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WO2007149005A1 - Injection cannula - Google Patents

Injection cannula Download PDF

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Publication number
WO2007149005A1
WO2007149005A1 PCT/RU2006/000325 RU2006000325W WO2007149005A1 WO 2007149005 A1 WO2007149005 A1 WO 2007149005A1 RU 2006000325 W RU2006000325 W RU 2006000325W WO 2007149005 A1 WO2007149005 A1 WO 2007149005A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
central channel
injection
partition
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2006/000325
Other languages
French (fr)
Russian (ru)
Inventor
Jury Anatoleivich Sukhonos
Aleksandr Mikhailovich Belov
Sergei Sergeevich Batskov
Sergei Viktorovich Chepur
Vera Ivanovna Belova
Anatoly Evgenievich Sosyukin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/RU2006/000325 priority Critical patent/WO2007149005A1/en
Publication of WO2007149005A1 publication Critical patent/WO2007149005A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/283—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291—Shafts with additional lateral openings

Definitions

  • the invention relates to medicine, namely to needles used in devices for injection of drugs, mixed immediately before their use.
  • the urgent task is to quickly and safely mix separately stored components of the drug immediately before the injection.
  • a number of devices such as syringes are known [see, for example, FR 2604363,
  • the components of the drug are in volumes isolated from each other until the formation of their mixture, which is initiated by violating the integrity of the elements separating these volumes. Moreover, previously isolated volumes are communicated with each other, and a mixture of components is introduced to the patient using the usual type of injection needles that are part of the devices under consideration.
  • the above devices include a housing, inside of which are located an injection needle, as well as two closed containers, containing components of the injected drug that are not physically connected to each other.
  • the devices contain a hollow transfer element of the type of double-edged needle, providing opening of the tanks and communication tanks with each other when exposed to external pressure.
  • injection needles are known that differ in design from needles of a conventional type. Design features of these needles contribute to the improvement of injection conditions [see, for example, RU 2008026, RU2061505, RU2243000].
  • the closest in design to the claimed injection needle is the injection needle JRU2243000], which is selected by the authors as the closest 5 analogs.
  • This needle has a through central channel connected to its open input and output ends, as well as openings communicating with the central channel, made on the side surface of the needle and located near its output end. Due to the selected location and cross-sectional area ⁇ ′′ of the holes on the lateral surface and the shape of the needle tip, the risk of thrombosis of the injection channel is reduced and a uniform dosage distribution of the administered drug into the drug depot is achieved.
  • this needle can only perform the function of injecting a drug, and cannot perform any additional
  • the present invention is based on the task of expanding the functionality of an injection needle, which makes it possible to simplify the design of devices in the case of using the specified needle in injection devices intended for introducing components of a drug mixed up immediately before injection.
  • At least one partition is formed in the central through channel of the needle, completely overlapping the central channel, at least one opening is located on the side surface of the needle body on different sides of the needle, and the drug component is introduced under the influence of external pressure into the needle inlet the drug does not pass directly to its outlet through the central channel, but is squeezed into the volume surrounding the needle through the hole located on one side of the septum (holes ), Blended with a screen located in said other component, and then the mixture of components fed back through a central channel situated on the other side of the partition opening (s), after which the mixture components are transported through the central through-channel to the outlet needle.
  • the inventive needle determines the expansion of its functionality when using the inventive needle in injection devices intended for the introduction of components of the drug that are mixed immediately before injection.
  • the inventive needle in addition to its main function of injecting a drug, also performs the function of a transfer element of a component contained in one isolated volume to another isolated volume containing another component.
  • the needle can also perform the function of a means by which the integrity of the elements isolating the volumes from each other is violated.
  • the number of partitions formed in the central channel of the needle should be one less than the number of components placed each in its own isolated volume.
  • the partitions and holes on the side surface of the needle body should be located along the length of the needle so that in the working position of the needle within the boundaries of each of the isolated volumes was one of the partitions with openings located on opposite sides of it.
  • FIG.l presents a General view of the inventive needle
  • figure 2 presents 5 General view of the syringe tube, which uses the inventive needle
  • Fig. 3 shows a general view of a syringe with a piston in which the inventive needle is used.
  • the needle (Fig. 1) contains a housing I 5 inside of which, along its longitudinal axis ⁇ , a central channel 2 is made, connected to the inlet and outlet openings 3 and 4 of the needle located at opposite ends of the needle. In the central channel 2, completely overlapping partitions are formed
  • FIG. 2 shows a syringe tube containing a deformable body, in the upper part of which is installed the inventive needle 8.
  • the body is formed by two isolated from each other tanks 9 and 10, separated by membranes 11 and 20 12.
  • the tanks 9 and 10 are connected to each other, for example, using a threaded connection,
  • In the upper reservoir 9 there is a powdered component of the drug
  • in the lower reservoir 10 is the liquid component of the drug.
  • the tank 9 has a neck 13 connected by a threaded connection to the nozzle 14, in which the needle is fixed 8.
  • the needle 8 near the inlet 3 in the central channel 2 contains a partition 5, on one side of which on the side surface of the body 1 of the needle 8 there are opposite other holes 6, and on the other side - holes 7.
  • Fig. 3 shows a syringe with a piston containing a rigid body 15, in the upper part of which the inventive needle 8 is installed.
  • capsule 16 with the first powder component of the drug, isolated from each other, capsule 17 with the second powdered preparation and capsule 18 with liquid component.
  • the case 15 of the syringe has a neck 13, on which, with the help of the nozzle 14, a needle 8 is fixed, containing two partitions 5 in the central channel
  • the inventive needle 8 in the initial position is set so that its lower part with a partition 5 and holes 6 and 7 is located within the boundaries of the upper tank 9, and its inlet end, on which the inlet 3 is located, is placed above the membrane 11.
  • the nozzle 14 is moved down the neck 13 until the needle 8 occupies a position where its inlet end with hole 3 pierces the membrane 11 and 12, will be in the upper part of the reservoir 10, and the holes 6 will still be located within the upper reservoir 9. Press on the deformable body of the syringe tube, while the liquid component from the lower reservoir 10 enters the central channel 2 of the needle 8 through its inlet hole
  • the inventive needle 8 is in the initial position so that its lower part passes through the capsules 16 and 17, while the inlet end wglt 8, on which the inlet 3 is located, is located above the bottom of the capsule 17 closest to the inlet end of the needle 8 with the hole 3 of the needle 8 is the first partition 5 and located along different sides of the hole b and 7 are within the boundaries of the volume of the capsule 17, and the next second partition 5 and the holes 6 and 7 located on different sides of it are located within the boundaries of the capsule 16.
  • external pressure is applied to the piston 19, it begins to move to the upper part case 15, while the input end with the hole 3 of the needle 8 pierces the upper part of the capsule shell 18 and the lower part of the capsule shell 17.
  • the liquid component from the capsule 18 enters the central channel 2 of the needle 8 through its inlet 3, ytesnyaetsya through openings b located below the first partition wall 5, into the capsule 17, where it is mixing with the capsule located in said first pulverulent component.
  • the resulting mixture of components from the volume of the capsule 17 enters through the openings 7 located above the first septum 5 into the central channel 2 of the needle 8 and is displaced through the openings 6 located below the second septum 5 into the volume of the capsule 16.
  • a second powder component is mixed into the mixture of the first two components, and the resulting three-component mixture through the holes 7 located above the second partition 5, enters the central channel 2 of the needle 8 and then transport I thereon to the output end of the needle 8 which is arranged an outlet opening 4.
  • the piston 19 in the housing 15 and discharge reservoirs 18, 17, 16 the lower portion of the needle 8 is included in the stem 20 and the channel 21 is moved therein.
  • the inventive needle can be widely used in various types of injection devices such as syringes for injection of a mixture in the form of a solution or suspension of two or more components of a drug.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The inventive injection cannula comprises a body (1) provided with a central channel, (2) which is embodied therein and is connected to input and output orifices (3, 4) arranged on the opposite cannula sides, and with orifices (6, 7), which are embodied on the side surface of the body and communicate with the central channel (2). Said invention is characterised in that at least one baffle (5) is formed in the central channel (2) for completely closing said channel and at least one orifice is placed on opposite sides of said baffle (5) on the side surface of the body (1).

Description

ИГЛА ДЛЯ ИНЪЕКЦИЙ INJECTION NEEDLE

Область техникиTechnical field

Изобретение относится к области медицины, а именно к иглам, используемым в устройствах для инъекций лекарственных препаратов, смешиваемых непосредственно перед их применением.The invention relates to medicine, namely to needles used in devices for injection of drugs, mixed immediately before their use.

Предшествующий уровень техникиState of the art

В терапевтической практике актуальной является задача быстрого и безопасного смешивания раздельно хранящихся компонентов лекарственного препарата непосредственно перед проведением инъекции.In therapeutic practice, the urgent task is to quickly and safely mix separately stored components of the drug immediately before the injection.

Известен ряд устройств типа шприцов [см., например, FR 2604363,A number of devices such as syringes are known [see, for example, FR 2604363,

RU2258537], обеспечивающих возможность отдельного размещения внутри шприца несовместимых друг с другом или нестабильных после смешивания компонентов, и приготовления в этих же шприцах смесей указанных компонентов в пригодной для инъекций форме.RU2258537], providing the possibility of separate placement inside the syringe of incompatible with each other or unstable after mixing the components, and preparation in the same syringes of mixtures of these components in a form suitable for injection.

В данных устройствах компоненты лекарственного препарата находятся в изолированных друг от друга объемах до момента образования их смеси, которое инициируется путем нарушении целостности элементов, разделяющих указанные объемы. При этом ранее изолированные объемы сообщаются друг с другом, а смесь компонентов вводится пациенту с помощью входящих в состав рассматриваемых устройств инъекционных игл обычного типа.In these devices, the components of the drug are in volumes isolated from each other until the formation of their mixture, which is initiated by violating the integrity of the elements separating these volumes. Moreover, previously isolated volumes are communicated with each other, and a mixture of components is introduced to the patient using the usual type of injection needles that are part of the devices under consideration.

Так, вышеописанные устройства включают корпус, внутри которого расположены- инъекционная- игла-, а также два- закрытых- резервуара-, содержащие компоненты вводимого препарата, физически не связанные друг с другом. Кроме того, устройства содержат полый элемент переноса типа обоюдоострой иглы, обеспечивающий вскрытие резервуаров и сообщение резервуаров друг с другом при воздействии внешнего давления.So, the above devices include a housing, inside of which are located an injection needle, as well as two closed containers, containing components of the injected drug that are not physically connected to each other. In addition, the devices contain a hollow transfer element of the type of double-edged needle, providing opening of the tanks and communication tanks with each other when exposed to external pressure.

Наличие в рассматриваемых инъекционных устройствах специальных приспособлений для вскрытия резервуаров и переноса компонентов усложняют конструкцию устройств.The presence of special devices for opening reservoirs and component transfer in the injection devices under consideration complicates the design of the devices.

В настоящее время известны инъекционные иглы, отличающиеся по конструкция от игл обычного типа. Конструктивные особенности указанных игл способствуют улучшению условий инъектирования [см., например, RU 2008026, RU2061505, RU2243000].Currently, injection needles are known that differ in design from needles of a conventional type. Design features of these needles contribute to the improvement of injection conditions [see, for example, RU 2008026, RU2061505, RU2243000].

Наиболее близкой по конструкции к заявляемой инъекционной игле является инъеiαщонная игла JRU2243000], которая выбрана авторами в качестве ближайшего 5 аналога.The closest in design to the claimed injection needle is the injection needle JRU2243000], which is selected by the authors as the closest 5 analogs.

Данная игла имеет сквозной центральный канал, соединенный с ее открытыми входным и выходным концами, а также сообщающиеся с центральным каналом отверстия, выполненные на боковой поверхности иглы и расположенные вблизи ее выходного конца. Благодаря выбранным месту расположения и площади ιо сечения отверстий на боковой поверхности и форме острия иглы снижается риск тромбирования инъекционного канала и достигается равномерное дозированное распределение вводимого препарата в лекарственное депо.This needle has a through central channel connected to its open input and output ends, as well as openings communicating with the central channel, made on the side surface of the needle and located near its output end. Due to the selected location and cross-sectional area ιо of the holes on the lateral surface and the shape of the needle tip, the risk of thrombosis of the injection channel is reduced and a uniform dosage distribution of the administered drug into the drug depot is achieved.

Однако данная игла может выполнять только функцию инъектирования лекарственного препарата, и не может выполнять какие-либо дополнительныеHowever, this needle can only perform the function of injecting a drug, and cannot perform any additional

15 функции, которые позволили бы в случае применения указанной иглы в инъекционных устройствах, предназначенных для введения смешиваемых непосредственно перед инъекцией компонентов лекарственного препарата, упростить конструкцию устройств.15 functions that would allow in the case of the use of the specified needle in injection devices intended for the introduction of components of the drug mixed up immediately before injection to simplify the design of the devices.

Раскрытие изобретенияDisclosure of invention

20 В основу настоящего изобретения положена задача расширения функциональных возможностей инъекционной иглы, что позволяет в случае применения указанной иглы в инъекционных устройствах, предназначенных для введения смешиваемых непосредственно перед инъекцией компонентов лекарственного препарата, упростить конструкцию устройств.20 The present invention is based on the task of expanding the functionality of an injection needle, which makes it possible to simplify the design of devices in the case of using the specified needle in injection devices intended for introducing components of a drug mixed up immediately before injection.

25 Поставленная задача решается тем, что в игле для инъекций, содержащей корпус, в котором выполнен центральный канал, соединенный с расположенными на противоположных концах иглы входным и выходным отверстиями, а также отверстия на боковой поверхности корпуса, сообщающиеся с центральным каналом, согласно изобретению в центральном канале сформирована по меньшей мере одна зо полностью перекрывающая указанный канал перегородка, при этом по разные стороны от перегородки на боковой поверхности корпуса расположено по меньшей мере по одному отверстию. Новым по сравнению с блюкайiшш аналогом в заявляемом изобретении является то, что в центральном канале сформирована по меньшей мере одна полностью перекрывающая указанный канал перегородка, при этом по разные стороны от перегородки на боковой поверхности корпуса расположено по меньшей мере по одному отверстию.25 The problem is solved in that in an injection needle containing a housing in which a central channel is made, connected to inlet and outlet openings located at opposite ends of the needle, and also openings on the side surface of the housing communicating with the central channel, according to the invention, in the central the channel is formed at least one zo completely blocking the specified channel, the partition, while on different sides of the partition on the side surface of the housing is located at least one about tverstvo. A new compared to the bluish analogue in the claimed invention is that at least one partition is completely formed in the central channel, and at least one opening is located on different sides of the partition on the side surface of the housing.

Благодаря тому, что в центральном сквозном канале иглы сформирована по меньшей мере одна перегородка, полностью перекрывающая центральный канал, по разные стороны от которой на боковой поверхности корпуса иглы расположено по меньшей мере по одному отверстию, вводимый под действием внешнего давления во входное отверстие иглы компонент лекарственного препарата не проходит сразу к ее выходному отверстию по центральному каналу, а выдавливается в окружающий иглу объем через расположенное по одну сторону от перегородки отверстие (отверстия), смешивается с находящимся в указанном объеме другим компонентом, а затем смесь компонентов вновь поступает в центральный канал через расположенное по другую сторону от перегородки отверстие (отверстия), после чего смесь компонентов транспортируется по центральному сквозному каналу к выходному отверстию иглы.Due to the fact that at least one partition is formed in the central through channel of the needle, completely overlapping the central channel, at least one opening is located on the side surface of the needle body on different sides of the needle, and the drug component is introduced under the influence of external pressure into the needle inlet the drug does not pass directly to its outlet through the central channel, but is squeezed into the volume surrounding the needle through the hole located on one side of the septum (holes ), Blended with a screen located in said other component, and then the mixture of components fed back through a central channel situated on the other side of the partition opening (s), after which the mixture components are transported through the central through-channel to the outlet needle.

Указанные конструктивные особенности иглы обуславливают расширение ее функциональных возможностей при использовании заявляемой иглы в инъекционных устройствах, предназначенных для введения смешиваемых непосредственно перед инъекцией компонентов лекарственного препарата. В данных устройствах заявляемая игла помимо своей основной функции инъектирования лекарственного препарата выполняет также функцию элемента переноса компонента, содержащегося в одном изолированном объеме, в другой изолированный объем, содержащий иной компонент. При этом игла может также выполнять функцию средства, с помощью которого нарушается целостность элементов, изолирующих объемы друг от друга.These design features of the needle determine the expansion of its functionality when using the inventive needle in injection devices intended for the introduction of components of the drug that are mixed immediately before injection. In these devices, the inventive needle, in addition to its main function of injecting a drug, also performs the function of a transfer element of a component contained in one isolated volume to another isolated volume containing another component. In this case, the needle can also perform the function of a means by which the integrity of the elements isolating the volumes from each other is violated.

Количество перегородок, сформированных в центральном канале иглы, должно быть на одну меньше, чем количество компонентов, помещенных каждый в свой изолированный объем. При этом перегородки и отверстия на боковой поверхности корпуса иглы должны быть расположены по длине иглы таким образом, чтобы в рабочем положении иглы в границах каждого из изолированных объемов находилась одна из перегородок с расположенными по разные стороны от нее отверстиями.The number of partitions formed in the central channel of the needle should be one less than the number of components placed each in its own isolated volume. In this case, the partitions and holes on the side surface of the needle body should be located along the length of the needle so that in the working position of the needle within the boundaries of each of the isolated volumes was one of the partitions with openings located on opposite sides of it.

Краткое описание чертежейBrief Description of the Drawings

На фиг.l представлен общий вид заявляемой иглы; на фиг.2 представлен 5 общий вид шприца-тюбика, в котором используется заявляемая игла; на фиг.З представлен общий вид шприца с поршнем, в котором используется заявляемая игла.In Fig.l presents a General view of the inventive needle; figure 2 presents 5 General view of the syringe tube, which uses the inventive needle; Fig. 3 shows a general view of a syringe with a piston in which the inventive needle is used.

Лучший вариант осуществления изобретенияThe best embodiment of the invention

Игла (фиг.l) содержит корпус I 5 внутри которого по его продольной оси ю выполнен центральный канал 2, соединенный с расположенными на противоположных концах иглы входным и выходным отверстиями 3 и 4 иглы. В центральном канале 2 сформированы полностью перекрывающие его перегородкиThe needle (Fig. 1) contains a housing I 5 inside of which, along its longitudinal axis ω, a central channel 2 is made, connected to the inlet and outlet openings 3 and 4 of the needle located at opposite ends of the needle. In the central channel 2, completely overlapping partitions are formed

55 выполненные, например, с помощью лазерной сварки или путем механического обжатия корпуса 1 иглы. На боковой поверхности корпуса 1 иглы по одну сторону5 5 performed, for example, by laser welding or by mechanical crimping of the needle body 1. On the side surface of the needle body 1 on one side

15 каждой из перегородок 5 имеются отверстия 6, а по другую сторону - отверстия 7, сообщающиеся с центральным каналом 2.15 of each of the partitions 5 there are openings 6, and on the other side, openings 7 communicating with the central channel 2.

На фиг.2 представлен шприц-тюбик, содержащий деформируемый корпус, в верхней части которого установлена заявляемая игла 8. Корпус образован двумя изолированными друг от друга резервуарами 9 и 10, разделенными мембранами 11 и 20 12. Резервуары 9 и 10 соединены друг с другом, например, с помощью резьбового соединения, В верхнем резервуаре 9 находится порошкообразный компонент лекарственного средства, в нижнем резервуаре 10 находится жидкий компонент лекарственного препарата. Резервуар 9 имеет горловину 13, соединенную посредством резьбового соединения с насадкой 14, в которой закреплена игла 8. 25 Игла 8 вблизи входного отверстия 3 в центральном канале 2 содержит перегородку 5, по одну сторону от которой на боковой поверхности корпуса 1 иглы 8 имеются расположенные напротив друга отверстия 6, а по другую сторону - отверстия 7.Figure 2 shows a syringe tube containing a deformable body, in the upper part of which is installed the inventive needle 8. The body is formed by two isolated from each other tanks 9 and 10, separated by membranes 11 and 20 12. The tanks 9 and 10 are connected to each other, for example, using a threaded connection, In the upper reservoir 9 there is a powdered component of the drug, in the lower reservoir 10 is the liquid component of the drug. The tank 9 has a neck 13 connected by a threaded connection to the nozzle 14, in which the needle is fixed 8. 25 The needle 8 near the inlet 3 in the central channel 2 contains a partition 5, on one side of which on the side surface of the body 1 of the needle 8 there are opposite other holes 6, and on the other side - holes 7.

На фиг.З представлен шприц с поршнем, содержащий жесткий корпус 15, в верхней части которого установлена заявляемая игла 8 В полости корпуса по его зо высоте сверху вниз последовательно установлены изолированные друг от друга капсула 16 с первым порошкообразным компонентом лекарственного препарата, капсула 17 со вторым порошкообразным препаратом и капсула 18 с жидким компонентом. Корпус 15 шприца имеех горловину 13, на которой с помощью насадки 14 закреплена игла 8, содержащая две перегородки 5 в центральном каналеFig. 3 shows a syringe with a piston containing a rigid body 15, in the upper part of which the inventive needle 8 is installed. In the cavity of the body, capsule 16 with the first powder component of the drug, isolated from each other, capsule 17 with the second powdered preparation and capsule 18 with liquid component. The case 15 of the syringe has a neck 13, on which, with the help of the nozzle 14, a needle 8 is fixed, containing two partitions 5 in the central channel

2, по одну сторону каждой из которых на боковой поверхности иглы 8 расположены отверстия 6, а по другую сторону - отверстия 7. В нижней части корпуса 15 установлен с возможностью поступательного перемещения поршень 19, закрепленный на штоке 20, в котором выполнен канал 21, предназначенный для размещения в нем нижней части иглы 8.2, on one side of each of which holes 6 are located on the lateral surface of the needle 8, and holes 7 are located on the other side of the piston 19. The piston 19 is mounted with the possibility of translational movement and is mounted on the rod 20, in which the channel 21 is designed for placement in it of the lower part of the needle 8.

Работа заявляемой иглы в составе описанных выше инъекционных устройствах осуществляется следующим образом. В устройстве, представленном на фиг.2, заявляемая игла 8 в исходном положении устанавливается таким образом, что ее нижняя часть с перегородкой 5 и отверстиями 6 и 7 находится в границах верхнего резервуара 9, а ее входной конец, на котором расположено входное отверстие 3, размещается выше мембраны 11. Для приведения инъекционного устройства в рабочее положение с помощью резьбового соединения перемещают насадку 14 по горловине 13 вниз до тех пор, пока игла 8 не займет такое положение, при котором ее входной конец с отверстием 3 , проткнув мембраны 11 и 12, окажется в верхней части резервуара 10, а отверстия 6 будут по- прежнему находиться в пределах верхнего резервуара 9. Надавливают на деформируемый корпус шприца-тюбика, при этом жидкий компонент из нижнего резервуара 10 поступает в центральный канал 2 иглы 8 через ее входное отверстиеThe operation of the inventive needle in the composition of the injection devices described above is as follows. In the device shown in figure 2, the inventive needle 8 in the initial position is set so that its lower part with a partition 5 and holes 6 and 7 is located within the boundaries of the upper tank 9, and its inlet end, on which the inlet 3 is located, is placed above the membrane 11. To bring the injection device into working position, by means of a threaded connection, the nozzle 14 is moved down the neck 13 until the needle 8 occupies a position where its inlet end with hole 3 pierces the membrane 11 and 12, will be in the upper part of the reservoir 10, and the holes 6 will still be located within the upper reservoir 9. Press on the deformable body of the syringe tube, while the liquid component from the lower reservoir 10 enters the central channel 2 of the needle 8 through its inlet hole

3, а затем вытесняется через отверстия б, находящееся ниже перегородки 5, в верхний резервуар 9, где происходит его смешивание с находящимся в указанном резервуаре порошкообразным компонентом.. При дальнейшем сдавливании корпуса шприца-тюбика смесь компонентов поступает через отверстия 7 иглы 8, расположенные выше перегородки 5, в центральный канал 2 иглы 8, по которому транспортируется к выходному концу иглы 8, на котором расположено выходное отверстие 4.3, and then is displaced through holes b, located below the partition 5, into the upper tank 9, where it is mixed with the powder component located in the specified tank. With further squeezing of the syringe-tube case, the mixture of components enters through the holes 7 of the needle 8 located above partitions 5, into the central channel 2 of the needle 8, through which it is transported to the output end of the needle 8, on which the outlet 4 is located.

В устройстве, представленном на фиг.З, заявляемая игла 8 в исходном положении располагается таким образом, что ее нижняя часть проходит через капсулы 16 и 17, при этом входной конец wглът 8, на котором расположено входное отверстие 3, находится выше донной части капсулы 17, ближайшая к входному концу иглы 8 с отверстием 3 иглы 8 первая перегородка 5 и расположенные по разные стороны от нее отверстия б и 7 находятся в границах объема капсулы 17, а следующая вторая перегородка 5 и расположенные по разные стороны от нее отверстия 6 и 7 находятся в границах капсулы 16. При приложении внешнего давления к поршню 19 он начинает перемещаться к верхней части корпуса 15, при этом входной конец с отверстием 3 иглы 8 протыкает верхнюю часть оболочки капсулы 18 и нижнюю часть оболочки капсулы 17. При дальнейшем перемещении поршня 19 жидкий компонент из капсулы 18 поступает в центральный канал 2 иглы 8 через ее входное отверстие 3, вытесняется через отверстия б, находящееся ниже первой перегородки 5, в капсулу 17, где происходит его смешивание с находящимся в указанной капсуле первым порошкообразным компонентом. При дальнейшем перемещении поршня 19 образовавшаяся смесь компонентов из объема капсулы 17 поступает через отверстия 7, расположенные выше первой перегородки 5, в центральный канал 2 иглы 8 и из него вытесняется через отверстия 6, расположенные ниже второй перегородки 5, в объем капсулы 16. В объеме капсулы 16 к смеси первых двух компонентов примешивается второй порошкообразный компонент, и образовавшаяся трехкомпонентная смесь через отверстия 7, находящиеся выше второй перегородки 5, поступает в центральный канал 2 иглы 8 и далее транспортируется по нему к выходному концу иглы 8, на котором расположено выходное отверстие 4. По мере продвижения поршня 19 в корпусе 15 и опорожнения резервуаров 18, 17, 16 нижняя часть иглы 8 входит в канал 21 штока 20 и перемещается в нем.In the device shown in FIG. 3, the inventive needle 8 is in the initial position so that its lower part passes through the capsules 16 and 17, while the inlet end wglt 8, on which the inlet 3 is located, is located above the bottom of the capsule 17 closest to the inlet end of the needle 8 with the hole 3 of the needle 8 is the first partition 5 and located along different sides of the hole b and 7 are within the boundaries of the volume of the capsule 17, and the next second partition 5 and the holes 6 and 7 located on different sides of it are located within the boundaries of the capsule 16. When external pressure is applied to the piston 19, it begins to move to the upper part case 15, while the input end with the hole 3 of the needle 8 pierces the upper part of the capsule shell 18 and the lower part of the capsule shell 17. With further movement of the piston 19, the liquid component from the capsule 18 enters the central channel 2 of the needle 8 through its inlet 3, ytesnyaetsya through openings b located below the first partition wall 5, into the capsule 17, where it is mixing with the capsule located in said first pulverulent component. With further movement of the piston 19, the resulting mixture of components from the volume of the capsule 17 enters through the openings 7 located above the first septum 5 into the central channel 2 of the needle 8 and is displaced through the openings 6 located below the second septum 5 into the volume of the capsule 16. In the volume the capsule 16, a second powder component is mixed into the mixture of the first two components, and the resulting three-component mixture through the holes 7 located above the second partition 5, enters the central channel 2 of the needle 8 and then transport I thereon to the output end of the needle 8 which is arranged an outlet opening 4. As the advancement of the piston 19 in the housing 15 and discharge reservoirs 18, 17, 16, the lower portion of the needle 8 is included in the stem 20 and the channel 21 is moved therein.

Промышленная применимостьIndustrial applicability

Заявляемая игла может найти широкое применение в различных типах инъекционных устройств типа шприцов для инъекций смеси в виде раствора или суспензии двух и более компонентов лекарственного препарата. The inventive needle can be widely used in various types of injection devices such as syringes for injection of a mixture in the form of a solution or suspension of two or more components of a drug.

Claims

ФОРМУЛА ИЗОБРЕТЕНИЯ CLAIM Игла для инъекций, содержащая корпус (1), в котором выполнен центральный канал (2), соединенный с расположенными на противоположных концах иглы входным и выходным отверстиями (3,4), а также отверстия (6,7) на боковой поверхности корпуса, сообщающиеся с центральным каналом (2), отличающаяся тем, что в центральном канале (2) сформирована по меньшей мере одна полностью перекрывающая указанный канал перегородка (5), при этом по разные стороны от перегородки (5) на боковой поверхности корпуса (1) расположено по меньшей мере по одному отверстию (6,7). An injection needle comprising a body (1) in which a central channel (2) is made connected to inlet and outlet openings (3.4) located at opposite ends of the needle, as well as openings (6.7) on the side surface of the body, communicating with a central channel (2), characterized in that at least one partition (5) is completely formed in the central channel (2), while on different sides of the partition (5) on the side surface of the housing (1) is located at least one hole (6.7).
PCT/RU2006/000325 2006-06-14 2006-06-14 Injection cannula Ceased WO2007149005A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2006/000325 WO2007149005A1 (en) 2006-06-14 2006-06-14 Injection cannula

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2006/000325 WO2007149005A1 (en) 2006-06-14 2006-06-14 Injection cannula

Publications (1)

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WO2007149005A1 true WO2007149005A1 (en) 2007-12-27

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PCT/RU2006/000325 Ceased WO2007149005A1 (en) 2006-06-14 2006-06-14 Injection cannula

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653607A (en) * 1950-09-16 1953-09-29 Ayerst Mckenna & Harrison Injection apparatus
US3911916A (en) * 1971-10-29 1975-10-14 Peter A Stevens Sequential injection syringe
RU2238763C1 (en) * 2003-01-20 2004-10-27 Сухонос Юрий Анатольевич Device for injecting drugs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653607A (en) * 1950-09-16 1953-09-29 Ayerst Mckenna & Harrison Injection apparatus
US3911916A (en) * 1971-10-29 1975-10-14 Peter A Stevens Sequential injection syringe
RU2238763C1 (en) * 2003-01-20 2004-10-27 Сухонос Юрий Анатольевич Device for injecting drugs

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