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WO2008059367A8 - Penem prodrugs - Google Patents

Penem prodrugs

Info

Publication number
WO2008059367A8
WO2008059367A8 PCT/IB2007/003531 IB2007003531W WO2008059367A8 WO 2008059367 A8 WO2008059367 A8 WO 2008059367A8 IB 2007003531 W IB2007003531 W IB 2007003531W WO 2008059367 A8 WO2008059367 A8 WO 2008059367A8
Authority
WO
WIPO (PCT)
Prior art keywords
prodrugs
penem
sulopenem
relates
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/003531
Other languages
French (fr)
Other versions
WO2008059367A1 (en
Inventor
Katherine Elizabeth Brighty
Anthony Marfat
Dale Gordon Mcleod
John Paul O'donnell
Stephen Richard Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39190251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008059367(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of WO2008059367A1 publication Critical patent/WO2008059367A1/en
Publication of WO2008059367A8 publication Critical patent/WO2008059367A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to prodrugs of sulopenem of formula (I): wherein R1 is -(C2-C8)alkyl, or a solvate or hydrate thereof. The invention also relates to the preparation, formulation, and use of the prodrugs of sulopenem to treat a disorder such as an infection in a patient in need thereof.
PCT/IB2007/003531 2006-11-14 2007-11-09 Penem prodrugs Ceased WO2008059367A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86566906P 2006-11-14 2006-11-14
US60/865,669 2006-11-14
US97881607P 2007-10-10 2007-10-10
US60/978,816 2007-10-10

Publications (2)

Publication Number Publication Date
WO2008059367A1 WO2008059367A1 (en) 2008-05-22
WO2008059367A8 true WO2008059367A8 (en) 2008-10-09

Family

ID=39190251

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003531 Ceased WO2008059367A1 (en) 2006-11-14 2007-11-09 Penem prodrugs

Country Status (5)

Country Link
AR (1) AR063799A1 (en)
CL (1) CL2007003277A1 (en)
PE (1) PE20081163A1 (en)
TW (1) TW200829242A (en)
WO (1) WO2008059367A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101868452B (en) 2007-10-10 2014-08-06 诺华股份有限公司 Spirocyclic pyrrolidines and their application against HCV and HIV infection
CN119039295B (en) * 2024-08-16 2025-11-04 浙江大学 A prodrug for anti-infection and its application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (en) * 1980-04-30 1985-05-18 カネボウ株式会社 1,3-dioxolen-2-one derivative
US4619924A (en) * 1984-05-18 1986-10-28 Pfizer Inc. 2-alkylthiopenem derivatives
US5013729A (en) * 1987-05-11 1991-05-07 Pfizer Inc. Diastereomeric 5R,6S-6-(1R-hydroxyethyl)-2-(cis-1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids

Also Published As

Publication number Publication date
TW200829242A (en) 2008-07-16
AR063799A1 (en) 2009-02-18
PE20081163A1 (en) 2008-08-15
CL2007003277A1 (en) 2008-05-23
WO2008059367A1 (en) 2008-05-22

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