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WO2007116731A1 - Composition contenant de la coenzyme a réduite - Google Patents

Composition contenant de la coenzyme a réduite Download PDF

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Publication number
WO2007116731A1
WO2007116731A1 PCT/JP2007/056362 JP2007056362W WO2007116731A1 WO 2007116731 A1 WO2007116731 A1 WO 2007116731A1 JP 2007056362 W JP2007056362 W JP 2007056362W WO 2007116731 A1 WO2007116731 A1 WO 2007116731A1
Authority
WO
WIPO (PCT)
Prior art keywords
coa
composition
cells
reduced
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/056362
Other languages
English (en)
Japanese (ja)
Inventor
Hirokazu Sakamoto
Toshihide Fujii
Hiroshi Kubo
Hideyuki Kishida
Kazunori Hosoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of WO2007116731A1 publication Critical patent/WO2007116731A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • composition comprising reduced coenzyme A
  • Patent Document 1 bovine placenta extract
  • Patent Document 2 whey extract
  • herbal extracts such as hormones, vitamins, and saponins
  • botanical extract Patent Document 2
  • sesame Extracts such as peonies and chili peppers
  • Coenzyme A is an active substance present in large quantities in the living body, and consists of pantothenic acid, adenine, ribose, cysteamine and phosphoric acid. It is a coenzyme for acetylation in vivo and has an extremely important role in the metabolism of carbohydrates, lipids and proteins. For example, the process of the tricarboxylic acid cycle, hepatic glycogen storage, acetyl Essential for choline synthesis, regulation of cholesterol levels, regulation of plasma lipid levels and steroid synthesis. Most of CoA existing in the living body is reduced CoA (CAS No. 85-61-0) similar to the present invention.
  • Patent Document 2 JP-A-7-138179
  • Patent Document 6 Japanese Patent Laid-Open No. 08-245352
  • composition according to claim 1 The composition according to claim 1, which is used for pet food, feed or feed.
  • the composition containing reduced CoA of the present invention can activate various cells by increasing the amount of intracellular ATP, and further enhance various functions of the cells.
  • cosmetics, oral preparations, scalp and hair preparations, foods, pharmaceutical products, quasi-drugs, nutritional supplements, veterinary drugs, pet foods, feeds and feeds, etc. containing reduced CoA, which has a cell activation effect, as active ingredients It can be applied to the prevention and treatment of various diseases, cosmetics, prevention and treatment of various symptoms due to aging, daily health maintenance or health promotion, and the like.
  • FIG. 9 A) Change in intracellular ATP level when acid-type CoA is added to GI-1
  • Preservatives include benzoic acid, sodium benzoate, ethanol, sodium edetate, dry sodium sulfite, citrate, glycerin, salicylic acid, sodium salicylate, dibutylhydroxytoluene, D-sorbitol, sorbic acid, sorbic acid
  • examples include potassium, sodium dehydroacetate, isoptyl parabenzoate, isopropyl paraoxybenzoate, ethyl oxyraxybenzoate, butyl paraoxybenzoate, propyl oxybenzoate, methyl noroxybenzoate, propylene glycol, and phosphoric acid.
  • Antioxidants include citrate, citrate derivatives, vitamin C and its derivatives, lycobenes, vitamin A, carotenoids, vitamin B and its derivatives, flavonoids, polyphenols, selenium, thiosulfate Sodium, vitamin E and its derivatives, alpha lipoic acid and its derivatives, pycnogenol, flavangenol, superoxide dismutase (SOD), glutathione peroxidase, glutathione-S-transferase, glutathione reductase, catalase, ascorbic acid Examples include peroxidase, reduced coenzyme Q, dartathione, and mixtures thereof.
  • composition containing the reduced CoA of the present invention As edible foods, it is conceivable to eat the composition containing the reduced CoA of the present invention as it is, to eat foods and beverages containing these.
  • the quasi-drug composition in the present invention refers to a quasi-drug specified in the Pharmaceutical Affairs Law, and in particular, nutritional tonic, physical fatigue, decreased physical fitness after illness, loss of appetite, malnutrition, fever Oral preparations that are described or described as nutritional supplements such as sexual illness and prenatal birth Liquids and capsules such as extracts, elixirs, syrups, tinctures, and limonades
  • Example 1 an example of the effect of the reduced CoA of the present invention on cells was shown.
  • Examples 2 and 3 are comparative examples of the effects of the reduced CoA of the present invention and the CoA precursor and the acid-containing CoA that are already used in commercially available products. This result shows the superiority of oA over CoA precursor and oxidized CoA in terms of the effect of increasing intracellular ATP, that is, the effect of activating cells.
  • the reduced CoA used in Examples 1 to 3 was confirmed to have a purity of 93% by liquid chromatography (Example 4).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Insects & Arthropods (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne une composition qui contient une coenzyme A réduite représentée par la formule générale ci-dessous, qui présente une sécurité excellente, qui possède un excellent effet d'activation cellulaire et qui est efficace pour soigner diverses pathologies ou anomalies de diverses fonctions cellulaires, parmi lesquelles le vieillissement ou le maintien ou le renforcement de la santé au quotidien; une composition destinée à l'administration par voie orale; une composition cosmétique; une composition destinée à la sphère orale; une composition destinée au cuir chevelu ou au cheveux; une composition comestible; une composition pharmaceutique; une composition quasi-médicamenteuse; un complément nutritionnel; une composition pharmaceutiques vétérinaire; un aliment pour animaux de compagnie; un aliment pour bétail; et un aliment pour poissons.
PCT/JP2007/056362 2006-03-29 2007-03-27 Composition contenant de la coenzyme a réduite Ceased WO2007116731A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006091487 2006-03-29
JP2006-091487 2006-03-29

Publications (1)

Publication Number Publication Date
WO2007116731A1 true WO2007116731A1 (fr) 2007-10-18

Family

ID=38581029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/056362 Ceased WO2007116731A1 (fr) 2006-03-29 2007-03-27 Composition contenant de la coenzyme a réduite

Country Status (1)

Country Link
WO (1) WO2007116731A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110463846A (zh) * 2019-07-30 2019-11-19 河南科技学院 留兰香提取物在制备抗宠物衰老药物或宠物食品中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4913994B1 (fr) * 1970-09-09 1974-04-04
JPS5031051A (fr) * 1973-07-26 1975-03-27
JPS59212431A (ja) * 1983-05-19 1984-12-01 Suntory Ltd 抗変異原性剤
JPS63152309A (ja) * 1986-08-11 1988-06-24 Lion Corp 皮膚外用剤
JPH0249729A (ja) * 1988-05-31 1990-02-20 Lion Corp 皮膚外用剤
JPH04108721A (ja) * 1990-08-28 1992-04-09 Lion Corp 細胞賦活剤組成物
JPH08245352A (ja) * 1995-03-03 1996-09-24 Lion Corp 口腔用組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4913994B1 (fr) * 1970-09-09 1974-04-04
JPS5031051A (fr) * 1973-07-26 1975-03-27
JPS59212431A (ja) * 1983-05-19 1984-12-01 Suntory Ltd 抗変異原性剤
JPS63152309A (ja) * 1986-08-11 1988-06-24 Lion Corp 皮膚外用剤
JPH0249729A (ja) * 1988-05-31 1990-02-20 Lion Corp 皮膚外用剤
JPH04108721A (ja) * 1990-08-28 1992-04-09 Lion Corp 細胞賦活剤組成物
JPH08245352A (ja) * 1995-03-03 1996-09-24 Lion Corp 口腔用組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110463846A (zh) * 2019-07-30 2019-11-19 河南科技学院 留兰香提取物在制备抗宠物衰老药物或宠物食品中的应用

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