[go: up one dir, main page]

WO2007039318A3 - Neuropeptide y analogs - Google Patents

Neuropeptide y analogs Download PDF

Info

Publication number
WO2007039318A3
WO2007039318A3 PCT/EP2006/009812 EP2006009812W WO2007039318A3 WO 2007039318 A3 WO2007039318 A3 WO 2007039318A3 EP 2006009812 W EP2006009812 W EP 2006009812W WO 2007039318 A3 WO2007039318 A3 WO 2007039318A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
npy
analogs
peptide
affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/009812
Other languages
French (fr)
Other versions
WO2007039318A2 (en
Inventor
Ananth Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of WO2007039318A2 publication Critical patent/WO2007039318A2/en
Publication of WO2007039318A3 publication Critical patent/WO2007039318A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57545—Neuropeptide Y

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The neuropeptideY (NPY) -receptor-subtype Yl is expressed differentially from breast tumor cells and is therefore an advantageous target molecule for the molecular imaging of breast cancer. Peptide analogs were synthesized, whose sequence is reduced to the receptor-binding sections of the natural ligand NPY. These Yl receptor-selective peptide analogs contain unnatural amino acids that increase the receptor affinity and are to ensure the stability of the greatly shortened peptide. New NPY analogs, which are to be used as radioligands, were tested for their binding affinity and selectivity for the Yl receptor.
PCT/EP2006/009812 2005-10-06 2006-10-05 Neuropeptide y analogs Ceased WO2007039318A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72390905P 2005-10-06 2005-10-06
US60/723,909 2005-10-06

Publications (2)

Publication Number Publication Date
WO2007039318A2 WO2007039318A2 (en) 2007-04-12
WO2007039318A3 true WO2007039318A3 (en) 2007-07-05

Family

ID=37742520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/009812 Ceased WO2007039318A2 (en) 2005-10-06 2006-10-05 Neuropeptide y analogs

Country Status (1)

Country Link
WO (1) WO2007039318A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA102888C2 (en) 2009-02-20 2013-08-27 Іпсен Фарма С.А.С. Analogues of neuropeptide y having proline substitution at position 34
EP2398485A4 (en) 2009-02-20 2013-01-09 Ipsen Pharma Sas Analogues of neuropeptide y having at least one synthetic amino acid substitution
CN102325545A (en) * 2009-02-20 2012-01-18 益普生制药股份有限公司 Peptide-cytotoxic conjugates with neuropeptide Y receptor binding compounds
EP2708243A1 (en) * 2012-09-17 2014-03-19 OntoChem GmbH Receptor ligand linked cytotoxic molecules

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311756A1 (en) * 1993-04-08 1994-10-13 Thomae Gmbh Dr K Modified peptides, pharmaceutical compositions containing these compounds, and processes for their production
WO2002043776A2 (en) * 2000-11-24 2002-06-06 Reubi Jean Claude Neuropeptide y1 receptor binding compounds in the treatment and diagnosis of cancer
WO2003026591A2 (en) * 2001-09-24 2003-04-03 Imperial College Innovations Ltd. Modification of feeding behavior
WO2004009628A1 (en) * 2002-07-23 2004-01-29 Bioacta Limited Inhibition of cell division based use of analogs of neuropeptide y

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311756A1 (en) * 1993-04-08 1994-10-13 Thomae Gmbh Dr K Modified peptides, pharmaceutical compositions containing these compounds, and processes for their production
WO2002043776A2 (en) * 2000-11-24 2002-06-06 Reubi Jean Claude Neuropeptide y1 receptor binding compounds in the treatment and diagnosis of cancer
WO2003026591A2 (en) * 2001-09-24 2003-04-03 Imperial College Innovations Ltd. Modification of feeding behavior
WO2004009628A1 (en) * 2002-07-23 2004-01-29 Bioacta Limited Inhibition of cell division based use of analogs of neuropeptide y

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DECKERT CM ET AL.: "Characterisation of Breast Cancer Cells for Neuropeptide Y Binding Sites", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 32, no. 4, August 2004 (2004-08-01), pages 81A, XP008077683, ISSN: 0300-5127 *
KOGLIN N ET AL.: "Analogues of Neuropeptide Y Containing .beta.-Aminocyclopropane Carboxylic Acids are the Shortest Linear Peptides That Are Selective for the Y1 Receptor", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 42, no. 2, 2003, pages 202 - 205, XP002428864, ISSN: 1433-7851 *
LEBAN JJ ET AL.: "Novel Modified Carboxy Terminal Fragments of Neuropeptide Y with High Affinity for Y2-Type Receptors and Potent Functional Antagonism at a Y1-Type Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 7, 1995, pages 1150 - 1157, XP002428863, ISSN: 0022-2623 *
MICHEL MC ET AL.: "Further Characterization of Neuropeptide Y Receptor Subtypes using Centrally Truncated Analogs of Neuropeptide Y: Evidence for Subtype-Differentiating Effects on Affinity and Intrinsic Efficacy", MOLECULAR PHARMACOLOGY, vol. 42, no. 4, 1992, pages 642 - 648, XP008077687 *
PROSKE D ET AL.: "A Y2 Receptor Mimetic Aptamer Directed against Neuropeptide Y", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 13, 29 March 2002 (2002-03-29), pages 11416 - 11422, XP002428865 *
REUBI J C ET AL: "Y1-MEDIATED EFFECT OF NEUROPEPTIDE Y IN CANCER: BREAST CARCINOMAS AS TARGETS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, no. 11, 1 June 2001 (2001-06-01), pages 4636 - 4641, XP001156605, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2007039318A2 (en) 2007-04-12

Similar Documents

Publication Publication Date Title
JP7417432B2 (en) New linker, its production method and its application
WO2009068625A3 (en) Amino acid sequences directed against her2 and polypeptides comprising the same for the treatment of cancers and/or tumors
NO20082559L (en) Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies
ES2882634T3 (en) Peptide compounds and peptide conjugates for the treatment of cancer by receptor-mediated chemotherapy
WO2013036778A3 (en) Compstatin analogs with improved pharmacokinetic properties
TN2009000194A1 (en) Novel antiproliferation antibodies
WO2006105021A3 (en) Gitr binding molecules and uses therefor
WO2008074004A3 (en) Human antibodies that bind cd70 and uses thereof
WO2011133886A3 (en) Production of heteromultimeric proteins
WO2009073546A3 (en) Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7)
MY162624A (en) Antibodies directed to her-3 and uses thereof
EA200800696A1 (en) POLYPEPTIDES AND ANTIBODIES
WO2006089230A3 (en) Human monoclonal antibodies to prostate specific membrane antigen (psma)
Chua et al. Small cyclic agonists of iron regulatory hormone hepcidin
UA97516C2 (en) Fully human anti-vap-1 monoclonal antibody
HRP20240495T1 (en) ANTI-GARP ANTIBODY
WO2007094842A3 (en) Binding polypeptides and uses thereof
EP3009454A3 (en) Antibodies specific to cadherin-17
PH12020500137A1 (en) Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods
MX2009012358A (en) Optical imaging agents.
WO2006017619A3 (en) Receptor-binding cyclic peptides and methods of use
WO2009061130A3 (en) Cell permeable runx3 recombinant proteins, polynucleotides encoding the same, and anticancer compositions including the same
JO2991B1 (en) IL-17 Receptor A antigen binding proteins
WO2006034278A3 (en) Methods and compositions for detecting cancer using components of the u2 spliceosomal particle
JP2018507689A5 (en)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06818254

Country of ref document: EP

Kind code of ref document: A2