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WO2007128581A2 - Dispositif ophtalmologique - Google Patents

Dispositif ophtalmologique Download PDF

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Publication number
WO2007128581A2
WO2007128581A2 PCT/EP2007/004115 EP2007004115W WO2007128581A2 WO 2007128581 A2 WO2007128581 A2 WO 2007128581A2 EP 2007004115 W EP2007004115 W EP 2007004115W WO 2007128581 A2 WO2007128581 A2 WO 2007128581A2
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
dermis
eye
myopia
sclera
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2007/004115
Other languages
German (de)
English (en)
Other versions
WO2007128581A3 (fr
Inventor
Tobias Koller
Theo Seiler
Stefan Seiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IROC AG
Original Assignee
IROC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IROC AG filed Critical IROC AG
Priority to EP07725037.1A priority Critical patent/EP2015720B1/fr
Publication of WO2007128581A2 publication Critical patent/WO2007128581A2/fr
Publication of WO2007128581A3 publication Critical patent/WO2007128581A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A61F2009/00846—Eyetracking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00853—Laser thermal keratoplasty or radial keratotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00865—Sclera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/009—Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Definitions

  • the invention relates to a device for the prevention of defective vision or dermal disease of an eye.
  • Myopia refers to a form of ametropia in which the focus lies in front of the retina.
  • myopia There are two principal forms of myopia: the "refractive myopia” lo at normal eye axis length, but too strong refractive power, and the so-called “axis myopia” with normal refractive power but too long eye axis.
  • the prior art knows various ophthalmic devices which serve to correct this vision defect.
  • the second form - the "axis myopia" - describes a common eye disease in which the eye grows longer due to (passive) sclera growth, especially in the first three decades of life, with a gradual and excessive lengthening The reasons for this have not yet been found, and it is believed that genetic predisposition plays an important role.
  • myopia axis three forms of "myopia axis" are known: school myopia, benign progressive myopia, and malignant progressive myopia.
  • the eyeball begins to stretch just before puberty (between the ages of 10 and 12 years) and steadily increases myopia until it is about 20-25 years old.
  • the eyes may e.g. reach a refractive power of about minus 6 diopters.
  • the present invention is intended to provide a device and a method with which the defective vision described above can be treated as a result of a dermis or dermis change of an eye.
  • the device is characterized by a device for solidifying the dermis located in the posterior segment of the eye.
  • the solidification of the dermis takes place with a device according to the invention with at least one radiation source for irradiating the dermis, wherein the dermis to be solidified is preferably irradiated homogeneously.
  • Homogeneous irradiation with electromagnetic radiation is present when the same amount of radiation hits the dermis per unit area.
  • Such a homogeneous irradiation can be achieved with a point-shaped radiation source, the bundled radiation of which is guided over the spherically curved dermis.
  • a homogeneous irradiation of the dermis can also be achieved with a device which distributes the radiation homogeneously.
  • the invention preferably provides special measures for homogenizing the radiation distribution.
  • control devices for the radiation distribution over the dermis such that the radiation impinging on the dermis per unit area depending on the location on the dermis is selectively adjustable.
  • a special embodiment of the invention provides that a device is provided for determining properties of the dermis and / or other components of the eye.
  • these measurements at different locations of the dermis may lead to different results, which in turn may be important for the above-mentioned control of the intensity distribution of the electromagnetic radiation as a function of the location of the eye in particular embodiments of the invention.
  • the device according to the invention for solidifying the dermis by means of electromagnetic radiation may be designed so that it has a selected distance from the dermis or rests on this, i. E.
  • the device may have a predetermined distance from the cornea when used as intended or be brought into contact with the cornea.
  • the invention also teaches different radiation sources for the electromagnetic radiation and different techniques to guide this radiation to the place of use. Details of this can be found in the dependent claims and in the following description of exemplary embodiments.
  • the invention is provided towards the inlet at which the electromagnetic radiation is irradiated on the sclera, equipped with an endoscope that is coupled to a surgical microscope namely conferencezügFderart that the surgeon during the ⁇ applying the ELERT ⁇ romag netic radiation can observe the eye and especially the dermis or parts thereof.
  • the invention also teaches a method for preventing a refractive error of an eye due to a dermis disease in which solidification of the dermis is performed with electromagnetic radiation.
  • a photoinitiator is preferably used, which causes a so-called "cross-linking" in the skin.
  • the method preferably applies the radiation homogeneously to the sclera or, according to a special control program, unevenly if certain areas of the sclera are to be irradiated differently as other areas of the same, for example because of different sclera strengths or because of different targeting (cross-linking) depending on the location of the sclera.
  • FIG. 1 shows a device for the prevention of defective vision of an eye
  • Figure 2 shows a modified embodiment of a device for the prevention of ametropia of the eye
  • FIG. 3 shows a further embodiment of a device for the prevention of ametropia of the eye
  • FIG. 1 schematically shows an eye with a cornea 10, a lens 12, a vitreous body 14, a retina 16 and a dermis (sclera) 18.
  • a band 20 and a cushion 22 lie directly on the outside of the dermis (sclera) 18.
  • the band 20 and the pad 22 are shaped such that electromagnetic radiation can be irradiated in the direction of the dermis 18.
  • the band 20 and the pad 22 may be mirrored on the side facing away from the sclera side.
  • Fiber light guides 24 are connected to the belt 20 and the pad 22. It is also possible that in each case a plurality of optical fibers are connected to the band 20 and the pad 22.
  • the optical fibers 24 are fed from a radiation source 26, for example a laser or LEDs, operated in either cw-mode or pulsed.
  • a power supply 28 the radiation source 26 is driven, that is, the amount of radiation emitted via the optical fibers 24 can be selectively adjusted as needed.
  • a control and regulation unit 30 is provided, which can be computer-controlled, for example.
  • a so-called "diffuser" (not shown) is located in the beam path of the radiation emitted by the optical fibers 24.
  • the function of the diffuser is to radiate the radiation emitted by the optical fibers 24 as uniformly as possible over the sclera
  • the diffuser may be formed as a frosted glassy material
  • Another embodiment of the design of the band 20 and the pad 22 provides that the light is coupled in at a front end of the band or pad and this then on its path parallel to the sclera by staggered reflection surfaces successively emerges from the tape or cushion to one side to irradiate the sclera with homogeneous fluence (energy per unit area).
  • the embodiment of Figure 1 may also be equipped with an endoscope (not shown) coupled to a surgical microscope (not shown). This may be provided with a filter which allows the surgeon to be operated without interference from the radiation source 26 and the conductor fibers. 24 guided electromagnetic radiation, on the one hand observe the eye parts of interest and on the other hand, the diffusers can be properly positioned under view.
  • FIG. 2 shows a modification of the treatment of the dermis 18 with electromagnetic radiation.
  • electromagnetic radiation is applied to the dermis 18 via the interior of the eye through the cornea 10, the lens 12, the vitreous body 14 and the retina 16.
  • Bundled radiation 34 emerges from a radiation focusing device 32, which is connected to a radiation source 26.
  • the focused radiation 34 impinges on the dermis 18 at a point 38, taking into account effects that may occur within the eye and may cause a change in the direction of radiation.
  • the focused radiation 34 is guided over the dermis 18 in such a way that substantially the same or a desired, locally varying amount of radiation strikes the dermis per unit area.
  • This "scanning" of the dermis 18 with radiation 34 requires movement of the radiation relative to the dermis, this can be done, for example, with a mirror (not shown) in a manner known per se.This movement of the radiation is indicated by arrows in FIG.
  • the radiation source 26, which feeds the radiation-focusing device 32, is driven by means of a power supply 28.
  • the amount of radiation emitted by the radiation source 26 can be selectively adjusted as needed.
  • a control and regulation unit 30 is provided, which can be computer-controlled, for example.
  • a plurality of radiation sources 26 and / or radiation focusing devices 32 can be used to effect irradiation of the dermis 18 at several locations simultaneously. This would have for example the advantage that a treatment shortened or that the irradiation of the dermis could be carried out symmetrically.
  • a radiation sensor (not shown) may be provided which detects part of the radiation directed towards the dermis.
  • the measuring signal of the sensor is transmitted via a line in the control and regulation unit for processing, so that the control unit can drive according to the power supply unit for the radiation source or the radiation sources. It is preferably provided that each individual radiation source is selectively controllable, so that different radiation intensities can be provided for the individual radiation sources.
  • a so-called adjustment beam known as such may be used for the positioning of the eye, and such a beam is sometimes referred to in the literature as a "fixation light beam".
  • a so-called adjustment beam known as such may be used for the positioning of the eye, and such a beam is sometimes referred to in the literature as a "fixation light beam".
  • the positioning of the eye with respect to the described devices and the laser beam 34 can be improved.
  • eye-tracker are eye tracking systems that optically track possible movements of the eye and instruments used for surgery, such as laser beams, according to eye movement tracking the.
  • FIG. 3 shows a further device for irradiation of the dermis 18.
  • a device 36 which serves to bring about a targeted change in the radiation direction of the radiation 34.
  • the device 36 which can be positioned directly on or near the cornea, it is possible to adjust the angle of incidence of the radiation directed onto the sclera so that radiation can be brought up to very close to the limbus. It is, according to another variant of the invention also possible to promote the positioning of the described devices and devices on the eye, with a spectacle frame.
  • a photomediator can be applied and applied to the dermis 18 in a homogeneous or targeted manner before the treatment.
  • the irradiation is carried out with infrared wavelengths or wavelengths in the visible optical range.
  • rose bengal or other substances that absorb in the optical wavelength range or in the near infrared serve as the photoinitiator.
  • the photomediator releases radicals, which in turn generate new molecular bonds and thus strengthen the tissue ("crosslinking", "x-linking").
  • the radiation source 26 is designed accordingly. It is also possible to perform a solidification of the dermis without photosensitizer only by the radiation itself. However, care must be taken here that the retina 16 is not damaged by short-wave radiation.
  • the solidification of the dermis with devices according to FIGS. 1, 2 and 3 can be improved by the use of special measurements on the eye.
  • the process parameters (amount of radiation, photoinitiator) with regard to the solidification of the dermis 18 can then be set as described above.
  • microscopy for the evaluation of tissue effects which may occur, in order to avoid unwanted disturbances. It can also be provided during use of the device to determine the intraocular pressure, in order to derive therefrom optionally control variables for the hardening of the dermis 18. decision The same applies to the use of known methods for optical spectroscopy for tissue characterization or else methods which enable tissue characterization by means of opto-optic spectroscopy.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Laser Surgery Devices (AREA)
  • Radiation-Therapy Devices (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

L'invention concerne un dispositif pour prévenir un défaut visuel affectant un oeil au moyen d'un système (20, 22; 32) destiné à renforcer la sclérotique (18).
PCT/EP2007/004115 2006-05-09 2007-05-09 Dispositif ophtalmologique Ceased WO2007128581A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07725037.1A EP2015720B1 (fr) 2006-05-09 2007-05-09 Dispositif ophthalmologique pour prévenir de la myopie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06009539.5A EP1854438B1 (fr) 2006-05-09 2006-05-09 Dispositif ophthalmologique pour prévenir de la myopie
EP06009539.5 2006-05-09

Publications (2)

Publication Number Publication Date
WO2007128581A2 true WO2007128581A2 (fr) 2007-11-15
WO2007128581A3 WO2007128581A3 (fr) 2008-01-03

Family

ID=37110205

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/004115 Ceased WO2007128581A2 (fr) 2006-05-09 2007-05-09 Dispositif ophtalmologique

Country Status (2)

Country Link
EP (2) EP1854438B1 (fr)
WO (1) WO2007128581A2 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008046834A1 (de) 2008-09-11 2010-03-18 Iroc Ag Steuerprogramm zum Steuern elektromagnetischer Strahlung für eine Quervernetzung von Augengewebe
EP2380535A1 (fr) 2010-04-21 2011-10-26 Iroc AG Dispositif de réticulation d'un tissu oculaire à l'aide d'un rayonnement électromagnétique
EP2407132A1 (fr) 2010-06-24 2012-01-18 IROC Services AG Dispositif de préparation d'un ýil pour l'introduction d'un photo-stabilisateur
EP3053553A1 (fr) 2015-02-09 2016-08-10 IROC Services AG Dispositif de prévention de la myopie axiale
US10028657B2 (en) 2015-05-22 2018-07-24 Avedro, Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
US10137239B2 (en) 2011-06-02 2018-11-27 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
US10258809B2 (en) 2015-04-24 2019-04-16 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
US10350111B2 (en) 2014-10-27 2019-07-16 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
US11179576B2 (en) 2010-03-19 2021-11-23 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
US11207410B2 (en) 2015-07-21 2021-12-28 Avedro, Inc. Systems and methods for treatments of an eye with a photosensitizer

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024044806A1 (fr) * 2022-09-02 2024-03-07 The University Of Newcastle Traitement de la myopie

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EP0464138A1 (fr) * 1989-03-17 1992-01-08 Candela Laser Corporation Procede et appareil a laser de sclerostomie non invasive
US5445608A (en) * 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
AU9294298A (en) * 1997-08-25 1999-03-16 Advanced Photodynamic Technologies, Inc. Treatment device for topical photodynamic therapy and method of making same
US5997141A (en) * 1998-03-06 1999-12-07 Odyssey Optical Systems, Llc System for treating the fundus of an eye
US6443976B1 (en) * 1999-11-30 2002-09-03 Akorn, Inc. Methods for treating conditions and illnesses associated with abnormal vasculature
US6494878B1 (en) * 2000-05-12 2002-12-17 Ceramoptec Industries, Inc. System and method for accurate optical treatment of an eye's fundus
KR20070011557A (ko) * 2004-05-07 2007-01-24 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 근시 치료
US20070123844A1 (en) * 2005-10-19 2007-05-31 Shelly Henry Method for treating ocular disorders

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008046834A1 (de) 2008-09-11 2010-03-18 Iroc Ag Steuerprogramm zum Steuern elektromagnetischer Strahlung für eine Quervernetzung von Augengewebe
WO2010028830A1 (fr) 2008-09-11 2010-03-18 Iroc Ag Programme de commande destiné à commander un rayonnement électromagnétique lors de la réticulation transversale de tissu oculaire
US8887734B2 (en) 2008-09-11 2014-11-18 Iroc Innocross Ag Control program for controlling electromagnetic radiation for cross-linking eye tissue
US11179576B2 (en) 2010-03-19 2021-11-23 Avedro, Inc. Systems and methods for applying and monitoring eye therapy
EP2380535A1 (fr) 2010-04-21 2011-10-26 Iroc AG Dispositif de réticulation d'un tissu oculaire à l'aide d'un rayonnement électromagnétique
EP2907489A1 (fr) 2010-04-21 2015-08-19 IROC Innocross AG Dispositif de réticulation d'un tissu oculaire à l'aide d'un rayonnement électromagnétique
EP2907490A1 (fr) 2010-04-21 2015-08-19 IROC Innocross AG Dispositif de réticulation d'un tissu oculaire à l'aide d'un rayonnement électromagnétique
EP2407132A1 (fr) 2010-06-24 2012-01-18 IROC Services AG Dispositif de préparation d'un ýil pour l'introduction d'un photo-stabilisateur
US10137239B2 (en) 2011-06-02 2018-11-27 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
US10350111B2 (en) 2014-10-27 2019-07-16 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
US11219553B2 (en) 2014-10-27 2022-01-11 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
US12427062B2 (en) 2014-10-27 2025-09-30 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3053553A1 (fr) 2015-02-09 2016-08-10 IROC Services AG Dispositif de prévention de la myopie axiale
US10258809B2 (en) 2015-04-24 2019-04-16 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
US11167149B2 (en) 2015-04-24 2021-11-09 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
US12070618B2 (en) 2015-04-24 2024-08-27 Avedro, Inc. Systems and methods for photoactivating a photosensitizer applied to an eye
US10028657B2 (en) 2015-05-22 2018-07-24 Avedro, Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
US11207410B2 (en) 2015-07-21 2021-12-28 Avedro, Inc. Systems and methods for treatments of an eye with a photosensitizer
US12214039B2 (en) 2015-07-21 2025-02-04 Advero, Inc. Systems and methods for treatments of an eye with a photosensitizer

Also Published As

Publication number Publication date
WO2007128581A3 (fr) 2008-01-03
EP2015720A2 (fr) 2009-01-21
EP1854438A1 (fr) 2007-11-14
EP1854438B1 (fr) 2018-07-04
EP2015720B1 (fr) 2018-07-11

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