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WO2007117264A3 - Compositions et procedes de production d'immunoglobulines - Google Patents

Compositions et procedes de production d'immunoglobulines Download PDF

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Publication number
WO2007117264A3
WO2007117264A3 PCT/US2006/030545 US2006030545W WO2007117264A3 WO 2007117264 A3 WO2007117264 A3 WO 2007117264A3 US 2006030545 W US2006030545 W US 2006030545W WO 2007117264 A3 WO2007117264 A3 WO 2007117264A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdnas
methods
compositions
expression system
antibody
Prior art date
Application number
PCT/US2006/030545
Other languages
English (en)
Other versions
WO2007117264A2 (fr
Inventor
Vidadi Yusibov
Anna Hull
Vadim Mett
Original Assignee
Fraunhofer Usa Inc
Vidadi Yusibov
Anna Hull
Vadim Mett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Usa Inc, Vidadi Yusibov, Anna Hull, Vadim Mett filed Critical Fraunhofer Usa Inc
Priority to EP06850507.2A priority Critical patent/EP1919504B1/fr
Priority to BRPI0614475A priority patent/BRPI0614475B8/pt
Priority to JP2008525248A priority patent/JP2009502207A/ja
Priority to KR1020087002842A priority patent/KR101446025B1/ko
Priority to CN2006800361361A priority patent/CN101378781B/zh
Priority to CA2616859A priority patent/CA2616859C/fr
Priority to AU2006341615A priority patent/AU2006341615A1/en
Publication of WO2007117264A2 publication Critical patent/WO2007117264A2/fr
Priority to IL189067A priority patent/IL189067A0/en
Publication of WO2007117264A3 publication Critical patent/WO2007117264A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des oligonucléotides permettant d'isoler des ADNc d'anticorps humains à partir de cellules ou de lignées cellulaires, telles les hybridomes. L'invention porte aussi sur des ADNc qui codent au moins un CDR de chaîne lourde ou légère d'un anticorps monoclonal humain qui se lie à l'antigène protégeant contre le Bacillus anthracis ; et des ADNc qui codent au moins un CDR d'une chaîne lourde ou légère d'un anticorps monoclonal humain qui se lie au facteur létal du B. anthracis. L'invention a également trait à des vecteurs d'expression qui renferment un ou plusieurs ADNc isolés selon les procédés de l'invention, à des cellules hôtes exprimant un ou plusieurs ADNc de l'invention, ainsi que des plantes et des animaux transgéniques qui expriment un ou plusieurs ADNc de l'invention. Dans certains modes de réalisation de l'invention, le système d'expression correspond à un système d'expression reposant sur les plantes. En outre, l'invention se rapporte à des compositions d'anticorps comprenant un ou plusieurs anticorps produits en exprimant un ADNc isolé selon les procédés de l'invention dans un système d'expression approprié. De plus, l'invention porte sur des kits contenant une ou plusieurs compositions, ainsi que des procédés de production et l'utilisation desdites compositions.
PCT/US2006/030545 2005-08-03 2006-08-03 Compositions et procedes de production d'immunoglobulines WO2007117264A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP06850507.2A EP1919504B1 (fr) 2005-08-03 2006-08-03 Anticorps diriges contre l'antigene protecteur de bacillus anthracis
BRPI0614475A BRPI0614475B8 (pt) 2005-08-03 2006-08-03 polipeptídeo, anticorpo, ácido nucleico, vetores, célula hospedeira, composição e processos de produção de anticorpo
JP2008525248A JP2009502207A (ja) 2005-08-03 2006-08-03 イムノグロブリンの産生のための組成物および方法
KR1020087002842A KR101446025B1 (ko) 2005-08-03 2006-08-03 면역글로불린의 생산을 위한 조성물 및 방법
CN2006800361361A CN101378781B (zh) 2005-08-03 2006-08-03 制造免疫球蛋白的组合物和方法
CA2616859A CA2616859C (fr) 2005-08-03 2006-08-03 Compositions et procedes de production d'immunoglobulines
AU2006341615A AU2006341615A1 (en) 2005-08-03 2006-08-03 Compositions and methods for production of immunoglobulins
IL189067A IL189067A0 (en) 2005-08-03 2008-01-28 Compositions and methods for production of immunoglobulins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70565305P 2005-08-03 2005-08-03
US60/705,653 2005-08-03

Publications (2)

Publication Number Publication Date
WO2007117264A2 WO2007117264A2 (fr) 2007-10-18
WO2007117264A3 true WO2007117264A3 (fr) 2008-05-22

Family

ID=38581506

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/030545 WO2007117264A2 (fr) 2005-08-03 2006-08-03 Compositions et procedes de production d'immunoglobulines

Country Status (10)

Country Link
US (1) US8962278B2 (fr)
EP (1) EP1919504B1 (fr)
JP (1) JP2009502207A (fr)
KR (1) KR101446025B1 (fr)
CN (1) CN101378781B (fr)
AU (1) AU2006341615A1 (fr)
BR (1) BRPI0614475B8 (fr)
CA (1) CA2616859C (fr)
IL (1) IL189067A0 (fr)
WO (1) WO2007117264A2 (fr)

Cited By (1)

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US8951791B2 (en) 2003-02-03 2015-02-10 Ibio, Inc. System for expression of genes in plants

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US7692063B2 (en) * 2002-11-12 2010-04-06 Ibio, Inc. Production of foreign nucleic acids and polypeptides in sprout systems
EP1919504B1 (fr) 2005-08-03 2013-10-16 iBio, Inc. Anticorps diriges contre l'antigene protecteur de bacillus anthracis
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
WO2010082134A1 (fr) * 2009-01-14 2010-07-22 Iq Therapeutics Bv Anticorps combinés destinés au traitement et à la prévention d'une maladie provoquée par bacillus anthracis, ainsi que par les bactéries connexes et par leurs toxines
US9244061B2 (en) * 2009-06-12 2016-01-26 Vaccine Technologies, Incorporated Methods and compositions for diagnostic assays for measuring cell mediated immune response
CA2776144C (fr) 2009-09-29 2020-10-27 Fraunhofer Usa, Inc. Anticorps diriges contre l'hemagglutinine du virus de la grippe, compositions, et procedes associes
GB2480298A (en) * 2010-05-13 2011-11-16 Secr Defence Antibodies against Bacillus anthracis
RU2470307C1 (ru) * 2011-11-09 2012-12-20 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Способ определения наличия протективного антигена сибирской язвы на основе иммунодетекции, сопряженной с полимеразной цепной реакцией
WO2017122017A1 (fr) * 2016-01-12 2017-07-20 Crescendo Biologics Limited Molécules thérapeutiques
GB201607968D0 (en) 2016-05-06 2016-06-22 Crescendo Biolog Ltd Chimeric antigen receptor
EP3565842A1 (fr) 2017-01-06 2019-11-13 Crescendo Biologics Limited Anticorps à domaine unique dirigés contre la mort cellulaire programmée (pd-1)
GB201711068D0 (en) 2017-07-10 2017-08-23 Crescendo Biologics Ltd Therapeutic molecules binding PSMA
US20200362051A1 (en) 2017-11-13 2020-11-19 Crescendo Biologics Limited Molecules that bind to cd137 and psma
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
CA3228786A1 (fr) * 2021-08-25 2023-03-02 Ibio, Inc. Anticorps anti-cd25

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US8962278B2 (en) 2015-02-24
KR20080045677A (ko) 2008-05-23
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IL189067A0 (en) 2008-06-05
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BRPI0614475A2 (pt) 2011-03-29
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