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WO2007029121A3 - Novel cyclopent-2-en-1-one derivatives which are ppar receptor modulators, and use thereof in pharmaceutical or cosmetic compositions - Google Patents

Novel cyclopent-2-en-1-one derivatives which are ppar receptor modulators, and use thereof in pharmaceutical or cosmetic compositions Download PDF

Info

Publication number
WO2007029121A3
WO2007029121A3 PCT/IB2006/003436 IB2006003436W WO2007029121A3 WO 2007029121 A3 WO2007029121 A3 WO 2007029121A3 IB 2006003436 W IB2006003436 W IB 2006003436W WO 2007029121 A3 WO2007029121 A3 WO 2007029121A3
Authority
WO
WIPO (PCT)
Prior art keywords
cosmetic compositions
pharmaceutical
novel
cyclopent
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2006/003436
Other languages
French (fr)
Other versions
WO2007029121A2 (en
Inventor
Lera Angel Rodriguez De
Cabredo Maria Paz Otero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Galderma Research and Development SNC
Original Assignee
Galderma Research and Development SNC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0507769A external-priority patent/FR2888846B1/en
Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC
Publication of WO2007029121A2 publication Critical patent/WO2007029121A2/en
Publication of WO2007029121A3 publication Critical patent/WO2007029121A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/80—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings
    • C07C59/82—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings the keto group being part of a ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to novel compounds which correspond to general formula (I) below: and also to the method for preparing them, and to their use in pharmaceutical compositions for use in human or veterinary medicine, in particular in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or diseases related to lipid metabolism, or alternatively in cosmetic compositions.
PCT/IB2006/003436 2005-07-21 2006-07-20 Novel cyclopent-2-en-1-one derivatives which are ppar receptor modulators, and use thereof in pharmaceutical or cosmetic compositions Ceased WO2007029121A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0507769A FR2888846B1 (en) 2005-07-21 2005-07-21 NOVEL CYCLOPENT-2-IN-1-ONE DERIVATIVES, MODULATORS OF PPAR RECEPTORS AND THEIR USE IN PHARMACEUTICAL OR COSMETIC COMPOSITIONS
FR0507769 2005-07-21
US70387405P 2005-08-01 2005-08-01
US60/703,874 2005-08-01

Publications (2)

Publication Number Publication Date
WO2007029121A2 WO2007029121A2 (en) 2007-03-15
WO2007029121A3 true WO2007029121A3 (en) 2007-06-21

Family

ID=37806109

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/003436 Ceased WO2007029121A2 (en) 2005-07-21 2006-07-20 Novel cyclopent-2-en-1-one derivatives which are ppar receptor modulators, and use thereof in pharmaceutical or cosmetic compositions

Country Status (1)

Country Link
WO (1) WO2007029121A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9206182B2 (en) 2009-07-15 2015-12-08 Intellikine Llc Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof
US9290497B2 (en) 2011-01-10 2016-03-22 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9527847B2 (en) 2012-06-25 2016-12-27 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX358640B (en) 2008-01-04 2018-08-29 Intellikine Llc Certain chemical entities, compositions and methods.
WO2010141932A1 (en) 2009-06-05 2010-12-09 Link Medicine Corporation Aminopyrrolidinone derivatives and uses thereof
CN105102000B (en) 2012-11-01 2021-10-22 无限药品公司 Cancer therapy using PI3 kinase isoform modulators
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659728A1 (en) * 1992-09-10 1995-06-28 Teijin Limited 4-hydroxy-2-cyclopentenone derivative and carcinostatic and osteogenesis promoter containing the same
US5981586A (en) * 1997-05-23 1999-11-09 Pershadsingh; Harrihar A. Methods for treating proliferative and inflammatory skin diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0659728A1 (en) * 1992-09-10 1995-06-28 Teijin Limited 4-hydroxy-2-cyclopentenone derivative and carcinostatic and osteogenesis promoter containing the same
US5981586A (en) * 1997-05-23 1999-11-09 Pershadsingh; Harrihar A. Methods for treating proliferative and inflammatory skin diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FORMAN B M ET AL: "15-DEOXY-DELTA 12,14-PROSTAGLANDIN J2 IS A LIGAND FOR THE ADIPOXYTE DETERMINATION FACTOR PPARY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 83, 1 December 1995 (1995-12-01), pages 803 - 812, XP000575803, ISSN: 0092-8674 *
NOYORI R.: "RATIONAL DESIGN OF ANTITUMOR PROSTAGLANDINS WITH HIGH BIOLOGICAL STABILITY", J. MED. CHEM., no. 41, 1998, pages 3084 - 3090, XP002385416 *
STRAUS D S ET AL: "CYCLOPENTENONE PROSTAGLANDINS: NEW INSIGHTS ON BIOLOGICAL ACTIVITIES AND CELLULAR TARGETS", MEDICINAL RESEARCH REVIEWS, NEW YORK, NY, US, vol. 21, no. 3, May 2001 (2001-05-01), pages 185 - 210, XP009035137, ISSN: 0198-6325 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216982B2 (en) 2008-01-04 2015-12-22 Intellikine Llc Certain chemical entities, compositions and methods
US9206182B2 (en) 2009-07-15 2015-12-08 Intellikine Llc Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof
US9522146B2 (en) 2009-07-15 2016-12-20 Intellikine Llc Substituted Isoquinolin-1(2H)-one compounds, compositions, and methods thereof
US9290497B2 (en) 2011-01-10 2016-03-22 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9527847B2 (en) 2012-06-25 2016-12-27 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors

Also Published As

Publication number Publication date
WO2007029121A2 (en) 2007-03-15

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