCTGT CTAAAAAAAAAAAAAAAAAAAAAAATATAT ATATATATATATATACACACACACACACA CACACAGAGAAATGACAGATGCAAAGCA TGTGTTCTATCAATATGTAGAAGGTCCCT TACATTTTAAGTTCAGTGAAAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2869602 19 57267389 I I I I I GAGACGGAGTTACGCTCTTGTTGT en TTGATATATAGTTTAGGTTCTCTAGTTCCT SEQ_0781

CCAGGCTGGAGTGCAGTGGTGCAATCTC TG I I I I I CTTCTGTCTGATTGTCCTATTTA GGCTCACTGCAACCTCCACTTCCTGGGT TAAGTAAAAATAGGCCATTGAAGTCTCTT TCAAGCGATTCTCCTGCCTCAGCCTCCC ATTATTACTGTGGAACTACTTCTCCCTTT GAGTAGCTGGGATTACAGGCATCTGCCA AGTTACGTTAATTTTGCTTCACATATTGA CCATGCTTGGCTGAGGGTTTCACTATGTT GGATCTCTATATAGGCACATATTGTTATA GGCCAGGCTGGTCTCGAACTCCTGACCT TCCTCCTAGTGAATTAACCTTTTAATCATT CAGGTGATCCACCTGCCTCAGCCACCCA ATATAATGCCCTTCTTTGTCTCTTGTACC AATTGCTGGGATTACAGGCGTGAGCCAC AGTTTTGACATAAAGTCTATTTTGGCTGA CACACCGGCCTAAGAGTATGTTGTTTCC CATCAGTTTAGCCACCTCTGATGTCTTTC ACATATTTGTTGATAATCTAATTTTCTTCT GGTTAACATTTTGAGGGCATATC I I I I I I GCTGTTGATCTCTAGTTTTATTTTATTATG CATCCCTTCAGTTCAGCCTATGTGTGTCC ATGGGATAAGTTATGCTTTACGATTTTAG TTTGAATTAAAATGAGTATTTTCTGGATA TCTTTAAAAAGTTTAAAA I I I I I I I I C I I I I GTGTGCAGCTGAAGCCAGTTTTAAAAATT CCGATATTTCTTTTGAAAAATGTTTCATGT TATTCAGCCAGTCTCTGTCTTTTGACTGT GCAGTTCTGAAAAATTTGTATTGCACTGT GGAGTATAAACACTTACATTTAATGTAAT TTTTGGGTGATGTGTTATGCATATATAGG TACTGATAGAAAAGGACTTATATTGCCAT TTAGGTTCAA TGTG rs9676397 19 57271815 TACAAAATATTTCACAAACTCATCCATTG A/G TCACCACTAATGTACAAAGAAGGAAGCA SEQ_0782

ATTGCCTCCTTCTGAATGCTTAGTGAACA GAATATCCATAGAAATGGGACAGTTAAAG CTGTAAGATGAAGATATCTAGCTCTCTCC GCCAGATGCAGCATTATGAAGC I I I I I AT CAAGAAATACTGAATCAAAAACACAGGG TTGTGAATCAACAAGGCTTCAGTCTCTGT ATAGGCCAAGCATACTGGCTCAAGCCTG CAAATAATGTAGGGCCTCACAAGAAACA TAATCTCAGCACTTTGGGAGGCCAAGAC CAATAAGGAAAGTACAAAAATGCACAAG GGGAAGATGACTTGAGCACAGGAGTTCA GGAAGATCCTAACTTCTGGAGGAAAACT AGATCAGCCTAGGCAACAGAGTGAAACC A CTGTCTCTACCTGGGCATGGTGTTGCAC ACCCACAGTCCCAGCTACTTGGAAGGCT AAGGTGGGAGGATGGCTTTATCCCAAGA AGCTAAGGTTGCAGTGTGCCAAGATCAC AAGATCACACCACTGCACTCCAGCCTGG GTGACAGACTGAGACTGTGTCAAAAAAA AAAAAAAAAAGCACAAGGATAGAAAACA GGAAGAACAGGGAATTGGATATATTAACT CCGCCATAAGGTTTTACACGTACCTCAG CTCTGGA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1418925 20 52259138 CCCGCAACTCAGCAAGTGCAATGGGTTC A/G CGGAGGCAAAGCTAGCATTTAAACACAG SEQ_0783

CTCTCCACTTTGCAGGTAGAGAAACTTAG GCATTCTGACTCCGGAGTCTGTGTTTTAA

ACACAGAGCAGTTAGAGGCCCTAAAGTG ACTGCTATAGGGGGTCTTTGATGAGAAT

ACTCAGCTAGTAAGAAGCAGAGCTGGAG CTCTTGGCTGGAGGGATTTGCGTTCATT

TTCAAACTCAGGTTTG I I I I I G I ^'l l I I CTC CCACTTTTAAGACCACATTAGAACTTCTT

AAAGCACGCCTGTGTAACCACTAAGCCG TGCTTTGCCCCTATCCAGTACCACATAGT

GCTAAACTTCCATGTGGGG I I I I I AATCC CTATGCCATCTGTGCCTGGTGTAGGGTG

CGTGAGCCTTCCCAGATGTGTAAAGATA ACCCATTGCCCCCTTTTATATGAAATTGA

GTCAGATAGAAGAAAAAGAAAATTGGAG GGGACTGCCAAAAATGGGAAAGCCCCAG

AGGGGGAAGGAGATAACGGCTGATAATT CCAACTCAGGATGTGTTGCTCACCCTAC

TGGGGAGCTTTACAGTGTGCTAGGTACA TATTCTGCCATCCAAAAATTCTTACTGTG

GCTGTAAGTTGTTTTGCGTGTATTGTTTA TCCCAGAGTAGGGTCTAGGGCCATGGTG

TTTTATGTTCTTTGAGGGAGATACTGTTT ATTCAAAAAAGTATGAAACTTTGTGAGAT

TTATCCTTATTTAACAATGAGAAAACAGG TCACTTCACCTCTAGTTTGTTAAATTGGG

C C rs6013925 20 52261484 ATCATACAGACTTGGTAGATATG 1 1 I I IA CfT TCTCCATTTTACAGATGAGAAACCTGAGG SEQ_0784

AAAGTAAAAATAAAAGACTGAAATTGGCC TGGTTCCAAAGAATTGGGTAATTTGCCCA

AGAATTTATTTCTAGGGACCCAGCTGTCA AGGTTCCTGTTTGCTTGGATTGGATTGCA

GTGCAGACTCCGTGTAATACCTAGACTT GCCTGACTCTTCCCACCACTCTGTGTGC §

GGTGTGAGGCATGACTGAGTATGGTTCA TGCCTCAGATACTATAGGATATGAGTTCT <I

GTTTCCTCCTCTAATCCCGTAAGATATTA TCCTAGAGTTCTTCTGACTTTGAGAGTAG

GTTCTCAAGAAAAGAGCCCAGGGAATTT CTACAGCTGGTTTCCCTGAAGGCAGGAG

TAA 1 1 1 1 1 ACTTTGGATcccGAGCAGGCA TTCCTAACCTTTTGGGGTTGTGGATCCCT

TATTTCTCTTTGGCCTAGCAGAATTTCTTT TTGAGAATCTGGTGAAAGCTATGAAGAC

CTAGATCTGGATCTGTTCTTTGTAATGAT CTTCCAGAAGGATGCACATACTATACATG

TTTTGATAAACAATATTCAGGATGTAAAAT CCATTTTGCATACAGTCTCTGGGTATATC

GCTTAGCTATCATTTGACTGACTCCATCA GACCTGTCAATGTCCATTGACCACCCCC

TCAGGCTTTCTCCTACATGTTCATTTTAT ACCCCCCAGTTAAGAATTACCCACTTCTG

CAACCCTATAAGGTAGGAACTAGC GCTGGGCGTGGTGGCTCAAGCCTGTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs6127138 20 52261791 ATCATCAGGCTTTCTCCTACATGTTCATT CfT GGGTATATCGACCTGTCAATGTCCATTGA SEQ_0785 TTATCAACCCTATAAGGTAGGAACTAGCC CCACCCCCACCCCCCAGTTAAGAATTAC TCTCCATTTTACAGATGAGAAACCTGAGG CCACTTCTGGCTGGGCGTGGTGGCTCAA TGGTTCCAAAGAATTGGGTAATTTGCCCA GCCTGTAATCCCAGCACTTTGGGAGGCC AGGTTCCTGTTTGCTTGGATTGGATTGCA GAGGCTGGTGGATCACCTGAGGTTAGGA GCCTGACTCTTCCCACCACTCTGTGTGC GTTCAAGACCAGCCTGGCCAACATGGTG TGCCTCAGATACTATAGGATATGAGTTCT AAACCCCTTCTCTACTAAAAATACGAAAA TCCTAGAGTTCTTCTGACTTTGAGAGTAG TTAGCCGGACATGGTGGCATGTGCATGT CTACAGCTGGTTTCCCTGAAGGCAGGAG AATCTCAGCTACTTGGGAGGCTGAGGCA TTCCTAACCTTTTGGGGTTGTGGATCCCT GGAGAATGGCTTGAACCCGGGAAGTGG TTGAGAATCTGGTGAAAGCTATGAAGAC AGGTTGCAGTGAGCCAAGATCATGCTAC CTTCCAGAAGGATGCACATACTATACATG TGCACTTCAGCCTGGGCGACAGAGTGAG CCATTTTGCATACAGTCTC ACTCTGTCTCACCAAAAAAAAAAAAAAAT TACCCACTTCTTGCCAAAATGCAGCTTCA AGAAATGTAGGAATGTTCTAGGACAGTG AGACTAAAACAGAAGCCTCTGTTAGCCAT CAAAGGCACTGACATCTTACTGTCTGCT GTAAATGGCACTCCACTGGG rs51301 20 52271678 GTTGCAAGCTGTACTGGCCTGTGCTCAA GΓΓ AATGGATGTGAGAGATAATGAAACATTAC SEQ_O786 06 AACCAACTTCTCTTTGGGTTTCTCCTTCT AGTCAGCAGCAAAGCATAGCTGCTCAGA AGCTTCACCTTCGTTTCTCCAATCATTGA AGACTTCTACTACCACTTCCTGTGAAAAG CAAAATTTGTTCATTTCACCCCTTCTCTAA CCTGCACATGACGTATCATATTATGCACC GTCCTGGTGTATCTTTTCTTCAGCCAACT TGACTTTGCAACCTGGCAGTCTCAGGGC GATTCGGCTCACCAGAAAAGGTACAATA CAGATCTGTTGTGCAATTATCTGTTGTGT ACATCCAGTATTTCTACCTCCATCTTTCT AGCCTGCACTGCTTTAAAAAACAAATAGT ACAGTAAAGCCCACCTAACAACTGCCAA GGCCCAGTCTAAAAAGAGTGATTGCACA ATTATTAAAAAGTACTGCTCCTTTCTATTC TGCAAATCAAGATTCCTGCTTAAAAAAAA AAAACCCTTTAGAGACCCCCTGTCGAAA AAAAGAAGTTAGTGACAAATCCAGATCAA CCCTACCTCAAATGGCTTTTCCATCCCCT AACTTCCCTCTGTCGCAACTACTGGCTG TGCTCCCTTACTTAGCCATGCTTTTGACT AAGCTGACATTTCTTCCTTTCCCTTCAGA AGAGCTCACAAGGCTTGGACAAGGATCA TGCACCGCGTGCTGTTCCCCAGTCTTCA CAGTAGTTGTGGAGATGGAAAGAAAT GCTAGCCCAGGGAAGTTACTATTCACAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs292113 20 52272845 TTGGACTTCCCAGGGCATCAGCCACGTG C/T GATGAGAATGCTGAAAGGAGGAGGGAGT SEQ_0787

GAGACATGTAATTGGCAACCGGAAAAGT GTGATCAACAGCAAATAGTACAGTGGCG

GTGTTGAAGTTTAGGATATGCGGGACTA AAGCCAATAAGAGCCGAGAAGATGGAGC

GGGAGGTATATTTGAGAACCCTTTTCATC TCTATTTGATGACTAAGAAGGCCCTTATT

CTACAGAAGGGCTTAACATTTAACGCACA TCCTTCAAAAGAGTTAACCCACCCCTACT

TAAAAATCACCCGGGGATTTTGTGACACT CCTTACACACAAACTGGAGCTCCAAACA

GCAGACTCTGGCTCCGTGTGGGCTCGG CCCTAGACCCCCTGACCCGAGGCCCCC

GCTGAGATGCTGCCTTTCTAACAAGCTC ACACCTGAGCCCCATACCCTTGAACCCC

CCAGGTGACGCTGCTGCTGCTGAGCCCT ACACACACCTGAGCCCCACACACACCTG

GGTGCCATGCATTGGACAGCTAAGGTAG AGCCCCACACACACCTGAGCCCCACACA

CTTGCCACGAAGAAGAGGACGTGGGGA CACCTGAGCCCCCCACACACCTAAGCCT

AAATGCAGGTGGGAGGAAAAAGAAACAG CACACAAAGCTGAGTTCCCATAACCCTG

CAAAGGAGACAGAAGCTGCAACGGTAAT AGCCCCGAAACCTAAGTTTCCCCACCCC

GGGAGATCCGCAAGAGTGTGGAATCCCA TAAGACCCCCACATTTGAGCCCCACACA

GAAGCCA CCCGAGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2585418 20 52277689 TCAAAGCCCCAGATATACTTTCATAGTTC A/G CAGTTCTGCTTGATATGGTTTGGCTTTGT SEQ_0788

CACATGCTTCTCCTTTGTTGCAAGAACAG GTCCCCACCCAAATCTCATGTTGAATCGT

CTATTACATTTATATTGATCATTGCAAATT AATTCCGAACGTTGGGGGAGGGATAGG

ATTGACTTGTCTTCCTCATTAGACTGAAA GTAGAAGGTGATTGGATCATGGGGGCAG

TCAGGAACCATGATAATGCTTTGCTTATT ATTTCCCTCTTGCTGTTCTTGTGATAGTG

CCCATCTTCCCAGCCCCTGCCTACCATG AGTTCTCGTGAAATCTGATGGTTTCAAAG

AAATCAAGCACACGACAGTGCTCAATCTA TGTGTTGCACTTCCCCCTTTGCTGTCTGT

CACTGGAATCCA CTCTCCTAGTCACCCATGGTAAGATGTG

CTTACTTCCTCTTCGCCTTCTGCCATGAT

TGTAAGTTTCCTGAGGCCTCCAGGTCAT

GCTTCCTGTTAAGCCTGCAGAACTGTGA

GTCAATTAAACCTCTTTTCTTCATAAATGA

CTGAGTCTCAGGTAGTCCTTTATAGCAGT

GTGAGAATAGACTAATATACTGCTCCTAG

ATGTGTACCTAATAGACATGAAAACTTGT

GTCCATCAAAATACGTATTAAAGAATGCT

CATGCAATAGTCCTGGTTTACCCTAGGG

GGATAATGTGCCCAGGCCATGCTTGAAA

CCATGGATGGTACTCTATATATATACCAT g

I I I I I CATATATATATATATCTCCATACCT <=^>

ATGATAAAGCTTAATTTACAAATTAACACA

GTAAGAGATTAATAAMTAGAACAATTAT

AAAAACATACTGCAATAAAATTTATGTGA

ATCTGATCTCTTTGTCTAAAATAATATTTT

ATTGTGCTGTACTACGGGTAACTGAAATC

TCACAATGTGAAACTGCAGATAAGTGGG

GACTTACTTGGGTAGTTTTATTCTGAACA

GCCAGAACCTGGAAACAATAATATTATCA

ACAGGAGAATGGACACATACATTGTGGT

CTAGTCATACAATGGAATACAACACAGCA

GTGAAAAAGAACATCTCATTATGACTGCA

AAAAAAAAAAAAAAGCCTGAATCTTACAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs441506 20 52284526 TGGATATTAGCCCTTTGTCAGATGAGTAG A/C AAGCACTTTATTAATATTAACTCATTTAAT SEQ_0789

ATTGCAAAAATTTTCTCCATTCTGTAGGT TCTCATAATTTTATGATGAAGACAGTAGC TGCCTGTTCACTCTGATGGTAGCTTCTTT ATCACCCTTCATTTTACAGACAGGGAAAT TGCTGTGCAGAAGCTCTTTAGTTTAATTA TGAGGCATATAGA I I I I I IAAAAGATTAC GATCCCATTTGTCAATTTTGGCTTTTGTT ACTGGTGAAAGGGGCAGAAAAAAGATTC GCCCTTGCTTTTGGTGTTTTAGACATGAA ACACCTGAGGCGATCGTTGAGTTCTAGA GTCCTTGCCCATGCCTATGTCCTGAATG GTCTGTGTTTTAACAATTTTACTTTCTTGC GTATTGCCTAGGTTTTCTTCTAGGGTTTT TTTTAGAACAATGAAGAACAATGGAACAA TATGGCTTTAGGTCTAACATTTAAGTCTT CATATATAATATCTTAGCACAGTACTCAA TAATCCATCTTGAATTAATTTTTGTATAAG TACATATTAAGTGCTCAATATGTGGCTGC GTGTAAGGAAGGGATCCAGTTTCAGCTT TATTATTATTATTAAAGATACACTTCCATT TGTACATATGGCTAGAACTAAATTTTAAA GTGGCATTGGCTGGCAATGGCAGATCCT CTGGCCATCTTAATGGGATACAACAGGG GCATATAACAAAGATTTTATGAGGTTTTG CTTCCAAATAAGACTAGTTTCCTTATTGG ATGAAAGCTGACCTGAAGC GAAAATGAATATGACAATGCCTGTATCAT TGTTCTATTGTAAGAAATAAGAAATGCTT ACACACACACAATGCTCTCTGTGTGCTG AGCTCTACAC rs6013938 20 52289279 AGCACTCAAAACTTTGGAAGGATTTTAAG A/G TGTAGAAATGTCATGGGCGACCAGAGGT SEQJ3790

O

ATGCTTCATAGAGTCATTTGTCTAATTGG GGTTTAGTGTTTCTGAAGCTTGGAGAAA ATATCTAGGAGAGCAATATCTAGGAAGAA GGGAATTTGAAGATACTTTTCAGGTAGCA TGCACTCATTTCAGAAAACGAAAAGTTAT TACACGTGGTGTGTCACGGTAAACCATA TTGTAATTATAATAGCGGGCTTTTCTGCC AGAAATTCTCATTGCTTACATGAAAGAGA TC I I I I I GGAACTGGTAGTGAGCATGCTG CTTGGTTTGCTTCAAGAGCAAAACAATAA GCTCAGTTCCTCACCCTATGCCTCCTTTT AAATGGTTTTTGAAACAAAAGTAATTTAG CTTGCTTTTAAATCTTCTCCATTATCTCCT GCATCCAGTTTGTTTTTCGGAAATAAAAA TTATTATCTGCTATTTATTTTACTGAAGGT CTCAAATGTGAATTCATTTTGAAGCTGGT AATCACTGCTTTATTAATCACTGCTTGAG AATTACATTTTGTTTCTAATGTAGTTGTAA TAACCACAGTGGGACTTGAAATGAGCTT GAAAGACTTATAAAAACTGGATTTCAAAT GTTTGGATTGTAAAAGTCACAAATGCTGG AGCTTTTGCAAAATAACCTTTGCGTTTAG TGGACCTCTTGAAATTTCCC I I I I I CCCT TTAAATAATCAGGGCCAGGGGTGGTGGC TCACTTTTATGAGAACTTCCAC TCACGCCTGTAATCCCAGCACTTTGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2870319 20 52294822 AGTTTG I I I I I CGGAAATAAAAACTCAAA A/G ATGTTTGATTTTCCATTGCTGAGTTACTT SEQ 0791

TGTGAATTCATTTTGAAGCTGGTAATTAC CACTTAGAATAATGACCTCCAGCATCATC ATTTTGTTTCTAATGTAGTTGTAAGAAAG CAAGTTGCATTCCTTTTTATGGCTGAGTA ACTTATAAAAACTGGATTTCAAATAGCTTT GTATTCCATGGTGTATATATACCACATCT TGCAAAATAACCTTTGCGTTTAGTTAAAT TCTTTACCCACTCATTGGTTGATGGGCAT AATCAGGGCCAGGCGTGGTGGCTCACG TTAGGTTGGTTCCATA I I I I I GCAATTGC CCTGTAATCCCAGCACTTTGGGAGACTG AAATTGTGCTGCAATAAACGTGAATGTGC AGGCGGGTGGATCACCTGAGGTCAGGA ATATGTCTTTTTAATATCATGACTTATTTT GTTCGAGACTAGATGGAGAAACCCCATC TCTTTGGGTAGGTACCCAGTAGTGGGAT TCTACTAAAAATACAAAATTAGCCGGGCG TACTGGATCTAATGGTAGTTCTACTTTTA TGGTGGTGCATGCCTGTAATCCCAGCTA G I I I I I CAAGGATTCCTGTGAGTGAGTTT CTCAGAAGGCTGAGGCAGGAGAATTGCT TTGAGCAAGTTCCCTAACCCCAGATTTCA TGAACCTGGGAGGCAGAGGTTGCAGTGA GCTGCACGTTGTACTTATTCAGGTTAAGC GCAAGATCACGCCATTGCACTCCAGCCT CTGGAAATGATCCCATCTCTAACCAGCCT GGGCAACAAGAGCGAAACTCCGTCTCAA CTGCTCCCAACATCCAGTCTACCACCAA AAAAAAAAAAAAAAAAATCAGAAGGGAAT ACCCAGGCAATTTTACCCTCAAAGAACC TTCAATTTTCCTTGAAATACTACTAGATCT GTTGGAAACTCCTAATGTA I I I I I CTTAC TAGAAAGTAGGGGCGTTATCACCGCAM AGTTTTCATTATGGAAAATAGTAAGCATT AACATGCCAAATTGTAAGGACCATCGAT TACAGAATAAAGATAATACCATAATGAAT

O GCTAAGAAGAGACTGCATCAACTAACGA CCCTGTGTAGCTATCACCCAGCCTCCAA K* GCAAAATAACCAGCTAACATCATAATGAC AATATTATATTCAACTCATGTCCAGTTTTA AGGATCAAGTTCACACATAACAATATTAA TTTTCTCTCCTCTCCATTTCCTCCACTTCA TCTTAACTGTAAATGTGCTAAATGCTCCA GTGTATTTTGAAGCCTATCTCAAGTATCA ATTAAAAGACACAGACTGGCAAATTGGAT TATTATTTCTGCTGTAAATATTTCAACATA AAAGAGTCAAGACCCATCAGTGTGCTGT CTTTTCTAAAAAATACAATATTCCTTACTT ATTCAGGAAACCCATCTCATGTGCAGAG GAAAATTATAATTTCTTAATATTATCAAAT ACACACATAGGCTCAAAATAAAGGGATG ATCTAGTCATAGTGCACATTTGTATGATT GAGGAAGATCTACCAAGCAAATGGAAAA AGCTTATGATTTTTACAGTATG ! I I I I I CA CAAAAAAAGGCAGGGGTTGCAGTACTAG AATCAAACAGTTTCATACATAGCAATTGG TCTCTGATAAAACAGACGTTAAACCAACA TGGATATGTTTCTTATCC I I I I IAATCATC AAGATCAAAAGAGACAAAGAAGGCCATT TCA I I I I I I I CTTATTTGTTTATTGAATAAA GGATAATGGTAAAGGGATCAATTCAACAA CTAGGTCATCTATCTGTTAGAATTTCCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs368933 20 52295658 TGTAGTTGTAAGAAAGACTTATAAAAACT A/T GCAATTGGTGGATATGTTTCTTATCCTTT SEQ_0792

GGATTTCAAATAGCTTTTGCAAAATAACC TTAATCATCTCA I I I I I I I CTTATTTGTTTA

TTTGCGTTTAGTTAAATAATCAGGGCCAG TTGAATAAACTAGGTCATCTATCTGTTAG

GCGTGGTGGCTCACGCCTGTAATCCCAG AATTTCCAGCCCTCTGCATCTTTATGATT

CACTTTGGGAGACTGAGGCGGGTGGATC TCATCTGTGTGGCTGACGTAGAGATGTA

ACCTGAGGTCAGGAGTTCGAGACTAGAT CCACCCAGATCCCACTTCAGGAAGGTCT

GGAGAAACCCCATCTCTACTAAAAATACA TGTTGCACAGTTGCTGGGAATGTGAGCA

AAATTAGCCGGGCGTGGTGGTGCATGCC GCAGACAGATTCCCTCTTCCAGCTTTCA

TGTAATCCCAGCTACTCAGAAGGCTGAG GTTCC

GCAGGAGAATTGCTTGAACCTGGGAGGC

AGAGGTTGCAGTGAGCAAGATCACGCCA

TTGCACTCCAGCCTGGGCAACAAGAGCG

AAACTCCGTCTCAAAAAAAAAAAAAAAAA

AATCAGAAGGGAATTTCAATTTTCCTTGA

AATACTACTAGATCTTAGAAAGTAGGGGC

GTTATCACCGCAAAAACATGCCAAATTGT

AAGGACCATCGATGCTAAGAAGAGACTG

CATCAACTAACGAGCAAAATAACCAGCTA

ACATCATAATGACAGGATCAAGTTCACAC O

ATAACAATATTAATCTTAACTGTAAATGTG

CTAAATGCTCCAATTAAAAGACACAGACT

GGCAAATTGGATAAAGAGTCAAGACCCA

TCAGTGTGCTGTATTCAGGAAACCCATCT

CATGTGCAGAGACACACATAGGCTCAAA

ATAAAGGGATGGAGGAAGATCTACCAAG

CAAATGGAAAACAAAAAAAGGCAGGGGT

TGCAGTACTAGTCTCTGATAAAACAGACG

TTAAACCAACAAAGATCAAAAGAGACAAA

GAAGGCCATTGGATAATGGTAAAGGGAT

CAATTCAACAAGAAGAACTAACTATCTTA

AATATATATGCACCCAATATGGGAGCACC

CAGATTCATAAAGCAAGTCCTTAGAGAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs292123 20 52306099 CCTGGGACTAGTTAGGAACGTCATAGAG A/G TGGACGAAATGAGTGCTCTGAAGGTTGT SEQ_0793

CTTGACCCACCTCCAGATCAGGGAGACA GCTCTTTGGAACCTCTGCCACTGGCATC^' AATTTCAGCGTTGCCTCTACCTCCTTGCC ATTTCCCAAGTGAAAAAAAAAATGGCTGC AGTCMCTTGCAGTGAAGCTTTTTCTTGT CAACAACGCAGACAAAAAGCTAAGTGAA CTCAAAAGCTGGTGCCATAATAGGGGCT AATGAATACAGGATCTGTCTCTAATAAAA TCTCTGCACGCCAGGTATGAATTGACTG ACAGAAAAAGAATTATGCTTAGAAATATT CTCAATAACATAATCATTATTCATTAAATT CATCACTGGTGCACGATGATCCAGATTT ACCTTTGCACCATTATCAAAAGTTAACTG C ACAATATGTATGCAGATTTA I I I I I ATTCT GTATTCTGTTTATGGCAGCTTTGTATCTA CTTTCTTGAGCAAACACATGTACCAAACA CAGTTAACAGCACTTTACAAATAATAACT CATTTAGTACTCATTACAACCCTCATGGC ATCTGCTTCTAATGGTTCTATTTTCTTGG CAAGGAACCTGAGGCACGGAGAGGCTA AGTAGATTTCCTAGGGTCACACAGCCTG TAATTGATGGCACTTAGCTTCTATTTTCTT CTCTCATTGTAAATCATCCTTTAGTATAAT TGTGGATTTGGTTGTCTGAA I I I H CACT AGTTGGTAAGCTGTTTGAGGGTAGAGAT TGCGTCTTTAAGCTTTGTGGCCTAAGCAC TTAGCTAATGCCAGCCTTGGAGAACATG CTCCATGAAGGTGTATAAATGAACGAATG AATGAATGGGCAAATGCACAAAGT rs292125 20 52306234 GGAGAGGCTAAGTAGATTTCCTAGGGTC CfT AATAAAAACAGAAAAAGAATTATGCTTAG SEQ_0794

ACACAGCCTGTAATTGATGGCACTTAGCT AAATATTCATCACTGGTGCACGATGATCC TCTATTTTCTTCTCTCATTGTAAATCATCC AGATTTCAACAGATCAACCTTGATATGCT TTTAGTATAATTGTGGATTTGGTTGTCTG GATAAGAGACTATTTGTGGAAAGACTGAA AA I I I I I CACTAGTTGGTAAGCTGTTTGA CCTTGGAGGCCACACTGCAGGGCTCCAC GGGTAGAGATTGCGTCTTTAAGCTTTGT CGGAGATATGACAATTGCCAACATCTGTA GGCCTAAGCACTTAGCTAATGCCAGCCT TGGGAATTAAGGGATGGAGACATGAGGT TGGAGAACATGCTCCATGAAGGTGTATA TAATTGCCAGGGCTTTAAGAGGCAGGAG AATGAACGAATGAATGAATGGGCAAATG AGGAGGAGGTGGAAGAATTATAAGAATC CACAAAGTATGGACGAAATGAGTGCTCT ATGGTGCTGTTAGTGGGAACAGCCAAGG GAAGGTTGTGCTCTTTGGAACCTCTGCC CTCTGGAGTTGGCAAAGAAGATTAAGCT ACTGGCATCATTTCCCAAGTGAAAAAAAA GCGGGTGACAGGCAGGTGGAGGGAAAC AATGGCTGCCAACAACGCAGACAAAAAG CCAGCACATCCCACTGGCTCAAGGTGAC CTAAGTGAAAATGAATACAGGATCTGTCT CTTTCTTTCTTTTCTTTTCCTTTTATGATTA C A

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs292126 20 52306917 AGGCTCTGGAGTTGGCAAAGAAGATTAA C/T AGCTCTTTGTTGCTTACTTTAGCTGCAGA

GCTGCGGGTGACAGGCAGGTGGAGGGA TTAGAATCATCTGAAGA I I I I I GTTTTATT AACCCAGCACATCCCACTGGCTCAAGGT TATAAATGATGACTGCAGAAGCCTCAGTC GACCTTTCTTTCTTTTCTTTTCCTTTTATG CCAGAGAATCTGATAGCTTTG I I I I I GGG ATTAAAGGACAATCATGCTTGTGGTTACA TATGGCCTAGATATTGGCGTGTTCCCCA ACTGTCAACAGAAAAGGAGGGTAGAAAT CATGATTCTACTATGCAGCCAGATGGAA TAAAAAGTCTCCAAACTTCCTTGGTTCCC GTACAACTGATTCTCAAGTCAAGTTGCAC CTGAGAGAGTTCATAAGATTGACTTTGAT CAGAATTACTTTATTTCCCTTAACTATGGT TCCAGACATTTTTCTGGATACATACAGTG TATTAGCCAAGCCCCTGATTAGAGAGTCT ATCTATCATAAATATCTAACTAGCAGGCA GATTCAGTCCTTTTGGAATGGGGTCAGG AA I I I I I GTGTTTCCCTCACCTCAGGGAG GCAGTGGTA I I I I I I I I I CTCTGTTCCCC TCCTCTTACTTCCAAGTCTTTCCAAAGTT AGGTGCAGCTATGGTTGACTCACTGCTG TCTCATATTCCAGAAAACATATTTTCTAAT CCTGAAGCTTTTGCAATCCATGCTAATGG TTTAI I I I IA I I I I I I GCACAACGAA GAGATGTGTTGGAGGGGAACCTTAT rs11266889 20 5231391 1 ^Λ5 AATTTGGTAATTATAGTTAGCAAATGGCC -/C/T CCCCCACAGTGGAAACGTTATGCTTAGA SEQ_0796

2313912 CTTTGGCAACAGAATGTC I I I I I I AAAAG TTGCATGTTGCTCATCTAATATCCTTGAT CTCAACAAAAATAATTCTGGGGAAAATAA ATGAGCTTTAATAATATTGAAAGACTTGC AAAGGCATAATCTGTGAAATGCTGAATGT TATTCAGCTGCCTAACAGTTCTAAAGTGG Ul

O AAACTATACCGCATGACCTAATTAAGAGG ATATCTGGCCTAGCCACCAGATTGAAGA ACTGCTATGGAGGATTTTTCCAAAATACT ATGTGAAAGAGCTTATTCAGCCACGTTAA CAATAAAATGAGCCTTATTATGGCAGTTT TGAACAAAGTCAATGACTACTCCGTTACT GGGGGAAAGTAAGCCTATTTGTTTCGGA TCCTGTCAGTTCACTCATCCCTCCATCCC GGTGCAAATGCCAGATAATATAATATTAA TCCTCCTGTCTACGTTTTCATTAAAATGTT AAGAAGATAGATTCAAAAGCAAAAGAGAT GATTGAATATTCCCTACGTCTCTGGCACT TACTGTGAAGAGCAGATAAATGAAGTGTA GCTCAAAGTGCTGGAGCTACAGCAGGGA AGCACATTTAGTGTTAAAGACAA I I I I I I I ACAAAATAAACAAGGTTCTGTTCATATGG TTCACTGCTACAATATCTGGTACTGCAGA AACTTACATTTTAGTGGATGTTGGGTTGG CACATGGAAATTTAAAGG I I I I I AGAAATATGACAAATAAAGATAAAT rs292148 20 52328127 TTAGTATATTTGACTG I I I I I GTCCCAGC C/T ATAGCCTCAGTATAAAGTTGCTTTAGAAT SEQJD797

TCAGGTCTACTCTAGACTTGGGGCCTTTA TCTCTTGATAAGAAGCAATGCAGAAAAAA AAAAGATTAAGTTCGGAGAGCTAAGAGA TGTGATCATCATAGTGGGGGGTGTCGGG TAAGATTCCTGCAGTTTGAGGGTCTTTTT GGGGTAGAACTCAGATAGCTTTGGCCTT I I I I I I I I I I IAAACCTCATTAAAACCTTG CC i 1 1 1 1 i i 1 1 1 1 i 1 1 1 1 1 1 1 1 I CTTGTTTG ATTC I I I I I I CTATGCAGTTATAAACCTTA GTTCCAAGTTTTCATCTTCTCTGCATTTC GTAAATTTGCCTGCTGGGAAAAGACAGA CAAACAGATGCTGAATTCTCGTTTGTCCC TGAAACAAATGGCCTTCTACTTAAATGGC TAATGGACACATCAAGTGTACTCTAGTCG TTTTACCTGAATTTAATTTCATCTATG CTGTGTCTGCTTTGCTGTGAGTAGTTTGC AATTCCTATGATTAAATATGCAATTAAGAT TTAAATACAATAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1542522 20 52343629 AGAATAAACGGTTATACAGATCCTTTCCC C/T TGTTGTGCTTTTCTATAATATTTTAGGTAT SEQ 0798

GTTCCGTTTCTGTTTCCAGCCTGCCATTT ATTAATCATAAATCCTGGAATTGTTTATCT TTACCTCACTGCAAAGAGAAAATGGAATT ACAAAAAATTGAAGTCAGGGAGTCATGG GATGGAGATATAGGAAAAATATGTATGTA AATAGTCATTTATCATGGGCTTTGGCTCA TGTGTGTATAGATACAAACCAATATATCT GTGACTTGAAACTAAAAGTAGAAGAAAAA ATATATATTTACATTGGTACCCAGTAAGA CAAAAGCACTGATTGTGTAGAGGTGGCC GTGAAAACTCTAAATGGTTGTTGTCAGG AAATGCCTGGAGGTTAAGTGAAATGAAAT GACAATGTGTGTTTTCCCAGATTTTGTTC TAAAGAAAAAAGAAGTCCTCTCTGATCCT TGTGAATTGAAACCGACTTTGCTATTATA TAGCAGAAATTATTCACTTTCTGAAAGAA AATGCATCACTATAATTGCCCTGATTTAG GCTTTTTCTCTATTGAGACTTCTATTTGG CCTGGCAGTTATGACTCCTGCTCAGAGC AAATGTATATTATAGA I N I I I I I I GCCTG CAAATGTCTCCCAGCCAAGACCCAGTGA TTMTCTGCTAAATGTTCATTTAACAATAG GCTTGCCAAATTGTTTCACCTCTTTTATT AAAATGTTTGATAATAAAACCATTGCTTTT GTCAGAACTCATCGCCCCTCCTCACA TCTGATAGAGGTACTTCAAT rs1542523 20 52343709 TGGAATTGATGGAGATATAGGAAAAATAT A/G AGTCATGGAATAGTCATTTATCATGGGCT SEQ_0799

GTATGTATGTGTGTATAGATACAAACCAA TTGGCTCAGTGACTTGAAACTAAAAGTAG TATATCTATATATATTTACATTGGTACCCA AAGAAAAACAAAAGCACTGATTGTGTAGA GTAAGAGTGAAAACTCTAAATGGTTGTTG GGTGGCCAAATGCCTGGAGGTTAAGTGA TCAGGGACAATGTGTGTTTTCCCAGATTT AATGAAATTAAAGAAAAAAGAAGTCCTCT TGTTCTGTGAATTGAAACCGACTTTGCTA CTGATCCTTAGCAGAAATTATTCACTTTC TTATAAATGCATCACTATAATTGCCCTGA TGAAAGAAGC I I H I CTCTATTGAGACTT TTTAGCCTGGCAGTTATGACTCCTGCTCA CTATTTGGAAATGTATATTATAGA M I I I I GAGCCAAATGTCTCCCAGCCAAGACCCA TTTGCCTGTTAATCTGCTAAATGTTCATTT GTGAGCTTGCCAAATTGTTTCACCTCTTT AACAATAGAAAATGTTTGATAATAAAACC TATTGTCAGAACTCATCGCCCCTCCTCAC ATTGCTTTTTCTGATAGAGGTACTTCAAT ACTGTTGTGCTTTTCTATAATATTTTAGGT TATGAGGATTTTATAAACGTGTTCTAAGT ATATTAATCATAAATCCTGGAATTGTTTAT ATTCAATGCTTAATAGTGGGGTTGCTATA CTACAAAAAATTGAAGTCAGG CTATTGGGTGAGATATCAACCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2870320 20 52349569 TTTTGAGGGTCTTTAAGTTGGTAAATGAC CfT GTGAATATGAGAAAAAGATGGGATTACTC SEQ_0800

AAATAAATAAATACGTGCAACTTAGCAGA ATGGACCATTGA I I I I I I CATTTGCTATTG

AATATGGTATTTTGCTATTTAAGAGCAAA TAGTAAATCCTCTAGTTTACCTTGTATTA

CTGGTAATCATGAGATAMCTTTTGATGG GATCAATTAAACCTAGAGTCATAAGACTT

ACCTTGAAATGCACTAACTCATAGGCTTA TGTTTCAAACTAACTGTGAACTTGGACCA

ATAGCAACAATTCTTTGTTCTATGTAATTA ATCAATCAGTCACTAAGCCTATGAGTTAG

ACACACTGGCTCAAAAAACAAGTATCTAT TGCATTTCAAGGTCAATCAAAAGTTTATC

TTCTGGCAGGGAGAATAAAGCAGAAAAC TCATGATTACCAGTTTGCTCTTAAATAGT

AATCACACTATAGTTTTCTCTGGAATGTA AAAATACCATATTTCTGCTAAGTTGCACG

TCAGCAAATATGTACCCTTCTGTACACTT TATTTATTTATTTGTCATTTACCAACTTAA

AGCTGGTGAACATCCAAGAAGCTATTTG AMCCTCTCCAAGTCTAAATTTCCTCTTA

ACTTTCTCAAGAGATGGTAGATTCCTGCT TATAATGTTCATTCATTTATGTGCCTATCA

AGAGTCTAGTTCTCAACGATATTTGTTAG CAGGTATTTGTGTCTTATACTATTCTAGA

TATATTATCTTAAAAGCCTCCTACATTTAA AGTTGGAAATGCAGTGATGAACAAGAGA

CTTTTGAAACCCGTTTTATGAAGCATTTA GAGAGTTCCTTCTCACATGCCCTTACATT

AATGTGAAGTTTGTTGAATTATCTGCAAG TTAGTGGGGGGCACAAAATAATCACATA

TAATACGGTTATTTTATACATGGAACCAG GCTATACGACAAGGCAGTTGATATGTGC

TAGG TAGGA

'Jl

O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1293144 20 52350615 CTTGTCAACCTGGTTTGAACATTCATTTT A/C TAAATCTAGAAGACAAAGAGATAGTACCT SEQ_0801

AATAAGACTAATACACATGAATAGTTTTC TTGAAAGGCATCTAGACTGCAACCATTTC

AAAAATGTTGTTAAGGGAAAAATGAGCAT TCCCCAACTCTGCCCACTGGCAATACCC

TATAAAGAAGTTAAGTCAGCAGCTAAATA ACACAATCGCTTTTGCCTTTCACCTCGGC

AAAATGCATATGAGATGGCTTTTCTTMC TAATGCAAGTGTTGCTCCATTCAATGACA

AGGATAGGACACACACAAAGTGTTCTTA ATTCATCCCTATTTGATTCCTTATTATTCA CATATGTTATCTTATTTAATGGTCTTC I I I I I CACCCAGCAGCCACATTGATACCT

TTAAAACCTAAGTCAGATGATGTCACTTC TCTGCTCAAAATCCTACAGTGGCTTCCTC

GGTCTGTCAGATAAATTCCAGAATCCTTA TGGTGAAACACAGACAGCTCTCATCATCT CGACAAACTTCACACTTCCCTTCTCATAA CTCTΠΓGGGTTTGAACCACCTGGTGGTC

CTTCTGTTCCTAAAACACATCAGACACTT

TCCAATGTATTGCCTTAAACCCTGCCTCC

GGGTTTCTGTATGACCCTGTGCCTTCTTT

CCTTCAGAGGTCTGTTCTCAACAGAGCA

GCCTTCCCTAACTTCTTATCTGAAATTGC

ACCCTCCACAACCCTGATAATGTTTCCTC CΛ

CTAGCACATATCAACTGCCTTGTCGTATA OC

GCTATGTGATTATΠTGTGCCCCCCACTA

AAATGTAAGGGCATGTGAGAAGGAACTC

TCTCTCTTGTTCATCACTGCATTTCCAAC

TTCTAGAATAGTATAAGACACAAATACCT

GTGATAGGCACATAAATGAATGAACATTA

TATAAGAGGAAATTTAGACTTGGAGAGGT

TTTTAAGTTGGTAAATGACAAATAAATAAA

TACGTGCAACTTAGCAGAAATATGGTATT

TTACTATTTAAGAGCAAACTGGTAATCAT

GAGATAAACTTTTGATTGACCTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1293143 20 52351866 TACCAATCAGTAAGAAATCATTGAAAAAA A/G AGCCAACTCCCCTAATAAATTCCCTCTCA SEQ_0802

CAAAGAGGGGGGGAAAAAACTCTTACTT TATATCTATATCTATGTCTATATATGTCTG

TTATTTAAAGCCCAAAGAAATGTGGACAC TGTCTATGTCTAGATACACACATCTGCGT

AAAGAAATCTAGAAGTAAAACCTCCACAG CTGTGTCTGAGTCTATATCTACATGTCTA

GGAATGAGCTCCTCCTAGATGAGCAAGG CGTGTATATCCATGTCTGTCTATATCTAT

GCAAAGAATGTTTGCATGCTTAGGACCA GTCTGTGTCTGTGTCTATGTCTACGTCTA

CTTGTTGGGGTTGGAGATAAGGCAGGCA CAGCTATATCTATGTCTGTATCTATATCT

GATGTGCTATAAGTGTGAAATACAAACTA GTGTCTATGTCTGTATGTCTGGATTTGTG

GACTCAAAAGGCTTAGTACCAAAAATATG TCTGTGTCTATGTCTATATCTGTATGTGT

TGAACTATCTCAACAATGAC I I I I IATATT CTGTGTCTATGTCTATATATCTATATCTAT

GATTGCATATTGAAATTATAATACCTTGA GTCTGTCTATAGCTACATGTCTGTGTCTA

ATATATTGCATGTGATGGTTAATTTTAGG TGTATATGTCTATATCTATGTCTATACATA

TGTCAGCTTGACTGAATGAAGGAATACCT CACATTCAGTAGGCCCTCTGTCCCTGCA

AGAGAGCTGGTAGAGCACTATGTCTGGG GGTTCCACATCCTCTGATTTGACCAACCA

TGTGCCTGTGAGGGAGTTTCCAGAGGAA CAAAACCACAATATTTGAAAGAAATTAAA

ACTGGTGCCTGAGTCAATGGACTGCGTG CCCCCCCAATACAACAATAAAAATAATGC

GGGAAGATCTCCCTCAGTGCGGGTGGG AAATTTAAAACACAGTATAACAACTATTTA

CACCATACCATGGGCTGGGGGCCAAGAT CATAGCATTTAAATTGTATTAGGTATTATG

AGAATAAAAAAGGAAAGGAAAGGATTTCT AGGACTCTAGAGATGATTTAAAATACATG 'Ji

TTTCTATCTCCCCTTCAGAGCTGGGACTC GGAGTGTGTGCATAGGTTATATGCAATTA VO

TTTCTTCCTCCTGCTCCTGGCCATCAGTA CTATACCATTTTGTATAAGGAACTTGTAT

CTCCAGGCCCTCTGTCCTGGGTACCCAA GTCTGCAAATTTTGGTATCTGAGAGGACA

GGATTTGTGCCAGCACCTCCCTGGGTCC TCCTAGAACCAGTCCCCCACAGATACTG

TGAAGCATTCAGTTTCAGACTGAGGATTA AGGGATGACTGTATATACATATCCTATCA

TGTCATTGGTTTCCCTGGTTCAGAGGCTT GTTCTGTCTCTATGGGAATGCTGACTAAT

TTGGACTTGAGCTAAGCCATGCTCCCAG ACACTGGGTTAAATACAATAGATATAAAA

CATCCCAGGGGCTCCAGAATGTAGACGG ATTGATTTTACA I I I I I I I I ATGTΠTATGA

ACTATCATGAGCCTTCTCAGCTTCCATAA TGTGCCTGCTACAAAATCTAAATTTACAT

TCCTGT GGATGGTTTATATTTATTTTAGATAATGTT

AGACAACAACACACAAAACAACCACCCT

AAATTGTCCAACAAATCACTTATAAAATG

CAACCTTCTTCCTCATTTAATAA I I I I I AT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1293140 20 52353572 TTAGATAAGCTTGCCGTGCAGGAACTGC A/G GAATATCTGGAGAGAAGATGTCAGATCC SEQ_0803

CTGGTGGAGAGAAGGTAACAGTTACAAT CCTCTCTCTAAGAGCTGTCTAAGCACAG

TGCATTCTTAAAGAGCGAAGTAAGAGGT GAGTGAGTCACCACAGCCATGTTTATAT

GAACACACAAGGAAAAACAGAAAAGGTA GGAAAGACCCTGGCCCTTGGCAAGAGCT

AAGATAACTTTTAGGAAAATGGGGCTCTC GATTGGACTAAGAGTGGACCCCTCATGA

AGTTACAATAGCTGGTTAGACACTTCCAA AAGTTGTGCTAAGCAGTTTCTCCTTCCTA

ATTAGTTTCTGGAAAAAAAAAAGATGGTT GGAGTGTGGAATAGGACACTGACATGTT

AGACAGTTCTAAATTAG I I I I I GAGAATA GGTCAGCTGAAGGGAAAAGAGCTGGGA

AGATTGACATTTAATATGTATGCTAATTG AACAATATTGTGCCATGGCAAGGGTGGC

ATGTCAGACATTTCATAAATATATACCAAT CAATTTTCTTTATGTAAAACGAAGCAGAG

ATGGCCTCCAATAATAATGTCCAAATAAT AAAACTGAAAAGAGAAGAAAAAAAGTGAA

ACTTTACACTAAGGCTC I I L I I GGTGAGT GCACAAATGTGTAACTACCAGACACCTG

ATGAGTGAGATTGGAGCAAAGTGAGTTA AGCCCCAGAGCGAGAATAATGAAAAAGA

GAGGGTTCTA I I I I IAAATCACCTATT CCTTCCTTGCTGGGCGCAGTGGCTCATG

CCTGTA

CΛ

O

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1293135 20 52360876 CACTTCTAAAATAGCTCATCTCTCCTATTT C/T GTAATGAACTCTTTAAAGACCTTATCTCC SEQ_0804

TTCAGTAGAAGGCCCTTTCTGCTAGTAGA AAATACAATTACATTCTGTGGTACTATGG AGTCCTTACATTTCACACTTCTGTTGGAC GTTAGAGCTTTAACGTGGTAATTTTGAAG ACCTTCATCTTTTCCACCCCTGCTTCAAT GAACACAGTTTACTCTATAACACCAAGAT CCCTGCCTGGCAAATGCATTTCTCTTTTC TTCTAGATTAGTTTTCTCTTTATTTTCATT I I I I C I I I I I I I I I CTTTCTTTCTGACTGA CTACCATCCCACCTCAAGTCATTTTATCT GTTTCGCTCTTGTTGCCCAGGCTGGGGT CCACTTCTTA I I I I I C I I I l I I I CCATCAA GCAATGGCACGATCATGGCTCACTGCAA GTTTGTTTGGCTGTTCAGTTGGTTTTCTT CCTCCGCCTCCCAGGTTCAAGCGATTCT AGAAGATTGCTTTGATTATGTAGTGATTC CCTGCCTCAACCTCCTGAGTAGCTGGGA AGGACTTGGGTTTGAAGTTACTTCTCACT TTACAGGCACCCGCCACCACGTCCAGCT TTTAATATTATTTATATATATATGACTTTG AG I I I I I I I GTATTTTTAGTAGAGATGGG GGGATATTATTATGCCTTTCTATGCCCAG ATTTCACTATGTTGGCCAGGCTGGTCTC TTTTCTCATCTGTAAAATGGAGTAATAATA GAACTCCTGACCTCAGGTGATCCACCTG GTTCCTGCATATTATGTTAGTACCTGTAC CCTCGGCCTCCCAAAGTGCTGGGATTAC CACTGATGGTTCATAAAGTGA I I I I IAGG AGGTGTGAGCCACTGCACCTAGTTGGCA TGGAGTGTCCAAGTTTAATTTTTAAAAAA AATGAATTTCTAAGTCAAGATATTTCATCA CCTTCTACTGATGACAAAGGATGCTTACT GAATAGTTTGTACCTCTGGAGTATTTCTT TTCTCTTCATAGCAGTAATTCAAAATTTTC TCCTAGGGTTGCAGTAAGAAAGCATGAC TTTATAAATAAAATACGAGTTATTTAAAGT Ul AGACTGGGTAGTGTAATCAACAGATTAAT AACTCTGACCTTCAATCTTTTATTATCATG TTTCTCACAATTCTGGAGGCTGAAAGTCT AGAATAATTTCTGAAATAGTATTGTCCTTA GAGATCATTGTGTCTCCTTGGTTGTCAG TTGCAAATGAATATATGTTTATTGTTTTAA GGTTGCTTTCTTCTGAGGCTTCTCTTCTT AAATTAGGAAAT GGCTTTTGGATAGCTGTCTTTCCTCTGTG TTGTCACATGACCTCCCTTCTATTTGCCT CAATATCCTTATCTCCTCTTCTTATMGG ATACCAGTCCTATTGGATTAGGATTCATT CTGACAGCCTCATTTTAA rs4809962 20 52364555 TCTTCACAACAACCTGGTGAGCTAGATG C/T AAGGGAGCATGAGCAAGGAGGGCGAGC SEQ_0805

CTTATGTCTG I I I I IAGCATGTGGAAGAT AGGCTACCGTGGATGGGTGCAGCTGGA TAATTCAGGGTTTGAAAGTATTTTGTTTAA GAGGGTGCAGTGAAAGAGCGTAGTAGG GGTCAAGTAAAATGTGGAAACAGCGTTA AGATCAACTCAGTGAACCAGCCAAGGTA AAAGCAAGTTACCCCTGACTCCACATCTC GGATCACCTAAACCCACGTAGGCAATGG CTGCTACTTCTGCTCTTCTAGGAGGGTC GGGGACTTTGTTCCATTCTAGTAACACAG GTCCTGGAACAGAGACTTAAACGTATGC AAAGCCATTGCTGGAGTTTCAGCAGAGA AATGAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs440431 21 42905781 ATTCAGAC I I I I I GGTTAGTCTGTGCTCA C/G AACCTTCTTTTGGCAGATAGCCAGAAACT SEQ_0806 AGCATCCAAAC I I I I IAAAAAGTTTGACC TTTGAACAAAATACTTAAAAAAAAAAAATA AAATTGTTTTTTCCCACTTGTATTCAAGA CTTGAATACTGATGGGCTAGTGAGATAG GTATAGAACAGCATAACCAGGCTGTCAA CAAAAAACTACTGGGCCAACATGAGGAA AGTGAGAAAATACGAAGCTATGATGTATT GAAGATAAAAATTCAGGCAAATGAACCCA GGTGTCAGAAGAAGATGAGCTA I I I I IAA GCATTTGGGGCAA I I I I I CCTTGGGAGT ATTTCTACTGAGCATGACAGTATAAAGCT G I I I I I I I AGTCATGGAAGAGATGGTTAA TCTCTTTCTAGTAATGGTGAACTAAGCAA GAGGTGGAGCCATATG I ! I I I GCCATTCT TATGGAC GTAGGAATAAAGGACAAAATTTAGCATCT GAGACA rs374651 21 42906042 TTCTCCTGGGGTCCTTCATGCGTGAGGG AfT CAGAATCTTTGGAATGCATCATATTCAGA SEQ_0807

CCCTAGCATGAGAGGGGGCACATTTCTT C I I I I I GGTTAGTCTGTGCTCAAGCATCC

TCTCCTGTAGTTCTCTTTCTATCTGTACC AAACTTTTTAAAAAGTTTGACCAAATTGTT

TGCTGCTTCCATAACACAGAATTTGGGC TTTTCCCACTTGTATTCAAGAGTATAGAA

CACTGCTGTAGCCTCCGTAGCTCAGCCC CAGCATAACCAGGCTGTCAAAGTGAGM

CATGAGGGGTTCCTGTGGGTTGGCCTGT AATACGAAGCTATGATGTATTGGTGTCAG

CAGGCATGGAAACATGCATTCTGAACTC AAGAAGATGAGCTA I I I I I AAATTTCTACT

TAGACAACCCGTGGAC GAGCATGACAGTATAAAGCTTCTCTTTCT AGTAATGGTGAACTAAGCAATATGGACC Ul AACCTTCTTTTGGCAGATAGCCAGAAACT K* TTTGAACAAAATACTTAAAAAAAAAAAATA CTTGAATACTGATGGGCTAGTGAGATAG CAAAAAAC rs380422 21 42906052 G I I I I I I GCTATCTCACTAGCCCATCAGT G/T TGTCTAGAGTTCAGAATGCATGTTTCCAT SEQ_O8O8

ATTCAAGTA I I I I I I I I I I I I AAGTATTTTG GCCTGACAGGCCAACCCACAGGAACCC

TTCAAAAGTTTCTGGCTATCTGCCAAAAG CTCATGGGGCTGAGCTACGGAGGCTACA

AAGGTTGGTCCATATTGCTTAGTTCACCA GCAGTGGCCCAAATTCTGTGTTATGGAA

TTACTAGAAAGAGAAGCTTTATACTGTCA GCAGCAGGTACAGATAGAAAGAGAACTA

TGCTCAGTAGAAATTTAAAAATAGCTCAT CAGGAGAAAGAAATGTGCCCCCTCTCAT

CTTCTTCTGACACCAATACATCATAGCTT GCTAGGGCCCTCACGCATGAAGGACCC

CGTATTTTCTCACTTTGACAGCCTGGTTA CAGGAGAA

TGCTGTTCTATACTCTTGAATACAAGTGG

GAAAAAACAATTTGGTCAAACTTTTTAAA

AAGTTTGGATGCTTGAGCACAGACTAAC

CAAAAAGTCTGAATATGATGCATTCCAAA

GATTCTGAGTCCACGGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs375694 21 42907029 CATGCTCCCAAATCCAACCGTTCCCTCC A/G GAGAGGAAGCCTGAAGGCAAAGTTGGG SEQ_0809

AATAATAAAACCTCAAATTCTCTCCTTGC GAACCGATGTGGAGGCAACAGTTAGAGA

TGGCCACCTCCGTTCAGAGTTGAGGGAG GAAGGTCATTGAGGAGAGGGCACTTCCA

GGAAGAAACTGCAAACTCATACTAATCCC CTGCCGCCTCCCTCAGCGGGGTCCTGC

CTGCCAGTTTGTCTTAGTTTTCAAAGTGA CTTTCCAGCCCCTCTCCCTCCAAATCCCA

CTCTTCTTATAACAGGTGTAACAAGTGAA GGATTCTCTCAGCGCCAGGGCCAGGGAT

TTGATCATTTCGGGCAAGGAAACAGAGC TTACTTCCAGTGGTTCTGGGGGTGTCCA

TGTGG rs384716 21 42907255 GATGATTTAAAGAACAGAAAAAAAGCAGC CfT CTCTGTCAGTTGTGGCTCCTTAATACCAC SEQ_0810

AACGTTGTAGCCTATAAAAATATTTTATTT ATGGACACCCCCAGAACCACTGGAAGTA

ATCTGAGGCAAAAATCTTAAAAATATGAG AATCCCTGGCCCTGGCGCTGAGAGAATC

TCCAGAGACTCCTAGGGTTATGGATGCC CTGGGATTTGGAGGGAGAGGGGCTGGA

TAGTTCCTAAATTCTCATAAATCCTCATAA AAGGCAGGACCCCGCTGAGGGAGGCGG

ATCCAGTAAGTCCCAGGAGCCTCAGGGC CAGTGGAAGTGCCCTCTCCTCAATGACC

AGCCCCCAAGTGCCCCTATCCCATCT TTCTCTCTAACTGTTGCCTCCACATCGGT

TCCC rs9653814 21 42920363 ATGGATGGACCCAGATGCATGGGAAGTC A/G TATACGTGCCATAGGTTCCTAATGAGAAG SEQ_081 1

CTGGGTACATTTCATGCCTTTTCCAGCAA GGTCTTGGACATCACTCTCTCCTCTGTG

TGCAGAGGGGCCAGAGGGGTGCAGCCA GAGTTCAGGTTTCCATTAGAGTTGTACAT £

CACACAGGGGGCCCTCAGCTCCTGGAG TGCTCTCTAGGTCCCTGAAGTCTTCAATC W

TGCTAGCACTTAGCCCACAGGCTGCTCA G I I I I I I GTTTCATTTCATTATCCAGCCTT

CTCCCCAGAGCGCGCTCTCTCTGCTCTC TATTGAAAGGATGCTGTCCAGGATGCCA

TTCTTTAGGTGAATGGTGCCGGCAGAAA GGTCCAGGCTTGGGAGAGGCAGAGCGA

GTTGT rs1888533 21 45825267 TGCCGCCCCAGGAACGCACGCCTGGCA GfT CAGCAATCCCAGTGGGAATCTCTGTCGG SEQ_0812

GGGGGCAAATCCCAGACGGCGAGGACG AGACAGGCCGGTGCCCCACGCCATTCA

GGGCAGGAGGCCCAGCAGCGCTGGGAG GTGAGTGCGAAGCCAGGTGTGAACTGCA

GGTGGGGATGAGCCGGGAGGAGGTGAC GCAGACATGAAGGGAAGGCAGTGACGA

ATTCTCACCTCCCTCGTCAGGCGCCTGC TTGGATTTGAATGTGGGCTCAGAGAAGG CCTTGGGTGAGCAGGGTCAACACGAGGT GGGCGTTGGACCTGCACTGTCTTTCTGG

CACAGCAAAGCCACTGACTGGGCCTCCG

GGGTGATCACCGGCGGCCTGCGCCCAG

ACGGATTTCAGAATTGCTATGGGCTGGT

GGCCACTCGCACCCGTGCCCCTCTTGG

GAGTGGGGAGTGCTATTTGCAGCTACTC

TGTCCCATTGTAGACTAGGGGGATCCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7284964 22 16918242 CTATTACACATGAAGGTATTATGTCATGG A/G TTAGGTAAAGGTCCAAACTATCAGTTTAC SEQ 0813

AAATAACCTATTATTGGCATATGTTTTATA TTCTGGTGTAAACAGGATAATTCACAGAT TTATACATATAATTAAAATAAATATTTTAC TTGCTG I I I I I CCCCAATGGTCTCCAGCT CCCCAAACCACCTTTCTTACATGTGAAGT GGCATGGGTCTTTAATTTATTCACTGCCA ACTCTAATATTTTCTTTCTACTCTGTTTCT GTGACCATTCCCCTCCC I I I I I CCATCCT TTAAAAAAAGATTGCTGGCCACAGTCCTC AGGGAAGAACTAAGTAAACTGCCCTTCTT GAAATCAATTTCGTGACACATTAATGGGT CACGTGCCCCAGCTCCGTAGTCTGAT TGTGATTCTGAGTTTGTAAATAGTTGGTC TGTTTGGACATTGAAGTTACCCACGATGA TGGCAAGACTTGGAATGAAGTGGTGCCA AAGTCTTCAATGAATATGGAGGGGCAGA GGCACAGCTCCATGCATTTGTCCTCGTG AATGGCCTGTGATTTCAGCACAATCT rs 11703744 22 16921221 CTAGAGCATAGAATTCCAGGGCAGAAAG A/G CGTCCAATCACATCTCCCCTCTGCTTTCC SEQ_0814 GGATTCCAGGGGTCTCACACTCACTCCC TAACTGAATGTTGATATTCTCAGCCTATT AACTCTGATTCCAAGGAGACAATCCCCA TTGCTTGTACAAGTCCCGTCTGTCTGCCT CAGTGGAAATCTGTTAAAACACTGAGTAA GCCTGCCTGCCTGCCTGCCTGCCTTCCT ATCAAGATGGTTCCTGCTAATATCTGACT TCCTTCCTTCCTTCCTTCCTTCCTTCCTT AACGTTTTCTTCCAGCTGTACGTTCCCAA CCTTCCTTCCTTCCTTCTTCCTTCCTTCC CCTGCCTGAACGAGGCCTCTAGGACGG TTCCTTCTTTCCTTCCCTCCCTCCCTCCC CA TCCCTCTCTCTTTC I I I I I I I CTTTCGACA GAGTCTCGCTCTGTTGCCCAGGCTGGAG TGCAGTGGCGCAATCTCGGCTCATTGCA AGCTCCGCCTCCTGGGTTCACGCCATTC TCCTGCCTCAGCCTCCTGAGTAGCCTAC AGGCGCCCGCCACCACGCCCAGCTAAAT TTTTGTA I I I I IAGTAGAGACGGGGTTTC ACCATGTTAGCCAGGATGGTCTCAATCT CCTGACCTAACGATCCGCCTGCCTCGGC CTCCCACAGTGCTGGGATTACAGGTGTG AGCCACCGCACCCAG rs 17809578 22 16925566 CAGGCCGCTGGTCCTTTGGTTCGGCAAG C/T CACCATCACTTTCTGAGCTGCTCAGCGT SEQ_0815 CCTGCCAGCAGCACAGCCTCGGGGACG CAGAAAAAGGGTATCTGGCCTCCTGGAA TCTGCTCCTTTTGCAGCAGAGCAGATCTT CTACAACTGTCCCATCATCACACACCTAA CACCTGGGTTTCCTTC TCCTAGGAGAAAGCA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4266108 22 16926041 CACACACCTAATCCTAGGAGAAAGCAGT Crr GAGGGTGCTATTAGGAGGCTTGCCTTCT SEQ_0816

GTTCTGCTGAAGTAACTGCTGGATTTAAA ATTTTCAGCTCTCCATGAGCTAGTTTTGA AAGTGAGATCTTCTAGAAAGATGTATTAA GCAAGGCCTCACTCTTTTCATGGCTCAG AAGATCATGACTTTGGCTGCTGTATTTCA TCTCCCAAACTGTAAAATGGGCATAATTC AAGACCAGGCAGGCATTTAGGTGACAGA TCTCTCTCTTTTCCTGGCTGCCTGATTGT GTTAAATATTCCAAACTTACCTCATCCTC TTGTTGGGTGGAGTAATTAGGCAGCACC TCTCTCTCTGTCTCTCAAGGGTAAACATT CATTCAGTGCTTTGAGTTCATTCTAGAAA CCATTCCTCTTCCAAAACCCAGTGCTTCT AGAGTGCTTTATAAATAACACTTGTTATC CCATATTTGGGAATCTGGAATGGGTACTA TCTAAAGGGGAAAATATTAATGGCCTAGA GGGGCACAGCCCTGTCTCCTCTCGGTGT TACCTCCATAAACTGACACTTTGCCTATA CTGCTGGGAGCTGTAGTCACCAGAGAAT AGTCAAAAAAGATGCCGTGGAATTCCTT GTCGGCTGCTTTTCTCTGGCCAGCAAGC GTATGTGCCTTCCACTCACCCTGGGTTTA AGGCTCTCCTTTCTCAGGAGGACATCTG AATGGTTTCCCTGCATCTCCTTCTATTTT AAAGCAGGAAAGCTGTACACAGTGAGAT GTATCATCTCTAGTTTCATATCCTCAA G rs 10483096 22 16926334 TCTAGAAAAGAGTGCTTTATAAATAACAG AJG AAAAGATGCCGTGGAATTCCTTGTATGTG SEQ_0817

TTGTTATCTCTAAAGGGGAAAATATTAAT CCTTCCACTCACCCTGGGTTTAAATGGTT GGCCTAGATACCTCCATAAACTGACACTT TCCCTGCATCTCCTTCTATTTTGTATCAT TGCCTATAAGTCA CTCTAGTTTCATA Ul rs17742403 22 16928160 TCCATCTCTGTTTTTCTGATCCCTTAGAC MG AGCGATTAGGGGAAGGGTGTGTGGAGT SEQ_0818

TCTGGCTGTCAGAGAGGAGAACTATGAA CTACCTGTAATATATTTCCACTGTCCCGC CTCACCTACTCATTCATGCTGCCCAGGTA TACATTTCAGAACCAGATGCACAAAGAAC ATCACCTCTGTCAT AAACAAGTTTCCCAG rs6000429 22 35546360 TTTGCATGTGTG I I I I I I CTGl I I I I I I I T A/G/T ATTCCTGTGTCGAAGCCCTAACCCCCAG SEQ_0819

CCTTGGAGACAGGGTGCAGTAGCATGAT TACCTCAGAATGGGACTGCATTTGGAGA CATAGCTCACCGCAGCCTTGAATTCCCA CAGGATCTTTACAAAAGTGATTAAATTAA GCCTCATGTGATCCTTCCACCTTGGCCT AATGAGGTGTTGAAAATGGGTCCTAATC CCCAAAGCATTGGGATTACAGGCATGAG CAATATAACTTGTGTCCTTACAAGCAGAG CCACTGCACCCAGCCTCCATGTG I I I I I I GAGATTAGGACACAGACAAGCACGGGAG GGGGACTCCCATCCAGTGCTCTTCCTTG GAGACAGCCATTTACAGTCAAAGAGAGG GCTCTTGGGAGGGCCAGTGGCTGACCC CCTCAGAAGAAAACACCTTGATCTCAGA TTCAGAGCCATTACAACAATCCGTGTGTG CTTCTGGCCTTGAGAAGGGTAAGAGGAT TCCTCTTCAGCATCTGGCTTCTTTGCATC CCATTTCTGTTGTTCAGGCCCGCTCCCA AAAATCAGGCAAGTTCTAATGCTCTGAAC AGCTGGCTAACACACCTGGCGATGGAAA TCTCCCATAGCAAACAGGGAAAATCAAG GAGCCTGCTGAGGGCGCATGAAGGAGA GTCTCACCTCTAACCACTTATCTACACCC GGGTCTCCATTCCCGTGATCACAATGCA CAGTGCTATGGGCTGCCTTTGTTCCCCC GATGCCAGCCCATGTGCTCATGAAAACT CA CTCAAAA rs17810645 22 35546736 GCTCCCAAGCTGGCTAACACACCTGGCG A/C ATGTGCTCATGAAAACTCTCAAAATCCTT SEQ_0820

ATGGAAAGAGCCTGCTGAGGGCGCATGA TGAAACTGTGACATTTCCCTGCTTTAAAA AGGAGAGGGTCTCCATTCCCGTGATCAC AAATGTGATCATAAATATGCCATGTACTC AATGCAGATGCCAGCC TTTAAAGAAACAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID

TS5756357 22 35548173 TAGGACCAAGGTTTGCAGAATGACAATG A/G TTTGTCAATCATTACATTTGACAGATGGG SEQ_0821

GCTGAGAATTGAGAAATAAACACAAACAC AAGCCTGAGGCTCAGAGAGGGCATAAGA

CAATCGAGGCAGAGAGGAAATGAACTGA TGTCCAAGGAAAATGGCAGAGGAGGGAC

GCAGCAGAACTGCCCTCCCCCTTTCCTT TCACCCAGGCCTGTGGATCTGACTTCTG

CCTCCTTCCTCTCCTCCTCCTCCTCCTCC GGCCCTCAAAGGATGGCAGGACATGTCT

CACCGCTATGTCTCTCCTCCTTTGTTCCT AAAGGGATGAGAACAAGGTAGAAGGGAG

TTCCCTTTTGCCTCCTTGTCTTGCCTTTC AGAGAGCAGGAGATGCTGTGTCAACTTT

TTTTCCCTAAGTCTCAATCATGAATGCTT AGACCACAGTGTGAGCTCTACCCTCTCC

GGTCTCACAATTCTACAGGATTAGGGGC TCCTCAACTAGAAAATGTGTACAATACTA

CCTTAGCCACCAATCCAACCGTCTCATTT MTGATGCTCAGTGAAAGAAGCCAGACA

TCTAAAGGTTTTCCCTTGTATTAC I I I I IA CAAAAGGTCACACTACATATATGTATGAA

AATTATGGTAAAAGAAACACACAACATTC ATATCCAGACTAGGTCAATCTAGAGACAA

ACCGTCTTAACCATTTGTAAGTGTAGAAT AAAGCGGGGGCTGGAGGGAAGGAGGAA

TCAGTCCTGTTAGGTATATTCACATT TAGGGAGTAACTGCTTAATGGGCTTTATT

GGAA rs5756363 22 35549989 TGACTCAGCTTAGGCATCACCTCTTCCCA GfT TATTATTATTTGCATTATATTGGTTTTGCT SEQ_0822

GAAGCCCTCCTTGATTTCTTCTCCCTGCT TTTCTCCTAGTTTTGGCCATGTCTGAATA

CACATACCACTCTCATATTGACCTGTGTT TTTTCAAACAATCTCACCAACCATATGAG

TACTGTGATCATTGCTGTGGAGCAATTAT CACTAGAATGGAAAGAATGTCTTGGCTG ^l

CCATGGAACTGTCTTCTCCCAACATGACT TAGGGCAACCTGGTGTCCACTGGGGGT ^

ATGAGCTTGTCGAGCTCAGGGGCCCTTT GCCCAGCTGGTGTGGGGTGGGGGGTGA

CGCAGCAGGGTGGAAAGGAAACTGCGTT GGAGTAGCTGAGGCAGAGAGGAGATGA

GATTTCGGTGCCACATTGACCTGGGTTC GTCCTGGGGGGGTGAGCATTTGGGGTC

AATATCTGGCTCAGCCAACCTGCTAGCT AGTGGTGACTGCTGCTGTTACACAGTGG

CTGTGACCTTGGGACAAATTACTTACTCT AAATGAAAGAATATTCAGTCTCAGCTGCC

TTAGGAACAACAGTTTCACATCTGAAGAA AGCTCTAGCTGTGTGACACTTGCAGAGA

TGAAAATAATATTTTCCTTATGGGGCTGT GACTTGACCTCCCTGAGCTTCCGTTTCC

GCCAAGGAGTCTTGGATGTATTATCACAT ACTTCCGTCAAGTGGGACTCCTGAGAGT

CTCCTGTGAGTCTTTGAACTΠTGTAC CCTCCACTCAAGTGTTGTGAGAGTGAAA

TGAATAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs762919 22 35554708 ATTTTGGGAGGCCGAGGCGGGTGGATC A/G AGGGAACATACAGACCCTAATAAGTAAA SEQ_0823

ATCTGAGGTCAGGAGTTCAAGACCAGCC GAAACTTCCCTAGACCTCAGAGATAGGC

TGGCCAACATGGTGAAACCACGTCTCTA TCATTTTATΠTAAAAATTTAATAGATATG

CTAAAAATAAGAAAATTAGCCGGGTGTG AGATAAAACTAGTATAGTAGAATGGTCAT

GTGGTGTGTGCCTGTAATCACAGCTACA GGCCAATCCACAGCAGTGGGTACATGGT

CGGGAGGCTGAGGCAGGAGGATCACTT GCTCATTTTAAAATTCTTTCAACTTTTCTG

GAACCTGGGAGGTGGAGGTTGCAGTGA TAGGTTTGAAAACTTTCATAATAAAATATT

GCTGAGATCACACCACTGTACTCCAGCC AGAAAGATTTTAAGTTTAAGTTTATGTTTA

TGGGTGACAGAGTGAGACCCAGTCTCAA GAATAATTAATACATTTATATGCTTCAAAA

AAAAGAGAGAGAGAGAGAGAGGACTGTT TTCAAAAGGTACAAGAGTTAAACAGTGAA

TTAAGCCAGGAAGCCACCCCAAGGGATG AAGTCTTCCTCTTGCCTCTTCTCAGCCAC

CTCATGACATATAGGCAAGACAGCCAAC GCGCTTCCCTCCCCAAAGGCAGCCAATG

AGCCCACTCAGATTTACCCTGGGTGTGG TTAGCAGCTTCTGCTGATGGCTTTCCTGA

TAAGTAACAGGGATAATACCCCACATTTC GCAGAATATGTGTGTATACAGC

GCATTTCACA ΓS4821540 22 35566288 ATGCTGAGAATGTTAAGTTAGCTCATTGA A/C TGACTCTCTACCATCTTCTAGTAGTGTGA SEQ_0824

TTAATTCATGTATTAATTCATTTAACCACC CCTTGGACCAGTCACTTACACACTCTTTG

CTATGAGATAGGTACTCCTCTTAGCCCCA CCTTTGTTTCCTTGTCTGTAAAGTGGAAA

TTTTACAGATGACAAAACTGAGCCACAGA CTGAATGAACACACACCTCGCTGGGTAC 'Ji

GGCTATGTAACTTTACTAAAGTCATTCAG TTTATCCAAAAGCCCCTGGAGCAGTGCT ^4

CTGGTAAGTAGGACGCTGGAATTTGAAC GAGCATACAATATTGTTCTGCAACCTTAA

TCAACTAATCTGGATCCAGAGTCTTCCTC CCTGCCCAATCATTCGAATGGGGATAAC

TGATCAAACCTCTCCATTCTTTCTCAGGG TGTTAAGCTTTGCTTGGTACATGGTATGG

ACATCCCTCTTCTCCAGGTGGCTCGCTC TTGTGTGGAACCAGCCACAGACCTGTGA

TGCGGGGGCATGGCCTCACTCTTGTATA TTCTGCC I I I I I I I I I I I I I I I I I I I I I I GA

CTTCCATTGGCCAGAAGCTTATTCCTTAA GAAGGAGTCTCACTCTGTCGCCAGGCTG

AAAGACAGTCTGGATTATTAGAAATTTCT GAGTGCAGTGACACGATCTCGGCTGACT

TTATATTGAGCCTGCATTTCCTTTCCAGT GCAACCTCCGCCTCCCGGGTTCATGCAA

TGCTTTTAGCCCCATTTCTGGGATTTCCC TTCTCCTGCCTCAACCTCCCGAGTAGCT

CTTGAAGACACAGATTAAATTTACATTTC GGGACTACAGTCTCCTGCCACCATGCCT

TTCAAAGCCAACATGAGTCTCTTTCTGAG GGCTAAI I I I I GTA I I I I I AGTAGAGACA

TTCTCTCCTCTTCTCACATTGCCTATGTT GGTTTCACCATGTTGGCCAGGATGGTCT

CAT CGATCTCTTGACCTCGTGATCCGCCCAC

CTCGGCCTCCCAGAGTGCTGGGATTACA

GGTGTGAGCCACCGCACCCAGCCGATTC

TGCTTTCTGTCTGTCTAT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs4821541 22 35566394 TAGCTCATTGATTAATTCATGTATTAATTC C/T GCTGGGTACTTTATCCAAAAGCCCCTGG SEQ_0825

ATTTAACCACCCTATGAGATAGGTACTCC AGCAGTGCTGAGCATACAATATTGTTCTG

TCTTAGCCCCATTTTACAGATGACAAAAC CAACCTTAACCTGCCCAATCATTCGAATG

TGAGCCACAGAGGCTATGTAACTTTACTA GGGATAACTGTTAAGCTTTGCTTGGTACA

AAGTCATTCAGCTGGTAAGTAGGACGCT TGGTATGGTTGTGTGGAACCAGCCACAG

GGAATTTGAACTCAACTAATCTGGATCCA ACCTGTGATTCTGCC I I I I I I I I I I I I I I I

GAGTCTTCCTCTGATCAAACCTCTCCATT I I I I I I I GAGAAGGAGTCTCACTCTGTCG

CTTTCTCAGGGACATCCCTCTTCTCCAG CCAGGCTGGAGTGCAGTGACACGATCTC

GTGGCTCGCTCTGCGGGGGCATGGCCT GGCTGACTGCAACCTCCGCCTCCCGGGT

CACTCTTGTATACTTCCATTGGCCAGAAG TCATGCAATTCTCCTGCCTCAACCTCCCG

CTTATTCCTTAAAAAGACAGTCTGGATTA AGTAGCTGGGACTACAGTCTCCTGCCAC

TTAGAAATTTCTTTATATTGAGCCTGCATT CATGCCTGGCTAA ! I I I I GTA I I I I IAGTA

TCCTTTCCAGTTGCTΠTAGCCCCATTTC GAGACAGGTTTCACCATGTTGGCCAGGA

TGGGATTTCCCCTTGAAGACACAGATTAA TGGTCTCGATCTCTTGACCTCGTGATCC

ATTTACATTTCTTCAAAGCCAACATGAGT GCCCACCTCGGCCTCCCAGAGTGCTGG

CTCTTTCTGAGTTCTCTCCTCTTCTCACA GATTACAGGTGTGAGCCACCGCACCCAG

TTGCCTATGTTCATCTGACTCTCTACCAT CCGATTCTGCTTTCTGTCTGTCTATCTCC

CTTCTAGTAGTGTGACCTTGGACCAGTC ACTGTCCTCCTCCTT

ACTTACACACTCTTTGCCTTTGTTTCCTT wi

GTCTGTAAAGTGGAAACTGAATGAACAC Se

ACACCT rs5756370 22 35566976 AGAAGGAGTCTCACTCTGTCGCCAGGCT CfT TCAGCATCCACGGTGTTCTTGGTAAAACA SEQ_0826

GGAGTGCAGTGACACGATCTCGGCTGAC CAAACCTCACCCAGTATCTCCTCTGTTCA

TGCAACCTCCGCCTCCCGGGTTCATGCA GATCCTTCCCACACCTCTCCTGGCCTGC

ATTCTCCTGCCTCAACCTCCCGAGTAGC CTGATAAAGTTCAAATTCCATGGCTTGAC

TGGGACTACAGTCTCCTGCCACCATGCC TTATAAGGCCCTCCTTGGTCTGTCCGCT

TGGCTAATTTTTGTATTTTTAGTAGAGAC GCTGATCTCCTGGCCTCTCCTCTCCTGTT

AGGTTTCACCATGTTGGCCAGGATGGTC TCTCCCCTCCTGCTTCATCTTGAGCCAAA

TCGATCTCTTGACCTCGTGATCCGCCCA CGAACCAGCTCCTGGGTCTCTGAGCCTT

CCTCGGCCTCCCAGAGTGCTGGGATTAC GCCTGACTTTGTGCTGTACCTGCTTTGTG

AGGTGTGAGCCACCGCACCCAGCCGATT TCTGAATCCCCAGGGCCTAGCACTGTGC

CTGCTTTCTGTCTGTCTATCTCCACTGTC CTGGCAACCATCCGGGGCTCCGTAAACC

CTCCTCCTTAGACCCTATCAGCCCTGCC TTGGCTGGTGTGTGATGCCGAGAAGCGA

CTGAGCTCACCCTCAGCCCAATGACCAG ATGCTCTGTAAGCCACTGCTGCATCCGT

CTTCTAGTCTTGCTCAGCTGCAACCTCTC GGCAGTTCATGCCATGAI I I I I I CCAGG

TTCCC GG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs2269513 22 35568084 CAGCCCTCTCAGAAGGCTTTTATTTTGAA CH^" GGAATCCCCTCTCCTATGTGGCTGTTGC SEQ_0827

GCCTGCATAGGGCCTTTGGTGACCTGTT TTCATG I I I I I I CATGGCACCCAATGGGT

TTCCCCAGAGTTTGCCCACAGGGCTTGG TAGCTTGTTGGTTGCTCATGTAGTCCGTA

AAAGCCTCTTTTACCACATGGCACTGTGC GAAAGCCATCTTTGAATAGGTGACAAAGT

ACACCAATCTGGCCTGGTTCTTTTTGCCT TTGAAATGTCTGCAAGGGAACCAGCAGA

AAAGATCCCTCATCCCCAGGACCTCCAT AAGTGGTTGAGGTGACCCTTCCATGGGG

TTTCAGGATGGGGACATGGAACACGGAG GGAGTCTCTCTACAAGGGTGTATCCGTG

CCCATGGCATATACCAAACAAACAACATT TGGAGCTTTGGCAGTTCCGAGCCTCCGT

GAATGGCATGTAAAACAGTGGTTCACCA TCCCTCCTGTATGACATGGAAGCTGTTG

CATGACACCTTCATTCAAATGGGCTTGCA CCACCAGCAGCACTGCATGGGCAAAGG

GATTGGCTTAGCCTGTGAGAGGACAGGT GAAAGTACCTGGCCAGCCCAAGGTCCCT

GTAGGACTGACAGCCCTCGACAGATGGG TCTCCTGGGTTCTCATCAGGTTCCAGTGT

AGCCAGGTGACCTCCACCAGGGGTCTTC CCCAGGCCATGTGATGGAGGCGAAGCTA

ATCCGTCAGGTAGGACCAGCATCTCCAA GGGCACCCTCTGGAATGAGAAGCATGAA

GTG ACTCA rs2269515 22 35568739 GCCACCAGCAGCACTGCATGGGCAAAG A/T GTTGCACATACAGAAAGCAATCAACTACT SEQ_0828

GGAAAGTACCTGGCCAGCCCAAGGTCCC TTGTGGAAAAAAGTTACAAGCATTGGTCT

TTCTCCTGGGTTCTCATCAGGTTCCAGTG CTCCTCCCTCCTGAGCCCTTGTTGACATA

TCCCAGGCCATGTGATGGAGGCGAAGCT GAAAGAAAAAATATCTATATCTATATCTAT ui

AGGGCACCCTCTGGAATGAGAAGCATGA CTATCATCTATCTATCTCTATATGTATATG S

AACTCAAGTCCCAGCTCATCTCTGTGAC TATGTATGTGTATATAAAGGATAGTCCGT

GTCCAGCAATTCATTCCCTCCAAGCTCCA CAGTCAAGGACAAAGAGAAGAGAAAGAG

GTTTCCTCATCTGTGGGAGGAATACTGTA CATCAATGGATGTGAGATGGTAATACACT

AAGAAAAGAAAAAAATACATATTGCAAAC GTGGAAGGCGGGATTTGCTTCGAGGAAA

TTTCAAAAGTGAAATGCTTATTCTGGTGC GGTAATATATTCAGAAGGGCAGCAAACC

ATTCCTGGGGGAGAAGGGAGCAGATGA TACACAATGGTCAGGTGTGGTGGCTCAG

CTTCCAAGTTCAGGAAAATACCTTGATTC GCCTGTAATCCCAGCACTCTGGGAGGCC

ATTTTGGTGTTG I I I I I GCTGAAAAGGAG CAGGCGGGTGGATCACCTGAGGTCGGG

AGGCCTTCTGGGAAAAGTCTGGATAAAA AGTTTGAGACCAGCCTGACCAACATGGA

GAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 10211998 22 35569377 TATGTATATGTATGTATGTGTATATAAAG A/G CCAGTGAAAAGAAAACCAATGAGCTCAG SEQ_0829

GATAGTCCGTCAGTCAAGGACAAAGAGA ACCCGCCCCCGCCCCCCACCCCCCCGC AGAGAAAGAGCATCAATGGATGTGAGAT CACAGGGTCCCCAAGGTGAGGGGAGCA GGTAATACACTGTGGAAGGCGGGATTTG GGTGGAGAGGACGACGGGGGTGCAGTG CTTCGAGGAAAGGTAATATATTCAGAAG AGAGCCAGCAGCCCGGGGCTTATCCTTG GGCAGCAAACCTACACAATGGTCAGGTG AGCCTTCTTCGGGAAGTCGATTCTCTGA TGGTGGCTCAGGCCTGTAATCCCAGCAC GGATGGCAGAGAGGAGAGTCTCAGGAC TCTGGGAGGCCCAGGCGGGTGGATCAC ACCACGGC CTGAGGTCGGGAGTTTGAGACCAGCCTG ACCAACATGGAGAAACCCCGTCTCTACT GAAAATACAAAATTAGCTGGGTGTGGTG GTGCGTGCCTGTAATTCCAGCTACTCAG GGGGCTGAGGCAGGAGAATCGCTTGAA CCCGGGAGGTGGAGGTTGCAGTGAGCC GAGATCGTGCCATTACACTCTAGCCTGA GCAATAAGAGCAAAACTCTGTCTCAAAAA AAAAAAAGAAAGAAAGAAAAGAAAAAGAA AACCTACATTACGCAGAGCGGAGC

K* rs5756371 22 35569520 ACCAGCCTGACCAACATGGAGAAACCCC Crr CTTCGGGAAGTCGATTCTCTGAGGATGG SEQ_0830 O

GTCTCTACTGAAAATACAAAATTAGCTGG CAGAGAGGAGAGTCTCAGGACACCACG GTGTGGTGGTGCGTGCCTGTAATTCCAG GCCACCAGCATAGCGGAGGCCTATGAGT CTACTCAGGGGGCTGAGGCAGGAGAAT GCCCTACGGAGGGGCATGTGCAGAGCC CGCTTGAACCCGGGAGGTGGAGGTTGC CCTCATCCCCTGGTCATCCCTACACCTTC AGTGAGCCGAGATCGTGCCATTACACTC TGCCCTTCCGTTAGAGTCTGTAGATAGG TAGCCTGAGCAATAAGAGCAAAACTCTG GTTTTCGGGGGATAAGGGGCAGGTCCAC TCTCAAAAAAAAAAAAGAAAGAAAGAAAA GCCCTACAATGCAGGGCTCCGGGAGGT GAAAAAGAAAACCTACATTACGCAGAGC AGGGGTTTCAGATGGGAGTGTGTGGGG GGAGCACCAGTGAAAAGAAAACCAATGA GCAGAGGAACAAGGGGAGAAAAGACCC GCTCAGACCCGCCCCCGCCCCCCACCC TTTCCCTCCCTCATCAGAGAAGAAGAAG CCCCGCCACAGGGTCCCCAAGGTGAGG ACTTTTGGAAAGACCTGGGAGGGGTGCT GGAGCAGGTGGAGAGGACGACGGGGGT GGAGAAAGTCTAGATCCTGCTATTAAGT GCAGTGAGAGCCAGCAGCCCGGGGCTT GGAAGGGGAAGTGGTCTGAGCATCAAAC ATCCTTGAGCCT TTTACCCTGAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11913594 22 35570829 ACCCGCAGGACGGATGGAGGACAAGAC C/T TGGGGAAGGTGGCTGAGGTTGGAGAGG SEQ_0831

CAGGTGGGCCACTGTTGAAATTATTCAG CATCTGGGAGGAGCCCCAGTCACAGAG

GCAGGAGAGGAGGAAAATCTGAATTTAA GAGAAGCGGTGGGAGCAAGTGGCACAG

GCCCAGGCTGTAGGGATGGAGGAGGAG GGGTTGGGGGAGCCGAGGCAGCATTGT

AGGCAGTTAGAGGGAACTTAAGGAGGTG GGGTGGTAGGTAATAGCAGAGGCCAGG

AAATACATTCCTGACAGATCGGCTGTGG CCAGGCGCAGTGGCCCACGCCTGTAATC

CAGGCCAAGGAGACAGGAAGGCCAAGG CCAGCACTTTGGGAGGCCAAGGCGGGT

TGACTCCAGGTTTCTGTCTTCCGTAAATG GGATCACCTGAGGTCAGGGGTTCAAGAC

GTGGAGACAGAGCTCAGGAGGAGGGGC TAGCCTGGCCAACATGGTGAAACCCCGT

CGCTGTGGAGGGAAAGGAACCACTGGC CTCTACTAAAAATACAAAAATTAGCCGGG

TTGGAGGGGCTCGGGGAACAGCTAGGG CGTGGTGGTCCACGCCTGTAATCCCAGT

AGAGGTAGGGGGTCCAGGAGGCAGCTG GACTCAGGAGGCTGAGGCAGGAGAATC

GGACACACGGCCTGGTGCCCAGCGAGC ACTTGAATCCGGGAGGCAGATTGCAGTG

GACCGCAGAGTCCTCGGTGTGCAGATG AGCCAAGACTGCGCTACTGCATTCCAGC

GTAACAGAGCGCTCGGGAGTAAGGAAAC CTGGGAGACAGAGTGAGACTCCGTCTCA

CCCCACTCAGAGTGCATG GAAAAAACAAAAACAAAAAACAAATAGCA

GAGGCCACAGCTGCAGAAGGACCCCAG

GTGAGGGCTGGGGACAGGAGTACACTG

AGG 8 rs910923 22 44808421 AGAGGCTTCTCCCATTGTGAACGGCCAC C/T ATGCCTGAGGCAGCCAATTCCACACCTG SEQ_0832 ^

ACGAGAGTCCGGCAGGTCATGTTATCAC AACCCTCAGAACCCTCTAGAGATCCACT

AACTCCTCAATTCAAACGCCCAACCCCA ACATGTCAGAAGTGGGGGTCAGAGAGAC

GGAGCACGGCTGGTGCGTCGAGCTTTC TGTGGGAAGCTGAGGCTCAGAGCCGGG

CACATTTAAAGAGGCACTGCATGAACATC GAGGGGCTGGCCCAAGATCACACGGCC

TCTGCAATAAATCTCTCCTCTGTCCTCCA GAGTGGGACCCAGGCCCTGCTCACTGG

GGTGGGATCCCAGGTTGAAGCCCAGGA TCAGCCGTGAGCTTCCCAAGACGCACTT

ATGTTTT GAAAGGCCTTCCCCGAGCTGCCTCGGG

CCCTCTGGACAAAGATGCCAGGCCCCAG

GAGGATGTGTGGCATCTACACACTTGTT

CATTGCACCCGAGAAGGTGGAACGTGGA

AAGACGAGGCCATGGTAGCTTCGACGGT

TCCTTCCGGAGGGACCAGATGGGCCA rs9616111 22 44810871 TGGGCAGGGGCAGGGAAGGGGCTAGGA A/G ATGGGCCACGATCTGTGAAAATGGCCTA SEQ_0833

TGGGGCTGGGGATCGGCCTCTGGGGCA AGCTGGCCCTGTCCTGGGGGCCACACA

TTGTTCCCAGCCCCGTGTTCACTCTAATG GGGGTCCTGCAAGGAAGCACACCTCGG

GGTTTAGCACCAGCCTC GGTGTGGGCTCAGAGCAG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11702999 22 44811345 GGTGCTGCTTGATGGGGCTCCTGTGTCT A/G GGCTGCTCAGTCTCTCTCCACTTGCCAC SEQ_0834

CCAAGCCGGGGAGCTGAAGCTCCCAGG TGGGGGAACAGGCTTGTCCCGTCTCCCC

GCTACACCTGCCCCAAAGCTGGTGCCCA TCCCCTCCCCTGGCTCCTGTAACCTGGA

CTCACTTGTGAGGGCAGAAATCCCACAT AGTCAGACTTTTGATGCTAACCTGGGTTC

CTCTGGTACATCCAGGGCAGACGGGAG GAGATACATTAAATTGGGCTAGCTACAAA

GTGGCCTGTGGGGCTGGGCCCTCGGCA AAAGTGGGCCTCCGTGGCTGGGCCTGC

GCTGCCCTGGCGCAGGGGGGTTCGGGC CCTGGTGGCAGCCCTGTGAACCTGAGC

CCCACTAA GGGG rs13058684 22 44811530 TTCGGGCCCCACTAAAGGCTGCTCAGTC C/G TGAACCTGAGCGGGGGCATGCCATGCC SEQ_0835

TCTCTCCACTTGCCACTGGGGGAACAGG AGTCCCCATGCTGTCTGGGGAGCTCCAG

CTTGTCCCGTCTCCCCTCCCCTCCCCTG TCTGTGGTACTTTTCCTGGGGGGCCCCA

GCTCCTGTAACCTGGAAGTCAGACTTTT GAACTCCTGTCTTGTCTGCTCCAGGTGA

GATGCTAACCTGGGTTCGAGATACATTAA GGGCATTGGGGTGGTCCCAGCCAGCCC

ATTGGGCTAGCTACAAAAAAGTGGGCCT AGGGCGGCAGGTGAGGGCATTGGGGTG

CCGTGGCTGGGCCTGCCCTGGTGGCAG GTCCCAGCCAGCCCAGGGCGGCAGGTG

CCCT AGGGCATT rs6008955 22 44814558 TGTCTCCCAGGAAAGTTCTTAACCTCAG A/G GTCCTCGAGGGGCTCAGCCTGACCCTGA SEQ_0836

GCCTCGCCGGGTTGGGCCCACCTGCAG CAGGTAGAAGAGACCCCACTCCAGGCCC

GAAGTTGTGAGGGGTCCCTGAGGGGTG AGAAGTGAGGGAGTAGAGCAAAGGGTC ^n

GAGGGAGAGGCCACCTTCACTCCCTCCC CCTGGCCTACTGTGTGACCACTACCTGC W

CAGTCTTCAGCCACCAGACCTCCTGAGC CGCCCTGCCCAGTGGGACAGGGATGCC

TGACTTCCTGGTCTCCTTGTGTCTTGCAG CCGCACCCAGCCTCCTCACCATCCAGGT

AATGTGGCCCCGTCCCAGAGCACCACCC GGCCTGGGGGCACCCAAGGCTTCGGGC

GAGACATCAGGAGCCCATCGTGGGCTAG AGCCCCTGAGCTGGGCCCAGGTCTCATG

GGAAGATCCTCCGGGACCTAACGGCCCA GCGGTCTCAGGGCAGGCAGGGTGAGAG

GGTAGCTGCGTCTTTACTCCCCGCCTGG CTGACAGGGAACAGATGAGGGAAGAGC

GCAGGGAAGGACTCACTCCAGTCACAAG ACCCCACACACCCGGGGGTTCCACCATA

CAGCCTGGAGATGGATGGTTTGGCAGAG AGACTTCCTCAGCGTTTCTCTTTCCTTCC

AAGGGGAAACCCCAGCACCAACCCAGC AGGTCTTCCACCCTTGGCCACCTCCCCA

CCCAGGCCCCACCTTGCAGCCAGGTCTG GGTGATGCCTGAAGCTCAAGGGACTGTG

CCCTGCCCAG TCCACCCTCAGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs873492 22 44818409 GAACAGCGACACGAGGCTGCGGGATGA G/T CCCACAGGAACTCCTAACAAATCTGAAC SEQ_0837

ACTGGGAGCCTGCTCCTTCCCAGAGCTG CGAATCAAGAAGGTGTTTCACCCAGGTG GACATGGCAGTGCTTTCAGCTCACTACT AAACCTGCAACAGCAGGTGGCTGTCCTT GTGTGGGGAGCAAGGCCCCCAGCCTGG GCACCCTGTCCCATCCCTCATCACGGTG GCCATGCCTGAGGCCAGGTGCCCAACC AGGGCTCAACTTCATGCTCACTAAAGTTT AACCAGGCCAGGGAGGGAAGCCAGAGC CTCCCAGACAGAGAGTGCTGCTCAAAGC TGAGGAGGCAGCAGCCTTGGCCACTGC CACCAGGGAGTGCCGCGTGAGGGCCAT CAGGAGCACTGGGGCTGGGGGCCTGGC CACTCTGCATTTTGTCCATAAAGACAGCC CCACCCCGGCACCATCCCGGCAAGGGT CCCGACTACCAGGATCCAACTTAAGATT CTGAGTGGCAGGGCCTGAACCCACTGCA CTCAACCCAAAGGGTATGAATTCAGTAG CAGCCAGACTTCGGAAGGCTCGGCCCA AACCAACCCACT GACCCCAGACCTTCCCCGCCCCTGAGG GATCTGGTGGCCCCACACCTTGGCGAGA CAACGTTCATGGAACCCAGAGGTGTTTC TACTGCGGGGCAGCTTGGGGCCAGGGC CCTGCTCTGCTGTATGCCAGCCTGGTGG CCAGGGCAAGCCCCGTGGGCTCTGGGA GCCTCAGGGGAGGGGCACTCAGCAGGG CCATCAGGAAGAGGGATGACTCCATGTG Ul ACTGGCTCAGGGCTTG rs6007640 22 44819953 AGGCTTTTCCCTAATTTCATTCTTGTTTTT A/G GGTGCTGCCTGCCAGGCTCTACTCTGCA SEQ_0838

TGATGAAGGCCCTGCCCGTGGCTCTGGA TCCAGCGAGTGTTTGTTGGGGGCAATGG TCGGCGGTCCCCATCAGAGGCCTGGGC GGCCCGTGCCTTTTGTCCAGAGGAGGCC TGAGTCCTCAGGTGTGTGAGTACCATCT GGAGAAGGGGACACAAGAGGGGAGTGG TCCCCTGACCCGGCGGCCCCACAAACAC ACAGACGGTCACCAGGCAGATAAGCAGG CCCTCTGCCAGCCACAGCTCGGCCGCC ACGGGGCTCGGGGCTTGTTTGGGAAGT CTGGGCCTTGGCCTCCCAGTCTGTGCAG GGCTGGTGCTGAGCTTGGCTGGGGCAG TGGGGTTGGTGACGATCACAGGCTTCTG GGCTCCAGGAGGGGCCGAGTGGGCCCC CTCTGTGCAGGTCGGGAGGGAGTGCCA ACCCCCGACCCTTGTCGGCAGGGCCCC TGTGGCTGCACCCCCAGCCCAAGAGCA GAAAGTTCCACGCTGTTGGGGGGGTGC GCCTCGCTGCTGGACCTTTGGGTTCCCA CGTGGAAGGTGGAGCGGGGAGCAGCCT ATAAGATCTGGTGAAGACACATGGAGAC CCGATCCCTGGAGCAGGTTCCCCAGCGT CACTGCTGGGCGGGGGCAGGAAGGCGT TCCCGTGGCAGCCACTTCATGGCACAGT CCCTGTGGCACCCTGGGGCCGCCCATC GGTCCCCGGAGTTCAGGCCAGGCCCTC TGTTGGATCTGG GAGCCGCCTGTCTGGG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs910360 22 44822824 AGGCTCCTCCCCCGGCCCTGCACACTGC A/G πGTGGCCACAGGTGTCAGCGTGGAAGC SEQ_0839

ACGCAGGTGGGAAGGGGGTGCCCCCAG TCACAAGAGTAACGCAGCACCCGAGACA

GATGGAGCGTGGCCCGGACCCCAGGGC CCTGAGGGCTGGCACTGGCAGGGGAGG

TGCCTTCCTTCCAGGGCTGCCTTCCTTC ACCCTGCTCTGCAGACACACCTGCGTCC

CAGGGCTGTCTGGGGTCCCAAGGTCCC ATGGGGCACAGCCCTGGGGGCTGCCAG

CTCACTGGCCCTCCTGTTAGCACCCTCC GCTTGGTTCTGACCTGCTCTGTCTCCCT

CTGTCTGGCTTCCCCAAAACTGACACCC CAGTGATGGGCCTGGGATGGGGTAGGT

ACGTGCTCCGGGTCAGGGTCTCCACCGT T

CGGGGGTCTGTGCCCTGTCTAGCTTCCT

GCTTTCCTGTTCTCTCATAGCCACTAAGT

TCTCAGTGGGGGTGGGGGGCAGGCTCA

GGGAATGTCCACTCCCTGGGGCAGGGG

CCAGGCCTGCTGTGGCCACATGTCCTGC

ACCTAGAACAGGGCCAGAGGTCCAGCA

GACACCAAC rs3859891 22 44824287 AGCCTCCCAGAGCAGCAAGTGTCCCGG G/T GGGTGTGGGGTGGGGAAAGACTGATGT SEQ_0840

GCAGGCCTCTGCTCCCAGCATTGCCCTG TTCAGCTTCGTGACCCACTCATGGAGCC

GCCTGTCCCTCTGCCAGGCACAACCACC ATTTCTGAGCTGGTGGGGAGAAGGCCAG

CTGC I I I I I CCTGCTCCTTTCCCCTGAGG TTGCACGTGTTGTGGGGTGTGTGCGGG $

GCCCTGTGTTCCCTGGTGAGTCCCAGCT GGTGATCTCCAGGCCCACCTACCTGGCA *-

CTGCCCGCAAGGCTCTAGGACTCGCATC GCCCTGGGGGTGAGCATGGGGCTCAGG

TGGACCACCCAGGCCTGCAGTGGTCAG CCTGGGGAGACAGCAGGAATCTCCCCTT

GGAGCCTGAATGTGGCAGTGCCCGCTC TCTCAGGAGGCTTCCTGAGACAGACCAG

CGGGGGACTCTGAGGAGGGTGTATGGA AGAAACCCTTCGCAGCCAGCCTGGATGA

CACATTTCCTGCACACCCAACCCTGCTG GGGCTGGGAGGGCCATGCAGCGTAAAC

TGCTCCACAGGACCAGGACACAGATGCT GGTGCTCCTTGAGCAGAGCTGACGGGG

GTGACCTCAGCGGGCTCCACCCCCACC AGTGAGCAGTCGGCAGGCGCTCTGCCAT

GCAGGAGGATCTGCACGCAATCAGGAGA CTGCCAGCTGCCACCTCCCGGGCGCTG

ACTCCAGCCGACAACCAGGGCTTTCT CCCCGGCCCCACGGTGTCTGCCCGTGG

GCAGGGTGCCCGGCAGGCCCAGGCGG GGGAGGGGCCGGGCCAGCCAGGACAG

GTGTGCGGAGGCCTCGGTGGGCAGGTG

GCCATTTCAGGGCCGGGCGGATGTCTG

GAGCAAGT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs11090910 22 44828189 AGACCTTTCAAGTCCACTTGGGCATGGG C/T CTGCCCCCTCAGCTTTTCCCCAGGAAGG SEQ_0841 GAGCTGAGAGCTAGCATGCCGTTTAACT ^' TGGTAGCCACAATTAGCATTTGTTGAGG

TGGCAGGAAGCAGGCCGGGCGCAGTGG CTGACCCTGCACCAGGCCCAGGATAGG

CTCATGCCTGTAATCCCAGCACTTTGGG CGGGGCTTAGGGAGGCCCGTCTCTCGC

AGGCTGAGGCGGGCGGATCACGAGGTC CACGTTCCCCTGCTAGGGGAGCCCCGA

AGGAGATCAACACCATCCTGGCTAACAC GGCCCTCTCAGTGTCATCCTCATGCTAC

GGTGAAACCCCCTGTCTACTAAAAATACA ACTCTGTCCCAGCCCTGTGCGTCCCAAG

AAAAATCAGCCGGGCGTAGTGGCGGGC CTAGGGCACTGAGT

GCCTGTAGTCCCAGCTACTCGGGAGGCT GAGGCAGGAGAATGGCGTGAACCCAGG AGGCGGAGCTTGCAGTGAGCCGAGATC GCGCCACTGCACTCCAGCCTGGGGGAC AGAGTGAGACTCCATCTCAAAAAAAAAAA AAAAAAAAAAAAAAAAAGCTTGGCAGGG AGCAGGACATTTGGACCTCACTCTGCTG CCCCCTTGGCTGTGTGACATCCAGGTCA CGTTGCCTCTCTGGGCCTCGGTCTCCTC ACCTGTTTAAGAGGGGTTGACAGTCGTA

Ul K> rs7288847 22 44829702 GCCCCAGCCGCACTGAGAGAGGCGATC C/T GTTGCCCATCACCCCAGGTTCCCAGCAC SEQ_0842 CACGCAGCTGTTTGTCTGACCTCTGTCT GTGCCCCAGCCTGGCCAGCTCAGTGGC CCCAACACTCCCCAACACTCCCCCCGCC AGGGCCTCTGCCTGTGGAGGAAGGGAG ATCAGGCCCAGGCTCATGGGTGGCCCT GCCAAGGCACCTTTCCTGAGCAGGAAGT GAGCCGTACCCTCCACTGAGCACCAGGA GAGAGGAACAGCTCTGCATACACTGGGT GAAGGCACCGTGGGGCCAGGGGTGGCC CCCACATGGCACAATCTGAAGGCAGACA GAGACGTTTGGAGGTCACAGGGCTGCG GTGGCTCCTCTGTACCTGGGGAAACTGA AGTATTGG GGCCCA rs6007862 22 44832287 ACCCCACTTCCCTCCCTACCCTCCAGCT A/G CCCTACAGAAGAAAGGTCGGCGTGGCC SEQ_0843 GACCAAAACCTTCCCTGCTGACTGGCCG CTGTCCTCCGAGGAGATGAGGGCTCAGA TCCCTAGAGATGGGGTTGCCAAAACTCG GAGACTCGAGGGGGCTCCTGGGCTGTC CCCAAAATATAGGATGAGGGCAGCCTGT CAGAGTGGGCCCTTTGAGAGACCCCTGG GGAAGTTCTGGGGGTGACAGGCCTAGAT GCCCTAAGGTTCAAGTAGGCCACCGCTG TGGTCACTCTGCTCACCAAACCTGTTTCC ACCTTGGCCTTCCTAGGAGGGATGCAAA CATCTCGCAGTGGGGTCACCGTAGCTTC GCCAGCCCACCACTTGAACCCGGCAGC CACCTCCCAGGGCGCCCATGAGGATTTA CTGAGCACCGAGGGACAGGGCCGCCAT AGCTGATACCAGATCAGAGTGCCCAGGG CCAGGGCCAGGGCTAGGACAAGGCCAG ATGTGGATGAGTTGCCTTGAGAACAAAG CAAGGTGGCAGACACGGAGCATCTCGG TCCAGGGAGGAAAGCCGGGGACCAAGG CCGGGGGGCCTTTCTTGGGTCACACATC ACCTTCAGGATGGCCCCAGCTTCCCGGG AGCACGGGGCACAGAGGTGAGAGCCCA CTGTGCGGGAGCCACGTGCCACGGACC GAAAGAGTCTTGTTTCCATTTCTTTTAAAA CCTCCCAGCTCAGGCAGTACCGCCAGAG CGGGAAGGGAAAATGACCCCTCCAATAC CACAGCCTT TGAATATATAATG

Supplementary Table 3

SNP Chr Position S' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1635209 X 3209321 AGAGGTTAAGATGATGGAATGTAGAGCA A/G ACAGAAGGCTTCCAAGGTCATACGTTGG SEQ_0844

GAAACTTCCTAGGTTCTGAAGTTCTCATA CAGGTAGAGTTGATGGAGAATTTTGCTG GAACAGAAGAGTAACATGAATATAAAGCA GAAGCTGGAGATTGAAGCAAGAGGAGG CAGACTTTCTAGATTTAAACTTCTCATTAA CACATTGCAACCCAGTCGCTATGAGAAC GAAGGTAGGAAGATGGAATAGTAATTGT AATTATTCACCTTTCTCCCGCTGAAGCAC ACCATCTTAGAACTGAATGACCAAAGGC CTCAGAATAAGAAGTAACTATGGGCTTTC AAGCTGTTCAAACTCACTGTGCCTCAACT CGTAGTCTTTGGGAGAGTACCAAAATCAT TCCTACTATGTAAAATGGGAGCAGTGGT TCTACCGGCATGTTTAAGTGAAGGGCAG ATTGGCACCAACTTTGCAGGGTGGTTGT AGGGAGGACCTGAGTCATTTGGGTGACA GATAATCAAATAAGTAATATATGGAAACT TATATMCGAACAAAGGCAGΓΓTTTGAGA GGCCAAGACTGTCAAGACTCTACATAGA ATTCTAGAGGCAGTAAAAGTTAGGAATGT TACCAATTATTATCATCAGTATTGAATTTG AGGAGAAAGTGGTATAACAGGGAATATT GAAGATGAAGGAGAGAAGATGAATTTGA AGTTTTTACATCACCATCATAGAAAAGTC GATTGGGACAAATTTAGCCAGTCATTGA AAAGGCCATAAATGTGTGAAGGGATAAA

GAC rs2694708 X 3209583 TCAAATAAGTAATATATGGAAACTGGCCA C/T GAACAAAGGCAG I I I I I GAGAATTCTAGA SEQ_0845

AGACTGTCAAGACTCTACATAGATACCAA GGCAGTAAAAGTTAGGAATGTAGGAGAA TTATTATCATCAGTATTGAATTTGGAAGAT AGTGGTATAACAGGGAATATTAG I I I I IA GAAGGAGAGAAGATGAATTTGAGATTGG CATCACCATCATAGAAAAGTCAAAGGCC K*

GACAAATTTAGCCAGTCATTGAAACAGAA ATAAATGTGTGAAGGGATAAAGACAGGA

GGCTTCCAAGGTCATACGTTGGCAGGTA GATAGAAAATGATACACCTGAGAGTTATA

GAGTTGATGGAGAATΠTGCTGGAAGCT CACATAGCTGCTCACCGAGCCTGGAAGA

GGAGATTGAAGCAAGAGGAGGCACATTG CCCTCCCCATACCCAGCTTCTGAAAAAAA

CAACCCAGTCGCTATGAGAACAATTATTC TATATTAATAAAATAAACTTTCAAAAAAAG

ACCTTTCTCCCGCTGAAGCACCTCAGAA AAAATTAACCAGTACCATTATTΠTACATT

TAAGAAGTAACTATGGGCTTTCCGTAGTC TATCAACAACTGATAATTCTCATCTAATTG

TTTGGGAGAGTACCAAAATCATTCTACCG TTTTCATAATCTTTGTCCTTTGTACATACA

GCATGTTTAAGTGAAGGGCAGAGGGAGG TCATTTGATGCTTATCTTATCATGTTACAA

ACCTGAGTCATTTGGGTGACATATATAA TTAATGTCTGAATCTACAACTT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs764302 X 3209687 ATTTGAGATTGGGACAAATTTAGCCAGTC A/G GTCAAAGGCCATAAATGTGTGAAGGGAT SEQ_0846

ATTGAAACAGAAGGCTTCCAAGGTCATA AAAGACAGGAGATAGAAAATGATACACC CGTTGGCAGGTAGAGTTGATGGAGAATT TGAGAGTTATACACATAGCTGCTCACCG TTGCTGGAAGCTGGAGATTGAAGCAAGA AGCCTGGAAGACCCTCCCCATACCCAGC GGAGGCACATTGCAACCCAGTCGCTATG TTCTGAAAAAAATATATTAATAAAATAAAC AGAACAATTATTCACCTTTCTCCCGCTGA TTTCAAAAAAAGAAAATTAACCAGTACCA AGCACCTCAGAATAAGAAGTAACTATGG TTA I I I I I ACATTTATCAACAACTGATAAT GCTTTCCGTAGTCTTTGGGAGAGTACCA TCTCATCTAATTGTΠTCATAATCTTTGTC AAATCATTCTACCGGCATGTTTAAGTGAA CTTTGTACATACATCATTTGATGCTTATCT GGGCAGAGGGAGGACCTGAGTCATTTG TATCATGTTACAATTAATGTCTGAATCTAC GGTGACATATATAACGAACAAAGGCAGT AACTTGTGTTGTAAGTTCACTGGGATACA TTTTGAGAATTCTAGAGGCAGTAAAAGTT GGAATCCCATGCAATTCACTTTTCATTTC AGGAATGTAGGAGAAAGTGGTATAACAG ACTGTCTGACTCAGTGCTTTTCCCATGCT GGAATATTAG I I I I I ACATCACCATCATA ATGTCTCAGTAAATGTTGACTG GAAA rs1625354 X 3214032 CCACCATTCCACCTGTTACACCAGACTCT C/G CACTCTTGGGAGAGTTGAATTCTGAAGA SEQ_0847

GACCTACAAATCAGAATCTCTCAGTGAGA AGCATGCTTAGATATGACCACTGTAATAG AGCCTGGGTGAGTACAAAGTGCAGCAAG TGTAGGATAGGAGCACTGGTATAGGTCC Ul AATGTGATGAGGAAGTGGCATCTTTAGC AATCCTACACCATCCAACTTCAGCTGCAG K> ACTGGAACTCATTTGTTCCTGAAGTGGTC CTTATGCATCCTAAGCCATGTAGCAGAAC TGGCAAAACTATACTGTGATCCATCACAT CAAAACTAGAAACCAAAACTAGAACCAAC ATTTCTTATAATTTAACCCτCTATGGGGC GTGTGTGCTGTGCTGTGTTGTGCCTAAC AACCTATTGTGCTAATTTGTGCCACATTG CACGGAGCTTTGGGAAAACATGGCCGAT TGTGGTGCCTCCCCCCATGAAGACATTA CAAACAAGGTTTTGAGTGGATGGGACAC GAACCTTGGTGTGGTGTTGAAATTCTGC TTGGGAAAACATGGCCAACTAAACAAGG ATGCTTCTGTTTTCAAATTTGTGGAAAAG CTTTGAGTGGATGAGGAGCCTTGGAAAA AGGAAACTTATAGGACACTTACCTCATAA GCATGGCCGATCAACAAGGCTTTGGGTG GGTCATTGTGAAAATAGAAGATGAGATTC GATGGAAAGTCTTGGGAAAACATAGCTG TTAGAACAAATCCTGTCCAATCACAAGTA ATCAAACAAGGCTTTGGGTGGATGGGAG CTCAGTATATGTTGGTTATTTTCATATTTA CCTTGGGAAAACATGGTTAATCAAACAAG TTGCTGTCATTTCTCCAGTACTTTGAAGA GCTTTGAGAGGATGAAAAGCCTTGGGAA GCAATGGTTTCCAAAGTGCGTTCAAGTTA MCATGGCCAATCAAACAAAGCTTTGAGT AGCATCACAA GGATTAGGAGCCTTGGAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1622778 X 3217618 GTAGAGATGATTCTTTTGCAGAATGTTAT A/G TTCTTGACTCCGTAAAAATGTTATCTCAG SEQ_0848

CCAACCAATTACAATATCCTACCACGTTC TCATCAAAATGTAGCTCTTTCTTAATGGG AACCCCAAATGAAACACATTTTAGACTCT ACTACAATCCCACCTGG I I I I I IAATCCT AGTCCAAATATGTCTATTA I I I I IAAAAAA CTAGAATCTGAATGCCCTCTGAACCACTT TTATTAC I I I I I AATGTTCAGAAACAGGG TTAATGTTTTCAAACGCCTCTTCAGCCCA TCTCTTTATCACCCAGGCTGTAGTGCAGT TCACGTCATGTGAACGCAGAAGTTTGTG GGTGTGATCATAGCTCACAGCAGCCTCA TTGAGAGGATGTTACCA I I I I I I I CCAGG AACTCTTGGGCTCAAGTGATCCTCCTAC ^' TAAAATTGCACCAAGGTATGTCCTGCAGA CTCAGCCTCTTGAGTAGCTGTGACTATG AACATTATCTACACCTAGGAGAATTTACC GGCCTGCACCACTATTACGTTTTATCTAT TCCCCAGATCTCAGTTTCCACATCATGCG CACTAGATCCAAGGTCTCCTTGCTTGAG CTGAAGCAGGCTGTCCAAATGAACGTGT GCTCAAACTTTCTTCATGATG I I I I I GCC TTCTAAAACCCTTTGCTGCATGTATTTAT GCCGGGAGAACACGTCCTCCCATTTGTC CTAGCACGGTGTTTTCCAACCAGGGACG CATATCATTCTGCCCAGCCATTCTTCT GTACAGCCTCATGGGGAGAATGTGGC rs 12848814 3223395 GTGATTGACTGCAAATAAGAACTCCCTGT A/T GAATCTGGGTCAACCTTATAAAGATGTTA SEQ_0849 TGAATCTGATGTTAGGCTGGCCTGACCA AATTCTTCCTGGAGAAAATGCTTTAGACA TGGGTTCAAGGACATGAAATGTAGTCAA CGGTTTCTACTCTTGGCAATTTC I I I I I I I

Ul AGACGTCAATCCCATTCCTGCAAGTGTG AAAGCTGTTGTATCCCAGTTTTGGGCAA K*

00 TGTGGATCAAGTATTTGCATGGTGGTCAT GAGTCAGAAAAGCAACTCTAATAAGGTC TACAGAGGTCATTGTAACAACAAAATCAG ATGTAATTATGGTTATGCCCAGAGTTTCA ATAAAATGCTACAGTCATGGAGATGGTG AGGTGAGTTTTAAGGCTAAAATTGGGA A rs 1635238 3225211 CCTGACCTCAAGCAATCCACCCACCTCG A/G CAGTTCTCTATGTGGCAGCACATCTGCTA SEQ_0850 GCCTCCCAAAGTGCTGGGATTACAGGTG AGCTGGAAGGCATTCCTGGGTAAATTGG TGAGCCACTGCGCCTGGCTCAATATTTG GTACATGGCTCTTCTGGATTGATTGTGCA TA I I I I I AAATAGCAGGGCAGAGCCTGCT AGCTCTTCAGGGCACCACCCAGCCATCT CTTTGACAAAATGCACATGGTTTGTTCAA AAAGTATAAAATACAGGCAGGGAAAAGG TTACACTTTACTAAGAATATAGTCAGAATT CATCTCAGCCCTTTTCCTGAATTGAAAAG TACTAAGAATGAAGTGACAGAAATAATGG AGTCCTGGGAGGCCAGACACAACTGTGC TTTATAATTTATTTAGGATTTATATGGAGA AGAAGAAAACCTTGGACGCTGATTTTGCT CATTAATGGAATGACCCAAAAATCTTACT CCTACCCTGGGGAGGGACCCACGGTAA GGAACTGCATTCTTATACTGTTATCCATT GAGGCTTTCCTGCTCGAGCTACTGAGTG CAAAATTGCCTCCACCATGCCAAATTCAA CTGAAGACAGCACAATCCAGGGGTTCTC TGGAAA CACCATTGCACTGTGAATTTAGTTGGACT CCATTTTACCTTTCCTCTACTATCTGGGT CCTCTA I I I l I I GAAACGCTTATTAAAGA GATATTAGCTC I I I I I I I GTATCTAGCTCA GGGTTTCTCAATCTTGGCACTAGGGACA TTTGGGGCTAGAAGATTCTCTGTGATGG GGCCATCCTGTGAAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1726206 X 3226473 GACATTTAAGGCTGGATGGAGGATTCTC A/C GTAGTAACATTTAAGGCAAGATGAATGCT SEQ_0851

TGTGGTGGGTCTGTCCTGTGCACTGTAG AATCTGGGGTGGGGTGTCCTGTGCACTG

GGTGTTGAGCAGCATCTCCGGGCTCCAC TAGGGTGTTGAGCAGCATCCCGGGGCT

CCACCAGATGCCAGTAACATTCATCCCAT GCAGCCACCATATACCAGAAGCACACCC

TTGTGACAACCAAAAAAATGTTGCCAGAC TCCACCCCAGAGTCATCATGACCTAAAAT

ATAGCCAAATATCTCCTTGGMTAAAATC GTCTCCATACATCACCAACTGTCCCTTGG

TCCTTGGTTGTAAACAACTGCCATAGACA GGACTAAGGAACACCTGATGCCTGGTTG

GGTAGGTAGGCAGATAGATAGATAGATA CAAACCACTGCCATAGATGATGGATGGA

GATAGATAGATAGATAGATAGATAGATAT TAGACAGAAAGACAGACAGATGATAGAT

GGGTGGATGCATGAATGAATAGATACAT AGATAGATATAGATAGATAGATGATAGAT

AAGAGATAAAGATGGATGGATAGGTTAA AGATAGATAGATAGATAGAATAGATAGAT

GTATACAGGAATGAATGAATGGATAAATA AGATAGATGATAGATAGATAGATAGATAG

GATAGGTAAATGGATAGGCAAAATCTTAC ATAGATAGAACCTTTCATGCTAAGACAGA

ATGCTAAGACAGGGTTACTTGACCTCAG GTTACCTGACCTTGGCACTATGGACATT

C GA rs1635242 X 3229085 CTGCGCGCGGAGCCTACCAGGTTGGCG C/T CTCCACGGGGGACACAGTTTGCCACACC SEQ_0852

GCCACGCACTCATAGCGCCCGCTGTCCT CTCCTGTCAGGGAAGATCCAGGAAATTT

TGGGCGCGAGGTTGCGGATGTAGAGCG GGGGGGCTGGGGTCCCTTTGGCCAGAC

TCCCGTTGGGGAAAACAAACAAGTTCCC ACTCCATTGCAATGGTGTCTCCCAGGTA Hi

GTGGAGGAACTGCGAGGGGCGGATCTG GACAGTGACGTCCTGGTAGTGGGAGGCT "°

GGTACCGTCCCCGAGCACCCAGCGCAC AGGATTTGAGGTTGCTGCACGGTGACCG

GCTGGGCAGGGGCGCAGCCTTGGCAGT AAAGCAAGACCACCATCCTGTCCAGGCC

GCAGTGAATGTGAATGCTGAGCCCCGGG GTGCAGGTTGCTGGCGGTGCACATATAC

GGCAGCGAGATGTTCTCCAGCTTCTCCT TGGCCTCGATCTTGTACTTGAACCTTCCG

GGTGGATAACGGGGGGCAGTGCCGCCA TATCACTAAGGTACCGTTCTTGAGAACCT

CGTGCAGGCGGATGGCCAGGCTGTCCG CAAACCGTTGTATCCTGGTATTCGGAGT

CCCCGGCTGCATTGCTGGCCACGCACTT CATAAGAGCTCCTGGAGAAAATTAACACA

ATAGACGCCTCTGTCTGAGAAGGACGCC GTCAGCTTTGGCATAAACTGTGCCCTTTT

TCCTTGATGGAAAGGGTCCGGTTTTCGT GATAATGCTCAAACGAGCAGTATTAGTTA

GCAGGGTGATGCGGC ATCT

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs5939490 X 3230400 CCTGCTGGAATGGTTATTATCAAAAAGAC Crr GTAAGAAAGTTGAACTCATAGAAGCTGAA SEQ_0853

CAAAAACACAGACACTGGTGAAGATGTG GCAGATAGTGGAATGGTGGTTACCAGGG GAGAAAAGGGCACCCTCGTACACTGTTG GCTGGGGATGGGAGTAAAGGGAAGATAT GTGGGAATGTAATTTGGTACAACCACTGT TAATTAAAGAGTATGAAGTTCAGTTAGGA GGAAAACAGTATGGAGATTCCTCATAAAA GGAATATGCTTAAGTGATATTATACTCAT CTAACAATAGAGCTGCCTATGGTCTAGC GGCAACTATAGTTAATAACAATTTAGCTT AATCCCACTACTGGGTATTTATCCAAAGG ATACTTGAAAATTGTTGAGAGTAGATTTT AAATGACGTCAGTATGTTGACAAGACATC GTGTTGTCATCACACACATACGAAATAAG TGCACTCCCATGTTTACCACAGTGCTATT TATGCTGTAAAAAAAGGATAGAGAAAAAG CACAATAGCCAAGATATGGAATTCAGCTA AATGTTTTGTTTCTC I I I I I CATCTTTACA AGTGTCCATCAATGAATGAATGGATAAAG CTAATCCCAGAAACAGGGCCATCTTCAG GGAATGTGGTATATATGCACAATGAAATG GCAAAGGACAGCAAATGTGGGTTTAATA CCATTCTGTCTTTTC I I I I I CTTTAAAAAA GAGAATTCTGGAAGCAGGCATGAGTCCC AAAACAAACAAAAAACGAAATTCTGTCAT AGCCACTTCCAAGGTGAGCTAAGATGCC TTGCCACAACATAAATGAACCTGGAGGA ACAAGCTCAATTACTAGAGACACAGCCT CATTAGATTAAGTGAAATAAACCAGGCAC CTCCC AGACAGACAAACACTGCATGATCTCACTT ATATGTGCAG Ul

W

O rs6642197 X 3230475 TACACTGTTGGTGGGAATGTAATTTGGTA Nl GGGAAGATATTAATTAAAGAGTATGAAGT SEQ_0854

CAACCACTGTGGAAAACAGTATGGAGAT TCAGTTAGGAGGAATATGCTTAAGTGATA TCCTCATAAAACTAACAATAGAGCTGCCT TTATACTCATGGCAACTATAGTTAATAAC ATGGTCTAGCAATCCCACTACTGGGTATT AATTTAGCTTATACTTGAAAATTGTTGAG TATCCAAAGGAAATGACGTCAGTATGTTG AGTAGATTTTGTGTTGTCATCACACACAT ACAAGACATCTGCACTCCCATGTTTACCA ACGAAATAAGTATGCTGTAAAAAAAGGAT CAGTGCTATTCACAATAGCCAAGATATGG AGAGAAAAAGAATGTTTTGTTTCTC I I I I I AATTCAGCTAAGTGTCCATCAATGAATGA CATCTTTACACTAATCCCAGAAACAGGGC ATGGATAAAGGGAATGTGGTATATATGCA CATCTTCAGGCAAAGGACAGCAAATGTG CAATGAAATGCCATTCTGTCTTTTC I I I I I GGTTTAATAGAGAATTCTGGAAGCAGGC CTTTAAAAAAAAAACAAACAAAAAACGAA ATGAGTCCCAGCCACTTCCAAGGTGAGC ATTCTGTCATTTGCCACAACATAAATGAA TAAGATGCCACAAGCTCAATTACTAGAGA CCTGGAGGACATTAGATTAAGTGAAATAA CACAGCCTCTCCC ACCAGGCACAGACAGACAAACACTGCAT GATCTCACTTATATGTGCAGCGTAAGAAA GTTGAACTCATAGAAGCTGAAGCAGATA GTGGAATGGTGGTTACCAGGGGCTGGG GATGGGAGTAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs 1635243 X 3230945 AGAGAATTCTGGAAGCAGGCATGAGTCC C/T ATAAGAAAGGTAAATTAATCCTAAAGTAA SEQ_0855

CAGCCACTTCCAAGGTGAGCTAAGATGC GACTCCAGTAACTTTCTCCTACACAAACT CACAAGCTCAATTACTAGAGACACAGCC CTGGTTGAAGTGTAGATTGGGTACATAT TCTCCCTTATTTATTTATGCTCATGCTGTT GGACATAAAGATAGGACAAATAGACACTT CTCCTGAACTCCTCGGGCTAGCTGGCTG GGGACTAGTAGAGGAGAGAGGGAGGGG CATGGGCATCCCAGGCTTGCAGTGGCCA TGGCAAGGGTTGAAAAATGTACCTATTG GCCACCCCTGCCCAGAGAGGCCCTTGA GATGCTACGCTGGCTACCTGGGTAATGG GTC GATCATTTGTGCCCCAGACCTCAGCATC ACACAATATACCCGTGTGACAAGCCTGC ACATGTTCCCCCTGTGTCTAAAATAAAAG CTGAAGTTATAAAAATAAAAATAAACACTT ATTCGAGTAAAAAATTTCCCCAAATGTGT TATAAAAATTTCTCCTAATGTGTTTATGTT GTTCACCATATACTGTTTTAATGTATTATA TTGCTAGCCAATAAAATAAAAATTGACC rs 1974522 3232094 GATCCCGTGGTCTGCGGAGTGTGCAACA A/G AGTTGTAAACTGTTTGTTCTCTGGCAAAG SEQ_0856 ACGGAGGTGCCGGAGGGCCAAAGTCCA CCCCAGAAGGATATGTAGTTATTTCCGGT

Ul GATGGAAGGTGCTATGGGAATGTATCCT TTGTTGGTCCAGTGACGAGGTGACTGGG GTTGTAGGAACCTGGAATAACTTTTCTCT MGTTACAAAGTATCTGGAAGCGCTTTGT CTCTCATTACTGGGGCAGGAGAAGTGGG GTGGACATTTCAGGCAGCCTCACTGTTG TATCTGGGGTCTCCGGGTGACTCCCAAC CTGTTGGTAGGATGGGTTTGGCAGGGAC TGTGGAAAAGAAAGAGTCTTGTTGGTAAA TCTGGTTAGTTGATGAGAAGCATGAACTC GAAAGGGAGTCTTCCATTGGAATAATGA TTCCATCCTGGCGTTGGCTATCTGGGCC GGAATTCTTGGACTGGGAGGCTTTCCAA ACGTGGTAGACTCCTACTACCAAATACTT CTGGGTTTCTTGCCTCAGGGATGTTGTTA GCTTTTCCAATTCCAGCTTTGTAGACAAG TTTCCAAACACTTTGGAGTAGCCATTGAA TTAAATGCATCCTGGTCGGAAGAGGGTG TTGGTCAGTTCTTCGGTCAGTAAACTTAC TTGATAATTCATTTGGCCCTGACATATGC TAGGAATGCTGGGTTTGGACATGTGCAA TGTGTTCCTTCATTGTTCACTGGGGTTGC TGGGAGAGGAATTGTTGTACTTGATAATC TTCTGTTTCTGGATTCCCCACATAATTC TTG

Supplementary Table 3

SNP Ghr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1635247 X 3234411 GTTCCCCTATAGTAGAATCCTCAAATAAC A/G GAAAGGTCATCAACAACTTCCTCCAGAG SEQ_0857

TGTGATGTACTGGAGTCATTAACCCAGAT GTGTGCTTGTTACTTCAGGTTCAACAAGA GGTGGGGGTTGGAGTAAGGTGTGCAAA ATAACTCCATTGTGGTTGTGTTCTAGCCC GGTGTCTTCTTTCATCTTATCCTCATCTG CATGCTGGCTGAGGAAATGGTACCCAAA GTTGTGACTTAGTCTCCAAATCTGGGTCA ACGTGCTCTTCTTCACCAAGTAGAGGTA AAGTATTGCATGGGCTCAGACTCAGCCA CATCTGCTGAGGATTCTTCAGCACTGGTT AGGAGACAGCATCCAATGGAGGCTCATA ACTGTCTGCACAGGAGATGCTGAGGGG CTCACTGGATGTGGGCTCTGGTGACGAT GGAGAAATAGCAGGAAAAGGTGGTGTGA CCAACATCTGCTGCAGACCAACCCTCTG CTTCTAGACTCAAGGATGGAGGACTTGT TTGCCGTCTCTTCATGGGTGGGCTTTTCA GGTTTTAATCAATGGGGGTACTTCTGTGC TAGACTGTGTCTAATGTGTGCAGAGTAG CCTTAGGGAGA I I I I I CCCACGGACTTTG GAGATGGTTCATAAGGCTCAGATATAAGT GCTAAAATATCAGCCCAGCGCTCCGGAT GTAGGGGCTGCTGTCCCCTTCAGGTCTC TAATCTGTTTGTTTGCCATGTTTATCCTTC CTTCAGTGGAAGTTATCTCCTCAGTCTTC GTCTAGATTCAAACACTCTGCGACCTTCT TC G rs1635249 X 3234678 CATGGGTGGGCTTTTCATAGACTGTGTC CfT GGGGGTACTTCTGTGCCCTTAGGGAGAT SEQ_0858

TAATGTGTGCAGAGTAGGAGATGGTTCA TTTTCCCACGGACTTTGGCTAAAATATCA TAAGGCTCAGATATAAGTGTAGGGGCTG GCCCAGCGCTCCGGATTAATCTGTTTGT CTGTCCCCTTCAGGTCTCCTTCAGTGGA TTGCCATGTTTATCCTTCGTCTAGATTCA

K* AGTTATCTCCTCAGTCTTCTCGGAAAGGT AACACTCTGCGACCTTCTGCAACATTGGT CATCAACAACTTCCTCCAGAGGTGTGCTT CTCTGGTTCTTTTTCCGAATGCTTCCAGA GTTACTTCAGGTTCAACAAGAATAACTCC GTTTCAGCTTTCTTCTCCCTTTCTTGGCT ATTGTGGTTGTGTTCTAGCCCCATGCTG TTCTTGTCTCCATTGATGGCATCATCCTT GCTGAGGAAATGGTACCCAAAACGTGCT TGTTTTGAGGAACACCTCTTGGTCCTTTG CTTCTTCACCAAGTAGAGGTACATCTGCT GATGCAGAAGTCTCCTTGAAGTGTTCTCT GAGGATTCTTCAGCACTGGTTACTGTCT TCATCTCCCATGCCCGAGCCCCCTTCAT GCACAGGAGATGCTGAGGGGGGAGAAA CCTCCACGATGTCTTCTCTGACTCTGGAA TAGCAGGAAAAGGTGGTGTGACTTCTAG AGAGCCTTTGCACCTGGGCGTCTGCCTC ACTCAAGGATGGAGGACTTGTGGTTTTA TTTTGGATGGCAAGCCAGACCCTTTCT ATCAA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1635250 X 3235152 TAATCTGTTTGTTTGCCATGTTTATCCTTC A/G TCACTGACTTGGACCTTTGGGATGGAAA SEQ_0859

GTCTAGATTCAAACACTCTGCGACCTTCT GAGTTCCATTTGGCAACATGTATACATGT GCAACATTGGTCTCTGGTTC I I I I I CCGA GATGTGTTAGCCAAATCATTAATTATCCT ATGCTTCCAGAGTTTCAGCTTTCTTCTCC TCTGTTTGGAAGAATCCAGCTAAGGTGG CTTTCTTGGCTTTCTTGTCTCCATTGATG GCTTCGGGTATTGCTAAAGCATTGCAAG GCATCATCCTTTGTTTTGAGGAACACCTC GCAATGTCACCGACTCCCCTGGGTTCTT TTGGTCCTTTGGATGCAGAAGTCTCCTTG GCCAATTGTCACTGTGTCTTTCTCGGCTG AAGTGTTCTCTTCATCTCCCATGCCCGAG GCTGAGTGGAGGGAGACTGCACAAGTAC CCCCCTTCATCCTCCACGATGTCTTCTCT CCTATATACCATGCGGTCCATTTCATCCC GACTCTGGAAAGAGCCTTTGCACCTGGG TCACTTGAGCAATGCACTGGTACMGCC CGTCTGCCTCTTTTGGATGGCAAGCCAG TGAGTCAGATGGCTCCATGGACTTGATC ACCCTTTCTTGGTCACTGTGATTCCCACC CTCAGCCAGCCACTGCTGAGAATGGAGA GTAAAATGGTCTGCCCCTTGCTGGTTGA ACTTGCTGTCTGGGTCATCCATGGGCGC CAGCCACACATCTGTAGTAACCACT TTTCAGGATGGAGCCATCTGGAAGCACC CAGA rs1635254 X 3238565 CTCCTGGATATGAAATCCTCTGGAATTTT A/G TGACTTGGAGAATTATAAAGCTCCTAACT SEQ_0860

CTCCGTCCTTTCTGGCCACAACTGGGTC GGCTTTGCCATCTTTCCTTTTGCCCTCCT TCAGTCACTGCTTCCTCCTCCTCCTCTGC GACCATGGTTTTCTGTGTGACTTTCAAAG

Ul CTGAATCTTTGCTGACTGGGTCCTCCTTG CAAACACCTCAACATGCGAATAGGATTGT ACTTGAGCCTAAGCCCCTTTCCTTTCTGG TTTGCACATCTCCCCCCAACACACATACA TCGGCTTCAGCGTCAATGGCCTCTCGCA CATACTCACACTCACACTCATACCCACAC TATGTGTGGTTCCAATTACCATCCACCCG ACATACATGCTGTGAGACAAGGCAGCAA CCAGTGATGACTACCATATGTGCTTCTCT GCACAAGCAGGAGCATTTCACAAAATCC AGTCCAAACACATTCCGTGAGTTCCACA CTTGGCCAGCTGAATTTCATGGCTCAGC CCCCATTGCCTCTTTGACATGTCTATTTA GAATGAGCGCAGCCTCTACATGAATGCC GATAGCAAGAAGAGTCCTCAAACTGACA CTGAAGATGATGAGCAGGATGGAGCACA TCTATGAAACAAATTTATATTCTCTCCCTG GGTCCACATGTCTCTTGCCTGAATCACT ACCTAAATGTAGAATCTCGTGCCTGTTCT GCACTTTTAGAAAAGATGAGTTCAATGCT ATCTCAGTAAGTGATGCCATACTCTCTCT CCTAGCCCCTGCCTCTTTCTACACATAAG GCCTGGGGAAACTGGAAGACTAGGAGTT ATAATGTCTGGCAGGATTAAGGACTATG TTTCATGGCAGTCCTCTGCCTACTTCTGC CCTCTGTAATCTATAACCAGATGTCCCCT CCGTTCCCATTGGGAAGAAGCCAGTCAT GGCACCCAAACTTTGATGAGAATCAGCT ACTGCTTCATCT CTAATATAACTTCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID • rs5982699 X 3260412 CCATCTCGTCAGCTAAACTAGAAACTCAA CIJ GCCACTGTTTTGACAAAGTTCTCCTCAAT SEQ_0861

GCCATCCTTGCCTTCTGCCTCTCCTTCAT CTCCATTGTATAGTATTTCCTTACCTCCA

GTCTTCCTCATAGTCMCTGGTTGCCAAG TGCCCATTGCTAAAGTGGGC I I I I I I CCT

TTTAGATCCTGATGCCTAAGAATCTCTTG GCATTGTGGACAATCACTCACCTTCTTTT

GCCCAACGTGTTCTTCTCTCCACCTCTCT TATGCCGTCATAGCTTCTTGACACCTGGA

CACTGCGGTTGCATGGATATGTCTTAGAT GTATAGCACAGAGCTTAGCATACACTAA

TTTGACAACTTCTTCCTCCACCAACTCCT GCGTTCAATTGAATGAATGAATGAATGAA

TCTCATTCATCCCTTCCAGCCCATCACTG TGTGCGCATGACTGACGTTGAATTCTATT

AGACTTAGAGGGATGCCATCATCCTCAA AAGAAATGTCTAGATTTGGCCAGGCGCA

ACCCAAGGCTGAAGTTTTCCATGGGTGG GTGGCTCACGCCTGTAATCCCAGCACTT

CCTGTGCCATGCCCTGTGCTTCCCAGCC TGGGAGGCCAAGGCGGGAGGATTGCTT

TGTCCCTGGGATCTTCCTTTTGGTGATAG GAGTCCAGGAGTTTGAGACCAGCCTAGG

ATCTGGCTTGTCAAGAACAAGTAGCACAT CAACCTGGCAAAACCCTATCTCTACAAAA

CCCTGA I I I I I GTTGTTGTTGGTTCA AAAAAAAAAAAAAATTAGCCAGGCATAGT

'Jl

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs806620 X 3273302 ATTCATGGAGCTACAAGTACACTCAGCCT A/G CTATTCACATACCATGAGATTTCATCCTA SEQ_0862

AGACCTATCTGTAATCTCTTTGTGCATAC CACCAGTCAGAATGACTACTATTAAAAAA

CAAATTTTATGGTAGATCTTAACATGTAA ACAAACAAACAGATGTTGGTGAGGATGC

GCACTTTCGTTGGTTTG I I I I I GAGACAG AGAGAAMGGGAACACTTACACACTGTT

AATCTCGCTCTGTCGCCCAGGCTGCAGT CATGGGAATGTAGATTAGTACAATTTGAT

GCGGTGGCATGATCTCGGCTCACTGCAA GAAAAAGGGTGTGGAGATTTCTCAAAGG

CCTCCGCCTCCCGGGTTCAAGTGGTTCT ACCAAAAATAGAACTATCATTCAATCCAG

TCTGCCTCAGCCTCCCAAGTACCTGGGA CAACCCACTACTGGATATCTACCCAAAG

TTACAGGCGTGCACCACCACACCTGGCT GAAAAGAAATCATTATATCAAAAAGATAC

ATGGGGTTTTGCCATGTTGACCAGGCTG TTGCACTGGCTGGGCGGGGTGGCTCAT

GTCTTGAACTCCTGACCTCAGGTGATCC GCCTGTAATCCCAGCACTTTGGGAGGCT

GCTTGCCTCAGTCTGCCAAAGTGCTGGG GAGGCAGGTGGATCACTAGAGGTCAGG

ATTACAGGTGTGAGCCACCCCGCCTGGC AGTTCGAGACCAGCCTGGCCAACATGGT

CTCATGTGAGCATTTTAATTGCCACTAAA GAAACACTGTCTCTAATAAAAATACAAAA

AGATATGATGGGCTGTGATTTTGTTTCAT ACTAGCCAGTCGTGGTGGCGCACGCCT

GGTAAAGTGAGCCACACAGCAAAGTACA GTATCCCCAGCTACTCAGGAGGCTGAGG

TTTAAACACGCTGTAGCAAGATA CAGGAGAATTGCTTGAACCTGGGAGGCA

GAGGTTGCAGTGAGCCAAGATGGCACCT

CTGCACTGCAGCCTGGAAGACAGAGCGA W

GACTCCACCTCAAAATGAAAAGAAAAGAT

ACCTGTACTGGAAGCCCTATTTACAATAG

CAAAGATATGGAATCAACCTAAGTGTCCA

TCAATGGATGATGGGATAAAGAAAATGT

GGTATATGTACATACTGGAACACTATTCA

GCCACAAAAAGGAATGCAACCATGTCTTT

TGCAGCAACATGAATGGAAGTGGTGGTC

ATTTTCTTAAGTAAAACAACTCAGAAACA

AAAAGACAAATACTACGTGTTCTCACTTA

TAAGTGGGAGCTAAATAATGTTTCCAAAT

AGGCGTAGAGTGTGGAATAATAGACATT

GCTGACCGGGAAGGGTAGGAGGGGGCT

GAGGGATAAGAAGTTACTTAATGGGCAC

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs1635197 X 3284002 ATCCAGGGAGACCAGGTTGGGATGACTG A/T TGATATAATTTGAAGATATAGGAAGCAGT SEQJD863

TTGGTGCCTACACTTCAGCTGATTGGAG CATGAGCCAAGGAATGTAGACAGCCTCT CTGAATATCACAGCACATTGTTTGATTTA AGAAGCTGGAAACAGAAAGAAATCGTTTT GACAGGTATTTGTCAGTCTTGGTTTACAT TCTCCTAAAATACTCAAAACACAGCTCTG TCAACCAGTTGTAGACATTCCTAAAAGTT CAGACATCTTTATTTTATTCTGATGTCCAA TTTCAAGCCACTCTTTCATCTCTGCTCAT AAGTGTAACAGAATAAATGGGTGTTGTTT CAGGTATGGTGTGGAGAGGTTCAGAACA TAAGCAATGACATGGGTGATAATTTGTGA CCTGCCTTATCCAGGTGGGTCTGCTATC CAGCAGCCACAGACTTGCACACTCATCG ATCACAGGGATCCTTACAAAAGGGAAGT TCCTGCTGGTCAACCTTCCCTACAAGAG GGGAGAGTCAAAGCTACAGAAAAGACAC AAATGCACCCCAGGTCCTTTGCACCTGC AGGCTGCAGGCTGCAGGTTGGC TGGCCCCTCTGCTTGGAAGCTTCTTTCTC CAAATGCTGAATGATTTATTCCAACACCA CCTCCTCCGAGTGGCTTTTCATCTGTCC CTTTCCAAAATAATCTTCTCCTTTCCTTTT GCCCTGATTCACTTTTGGAAACAGTTCCT ATGTGAGTTTAGAGTTTATTTTACTGCATT TGATTCTCTCACTAGAATGTGAGCTCAAT GGAAGCTTCAGCGTTCTCACCCATGACC Ul CTGTCTAGGGTTAGGGTTAGGGTTAGGC AATCTGGAGCCATCAAT

ΓS5984618 90079719 CTCTCTCTCTCTCTCTCTTTCCCCCTCTC C/G CTCCATGTGCTAGATACGCAGGAATGTG SEQ_0864 TCTCCCTGTCTCTCTCTCTCCACCCCCCC ATTAGCTTTTCTATCACACTCCTGTCCCA CCCCCCCACCAACCCTTAATATATATATT CTGCTTATGATTCAGATTCACACTTTTGT CTTCTTTTAGGGAGTGTGACTATAGAGTA CTACCTTCAGGCTACAGTGTAGCTGAGA TGTCGGGTAGAGCCTΠTGTCTTTGCTCC CGCATGGAAATGCCTGTACTGTAGCATT TATAGCTATTTGCACTTCTGTCAGCAGGC CTGTGGGAGTGGTTTCAGGATGGAACCT r 1 1 r I CTTGGTCTGTGCAGTTTGAccTGC CTTCACTCAGCCCAGTACAGACAGCTTTA

AGGCCAGTAGGTGATGCTTATGCTTAAG TGGCTCACCTCTTCTCCAATGTCGTAAG

AGGCAATAGAGGCAGGAGCCGCTGTGT GCTGCTGCTTTGTGCTGAGGAGGGTAGG

GTGTATTTGATTTGTGTTTAACTTGAAGT GGCTCCACCTTTTGACCCATGCACGTGG

ATTTTCTACTTTCCTTAGGTGATGCGCTG GCAGCAGTTGTGATGGTATCCGCTAGTT

CACATTGGAATGCCTAGTACCCGGAGCT GGGCTGGCCTGACCTCCTGGTGGGTAG

TCAGGTTCAGTGTGGTGGGGGGAACACA TCAGGTGCCAGGAGTGGTGGACCAGGTT

GCTGAGCAGAGCGTGACTCCCTGACTTC AGATAACTTCTTGACTTTCAGGCCCCTAA

CTCACAGTTTCCTCAGTGACAAGCACAG GTGGCCCACTGGATGGCATATATGAGTC

ATGACTGGGGTGGCTGGGGGAGCTCCT CAGAAGGGGCTAGACCAGGATTATATCA

GGTGAGATGCACTGAGGTCATTGCATGG GCCCAGAATTTAGGAGCTGCTGTGATTA

GGTGAATGGTTGTTCCA AGAGGGATGGATTGGTCTCTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs5984058 X 90093314 TGGCACAAACTTCCAGTTATAAAATAAAC C/G AGAGCCTACAGAAAGAAGCCCAGATGCA SEQ_0865

AACTTCTAAGAATCTAATGTACAGCATGG GAAAAGGGAAGCAGCAAGAGTCTAGCCG GTGGTGAAGGATATTGTAATTAATTTCAT AGATCAACCCCTGGGGAACTCAGAGCCC TATGATAATCATTATTCAATATATACATAT CATGGAAAGGTTCTGTGGGAGTGCTTCT ATCAGATTATCACACTGTACACCTTGAAT TTGCTCCCCTCACCCCTGTGACAATCTG ATATAGAATCTTCATTTGTCAATTAAATGT CTGACTGCCAAACTGTTGGGGAGCCCCT TTTTTTAAATTTAAAAACTTACAAACCCAA CTGCCTTTGTAACCTAGGGCAACGCTATT AAACACACAATGTTCTTAAAAAATATCTG GACGGTAATTTAAAAACTTCCCAGTAAAA AAGATATTTTACAAAAGTCAAATTACAAT GAGAACTGGGCAGCCAGTTCATGCAGGT GTAGTTCCAATTATG I I I I I CAAGATGGC ATTGCCTGTACTCCCCTCACACCTGCACT TAACTCGGGCCATCTAATGCCTCTTCTCC GAGATGTCAGATGCCAGACTGGTTGTGC TCAGAAAGAAAATCAAATTTACTGGTGAA ACACATGGCAAGCCACTGCCATGCCTGG TGGACAAGTTTCAAATGGAAAACTGAGA GGATTCTCTGCCCTTTAGTTGTCACAACA GAAGAGACCCAGGGCCTATTG CTAGACCTCCCACAAACATATCCCACAAC CTG rs4893257 X 90093552 AGCAGCAAGAGTCTAGCCGAGATCAACC A/G GCCAGTTCATGCAGGTATTGCCTGTACT SEQ_0866

CCTGGGGAACTCAGAGCCCCATGGAAAG CCCCTCACACCTGCACTGAGATGTCAGA GTTCTGTGGGAGTGCTTCTTTGCTCCCC TGCCAGACTGGTTGTGCACACATGGCAA Ul TCACCCCTGTGACAATCTGCTGACTGCC GCCACTGCCATGCCTGGGGATTCTCTGC AAACTGTTGGGGAGCCCCTCTGCCTTTG CCTTTAGTTGTCACAACACTAGACCTCCC TAACCTAGGGCAACGCTATTGACGGTM ACAAACATATCCCACAACCTGCTATGACA TTTAAAAACTTCCCAGTAAAAGAGAACTG CTGGCAAGTATAGGGGACTGGCAGATTC GGC CT rs4893259 X 901 12672 AATTCAAATTCACAATAAGTAAGCTTCTA C/T GATACCTTTGTATATTATGTC I I M I I I I I SEQ_0867

AATAATATTTAAGTAA I I I I I I CCACTAAA CTCTATTGGTTTTCAACCATGTGGCCTGT ATTATTTATTGCTTATATAAAGTTCAAATT ATTAGTTCATTCTCACACTCTTATAAAGAT TGGCTGAGTATCCTGTACTTTTGTGTGCT ACTACTGGAGACTGGGTAATTTATACAGA AAGCCGGGCAAACTTGCAGCTGCAAGGA AAAGAAGTTTAATTGACTTATAGCTCCAC ATCAGAAATCTCTTCATTTTCTTTCAACTG ATGTCTGCGGAGGCCTAGGAAACTTACA CACTGATAA I I I I I I I GTTATGTATATCCT ATCATGGTGGAAGGTGAAGGGAATGCAA ACTATTTGCATCTTAATATTTACTTCTTAA ACTTGGACCTTTTCACATGGCGGCAGGA TATCAATTGTTGTATGTTTAAGTTCTAGA GAGTGCCAGCAAGAGCAGGGAAAATTGC GCTTCTATTTGA M T I I I GCTATAGATTTC CTTATAAAACCATCAGATΠTGTGAGAAC ATATTTCTATTGAAATTATCTATCTTTTAAT TCACTCAATATTAGGAGAACAACATGGG CCATTTTCTTGAAAATATTAAGTGTAGCT GGAAAAATGCCCCCTTAATCCAATCACTT CTTTTAATGCCTGGCTCAGATGACCTTGA CCCTCCAGGTATCCCTGAACACCTGGGG TAACTTTGATATTCTG ATTACAATTTAAGATGAGATTTGGGTG

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence rs2404259 90135544 CATGCACTTACTATATGACTTACTGATCT AAT AAATTCAAAAACATTTTAGTGCAGAACAA SEQ_0868 CATTCCAAGGTACTTACAAAAGTAAATTG GAGTAAGGATCTTCTAGACATGGAACTG AGGAATTTTCCTCACAAAAATATCTGTAT TACAGGTTGCATAGTTGTGACATGGGCT ATAAATGCTTTGAGCAGCTCTGTTTATAA GTTGTGTGATATTCTCAAAAATAGAAAAC TTGCCAATAACTGGAAACCACCCTAATGC TAGAGTGATAGATAACAGATTATTAGTTG TCTTCAATGGATGAATGAATAAACAAACT GTAGTGGTTAAGGGTGGGAGAAGATAAC GGTATATCCACAAAATGGAATGCTCCACA TACAAAGGCACAACAGGAGGAAATTTTG GCAATTAAAAGGAATAAATTATTTATACAT GCTATGATGCAACTGTTTTGTATTCTGTC GCAAAAATTTGCATAAGTCTCCAGGGAAT TGTGGTGGTGGTTTCATAAATCCTTACAT TATGCTAAGTGAGGAAAGTTAATCACAAG GTGTTAAAATTTATGTAATGTCTACCACA TAGTTATAATCTATATGATTCTATTTATAT AAATTCCATTTTACTGTATGTTAACTTAAA GACATAAAGACTGGCTATATTCTTTATGC AATATAACTAAAAAATGAAAACTATCGAA ATTTATGTGCAACAAAAAAAATGCACACC AAATAGATCACTAACTCAAACCTAAAAAC CCTTTGTTCATAAACTATTAA TAAAGAAAACAGAAGAGAAACTTTTG

'Jl

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs7053119 X 90136228 TGGCTATATTCTTTATGCATTTATGTGCA A/G CACTGATAATCAATAAGCACATGAAAATA SEQ_0869

ACAAAAAAAATGCACACCCCTTTGTTCAT TGCTAAGTGTAGTTAGTAATGAAATGCAC

AAACTATTAAAAAATTCAAAAACATTTTAG ATTAAAATTAGCAAGACATGCCTCTTCAC

TGCAGAACAAGAGTAAGGATCTTCTAGA AGCTACTAGAATGACAAAATGTAAAAGAC

CATGGAACTGTACAGGTTGCATAGTTGT TGACAATATCAAATGTTGGGGGTAATATG

GACATGGGCTGTTGTGTGATATTCTCAAA GGCCAAAGAAACTTTCACTCACAGACAAT

AATAGAAAACTAGAGTGATAGATAACAGA TGGAAAAGTAAATGGTAGAGATGCTTTG

TTATTAGTTGGTAGTGGTTAAGGGTGGG GAAAATATTTTGGCTGCTTCTCAGAAAAA

AGAAGATAACTACAAAGGCACAACAGGA AAATCATAAACATCATAACATCATGTGAC

GGAAATTTTGGCTATGATGCAACTGTTTT CCAGCAATTCCATCTCTAGGCATTTATCA

GTATTCTGTCTGTGGTGGTGGTTTCATAA AGAGAAATGAAAGGATATATCCATATGAC

ATCCTTACATGTGTTAAAATTTATGTAATG TTGTATATAAATAATTATGGCAACTTAATT

TCTACCACAAAATTCCATTTTACTGTATGT CATAACAATCCCAAATGGGAAACAACATA

TAACTTAAAAATATAACTAAAAAATGAAAA CATGTCCATCCATAAGTGAATGGATAAAT

CTATCGAAAAATAGATCACTAACTCAAAC AAATTGTATACATCTACAAGCGAATCTCA

CTAAAAACTAAAGAAAACAGAAGAGAAAC TTCAAAATTAAAATGAACAAACATGGATA

TTTTGTAACCTTACGACAGGCAATGTTAC CATGCAGTAACTTAGATAAATCTCAAGGC

TTAAACACATACAAAAAGCACTAACTGGA ATCAGTGCTGAATGAATGAAACCAGTCTC _Ut

AAAGTAAAAATTGACAAATTGGACATCAA AATAAAAGTATGTAGGGTATGATCTCATT W

CATTAAACCTTCTCTTCAAAAGACTTCATT CAAATTATATTATATAGCTTACAAAACTAC

AAGAAAATGAAAATGTAAGCTCAACCAG CTAACAGTGATAGTAATTAATAGTGGTAG

GGGAAAAATAGTCACAAAGCATTTACATA TAATAATCTGTTTACCTGAGTAAAGGTAG

TCAAATATCTTATGCATAGAATATTCAGC GAGAGGGGATTGACTGAAAGGGAAGAG

AAACTTTTACGATGTAATAATAAAAGTAC GGGAAACCTTTCTGAAGCAATTGAAATAT

AAGCAACCCAACAAAATATAGACAAAATC TCTACATCAGTATTTGGTTGGTGGATAAG

TTGGACAAACATTTCACTAAATAAAAT CAAGTGTATATATTTGTCAAAAATTATCAT

TCTGCCTAAAATATGTGA I I I I I I I AATCA

CATGTAAGTGGTACTTCAAAAATGTCAAT

TAAAATTACAAGGTGAAATAAAGTGTTTT

CAGAAAAATATATACAAACACTAAGAGAA

ATTGTTATCTTCAGAACTGTAATACTAGA

AGATATTTTTTTCAAACAGGAGAAAACTA

Supplementary Table 3

SNP Chr Position 5' Flanking Sequence SNP Base 3' Flanking Sequence SEQ ID rs932574 X 90137677 GTTTAAAATACAGTTAAATTCTAAATACAT C/G GATACTGTTGCCGCAATTTGAGACAAGT SEQ 0870

GGCAACAATACCCAAAATGCAGAATAAG CTGTTGAGCCATCCCAGCTTCACAGCTT TAAATGATGTTAAAGTGTTTTAAAGTCCTT CTTGTGAAATTGACTGAAACC I I I I I ATC ACATTGTCTGGGAAGCAGTAAAGATACTA ACAATTCAACTTCCCTTATTGCCCTATCT TTTTAAAATAGGCATTAATAGGTCAAGGC AGCTTAATTCACATCTGCACAGTTGTGGA ATGTTTTGAATTCTAGGGTAAACACTAGA TTATGGGGGCACATCTCAATAAAATTTCT ACAGTAGGAACATGTATACTTAAAGAAGA GCATGCAMGTTCCTTTTCGAATTTCTTT GGATGCTGTGATGTGCCTCCCAGACACC TCTGGGGAACCTAACCTATGACACTTGG ATTCTTTTCAGGACTAAAACACTCATTTC TGCGAGGAGTGGCTGGAGGAAGCAGAC CACAGCTGATGGGATTCTTGATTGCTGA CATAAAATATATATTTGCAGTTGGGTCAC CAGCTTCAGGAATTGCTTTCAGTGGACA TCACTGGCCAGTAATCAATGTGAATCCCA GAAAACATCTCATTCAAGGTCATATGCAC TCACTGGTAGTGAGAGGGTATAGGCCCC TTCCTTGGGGCAACCTGCATCCAATGAC AGCATGTGGTAGTTTCATGGTGTAAGAG TGTAAAATGAAGGGATACATAGGCCA GATGCACTAGTAAATTGAGCTGTACACA GG rs932575 X 90140631 TTGTAAAAA I I I I I I ATTAAGGTCATTATT A/G CAGGTTATACCACACGTGCCACTGCTTG SEQ_0871

TTTACTATTCCAGAGGACTCTTGGGATTT CTTTACTCATGTTTAGATCTAGCCTCCTG TTCCTTTTGACCTGTTAGTAAAGGTGCCT TGGTTACGAAGTGAGTCACATGCCTTTG Ul TTGACTTGCAAACGATTCTAACAGAACTA AGGCCTTTAATTACTAGAAAAAGTGGAGC 4-

O GACATAGGGTTA I M I I I I GTCTTAGGCA AGGTTGGGAGAGAATTGGAGAATGGAGC TGCTCATTTTCTCATTCAATTGCCATTTCT AACAATTTTAGCAGCTGCTGCTTCAGCTC GCCTTGACCCCTTCCACTACTCCCTCTCA ATATCCGTAAGACCTGACAAAGTGGCAT TCAGCAC I I I I I CTCCTGCTGGAGGCTC GGAAGCAGCAAGCAATCACGTAGTTTCA CTCATTTTCTTATTTACTGAGGATGCTCTT TAGCCTTTGTCTCTTTCTCTCTCTGGGAA GTCAGGATATGGAAAAATGTGGTCTGAA CTGAGTATTGTTACCCCTTCTAGCAGCCA TATGTTTAATGGGCTTCCTTCCCTATCGA TGGGACAAGAACTATACAAAGACTTACA GACATTTAATTAATTAATTTAAAAAGAATG GCTG I I I I I I I I I I I I I I I I CCTTTGGTGC TCTAATGTTGACATTTCAGAAAATGTAAA CAAAGGCAGTGAACTGACAGAATGCTTT ATAAGGGACTCTGATACTCCC TCATTTTCTCTTGACAGCCAGCAAATGTT

Claims

CLAIMSWhat is claimed is:

1. A method for assessing or aiding in assessing whether an individual is at risk for developing Type 2 diabetes mellitus (T2DM) comprising: analyzing a sample obtained from the individual for a single nucleotide polymorphism (SNP) that is associated with T2DM, wherein if the risk allele of the SNP is present in the sample, the individual is at risk for developing T2DM.

2. The method of claim 1, wherein the SNP is associated with a gene selected from the group consisting of CAMTAl, TTCl 3, RYR2, CXCR4/DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

3. The method of claim 1 or 2, wherein the sample is analyzed for two or more SNPs and each SNP is associated with a different gene associated with T2DM.

4. The method of claim 3, wherein the sample is analyzed for at least two SNPs, wherein each SNP is associated with a different gene associated with T2DM, wherein the gene is TCF7L2, SLC30A8, HHEX or TCF2.

5. The method of any one of claim3, wherein the sample is analyzed for at least two SNPs, wherein each SNP is associated with a different gene associated with T2DM, wherein the gene is TCF7L2, SLC30A8, HHEX, TCF2 CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN or ZNF649.

6. The method of any one of claims 3-5, wherein the sample is analyzed for (a) at least one SNP that is associated with TCF7L2 and (b) at least one SNP that is as- sociated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEU- ROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

7. The method of claim 6, wherein in (b), the at least one SNP is associated with one of the following genes: SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649.

8. The method of any one of claims 3-5, wherein the sample is analyzed for (a) at least one SNP that is associated with PYY and (b) at least one SNP that is associated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

9. The method of claim 8, wherein in (b), the at least one SNP is associated with one of the following genes: TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649.

10. The method of any one of claims 3-5, wherein the sample is analyzed for (a) at least one SNP that is associated with NEUR0G3 and (b) at least one SNP that is associated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB 127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, CR592664, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

11. The method of any one of claims 1-10, wherein the sample is a blood sample.

12. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP, wherein the at least one SNP is associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS and LDLR.

13. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with SLC30A8.

14. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with FGF5.

15. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with CXCR4.

16. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with HHEX.

17. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with RYR2.

18. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with DARS.

19. The method of any one of claims 1-11, wherein the sample is analyzed for at least one SNP that is associated with LDLR.

20. The method of any one of claims 1-19, wherein the SNP is located in the gene associated with T2DM.

21. The method of any one of claims 1-19, wherein the SNP is located in the transcribed region of the gene associated with T2DM.

22. The method of any one of claims 1-19, wherein the SNP is located in the coding region of the gene associated with T2DM.

23. The method of any one of claims 1-19, wherein the SNP is located in an inter- genic region of the gene associated with T2DM.

24. The method of claim 1, wherein the SNP is selected from the group consisting of SEQ. ID No 1-871.

25. A method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising: analyzing a sample obtained from the individual for a SNP selected from the group consisting of SEQ. ID No 1-871, wherein if the risk allele of the SNP is present in the sample, the individual is at risk for developing T2DM.

26. A method for assessing or aiding in assessing whether an individual is at risk for developing Type 2 diabetes mellitus (T2DM) comprising:

(a) obtaining a sample from the individual;

(b) isolating a nucleic acid from the sample; and

(c) analyzing the nucleic acid for at least one SNP that is associated with T2DM, wherein if the risk allele of the at least one SNP is present in the sample, the individual is at risk for developing T2DM.

27. The method of claim 26, comprising sequencing the nucleic acid.

28. The method of claim 26, wherein analyzing the nucleic acid comprises a hybridization step.

29. The method of claim 28, wherein the hybridization step is carried out on a micro-array.

30. The method of claim 28, wherein the hybridization step is carried out on a bead- array.

31. The method of claim 26, comprising an amplification step.

32. The method of claim 26, wherein the amplification step comprises a PCR reaction.

33. The method of any one of the claims 26-32, wherein at least one of SNP is associated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUR0G3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

34. The method of any one of claims 26-32, wherein the sample is analyzed for two or more SNPs and each SNP is associated with a different gene associated with T2DM.

35. The method of claim 34, wherein the sample is analyzed for at least two SNPs, wherein each SNP is associated with a different gene associated with T2DM, wherein the gene is TCF7L2, SLC30A8, HHEX or TCF2.

36. The method of claim 34 or 35, wherein the sample is analyzed for at least two SNPs, wherein each SNP is associated with a different gene associated with T2DM, wherein the gene is TCF7L2, SLC30A8, HHEX, TCF2 CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN or ZNF649.

37. An isolated nucleic acid comprising at least one SNP associated with T2DM.

38. The isolated nucleic acid of claim 37, wherein the at least one SNP is associated with a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUR0G3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

39. An isolated nucleic acid that hybridizes to the nucleic acid of claim 37 or claim 38.

40. The isolated nucleic acid of claim 39, wherein the nucleic acid is an siRNA.

41. The isolated nucleic acid of any one of claims 37-40, wherein the nucleic acid is an allele-specific probe.

42. The isolated nucleic acid of any one of claims 37-40, wherein the nucleic acid is a detectably labelled probe.

43. The isolated nucleic acid of claim 42, wherein the detectably labelled probe is a radioactive probe, a chemiluminescent probe or a fluorescent probe.

44. An isolated polypeptide encoded by the nucleic acid of any one of claims 37-42.

45. A kit for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising: a nucleic acid comprising at least one SNP associated with T2DM and one or more reagents useful for analyzing samples for the alleles of one or more SNPs associated with T2DM.

46. The kit of claim 45, wherein the at least one SNP is associated with a gene selected from the group consisting of CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

47. The kit of claim 45 or claim 46, wherein the at least one SNP is TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649.

48. A method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising: analyzing a sample obtained from the individual for a polypeptide encoded by a nucleic acid comprising at least one SNP located in a coding region of a gene associated with T2DM wherein if the polypeptide is present in the sample, the individual is at risk for developing T2DM.

49. A method for assessing or aiding in assessing whether an individual is at risk for developing T2DM comprising: analyzing a sample obtained from the individual for a polypeptide encoded by a nucleic acid comprising at least one SNP located in a coding region of a gene associated with T2DM; wherein analyzing comprises comparing the polypeptide encoded by the risk allele of the T2DM- associated gene to a polypeptide encoded by the allele that does not confer risk; and wherein if the polypeptides perform differently, the individual is at risk for developing T2DM.

50. The claim of 49, wherein the assay is an enzymatic assay.

51. The claim of 50, wherein the assay is an antibody binding assay.

52. A method of screening for a therapeutic for treatment of T2DM comprising: contacting an agent with a polypeptide encoded by a nucleic acid comprising a SNP located in a coding region of a gene associated with T2DM, wherein if the agent binds to the polypeptide, the agent is a candidate therapeutic for treatment ofT2DM.

53. A method of assessing or aiding in assessing if an individual will be responsive to treatment for T2DM comprising: determining a genotype of the individual, wherein the genotype is defined by at least one SNP selected from the group consisting of: SEQ. ID No 1-871 wherein the genotype is indicative of responsiveness to treatment for T2DM.

54. The method of claim 53, wherein the at least one SNP is associated with a gene selected from the group consisting of CAMTAl, TTC13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSPAN5, DB 127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

55. The method of claim 53, wherein the SNP is associated with a gene and the gene is TCF7L2, SLC30A8, HHEX, TCF2, CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN and ZNF649.

56. The method of claim 53, wherein the at least one SNP is associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS and LDLR.

57. A microarray comprising at least one SNP selected from the group consisting of SEQ ID NO 1-871.

58. The microarray of claim 57, wherein the at least one SNP is associated with a gene selected from the group consisting of: CAMTAl, TTC 13, RYR2, CXCR4, DARS, SLC6A20, VPS 13 A, FAM69B, HHEX, TCF7L2, MMP26, EXT2, NLGN2, LDLR, ZNF649, ZNF613, ZNF350, ZNF615, FLJ90680, FLJ27365, MXRA5, SLC44A3, LOC642123, RAFTLIN, TSP AN5, DB127798, SLC30A8, LOC387761, ALX4, KIRREL3, BTGl, PYY, CR592664, NEUROG3, RYR2, FGF5, TCF2, WNT8B, LRRC59, NR5A2, ICAl and PEX26.

59. The microarray of claim 57, wherein the at least one SNP is associated with a gene selected from the group consisting of SLC30A8, FGF5, CXCR4, HHEX, RYR2, DARS and LDLR.

60. The microarray of claim 57, wherein the at least one SNP is associated with a gene and the gene is the sample is analyzed for at least two SNPs, wherein each SNP is associated with a different gene associated with T2DM, and the gene is TCF7L2, SLC30A8, HHEX, TCF2 CXCR4/DARS, ALX4, CAMTAl, EXT2, FGF5, KIRREL3, LDLR, LOC387761, LRRC59, MMP26, NLGN2, NR5A2, PEX26, RAFTLIN or ZNF649.

61. The method of any one of claims 1-32, 48-50 and 53-56, further comprising performing a fasting plasma glucose test on the individual.

62. The method of any one of claims 1-32, 48-50 and 53-56, further comprising performing an oral glucose tolerance test on the individual.

63. The method of any one of claims 1-32, 48-50 and 53-56, further comprising determining the fasting serum insulin level of the individual.

64. The method of any one of claims 1-32, 48-50 and 53-56, further comprising determining serum C-peptide levels of the individual.