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WO2007135091A3 - Module for reading from a biochip - Google Patents

Module for reading from a biochip Download PDF

Info

Publication number
WO2007135091A3
WO2007135091A3 PCT/EP2007/054823 EP2007054823W WO2007135091A3 WO 2007135091 A3 WO2007135091 A3 WO 2007135091A3 EP 2007054823 W EP2007054823 W EP 2007054823W WO 2007135091 A3 WO2007135091 A3 WO 2007135091A3
Authority
WO
WIPO (PCT)
Prior art keywords
light
read
channel
biochip
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/054823
Other languages
German (de)
French (fr)
Other versions
WO2007135091A2 (en
Inventor
Reiner Spolaczyk
Juergen Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenteris GmbH
Original Assignee
Zenteris GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenteris GmbH filed Critical Zenteris GmbH
Publication of WO2007135091A2 publication Critical patent/WO2007135091A2/en
Publication of WO2007135091A3 publication Critical patent/WO2007135091A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

The invention relates to a module for reading from a biochip on which fluorescent spots with biological information are situated. The module has a single for instance point-type radiating light-emitting diode as light source. An illumination channel for illuminating the biochip and a read-out channel for imaging the fluorescent spots onto a camera are separated from one another at least in regions by means of a dichroic mirror. The numerical apertures of the illumination channel and of the read-out channel are formed differently by the provision of a diaphragm in the read-out channel in the region between the dichroic mirror and the camera, wherein the numerical aperture in the read-out channel is smaller than that in the illumination channel. Furthermore, a filter for spectrally selecting the light of the light-emitting diode is arranged in the illumination channel, such that the fluorescent spots are only excited with light that differs from the fluorescent light in terms of the wavelength and can be filtered out simply in the read-out channel.
PCT/EP2007/054823 2006-05-18 2007-05-18 Module for reading from a biochip Ceased WO2007135091A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006023945A DE102006023945A1 (en) 2006-05-18 2006-05-18 Method and optical module for reading biochips
DE102006023945.8 2006-05-18

Publications (2)

Publication Number Publication Date
WO2007135091A2 WO2007135091A2 (en) 2007-11-29
WO2007135091A3 true WO2007135091A3 (en) 2008-04-17

Family

ID=38608111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/054823 Ceased WO2007135091A2 (en) 2006-05-18 2007-05-18 Module for reading from a biochip

Country Status (2)

Country Link
DE (1) DE102006023945A1 (en)
WO (1) WO2007135091A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007052281A1 (en) 2007-11-02 2009-05-07 Zenteris Gmbh Single-step multiplex immunoassay
KR101022769B1 (en) 2008-10-20 2011-03-17 삼성전자주식회사 Photodetector for Biochip
DE102008054313B4 (en) 2008-11-03 2012-12-13 Zenteris Gmbh Cartridge and apparatus for assaying biological samples with temperature-controlled biological responses
DE102017124786B4 (en) * 2017-10-24 2021-08-12 Asphericon Gmbh Illumination device with beam shaper for transcutaneous fluorometry
DE102019107146B4 (en) * 2019-01-30 2021-02-25 Jenoptik Optical Systems Gmbh Athermal laser optics made of plastic
CN111487233A (en) * 2020-05-27 2020-08-04 安徽皖仪科技股份有限公司 PCR light path system based on fly-eye lens
CN115753698A (en) * 2021-09-02 2023-03-07 安徽皖仪科技股份有限公司 An optical system for PCR fluorescence detection scanning head

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003038413A1 (en) * 2001-11-01 2003-05-08 Diachip Co., Ltd. Apparatus for analyzing florescent image of biochip
US20040066511A1 (en) * 2001-05-10 2004-04-08 Yokogawa Electric Corporation Biochip reader
GB2395267A (en) * 1999-06-26 2004-05-19 Packard Instrument Co Inc Assay analysis
US20050140980A1 (en) * 2003-12-25 2005-06-30 Hei-Tong Ching Optical measurement apparatus

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2395267A (en) * 1999-06-26 2004-05-19 Packard Instrument Co Inc Assay analysis
US20040066511A1 (en) * 2001-05-10 2004-04-08 Yokogawa Electric Corporation Biochip reader
EP1650551A2 (en) * 2001-05-10 2006-04-26 Yokogawa Electric Corporation Biochip Reader
WO2003038413A1 (en) * 2001-11-01 2003-05-08 Diachip Co., Ltd. Apparatus for analyzing florescent image of biochip
US20050140980A1 (en) * 2003-12-25 2005-06-30 Hei-Tong Ching Optical measurement apparatus

Also Published As

Publication number Publication date
DE102006023945A1 (en) 2007-11-22
WO2007135091A2 (en) 2007-11-29

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