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WO2007013094A3 - Procede de preparation d'un compose antiandrogene - Google Patents

Procede de preparation d'un compose antiandrogene Download PDF

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Publication number
WO2007013094A3
WO2007013094A3 PCT/IN2006/000131 IN2006000131W WO2007013094A3 WO 2007013094 A3 WO2007013094 A3 WO 2007013094A3 IN 2006000131 W IN2006000131 W IN 2006000131W WO 2007013094 A3 WO2007013094 A3 WO 2007013094A3
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
preparation
trifluoromethyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2006/000131
Other languages
English (en)
Other versions
WO2007013094A2 (fr
Inventor
Umangkumar Natubhai Patel
Kamleshkumar Naran Borkhataria
Kanaksinh Jesingbhai Jadav
Trinadha Rao Chitturi
Rajamannar Thennati
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Ltd
Original Assignee
Sun Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd filed Critical Sun Pharmaceutical Industries Ltd
Publication of WO2007013094A2 publication Critical patent/WO2007013094A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007013094A3 publication Critical patent/WO2007013094A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation d'un composé antiandrogène, N-[4-cyano-3-(trifluorométhyl)phényl]-3-[(4-fluorophényl)sulfonyl]-2-hydroxy-2-méthylpropanamide, un composé de formule 1. Ce procédé consiste à faire réagir du N-[4-cyano-3-(trifluorométhyl)phényl]-2-méthyloxirane-2-carboxamide, un composé de formule 2, avec du 4-fluorothiophénol, un composé de formule 3, en présence d'un catalyseur de transfert de phase ; et à oxyder le N-[4-cyano-3-(trifluorométhyl)phényl]-3-[(4-fluorophényl)thio]-2-hydroxy-2-méthylpropanamide obtenu, un composé de formule 4, avec un réactif permanganate.
PCT/IN2006/000131 2005-04-15 2006-04-13 Procede de preparation d'un compose antiandrogene Ceased WO2007013094A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN465MU2005 2005-04-15
IN465/MUM/2005 2005-04-15

Publications (2)

Publication Number Publication Date
WO2007013094A2 WO2007013094A2 (fr) 2007-02-01
WO2007013094A3 true WO2007013094A3 (fr) 2007-11-01

Family

ID=37683747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000131 Ceased WO2007013094A2 (fr) 2005-04-15 2006-04-13 Procede de preparation d'un compose antiandrogene

Country Status (1)

Country Link
WO (1) WO2007013094A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000608A1 (fr) * 1999-06-10 2001-01-04 Richter Gedeon Vegyészeti Gyár Rt. Procede de synthese de n-(4-cyano-3-trifluoromethylephenyle)-3-(4-fluorophenyle-sulfonyle)-2-hydroxy-2-methylepropionamide
CN1458146A (zh) * 2002-05-15 2003-11-26 中国科学院上海药物研究所 抗肿瘤药物比卡鲁胺合成工艺
WO2004039769A1 (fr) * 2002-10-30 2004-05-13 Instytut Farmaceutyczny Procede pour la production de n-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylthio)-2-hydroxy-2-mthylpropanamide hautement pur

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000608A1 (fr) * 1999-06-10 2001-01-04 Richter Gedeon Vegyészeti Gyár Rt. Procede de synthese de n-(4-cyano-3-trifluoromethylephenyle)-3-(4-fluorophenyle-sulfonyle)-2-hydroxy-2-methylepropionamide
CN1458146A (zh) * 2002-05-15 2003-11-26 中国科学院上海药物研究所 抗肿瘤药物比卡鲁胺合成工艺
WO2004039769A1 (fr) * 2002-10-30 2004-05-13 Instytut Farmaceutyczny Procede pour la production de n-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylthio)-2-hydroxy-2-mthylpropanamide hautement pur

Also Published As

Publication number Publication date
WO2007013094A2 (fr) 2007-02-01

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