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WO2007135091A3 - Module de lecture d'une biopuce - Google Patents

Module de lecture d'une biopuce Download PDF

Info

Publication number
WO2007135091A3
WO2007135091A3 PCT/EP2007/054823 EP2007054823W WO2007135091A3 WO 2007135091 A3 WO2007135091 A3 WO 2007135091A3 EP 2007054823 W EP2007054823 W EP 2007054823W WO 2007135091 A3 WO2007135091 A3 WO 2007135091A3
Authority
WO
WIPO (PCT)
Prior art keywords
light
read
channel
biochip
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/054823
Other languages
German (de)
English (en)
Other versions
WO2007135091A2 (fr
Inventor
Reiner Spolaczyk
Juergen Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenteris GmbH
Original Assignee
Zenteris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenteris GmbH filed Critical Zenteris GmbH
Publication of WO2007135091A2 publication Critical patent/WO2007135091A2/fr
Publication of WO2007135091A3 publication Critical patent/WO2007135091A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne un module de lecture d'une biopuce, sur laquelle se trouvent des points fluorescents avec des informations biologiques. Le module selon l'invention comporte une seule diode électroluminescente émettrice sensiblement ponctuelle servant de source de lumière. Un canal d'éclairage servant à éclairer la biopuce et un canal de lecture servant à représenter les différents points fluorescents sur une caméra sont séparés l'un de l'autre au moyen d'un miroir dichroïque au moins dans une zone. Les ouvertures numériques du canal d'éclairage et du canal de lecture sont réalisées différemment au moyen d'une tôle insérée dans le canal de lecture dans la zone située entre le miroir dichroïque et la caméra, l'ouverture numérique de canal de lecture étant plus petite que celle du canal d'éclairage. Un filtre permettant de sélectionner spectralement la lumière de la diode électroluminescente est en outre inséré dans le canal d'éclairage pour que les points fluorescents ne soit excités que par la lumière de longueur d'onde différente de la lumière fluorescente et pouvant être filtrée facilement dans le canal de lecture. Le module selon l'invention de lecture d'une biopuce est très facilement réalisé et permet cependant une détection très efficace des points fluorescents.
PCT/EP2007/054823 2006-05-18 2007-05-18 Module de lecture d'une biopuce Ceased WO2007135091A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006023945A DE102006023945A1 (de) 2006-05-18 2006-05-18 Verfahren und optisches Modul zum Auslesen von Biochips
DE102006023945.8 2006-05-18

Publications (2)

Publication Number Publication Date
WO2007135091A2 WO2007135091A2 (fr) 2007-11-29
WO2007135091A3 true WO2007135091A3 (fr) 2008-04-17

Family

ID=38608111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/054823 Ceased WO2007135091A2 (fr) 2006-05-18 2007-05-18 Module de lecture d'une biopuce

Country Status (2)

Country Link
DE (1) DE102006023945A1 (fr)
WO (1) WO2007135091A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007052281A1 (de) 2007-11-02 2009-05-07 Zenteris Gmbh Einschritt-Multiplex-Immuntest
KR101022769B1 (ko) 2008-10-20 2011-03-17 삼성전자주식회사 바이오칩용 광검출 장치
DE102008054313B4 (de) 2008-11-03 2012-12-13 Zenteris Gmbh Kartusche und Vorrichtung zur Untersuchung biologischer Proben mit temperaturgesteuerten biologischen Reaktionen
DE102017124786B4 (de) * 2017-10-24 2021-08-12 Asphericon Gmbh Beleuchtungsvorrichtung mit Strahlformer für die transkutane Fluorometrie
DE102019107146B4 (de) * 2019-01-30 2021-02-25 Jenoptik Optical Systems Gmbh Athermale Laseroptik aus Kunststoff
CN111487233A (zh) * 2020-05-27 2020-08-04 安徽皖仪科技股份有限公司 一种基于复眼透镜的pcr光路系统
CN115753698A (zh) * 2021-09-02 2023-03-07 安徽皖仪科技股份有限公司 一种用于pcr荧光检测扫描头的光学系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003038413A1 (fr) * 2001-11-01 2003-05-08 Diachip Co., Ltd. Appareil permettant d'analyser l'image fluorescente d'une biopuce
US20040066511A1 (en) * 2001-05-10 2004-04-08 Yokogawa Electric Corporation Biochip reader
GB2395267A (en) * 1999-06-26 2004-05-19 Packard Instrument Co Inc Assay analysis
US20050140980A1 (en) * 2003-12-25 2005-06-30 Hei-Tong Ching Optical measurement apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2395267A (en) * 1999-06-26 2004-05-19 Packard Instrument Co Inc Assay analysis
US20040066511A1 (en) * 2001-05-10 2004-04-08 Yokogawa Electric Corporation Biochip reader
EP1650551A2 (fr) * 2001-05-10 2006-04-26 Yokogawa Electric Corporation Lecteur de biopuce
WO2003038413A1 (fr) * 2001-11-01 2003-05-08 Diachip Co., Ltd. Appareil permettant d'analyser l'image fluorescente d'une biopuce
US20050140980A1 (en) * 2003-12-25 2005-06-30 Hei-Tong Ching Optical measurement apparatus

Also Published As

Publication number Publication date
DE102006023945A1 (de) 2007-11-22
WO2007135091A2 (fr) 2007-11-29

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