WO2007031620B1 - Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation - Google Patents
Mousses dermatologiques a base de metronidazole et emulsions pour leur preparationInfo
- Publication number
- WO2007031620B1 WO2007031620B1 PCT/FR2006/002037 FR2006002037W WO2007031620B1 WO 2007031620 B1 WO2007031620 B1 WO 2007031620B1 FR 2006002037 W FR2006002037 W FR 2006002037W WO 2007031620 B1 WO2007031620 B1 WO 2007031620B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mass
- metronidazole
- emulsions
- preparation
- production
- Prior art date
Links
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 title claims abstract 6
- 229960000282 metronidazole Drugs 0.000 title claims abstract 6
- 239000000839 emulsion Substances 0.000 title claims abstract 5
- 239000006260 foam Substances 0.000 title claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 5
- 229940124532 absorption promoter Drugs 0.000 claims abstract 2
- 239000003349 gelling agent Substances 0.000 claims abstract 2
- 239000002480 mineral oil Substances 0.000 claims abstract 2
- 235000010446 mineral oil Nutrition 0.000 claims abstract 2
- 239000003755 preservative agent Substances 0.000 claims abstract 2
- 239000004094 surface-active agent Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims 3
- 241001303601 Rosacea Species 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des émulsions comprenant, en pourcentage en masse par rapport à la masse totale de Ia composition : (a) 70% a 81 % d'eau ; (b) 0,1% a 5% d'un agent gélifiant de la phase aqueuse de l'émulsion ; (c) 0,75% a 2% de métronidazole ; (d) 4% a 10% d'huile minérale ; (e) 0,5% a 10% d'un agent tensioactif ; (f) 0,5% a 5% d'un acide gras ; (g) 0,1% a 5% d'un agent conservateur ; et (h) 0 a 5% d'un promoteur d'absorption du métronidazole. L'invention concerne également des mousses à base de métronidazole obtenues à partir de ces émulsions, ainsi que leur utilisation dermatologique.
Claims
1. Composition à base de métronidazole choisie parmi les compositions suivantes :
2. Procédé de préparation d'une composition selon la revendication 1 , comprenant les étapes successives suivantes : - on prépare un milieu aqueux A comprenant l'eau (a), l'agent gélifiant (b), le métronidazole (c), le tensioactif (e), et, le cas échéant, le promoteur d'absorption (h) ;
- on prépare un milieu hydrophobe H comprenant l'huile minérale (d), et tout autre constituant de la phase grasse ; - on mélange les milieux A et H ainsi obtenus, et on émulsifie le système ainsi formé ;
- le conservateur (g) est ajouté en fin d'émulsification ;
- mélange de l'émulsion obtenue avec un gaz.
3. Utilisation d'une composition selon la revendication 1 , pour la préparation d'une mousse dermatologique destinée au traitement prophylactique ou thérapeutique d'une affection cutanée, par voie topique. 44
4. Utilisation selon la revendication 3, pour la préparation d'une mousse dermatologique destinée au traitement de la rosacée.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06808065A EP1928416A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
| US12/076,115 US20090041678A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
| US13/154,476 US20110237637A1 (en) | 2005-09-13 | 2011-06-07 | Metronidazole-based dermatological foam and emulsions for the production thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0509342A FR2890560B1 (fr) | 2005-09-13 | 2005-09-13 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
| FR0509342 | 2005-09-13 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US12/076,115 Continuation US20090041678A1 (en) | 2005-09-13 | 2008-03-13 | Metronidazole-based dermatological foams and emulsions for the preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2007031620A2 WO2007031620A2 (fr) | 2007-03-22 |
| WO2007031620A3 WO2007031620A3 (fr) | 2007-05-03 |
| WO2007031620B1 true WO2007031620B1 (fr) | 2007-06-21 |
Family
ID=36601229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FR2006/002037 WO2007031620A2 (fr) | 2005-09-13 | 2006-09-05 | Mousses dermatologiques a base de metronidazole et emulsions pour leur preparation |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20090041678A1 (fr) |
| EP (1) | EP1928416A2 (fr) |
| FR (1) | FR2890560B1 (fr) |
| WO (1) | WO2007031620A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2725904B1 (fr) | 2011-06-28 | 2024-12-11 | Chemo Research SL | Formulations de gel à base de métronidazole aqueux mucoadhésif à dosage élevé et leur utilisation pour traiter une vaginose bactérienne |
| WO2018213609A1 (fr) | 2017-05-17 | 2018-11-22 | Ausubel Frederick M | Composés antibiotiques |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| US5536743A (en) * | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| US5300491A (en) * | 1991-10-31 | 1994-04-05 | Apothekernes Laboratorium A.S. | Treatment of protozoal infection |
| US6468989B1 (en) * | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| CA2502986C (fr) * | 2002-10-25 | 2011-08-23 | Foamix Ltd. | Mousse cosmetique et pharmaceutique |
| EP1663148A2 (fr) * | 2003-08-25 | 2006-06-07 | Foamix Ltd. | Mousse pharmaceutique de penetration |
| WO2005115336A2 (fr) * | 2004-05-15 | 2005-12-08 | Collegium Pharmaceutical, Inc. | Formulations pulverisables destinees au traitement d'etats dermiques inflammatoires aigus |
| US20060024243A1 (en) * | 2004-08-02 | 2006-02-02 | Agis Industries (1983) Ltd. | Foamable compositions containing nitro-imidazoles, processes for preparing same and methods of treatment utilizing same |
-
2005
- 2005-09-13 FR FR0509342A patent/FR2890560B1/fr not_active Expired - Fee Related
-
2006
- 2006-09-05 WO PCT/FR2006/002037 patent/WO2007031620A2/fr active Application Filing
- 2006-09-05 EP EP06808065A patent/EP1928416A2/fr not_active Withdrawn
-
2008
- 2008-03-13 US US12/076,115 patent/US20090041678A1/en not_active Abandoned
-
2011
- 2011-06-07 US US13/154,476 patent/US20110237637A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110237637A1 (en) | 2011-09-29 |
| FR2890560B1 (fr) | 2011-06-24 |
| EP1928416A2 (fr) | 2008-06-11 |
| WO2007031620A2 (fr) | 2007-03-22 |
| US20090041678A1 (en) | 2009-02-12 |
| FR2890560A1 (fr) | 2007-03-16 |
| WO2007031620A3 (fr) | 2007-05-03 |
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